Abstracts 209 KININ AND RENAL FUNCTION. F. Alzamora (Belo Horizonte, MG, Brazil). When bradykinin is infused into the renal artery of dogs it decreases the proximal reabsorption of sodium and water and the secretion of p. aminohip- puric acid. It does not alter the capacity of the distal part of the nephron to lower the intratubular concen- tration of sodium (Alzamora & Capelo, 1973). The kidney under adequate stimulus is able to produce great amounts of kinin. A partial occlusion of the renal vein increases around twenty times the oxytocic acitivity of urine, the substance responsible for this increased activity being a kinin. It relaxes the rat duo- denum and contracts the rat uterus, the rat ileum and the guinea-pig ileum. It produces hypotension in rats and the activity is destroyed by chymotrypsin. It has been shown by several investigators that an expansion of the extracellular volume by saline infu- sion decreases sodium and water reabsorption in the proximal tubule. It is possible that the kinin system is involved in this compensatory renal response. ALZAMORA F. & CAPELOL. R, (1973) Agents Actions 3, 366.

Kinin and renal function

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Abstracts 209

KININ AND RENAL FUNCTION. F. Alzamora (Belo Horizonte, MG, Brazil).

When bradykinin is infused into the renal artery of dogs it decreases the proximal reabsorption of sodium and water and the secretion of p. aminohip- puric acid. It does not alter the capacity of the distal part of the nephron to lower the intratubular concen- tration of sodium (Alzamora & Capelo, 1973). The kidney under adequate stimulus is able to produce great amounts of kinin. A partial occlusion of the renal vein increases around twenty times the oxytocic acitivity of urine, the substance responsible for this increased activity being a kinin. It relaxes the rat duo-

denum and contracts the rat uterus, the rat ileum and the guinea-pig ileum. It produces hypotension in rats and the activity is destroyed by chymotrypsin. It has been shown by several investigators that an expansion of the extracellular volume by saline infu- sion decreases sodium and water reabsorption in the proximal tubule. It is possible that the kinin system is involved in this compensatory renal response.

ALZAMORA F. & CAPELO L. R, (1973) Agents Actions 3, 366.