KAFAIT U. MALIK, D.Sc., Ph.D.academic.uthsc.edu/docs/fac_port_cv/KUMalik_CV_R2015.pdfKAFAIT U. MALIK, D.Sc., Ph.D. 1 CURRICULUM VITAE Mailing Address: Department of Pharmacology The

KAFAIT U. MALIK, D.Sc., Ph.D.

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CURRICULUM VITAE

Mailing Address: Department of Pharmacology The University of Tennessee Health Science Center 874 Union Avenue Suite 215 Crowe, Building Memphis, TN 38163

Phone Number: 901-448-6075

Fax Number: 901-448-7206

E-mail: [email protected]

Date/Place of Birth: Sialkot, Pakistan

Citizenship: U.S.A.

Undergraduate: 1961 B. Pharm. Degree, University of Punjab, Lahore, Pakistan Graduate/Medical School:

1964 D.Sc., Pharmaceutical Technology, University of Zagreb, Zagreb, Yugoslavia 1966 M.Sc. and Ph.D. Pharmacology, University of Sarajevo, Sarajevo, Yugoslavia

1964-1966 Research Assistant, Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Yugoslavia

1966-1967 Research Associate, Institute of Pharmacology, Faculty of Medicine, University of Mainz, West Germany

1967-1969 Instructor, Department of Pharmacology, Faculty of Medicine, University of Ottawa, Ottawa, Canada

1970-1971 Instructor, Departments of Pharmacology and Internal Medicine, St. Louis University School of Medicine, St. Louis, Missouri

1971-1974 Assistant Professor, Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, Wisconsin

1974-1975 Associate Professor, Department of Pharmacology, Section of Clinical Pharmacology, The Medical College of Wisconsin, Milwaukee, Wisconsin

1975-1979 Associate Professor, Department of Pharmacology, University of Tennessee Center for the Health Sciences, Memphis, Tennessee

1979 – Present Professor, Department of Pharmacology, University of Tennessee Center for the Health

University Appointments:

Education and Training:

mailto:[email protected]


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Sciences, Memphis, Tennessee 1988-1995 Vice Chairman, Department of Pharmacology, University of Tennessee Center for the

Health Sciences, Memphis, Tennessee 2008-2011 Vice Chairman, Department of Pharmacology, University of Tennessee Center for the

Health Sciences, Memphis, Tennessee 2003-2008 Director, NIH Training Program “Lipid/Lipoprotein Metabolism and Cardiovascular

Diseases”

po Autonomic Physiology and Pharmacology

Vascular Smooth Muscle Physiology and Pharmacology Cardiovascular and Renal Physiology and Pharmacology

ntments: Adrenergic Nervous System Physiology and Pharmacology Cardiovascular Actions of Prostaglandins, Angiotensins and Kinins, sex hormones Neurohormonal Interactions (Prostaglandins, Renin-angiotensin, growth factors and adrenergic nervous system),

Vascular smooth muscle and Neural control of heart, vascular and renal function Neuro-humoral mechanisms involved in the development of Hypertension, Vascular Injury and restenosis and Atherosclerosis and role of sex hormones

a) Cellular and Molecular Mechanisms of Coupling of Adrenergic Transmitter with Various Lipases through its

Interaction with Different Adrenergic Receptors via G Proteins and Ras/Raf/MAP Kinase, Ca2+/Calmodulin-dependent Kinases, and other signaling molecules.

b) Cellular and Molecular Mechanisms of action of Neurohumoral Factors (Norepinephrine, Angiotensin II ,

Arachidonic Acid Metabolites, sex hormones and growth factors) on Vascular Smooth Muscle Cell Migration, Hypertrophy and Hyperplasia and Hypertension, atherosclerosis and restenosis.

Fellow of the Commission for Cultural Relations with Foreign Countries, Government of Yugoslavia, 1961-65 Fellow of Ontario Mental Health Foundation, Canada, 1968-70 USPHS Research Career Development Awardee, 1975-80 Teaching Excellence Award in Basic Sciences (Outstanding Teacher), 1985, 1988, 1990 Merit Awardee of National Heart, Lung and Blood Institute, 1987-1997 Golden Apple Award for Excellence in Teaching Pharmacology, 1992 (College of Medicine) Student Government Association Executive Council (SGAEC) Excellence in Teaching Award, Graduate School of

Honors and Awards:

Principal Areas of Current Research:

Principal Areas of Expertise:

Areas of Special Training:


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CURRICULUM VITAE

Health Sciences, 1993(College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 1993 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 1994 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 1995 (College of Medicine) Recognition of Enthusiasm and Support Award, 1995 (M2 Class of 1997) (College of Medicine) SGAEC Excellence in Teaching Award in Basic Sciences, 1995 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 1996 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 1998 (College of Medicine) Sigma Xi Award for Excellence in Research, 1998 Golden Apple Award for Excellence in Teaching Pharmacology, 1999 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 2000 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 2001 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 2002 (College of Medicine) Golden Apple Award for Excellence in Teaching Pharmacology, 2004 (College of Medicine)

Honors

International Society for Biochemical Pharmacology – 1965-1980 Yugoslav Pharmacological and Physiological Society – 1965-1975 American Federation for Clinical Research – 1973-1980 German Pharmacological Society – 1967-Present Canadian Pharmacological Society – 1968-Present American Society for Pharmacology and Experimental Therapeutics – 1970-Present High Blood Pressure Council - American Heart Association – 1972-Present American Physiological Society – 1974-Present British Pharmacological Society – 1975-Present American Society for Biochemistry and Molecular Biology- 2007-Present

A. Professional Courses (Teaching and occasionally organization) 1. Graduate Medical Pharmacology (1967-Present) Pharmacy Pharmacology (1975-1987) Dental Pharmacology (1980-2009) Nursing Pharmacology (1975-2005) Advanced Courses for Pharmacology. Graduates (Neuropharmacology) (1975-2005) Cellular Neuroscience (1994-2007) Masters Pharmacology (2009- 2013) Graduate course in signaling (2015-present)

Educational Experience:

Society Memberships:


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2. Post-graduate Neurology Residents (1975-2000) Nursing (1975- 2005) Pediatric Dentistry and Periodontics (1985- 2006)

B. Training of Graduate Students and Postdoctoral Fellows 1. Graduate Students Name Years of Training Current Position S.M. Lanier 1979-1982 Professor and Provost for Research Medical University of South Carolina, Charleston, S.C. C.L. Cooper 1982-1985 CEO and President, Inspire Pharmaceuticals, Research

Triangle, NC W. Oellerich, M.D. 1986-1992 Fellow, Division of Cardiology, Dept. of Medicine, Washington

University, St. Louis, Missouri C. Nebigil 1988-1992 Staff Scientist, CNRS, INSERM, ULP, Strasburg, France H. Kan 1992-1996 Asociate Professor, Dept. of Medicine, Section of Cardiol.,

West Virginia University Health Sciences Center, Morgantown, WV

H. Wright 1992-1996 Principal Scientist, Pharmacology, Forest Research Institute, A

Division of Forest Labs, Inc. Jersey City, NJ S. Kalyankrishna 1998-2002 Postdoctoral Fellow, Dept. of Pharmacology, University of

Pittsburgh, Pittusburgh, PA F. Li 2000 - 2005 Postdoctoral Fellow, Dept. of Medicine, School of Medicine,

University of California, LA, CA N. Khan 2009- 2014 University of Tennessee HSC, Memphis, Postdoctoral Fellow at Feinstein Research Institute, N.Y.

2. Postdoctoral Fellows

M.T. Khan, Ph.D. 6/1/77-9/23/78 Assoc. Prof., Down State Med. Sch., New York, NY T. Hidaka, M.D., Ph.D. 1/1/78-8/31/80 Assoc. Prof., Kurume University, Kurume, Japan -Now Private

Practice E. Duzic, D.V.M. 1/1/79-10/31/79 Associate Director, Cell Biology Millenium, Pharmaceuticals,

Inc. Cambridge, MA (Retired) H. Susic, M.D., Ph.D. 1/1/79-8/31/80 Chrm., Dept. of Pathphys., Univ. of Tuzla, Bosnia, and

Hercogovia (Deceased) S. Chiba, M.D., Ph.D. 5/1/79-7/1/80 Chrm., Dept. of Pharm., Shinshu University, Matsumato, Japan (Retired) T. Homa, M.D. 8/1/80-8/31/81 Chrm., Div. of Cardiology, Dept. of Medicine, Shinshu Univ.,

Matsumato, Japan (Retired) J.E. Shaffer, Ph.D. 1/1/80-6/31/82 Chief of Pharmacology, Galaxo Pharmaceuticals, Research

Triangle, NC (Retired) K. Inokuchi, M.D., Ph.D. 1/8/80-12/31/82 Prof. of Pharmacology, Hirosaki University, Hokaido, Japan

(Retired) T. Böke, M.D. 10/1/80-6/31/83 Assoc. Prof, VA Hosp., Tampa, FL


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K. Iwatsuki, M.D., Ph.D. 8/20/83-8/31/84 Prof., Shinshu University, Matsumato, Japan (Retired) M. Weis, M.D. 6/1/83-6/30/86 Prof., Coll. of Pharmacy, Univ. of Texas, Amarillo, Texas T. Kuroda, M.D. 5/15/84-4/15/86 Prof. of Surgery, Shinshu University, Matsumato, Japan (Retired to Private Practice) M.M. Mohy El-Din, Ph.D. 9/1/85-8/31/87 Prof. of Pharm., Univ. of Beruit, Lebanon N. Jaiswal, Ph.D. 10/1/85-9/30/87 Staff Scientist-Current address not known. L. Williams, Ph.D., M.D. 3/1/85-3/31/88 Physician –Private Practice (current address not known) Z. Qureshi, Ph.D. 9/1/85-8/31/90 Prof., Rust College, Holly Springs, Mississippi

A. Adeagbo, Ph.D. 9/15/87-1/31/89 Prof., Dept. of Physiology, University of Louisville, Louisville, KY- Moved to New York, Current address not known

C. Cano, Ph.D. 9/1/88-2/28/92 Prof. of Biochem., Univ. of Maracaibo, Maracaibo, Venezuela (Retired)

E. Sehic, M.D. 12/1/87-6/31/92 Physician (Private Practice) (current address not known) D. Schwartz, Ph.D. 9/1/87-8/31/91 Prof., Dept. of Physiology & Pharmacol., Auburn University,

Auburn, Alabama K. Slavik, Ph.D. 3/1/92-6/30/93 Biotech Company (address not known) G. Oriji, Ph.D. 9/1/92-6/30/94 Staff Scientist at NIH (address not known)

R. Ying, M.D. 6/1/91-6/30/96 Staff Scientist in a Biotech Company (Current address not known)

M. Muthalif, Ph.D. 9/9/94-2/28/01 Director, Business Dev & Operations, Martim Pharmaceuticals, San Francisco, CA

A. Ahmed, Ph.D. 7/1/96-6/30/98 Private Business, Washington D.C. M.A. Rifai, M.D. 2/1/97-3/31/98 Private Practice (address not known)

S. Fatima, Ph.D. 12/1/95-06/31/04 Staff Scientist, St. Jude Childrens Research Hospital, Memphis, TN.

J.H. Parmentier, Ph.D. 6/26/96-6/30/03 Staff Scientist, Boehinger Ingelheim Conneticut, USA, 7/1/03-6/30/2006 Assistant Prof., Univ. TN, Memphis A.E. Saeed, M.D. 9/1/96-8/31/01 Research Scientist, Div. of Rheumatology, Dept.

Med. University of Tennessee, Memphis (Deceased) F. Ljuca, M.D. 4/1/99 - 3/1/00 Assoc. Professor, University of Tuzla, Facility of Medicine,

Tuzla, Bosnia, Herzegovina R. Shouri, M.D. 6/1/99 - 5/31/00 Private Practice, Memphis, TN Z. Khandekar, M.D. 6/1/99 - 6/30/01 Private Practice, Jackson, MS M. A. Ahmed, M.D. 5/1/01 – 4/30/02 Private Practice, Little Rock, AK F. A. Yaghini, M.D. 6/1/01 – 3/31/12 Research Fellow, University of Tennessee, Memphis Z. Pavicevic, M. D. 9/1/01 – 8/31/07 Research Associate, University of Tennessee, Memphis G. Suglocki, M.D. 1/11/03- 8/31/03 Private Practice, Germany (address not known) E. Laventyev, M.D. 11/01/04- 11/30/07 Research Associate, University of Tennessee, Memphis S. A. Schaefer, M.D. 7/01/04-6/30/05 Private Practice, Oregon, USA Ghazala Mazhar, M.D. 7/01/05- 3/31/07 Private Practice, Memphis, TN B. Mugabe, Ph.D. 9/01/07 – 11/ 30/08 Staff Scientist, FDA Labs, Bethesda, Maryland C. Y. Song, PhD. 2/01/08 – Present Postdoctoral Fellow, University of Tennessee HSC, Memphis Naveen P. Reddy, Ph.D. 4/01/08 – 4/01/09 Postdoctoral Fellow, Vanderbilt University, Nashville, TN U. B. Ghafoor, M.D. 6/01/08 – 4/30/11 Residency in Medicine, University of Tennessee HSC, Memphis C.K. Buharalioglu, Ph.D. 9/08/07 - 9/08/09 Assistant Professor, University of Mersin, Mersin, Turkey

Sehn Sahan-Firat, D.V.M., 2/01/09 – 6/27/10 Assistant Professor, University of Ph.D. Mersin, Mersin, Turkey


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Brett L. Jennings, Ph.D. 09/01/08 – 08/31/13 Research Fellow, Kidney Transplant, Chattanooga, TN Nasreen Farjana, M.D. 05/01/08- 08/01/09 UT-Friend Research assistant, University of Tennessee HSC, Memphis, TN K. Das, M. D. 13/01/08-06/30/09 Fellow in Medicine, University of Tennessee HSC, Memphis,

TN K. Gafoor, M.D. 03/01/12-02/28/13 Residency in Medicine, Detroit, MI

A. Pingili, Ph.D. 02/01/13-Present Postdoctoral Fellow, University of Tennessee HSC, Memphis, TN

B. Shyamala Thiruna- 02/01/13- Present Postdoctoral Fellow, University of Tennessee HSC, Memphis vikkarasu, Ph.D. TN

Mehmet Kara, M.D. 09/23/13-03/31/14 Postdoctoral Fellow, University of Tennessee HSC, Memphis, TN

Kamalika Mukherjee, 11/13/2013-Present Postdoctoral Fellow, University of Tennessee HSC, Memphis Ph.D. TN Rhidima Grover, M.D. 11/01/14-Present Postdoctoral Fellow, University of Tennessee HSC, Memphis,

TN 3. Graduate, Medical, undergraduate and high School Students -Laboratory Rotation or Summer Internship

Yanti Mi 1997 Jennifer Bilyeu 1998 Shailaja Kalyankrishna 1998 Fang Li 1999 Young Gao 2001 Philip Smelcer (AHA Medical Student, Summer Fellow) 2002 Hassan Hussein 2002 Fang Li 2003 Sun Jiyuan 2003 Ravi shankar , M.D. 2003 Shams Tabrez Quazi 2003 Ravi Shanker, M.D. 2003 Harris Zafrullah, M.D. 2004 Waqas Chishti, M.D. 2004 Suneet Jian 2004 Bipul Baibhav 2004 Nourtan Abdeltawab 2004 Christopher M. Sharp (Summer Dental student) 2004 Bita Tabrizi (AHA, Medical Student, Summer Fellow) 2005 Todd Rutherford (AHA, Medical Student, Summer Fellow) 2006 Edward T. Stickle (AHA Medical Student 2006 Summer Fellow) 2007 Atta Ur Rehman Shahbaz (Resident) 2007 Benjamin S. Oberman (Summer Medical Student Fellow, 2008 AHA grant) Jingjing Li, B.Sc (Graduate student, Rotation) 2008 Stanislav Tolkachjov (AHA Summer Medical student) 2009 Tyler Buckley (AHA summer Medical student) 2010


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Jason Porter (AHA summer Medical student) 2010 Jarad L. Hopper (AHA summer Medical student 2011

4. Undergraduate Students – Training in Research During Summer Zaher Adl 1996 (College,ASPET Fellow) Jason Harper 1995 (College, ASPET Fellow) Zachary Maxwell 1995 (College, CBU Fellow) Brian Keplinger 1996 (College, NIH Fellow) Xavier Smith 1997 ( College, Minority Program) Matthew Dress 1998 (College,ASPET Fellow) Omar Z. Malik 1998 (High School, Young Memphis Scholar) Suzana F. Malik 1998 (College, CBU Fellow) Gautam Gandhi 1999 (College, ASPET Fellow) Elizabeth Luong 1999 (College, Graduate School Fellow) Kristie Yancy 1999 (College, Minority Program) Dinah Fordjour 1999 (College, Minority Program) Donna McDougal 1999 (College, McNair Fellow) Felecia Covington 1999 (College, McNair Fellow) Sarah Tanhai 1999 (Young Memphis Scholar) Shrei Crenshaw 2000 (College, Minority Program) Dzenana Idrizovic 2000 (College, NIH Fellow) Andrew Nishimoto 2000 (High School, Young Memphis Scholar) Monique Wiggins 2000 (College, Minority Program) Desiree Curry 2000 (College, Young Memphis Scholar) Azra Idrizovic 2001 (High School, Young Memphis Scholar) Dino Basic 2001 (College, ASPET Fellow) Monique Wiggins 2001 (College, NIH Fellow) Nauzene Mauzanene 2001 (High School, Young Memphis Scholar) Jay Gardner 2001 (College, NIH Fellow) Saeed Tanhai 2001 (High School, Young Memphis Scholar)

Ann Sweeny 2001 (College, Minority Program) Stephen Cash 2002 (College, Minority Cardiovascular Program) Reshma Patil 2002 (High School, Young Memphis Scholar)

Jiexin Dang 2002 (AHA High School Fellow) Nick Newsom 2002(College, ASPET Summer Fellow) Dino Basic 2002 (College, ASPET Summer Fellow) Nerma Basic 2003 (College, ASPET Summer Fellow) Amin Shazli 2003 (College, Biomedical Res. Trainee) Jessica Anthony 2003, (Minority Summer Student ) Tiffany Abdullahi 2003-(High School, Pre Science) Kyle Cox 2003 (AHA High School Fellow) Andrew Nishimoto 2004 (College, ASPET Summer Fellow) Nauzanene Jafari 2004 (College, ASPET Summer Fellow) Olivia McGregor 2004 (Minority Cardiovascular Program) Priya Patel 2005 (College, ASPET Summer Fellow) Neelam Khan 2005 (High School, Biomedical Science)


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CURRICULUM VITAE

Nevette Sample 2005 (High School, MinorityPre science I) Anmol Khan 2005 (Biomedical science) Ahmed Mahmood 2006 (College, Biomedical Science) Sarfraz Hyder 2006 (College, Biomedical Science) Saeed Tanhaee 2006 (College, Biomedical Science) Voosa Khan 2006 (College, MacNair) Tushina 2006 (High School, Pre Science 1) Neelam Khan 2007 (College, Biomedical Sciences) Dwylette Brownlee Reese 2007 (College, Minority Biomedical Sciences) Abdul Hameed Siddiqi 2008 (NIH Minority Summer Fellowship) Safaraz Nayeem Hyder 2008 (NIH Minority Summer Fellowship Elvis Marienga 2009 (College, Minority Biomedical Sciences) George Harris 2009 (NIH Minority Summer Fellowship) Mustafa Motiwala 2009 (High School Biomedical Research program) Amir Khan 2009 (High School Biomedical Research Program) Angela Gupta 2009 (High School Biomedical Research Program) Tusida Adris 2010 (High School-Biomedical Research Program) Larry Anderson 2010 (College Student, ASPET Fellow) Samill Meriwether 2010 (College student, Smart up Scholar, Minority) Tusida Adris 2010 (High School, Biomedical Research Program) Jonathan Li 2010 (High School-Biomedical Research Program) Matthew C. Hartzell 2011 (College Student, ASPET Fellow)

Jonathan Li 2011 (High School-Biomedical Research Program) Matthew C. Hartzell 2012 (College student-ASPET Fellow) Jarad Hopper 2012 (Medical student-NIH Fellow) Jeffery B. Copeland 2012 (Medical student, NIH Fellow) Michael E. May, Jr. 2012 (Medical student, Volunteer) Minja Dedic 2012(College Student, Biomedical Research Program) Salih Placo 2012 (High School, Biomedical Research Program) Omar Attabbaa 2012 (High School, Biomedical Research Program) Brijesh Kumar 2012 (High School, Biomedical Research Program) Salih Placo 2013 (High School, Biomedical Research Program) Maria Dopico 2013 (High School, Biomedical Research Program) Benjamin H. Ormeth 2013 (High School, Biomedical Research Program) Tusida Adris 2013 (College Student, Biomedical Research Program) Joseph Moore 2013 (College Student- ASPET Fellow) Vera Rymsha McGhee 2013 (Medical Student, AHA Fellow) Lewis Watson George 2013 (Medical Student, NIH Fellow) Prudhvi Budati 2014 (Medical Student, NIH Fellow) Joseph Cook 2014 (Medical Student, NIH Fellow) Ahmad Dhodi 2014 (College Student, Biomedical Research Program) George Ormseth 2014 (College Student, Biomedical Research Program) Karen Davidge 2014 (College Student, Biomedical Research Program) Latifa Alijuma 2014 (High School, Biomedical Research Program)


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CURRICULUM VITAE

A. Institutional Member of Animal Care Committee, 1973-1975, The Medical College of Wisconsin, Milwaukee Member of Advisory Committee, Use of G.C. Mass Spectrometer, 1980-Present, Biomedical Instrumentation,

1981-Present Member of Student Feedback Committee, 1976-1978, Neuroscience Module, The University of Tennessee,

Memphis Member of Graduate Program Review Committee, 1978-1980, The University of Tennessee, Memphis Departmental Committee on Graduate Studies 1979-1981 Co-Director - Departmental Journal Club, 1980-1992 Departmental Committee for Faculty Recruitment 1981 Organizer of Annual Fall Pharmacology Meeting at UT, 1981, 1982 and 1983 UTCHS Search Committee for The Chairman of Biochemistry 1982-83 Advisory Committee for Medical Students (M-1) 1983-2001 Member of the Committee for the John Jacob Abel Award in Pharmacology 1983 Chairman ad Hoc Search Committee for the Director of Interdisciplinary Program in Toxicology 1984 Tenure and Promotions Committee, Department of Pharmacology, 1984-1986 Tenure and Promotions Committee, School of Medicine, University of Tennessee, 1985-1989 Search Committee for the Faculty in Neurosciences, Department of Pharmacology, University of Tennessee, 1986-

87 Chairman, Advisory Committee for the recruitment of Faculty in Cardiovascular Pharmacology, Dept. of

Pharmacology, University of Tennessee, 1987-88 Advisory Committee for the Search of Chairman of Department of Physiology, University of Tennessee, 1987-88 Advisory Committee for the Faculty Recruitment in Pharmacology, Department of Pharmacology, University of

Tennessee, 1988-1989 Tenure and Promotions Committee, Department of Pharmacology 1987-1989 Chairman of Tenure and Promotions Committee, Department of Pharmacology 1988-1989 Advisory Committee for the Search of Associate Dean of Research, University of Tennessee, 1987-88 Research Council for the Health Science Center, University of Tennessee, 1988-1994 Policy Committee for the Research Council, University of Tennessee, 1989-1994 Departmental Advisory Committee for Search for Faculty, 1986-1989 Advisory Committee to the Dean of Pharmacy for the Search of Chairman of Pharmaceutics/Medicinal Chemistry,

1988-1992 Advisory Committee to the Dean of the College of Medicine for the Search of Chairman for the Department of

Anesthesiology, 1991 Member, Committee to the Chancellor, E. Eric Muirhead Hypertension Research Day, 1989-Present Member UTRC Memphis Advisory Board, 1991-2006 Member Faculty Senate, University of Tennessee, Memphis 1994-2006 Member Faculty Senate Subcommittee on Research 1994-2002 (Chairman, 1998-2002) Member Educational Council, University of Tennessee, 1994-1998 Member, Advisory Committee to the Dean of College of Medicine for the Review of Department of Psychiatry, The

University of Tennessee, Memphis, 1994-1998

Administrative and Service Function:


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CURRICULUM VITAE

Member Progress and Promotion Committee for Biomedical Sciences 1994-1998 Member Ad Hoc Committee for Academic Appeal, 1994 Member, Campus Support Services Council Subcommittee (Personnel) 1996-1998 Member, Intercultural Relations Committee, University of Tennessee, Memphis 1999-2002 Chairman, Departmental Advisory Committee for Faculty Search, 1999-2001 Coordinator - Departmental Graduate Student Journal Club, Fall Semester, 2000 Member of the Chancellors Roundtable of Distinguished Teachers, University of Tennessee, Memphis, 2001 –

Present Chairman, Faculty Senate Research Committee 1999-2002 Faculty Senate – Secretary – Treasurer (2002 – 2003) Member of the Research Committee, American Heart Association- Southeast Affiliate 2003-2007 Member of the Program Committee, National American Heart Association, Council for High Blood Pressure 2003-

Present Faculty Senate –President-Elect (2003-2004) Faculty Senate-President (2004-2005) Faculty Senate Past-President (2005-2006) Co-Chairman of the Chancellors Advisory Committee for Vice Chancellor for Research, 2005-2006. Member- Postdoctoral Fellow Advisory Committee 2007-2008 Departmental Advisory Committee for Search for Faculty, 2008 NIH Study Section (Ad Hoc, 2008) Member Evaluation Committee for COBRE Project at LSU Medical School, New Orleans, LA. 2003- Present Graduate Student Thesis Committee for:

Jennifer W. Childers, Department of Physiology, 1977-79

P. Hoffman, Department of Physiology, 1978-80

D. Diz, Department of Pharmacology, 1979-80

T. Mecca, Department of Pharmacology, 1980-82

S.M. Lanier, Department of Pharmacology, (Chairman) 1980-82

M. Hegazy, Department of Biochemistry, 1981-83

R. Frank, Department of Pharmacology, 1981-83

M. Johnson, Department of Pharmacology, 1982-84

B. Adler, Department of Pharmacology, 1982-84

C.L. Cooper, Department of Pharmacology, (Chairman) 1983-85

A.K. Paul, Department of Biochemistry, 1983-86

D.G. Beasley, Department of Physiology, 1985-87

M.B. Ravi, Department of Biochemistry, 1986-1989

B. Khan, Department of Pharmacology, 1987-1989

P. Akins, Department of Anatomy, Neuroscience Program, 1988-1990

C. Simkevich, Department of Pharmacology, 1988-1991

T. Robinson, Department of Physiology, 1989-1992


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CURRICULUM VITAE

W. Oellerich, Department of Pharmacology (Chairman), 1989-1992

L. Payne, Department of Physiology, 1990-1992

B. Smith, Department of Anatomy, Neuroscience Program, 1990-1992

C. Nebigil, Department of Pharmacology (Chairman), 1990-1992

L.H. Spinolo, Department of Pharmacology, 1990-1992

A.A. Book, Department of Anatomy and Neurobiology, 1991-1993

P. Hsu, Department of Physiology, 1990-1994

Jitai Deng, Department of Pharmacology, 1993-1995

H. Wright, Department of Pharmacology (Chairman), 1992-1996

K. Hong, Department of Pharmacology (Chairman), 1992-1996

N.A. Bayakly, Department of Biology, University of Memphis, 1993-1996

W.B. Thompson, Department of Pharmaceutics, College of Pharmacy, 1994-1996

J.W. Lester, Department of Physiology, 1995-1997

W. Wang, Department of Pharmacology, 1992-2001

P. Glen, Department of Physiology, 1997-1999

A. Willis, Department of Physiology, 1997-2001

Y. Zhang, Department of Physiology, 1997-2001

K. Shalaja, Department of Pharmacology (Chairman), 1998-2002

F. Li, Department of Pharmacology (Chairman), 2000-2005

N. Suvarna, Department of Pharmacology, 2001 - 2002

Y. Zhao, Department of Pharmacology, 2001 – 2003

J. Kane, Department of Pharmacology, 2001- 2002

Y. Zhang, Department of Pharmacology , 2003-2005

A. C. Tomar, Department of Physiology, 2003- 2007.

S. Lattimer, Department of Molecular Sciences, 2007-2010

K. Guru, Department of Pharmacology, 2010- 2014

N. Khan, Department of Pharmacology (Chairman), 2010- 2014

B. Professional a) Study Section and Site Visits

Member NIH Cardiovascular Renal Study Section (Ad Hoc) 1979

Member NIH Clinical Sciences Review Group B, 1980

Consultant to Kidney Foundation of Canada for Grant Review, 1981

Consultant to NIH General Medicine B Study Section for a Grant Review, 1982

Consultant to NIH Centers and Special Projects Review Section, R.B., DEA for a Grant Review, 1982


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CURRICULUM VITAE

Member of the Site Visit Team NIH-Neurological Disorders and Stroke, 1983

Member American Heart Association - Tennessee Affiliate; Research Committee, 1982-86

Member NIH Experimental Cardiovascular Sciences Study Section (Ad Hoc) 1985

Member NIH Experimental Cardiovascular Sciences Study Section, 1987-1991(Regular Member)

NIH Experimental Cardiovascular Sciences Study Section, 1991-present (Reserve Member)

Member of the NIH Site Visit Team for Program Project - Pathogenesis of Severe Pulmonary Hypertension,

May, 1994

Member of the NIH Site Visit Team for Program Project - FGR-Secretory Pathway, February, 1994

Member of the Site Visit Team NIH-Vasopressor Mechanisms, 1998

Member NIH Study Section Program Project- Glucose, Insulin, Vascular Disease, NHBLI, 2006

b) Editorial Services

1. Referee Editor

American Journal of Physiology, Circulation Research, Science, Journal of Pharmacology and Experimental

Therapeutics, Journal of Clinical and Experimental Hypertension, Canadian Journal of Physiology and

Pharmacology, Prostaglandins, Blood Vessels, Life Sciences, Society for Experimental Biology and Medicine

2. Editoral Board

a. Journal of Clinical and Experimental Hypertension, 1978-2000

b. Journal of Pharmacology and Experimental Therapeutics, 07/01/81-06/31/90

c. General Pharmacology – The Vascular System 1999-2010

3. Editor for Specific Fields a. Journal of Pharmacology and Experimental Therapeutics

Prostaglandins, Leukotrienes, and Other Eicosanoids, 07/01/90-1998

b. Prostaglandins and Other Lipid Mediators (Renal Section), 12/01/96-2003.


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CURRICULUM VITAE

A. Journal Articles

1. Malik, K.U.: Determination of sodium salicylate in the presence of simulated gastric and intestinal fluid. Acta

Pharmaceutika Jugoslavika, 15:9-15, 1965. 2. Stivic, I., Malik, K.U. and Benzinger, F.: Contribution to the investigation of acidoresistent tablet coatings. Acta

Pharmaceutika Jugoslavika, 15:59-68, 1965. 3. Malik, K.U. and Hukovic, S.: Passage of biogenic amines across the intestine and their effect on the organs of

abdominal cavity in vitro. Medicinski Vijesnik, 1-2, 73-78, 1966. 4. Malik, K.U. and Hukovic, S.: Passage of glucose across the control and damaged intestinal wall in the presence of

some active substances. Medicinski Vijesnik, 3-4:51-57, 1966. 5. Malik, K.U. and Hukovic, S.: The effect of stimulation of autonomic nerves on the passage of sodium salicylate

across the intestinal tract in vitro. Proceedings of the Society of Pediatrics (Bosnia and Herzegovina), pp. 209-213, May, 1966.

6. Hukovic, S. Malik, K.U. and Peric, B.: Accessory means in therapy with special reference to their effects on the absorption of drugs. Proceedings of the Society of Pediatrics (Bosnia and Hercegovina), pp. 201-208, May 1966.

7. Hukovic, S., Malik, K.U. and Smajkic, S.: The inhibitory effect of alcohol on nerve transmission of isolated innervated esophagus, ileum, urinary bladder and vas deferens. Journal of Alcohol and Alcoholism, 3:1-7, 1967.

8. Bobarevic, B., Malik, K.U., Nikolin, B. and Stern, P.: Pharmacological properties of some aminoxycarboxylic acids. Acta Pharmaceutika Jugoslavika, 19:55-59, 1969.

9. Malik K.U. and Muscholl, E.: The effect of α-methyl dopa on the vasoconstrictor responses of the rat mesenteric artery preparation to adrenergic nerve stimulation. Arzeneimittel Forschung, 19:1111-1113, 1969.

10. Malik, K.U. and Muscholl, E.: Effect of sympathomimetic amines on the responses of the perfused mesenteric artery preparation to adrenergic nerve stimulation. Arzneimittel Forschung, 19:1574-1579, 1969.

11. Malik K.U. and Ling, G.M.: Modification by acetylcholine of the responses of rat mesenteric arteries to sympathetic stimulation. Circulation Research, 25:1-9, 1969.

12. Malik, K.U.: Effect of temperature changes on the tone of perfused mesenteric arteries of rat and on the

perfusion pressure responses to sympathetic nerve stimulation and infused noradrenaline. Journal of Pharmacy and Pharmacology, 21:472-473, 1969.

13. Malik, K.U. and Ling, G.M.: The effect of 1,1-dimethyl-4-phenyl-piperazinium on the response of mesenteric arteries to sympathetic nerves stimulation. Journal of Pharmacy and Pharmacology, 21:514-519, 1969.

14. Malik, K.U.: The potentiation by anticholinesterases of the responses of rat mesenteric arteries to sympathetic stimulation. Circulation Research, 27:647-655, 1970.

15. Malik, K.U.: Effect of (±) dihydroxypsuedoephedrine (DHPE) on adrenergic transmission in mesenteric arteries. British Journal of Pharmacology, 41:352-360, 1971.

16. Malik, K.U. and McGiff, J.C.: Modification by choline of adrenergic transmission in rat mesenteric arteries. British Journal of Pharmacology, 43:776-783, 1971.

17. McGiff, J.C., Terragno, N.A., Malik, K.U. and Lonigro, A.J.: Release of a prostaglandin E-like substance from canine kidney by bradykinin. Circulation Research, 31:36-43, 1972.

18. Malik, K.U. and McGiff, J.C.: Effects of ganglionic blocking agents on adrenergic transmission in rat mesenteric arteries. American Journal of Physiology, 223:1210-1215, 1972.

19. McGiff, J.C., Crowshaw, K., Terragno, N.A., Malik, K.U. and Lonigro, A.J.: Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance. Clinical Sciences, 42:223-233, 1972.

Publications:


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CURRICULUM VITAE

20. Terragno, N.A., Lonigro, A.J., Malik, K.U. and McGiff, J.C.: The relationship of the renal vasodilator action of bradykinin to the release of a prostaglandin E-like substance. Experientia, 28:437-439, 1972.

21. Lonigro, A.J., Terragno, N.A., Malik, K.U. and McGiff, J.C.: Differential inhibition by prostaglandins of the renal actions of pressor stimuli. Prostaglandins, 3:595-606, 1973.

22. Malik, K.U. and McGiff, J.C.: Relationship of glucose metabolism to adrenergic transmission in rat mesenteric arteries. Effects of glucose deprivation, glucose metabolites, and changes in ionic composition on adrenergic mechanisms. Circulation Research, 35:553-574, 1974.

23. Malik, K.U. and McGiff, J.C.: Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney. Circulation Research, 36:599-609, 1975.

24. Malik, K.U. and Nasjletti, A.: Facilitation of adrenergic transmission by locally generated angiotensin II in rat mesenteric arteries. Circulation Research, 38:26-30, 1976.

25. Malik, K.U., Ryan, P. and McGiff, J.C.: Modulation by prostaglandins E1, E2, indomethacin and arachidonic acid of the vasoconstrictor responses of the isolated perfused rabbit and rat mesenteric arteries to adrenergic stimuli. Circulation Research 39:163-168, 1976.

26. McGiff, J.C., Malik, K.U. and Terragno, N.A.: Prostaglandins as determinants of vascular reactivity. Federation Proceedings, 35:2382-2387, 1976.

27. Hamamdzic, M. and Malik, K.U.: Role of prostaglandins in adrenergic transmission of isolated perfused rat pancreas. American Journal of Physiology, 232(2):F201-F209, 1977.

28. Malik, K.U.: Prostaglandin mediated inhibition of vasoconstrictor responses of the isolated perfused rat splenic vasculature of adrenergic stimuli. Circulation Research, 43:225-233, 1978.

29. Malik, K.U.: Prostaglandins - modulation of adrenergic nervous system. Federation Proceedings, 37:203-207, 1978.

30. Wong, P. Y-K, McGiff, J.C., Sun, F.F. and Malik, K.U.: Pulmonary metabolism of prostacyclin (PGI2) in the rabbit. Biochemical and Biophysical Research Communications, 83:731-738, 1978.

31. Malik, K.U. and Nasjletti, A.: Attenuation by bradykinin of the adrenergically induced vasoconstrictor responses of the isolated perfused rabbit kidney: Relationship to prostaglandins. British Journal of Pharmacology, 67:269-275, 1979.

32. Wong, P.Y-K, McGiff, J.C., Cagen L., Malik, K.U. and Sun, F.F.: Metabolism of prostacyclin in the rabbit kidneys. Journal of Biological Chemistry, 254:12-14, 1979.

33. Nasjletti, A. and Malik, K.U.: Relationship between the kallikrein-kinin system and prostaglandin systems. Life Sciences, 25:99-110, 1979.

34. Khan, M.T. and Malik, K.U.: Inhibitory effect of adenosine and adenine nucleotides on potassium evoked efflux of 3H-norepinephrine from the isolated rat heart: Lack of relationship to prostaglandins. British Journal of Pharmacology, 68:551-561, 1980.

35. Hidaka, T., Wong, P.Y-K and Malik, K.U.: Metabolism of arachidonic acid in the isolated spleen of rabbit.

Prostaglandins, 19:805-817, 1980. 36. Hidaka, T. and Malik, K.U.: Release of prostaglandins evoked by neurohormonal stimuli in the isolated spleen of

rabbit. European Journal of Pharmacology, 62:970-105, 1980. 37. Wong, P.Y-K, Malik, K.U., Desiderio, D.M., McGiff, J.C. and Sun, F.F.: Hepatic metabolism of prostacyclin (PGI2) in

the rabbit: Formation of a potent novel inhibitor of platelet aggregation. Biochemical and Biophysical Research Communications, 93:486-494, 1980.

38. Chiba, S. and Malik, K.U.: Mechanism of the chronotropic effects of prostacyclin in the dog: Comparison with the actions of prostaglandin E2. The Journal of Pharmacology and Experimental Therapeutics, 213:261-266, 1980.

39. Malik, K.U., Susic, H . and Nasjletti, A.: Modulation of adrenergic neuroeffector events in the renal vasculature: Role of prostaglandins. Progress in Biochemical Pharmacology, 17:108-115, 1980.


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40. Susic, H., Nasjletti, A., Malik, K.U.: Inhibition by bradykinin of the vascular effects of pressor hormones in the canine kidney: Relationship to prostaglandins. Clinical Science and Molecular Medicine, 59:145A-148S, 1980.

41. Chiba, S. and Malik, K.U.: Prostaglandins do not modulate the positive chronotropic and inotropic effects of sympathetic nerve stimulation and injected norepinephrine in the isolated blood perfused canine atrium. Life Sciences, 28:687-695, 1981.

42. Malik, K.U. and Nasjletti, A.: Inhibitory action of bradykinin on release of the adrenergic transmitter in the isolated lapine kidney. Experientia, 37:496-497, 1981.

43. Shaffer, J.E., Cagen, L.M. and Malik, K.U.: Attenuation by acetaminophen of arachidonic acid-induced coronary vasodilatation and output of prostaglandins in the isolated rat heart. European Journal of Pharmacology, 72:P57-61, 1981.

44. Nasjletti, A. and Malik, K.U.: The renal prostaglandin relationship: Implication on renal function. Kidney International, 19:860-868, 1981.

45. Susic, H., Nasjletti, A. and Malik, K.U.: Inhibition by bradykinin of the vascular action of angiotensin II in the dog kidney. Journal of Pharmacology and ExperimentalTherapeutics, 218:102-107, 1981.

46. Susic, H., Nasjletti, A. and Malik, K.U.: Bradykinin effects on adrenergic transmission in the canin kidney: Relation to prostaglandins. American Journal of Physiology, 241:R146-R151, 1981.

47. Susic, H. and Malik, K.U.: Prostacyclin and prostaglandin E2 effects on adrenergic transmission in the kidney of anesthetized dog. Journal of Pharmacology and Experimental Therapeutics, 218: 588-592, 1981.

48. Malik, K.U. and Wong, P.Y-K: Leukotriene C4. The major lipoxygenase metabolite of arachidonic acid in dog spleen. Biochemical and Biophysical Research Communication, 103:511-519, 1981.

49. Susic, H. and Malik, K.U.: Attenuation by arachidonic acid of the effect of vasoconstrictor stimuli in the canine kidney. Journal of Pharmacology and Experimental Therapeutics, 219:377-382, 1981.

50. Nasjletti, A. and Malik, K.U.: Interrelationships among prostaglandins and vasoactive substances. Medical Clinics of North America, 65:811-887, 1981.

51. Khan, M.T. and Malik, K.U.: Modulation by prostaglandins of the release of 3-H noradrenaline evoked by potassium and nerve stimulation in the isolated rat heart. European Journal of Pharmacology, 78:213-218, 1982.

52. Nasjletti, A. and Malik, K.U.: Interrelations between prostaglandins and vasoconstrictor hormones: Contribution to blood pressure regulation. Federation Proceedings, 41:2394-2399, 1982.

53. Homma, T. and Malik, K.U.: Effect of prostaglandins on pancreatic circulation in the anesthetized dogs. Journal of Pharmacology and Experimental Therapeutics, 222:623-628, 1982.

54. Lanier, S.M. and Malik, K.U.: Attenuation by prostaglandins of the faciliatory effect of angiotensin II at adrenergic prejunctional sites in the isolated Krebs perfused rat heart. Circulation Research, 51:594-601, 1982.

55. Shaffer, J.E. and Malik, K.U.: Enhancement of prostaglandin output during activation of β-adrenoceptors in the isolated rabbit heart. Journal of Pharmacology and Experimental Therapeutics, 223:729-735, 1982.

56. Homa, T. and Malik, K.U.: Effect of secretion and caerulein in the canine pancreas: Relation to prostaglandins. American Journal of Physiology, 244:G660-G667, 1983.

57. Böke, T. and Malik, K.U.: Enhancement by locally generated angiotensin II of release of the adrenergic transmitter in the isolated rat kidney. Journal of Pharmacology and Experimental Therapeutics, 226:900-907, 1983.

58. Lanier, S.M. and Malik, K.U.: Faciliation of adrenergic transmission in the canine heart by intracoronary infusion

of angiotensin II: Effect of prostaglandin synthesis inhibition. Journal of Pharmacology and Experimental Therapeutics, 227:676-682, 1983.

59. Inokuchi, K. and Malik, K.U.: Attenuation by prostaglandins of adrenergically-induced renal vasoconstriction in anesthetized rats. American Journal of Physiology, 246 (Regulatory Integrative Comp. Physiol. 15): R228-R238, 1984.


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CURRICULUM VITAE

60. Shaffer, J.E. and Malik, K.U.: Mechanism of action of arachidonic acid in the isolated perfused rat heart. Canadian Journal of Physiology and Pharmacology, 62:551-558, 1984.

61. Inokuchi, K. and Malik, K.U.: Inhibition by bradykinin of renal adrenergic transmission in anesthetized rats. American Journal of Physiology, 246 (Renal Fluid Electrolyte Physiol. 15): F387-F394, 1984.

62. Cooper, C.L. and Malik, K.U.: Mechanism of action of vasopressin on prostaglandin synthesis and vascular function in the isolated rat kidney. Journal of Pharmacology and Experimental Therapeutics, 229:139-147, 1984.

63. Cooper, C.L. and Malik, K.U.: Effect of glucocorticoids on their vascular reactivity to vasoactive hormones in the isolated rat kidney: Lack of relationship to prostaglandins. British Journal of Pharmacology, 82:679-688, 1984.

64. Cooper, C.L., Schaffer, J.E. and Malik, K.U.: Mechanism of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney: Effect of Ca2+ antagonists and calmodulin inhibitors. Circulation Research, 51:594-601, 1985.

65. Iwatsuki, K., Homma, T. and Malik, K.U.: Contribution of prostaglandins to dopamine actions in the pancreas of anesthetized dogs. American Journal of Physiology, 248 (Gastrointest. Liver Physiol. 11): G110-G117, 1985.

66. Cooper, C.L. and Malik, K.U.: Prostaglandin synthesis and renal vasoconstriction elicited by adrenergic stimuli are linked to activation of alpha-1 adrenergic receptors in the isolated rat kidney. Journal of Pharmacology and Experimental Therapeutics, 233:24-31, 1985.

67. Lanier, S.M. and Malik, K.U.: Inhibition by prostaglandins of adrenergic transmission in the left ventricular myocardium of anesthetized dogs. Journal of Cardiovascular Pharmacology, 7:653-659, 1985.

68. Iwatsuki, K., Homma, T. and Malik, K.U.: Permissive role of prostaglandins in the action of bradykinin on the pancreas of anesthetized dogs. Journal of Pharmacology and Experimental Therapeutics, 233:700-706, 1985.

69. Wong, P. Y-K, Malik, K.U., Taylor, B.M., Schneider, W.P., McGiff, J.C. and Sun, F.F.: Expoxidation of prostacyclin in the rabbit kidney. Journal of Biological Chemistry, 260:9150-9153, 1985.

70. Weis, M.T. and Malik, K.U.: Beta-adrenergic stimulated prostaglandin synthesis in the isolated rabbit heart: Relationship to extra- and intracellular calcium. Journal of Pharmacology and Experimental Therapeutics, 235:178-185, 1985.

71. Iijima, F. and Malik, K.U.: Mesenteric vascular reactivity in dexamethasone treated hypertensive rats. Hypertension 7:783-790, 1985.

72. Cooper, C.L. and Malik, K.U.: Contribution of Ca++ and calmodulin to the action of norepinephrine on renal prostaglandin synthesis and vascular tone. Journal of Pharmacology and Experimental Therapeutics, 236:424-431, 1986.

73. Weis, M.T. and Malik, K.U.: Regulation by calcium of arachidonic acid metabolism in the isolated perfused rabbit heart. Circulation Research, 59:694-703, 1986.

74. Van Sickle, W.A., Wilcox, H.G., Malik, K.U. and Nasjletti, A.: HDL-induced cardiac PGI2 synthesis in vitro. Relationship to cardiac arachidonate mobilization. Journal of Lipid Research, 27:517-522, 1986.

75. Cooper, C.L. and Malik, K.U.: Evidence that bradykinin stimulates renal prostaglandin synthesis by a mechanism distinct from that of other vasoactive substances. Circulation Research, 60:914-922, 1987.

76. Mohy El-Din, M.M. and Malik, K.U.: Mechanism of norepinephrine release elicited by renal nerve stimulation, veratridine and potassium chloride in the rat-isolated kidney. Journal of Pharmacology and Experimental Therapeutics, 243:76-85, 1987.

77. Iijima, F. and Malik, K.U.: Contribution of vasopressin in dexamethasone-induced hypertension in rats. Hypertension, 11:I-42-I-46, 1988.

78. Jaiswal, N. and Malik, K.U.: Prostaglandin synthesis elicited by cholinergic stimuli is mediated by activation of M2 muscarinic receptors in rabbit heart. Journal Pharmacology and Experimental Therapeutics, 245:59-66, 1988.

79. Mohy El-Din, M.M. and Malik, K.U.: Mechanism of norepinephrine release elicited by Na+-K+ adenosine triphosphatase inhibition in the isolated rat kidney: Involvement of voltage-dependent Ca++ Channels. Journal of Pharmacology and Experimental Therapeutics, 245:436-443, 1988.


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CURRICULUM VITAE

80. Malik, K.U.: Interaction of arachidonic acid metabolites and adrenergic nervous system. American Journal of Medical Sciences, 295:280-286, 1988.

81. Mohy El-Din, M.M. and Malik, K.U.: Differential effect of ω-conotoxin on release of the adrenergic transmitter and the vasoconstrictor response to noradrenaline in the isolated rat kidney. British Journal of Pharmacology, 94:355-362, 1988.

82. Mohy El-Din, M.M. and Malik, K.U.: Neuropeptide Y stimulates renal prostaglandin synthesis in the isolated rat kidney: Contribution of Ca++ and calmodulin. Journal of Pharmacology and Experimental Therapeutics, 246:479-484, 1988.

83. Jaiswal, N., Lambrecht, G., Mutschler, E. and Malik, K.U.: Contribution of M2α and M2β muscarinic receptors to the action cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart. Journal of Pharmacology and Experimental Therapeutics, 247:104-113, 1988.

84. Weis, M.T. and Malik, K.U.: Uptake and hormonally induced hydrolysis of [3H] phosphatidyl choline in the isolated rabbit heart. Journal of Pharmacology and Experimental Therapeutics, 248:614-620, 1989.

85. Malik, K.U., Weis, M.T. and Jaiswal, N.: Mechanism of action of adrenergic and cholinergic stimuli on cardiac prostaglandin synthesis. Advances in Prostaglandins, Thromboxane and Leukotriene Research, 19:327-330, 1989.

86. Weis, M.T. and Malik, K.U.: Influence of mono- and divalent cations on the cardiac metabolism of arachidonic acid. Prostaglandins, 37:707-723, 1989.

87. Jaiswal, N., Lambrecht, G., Mutschler, E., and Malik, K.U.: Effect of M2-muscarinic receptor antagonist 4-DAMP on prostaglandin synthesis and mechanical function in the isolated rabbit heart. General Pharmacology, 20:497-502, 1989.

88. Williams, Jr., J.L. and Malik, K.U.: Inhibitory modulation by cAMP of isoproterenol-induced prostacycline synthesis in rabbit heart. American Journal of Physiology, 257:R771-R780, 1989.

89. Schwartz, D.D. and Malik, K.U.: Renal periarterial nerve stimulation-induced vasoconstriction at low frequencies is primarily due to release of a purinergic transmitter in the rat. Journal of Pharmacology and Experimental Therapeutics, 250:764-771, 1989.

90. Sehic, E. and Malik, K.U.: Influence of protein kinase C activators on vascular tone and adrenergic neuroeffector events in the isolated rat kidney. Journal of Pharmacology and Experimental Therapeutics, 251:634-639, 1989.

91. Adeagbo, A.S.O. and Malik, K.U.: Mechanism of vascular actions of prostacylin in the rat isolated perfused mesenteric arteries. Journal of Pharmacology and Experimental Therapeutics, 252:26-34, 1989.

92. Jaiswal, N. and Malik, K.U.: Prostacyclin synthesis elicited by cholinergic agonists is linked to activation of M2α and M2β muscarinic receptors in the rabbit aorta. Prostaglandins, 39:267-280, 1990.

93. Sehic, E. and Malik, K.U.: Effect of protein kinase C inhibitors on the actions of phorbol esters on vascular tone and adrenergic transmission in the isolated rat kidney. Journal of Pharmacology and Experimental Therapeutics, 253:497-507, 1990.

94. Adeagbo, A.S. and Malik, K.U.: Endothelium-dependent and BRL 34915-induced vasodilation in rat isolated perfused mesenteric arteries:role of G-proteins, K+ and calcium channels. British Journal of Pharmacology, 100:427-434, 1990.

95. Nebigil, C. and Malik, K.U.: Prostaglandin synthesis elicited by adrenergic stimuli in rabbit aorta is mediated via alpha-1 and alpha-2 adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics, 254:633-640, 1990.

96. Schwartz, D.D. and Malik, K.U.: Prazosin-sensitive prejunctional α2-adrenergic receptor modulates release of the adrenergic transmitter elicited by periarterial nerve stimulation in the rat kidney. Annals of New York Academy of Sciences, 604:639-642, 1990.

97. Williams, Jr., J.L. and Malik, K.U.: Forskolin stimulates prostaglandin synthesis in rabbit heart by a mechanism that requires calcium and is independent of cyclic AMP. Circulation Research, 67:1247-1256, 1990.


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CURRICULUM VITAE

98. Weis, M.T., Palazzo, A.J., Williams, Jr. J.L., and Malik, K.U.: Uptake, incorporation and metabolism of [3H]triolein in the isolated perfused rabbit heart. Lipids, 25:497-503, 1990.

99. Jaiswal, N. and Malik, K.U.: Methoctramine, new cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in rabbit heart. European Journal of Pharmacology, 192:63-70, 1991.

100. Palazzo, A.J., Malik, K.U., and Weis, M.T.: Vasopressin stimulates the mobilization and metabolism of triacylglycerol in the isolated perfused rabbit heart. American Journal of Physiology, 260:H604-H612, 1991.

101. Adeagbo, A.-S.O. and Malik, K.U.: Contribution of K+ channels to arachidonic acid-induced endothelium

dependent vasodilation in rat isolated perfused mesenteric arteries. Journal of Pharmacology and Experimental Therapeutics, 258:452-458, 1991.

102. Jaiswal, N., Lambrecht, G., Mutschler, E., Tacke, R., and Malik, K.U.: Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. Journal of Pharmacology and Experimental Therapeutics, 258:842-850, 1991.

103. Jaiswal, N., Jaiswal, R.K., and Malik, K.U.: Muscarinic receptor-mediated prostacyclin and cGMP synthesis in cultured vascular cells. Molecular Pharmacology, 40:101-106, 1991.

104. Schwartz, D.D. and Malik, K.U.: Mechanism of neurotransmitter release elicited by the preferential α1-adrenergic receptor agonist phenylephrine in superfused superior cervical ganglion cells in culture. Neurochemistry, 57:831-838, 1991.

105. Cano, C. and Malik, K.U.: Adenosine receptor-mediated alterations in prostacyclin production and cardiac function in the isolated rabbit heart. Journal of Pharmacology and Experimental Therapeutics, 261:660-668, 1992.

106. Nebigil, C. and Malik, K.U.: Prostaglandin synthesis elicited by adrenergic stimuli is mediated via alpha-2C and alpha-1A adrenergic receptors in cultured smooth muscle cells of rabbit aorta. Journal of Pharmacology and Experimental Therapeutics, 260:849-858,1992.

107. Cano, C., Qureshi, Z., and Malik, K.U.: Contribution of adenosine to isoproterenol-stimulated prostacyclin

production in rabbit heart. American Journal of Physiology, 263:H218-H225, 1992. 108. Schwartz, D.D. and Malik, K.U.: Characterization of prejunctional alpha 2-adrenergic receptor modulation of

adrenergic transmitter release in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics, 261:1050-1055, 1992.

109. Lew, D.B., Nadel, G.L., and Malik, K.U.: Prostaglandin E2 synthesis elicited by adrenergic stimuli in guinea-pig trachea is mediated primarily via activation of β2 adrenergic receptors. Prostaglandins, 44:399-412, 1992.

110. Lew, D.B., Nebigil, C., and Malik, K.U.: Dual regulation by cAMP of β-hexosaminidase-induced mitogenesis in bovine tracheal myocytes. American Journal of Respiratory Cell and Molecular Biology, 7:614-619, 1992.

111. Nebigil, C. and Malik, K.U.: Comparison of signal transduction mechanisms of alpha-2C and alpha-1A-adrenergic receptors stimulated prostaglandin synthesis. Journal of Pharmacology and Experimental Therapeutics, 263:987-996, 1992.

112. Schwartz, D.D. and Malik, K.U.: Cyclic AMP modulates, but does not mediate the inhibition of [3H]norepinephrine release by activation of alpha-2 adrenergic receptors in cultured rat ganglion cells. Neurosciences, 52:107-113, 1993.

113. Schwartz, D.D. , Williams, J.L., and Malik, K.U.: Contribution of calcium to isoproterenol-stimulated lipolysis in the isolated perfused rabbit heart. American Journal of Physiology, 265:E439-E445, 1993.

114. Nebigil, C., and Malik, K.U.: Alpha-adrenergic receptor subtypes involved in prostaglandin synthesis are coupled to Ca2+ channels through a pertussis toxin-sensitive guanine nucleotide-binding protein. Journal of Pharmacology and Experimental Therapeutics, 266:1113-1124, 1993.


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CURRICULUM VITAE

115. Oellerich, W.F. and Malik, K.U.: Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics, 266:1321-1329, 1993.

116. Oellerich, W.F., Schwartz, D.D., and Malik, K.U.: Neuropeptide Y inhibits adrenergic transmitter release in cultured rat superior cervical ganglion cells by restricting the availability of calcium through a pertussis toxin-sensitive mechanism. Neuroscience, 60:495-502, 1994.

117. Sehic, E., Ruan, Y., and Malik, K.U.: Attenuation by α, β-methylenadenosine-5'-triphosphate of periarterial nerve stimulation-induced renal vasoconstriction is not due to desensitization of purinergic receptors. Journal of Pharmacology and Experimental Therapeutics, 271:983-992, 1994.

118. Cano, C., Slavik, K.J., and Malik, K.U.: Loss of adenosine-induced negative inotropic effect in hyperexcited rabbit hearts: Relationship to PKC. American Journal of Physiology, 265:H1037-H1044, 1995.

119. Wright, H.M. and Malik, K.U.: Prostacyclin synthesis elicited by endothelin-1 in rat aorta is mediated via influx of calcium and independent of protein kinase C. Hypertension, 26:1035-1040, 1995.

120. Kan, H., Ruan, Y., and Malik, K.U.: Localization and characterization of the subtype(s) of muscarinic receptors

involved in prostaglandin synthesis in rabbit heart. Journal of Pharmacology and Experimental Therapeutics 276:934-941, 1996.

121. Ruan, Y., Kan, H., and Malik, K.U.: Modulation by cyclic AMP of β-adrenergic receptor stimulated prostacyclin synthesis in rabbit ventricular myocytes. Journal of Pharmacology and Experimental Therapeutics 278:489-489, 1996.

122. Wright, H.M. and Malik, K.U.: Prostacyclin synthesis elicited by endothelin-1 in rat aorta is mediated via phospholipase D and not phospholipase C or A2 activation. Circulation Research 79:271-276, 1996.

123. Ruan, Y., Kan, H., Cano., C., and Malik, K.U.: Modulation of beta adrenergic receptor stimulated lipolysis in the heart by prostaglandins. American Journal of Physiology 271 (Endocrinol.Metab.-34):E556-E562, 1996.

124. Kan, H., Ruan, Y., and Malik, K.U.: Involvement of mitogen-activated protein kinase and translocation of cytosolic phospholipase A2 to the nuclear envelope in acetylcholine induced prostacyclin synthesis in rabbit coronary endothelial cells. Molecular Pharmacology 50:1139-1147, 1996.

125. Muthalif, M.M., Benter, I.F., Uddin, M.R., and Malik, K.U.: CaM kinase IIa mediates activation of MAP kinase and cytosolic phospholipase A2 in norepinephrine induced arachidonic acid release in rabbit aortic smooth muscle cells. Journal of Biological Chemistry 271:30149-30157, 1996.

126. Sehic, E., Ruan, Y., and Malik, K.U.: Mechanism of resistance to alpha-adrenergic receptor antagonists of renal nerve stimulation induced vasoconstriction at low frequences. Cardiovascular Pharmacology 29:97-108, 1997.

127. Lew, B., Roberts, E., Wright, H.M., and Malik, K.U.: Contribution of protein kinase C α and γ to β-hexasaminidase-induced airway smooth muscle proliferation. American Journal of Physiology 272:Lung Cellular Molecular Physiology (16):L-639-L643, 1997.

128. Ruan, Y., Kan, H., and Malik, K.U.: Beta-adrenergic receptor stimulated prostacyclin synthesis in rabbit coronary endothelial cells is mediated by selective activation of phospholipase D: Inhibition by adenosine 3' 5'-cyclic monophosphate. Journal of Pharmacology and Experimental Therapeutics 281:1038-1046, 1997.

129. Kan, H., Ruan, Y., Malik, K.U.: Signal transaction mechanism(s) involved in prostacyclin production elicited by acetylcholine in the coronary endothelial cells of rabbit heart. Journal of Pharmacology and Experimental Therapeutics 282:113-122, 1997.

130. Muthalif, M.M., Benter, I.F., Uddin, M.R., Harper, J.L., and Malik, K.U.: Signal transduction mechanisms involved in angiotensin-(1-7) stimulated arachidonic acid release and prostanoid synthesis in rabbit vascular smooth muscle. A Comparison to Angiotensin II. Journal of Pharmacology and Experimental Therapeutics 284:388-398, 1998.


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CURRICULUM VITAE

131. Ruan, Y., Kan, H., Parmentier, J-H., Fatima, S., Allen, L.F., and Malik, K.U.: Alpha1 adrenergic receptor-stimulated arachidonic acid release is mediated by selective activation of phospholipase D in rat-1 fibroblasts: Inhibition by protein kinase A. Journal of Pharmacology and Experimental Therapeutics 284:576-585, 1998.

132. Uddin, M.R., Muthalif, M.M., Karzoun, N.A., Benter, I.F., and Malik, K.U.: Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling. Hypertension 31:242-247, 1998.

133. Muthalif, M.M., Benter, I.F., Karzoun, N., Fatima, S., Harper, J., Uddin, M.R., and Malik, K.U.: 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. Proceedings of National Academy of Sciences 95:12701-12706, 1998.

134. Balestrieri, M.L., Malik, K.U., Balestrieri, C., and Lee, T-c.: Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. Prostaglandins and Other Lipid Mediators 56:363-375, 1998.

135. Lew, D.B., Dempsey, B.K., Zhao, Y., Muthalif, M., Fatima, S., and Malik, K.U.: β-Hexosaminidase-induced activation of p44142 mitogen activated protein kinase is dependent on p4 Ras and protein kinase c and mediates bovine airway smooth muscle proliferation. American Journal of Respiration and Cellular Molecular Biology 21:111-118, 1999.

136. Ekinci, F.J., Malik, K.U., and Shea, T.B.: Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cell to β-amyloid. Journal of Biological Chemistry 274:30322-30327, 1999.

137. Muthalif, M., Benter, I.F., Khandekar, Z., Gaber, L., Estes, A., Malik, S., Manne, V., and Malik, K.U.: Contribution

of Ras GTPase/MAP kinase and cytochrome P-450 metabolites to deoxycorticosterone salt-induced hypertension. Hypertension 35:457-463, 2000

138. Muthalif, M.M., Parmentier, J-H., Benter, I.F., Karzoun, N., Ahmed, A., Khandekar, Z., Adl, M.Z., Bourgoin, S., and Malik, K.U.: Ras/mitogen activated protein kinase mediates norepinephrine-induced activation of phospholipid D in rabbit aortic smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 293:268-274, 2000.

139. Muthalif, M.M., Karzoun, N.A., Gaber, L., Khandekar, Z., Benter, I.F., Saeed, A.E., Parmentier, J-H., Estes, A., and Malik, K.U.: Angiotensin II-induced Hypertension: Contribution of Ras GTPase/MAP kinase and cytochrome P-450 metabolites. Hypertension 36:604-609, 2000.

140. Parmentier, J-H., Muthalif, M.M., Nishimoto, A-T. and Malik, K.U.: 20 HETE mediates angiotensin II induced phosphoipase D activation in vascular smooth muscle cells. Hypertension, 37:342-345, 2001

141. Liliom, K., Sun. G., Bunenman, M.M. Virag, T., Nusser, N, Baker, D.L., Wang, D., Fabian, M.J., Brandts, B., Bender, K., Eickels, A., Malik, K. U., Miller, D. D., Desiderio, D., Tigyi, G., and Pott, L. Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cycline function via sphingolipid receptors. Biochemical Journal 355:189-197, 2001

142. Muthalif, M.M., Uddin, M.R., Fatima, S., Parmentier, J-H., Khandekar, Z. and Malik, K.U.: Small GTP binding protein Ras contributes to norepinephrine induced mitogenesis of vascular smooth muscle cells. Prostaglandlins and other lipid mediators. Prostaglandins and Other Lipid Mediators 65:33-43, 2001

143. Muthalif, M.M., Ljuca, F., Roaten, J.B., and Malik, K.U.: Ca2/Calmodulin-dependent protein kinase II and cytosolic phospholipase A2 contribute to mitogenic signaling in myeloblastic leukemia U-937 cells. Journal of Pharmacology and Experimental Therapeutics 298 272-278, 2001

144. Fatima, S., Khandekar, Z., Parmentier, J-H. and Malik, K.U.: Cytosolic phosppholipase A2 activation by the p38 kinase inhibited SB203580 in rabbit nortic smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 298: 331-338, 2001.


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145. Parmentier, J-H., Muthalif, M.M., Saeed, A.E. and Malik, K.U.: Phospholipase D activation by norepinephrine is mediated by 12(s)-,15(s)-, and 20- hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase A2. Journal of Biological Chemistry 276: 15704-15711, 2001.

146. Natarajan, R., Reddy, M. A., Malik, K.U., Fatima, S., and Khan, B. V. Signaling mechanisms of NF-κB mediated activation of inflammatory genes by oxidized fatty acids in vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology 21: 1408-1413, 2001

147. Muthalif, M.M., Hefner, Y., Harper, T., Zhou, H. Parmentier, J-H., Aebersold, R. Gelb, M.H. and Malik, K.U. Functional interaction of calcium/calmodulin-dependent protein kinase II and cytosolic phospholipase (A2). Journal of Biological Chemistry. 276:39653-39660, 2001.

148. Muthalif, M.M., Karzoun, N.A., Benter, I.F., Gaber L., Ljuca, F., Uddin, M.R., Khandekar, Z., Estes, A. and Malik, K.U. Functional significance of activation of calcium/calmodulin dependent kinase II in angiotensin II-induced vascular hyperplasia and hypertension. Hypertension 39: 704-709, 2002.

149. Kalyankrishna, S., Parmentier, J-H and Malik, K.U. Arachidonic acid-derived oxidation products initiate apoptosis in vascular smooth muscle cells. Prostaglandins and other Lipid Mediators. 70: 13-29, 2002.

150. Parmentier, J-H. Ahmed, A., Gandhi, G.K., Saeed A.E., and Malik, K.U. Calcium and protein kinase C (PKC)-related kinase mediates alpha 1A adrenergic receptor-stimulated activation of phospholipase D in rat-1 cells, independent of PKC. Journal of Pharmacology and Experimental Therapeutics 303:1206-1215, 2002.

151. Fatim, S., Yaghini, F. A., Ahmed, A., Khandekar, Z. and Malik, K.U.. CaM kinase IIα mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope. Journal of Cell Science 116: 353-365, 2003.

152. Parmentier, J-H., Smelcer, P., Pavicevic, Z., Basic, E., Idrizovic, A., Estes, A. and Malik, K.U. PKCζ mediates norepinephrine-induced phospholipase D activation and cell proliferation in vascular smooth muscle cells. Hypertension 41:794-800, 2003.

153. Shailaja, K. and Malik, K.U. Norepinephrine induced stimulation of p38 MAPK is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A2 in vascular smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics. 304: 761-772, 2003.

154. Parmentier, J.H., Gandhi, G.K., Wiggins, M.T., Saeed, A.E., Bourgoin, S.G., and Malik, K.U. Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α1Aadrenergic receptor. BMC Cell Biology. 5:4-20, 2004

155. Chan, W.K, Dickerson, A., Ortiz, D., Pimenta, A. F., Moran, C. M., Motil, J., Snyder, S. J., Malik, K., Pant, H. C.,

Shea, T. B. Mitogen-activated protein kinase regulates neurofilament axonal transport. Journal of Cell Science. 117: 4629-4642, 2004.

156. Saeed, A.E., Parmentier, J-H., and Malik, K.U. Activation of α1 adrenergic receptor promotes cell cycle arrest and differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype. BMC Cell Biology5 (1): 47-66, 2004

157. Li, F. and Malik, K.U. Angiotensin II-induced Akt/PKB activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated cytosolic phospholipase A2 in vascular smooth muscle cells. American Journal of Physiology. Heart, Circulation Physiology 288: H2306-H2316, 2005

158. Li, F. and Malik, K.U. Angiotensin II-Induced Akt Activation through the Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells is Mediated by Phospholipid Metabolites Derived by Activation of Phospholipase D. Journal of Pharmacology and Experimental Therapeutics 312: 1043-1054, 2005

159. Yaghini F. A., Zhang C., Parmentier J. H., Estes A., Jafari N., Schaefer S. A., and Malik K. U. Contribution of Arachidonic Acid Metabolite(s) Derived via Cytochrome P450 4A to Angiotensin II-Induced Neointimal Growth. Hypertension 45:1182-1187, 2005.

160. Parmentier, J.H., Lavrentyev, E. N., Falck, J. R. , Capdevilla, J. H., and Malik, K. U. Evaluation of cytochrome p450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. Life Sciences 77:1015-1029, 2005.

161. Li. F., Zhang, C., Susan Schafer, Estes, A. and Malik, K.U. AngII-induced neointimal growth is mediated via cPLA2


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and PLD2 activated Akt in balloon-injuredrat carotid arteries. American Journal of Physiology American Journal of Physiology, Heart Circulation Physiology 289: H2592-2601, 2005.

162. Tunctan, B., Yaghini, F.A., Estes, A., and Malik, K.U. nhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats. Nitric Oxide: Biology and Chemistry.14: 51-57, 2006.

163. Parmentier, J.H. Pavicevic, Z. and Malik, K. U. ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy. American Journal of Physiology Heart Circ Physiol. 2006 290:H4654. 2006.

164. Parmentier, J-H., Zhang, C., Estes, A. and Malik, K.U. Essential role of PKCζ in normal and angiotensin II-accelerated neointimal growth after balloon angioplasty. American Journal of Physiology. 291: H1602-1613, 2006.

165. Yaghini, A., Li, F. and Malik, K.U. Expression and mechanism of Syk activation by angiotensin II and its implication in protein synthesis in rat vascular smooth muscle cells. Journal of Biological Chemistry 282:16878-16890, 2007.

166. Lavrentyev, E. N., Estes, A. M. and Malik, K. U. Mechanism of high glucose induced AngII production in rat vascular smooth muscle cells. Circulation Research 101: 455-464, 2007.

167. Pavicevic, Z., Leslie, C. C. and Malik, K. U. cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. Journal of Lipid Research, 49: 724-737, 2007.

168. Lavrentyev, E.N. and Malik, K.U. High Glucose-induced Nox1-derived superoxides down-regulate PKCβII proteins levels that subsequently decreases ACE2 expression and Ang (1-7) formation in rat VSMC. American Journal of

Physiology. American Journal of Physiology 296:H106-H18, 2008. PMCID: PMC2637775 169. Tunctan, B., Korkmaz, B., Buharalioglu, C. K., Firat, S. S, Anjaiah, S., Falck, J., Roman, R. J. and Malik, K. U. A 20-

hydroxyeicosatetraenoic acid agonist, N- [20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock, 30:329-35, 2008. PMCID:PMC2615390

170. Tunctan, B., Yaghini, F. A., Estes, A., and Malik, K.U. Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production. Archiv for Pharmacological Research. 31(7):856-65. 2008. PMCID: PMC2684946

171. Mugabe, B. E., Yaghini, F. A., Song, C., Buharalioglu, C. K., Waters, C. M. and Malik, K. U. Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38-MAPK activated c-Src through spleen tyrosine kinase and EGFR transactivation. Journal of Pharmacology and Experimental Therapeutics. 332: 116-124, 2010. PMCID: PMC2802473

172. Cuez, T., Korkmaz, B., Buharalioglu, C. K., Sahan-Firat, S., Falck, J., Malik, K. U. and Tunctan, B. A synthetic analogue of 20-HETE, 5, 14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasdilator prostanoid production in rats. Basic Clinical Pharmacology and Toxicology. 106:378-388, 2010. PMCID:PMC2882512

173. Yaghini, F. A., Song, C. Y., Lavrentyev, E. N., Ghafoor, H. U. B., Fang, X. R., Estes, A. M., Campbell, W. B., and Malik, K. U. Angiotensin II-induced vascular smooth muscle cell migration and growth are mediated by cytochrome P450 1B1 dependent superoxide generation. Hypertension. 55: 1461-1467, 2010.PMCID: PMC2916227

174. Tunctan, B., Korkmaz, B., Cuez, T., Kemal Buharalioglu, C., Sahan-Firat, S., Falk, J., Malik, K. U. Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats. Basic Clinical Pharmacology and Toxicology.107: 877-882, 2010. PMCID: PMC3128812

175. Jennings, B. L., Sahan-Firat, S., Estes, A. M., Das, K., Farjana, N., Fang, X. R., Gonzalez, F. J., and Malik, K. U. Cytochrome p450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. Hypertension. 56: 667-674, 2010. PMCID: PMC2946077

176. Sahan-Firat, S., Jennings, B. L., Yaghini, C. Y., Estes, A. M., Fang, X. R., Farjana, N., Khan, A. H., and Malik, K.U. 2,3´,4,5´- Tetramethoxystilbene prevents deoxycorticosterone-Salt-induced hypertension: Contribution of


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cytochrome P4501B1. American Journal of Physiology, Heart and Circulation Physiology. 299: H1891-H1901, 2010. PMCID:PMC3006285

177. Zhu, L., Maruvada, R., Sapirstein A., Malik, K. U., Peters-Golden and Kim, K.S. Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier. Infection and Immunity. 78: 4302-4310, 2010. PMC2950368

178. Buharalioglu, C. K., Korkmaz, B., Cuez, T., Sahan-Firat, S., Ayşe Nihal Sari, A. N., Malik, K.U., Tunctan, B. Piroxicam Reverses Endotoxin-Induced Hypotension In Rats: Contribution of Vasoactive Eicosanoids and Nitric Oxide. Basic and Clinical Pharmacology and Toxicology. Basic Clinical Pharmacology and Toxicology. 109:186-194, 2011. PMCID:PMC3158973

179. Buharalioglu, C. K., Song, C. Y., Fariborz A. Yaghini, Hafiz U.B. Ghafoor, Mustafa Motiwala, Tusita Adris, Anne M. Estes, and Kafait U. Malik. Angiotensin II-induced Process of Angiogenesis is Mediated by Spleen Tyrosine Kinase via VEGF Receptor-1 Phosphorylation. American Journal of Physiology, Heart Circ Physiol. H1043-1055, 2011. PMCID:PMC3289420

180. Weber, K. T., Bhattaccharya, S. K., Newman, K. P., Soberman, J. E., Ramanathan, K. B., McGee, J. E. Malik, K. U., Hicherson, W. L. Stressor states and the cation crossroads. Journal of American College of Nutrition. 29: 563-574, 2010.

181. Jennings, B. L., Anderson, L. J., Estes, A. M. Yaghini, F. A., Fang, X. R., J., Gonzalez, F. J., Campbell, W. B. and Malik, K. U. Cytochrome 1B1 contributes renal dysfunction and damage caused by angiotensin II in mice. Hypertension. 59:348-354, 2011. PMCID:PMC3268066

182. Jennings, B. L., Anderson, L. J., Estes, A. M., Fang, X. R., Song, C. Y., Campbell, W. B., and Malik, K. U. Involvement of cytochrome P450 1B1 to renal dysfunction, injury, and inflammation associated with angiotensin II-induced

hypertension in rats. American Journal of Physiology. 302: F408-420, 2012. PMCID:PMC3289420 183. Tunctan B, Sari AN, Kacan M, Unsal D, Buharalioglu CK, Sahan-Firat S, Korkmaz B, Falck JR, Malik KU. NS-398

reverses hypotension in endotoxemic rats: Contribution of eicosanoids, NO, and peroxynitrite. Prostaglandins Other Lipid Mediators. 2012 Sep 5. doi:pii: S1098-8823(12)00117-7. [PubMed-in Process]

PMID: 22975359 184. Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Schunck WH, Falck JR,

Malik KU. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. Antiinflammatory Antiallergy Agents

Medicinal Chemistry. 11:121-50, 2012. PMID: 23013331 185. Jennings BL, Estes AM, Anderson LJ, Fang XR, Yaghini FA, Fan Z, Gonzalez FJ, Campbell WB, Malik KU. Cytochrome

P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice. Hypertension. 60:1510-1516, 2012. PMCID:PMC 3499668

186. Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU. 5,14-HEDGE, a 20- HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation. Prostaglandins Other Lipid Mediators. 102-103: 31-41, 2013. [PubMed in Process]. PMID:23454652

187. Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU. Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. Nitric Oxide 33: 18-41, 2013.

188. Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka

AV, Tigyi G, Benyó Z. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. 28:880-900, 2014.

189. Jennings BL, Montanez DE, May ME Jr, Estes AM, Fang XR, Yaghini FA, Kanu A, Malik KU. Cytochrome P450 1B1


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contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats. Cardiovasc. Drugs Ther. 28:145-14612014.

190. Jennings BL, George LW, Pingili AK, Khan NS, Estes AM, Fang XR, Gonzalez FJ, Malik KU. Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice. Hypertension. 64: 134-140, 2014.

191. Sari AN, Korkmaz B, Serin MS, Kacan M, Unsal D, Buharalioglu CK, Sahan Firat S, Manthati VL, Falck JR, Malik KU, Tunctan B. Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock. Inflamm Res. 63:741-56, 2014.

B. Chapters in Monographs and/or Books

1. Terragno, N.A., Malik, K.U., Nasjletti, A., Terragno, A. and McGiff, J.C.: Renal Prostaglandins. In: Advances in Prostaglandin and Thromboxane Research, edited by B. Samuelsson and R. Paoletti, Raven Press, New York, pp. 501-571, 1976.

2. Malik, K.U. and McGiff, J.C.: Chapter 5: Cardiovascular actions of prostaglandins. In: Prostaglandins - Progress in Research. Editor: S.M.M. Karim, M.T.P. Press Ltd., Lancaster, U.K., pp. 103-200, 1976.

3. McGiff, J.C. and Malik, K.U.: Chapter 6: Renal prostaglandins. In: Prostaglandins - Progress in Research. Editor: S.M.M. Karim, M.T.P. Press Ltd., Lancaster, U.K., pp. 201-245, 1976.

4. Nasjletti, A., Malik, K.U. and Kauker, M.: Prostaglandins and renal blood flow. In: Annual Research Reviews (Eden Press, Montreal, Canada), edited by J.B. Lee, Vol. 1, pp. 84-91, 1978.

5. Wong, P. Y-K, Sun, F.F., Malik, K.U., Cagen, L. and McGiff, J.C.: Metabolism of prostacyclin. In: Prostacyclin, edited by J.R. Vane and S. Bergstrom, Raven Press, New York, pp. 133-145, 1979.

6. Sun, F.F., Taylor, B.M., McGuire, J.C., Wong, P. Y-K, Malik, K.U. and McGiff, J.C.: Metabolic disposition of prostacyclin, edited by J.R. Vane and S. Bergstrom, Raven Press, New York, pp. 119-131, 1979.

7. Malik, K.U. and Nasjletti, A.: Effect of bradykinin at the vascular neuroeffector junction. In vascular neuroeffector mechanisms. Chapter 8 - Endogenous autocoids in blood vessel function. Edited by Bevan et al. Raven Press, New York, pp. 76-82, 1980.

8. Khan, M.T. and Malik, K.U.: Sympathetic nerve stimulation of the isolated rat heart: Release of a prostaglandin-like substance and the inhibitory effect of prostacyclin on the output of [3H]-norepinephrine. In: Advances in Prostaglandin and Thromboxane Research, Vol. 8. Edited by B. Samuelsson, P.W. Ramwell and R. Paoletti. Raven Press, New York, pp. 1241-1243, 1980.

9. Malik, K.U. and Nasjletti, A.: Modulation by prostaglandins of vascular reactivity to adrenergic stimuli. In atherosclerosis V. Edited by A.M. Gotto, Jr., Louis C. Smith and Barbar Allen. Springer Verlag, New York, Inc., pp. 766-771, 1980.

10. Nasjletti, A. and Malik, K.U.: Interrelationship of the renal kallikrein-kinin and prostaglandin systems. In: Enzymatic release of vasoactive peptides. Ed. F. Gross and G. Vogel, Raven Press, New York, pp. 325-336, 1980

11. Nasjletti, A. and Malik, K.U.: The renal kallikrein-kinin and prostaglandin systems interaction. Annual Reviews of Physiology, 43:597-609, 1981.

12. Nasjletti, A. and Malik, K.U.: Interaction of kinins and renal prostaglandins. In: Frontiers in Hypertension, Edited by J.H. Laragh, F.R. Buhler and D.W. Seldin, Springer Verlag, New York, pp. 119-121, 1981.

13. Malik, K.U. and Nasjletti, A.: Kinins-adrenergic nervous system interaction in the kidney: Relationship to prostaglandins. Trends in Autonomic Pharmacology, Vol. 2, Edited by S. Kalsner, Urban and Schwarzenburg, Baltimore - Munich, pp. 207-215, 1982.

14. Cooper, C.L. and Malik, K.U.: Mechanism of action of vasoactive substances on prostaglandin synthesis in the kidney. In: Advances in Prostaglandin, Thromboxane and Leukotriene Research, Raven Press, New York, Vol. 15, Chapter 116, pp. 437-439, 1985.


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15. Malik, K.U. and Sehic, E.: Prostaglandins and the release of the adrenergic transmitter. In: Presynaptic

receptors and the question of autoregulation of neurotransmitter release.S. Kalsner and T.C. Westfall (Eds). Annals of New York Academy of Sciences, Vol. 604, pp. 222-236, 1990.

16. Malik, K.U.: Contribution of eicosanoids in the heart. In: Contemporary Endocrinology: Hormones and the Heart in Health and Disease. Edited by L. Share, Human Press, Inc., Totowa, NJ, pp. 195-218, 1999.

17. Fatima, S., Yaghini, F. A., and Malik, K.U. Cytosolic phospholipase A2 translocation to the nuclear envelope by neurohumoral agents in vascular endothelial and smooth muscle cells. Pp 47- 61, 2004. In: Biochemistry of Lipids in Vascular Function, Edited by Mario Alberghina, Research Singpost ,Trivandrum, Kerala, India.

18. Malik, K. U., Jennings, B. L., Yaghini, F. A., Sahan-Firat S., Song, C. Y., Estes, A. M., and Fang, X. R. Contribution of cytochrome P450 1B1 to hypetension and associated pathophysiology: A novel target for antihypertensive agents. Prostaglndins Other Lipid Mediators. 2011 Dec 20. [Epub ahead of print].PMC3339277

C. Abstracts

1. Malik, K.U. and Hukovic, S.: Permeability of histamine across the intestine under the influence of stimulation of autonomic nerves in vitro. NaunynSchmiedeberg. Arch. Pharmak. Exp. Path. 257:42, 1967.

2. Malik, K.U. and Muscholl, E.: Die Wirkung Sympathomimetischer Amine auf den Sympathischen Reizerfolg am perfundierten H. Mesenterica-Praparat der Ratte. Naunyn-Schmiedebergs Arch. Pharmak. Exp. Path. 257:311, 1967.

3. Malik, K.U. and Ling, G.M.: Effect of dimethylphenylpiperazinium iodide on the pressor response of mesenteric arteries to sympathetic nerve stimulation. Canadian Federation of Biological Societies 12: 1969.

4. Malik, K.U. and Ling, G.M.: Effect of acetylcholine on the response of mesenteric arteries of rat to sympathetic nerve stimulation. Abstracts of the 4th International Congress on Pharmacology, pp. 364, 1969.

5. Malik, K.U. and McGiff, J.C.: Effect of choline and tetraethylammonium on adrenergic transmission in perfused mesenteric arteries of rat. Fed. Proc. 30:655, 1971.

6. Terragno, N.A., Crowshaw, K., Malik, K.U., Lonigro, A. and McGiff, J.C.: Loss of adrenergic-induced renal vasoconstriction and the selective release of a prostaglandin E-like substance into canine renal venous blood. Fed. Proc. 30:486, 1971.

7. Lonigro, A.J., Terragno, N.A., Malik, K.U. and McGiff, J.C.: Modification of the renal vasodilator action of bradykinin by an inhibitor of prostaglandin synthesis. Fed. Proc. 31:545, 1972.

8. Malik, K.U. and McGiff, J.C.: Modification by hexamethonium of adrenergic transmission in rat mesenteric arteries. Fed. Proc. 31:565, 1972.

9. Malik, K.U. and McGiff, J.C.: Modulation by carbohydrates and their metabolites of adrenergic transmission in rat mesenteric arteries. Fed. Proc. 32:706, 1973.

10. Malik, K.U. and McGiff, J.C.: Modulation by prostaglandins (PG) of adrenergic trans-mission in the isolated kidney of rat and rabbit. Fed. Proc. 33:575, 1974.

11. Malik, K.U., Nasjletti, A. and McGiff, J.C.: Facilitation of adrenergic transmission by locally generated angiotensin II (Ang II) in rat mesenteric arteries. Pharmacologist 16:289, 1974.

12. Malik, K.U. and McGiff, J.C.: Modulation by prostaglandin E1 of adrenergic transmission in isolated perfused rabbit and rat mesenteric arteries. Fed. Proc. 34:763, 1975.

13. Malik, K.U. and McGiff, J.C.: Modification by anoxia of adrenergic transmission in isolated perfused rat mesenteric arteries. Abstracts of the 8th International Congress of Pharmacology, Finland, 1975.

14. Malik, K.U. and McGiff, J.C.: Modulation of adrenergic transmission by prostaglandins (PG) in the isolated splenic vasculature of rabbit and rat. Fed. Proc. 35: 297, 1976.

15. Hamamdzic, M. and Malik, K.U.: Effect of prostaglandins (PGs) on adrenergic responses in the isolated perfused rat pancreas. Pharmacologist 18:115, 1976.


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16. Malik, K.U. and Nasjletti, A.: Inhibitory effect of bradykinin on vascular responses to sympathetic nerve stimulation in the isolated perfused rabbit kidney. Proc. 36:3547, 1977.

17. Malik, K.U. and Nasjletti, A.: Facilitatory effect of bradykinin on adrenergic transmission in the isolated perfused rat kidney. Pharmacologist 19:158, 1977.

18. Khan, M.T. and Malik, K.U.: Inhibition by adenosine and adenine nucleotides on the efflux of 3H-norepinephrine from the isolated rat heart evoked by potassium. Fed. Proc. 37:736, 1978.

19. Wong, P. Y-K, Malik, K.U., Sun, F.F. and McGiff, J.C.: Metabolism of prostacyclin (PgI2) in tissues of rat and rabbit. Fed. Proc. 37:1318, 1978.

20. Malik, K.U., McGiff, J.C. and Wong, P. Y-K: A novel prostaglandin as the major product of arachidonic acid

metabolism in rabbit and rat spleen. Fed. Proc. 37:1319, 1978. 21. Khan, M.T. and Malik, K.U.: Inhibitory effect of prostaglandins (PG)I2 and E2 on the release of 3H-norepinephrine

(3H-NE) evoked by potassium or electrical stimulation of the isolated rat heart. Pharmacologist 20:185, 1978. 22. Hidaka, T., Wong, P. Y-K and Malik, K.U.: Metabolism of arachidonic acid on passage through the isolated rabbit

spleen. Pharmacologist 20:234, 1978. 23. Malik, K.U.: Inhibitory effect of prostaglandin (PGE2) on the release of norepinephrine evoked by renal nerve

stimulation in the rat kidney. Abstracts - 7th International Congress of Pharmacology, pp. 807, 1978. 24. Malik, K.U. and Nasjletti, A.: Effect of bradykinin at vascular neuroeffector junction. Abstracts - IIIrd International

Symposium on Vascular Neuroeffector Mechanisms, pp. 33, 1979. 25. Hidaka, T. and Malik, K.U.: Prostaglandin E2 is the major product of arachidonic acid released by sympathetic

nerve stimulation (SNS), administered norepinephrine (NE) and bradykinin (BK) from isolated perfused rabbit spleen. Fed. Proc. 38, 751, 1979.

26. Wong, P. Y-K, Malik, K.U., McGiff, J.C. and Sun, F.F.: Renal and hepatic clearance of prostacyclin (PGI2) in the rabbit. Fed. Proc. 38:752, 1979.

27. Hidaka, T., Wong, P.Y-K and Malik, K.U.: Prostaglandin E2 is the major product formed from arachidonic acid on passage through the isolated perfused spleen of rabbit. Abstracts - IV International Prostaglandin Conference, pp. 48, 1979.

28. Khan, M.T. and Malik, K.U.: Sympathetic nerve stimulation of the isolated rat heart: Release of a prostaglandin (PG)I2-like substance and the inhibitory effect of PGI2 on the output of [3H]-Norepinephrine. Abstracts - IV International Prostaglandin Conference, pp. 60, 1979.

29. Sun, F.F., Malik, K.U., McGiff, J.C. and Wong, P. Y-K: Evidence for a one carbon degradation pathway in the metabolism of PGI2 by rabbit kidney. IV International Prostaglandin Conference, pp. 112, 1979.

30. Wong, P. Y-K, Malik, K.U., Sun, F.F., Lee, W.H. and McGiff, J.C.: Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent inhibitor of platelet aggregation. Abstracts - IV International Prostaglandin Conference, pp. 127, 1979.

31. Malik, K.U.: Differential effect of α-adrenergic blocking agents on the vasoconstrictor responses to periarterial nerve stimulation and injected norepinephrine in the isolated rat kidney. Fed. Proc. 39:1004, 1980.

32. Lanier, S. Duzic, E. and Malik, K.U.: Increases in the electrically evoked release of 3H-norepinephrine from the isolated rat heart during infusion of angiotensin II: Effect of prostaglandin synthesis inhibition. Fed. Proc. 39:368, 1980.

33. Susic, S., Nasjletti, A. and Malik, K.U.: Inhibition by bradykinin of the vasoconstrictor responses to sympathetic nerve stimulation and norepinephrine in the canine kidney: Relationship to prostaglandin synthesis. Fed. Proc. 39:997, 1980.


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34. Susic, H., Nasjletti, A. and Malik, K.U.: Inhibition by bradykinin of the vascular effects of angiotensin II in the canine kidney. Relation to prostaglandins. Abstracts VII Meeting of the International Society of Hypertension 129, 1980.

35. Lee, T.S., Duzic, E. and Malik, K.U.: Facilitation by bradykinin of adrenergic transmission in the isolated rat heart: Effect of prostaglandin synthesis inhibition. Pharmacologist 22:218, 1980.

36. Lanier, S.M. and Malik, K.U. Mechanism by which indomethacin (IND) and angiotensin II (AII) facilitate adrenergic transmission in the isolated rat heart. Fed. Proc. 40:243, 1981.

37. Shaffer, J.E., Cagen, L.M. and Malik, K.U.: Effect of acetaminophen and indomethacin on arachidonic acid-induced coronary vasodilation and prostaglandin release in the isolated rat heart. Fed. Proc. 40:706, 1981.

38. Morgan, R.L. and Malik, K.U.: Mechanism of captopril-induced renal vasodilation during saralasin infused in anesthetized dogs. Fed. Pro. 40:436, 1981.

39. Powers, C.A., Malik, K.U. and Nasjletti, A.: Kinin-forming activity in the anterior pituitary of the rat. Fed. Proc. 40:401, 1981.

40. Böke, T. and Malik, K.U.: Locally generated angiotensin augments the release of the adrenergic transmitter and the vasoconstrictor response elicited by sympathetic nerve stimulation in the rat kidney. Red. Proc. 41:1342, 1982.

41. Lanier, S.M., Shaffer, T.E. and Malik, K.U.: Effect of intracoronary angiotensin II (AII) infusion on adrenergic

transmission in the heart of anesthetized dog. Fed. Proc. 41:1654, 1982. 42. Inokuchi, K. and Malik, K.U.: Prostaglandins attenuate adrenergically-induced vasoconstriction in the kidney of

the anesthetized rat. Fed. Proc. 41:1722, 1982. 43. Shaffer, T.E. and Malik, K.U.: Activation of cardiac β-adrenoceptors enhances the output of prostaglandins (PG) in

the rabbit heart. Fed. Proc. 41-1766, 1982. 44. Cooper, C., Shaffer, T.E. and Malik, K.U.: Effect of Ca++ deprivation of prostaglandin (PG) E2 synthesis and on the

vascular response to norepineprhine (NE) angiotensin II (AII) and bradykinin. Pharmacologist 24:113, 1982. 45. Lanier, S.M. and Malik, K.U.: Attenuation by prostaglandins (PG) prejunctional facilitatory effect of angiotensin II

(AII) at the adrenergic neuroeffector junction in the isolated rat heart. Pharmacologist 24:113, 1982. 46. Inokuchi, K. and Malik, K.U.: Inhibition by bradykinin of adrenergically-induced vasoconstriction in the kidney of

anesthetized rats. Pharmacologist 24:195, 1982. 47. Cooper, C.L. and Malik, K.U.: Prostaglandin synthesis elicited by vasoactive hormones in the isolated rat kidney.

Fed. Proc. 42:639, 1983. 48. Malik, K.U. and Cooper, C.L.: Effect of dexamethasone, corticosterone and mepacrine on prostaglandin synthesis

elicited by vasoactive hormones in the isolated rat kidney. Fed. Proc. 47:640, 1983. 49. Gregory, R.E. and Malik, K.U.: Stimulation of prostaglandin synthesis in the isolated rabbit heart by isoproterenol

but not by other agents that increase levels of cAMP. Fed. Proc. 47:640, 1983. 50. Lanier, S.M. and Malik, K.U.: Facilitation of adrenergic transmission by intracoronary angiotensin II (AII) in heart

of anesthetized dogs: Effect of prostaglandin (PG) synthesis inhibition. Fed. Proc. 47:897, 1983. 51. Böke, T. and Malik, K.U.: Modulation by α1-adrenoceptor agents of the vasoconstrictor response (VR) and

neurotransmitter release in the rat kidney. Fed. Proc. 47:1364, 1983. 52. Lanier, S.M. and Malik, K.U.: Modulation by prostaglandins of adrenergic transmission in the heart of

anesthetized dogs. Pharmacologist 25:143, 1983. 53. Cooper, C.L. and Malik, K.U.: Differential Ca2+ requirements for prostaglandin (PG) synthesis and renal

vasoconstriction (RV) elicited by α1-adrenergic receptor agonists in the rat kidney. Pharmacologist 25:143, 1983. 54. Clark, K., Cooper, C.L. and Malik, K.U.: Prostaglandin (PG) synthesis elicited by norepinephrine (NE) is linked to α-

adrenoceptor activation in the isolated rat kidney. Pharmacologist 25:143, 1983. 55. Iwatsuki, K., Homma, T. and Malik, K.U.: Contribution of prostaglandins (PGs) to the action of dopamine (DA) on

pancreatic circulation in anesthetized dogs. Fed. Proc. 43:757, 1984.


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56. Weis, M. and Malik, K.U.: Effects of altered extracellular Ca++ concentration and of calmodulin (C) inhibitors on prostaglandin synthesis elicited by isoproterenol (ISOP) in the isolated rabbit heart. St. Louis, Missouri. Fed. Proc. 43:932, 1984.

57. Cooper, C.L. and Malik, K.U.: Effect of calmodulin inhibitors on prostaglandin (PG) synthesis and renal vasoconstriction (RV) elicited by vasoactive substances in the isolated rat kidney. Fed. Proc. 43:1039, 1984.

58. Cooper, C.L. and Malik, K.U.: Differential effect of cAMP on renal vasoconstriction (RV) and prostaglandin (PG) output elicited by vasoactive substances in the isolated rat kidney. Pharmacologist 26:155, 1984.

59. Weis, M. and Malik, K.U.: Isoproterenol induced prostaglandin (PG) synthesis in the isolated rabbit heart. Effect of Ca++ depletion and extracellular and intracellular Ca2+ antagonists. Pharmacologist 26:155, 1984.

60. Weis, M. and Malik, K.U.: Enhanced metabolism of arachidonic acid to prostaglandins in the absence of extracellular (Ca++) in the isolated rabbit heart. Fed. Proc. 44:902, 1985.

61. Cooper, C.L. and Malik, K.U.: Mechanism of action of bradykinin (BK) on renal prostaglandin (PG) synthesis: Comparison with other vasoactive substances. Fed. Proc. 44:1470, 1985.

62. Weis, M.T. and Malik, K.U.: The influence of Ca2+ on the acylation of fatty acids in the isolated perfused rabbit heart. Pharmacologist 27:176, 1985.

63. Kuroda, T. and Malik, K.U.: Effect of inhibitors of oxidative phosphorylation on vasoconstrictor stimuli in isolated rat mesenteric arteries. Fed. Proc. 45:670, 1986.

64. Iijima, F., Chiba, S. and Malik, K.U.: Contribution of vasopressin in dexamethasone-induced hypertension in rats. Fed. Proc. 45:754, 1986.

65. Cooper, C.L. and Malik, K.U.: Effect of phospholipase and glycerolipase inhibitors on renal prostaglandin synthesis elicited by vasoactive substances: Evidence for activation of a distinct lipase by bradykinin. Fed. Proc. 45:924, 1986.

66. Williams, T.L., Jr. and Malik, K.U.: Isoproterenol, but not glucagon or forskolin, stimulates lipolysis in the isolated

rabbit heart: Effect of prostaglandins. Fed. Proc. 45:1039, 1986. 67. Weis, M.T. and Malik, K.U.: Regulation by calcium of cardiac arachidonate metabolism. Fed. Proc. 45:924, 1986. 68. Mohy El-Din, M.M. and Malik, K.U.: Mechanism of norepinephrine release elicited by renal nerve stimulation,

veratridine and potassium chloride in the rat-isolated kidney. Soc. of Neuroscience Abstracts 12:807, 1987. 69. Mohy El-Din, M.M. and Malik, K.U.: Modification of hormonally-induced prostaglandin synthesis and renal

vasoconstriction by protein kinase C activation in isolated rat kidney. Fed. Proc. 46:551, 1987. 70. Weis, M.T. and Malik, K.U.: Uptake and distribution of [3H] phosphatidylcholine in tissue lipids in isolated

perfused rabbit heart: Influence of hormones on its metabolism. Fed. Proc. 46:873, 1987. 71. Williams Jr., J.L., Weis, M.T. and Malik, K.U.: Hormone stimulated lipolysis in perfused rabbit heart: Contribution

of Ca2+. Fed. Proc. 46:1257, 1987. 72. Palazzo, A., Weis, M.T., Williams, J.L. and Malik, K.U.: Selective incorporation of [3H]triolein into triglyceride pool

and its metabolism in response to vasopressin in isolated rabbit heart. Fed. Proc. 46:1258, 1987. 73. Malik, K.U. and Mohy El-Din, M.M.: Selective incorporation of 3H-labeled glycerolipids into tissue lipids in the

isolated rabbit kidney. Fed. Proc. 46:1283, 1987. 74. Qureshi, Z. and Malik, K.U.: Veratridine (Vt)-induced cardiac prostaglandin (PG) synthesis by a tetrodotoxin (TTx)

resistant mechanism. Pharmacologist 29:213, 1987. 75. Jaiswal, N. and Malik, K.U.: Stimulation of cardiac prostaglandin (PG) synthesis by cholinergic stimuli is linked to

activation of M2 subtype of muscarinic receptors (MR). Pharmacologist 29:213, 1987. 76. Mohy El-Din, M.M. and Malik, K.U.: Differential effect of ω−Conotoxin on release of the adrenergic transmitter

and the vasoconstrictor response to norepinephrine in the isolated rat kidney. Fed. Proc. 2:A311, 1988. 77. Williams, Jr., J.L. and Malik, K.U.: Inhibition by cAMP of adrenergically-induced prostaglandin (PG) synthesis in the

isolated rabbit heart. Fed. Proc. 2:A382, 1988.


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78. Jaiswal, N. and Malik, K.U.: Contribution of M2α and M2β muscarinic receptors (MR) on the action of the cholinergic stimuli on cardiac prostaglandin (PG) synthesis. Fed. Proc. 2:A789, 1988.

79. Weis, M., Palazzo, A.T., and Malik, K.U.: Hormonally induced lipolysis in the isolated rabbit heart labeled with [3H]Triolein. Fed. Proc. 2:A1309, 1988.

80. Adeagbo, A.S.O. and Malik, K.U.: Preferential attenuation of hormonally-induced vascular tone by prostaglandin I2 (PGI2) in isolated perfused rat mesenteric arteries. Fed. Proc. 2:A1571, 1988.

81. Sehic, E. and Malik, K.U.: Effect of protein kinase C (PKC) inhibitors on adrenergic neurotransmitter release in the isolated rat kidney. Fed. Proc. 2:A1733, 1988.

82. Malik, K.U., Weis, M.T., and Jaiswal, N.: Mechanism of action of adrenergic and cholinergic stimuli on cardiac prostaglandin synthesis. Taipei Conference on Prostaglandin and Leukotriene Research Abstracts 124, 1988.

83. Mistry, M. and Malik, K.U.: Triphasic response to arachidonic acid (AA) on blood pressure in conscious rats. Pharmacologist 30:A206, 1988.

84. Adeagbo, A.S.O. and Malik, K.U.: Differential effect of cytochrome P450 inhibitors on arachidonic acid (AA) and acetylcholine (ACh) induced endothelium-dependent relaxation in isolated perfused rat mesenteric arteries (MAS). Pharmacologist 30:A209, 1988.

85. Sehic, E. and Malik, K.U.: Contribution of adrenergic and purinergic transmitters to prostaglandin (PG) synthesis elicited by renal nerve stimulation (RNS) in the isolated rat kidney. Fed. Proc. 3:A608, 1989.

86. Oellerich, W.F. and Malik, K.U.: Arginine vasopressin (AVP) inhibits adrenergic transmitter release in the rat kidney. Fed. Proc. 3:A743, 1989.

87. Williams, Jr., J.L. and Malik, K.U.: Forskolin stimulates prostaglandin (PG) synthesis in rabbit heart by a mechanism independent of cAMP and dependent on extra- and intracellular calcium. Fed. Proc. 3:A743, 1989.

88. Schwartz, D.D. and Malik, K.U.: Renal vasoconstriction elicited by periarterial nerve stimulation is primarily due to a purinergic component in the rat. Fed. Proc. 3:A744, 1989.

89. Jaiswal, N. and Malik, K.U.: Muscarinic stimulation of vascular prostaglandin (PG) synthesis: Contribution of M2α and M2β muscarinic receptors (MR). Fed. Proc. 3:A889, 1989.

90. Adeagbo, A.S.O. and Malik, K.U.: Mechanism of prostacyclin induced endothelium dependent biphasic actions in the rat isolated perfused mesenteric arteries (MAs). Fed. Proc., 3:A1176, 1989.

91. Nebigil, C., Jaiswal, N., and Malik, K.U.: Prostaglandin (PG) synthesis elicited by adrenergic stimuli in rabbit aorta

is mediated via α1 and α2 adrenergic receptors (AR). Fed. Proc. 3:1201, 1989. 92. Hong, K. and Malik, K.U.: Effect of adrenergic and cholinergic stimuli on prostaglandin synthesis in cultured

myoctyes from newborn rat. Fed. Proc. 4:A294, 1990. 93. Nadel, G.L., Malik, K.U. and Lew, D.B.: Prostaglandin (PG) E2 synthesis elicited by adrenergic stimuli in guinea-pig

trachea (GPT) is mediated primarily by β2 adrenergic receptors. Fed. Proc. 4:A715, 1990. 94. Sehic, E., Cano, C. and Malik, K.U.: Prostaglandin synthesis in aortic vascular smooth muscle cells (VSMC) is

mediated via A, adenosine receptors. Fed. Proc. A1008, 1990. 95. Cano, C. and Malik, K.U.: Contribution of A1 and A2 receptors to the action of adenosine on prostacyclin synthesis

and mechanical function in the isolated rabbit heart. Fed. Proc. 4:A1010, 1990. 96. Jaiswal, R.K., Jaiswal, N. and Malik, K.U.: Muscarinic receptors in cultured endothelial and vascular smooth muscle

cells. Fed. Proc. 4:A1124, 1990. 97. Malik, K.U. and Jaiswal, N.: Pharmacological characterization of vascular muscarinic receptor(s) mediating

relaxation and contraction in rabbit aorta. Fed. Proc. 4:A1124, 1990. 98. Nebigil, C. and Malik, K.U.: Prostaglandin synthesis elicited by adrenergic stimuli in aortic vascular smooth muscle

cells (VSMC) is mediated via alpha-1 and alpha-2B adrenergic receptors. Fed. Proc. 4:A1203, 1990. 99. Schwartz, D.D. and Malik, K.U.: Phenylephrine evoked release of norepinephrine (NE) and cAMP accumulation in

superfused cultured superior cervical ganglion cells from rats. Fed. Proc. 4:A1203, 1990.


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100. Nebigil, C. and Malik, K.U.: Characterization and possible signal transduction mechanism of adrenergic receptor-mediated stimulation of prostaglandin (PG) synthesis in vascular smooth muscle cells (VSMC) of rabbit aorta. Abstracts - 7th International Conference on Prostaglandins and Related Compounds, pp. 59, 1990.

101. Lew, D.B., Nebigil, C., and Malik, K.U.: Prostaglandin (PG) synthesis elicited by adrenergic stimuli in bovine tracheal smooth muscle cells (TSMC) is mediated predominantly via beta-1adrenergic receptors. Abstracts - 7th International Conference on Prostaglandins and Related Compounds, pp. 315, 1990.

102. Nebigil, C. and Malik, K.U.: Characterization of subtypes of alpha-1 adrenergic receptors and associated signal transduction mechanisms involved in vascular smooth muscle contraction and prostaglandin synthesis in the rabbit aorta. European Journal of Pharmacology 183:1602, 1990.

103. Nebigil, C. and Malik, K.U.: Mechanism of alpha-2B adrenergic receptor stimulated prostaglandin (PG) synthesis in rabbit aortic vascular smooth muscle cells (VSMC). Pharmacologist 32:121, 1990.

104. Sehic, E., Ryan, Y., and Malik, K.U.: Vasoconstrictor responses of isolated rat kidney to renal periarterial nerve stimulation and vasoactive agents in the presence ofα β methylene ATP. FASEB J. 5:A414, 1991.

105. Malik, K.U. and Schwartz, D.D.: Alpha-2 adrenergic receptor-mediated inhibition of neurotransmitter release in cultured superior cervical ganglion cells (SCGC) is no coupled to cAMP. FASEB J. 5:A855, 1991

106. Oellerich, W.F. and Malik, K.U.: Pre- and postjunctional actions of neuropeptide Y (NPY) in the isolated perfused rat kidney. FASEB J. 5:A864, 1991.

107. Schwartz, D.D. and Malik, K.U.: Prejunctional alpha-2D adrenergic receptor activation modulates norepinephrine release in the isolated perfused rat kidney. FASEB J. 5:A1434, 1991

108. Cano, C., Qureshi, Z, and Malik, K.U.: Contribution of adenosine to isoproterenol-stimulated prostacyclin production and mechanical function in the isolated rabbit heart. FASEB J. 5:A1573, 1991.

109. Lew, D.B., Nebigil, C., Ferguson, S.F., and Malik, K.U.: Role of cAMP in β hexosaminidase-induced mitogenesis in bovine tracheal myocytes: A link between mannose receptor and adenylate cyclase. FASEB J. 5:A1591, 1991.

110. Nebigil, C. and Malik, K.U.: Pertussis toxin (PTX) inhibits alpha-1A and alpha-2B- adrenergic receptor (AR) stimulated prostaglandin (PG) synthesis and increases in cytosolic calcium in rabbit aortic smooth muscle cells (SMC). FASEB J. 5:A1597, 1991.

111. Sehic, E., Ruan, Y., and Malik, K.U.: Renal vasoconstriction elicited by periarterial nerve stimulation is primarily due to release of adrenergic transmitter in the rat kidney. FASEB J. 6: A1022, 1992.

112. Schwartz, D.D. and Malik, K.U.: Alpha-2 adrenergic receptor mediated inhibition of [3H] norepinephrine release in neuronal cells is blocked by pertussis toxin. FASEB J. 6:A1022, 1992.

113. Cano, C. and Malik, K.U.: Loss of adenosine induced negative inotropic effect in hearts isolated from hyperexcited rabbits or treated with protein kinase C (PKC) activators. FASEB J. 6:A1311, 1992.

114. Nebigil, C. and Malik, K.U.: Pertussis (PTX) inhibits alpha-1A and alpha-2B adrenergic receptor (AR) stimulated prostaglandin (PG) synthesis and increases in cytosolic calcium in rabbit aortic smooth muscle cells (SMC). FASEB J. 5:A1597, 1992.

115. Lew, D.B. and Malik, K.U.: Mitogenic effect of β-hexosaminidase (HEX) on bovine tracheal myocytes (BTM) is

mediated via activation of protein kinase C (PKC). FASEB J. A1633, 1992. 116. Oellerich, W.F., Schwartz, D.D., and Malik, K.U.: Neuropeptide Y (NPY) inhibits norepinephrine release in cultured

sympathetic nerves by restricting the availability of calcium through a pertussis toxin sensitive mechanism. FASEB J. 7:A34, 1993.

117. Kan, H., Ruan, Y., and Malik, K.U.: Characterization of muscarinic receptors and their signalling mechanisms involved in prostacyclin production in endothelial cells of rabbit heart. FASEB J. 7:A44, 1993.

118. Oriji, G.K., Wright, H.M., Slavik, K.J., and Malik, K.U.: Adenosine-induced direct negative inotropic effect is abolished during global ischemia due to activation of protein kinase C (PKC) in the rat heart. FASEB J. 7:A93, 1993.

119. Schwartz, D.D. and Malik, K.U.: Angiotensin II-alpha-2 adrenergic receptor (AR)cross signalling in cultured sympathetic nerves. FASEB J. 7:A180, 1993.


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120. Ruan, Y., Kan, H., and Malik, K.U.: Modulation by adenosine 3'5'-cyclic monophosphate (cAMP) of beta-adrenergic receptor (β-AR) stimulated prostacyclin (PGI2) synthesis in rabbit ventricular myocytes. FASEB J. 7:1472, 1993.

121. Slavik, K.J. and Malik, K.U.: Differential antagonism by 7,7-dimethyleicosadienoic acid (DEDA) of prostacyclin synthesis elicited by angiotensin II (AII), isoproterenol (IPNE) and acetylcholine (ACh) in isolated perfused rabbit heart. FASEB J. 7:A652, 1993.

122. Lew, D.B., Murff, H.I. and Malik, K.U.: Contribution of extra-and intra-cellular Ca2+ in β-hexosaminidase (HEX)-induced mitogenesis in bovine airway smooth muscle (ASM) cells. FASEB J. 8:269, 1994.

123. Ruan, Y., Kan, H., and Malik, K.U.: Beta adrenergic receptor (β-AR) stimulated prostacyclin (PGI2) synthesis is modulated by adenosine 3'5'-cyclic monophosphate (cAMP) in rabbit coronary endothelial cells. FASEB J. 8:356, 1994.

124. Kan, H., Ruan, Y., and Malik, K.U.: Acetylcholine-induced prostacyclin synthesis is mediated by influx of Ca2+ via receptor operated Ca2+ channels by a pertussisToxin insensitive G protein due to activation of type II phospholipase(s) A2 in cultured endothelial cells of rabbit heart. FASEB J. 8:358, 1994.

125. Wright, H.M. and Malik, K.U.: Effect of phosphatase inhibitors on phospholipase A2 activity and prostacyclin synthesis in rat vascular smooth muscle cells. FASEB J. 8:358, 1994.

126. Oriji, G.K., Wright, H.M., and Malik, K.U.: Propranolol, but not other beta-blockers, restores the direct negative inotropic affect of adenosine abolished in the globally ischemic rat heart. FASEB J. 8:559, 1994.

126. Schwartz, D.D. and Malik, K.U.: Activation of L type calcium channels by angiotensin II (AII) in cultured sympathetic nerves. FASEB J. 8:626, 1994.

127. Kan, H., Ruan, Y. and Malik, K.U.: Acetylcholine stimulates prostacyclin synthesis in rabbit coronary endothelial cells via activation of Type II phospholipase A2 by a mechanism independent of phospholipase C(PLC), protein

kinase (C(PKC) or NO synthase. FASEB J. 9:A111, 1995. 128. Lew, D.B., Brown, E.R., Dempsey, B.K. and Malik, K.U.: Activation of protein kinase C (PKC) and mitogen activated

protein kinase (MAPK) by mannose-rich glycoprotein in airway smooth muscle cells (ASMC). FASEB J. 9:A698, 1995.

129. Olanrewaju, H.A., Malik, K.U., Kan, H. and Mustafa, S.J.: Adenosine receptor-mediated production of nitric oxide in bovine pulmonary and rabbit coronary endothelial cells. FASEB J. 9:A909, 1995.

130. Wright, H.M. and Malik, K.U.: Prostacyclin synthesis elicited by endothelin-1 in rat aorta is mediated by an endothelin type A receptor. Hypertension 25:1378, 1995.

131. Muthalif, M.M., Benter, I.F. and Malik, K.U.: Cytosolic phospholipase A2 (cPLA2) and MAP and CaM kinases are involved in norepinephrine (NE) stimulated arachidonic acid (AA) release and prostanoid synthesis in rabbit vascular smooth muscle cells (RASMC): An Antisense Approach. 9th International Conference on Second Messengers & Phosphoproteins-Abstracts 143:1995.

132. Muthalif, M.M., Damadzic, R., Lanier, S.M. and Malik, K.U.: Arachidonic acid (AA) release elicited by norepinephrine (NE) is mediated by cytosolic PLA2 (cPLA2) and MAP kinase in PC-12 and NIH 3T3 cells transfected with alpha2-adrenergic receptor subtypes. ASPET Colloquium Alpha2-Adrenergic Receptors: Structure, Function and Therapeutic Implications. Abstracts D9, 1995.

133. Muthalif, M.M., Benter, I.F. and Malik, K.U.: Cytosolic phospholipase A2 (cPLA2) and MAP and CaM kinases are

involved in norepinephrine (NE) stimulated arachidonic acid (AA) release and prostanoid synthesis in rabbit vascular smooth muscle cells (RASMC): An antisense approach. Ninth International Conference on Second Messengers & Phosphoproteins Abstract 143:1995.

134. Muthalif, M.M., Damadzic, R., Lanier, S.M. and Malik, K.U.: Arachidonic acid (AA) release elicited by norepinephrine (NE) is mediated by cytosolic PLA2 (cPLA2) and MAP kinase in PC-12 and NIH 3T3 cells transfected


32

CURRICULUM VITAE

with alpha2-adrenergic receptor subtypes. ASPET Colloquium Alpha2-Adrenergic Receptors: Structure, Function and Therapeutic Implications. Abstract D9, 1995.

135. Muthalif, M.M., Benter, I.F., Uddin, M.R. and Malik, K.U.: Signal transduction mechanisms involved in angiotensin-(1-7) [Ang(1-7)] stimulated arachidonic acid (AA) release and prostanoid synthesis (PG) in rabbit vascular smooth muscle cells (VSMC). FASEB J.: A23, 1996.

136. Wright, H.M. and Malik, K.U.: Prostacyclin (PGI2) synthesis elicited by endothelin-1(ET-1) in rat aorta is mediated by a pertussis toxin-insensitive G protein via activation of phospholipase (PL)D, by not PLC or PLA2. FASEB J. 10: A146, 1996.

137. Ruan Y., Kan, H., Allen, L.F., and Malik, K.U.: Inhibition by cyclic Adenosine 3', 5' monophosphate (cAMP) or arachidonic acid (AA) release elicited by phenylephrine (PE) in rat-1 fibroblasts transfected with alpha-K adrenergic receptor (AR). FASEB J. 10: A146, 1996.

138. Kan, H., Ruan, Y., and Malik, K.U.: Involvement of mitogen activated protein kinase (MAPK) and cytosolic phospholipase A2(cPLA2) translocation to nuclear envelope in acetylcholine (ACh) induced prostacyclin synthesis in coronary endothelial cells of rabbit heart. FASEB J. 10: A146, 1996.

139. Malik, K.U., Muthalif, M.M., Benter, I.F., and Al-Sibai, W.: Ca2+/CaM-dependent protein kinase II (CaMK II) mediates activation of MAP kinase (MAPK) and cytosolic phospholipase A2 (cPLA2) in norepinephrine (NE) induced arachidonic acid (AA) release in rabbit vascular smooth muscle cells (VSMC). FASEB J. 10: A413, 1996.

140. Ruan, Y., Kan, H., and Malik, K.U.: Beta-adrenergic receptors stimulated prostacyclin synthesis in rabbit coronary endothelial cells in mediated by selective activation of phospholipase D: Inhibition by cAMP. The Pharmacologist 39: 65 (A236), 1997.

141. Ibrahim, F.B., Muthalif, M.M., Uddin, M.R., Karzoun, N-A., and Malik, K.U.: Mechanism involved in angiotensin (Ang) 1-7 and II stimulated arachidonic acid (AA) release and prostanoid synthesis (PG) in rabbit vascular smooth muscle cells (VSMC). Microcirculation 4:183, 1997.

142. Muthalif, M.M., Adl, M.Z., Benter, I.F., and Malik, K.U.: Contribution of phospholipase D (PLD) in norepinephrine (NE) stimulated arachidonic acid (AA) release and prostacyclin (PGI2) synthesis in rabbit vascular smooth muscle cells (VSMC). Microcirculation 4:183, 1997.

143. Fatima, S., Muthalif, M., and Malik, K.U.: Norepinephrine-induced translocation of cytosolic phospholipase A2 (cPLA2) from the cytoplasma to the nuclear envelope is mediated by CaM, CaMKII, and MAPK in rabbit vascular smooth muscle cells (VSMC). Microcirculation 4:183, 1997.

144. Ruan, Y., Parmentier, J.H., Ahmed, A., Allen, L.F., and Malik, K.U.: Involvement of calcium/calmodulin kinase II (CaMKII), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) in the release of arachidonic acid (AA) elicited by phenylephrine (PE) via selective activation of phospholipase D in rat-1 fibroblasts transfected with alpha1 a/c adrenergic receptor (AR). FASEB J. 11:A111, 1997.

145. Muthalif, M.M., Karzoun, N., Benter, I.F., Harper, J., Uddin, M.R., and Malik, K.U.: Mechanism of caM kinase II (CaMKII) mediated MAP kinase (MAPK) activation by norepinephrine (NE) in vascular smooth muscle cells (VSMC). Involvement of cytochrome P-450 (CYP-450) and lipoxygenase (LO) metabolites of arachidonic acid (AA). FASEB J. 12:A403, 1998.

146. Parmentier, J.H., Ruan, Y., Ahmed, A., Saeed, A.E., Allen, L.F., and Malik, K.U.: Phenylephrine (PHE)-stimulated phospholipase D (PLD) activity and arachidonic acid (AA) release is mediated by the synergistic action of calcium (Ca2+) and protein kinase C (PKC) in rat-1 fibroblasts transfected with α1 A adrenergic receptor (AR). FASEB J. 12:A446, 1998.

147. Fatima, S., Muthalif, M.M., Ahmed, A., and Malik, K.U.: Involvement of Ras/MEK/MAPK in norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope. FASEB J. 12:A447, 1998.


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148. Parmentier, J-H, Muthalif, M.M., Ahmed, A., Saeed, A.E. and Malik, K.U. Phospholipase D activation by norepinephrine contributes to arachidonic acid release and is mediated by the ras/mitogen-activated protein kinase pathway in rabbit vascular smooth muscle cells. FASEB Journal 13:A137, 1999.

149. Benter, I.F., Muthalif, M.M., Karzoun, N., Malik, S.F. and Malik, K.U. Contribution of Ras GTPase to the development of angiotensin II-induced hypertension. FASEB Journal 13:A484, 1999.

150. Muthalif, M.M., Harper, J., Karzoun, N., Benter, I.F., Dress, M. and Malik, K.U. Cytosolicphospholipase A2 (cPLA2) is phosphorylated and activated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). FASEB Journal

13:A1095, 1999. 151. Muthalif, M.M., Benter, I.F., Khandekar, Z., Gaber, L., Estes, A., Malik, S., Manne, V. and Malik, K.U. Contribution

of Ras GTPase/MAP kinase and cytochrome P-450 metabolites to deoxycorticosterone-salt hypertension. Abstracts of the Council for High Blood Pressure Research 53rd Annual Fall Conference and Scientific Sessions.

Hypertension August 8, 1999. 152. Muthalif, M.M., Harper, J., Ljuca, F., Karzoun, N. and Malik, K.U.: Mechanism of activation of cytosolic

phospholipase A2 (cPLA2) by Ca2+/calmodulin dependent protein kinase II (CaM kinase II). FASEB Journal 14: A1463, 2000.

153. Parmentier, J-H., Ruan, Y., Ahmed, A., Sneed, A.E. and Malik, K.U.: Phorbol 12-myristate acetate inhibits alpha-1A adrenergic receptor stimulated phospholipase D (PLD) activity through Rho A depletion. FASEB Journal 14: A14 63, 2000.

154. Kalyankrishina, S., Parmentier, J. H. and Malik, K.U.: Arachidonic acid-induced vascular smooth muscle call apoptosis; modulation by cytoprotective agents. FASEB Journal 14: A1564, 2000.

155. Fatima, S. Ahmed, A. and Malik, K U.: Calcium/calmodulin-dependent protein kinase II mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope in vascular smooth muscle cells. FASEB Journal 14: A1579, 2000.

156. Fatima, S., Khandekar, Z., Malik, K.U. Norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope via the mitogen-activated protein kinase pathway requires actin filament polymerization in rabbit vascular smooth muscle cells. FASEB J. 15:A542, 2001.

157. Saeed, A.E., Parmentier, J-H., Malik, K.U. Phenylephrine-induced inhibition of cell proliferation is mediated by a mechanism independent of cyclic AMP in rat-1 fibroblasts expressing alpha-1 adrenergic receptors. FASEB J. 15:A565, 2001.

158. Parmentier, J-H., Gandhi, G.G. and Malik, K.U. Protein kinase Cζ mediates phospholipase D activation in rat-1 cells expressing the alpha-1A adrenergic receptor. FASEB J. 15:A884, 2001.

159. Muthalif, M., Nguyen, B., Uddin, M. and Malik, K.U. CaM kinase II mediates angiotensin II-induced transactivation of epidermal growth factor receptor and hypertrophy of vascular smooth muscle cells. FASEB J. 15:A929, 2001

160. Muthalif, M.M., Uddin, M.R. , Gaber, L., Karzoun, N., Benter, I. F., Khandekar, Z., Estes, A. and Malik, K.U. Functional significance of activation of calcium/calmodulin dependent kinase (CaM kinase II) in angiotensin II-induced vascular hyperplasia and hypertension. Abstracts of 55th Annual conference of Council for High Blood Pressure, Hyperension, 15, October 2001.

161. Parmentier, J-H., Amed, A., Gandhi, G.K, Malik, K.U. Contribution of calcium signaling to phospholipase D activity in rat-1 fibroblasts expressing α-1 H adrenergic receptors. FASEB J. 16:A160,2002

162. Kalyankrishna, S. and Malik, K.U. Norepinephrine – induced phospholipase D(PLD) activation is mediated by p38 mitogen activated protein kinase (p38MAPK) in rabbit vascular smooth muscle cells (VSMCs). FASEB J. 16:A935, 2002

163. Li, F. and Malik, K.U. Angiotensin II-induced stimulation of Akt/PKB is dependent on phospholipase D (PLD) activation in rat aortic vascular smooth muscle cells (VSMC). FASEB J. 16:A937, 2002.

164. Fang, L. and Malik, K.U. Cytosolic phospholipase A2 mediates angiotensin II-stimulated Akt phosphorylation. FASEB J. 17: A1031, 2003


34

CURRICULUM VITAE

165. Yaghini, A.Y., Fatima, S. and Malik, K.U. Angiotensin II stimulates p72syk phosphorylation via p38MAPK and PKCζ in vascular smooth muscle cells. FASEB J. 17: A1032, 2003.

166. Fatima, S., Yaghini, F.A. and Malik, K. U. Norepinephrine-induced cPLA2 translocation to the nuclear envelope but not its activation is dependent upon intact actin filaments. FASEB J. 17: 1033, 2003.

167. Kalyankrishna, S. and Malik, K.U. Contribution of epidermal growth factor receptor transactivation to G-protein coupled receptor signaling varies between agonists, and vascular smooth muscle cells from different species. FASEB J. 17: A1037, 2003.

168. Parmentier, J.H., Zhang, C., Kalyankrishna, S., Estes, A. and Malik, K.U. Inhibition of PKCζ: A novel strategy for attenuation of neointimal formation by angiotensin II in balloon injured carotid artery. Page 63 of the Abstracts of 57th Annual Fall Conference of the Council for High Blood Pressure Research, Washinton, D.C., September 23-26, 2003.

169. Fang, L. and Malik, K.U. Angiotensin II-induced Akt/PKB activation is mediated through stimulation of cPLA2-dependent PLD activity. FASEB J. 18: A233, 2004.

170. Parmentier, J.H. and Malik, K.U. Norepinphrine-induced phospholipase D activation is independent of cytochrome P450 and 4F in aortic vascular smooth muscle cells. FASEB J. 18: A233, 2004.

171. Tunctan, B., Yaghini, F..A., Estes, A., and Malik, K.U. Prostaglandins inhibit cytochrome P450A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production. FASEB J. 18: A1034, 2004.

172. Tunctan, B., Yaghini, F.A., Estes, A. and Malik, K.U. Inhibition by nitric oxide of cytochrome P450A activity contributes to endotoxin induced hypotension in rats. FASEB J. 18: A1037, 2004.

173. Li, F, Zhang C, Schaefer, S, and Malik K. U.: Ang II-Induced Neointimal Growth is Mediated via cPLA2 and PLD2 Activated Akt in balloon-injured rat Carotid Artery. FASEB J. 19: A1559, 2005.

174. Parmentier JH, Saeed AE and Malik KU. Activation of alpha-1A adrenergic receptor promotes differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype. FASEB J., 19: A537, 2005.

175. Parmentier JH, Capdevila JH, Falck JR and Malik KU. 11, 12-epoxyeicosatrienoic acid stimulates phospholipase D activity but does not mediate the effect of norepinephrine in VSMC . FASEB J., 19: A539, 2005.

176. Yaghini FA, Zhang C, Parmentier JH, Estes A, Malik KU. Contribution of arachidonic acid metabolite(s) derived via cytochrome P4504A1 to angiotensin II-induced neointimal formation inballoon-injured rat carotid artery. Abstracts of the Council for High Blood Pressure, Hypertension 44: 536,2004.

177. Parmentier, J-H. and Malik, K.U. Cytochrome P450 CYP1B1 isoform mediates phospholipase D activation by norepinephrine in vascular smooth muscle cells. EB J. 20: 149, 2006.

178. Pavicevic, Z., Leslie, C. C. and Malik, K. U. Phosphorylation of cytosolic phospholipase A2 at Ser505 is dependent upon phosphorylation at Ser515 in response to norepinephrine in vascular smooth muscle cells. EB J. 15, 2007.

179. Lavrentyev, E. and Malik, K.U. High glucose down-regulates ACE2 mRNA expression and protein levels which is associated with decrease In Ang (1-7) formation in rat VSMC. Hypertension, 50(4): e150, 2007.

180. Yaghini, F. A., Mugabe, B. E., Estes, A. M., and Malik, K. U. Angiotensin II-induced hypertrophy and proliferation are mediated by p38 MAPK activated c-Src, and proliferation but not hypertrophy is dependent on epidermal growth factor receptor transactivation in rat vascular smooth muscle cells. Hypertension, 50(4): e111, 2007.

181. Mugabe B. E., Yaghini F. A., Buharalioglu C. K. and Malik K. U. Angiotensin II-induced migration of vascular smooth muscle cells (VSMCs) is mediated by both 72-KDa spleen tyrosine kinase (Syk) via p38-MAPK activated c-Src and by ERK1/2 via c-Src-induced EGFR transactivation . The FASEB Journal, 22:911.4., 2008.

182. Yaghini F. A., Mugabe B. E., Buharalioglu C. K., Estes A. M. and Malik K. U. Mechanism of angiotensin II-induced c-Src activation in Vascular Smooth Muscle Cells. The FASEB Journal. 2008;22:911.5., 2008.

183. Tunctan B., Korkmaz B., Buharalioglu C. K., Sahan-Firat S., Anjaiah S., Falck J. R., Yildirim H., Tamer L., Roman R. J. and Malik K. U. 20-HETE agonist, N-[20- hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the endotoxin-induced fall in blood pressure and the decrease in vascular reactivity and lipid peroxidation and increased catalase activity via inhibition of NO production in rats . The FASEB Journal. 2008 22:1128.1, 2008.


35

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184. Lavrentyev E. N. and Malik K. U. High glucose (HG)-induced angiotensin-converting enzyme 2 (ACE2) and angiotensin (1–7) [Ang (1–7)] decrease is prevented by captopril, losartan and insulin in rat vascular smooth muscle cells (VSMCs). The FASEB Journal. 22:912.18, 2008.

185. Buharalioglu, C. K., Song, C. Y., Yaghini, F. A., Ghafoor, H. U., Estes, A., and Malik, K. U. Spleen tyrosine kinase mediates angiotensin II- and Vascular endothelial growth factor-induced angiogenesis. FASEB Journal, 23:625.9, 2009.

186. Tunctan, B., Karmaz, B., Cuez, T., Firat S. S., Yidrim, H., Tamer, L., Buharalioglu, C. K., Falck, J.R. and Malik, K. U. Increased production of 20-HETE contributes to the effects of COX inhibitors to prevent the decrease in lipid peroxidation and increase in catalase activity during endotoxemia. FASEB Journal, 23: 937.13, 2009.

187. Buharalioglu, C. K., Song, C. Y. , Yaghini, F. A. Ghafoor, U. H. Estes, A. M. and Malik, K. U. Angiotensin II–Induced Angiogenesis Is Mediated by SpleenTyrosine Kinase via Epidermal Growth Factor Receptor–Stimulated Vascular Endothelial Growth Factor Receptor 1 Phosphorylation Independent of Vascular Endothelial Growth Factor Expression, Hypertension, 54: e73, 2009

188. Yaghini, F. A., Song, C. Y., Lavrentyev, E. N., Fang, X. R., Estes, A. M., Campbell, W. B., and Malik, K. U. Angiotensin II–induced vascular smooth muscle cell migration, proliferation, and hypertrophy are mediated by cytochromeP450 1B1-dependent superoxide generation. Hypertension. 54: e122, 2009.

189. Jennings, B. L., Das, K., Sahan-Firat, S., Estes, A. M., Malik. K. U. Contribution of cytochrome P450 1B1 to angiotensin II–induced hypertension. 54:e44, 2009.

190. Song C. Y., Yaghini FA., Tolkachjov, S. T., Estes A. M., Fang, X. R. Malik, K. U. Angiotensin II-induced Neointimal Growth In Balloon Injured Rat Carotid Artery Is Dependent Upon Cytochrome P450 1B1. Hypertension 54: e121, 2009.

191. Sahan Firat, S., Jennings, B. L., Estes, A M., Farjana, N., Khan, X. R., Fang, X. R., and Malik, K. U. DOCA/salt-induced hypertension and associated increase in vascular reactivity and cardiac and vascular hypertrophy are mediated by cytochrome P450 1B1. FASEB J. 24:786.16, 2010.

192. Jennings, B. L. Sahan-Firat, S., Estes, A. M. and Malik, K.U. Contribution of cytochrome (CYP) 450 1B1 in various models of hypertension in rats and mice: A novel target for the development of ant-hypertensive agents. FASEB J. 24: 786.23, 2010.

193. Song, C. Y., Ghafoor, H. U. B., Yaghini, F. A., Fang, X. R., and Malik, K. U. Angiotensin II-induced reactive oxygen radical production by NAD (P) H oxidase is mediated by arachidnic acid metabolism via cytochrome P4501B1 in vascular smooth muscle cells. FASEB J. 24: 962.6, 2010.

194. Yaghini, F. A., Estes, E. M., Buckley, T. H., Malik, K. U. Cytochrome P450 1B1 Gene deletion prevents angiotensin II-induced inflammation and neointimal formation post carotid artery injury in mice. Hypertension. 56: 154, 2010.

195. Jennings, L. B., Estes, A. M. and Malik, K. U.Cytochrome P450 1B1 gene Deletion prevents DOCA-salt-induced hypertension and associated cardiovascular changes in mice. Hypertension. 56: e110, 2010.

196. Jennings, L. B., Porter, J., Estes, A. E. and Mailk, K U. Cytochrome P4501B1 is required for increased thirst and changes in renal function associated with angiotensin II-induced hypertension in mice. Hypertension. 56: e111, 2010.

197. Jennings, B. L., Anderson, L. J., Estes, A. M., and Mailk, K. U. Inhibition of cytochrome P4501B1 activity with 2,3′,4,5′-tetramethoxystilbene prevents renal dysfunction associated with angiotensin II-induced hypertension in rats. Hypertension. 56: e121, 2010.

198. Jennings, B. L., Anderson, L. J., Estes, A. M. and Malik, K. U. Inhibition of cytochrome P450 1B1 activity prevents renal injury and inflammation associated with angiotensin II induced hypertension in rats. FASEB J. 25: 1030(4), 2011.

199. Jennings, B. L., Estes, A. M. and Malik, K. U. Cytochrome P450 1B1 gene disruption minimizes L-NAME-induced hypertension and associated cardiovascular changes in mice. Hypertension. 58: e130, 2011.

200. Jennings, B. L., Estes, A. M., Yaghini,F. A., Fan, Z., and Malik, K. U. Cytochrome P450 1B1 gene disruption prevents cardiac dysfunction associated with DOCA-salt-induced hypertension in mice. Hypertension. 2012;60:A121,


36

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201. Khan, N.S., Jennings, B. L., Song, C.Y. Estes, A.M., Bonventre, J. V. and Malik, K.U. A critical role of group IV cytosolic phospholipase A2{alpha} in the development of Ang II-induced hypertension and associated cardiovascular pathophysiology. Hypertension. 60:A229, 2012.

202. Jennings, B. L., Montanez, D. E., Estes, A. M., Yaghini, F. A. and Malik, K. U. 2,4,3',5'-Tetramethoxystilbene reduces blood pressure and associated cardiac fibrosis via inhibition of cytochrome p450 1B1 and decreased oxidative stress in SHR. FASEB J. 27:1108.6 : 2013.

204. Song, C. Y., Jennings, B. L., Lin, J., Fang, X.R.and Malik, K. U. Signaling mechanism of cytochrome p450 1B1-dependent angiotensin II-induced activation of NADPH oxidase in vascular smooth muscle cells. FASEB J. 27:1142.11, 2013

205. Pingili, A.K., Jennings, B.L., Khan, N. S. and Malik, K.U. 6β- Hydroxytestosterone, A cytochrome P450 1B1 metabolite of testosterone, enhances angiotensin II-induced pressor effect in male mice. Hypertension. 2013;62:A252.

206. Ghafoor, K., Ghafoor, H.U, Jennings, B. L, Khan, N. S., Thirunavukkarasu, S., Song CY, Zaidi, S., Estes, A.M. and Malik, K. U. Cytochrome P450 1B1 is critical for the development of atherosclerosis and hypertension in ApoE knockout mice. Hypertension. 2013;62:A262.

207. Jennings, B. L, Pingili, A. K., Khan, N. S, and Malik KU. Modulation of angiotensin II-induced hypertension by cytochrome P450 1B1 metabolites of estrogen in female mice. Hypertension. 2013;62:A249.

208. Song, C.Y, Khan, N. S, Fang, X. R, Liao, F. F, Wang, B., Bonventre, J. V, and Malik, K. U. Cytosolic phospholipase A2α in brain subfornical organ is critical for angiotensin II-induced ER and oxidative stress and hypertension. Hypertension. 2013;62:A178.

209. Song, C. Y., Jennings, B. L., Lin, J., Fang, X. R., Malik, K. U. (2013). Signaling mechanism of cytochrome P450 1B1-dependent angiotensin II-induced activation of NADPH oxidase in vascular smooth muscle cells. FASEB J. 27:1142.11

1966 Sep - 30th Tagung der Deutschen Pharmakologischen Gesellschaft, Keil, Germany 1967 Mar - 8th Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, Germany 1969 Jun - 12th Canadian Federation of Biological Societies, Edmonton, Canada 1969 Jul - 4th International Congress of Pharmacology, Basel, Switzerland 1971 Apr- 55th Annual Meeting of Federation of American Societies for Experimental Biology, Chicago, Illinois, USA 1972 Apr- 56th Annual Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New

Jersey, USA 1973 Apr- 57th Annual Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New

Jersey, USA 1974 Aug- Fall Meeting of American Society for Pharmacology and Experimental Therapeutics, Lansing, Michigan,

USA 1975 Apr- 59th Annual Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New

SCIENTIFIC MEETINGS AT WHICH PAPERS WERE PRESENTED:


37

CURRICULUM VITAE

Jersey, USA 1975 Jul- Sixth International Congress of Pharmacology, Finland 1976 Apr- 60th Annual Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, USA 1976 Aug- Fall Meeting of American Society for Pharmacology and Experimental Therapeutics, new Orleans,

Louisiana, USA 1977 Apr- 61st Annual Meeting of Federation of American Societies for Experimental Biology, Chicago, Illinois, USA 1978 Apr- 62nd Annual Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New

Jersey, USA 1978 Jun- ASBC/AAI Annual Meeting of Federation of American Societies for Experimental Biology, Atlanta,

Georgia, USA 1978 Jul- 7th International Congress of Pharmacology, Paris France 1978 Aug- Fall Meeting of American Society for Pharmacology and Experimental Therapeutics Society of Toxicology,

Houston, Texas, USA 1979 Mar- 63rd Annual Meeting of Federation of American Societies for Experimental Biology, Dallas, Texas, USA 1980 Apr- 64th Annual Meeting of Federation of American Societies for Experimental Biology, Anaheim, California,

USA 1980 May- Seventh Scientific Meeting of the International Society of Hypertension, New Orleans, Louisiana, USA 1980 Aug- Fall ASPET Meeting, Rochester, Minnesota (Mayo Medical School), USA 1981 Jan- Gordon Research conference, Ventura, California, USA 1981 Apr- 65th Annual Meeting of Federation of American Societies for Experimental Biology, Atlanta, Georgia,

USA 1982 Apr- 66th Annual Meeting of Federation of American Societies for Experimental Biology, New Orleans,

Louisiana, USA 1982 Aug- American society of Pharmacology and Experimental Therapeutics, Louisville, Kentcky, USA 1982 Apr- 67th Annual Meeting of Federation of American Societies for Experimental Biology, Chicago, Illinois, USA


38

CURRICULUM VITAE

1983 Aug- Annual ASPET Meeting, Philadelphia, Pennsylvania, USA 1984 Apr- 68th Annual Meeting of Federation of American Societies for Experimental Biology, St. Louis, Missouri,

USA 1984 Aug- Annual ASPET Meeting, Indianapolis, Indiana, USA 1985 Apr- 69th Annual Meeting of Federation of American Society of Experimental Biology, Anaheim, California,

USA 1985 Aug - Annual ASPET Meeting, Boston, Massachusetts, USA 1986 Apr- 70th Annual Meeting of Federation of American Societies for Experimental biology, St. Louis Missouri,

USA 1986 Nov - Society of Neurosciences Meeting, Washington, D.C., USA 1987 Apr- 71st Annual Meeting of Federation of American Societies for Experimental biology, Washington, D.C.,

USA 1988 May - 72nd Annual Meeting of Federation of American Societies for Experimental Biology, Las Vegas, USA 1988 Oct- Annual ASPET Meeting, Montreal, Canada 1989 Mar - 73rd Annual Meeting of Federation of American Societies for Experimental Biology, New

Orleans, Louisiana, USA 1989 Sep - Council for High Blood Pressure, Cleveland, Ohio, USA 1990 Apr - FASEB Meeting, Washington, D.C., USA 1990 May - International Congress on Prostaglandins and Leukotrienes, Florence, Italy 1990 Jul - XIth International Congress of Pharmacology, Amsterdam, The Netherlands 1990 Aug - Fall Meeting of American Society for Pharmacology and Experimental Therapeutics, Milwaukee,

Wisconsin, USA 1990 Oct - Council for High Blood Pressure, Baltimore, Maryland, USA 1991 Apr - FASEB Meeting, Atlanta, Georgia, USA 1992 Apr - FASEB Meeting, Anaheim, California, USA 1993 Apr - FASEB Meeting, New Orleans, Louisiana, USA


39

CURRICULUM VITAE

1994 Apr - FASEB Meeting, Anaheim, California, USA 1995 Sep- Council for High Blood Pressure, New Orleans, Louisiana, USA 1995 Oct - ASPET Colloquium Alpha2-Adrenergic Receptors: Structure, Function and Therapeutic Implications,

Nashville, Tennessee, USA 1995 Oct - 9th International Conference on Second Messengers and Phosphoproteins. Nashville, Tennessee, USA 1996 Apr - FASEB Meeting, Washington, D.C., USA 1997 Mar - Meeting of the American Society for Pharmacology and Experimental Therapeutics, San Diego, California,

USA 1997 Apr - Vascular Biology Meeting, New Orleans, Louisiana, USA 1997 Apr - FASEB Meeting, New Orleans, Louisiana, USA 1998 Apr - FASEB Meeting, San Francisco, Los Angeles, California, USA 1998 Sep - Council for High Blood Pressure, Philadelphia, Pennsylvania, USA 1999 Apr - FASEB Meeting, Washington, D.C., USA 1999 Sep - Council for High Blood Pressure, Orlando, Florida, USA 2000 Jun - FASEB Meeting, Boston, Massachusetts, USA 2000 Oct - Council for High Blood Pressure, Washington, D.C. USA 2001 Apr - FASEB Meeting, Orlando, Florida 2001 Sep - Council for High Blood Pressure, Chicago, IL, USA 2002 Apr- FASEB Meeting, New Orleans, LA, USA 2002 Sep- Council for High Blood Pressure, Orlando, Florida, USA 2003 Apr- EB Meeting, San Diego, California, USA 2004 Apr- EB Meeting, Washington, D.C., USA 2004 Sep- Council for High Blood Pressure, Chicago, Illinois, USA 2005 Apr- EB Meeting, San Diego, California, USA 2005 Nov- Serbian Physiological Society Meeting with International Participation


40

CURRICULUM VITAE

Belgrade, Yugoslavia 2006 Mar- Winter Eicosanoid Meeting, Bethesda, Maryland, USA 2006 Apr- EB Meeting, San Francisco, California, USA 2007 Mar- Winter Eicosanoid Meeting, Bethesda, Maryland, USA 2007 Apr- EB Meeting, Washington, D.C., USA 2007 Sept- Council for High Blood Pressure, Tucson, Arizona, USA 2008 Apr- EB Meeting, San Diego, California, USA 2009 Apr- EB Meeting, New Orleans, LA., USA 2009 Sept- Council for High Blood Pressure Meeting, Chicago, IL., USA 2010 Apr- EB Meeting, Anaheim, CA., USA 2010 Sept- Council for High Blood Pressure, Washington, D.C., USA 2011 Mar- Winter Eicosanoid Meeting, Baltimore, Maryland USA 2011 Sept- Council for High Blood Pressure, Orlando, FL., USA 2012 Apr- EB Meeting, San Diego, CA., USA 2012 Sept- Council for High Blood Pressure, Washington, D.C., USA 2013 Apr- EB Meeting, Boston, MA. 2013 Sept- Council for High Blood Pressure, New Orleans, LA, USA 2014 Apr- EB Meeting, San Diego, California

INVITED LECTURES AND CONFERENCES:


41

CURRICULUM VITAE

Department of Pharmacology, Dalhousi University, Halifax, Nova Scotia, Canada, May 1967 Department of Pharmacology, University of Ottawa, Ottawa, Canada, May 1967 Department of Pharmacology, University of Alberta, Edmonton, Canada, April 1968 Department of Pharmacology, University of Oxford, Oxford, England, July 1969 Department of Pharmacology, Faculty of Medicine, Johannes-Gutenberg University of Mainz, Mainz, Germany, July

1969 Department of Pharmacology, Faculty of Medicine, University of Sarajevo, Sarajevo, Yugoslavia, July 1969 Department of Pharmacology, Faculty of Medicine, King Edward Medical College, University of Panjab, Lahore, Pakistan,

July 1969 Department of Pharmacology, School of Medicine, University of Singapore, Singapore, July 1969 Department of Pharmacology, School of Medicine, Mahidol University, Bangkok, Thailand, August 1969 Department of Pharmacology, School of Medicine, University of Los Angeles, Los Angeles, California, August 1969 Department of Pharmacology, School of Medicine, St. Louis University, St. Louis, Missouri, September 1969 Department of Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, May 1973 Department of Pharmacology, Post-Jinah Medical Center, Karachi, June 1973 Department of Pharmacology, University of Tennessee, The Health Science Center, Memphis, Tennessee, September

1974 Department of Pharmacology, University of Oxford, Oxford, England, June 1975 Wellcome Research Institute, Beckenham, England, June 1975 Symposium - Alteration in activity of vascular smooth muscle by local modulation of adrenergic transmitter release,

organized by the circulation group of the American Physiology Society at 61st Annual Meeting of FASEB, Chicago, April 1977

Third International Symposium of Vascular Neuroeffector Mechanisms, Catholic University of Antwerpen, Antwerpen,

Belgium, July 1978 Department of Internal Medicine, Faculty of Medicine, University of Tuzla, Yugoslavia, July 1978 Fourth International Prostaglandin Conference, Washington, D.C., May 1979


42

CURRICULUM VITAE

Fifth International Symposium on Atherosclerosis, Houston, Texas, November 1979 Sixth Kanematsu Conference on the Kidney, "Hormones and the Kidney," A Satellite Meeting of Sixth International Congress of Endocrinology, Sydney, Australia, February 1980 Department of Pharmacology, Monash University, Melbourne, Australia, February 1980 Gordon Research Conference on Kinins, Ventura, California, February 1981 Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, January 1982 St. Louis University, St. Louis, Missouri, May 1984 New York Medical College, Valhalla, New York, June 1984 Department of Pharmacology, College of Medicine, Milwaukee, Wisconsin, October 1984 Department of Pharmacology, School of Medicine, Shinshu University, Matsumoto, Japan, November 1984 Kyoto Conference on Prostaglandins, Kyoto, Japan, November 1984 Department of Biochemistry, Faculty of Medicine, Kurume University, Kurume, Japan, November 1984 Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan, November 1985 Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, December 1985 Department of Pharmacology, School of Medicine, Shreveport, Louisiana, November 1986 Inter-American Society of Hypertension Meeting, Buenos Aires, Argentina, April 1987 International Symposium In Honor of E. Eric Muirhead, "Antihypertensive and Hypertensive Mechanisms," Memphis,

Tennessee, October 1987 Department of Physiology, Georgetown University, School of Medicine, Washington, D.C., December 1987 Department of Pharmacology, School of Medicine, SUNY, Syracuse, New York, January 1988 Department of Pharmacology, School of Medicine, University of Nebraska, Omaha, Nebraska, March 1988 Taipei Conference on Prostaglandin and Leukotriene Research, April 1988 Department of Pharmacology, School of Medicine, The University of Connecticut Center for Health Sciences,

Farmington, September 1988


43

CURRICULUM VITAE

Department of Pharmacology, School of Medicine, University of Buffalo, Buffalo, New York, 1988 Southeastern Pharmacology Society Symposium "Advances in Cardiopulmonary Pharmacology. Medical College of

Georgia, Augusta, Georgia, September, 1989 The New York Academy of Sciences, "Presynaptic Receptors and the Question of Autoregulation of Neurotransmitter

Release. Philadelphia, Pennsylvania, December 4-6, 1989 Department of Pharmacology, School of Medicine, University of Kentucky, Lexington, Kentucky, March, 1990 Department of Pharmacology, The Medical College of Philadelphia, Philadelphia, Pennsylvania, March, 1990 Department of Pharmacology, School of Medicine, Emory University, Atlanta, Georgia, April, 1990 Department of Pharmacology, The University of Texas Health Science Center at San Antonio, Texas, May, 1990 Department of Physiology, School of Medicine, Georgetown University, Washington, D.C., March, 1991 Department of Pharmacology, School of Medicine, The University of Texas Health Science Center at San Antonio, Texas December, 1991 Department of Pharmacology, School of Medicine, Kansas University, Kansas City, Kansas, April, 1992 Department of Physiology, School of Medicine, West Virginia University, Morgantown, West Virginia, December, 1992 Department of Anatomy, School of Medicine, University of Tennessee, Memphis, March, 1993 Department of Cell Biology, School of Osteopathic Medicine, Stratford, New Jersey, August, 1994 International Congress of Clinical Pharmacology, Buenos Aires, Argentina, August, 1996 New York Medical College, Valhalla, New York, May, 1997 Vanderbilt University, Nashville, Tennessee, March, 1998 Christian Brothers University, Memphis, Tennessee, April, 1998 University of Kentucky, Louisville, Kentucky, May, 1998 Winter Eicosanoids Conference, Baltimore, MD, March, 1998. Winter Eicosanoids Conference, Baltimore, MD, March, 1999. Winter Eicosanoids Conference, Baltimore, MD, March, 2000


44

CURRICULUM VITAE

Winter Eicosanoids Conference, Baltimore, MD, March, 2001 Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, Texas, 2001 Department of Cell Biology, University of Medicine, Osteopathic School of Medicine , Stratford, NJ, 2002. Department of Pharmacology, School of Medicine, Louisiana State University, New Orleans, LA, 2002. Department of Pharmacology, East Carolina Medical School, University of East Carolina, N.C. 2003. Department of Pharmaceutical Sciences, Johanes-Gutenberg University of Mainz, Germany, 2003. Department of Pharmacology, Shinshu University, Matsumoto, Japan, 2003. Azwell Inc., Osaka, Japan, 2003. Serbian Physiological Society with International Participation, Belgrade,Yugoslavia, 2005. Department of Pharmacology, New York Medical College, Valhalla, New York, 2007

Division of Rheumatology, Department of Medicine, UTHSC, 2009 Division of Cardiology, Department of Medicine, UTHSC, 2010 Winter Eicosanoid Meeting, Baltimore, Maryland, 2011 Workshop on “Eicosanoids in cardiovascular disease” Erice, Sicily, 2011 Department of Pharmacology, School of Medicine, University of Mississippi, Jackson, MS, 2013

Current

Active NIH/NHLBI- HL-1RO1 HL079109-08, Principal Investigator. Eicosanoids-Induced Vascular Growth During Injury. 12/01/11

– 11/30/15, Direct costs $ 1,074,760. Direct costs for the Project Period 2014/2015, $231,750.

NIH/NHLBI -HL-R01-19134-37, Principal Investigator. Angiotensin-Prostaglandins-Adrenergic Interactions, 04/01/13- 03/31/18, Direct Costs $1,899,353. Direct Costs for the Project Period 2013/2014: $375,519 Past

INDEPENDET RESEARCH SUPPORT:


45

CURRICULUM VITAE

NIH/NHLBI -HL-R01-19134-37, Principal Investigator. Angiotensin-Prostaglandins-Adrenergic Interactions, 04/01/ 8- 08/31/13, Direct Costs $2,305,574. Direct Costs for the Project Period 2012/2013: $351,978

NIH/NHLBI- HL-1RO1 HL079109-05, Principal Investigator. Eicosanoids-Induced Vascular Growth During Injury. 01/01/05 – 12/31/10, Direct costs $ 1,250, 000. Direct costs for the Project Period 2009/2010, $358,438.

NIH/NHLBI -HL-R01-19134-32, Principal Investigator., 09/01/ 02- 08/31/07, Direct Costs $1,747,305+Indirect $632,868, Total: $2,380,173, Angiotensin-Prostaglandins-Adrenergic Interactions

NIH-HL Grant 19134-09/01/1997 - 08/31/2002- Direct cost $1,550,362 + Indirect cost 651,152, Total: $2,201,514 Angiotensin-Prostaglandins-Adrenergic Interactions NIH-HL Grant 19134 (Merit Award) 09/01/1992 - 08/31/1997- Direct cost $ 1,156,523+ Indirect cost $ 485,739 09/01/1987 - 08/31/1992-Direct cost $1,121,457 + Indirect cost $ 448,582 Angiotensin-Prostaglandins-Adrenergic

Interactions American Heart Association –Southern Affiliates –Principal Investigator– Summer Health Science Fellowship. Total Direct

Cost for the project period (2000 – 2002) $21,600 American Heart Association – Southern Affiliates –Principal Investigator –Summer Health Science Fellowship.Total Direct

Cost for the project period (1998-2000) $21,600.

NIH-HL Grant 3R37 HL1913-1851 (Minority Supplement for a Postdoctoral Fellow) 09/01/92 - 08/31/95 $147,524 American Heart Association– Southern Affiliates –Principal Investigator–Summer Health Science Fellowship. Total Direct

Cost for the project period (2000 – 2002) $21,600 American Heart Association– Southern Affiliates–Principal Investigator–Summer Health Science Fellowship. Total Direct

Cost for the project period (1998-2000) $21,600. NIH-HL Grant 3R37 HL1913-1851 (Minority Supplement for a Postdoctoral Fellow) 09/01/92 - 08/31/95 $147,524 Tennessee Heart Association Grant - Angiotensin II-Prostaglandins and Adrenergic Transmission, 07/01/1981 -

06/30/1982 $9,356 NIH-HL Grant 19134 - Angiotensin-Prostaglandin-Adrenergic Interactions, 09/01/1982 - 08/30/1987 $783,466 American Heart Association Grant - Modulation by Kinins of Adrenergic Nervous Activity, 07/01/1977-06/30/1980

$70,000 NIH-HL Grant 19134 - Angiotensin-Prostaglandin-Adrenergic Interactions, 09/01/1977 - 08/30/1982 $359,910 NIH-HL Grant 5K04HL00142 (Research Career Development Award) Angiotensin-Prostaglandins-Adrenergic Interaction,

09/01/1975 - 08/30/1980 $170,000 Tennessee Heart Association Grant - Modulation of Neurotransmission in Blood Vessels, 07/01/1975- 06/30/1976


46

CURRICULUM VITAE

$10,030 NIH-HL Grant 20206 - Carbohydrates-Nucleotides and Adrenergic Interaction, 12/01/1976 - 11/30/1979 $82,570 NIH-HL Grant 19134 - Angiotensin - Prostaglandin-Adrenergic Interactions, 09/01/1974 - 06/31/1977 $76,032 American Heart Association Grant - Role of Carbohydrates in Adrenergic Transmission, 07/01/1973- 06/30/1974

$39,843 Wisconsin Heart Association Grant - Carbohydrates as Modulators of Adrenergic Transmission, 07/01/1973 - 06/31/1974

$9,950 Wisconsin Heart Association Grant - Adrenergic Modulatory Systems in Hypertension, 07/01/1972- 06/30/1973 $8,030 Wisconsin Heart Association Grant - Modification by Prostaglandins of Adrenergic Transmission in Renal and Mesenteric

Blood Vessels in Normotensive and Hypertensive Animals, 07/01/1971- 06/31/1972 $5,200

J.E. Shaffer, Ph.D. Prostaglandin synthesis and cardiac adrenoceptors NIH-NHLBI Amount of Award: $28,040 Award Period: 07/01/81 - 06/30/83 T. Böke, M.D. Locally generated angiotensin and vascular neuroeffector events American Heart Association, Tennessee Affiliate Amount of Award: $14,700 Award Period: 07/01/82 - 06/30/83 Z. Qureshi. Cardiac prostaglandin synthesis NIH-HL01704 Amount of Award: $266,119 Award Period: 1985/1990 M.M. Mohy El-Din, Ph.D. Influence of vasopressin on adrenergic neurotransmission The Center for Neurosciences, University of Tennessee, Memphis Amount of Award: $8,000 Award Period: 07/01/86 - 06/30/87 M. Weis, Ph.D. Catecholamine action on cardiac prostaglandin synthesis American Heart Association, Tennessee Affiliate Amount of Award: $16,500 Award Period: 07/01/86 - 06/30/87

FELLOWSHIPS SPONSORED:


47

CURRICULUM VITAE

L. Williams, Ph.D. Influence of vasopressin on adrenergic neurotransmission American Heart Association, Tennessee Affiliate Amount of Award: $16,500 Award Period: 07/01/86 - 06/30/87 NIH-NHLBI-DEA Amount of Award: $45,000 Award Period: 04/01/87 - 03/31/89 D. Schwartz, Ph.D. Contribution of prostaglandins and adrenergically-induced Cardiac lipolysis. American Heart Association, Tennessee Affiliate. Amount of Award: $16,500 Award Period: 07/01/88 - 06/30/89 Modulation of cardiac lipolysis by prostaglandin NIH-NHLBI-DEA Amount of Award: $42,000 Award Period: 02/27/89 - 02/28/91 E. Sehic, M.D. Mechanism of action of arachidonic acid metabolites on adrenergic transmitter release Neuroscience Center of Excellence, University of Tennessee Amount of Award: $8,000 Award Period: 07/01/87 - 06/30/88 American Heart Association, Tennessee Affiliate Amount of Award: $34,000 Award Period: 07/01/89 - 06/30/91 Ruan Ying, Ph.D. Site and mechanism of regulation of cyclic AMP of beta- Adrenergic receptor stimulated prostanolid synthesis in cardiac cells. Neuroscience Center of Excellence, University of Tennessee Amount of Award: $18,000 Award Period: 07/01/92 - 06/30/93 Ruslan Damadzic, Ph.D. Mechanism of alpha-2 adrenergic receptor stimulated prostanoid synthesis Neuroscience Center of Excellence, University of Tennessee Amount of Award: $9,000 Award Period: 07/01/93 - 06/30/94 M.M. Muthalif, Ph.D. Mechanism of norepinephrine-stimulated prostaglandin synthesis. Neuroscience Center of Excellence, University of Tennessee Amount of Award: $9,000


48

CURRICULUM VITAE

Award Period: 07/01/95 - 06/30/96 Soghra Fatima, Ph.D. Mechanism of beta-adrenergic receptor-stimulated cardiac prostacyclin synthesis and its

modulation by cAMP. Neuroscience Center of Excellence, University of Tennessee Amount of Award: $9,000 Award Period: 07/01/96 - 06/30/98 M.M. Muthalif, Ph.D. Mechanism of norepinephrine-stimulated arachidonic acid release in rabbit aortic vascular smooth muscle cells. American Heart Association, Tennessee Affiliate Amount of Award: $39,216 Award Period: 07/01/96 - 06/30/98 Soghra Fatima, Ph.D. Mechanism of norepinephrine-induced translocation of cytosolic phospholipase A2 to the

nuclear envelope in rabbit vascular smooth muscle cells. American Heart Association, Tennessee Affiliate Amount of Award: $50,000 Award Period: 07/01/98 - 06/30/2000 John Parmentier, PhD. Mechanism of phospholipase D activation in norepinephrine-induced arachidonic acid

release in vascular smooth muscle cells. Neuroscience Center of Excellence, University of Tennessee, Memphis Amount of Award: $9,000 Award Period: 07/01/98 - 06/30/99 John Parmentier, PhD. Eicosanoids are mediators of norepinephrine-induced phospholipase D activation in vascular

smooth muscle cells. American Heart Association-Southern Affiliate Amount of Award: $50,000 Award Period: 07/01/99-06/30/01

Zaher Adl American Pharmacological Society – Summer Fellow Fellowship, 1996; $2,000 Jason Harper American Pharmacological Society - Summer Fellowship, 1997, $2,000 Matthew Dress American Pharmacological Society – Summer Fellow Fellowship, 1998; $2,000 Jason Harper NIH Summer Fellowship, 1998; $2,500 Gautam Gandhi American Pharmacological Society-Summer Student Fellowship, 1999, $2,500 Hassam S. Azzazy American Heart Association, Southeastern Affiliate, 1999,


49

CURRICULUM VITAE

$3,600 Mark Kinney Meadows American Heart Association, Southeastern Affiliate, 1999, $3,600 Neelima Pentapaty American Heart Association, Southeastern Affiliate, 2000, $3,600 Binh Nguyen American Pharmacological Society - Summer Student Fellowship, 2000, $2,500 Edin Basic American Pharmacological Society - Summer Student Fellowship, 2001, $2,500 Nick Newsom American Pharmacological Society-Summer Student Fellowship, 2002, $2,500 Nerma Basic American Pharmacological Society-Summer Student Fellowship, 2003

Documents

KAFAIT U. MALIK, D.Sc., Ph.D.academic.uthsc.edu/docs/fac_port_cv/KUMalik_CV_R2015.pdfKAFAIT U. MALIK, D.Sc., Ph.D. 1 CURRICULUM VITAE Mailing Address: Department of Pharmacology The