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Sigma and Sigma-Aldrich are registered trademarks belonging to Sigma-Aldrich Co. and its affiliate Sigma-Aldrich Biotechnology, L.P.

The red cube symbol is a trademark belonging to Sigma-Aldrich Co. and its affiliate Sigma-Aldrich Biotechnology, L.P.

Ingenuity is a registered trademark belonging to Ingenuity Systems.

It’s the all-new YFG. And it’s free.Think forward, work smarter with

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Go ahead, ask the big questions.Our miRNA and noncoding RNA profiling portfolio makes it possible.

The NCode™ miRNA and ncRNA systems deliver faster, more complete answers. In one powerful portfolio,

you can find answers to address your entire workflow, from sample preparation to data validation—

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2009 © Invitrogen Corporation. All rights reserved.

GE Healthcare

Coordinate your application focus.Achieve greater operational efficiency.GE Healthcare is focused on helping you develop efficient biopharmaceutical

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Learn more about operational excellence at: www.gelifesciences.com/opex

GE Healthcare Bio-Sciences AB, a General Electric CompanyBjörkgatan 30, 751 84 Uppsala, Sweden© 2008 General Electric Company – All rights reserved.

GE04-09. First printetd 09/2008.

IN A WORD, TRUST.

T4 DNA LigaseNew England Biolabs is dedicated to providing our customers with guaranteed enzyme performance. Our recombinant T4 DNA Ligase

is the most extensively used ligase for cloning experiments and other applications, including sample preparation and next generation

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technologies. For cohesive, blunt, simple or complex reactions, make T4 DNA Ligase from NEB your first choice.

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CLONING & MAPPINGDNA AMPLIFICATION

& PCRRNA ANALYSIS

PROTEIN EXPRESSION

& ANALYSIS

GENE EXPRESSION

& CELLULAR ANALYSIS

Ligation of blunt-ended HaeIII

fragments of Lambda DNA using

various amounts of T4 DNA Ligase

(400,000 cohesive end units/ml) in

a 20 µl reaction volume. Reactions

were incubated for 30 minutes

at 16°C.

0 0.1 0.2 1.0T4 DNA Ligase (µl)

0 10 20 30 60Time (min)

Ligation of HindIII fragments

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DNA using 1 cohesive end

unit (1µl of 1:400 dilution)

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were incubated at 25°C.

T4 DNA Ligase* r

Regular Concentration ................ M0202S/L

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Quick Ligation™ Kit* r ............ M2200S/L

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r = Recombinant

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New England Biolabs, Inc. is an ISO 9001 certified company

This annual international research prize recognizes

accomplishments in neurobiology research based on

methods of molecular and cell biology. The winner and

finalists are selected by a committee of independent

scientists, chaired by the Editor-in-Chief of Science.

Past winners include postdoctoral scholars and

assistant professors.

To be eligible, you must be 35 years of age or younger.

If you´re selected as this year´s winner, you will receive

$25,000, have your work published in the prestigious

journal Science and be invited to visit Eppendorf in

Hamburg, Germany.

Deadline for entries

June 15, 2009

2008 Winner

Mauro Costa-Mattioli, Ph.D.

Department of NeuroscienceBaylor College of Medicine,

Houston, Texas

Eppendorf & Science Prize for

Neurobiology

For more information

www.eppendorf.com/prize

Get recognized!

$25,000Prize

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Express proteins in hours instead of days. Referenced

in thousands of citations, Promega is the choice for

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To select the best systemfor your needs visit:www.promega.com/selectors/tnt/

One Person. One Day. Over 90,000 Genotypes.

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To explore new horizons in genotyping, visit info.appliedbiosystems.com/taqmanopenarray

Genotyping throughput that’s out of this world.The TaqMan® OpenArray™ Genotyping System Enables…

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For Research Use Only. Not for use in diagnostic procedures. Practice of the patented 5’ Nuclease Process requires a license from Applied Biosystems. The purchase of TaqMan® SNP Genotyping Assays includes an immunity fromsuit under patents specified in the product insert to use only the amount purchased for the purchaser’s own internal research when used with the separate purchase of an Authorized 5’ Nuclease Core Kit. No other patent rights areconveyed expressly, by implication, or by estoppel. For further information on purchasing licenses contact the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA. © 2009 AppliedBiosystems. All rights reserved. Applied Biosystems and AB (Design) are registered trademarks of Applied Biosystems or its subsidiaries in the US and/or certain other countries. TaqMan is a registered trademark of Roche MolecularSystems, Inc. OpenArray is a registered trademark of BioTrove, Inc.

(99r Gordon Research SiMINlRS

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New Products

LIFE SCIENCE TECHNOLOGIESAAAS/Science Business Office

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizationsare featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of anyproducts or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

113www.sciencemag.org/products SCIENCE VOL 324 3 APRIL 2009

Tissue Culture PlatesA new product line features tissue culture plates coated with a selection

of matrices that enhance cell growth and differentiation for stem

cell, cancer, cell signaling, and other research applications. Millicoat

Cultureware products are 6-well or 24-well tissue culture plates coated

with either extracellular matrix (ECM) proteins or synthetic coatings,

including collagen, fibronectin, and poly-D-lysine. ECM proteins provide

a substrate necessary for many fastidious cells to attach to a surface.

Studies show that anchorage-dependent cells growing on ECM undergo

more efficient plating, have higher proliferation rates, reach a higher

density, require lower serum and growth factor concentrations, and

demonstrate enhanced differentiation potential. ECM helps with in vitro

cell culture because it simulates aspects of the normal three-dimensional

cellular environment.

Millipore

For information 978-762-5170

www.millipore.com

Automated DispensingFill-It is a new product for rapidly dispensing cell suspensions and

other liquids into screw-cap vials, including automatically removing

and replacing vial caps. It can be coupled with Overlord 2 and the PAA

Scara robot to fully automate filling of capped vials. Fill-It enables the

rapid creation of high-quality, consistent stock vials for centralized cell-

line laboratories, screening operations, or production cell banks, and

can be used with both mammalian and microbial cell suspensions. The

integrated Scara robot allows loading of vial racks for high throughput

automation and the integration of additional instruments from the

extensive range of Overlord drivers. Overlord 2 software provides a

simple control interface that can interact with any database.

The Automation Partnership

For information +44-(0)-1252-37300

www.automationpartnership.com

Parallel Research SystemThe Synthesis 1 can be configured for parallel solid and liquid phase

synthesis as well as multiple evaporation experiments. Interchangeable

plug and play reaction blocks enable the user to quickly configure

Synthesis 1 to perform a wide range of applications. Up to 24 reaction

vessels canbeaccommodated in four separateheating zones,making the

system suitable for reaction optimization experiments. Direct, in-vessel

sample temperature feedback from each zone ensures temperature

control within 1°C. Temperatures can be set anywhere from -80°C to

160°C. Unattended operation is aided by a process timer and ability to

perform automatic ramping experiments with up to nine programmable

steps. Sample mixing is performed by frequency-controlled shaking at

speeds from 100 to 1,000 rpm. A connection for vacuum and inert gas

supply allows reactions to be run under an inert atmosphere.

Heidolph UK

For information +44-1799-513320

www.heidolph-uk.co.uk

High Throughput HPLC SystemThe ExpressHT-Ultra HPLC (high performance liquid chromatography)

system provides short cycle times and high throughput for liquid

chromatography/mass spectrometry studies of pharmacokinetics and

drugmetabolism.With cycle timesas short as60 seconds, theExpressHT-

Ultra can run six 96-well sample plates overnight. Running at a maximum

pressure of 10,000 psi, the system enables the use of small-particle

stationary phases to deliver narrow peaks to the mass spectrometer.

Featuring columns with diameters of 1 mm or smaller, the system

uses up to 95 percent less solvent per analysis than traditional HPLC

systems. Proprietary microfluidic flow control technology generates

reproducible flow rates from nanoliters per minute to hundreds of

microliters per minute.

Eksigent

For information 925-560-2628

www.eksigent.com

Molecular Modeling SoftwareFieldAlign and FieldTemplater are designed for molecular modelers

and medicinal chemists who want to discover new ligands against a

wide range of drug targets, including targets with no X-ray structural

data, such as G-coupled protein receptors. Both products accept two-

dimensional chemical sketches of compounds as inputs. The products

feature proven Field Point technology to describe molecules of interest

and suggest which molecules to make next. FieldAlign aligns molecules

to a three-dimensional field template created from an active molecule.

The molecules the user is considering synthesizing can be entered in

two dimensions. FieldTemplater finds the three-dimensional bioactive

conformation from known active compounds. Three active compounds

are all that is needed to get started.

CambridgeSoft

For information 800-315-7300

www.cambridgesoft.com

Electrophoresis SystemsTwonewgel systemsare suited for high throughput electrophoresis of polymerase chain reaction (PCR)

products from 96-well microtiter plates. The compact CSL multiSUB Midi 96 system is designed to be

used in conjunction with samples from 96-well plates to allow direct loading and easy identification

of samples. The run length between samples is 17mm. The multiSUB MIDI96 stretch has a run length

of 34 mm for extended separations. With an average run-time of just 15 to 30 minutes, the Midi 96

version allows rapid identification of samples. The eight-channel pipettes facilitate sample loading.

Two comb types are available, one with eight wells plus an additional lane for DNA markers and one

with eight wells plus two lanes for markers. Custom-made combs are also available. The buffer volume

of the Midi 96 is just 300ml, which can be reduced to 200ml by using buffer saver blocks.

Cleaver Scientific

For information +44-(0)-1788-565-300

www.cleaverscientific.com

New Products

Dr. Nubia MuñozVisiting ScientistCatalan Institute of OncologyBarcelona, Spain

�e 2009 Canada Gairdner International Awardees are:

�e Inaugural Canada Gairdner Global Health Awardee is:

“for her epidemiological studiesthat defined the essential role of thehuman papilloma virus in theetiology of cervical cancer on a globallevel which led to the developmentof successful prophylactic vaccines”

SEVEN OF THE WORLD’S LEADINGSCIENTISTS ARE RECIPIENTS OF THE2009 CANADA GAIRDNER AWARDS

50 years ago, JamesGairdner createdThe Gairdner Awardsto recognize thebreakthroughs of theworld’s leading medicalscientists and to bringthe workings of ‘highscience’ to the public.The Gairdners arenow Canada’s topinternational prize andone of the most esteemedawards in the world ofscience.

The importance of theGairdners to Canada’sfuture as a world leaderin scientific research wasunderscored when theGovernment of Canadalast year announced anendowment to increaseits awards to $100,000each and to create theworld’s first individualaward for Global Health.Starting this year, theywill benamed theCanadaGairdner InternationalAwards and the CanadaGairdner Global HealthAward.

Supported nationally by:

Gairdner WightmanAwardDr. David Sackett. MD, ScDProfessor EmeritusMcMaster UniversityHamilton, OntarioCanada

“for his leadership in the fields ofclinical epidemiology and evidence-based medicine, which have hadmajor impacts internationally inapplied clinical research and inthe practice of medicine”

Dr. Shinya YamanakaProfessor, Department of Stem Cell BiologyInstitute for Frontier Medical SciencesDirector, Centre for iPS Cell Research andApplicationsInstitute for Integrated Cell-Material SciencesKyoto UniversityJapan

“for his demonstration that thekey transcription factors whichspecify pluripotency may becomereprogrammed somatic cells topluripotent stem cells”

Dr. Kazutoshi MoriProfessor, Department of BiophysicsGraduate School of ScienceKyoto UniversityJapan

Dr. Peter WalterHoward Hughes Medical InstituteDepartment of Biochemistry and BiophysicsUniversity of California, San FransicsoSan Francisco, CA

“for their dissection and elucidationof a key pathway in the unfoldedprotein response which regulatesprotein folding in the cell”

Dr. Richard LosickMaria Moors Cabot Professor of BiologyHoward Hughes Medical Institute ProfessorFaculty of Arts and SciencesHarvard UniversityCambridge, MA

Dr. Lucy ShapiroD.K. Ludwig ProfessorDepartment of Developmental BiologyDirector, Beckman Center for Molecular andGenetic MedicineStanford University School of MedicineStanford, CA

“for their discovery of mechanismsthat define cell polarity andasymmetric cell division, processeskey in cell differentiation and inthe generation of cell diversity”

www.gairdner.org

R&D Systems Tools for Cell Biology Research™

USA & Canada R&D Systems, Inc. Tel: (800) 343-7475 info@RnDSystems.com

Europe R&D Systems Europe, Ltd. Tel: +44 (0)1235 529449 info@RnDSystems.co.uk

Selection expanding weekly—visitwww.RnDSystems.com/go/request to sign up for weekly new product updates.

For details about the images above, please visit our website at www.RnDSystems.com/go/AntibodyAd

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