José M. Ordovás - University of Massachusetts Lowell · José M. Ordovás, PhD, (born in Zaragoza, Spain in 1956) is Professor of Nutrition and a Senior Scientist at the USDA-Human

José M. Ordovás

Nutrition and Genetics Professor Director of the Nutrition and Genomics Laboratory JM-USDA-Human Nutrición Research Center and School of Nutrition Science and Policy, Tufts University, Boston, MA USA

José M. Ordovás, PhD, (born in Zaragoza, Spain in 1956) is Professor of Nutrition and a Senior Scientist at the USDA-Human Nutrition Research Center on Aging at Tufts University in Boston, Massachusetts where he also is the Director of the Nutrition and Genomics Laboratory. He is a Senior Collaborating Scientist at the CNIC, Madrid,

Dr. Ordovas was educated in Spain at the University of Zaragoza where he completed his undergraduate work in chemistry (1978) and received his doctorate in the topic of Human Lipoprotein Metabolism (1982). He did postdoctoral work at the MIT, Harvard and Tufts.

Dr. Ordovas’ major research interests focus on the genetic factors predisposing to cardiovascular disease and obesity and their interaction with the environment and behavioral factors with special emphasis on diet. He has published more than 740 scientific articles in peer review journals and written numerous reviews and books on these topics. In this regard, he is considered one of the most distinguished world experts in gene-diet interactions related to cardiovascular traits. Moreover, he has trained in his laboratory over 60 scientists and his current genetic studies involve populations and investigators from all Continents.

Throughout his career, Dr. Ordovas has received multiple honors for his scientific achievements including, among several others, the USDA Secretary’s Award, the Centrum American Nutrition Society Award; the Mary Swartz Award from the Dietetic Association; the Garry-Labbe Award from the American Association for Clinical Chemistry, the Francisco Grande Memorial Lecture all for Excellence in Nutrition Research; The Rafael del Pino Foundation Lecture, the Turkish Genetics Society Award; the Jaén Paraíso Interior and AEMO awards for his contributions to the diffusion of the Mediterranean diet and the Olive oil; the Good Cholesterol award from Aviles and the Danone Foundation Award for achievements in Nutrition Research and Gold Medal of the Spanish Society of Cardiology and the Francisco Grande Award from the Fundacion Dieta Meditarranea. He has been awarded an honorary degree in Medicine bestowed by the University of Cordoba in Spain and the title of Member of the Royal Academies of Sciences, Medicine, Nutrition and Pharmacy, all of them in Spain.

Dr. Ordovas serves on multiple editorial boards and is active with multiple international peer review and steering committees and advisory boards.

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CURRICULUM VITAE

NAME: Jose M. Ordovas

DATE OF BIRTH: June, 17, 1956

BIRTHPLACE: Zaragoza, Spain

EDUCATION: 1978 B.Sc. (Chemistry) University of Zaragoza (Spain)

1979 M.Sc. (Biochemistry) Univ. of Zaragoza (Spain)

1982 Ph.D. (Biochemistry) Univ. of Zaragoza (Spain)

POSITIONS HELD

1978 - 1982 Teaching Assistant Department of Biochemistry and Nutrition. University of

Zaragoza (Spain).

1982 - 1983 Research Associate, Dept. of Nutrition and Food Science. Massachusetts

Institute of Technology (MIT).

1983 - 1984 Research Associate, Dept. of Cardiology, Children's Hospital, Harvard Medical

School.

1984 - 1985 Research Associate and Dana Research Fellow.

Lipid Metabolism Laboratory, USDA Human Nutrition Research Center on Aging

at Tufts University.

1985 - 1986 Scientist III. Lipid Metabolism Laboratory. USDA HNRC at Tufts University.

1986 - 1991 Assistant Professor of Nutrition, Scientist II, USDA HNRC at Tufts University.

1991 - 1998 Associate Professor of Nutrition, Scientist I, USDA HNRC at Tufts University.

Head of Molecular Biology Section, Lipid Metabolism Laboratory.

Professor of Nutrition, Friedman School of Nutrition Science and Policy at Tufts

University.

2000 - Professor of Genetics, Sackler School of Biomedical Sciences.

2001 - Director of Nutrition and Genomics Laboratory, USDA HNRC at Tufts University.

2004 - 2006 Director of the Cellular and Molecular Nutrition Program at the Friedman School

of Nutrition Science and Policy at Tufts University.

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OTHER PROFESSIONAL ACTIVITIES, HONORS AND AWARDS

PROFESSIONAL ACTIVITIES

Nutrition Expert consultant for Mexico and Central America, American Soybean

Association (1995-1996).

President of the International Conference on the Health Effects of omega3

Polyunsaturated fatty Acids, Granada, Spain (1995)

President of the Nutrition Symposium. Latin-American Society of Atherosclerosis.

Cancun, Mexico (1997)

Director of the Course “The impact of lipids on cardiovascular disease”. Spanish Society

of Atherosclerosis/American Heart Association (1998-1999)

Visiting Professor, University of Costa Rica. (1997-1999)

Visiting Professor, University of Cordoba, Spain (several occasions)

Visiting Professor, University of Zaragoza, Spain (several occasions)

Guess Professor, Zhejiang University, People’s Republic of China (2009)

Director of the Nutrition Course “Grande Covian”, Universidad Internacional Menendez

Pelayo, Santander (2000)

Organizer and Director Conference series “Living-well-to-100” (2007-2009).

Expert Consultant to the Singapore Ministry of Health (2000)

Member Scientific Advisory Board for Perlegen Sciences, Inc. Mountain View, CA (2000-

2006)

Member Scientific Advisory Board for Interleukin Genetics, Inc. Waltham, MA (2000-

Present)

Member of the LSRO committee on Nutritional Genomics (2001-2002)

Member of the Nutrigenomics Organization (NUGO) 2005-Present

Secretary of the International Society of Nutrigenetics and Nutrigenomics (2008-2010)

External Scientific advisory committee for LIPGENE (2007-2010)

External Scientific Advisory Committee for the UC Davis National Center for Health

Disparities (2007-2009)

Scientific Advisory Board for the California Avocado Comission. (2007-2009)

Scientific Advisor International Olive Oil Council (1995-2000)

Member Scientific Committee Fundación Española de la Nutrición (FEN) (2010-Present)

Member of the Institute of Medicine’s Committee on Health Benefits of Fish of the

National Academies (2006-2009)

Member of the Food and Nutrition Board, the National Academy of Sciences (2005-

2011)

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Member of the Steering Committee of PHENX (National Human Genome Research

Institute) (2008-Present)

Member of the Scientific Advisory Board for the Banco Nacional de DNA, Spain (2008-

Present)

Member of the ARIC Observational Study Monitoring Board (2008-Present)

Member of the Expert Scientific Panel of the Genes, Environment, and Health Initiative’s

(GEI’s) genome-wide Association program, GENEVA. National Human Genome

AResearch Institute (2008-Present)

Member of the IMIBIC Scientific Advisory Panel (2010-Present)

President of the CIBERDEM External Advisory Panel (2009-Present)

President of the Board of Trustees of the Instituto Madrileno de Estudios Avanzados en

Alimentacion (IMDEA) (2007-2011)

President of the Scientific Advisory Board and Board of Trustees of IMDEA, Spain (2007-

2011 )

President Scientific Committee Centro de Investigación de Tecnología Agroalimentaria

del Gobierno de Aragón, Soain (2007-Present)

Member of the Scientific Advisory Committee of the Institute of Health Sciences of

Aragon, Spain

Member Scientific Advisory Board of the UK Medical Research Council Centre in Brain

Ageing and Vitality (2008)

Member Scientific Advisory Board Food and Drug Administration, USA (2008-Present)

Member of the Scientific Committee of the IMIBIC Center of Excellence (Spain)

Member of the Scientific Committee of the Spanish Centre for Aging Research.

Chair Elect, Nutrient-Gene Interactions Research Interest Section, American Society for Nutrition

Associate Editor Advances in Nutrition

HONORS

Francisco Grande Memorial Lecture, Sociedad Espanola de Arteriosclerosis (1998)

Mary Swartz Rose Lecture Memorial from the Greater New York Dietetic Asssociation

for Excellence in Nutrition (2007)

Fundacion del Pino Lecturer (2007)

Member of the Royal Academy of Sciences. Zaragoza, Spain (2008)

Honorary Degree in Medicine. University of Cordoba, Spain (2008)

Fundacion del Pino Lecturer (2010)

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Member of Honor, Royal Academy of Medicine. Zaragoza, Spain (2010)

Member Spanish Academy of Nutrition (2010)

Member Spanish Royal Academy of Pharmacy (2011)

Member of the Royal Academy of Medicine (Murcia, Spain, 2012)

Chair-Elect of the NGI-RIS. ASN

AWARDS

Outstanding Research Awards for Research in Genomics, Lipoproteins and Nutrition

(2002)

Jaén Paraíso Interior award for his contributions to the diffusion of the Mediterranean

diet and the Olive oil (2005)

AEMO Award for Excellent in Nutrition research related with the Olive Oil (2006)

Turkish Genetics Society for his contributions to the development of Nutrigenomics

(2005)

USDA Secretary’s award (the highest award within the United States Department of

Agriculture). "his work has significantly advanced the emerging field of nutritional

genomics and provided a foundation for developing targeted dietary and lifestyle

recommendations for given populations based on genetics" (2006)

The American Association for Clinical Chemistry Award (2006)

Centrum Award from the American Society of Nutrition "for recent investigative

contributions of contemporary significance to the understanding of human nutrition"

(2007)

Good Cholesterol Award (Aviles, Spain) (2008)

AACC Nutrition Division Garry Labbe Award (2008)

Danone Institute Award to the Scientific Trajectory in Nutrition Research (2008)

Gold Medal of the Spanish Society of Cardiology (2009)

Grande Covian Award, Sociedad Espanola de Nutricion Basica y Aplicada (2009)

Distinguished Faculty Award, Tufts University (2009)

Gregorio Varela Award for excellence in Nutrition Research (2010)

University of Navarra Food and Nutrition International Award (2010)

The Panamerican Nutrition and Food Research Award (2011)

Gregorio Maranon Nutrition Award, Real Academia Espanola de Gastronomia (2011)

Jose Mataix Nutrition Award, Academia Nacional de Nutricion (2011)

Grand Prix de la Science de l'Alimentation awarded to an Institution or to a Person

responsible for contributing to the progress of Food Sciences at an international level

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(2011)

Grande Covian Award, Fundacion Dieta Mediterranea (2012)

Hypocrates award for innovative research in Medicine (2013)

Merck Serono Award for research related to micro-RNAs in Nutrition (2013)

Dr. Benapres Award (2013)

Maimonides Memorial Lecture (2015)

Grand Prix de la Science de l'Alimentation (2016)

NAOS Strategy award, for the advancements in Nutrition and Genetics (2016)

OTHER ACADEMIC ACTIVITIES

During the last 10 years I have had 14 Ph.D. students and I have hosted in my laboratory over

60 foreign visiting scientists and graduate students to do research related to nutrition,

lipoprotein metabolism, obesity, genetics and bioinformatics.

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INTERNATIONAL LECTURES During the last five years I have participated as invited speaker in over 200 International

Congresses, courses, and symposiums in Europe, Asia, Central and South America and the USA.

The topics of these lectures have focused primarily on dietary prevention and treatment of

cardiovascular disease, Mediterranean diet, the cultural transition in the Asian Pacific region

and the interaction between genetics and the environment as a determinant of individual

health risk, and the genetics of cardiovascular disease.

PROFESSIONAL MEMBERSHIPS

Member of the Arteriosclerosis and Nutrition Councils, American Heart Association

Member of the Spanish Society of Atherosclerosis

Member of the European Lipoprotein Club

Member of the European Atherosclerosis Society

Member of the International Society of Atherosclerosis

Member of the American Association for Clinical Chemistry

Member of the Australian Atherosclerosis Society

Member of the American Society of Human Genetics

Member of the American Society for Nutrition.

EDITORIAL ACTIVITIES

Associate Editor of Atherosclerosis until 2002, then member of the Editorial Board

through 2005

Associate Editor of Nutrition, Metabolism and Cardiovascular Disease

Editorial Board Nutrition Reviews

Editorial Board Clinical Investigation in Arteriosclerosis

Editorial Board Fats and Oils, an International Journal

Editorial Board Cardiovascular Drugs and Therapy

Editor Current Opinion in Lipidology, Molecular Biology Section

Editor Current Cardiovascular Risk Reports Lipids Section

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Editorial Board Cardiovascular Drugs and Therapy

Associate Editor of Nutrition, Metabolism and Cardiovascular Disease

Consulting Editor American Journal Clinical Nutrition

Editorial Board Journal of Lipid Research

Editorial Board Nutrition and Genes

Associate Editor Advances in Nutrition

Frequent reviewer for the following Journals: New England Journal of Medicine, Lancet,

Circulation, Arteriosclerosis; Thrombosis and Vascular Biology; Journal of Lipid Research;

Journal of Nutrition; Nutrition Research; American Journal of Clinical Nutrition;

American Journal of Human Genetics; Human Genetics; Clinical Genetics and the British

Medical Journal among many others.

PEER REVIEW COMMITTEES

American Heart Association peer review committee 1992-1995, 2003-2007

Member Expert Panel on Genetic Research NHLBI-NIH

Consultant NHLBI Special Emphasis Panel on Animal Studies and Atherosclerosis

Consultant NHLBI Special Emphasis Panel on Epidemiological Studies

Other NIDDK, NIA, NHGRI and NHLBI Study Sections

Member, Program Projects Parent Committee, NHLBI 2003-2007

Expert Reviewer European Union Commission

Chartered member of the NHLBI CASE Study Section 2007-2012

Reviewer for National Programs for The Netherlands, Italy, Switzerland, Austria, Qatar,

Spain and the UK.

RESEARCH INTERESTS

Dr. Ordovas’ major research interests focus on the genetics factors predisposing to

cardiovascular disease and obesity and their interaction with the environment and behavioral

factors with special emphasis on diet. He has participated for almost twenty years in the

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Framingham Heart Study and he is carrying out multiple cross-cultural studies to determine

cardiovascular risk in different populations around the world, with special interest in the Asian

Pacific and the Mediterranean regions.

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CURRENT RESEARCH FUNDING

United States Department of Agriculture

National Heart Lung and Blood Institute

National Institutes of Aging

National Institute of Diabetes and Digestive and Kidney Diseases

EU SEVENTH FRAMEWORK PROGRAMME

PUBLICATIONS

Dr. Ordovas has published over 700 scientific articles in peer review journals, including Nature,

Nature Genetics, The Lancet, the New England Journal of Medicine, Science, JAMA, Circulation,

Arteriosclerosis Thrombosis and Vascular Biology, Journal of Biological Chemistry, Proceedings

of the National Society of Sciences (USA) and the American Journal of Clinical Nutrition.(see list

attached)

Moreover, Dr. Ordovas has written numerous reviews on the topic of diet and coronary heart

disease, diet and genetics, and the pathophysiology of arteriosclerosis. Dr. Ordovas has also

published 4 books on those topics. The h index is 110 according to Google Academic

PUBLICATIONS

1. Sevilla MC, Ordovas JM, and Grande F. Distribution of cholesterol in human cord plasma.

Ann. Pediatr. 14:233-238, 1981.

2. Pocovi,M, Ordovas JM, and Grande F. Cholesterol esterification in human plasma. Rev.

Esp. Fisiol. 38:209-219, 1982.

3. Pocovi M, Ordovas JM, and Grande F. LCAT, lipids and lipoproteins in maternal and

umbilical cord plasma. Artery 11:264-272, 1983.

4. Sevilla MC, Ordovas JM, and Grande F. Cholesterol concentration and distribution in

Spanish newborns. Handbook of Electrophoresis and Lipoproteins Vol III, LE Lewis, Ed.

CRC Press, 179-183, 1983.

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5. Ordovas JM, Pocovi M, and Grande F. Plasma lipids and cholesterol esterification rate

during pregnancy. Obstet. and Gynecol. 63:20-25, 1984.

6. Pocovi M, Ordovas JM, and Grande F. Distribution of apolipoproteins A-I and B during

pregnancy. Rev. Esp. Fisiol. 40:183-190, 1984.

7. Hellerstein MK, Sasak V, Ordovas JM, and Munro HN. Isolation of alpha-1-acid

glycoprotein from human serum using high performance liquid chromatography. Anal.

Biochem. 146:366-371, 1985.

8. Libby P, Miao P, Ordovas JM, and Schaefer EJ. Effect of lipoproteins on mitogen

stimulated growth of arterial smooth muscle cells. J. Cell. Physiol. 124:1-8, 1985.

9. Zannis VI, Ordovas JM, Cladaras C, Cole FS, and Schaefer EJ. mRNA and apoE synthesis

abnormalities in peripheral blood monocyte-macrophages in familial apolipoprotein E

deficiency. J. Biol. Chem. 260:12891-12894, 1985.

10. Schaefer EJ, Ordovas JM, Law SW, Ghiselli G, Kashyap ML, Srivastava LS, Heaton WH,

Albers JJ, Connor WE, Lindgren FT, Lemeshev Y, Segrest JP, and Brewer HB Jr. Familial

apolipoprotein A-I and C-III deficiency, variant II. J. Lipid Res. 26:1089-1101, 1985.

11. Sasak W, Ordovas JM, Elbein A, and Berninger R. Castanospermine inhibits

glucosidases I and glycoprotein secretion in human hepatoma cells. Biochem. J.

232:759-766, 1985.

12. Ordovas JM, Schaefer EJ, Salem D, Ward R, Glueck CJ, Vergani C, Wilson P, and

Karathanasis SK. Apolipoprotein A-I gene polymorphism associated with premature

coronary artery disease and familial hypoalphalipoproteinemia. New Engl. J. Med.

314:671-677, 1986.

13. Schaefer EJ, and Ordovas JM. Metabolism of apolipoprotein A-I, A-II, and A-IV. In:

Methods in Enzymology, Plasma lipoproteins, Part B: Caracterization, Cell Biology and

Metabolism. Vol. 129, Albers JJ and Segrest J Ed. Academic Press, 420-443, 1986.

14. Schaefer EJ, McNamara JR, Mitri CJ, and Ordovas JM. Genetic high density lipoprotein

deficiency states in Atherosclerosis VII. N.H. Fidge, P. Nestel, ed. Excerpta Medica,

Amsterdam, 183-186, 1986.

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15. Libby P, Ordovas JM, Auger KR, Robbins AH, Birinyi LK, Dinarello CA. Endotoxin and

tumor necrosis factor induce interleukin-I gene expression in adult human vascular

endothelial cells. Am. J. Pathol. 124:179-186, 1986.

16. Haddad IA, Ordovas JM, Fitzpatrick T, Karathanasis SK. Linkage, evolution and

expression of the rat apolipoprotein A-I, C-III and A-IV genes. J. Biol. Chem.

261:13268-13277, 1986.

17. Schaefer EJ, Gregg RE, Ghiselli G, Forte TM, Ordovas JM, Zech LA, and Brewer HB Jr.

Familial apolipoprotein E deficiency. J. Clin. Invest. 78:1206-1219, 1986.

18. Libby P, Ordovas JM, Birinyi LK, Auger KR, Dinarello CA. Inducible Interleukin-I gene

expression in human vascular smooth muscle cells. J. Clin. Invest. 78:1432-1438, 1986.

19. Schaefer EJ, McNamara JR, Mitri CJ, Ordovas JM. Genetic high density lipoprotein

deficiency and atherosclerosis. Angel A.,Frohlich J., ed. Lipoprotein Deficiency

Syndromes. Adv. Exp. Biol. Med. 201:1-15, 1986.

20. Ordovas JM, Litwack-Klein LE, Wilson PWF, Schaefer EJ. Apolipoprotein E isoform

phenotyping methodology and population frequency with identification of apoE1 and

apoE5 isoforms. J. Lipid Res. 28:371-380, 1987.

21. Hughes T, Sasak WV, Ordovas JM, Forte TM, Lamon-Fava S, and Schaefer EJ. A novel

cell line (Caco-2) for the study of intestinal lipoprotein synthesis. J. Biol. Chem.

262:3762-3767, 1987.

22. Lamon-Fava S., Ordovas, JM, Mandel, G., Forte, TM, Goodman, RH, and Schaefer, EJ.

Secretion of apolipoprotein A-I in lipoprotein particles following transfection of the

human apolipoprotein A-I gene into 3T3 cells. J. Biol. Chem. 262:8944-8947, 1987.

23. Ordovas JM, Peterson JP, Santaniello P, Cohn J, Wilson PWF, and Schaefer EJ. Enzyme

linked immunosorbent assay for human plasma apolipoprotein B. J. Lipid Res.

28:1216-1224, 1987.

24. McNamara JR, Campos H, Ordovas JM, Peterson J, Wilson PWF and Schaefer, E.J.

Effect of gender, age and lipid status on low density lipoprotein subfraction distribution:

results from the Framingham Offspring Study. Arteriosclerosis 7:483-490, 1987.

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25. Prioli RP, Ordovas JM, Rosenberg I, Schaefer EJ, Pereira MEA. Similarity of cruzin an

inhibitor of Trypanosoma cruzi neuraminidase, to high density lipoprotein. Science

238:1417-1419, 1987.

26. Ordovas JM, and Schaefer EJ. Coronary artery disease, lipid disorders and genetic

polymorphisms. Ann. Biol. Clin. 46:24-29, 1988.

27. Hughes T, Ordovas JM, and Schaefer EJ. Regulation of apolipoprotein B synthesis and

secretion by Caco-2 cells. lack of fatty acid effects and control by intracellular calcium

ion. J. Biol. Chem. 263:3425-3431, 1988.

28. McNamara JR, Campos H, Ordovas JM, Wilson PWF, and Schaefer EJ. Gradient gel

electrophoretic analysis of low density lipoproteins. Am. Biotech. Lab. 6:1-4, 1988.

29. Cohn JS, McNamara JR, Ordovas JM, and Schaefer EJ. Postprandial plasma lipoprotein

changes in human subjects of different ages. J. Lipid. Res. 29:469-478, 1988.

30. Cohn JS, McNamara, Cohn SD, Ordovas JM, and Schaefer EJ. Plasma apolipoprotein

changes in the trygliceride-rich lipoprotein fraction of human subjects fed a fat-rich

meal. J.Lipid Res. 29:925-936, 1988.

31. Campos H, McNamara JR, Ordovas JM, and Schaefer EJ. Diferences in low density

lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal

women. J. Clin. Endocr. Metab. 67:30-35, 1988.

32. Schaefer EJ, McNamara JR, Genest J, and Ordovas JM. Clinical significance of

hypertriglyceridemia. Sem. Thrombosis and Hemostasis 14:143-148, 1988.

33. Schaefer EJ, and Ordovas JM. Hypoalphalipoproteinemia. Encyclopedia of Birth

Defects.

34. Schaefer EJ, and Ordovas JM. Apolipoprotein A-I and C-III deficiency states.

Encyclopedia of Birth Defects.

35. Schaefer EJ, McNamara JR, and Ordovas JM. Lipoprotein abnormalities in Premature

Coronary Artery Disease. Atherosclerosis Reviews. R.I.Levy ed. 17:21-27, 1988.

36. Schaefer EJ, McNamara JR, Genest J, and Ordovas JM. Genetics and abnormalities of

plasma lipoproteins. Clin. Chem. 34:B9-B12, 1988.

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37. Genest J, Ordovas JM, Robbins AH, King DC, Frossard PM, and Schaefer EJ. RsaI RFLP of

the human apolipoprotein B gene: RS1 and Rs2. Nucleic Acid Res. 16:8746, 1988.

38. Genest J, Ordovas JM, Robbins AH, King DC, Frossard PM, and Schaefer EJ. RsaI RFLP of

the human apolipoprotein B gene: RS3 and RS4. Nucleic Acid Res. 16:8747, 1988.

39. Ordovas JM, King DC, and Schaefer EJ. Genetic HDL Deficiency States. Eicosanoids

apolipoproteins, lipoprotein particles and atherosclerosis. Malmendier ed. Advances in

Experimental Medicine and Biology 243:61-66, Plenum Press, 1988.

40. Ordovas JM, King DC, and Schaefer EJ. Familial apolipoprotein A-I, C-III and A-IV

deficiency. Human apolipoprotein mutants: from Gene Structure to phenotypic

expression. Sirtori C., Franceschini, G; Brewer, H.B. and Assmann, G. ed. Plenum Press.

Pp. 157-161, 1989.

41. Lamon-Fava S, Fisher EC, Nelson ME, Evans WJ, Millar JS, Ordovas JM, Schaefer EJ.

Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein

particle size, and apolipoproteins. J. Clin Endocr. Metab. 68:17-21, 1989.

42. McNamara JR, Campos H, Adolphson JL, Ordovas JM, Wilson, PWF, Albers, JJ, Usher,

DG, and Schaefer EJ. Screening for lipoprotein(a) elevations in plasma ans assessment

of size heterogeneity using gradient gel electrophoresis. J. Lipid Res. 30:747-755, 1989.

43. Civeira F, Cassidy DK, Schaefer EJ, and Ordovas JM. Three different insertion

polymorphism 3' to the human apolipoprotein A-IV gene. Nucleic Acids Res. 17:6428,

1989.

44. Ordovas JM, Cassidy DK, Civeira F, Bisgaier CL, and Schaefer EJ. Familial

apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to a

deletion of a gene complex on chromosome 11. J. Biol. Chem. 264:16339-16342, 1989.

45. Schaefer EJ, McNamara JR, Genest JJ, and Ordovas JM. Genetic high density

lipoprotein deficiency. In NE Miller, ed. High density lipoproteins and atherosclerosis II.

Excerpta Medica, Amsterdam, 1989; pp.79-86.

46. 46 Pocovi M, Civeira F, Jimenez D, Gonzalez J, Garces C, Cia P, and Ordovas JM.

Anormalidades lipidicas en familias con prevalencia de enfermedad coronaria

prematura. Clin. Invest. Arteriosclerosis 1:143-147, 1989.

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47. Stucchi AF, Ordovas JM, Shwaery GT, and Smith SC. Comparative molecular properties

of swine and human very low density lipoprotein - apolipoproteins E and C. Comp.

Biochem. Physiol. 96B:209-214, 1990.

48. Genest JJ, Ordovas JM, Robbins AM, Salem DN, Wilson PWF, Masherani U, Frossard

PM, Meade T, Cohn S, and Schaefer EJ. DNA polymorphisms of the apolipoprotein B

gene in patients with premature coronary artery disease. Atherosclerosis 82:7-17, 1990.

49. Ordovas, J.M., Civeira, F., Genest, J., and Schaefer, E.J. Genetic High Density

Lipoprotein Deficiency States. In Atherosclerosis Reviews. Biotechnology of

Dyslipoproteinemias. Application in Diagnosis and Control. C. Lenfant, A. Albertini, R.

Paoletti, and A. Catapano. Volume 20, pp. 261-274. Raven Press, 1990.

50. Campos H, Wilson PWF, Jimenez D, McNamara JR, Ordovas JM, and Schaefer EJ.

Differences in apolipoproteins and low density lipoprotein subfractions in

postmenopausal women on and off estrogen therapy: results from the Framingham

Offspring Study. Metabolism 39:1033-1038, 1990.

51. Genest JJ, McNamara JR, Ordovas JM, Martin-Munley S, Jenner JL, Millar J, Salem DN,

and Schaefer EJ. Effect of elective hospitalization on plasma lipoprotein cholesterol and

apolipoprotein A-I, B, and Lp(a). Am. J. Cardiol. 65:677-679, 1990.

52. Moreda, A., Alamillo, J.A., Pocovi, M., Civeira, F, Blasco, M., and J.M. Ordovas. Niveles

de colesterol y trigliceridos, y distribucion de cholesterol en lipoproteinas en una

poblacion laboral espanola. Clin. Invest. Arteriosclerosis, 1990.

53. Crespo, P., Gonzalez, C., Ordovas, J.M., Ortiz, J.M., Rodriguez, J.C., and Leon, J.

Induction of apolipoprotein E gene expression in human and experimental

atherosclerotic lessions. Biochem. Biophys. Res. Comm. 168, 733-740, 1990.

54. Lichtenstein, A.H., Cohn, J.S., Hachey, D.L.K., Millar, J.S., Ordovas, J.M., and Schaefer,

E.J. Comparison of Deuterated Leucine, Valine and Lysine in the measurement of human

Apolipoprotein A-I and B Kinetics. J. Lipid Res. 31:1693-1701, 1990.

55. Ordovas, J.M., Apolipoprotein Polymorphisms. Current Opinions in Lipidology 1:514-

18, 1990.

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56. Ordovas, J.M., Molecular Biological Approaches to the Understanding of Lipoprotein

Metabolism. In Medical, Chemical and Biochemical Aspects of Antilipidemic Drugs.

Witiak et al. eds. Elsevier. pp. 97-121, 1991.

57. Ordovas, J.M., Civeira, F., Genest, J., Craig, S., Robbins, A.H., Meade, T., Pocovi, M.,

Frossard, P.M., Masharani, U., Wilson, P.W.F., Salem, D.N., Ward, R.H., and Schaefer E.J.

Restriction Fragment Length Polymorphisms of the apoliprotein A-I, C-III, A-IV gene

locus: Relationships with lipids, apoliproteins and premature coronary artery disease.

Atherosclerosis 87:75-86, 1991.

58. Campos H, Willet WC, Peterson RM, Siles X, Bailey SM, Wilson PWF, Posner BM,

Ordovas JM, Schaefer EJ. Nutrient intake comparisons between Framingham and rural

and urban Puriscal, Costa Rica: associations with lipoproteins, apolipoproteins, and LDL

particle size. Arteriosclerosis and Thombosis 11:1089-1099, 1991.

59. Campos H, Bailey, SM, Gussak LS, Siles X, Ordovas JM, Schaefer EJ. Relationships of

body habitus, fitness levels and cardiovascular risk factors including lipoproteins and

apolipoproteins in a rural and urban Costa Rican population. Arteriosclerosis and

Thombosis 11:1077-1088, 1991.

60. Genest, J.J., Martin-Munley, S.S., McNamara, J.R., Ordovas, J.M., Silberman, S.R.,

Wilson, P.W.F., Schaefer, E.J. Prevalence of lipoprotein(a) excess in coronary heart

disease. Am. J. Cardiol. 67:1039-1145, 1991.

61. Lamon-Fava S, Jimenez D, Christian JC, Ordovas JM, Schaefer EJ. The NHLBI Twin

Study: Heritability of apolipoprotein A-I, B and low density lipoprotein subclasses and

concordance for Lp(a). Atherosclerosis 91, 97-106, 1991.

62. Ordovas J.M., F. Civeira, C. Garces, M. Pocovi. Genetic variation at the apoA-I, C-III, A-

IV gene complex: A critical review of the associations between the PstI and the SstI

RFLPs at this locus with lipid disorders. In: DNA Polymorphisms as Disease Markers. D.J.

Galton editor. Plenum Press. pp 91-105, 1991

63. Genest JJ, McNamara JR, Upson B, Salem DN, Ordovas JM, Schaefer EJ, Malinow MR.

Prevalence of Familial hypercysteinemia in men with premature coronary artery

disease. Arteriosclerosis and Thrombosis 11:1129-1136, 1991.

16

64. Lopez-Miranda J, Perez-Jimenez F, Torres A, Espino-Montoro A, Gomez P, Hidalgo-

Rojas L, Ordovas JM, Jimenez-Pereperez JA. Effect of cyclosporin on plasma lipoproteins

in bone marrow transplantation patients. Clin.Biochem. 25:379-386, 1992.

65. Genest JJ, Bard JM, Fruchart JC, Jenner JL, Ordovas JM, Wilson PWF, Salem DN,

Schaefer EJ. Plasma apolipoproteins (a), A-I, A-II, B, E, and C-III containing particles in

men with premature coronary artery disease. Arteriosclerosis 90:149-157, 1991.

66. Stucchi AF, Hennessy LK, Vespa DB, Weiner EJ, Osada J, Ordovas JM, Schaefer EJ,

Nicolosi RJ. Effect of corn and coconut oil-containing diets with and without cholesterol

on high density lipoprotein apoprotein A-I metabolism and hepatic mRNA levels in

Cebus monkeys. Arteriosclerosis and Thrombosis 11:1719-1729, 1991.

67. Osada, J., Fernandez-Sanchez, A., Diaz-Morillo, J.L., Aylagas, H., Miro-Obradors, M.J.,

Ordovas, J.M. and Palacios-Alaiz, E. Hepatic expression of apolipoprotein A-I gene in rats

is upregulated by monounsaturated fatty acid diet. Biochem. Biophys. Res. Commun.

180:162-168, 1991.

68. Campos H, Genest JJ, Blijlevens E, McNamara JR, Jenner J, Ordovas JM, Wilson PWF,

Schaefer EJ. Low density lipoprotein particle size and coronary artery disease.

Arteriosclerosis and Thrombosis 12:187-195, 1992.

69. Campos, H., Blijlevans, E., McNamara, J.R., Ordovas, J.M., Posner, B.M., Wilson, P.W.F.,

Castelli, W.P., Schaefer, E.J. LDL particle size distribution: Results from the Framingham

Offspring Study. Arterioscler. Thromb. 12:1410-1419, 1992.

70. Campos H, Siles X, Vives M, Ordovas JM, Mata L, Schaefer EJ. Prevalence of

cardiovascular risk factors in rural and urban Puriscal, Costa Rica. Circulation 85:648-

658, 1992.

71. Civeira F, Genest J, Pocovi M, Salem DN, Herbert PN, Wilson PWF, Schaefer EJ, and

Ordovas JM. The MspI restriction fragment length polymorphism 3' to the

apolipoprotein A-II gene: relationships with lipids, apolipoproteins, and premature

coronary artery disease. Atherosclerosis 92:165-176, 1992.

72. Crespo P, Ordovas JM, Albajar M, Rodriguez JC, Ortiz, JM, Leon J.

Hypercholesterolemia induces differential expression of rabbit apolipoprotein A and C

genes. Atherosclerosis 95:95-103, 1992.

17

73. Crespo, P., Angeles Ros, M., Ordovas, J.M., Rodriguez, J.C., Ortiz, J.M., Leon, J. Foam

cells from aorta and spleen overespress apolipoprotein E in the absence of

hypercholesterolemia. Biochem. Biophys. Res. Commun. 183:514-523, 1992.

74. Genest, J.J., J.R. McNamara, J.M. Ordovas, J.L. Jenner, J.S. Millar, S.R. Silberman, K.M.

Anderson, P.W.F. Wilson, D.N. Salem, E.J. Schaefer. Prevalence of lipoprotein

cholesterol and apolipoprotein A-I, B and Lp(a) abnormalities in men with premature

coronary artery disease. J Am Coll Cardiol 19:792-802, 1992.

75. Genest, J.J., S. Martin-Munley, J.R. McNamara, J.M. Ordovas, J. Jenner, R. Myers,

P.W.F. Wilson, E.J. Schaefer. Prevalence of familial lipoprotein disorders in patients with

premature coronary artery disease. Circulation 85:2025-2033, 1992.

76. Hennessy LK, Osada J, Ordovas JM, Nicolosi RJ, Brousseau ME, Schaefer EJ. Effects of

dietary fatty acids and cholesterol on liver lipid content and hepatic apolipoprotein A-I,

B and E and LDL receptor mRNA levels in Cebus monkeys. J. Lipid Res. 33:351-360, 1992.

77. Genest, J.J., Jenner, J., McNamara, J.R., Ordovas, J.M., Silberman, S.R., Wilson, P.W.F.,

Schaefer, E.J. Prevalence of lipoprotein(a) [Lp(a)] excess in coronary artery disease.

American Journal of Cardiology 67:1039-1145, 1991.

78. Mata, P., Garrido, J.A., Ordovas, J.M., Blazquez, E., Alvarez-Sala, L., Rubio, M.J.,

Rodrigo, A., Oya de, M. Effects of dietary monounsaturated fatty acids on plasma

lipoproteins and apolipoproteins in women. Am. J. Clin. Nutr. 56:77-83, 1992.

79. Lichtenstein, A.H., D.L. Hachey, J.S. Millar, J.L. Jenner, L. Booth, J.M. Ordovas, E.J.

Schaefer. Measurement of human apolipoprotein B-48 and B-100 kinetics in

triglyceride-rich lipoproteins using [5,5,5-2H3]leucine. J. Lipid Res. 33:907-914, 1992.

80. Schaefer E.J. and Ordovas, J.M. Diagnosis and Management of HDL deficiency states.

High Density Lipoproteins and Atherosclerosis III (N.E. Miller and A.R. Tall, eds.) Elsevier

Science Publishers, Amsterdam, pp. 235-251, 1992.

81. López-Miranda, J.; Pérez-Jiménez, F.; Torres, A.; Espino-Montoro, A.; Gomez, P.;

Hidalgo-Rojas, L.; Ordovas, J.M.; Jiménez-Perepérez, J.A. Effect of cyclosporin on plasma

lipoproteins in bone marrow transplantation patients. Clin. Biochem. 25:379-386, 1992.

82. Granfone, A.; Campos, H.; McNamara, J.R.; Schaefer, M.M.; Lamon-Fava, S.; Ordovas,

J.M., Schaefer, E.J. Effects of estrogen replacement on plasma lipoproteins and

18

apolipoproteins in postmenopausal, dyslipidemic women. Metabolism 41:1193-1198,

1992.

83. Ordovas, J.M. Metabolism of triglyceride-rich lipoproteins: Genetic mutations

associated with its pathology. Cardiovascular Risk Factors 3:1-8, 1993.

84. Jenner, J.L., Ordovas, J.M., Lamon-Fava, S., Schaefer, M., Wilson, P.W.F., Castelli, W.P.,

Schaefer, E.J. Effects of age, gender, and menopausal status on plasma lipoprotein(a)

levels: The Framingham Offspring Study. Circulation 87:1135-1141, 1993.

85. Osada, J.; Pocoví, M.; Nicolosi, R.J.; Schaefer, E.J.; Ordovás, J.M. Nucleotide sequences

of the Macaca fascicularis apolipoprotein C-III and A-IV genes. Biochim. Biophys. Acta

Gene Struct. Expression 1172:335-339, 1993.

86. Osada, J.; Garcés, C.; Sastre, J.; Schaefer, E.J.; Ordovás, J.M. Molecular cloning and

sequence of the cynomolgus monkey apolipoprotein A-II gene. Biochim. Biophys. Acta

Gene Struct. Expression, 1172:340-342, 1993.

87. Lichtenstein, A.H.; Ausman, L.M.; Carrasco, W.; Jenner, J.L.; Ordovas, J.M.; Schaefer,

E.J. Hydrogenation impairs the hypolipidemic effect of corn oil in humans:

Hydrogenation, trans fatty acids, and plasma lipids. Arterioscler. Thromb. 13:154-161,

1993.

88. Genest, J.J., Bard, J.M., Fruchart, J.C., Ordovas, J.M., Schaefer, E.J. Familial

hypoalphalipoproteinemia in premature coronary artery disease. Arterioscler. Thromb.

13:1728-1737, 1993.

89. Reisher, S.R.; Hughes, T.E.; Ordovas, J.M.; Schaefer, E.J.; Feinstein, S.I. Increased

expression of apoliprotein genes accompanies differentiation in the intestinal cell line

Caco-2. Proc. Natl. Acad. Sci. USA, 90:5757-5761, 1993.

90. Ribaya-Mercado, J.D., Lopez-Miranda, J., Ordovas, J.M., Blanco, M.C., Fox, J.G., Russell,

R.M. Distribution of beta-carotene and vitamin A in lipoprotein fraction of ferret serum:

effect of beta-carotene supplementation. Ann. NY Acad. Sci. 691:232-237, 1993.

91. Lichtenstein, A.H.; Ausman, L.M., Carrasco, W.; Jenner, J.L.; Gualtieri, L.J., Goldin,B.R.;

Ordovas, J.M.; Schaefer, E.J. Effects of canola, corn, olive, and rice bran oil on fasting

and post-prandial lipoproteins in humans as part of a National Cholesterol Education

Program Step 1 diet. Arteriosclerosis and Thrombosis 13:1533-1542, 1993.

19

92. Lyu, L.-C., Shieh, M.-J., Ordovas, J.M., Lichtenstein, A.H., Wilson, P.W.F. and Schaefer,

E.J. Plasma lipoprotein and apolipoprotein levels in Taipei and Framingham. Arterioscler.

Thromb. 13:1429-1440, 1993.

93. Civeira, F., Pocovi, M., Cenarro, A. Garces. C, Ordovas J.M. Adenine for guanine

substitution -78 base pairs to the apolipoprotein A-I gene: relation with high density

lipoprotein cholesterol and apoA-I concentrations. Clin. Genet. 44:307-312, 1993.

94. Schaefer E.J. and Ordovas, J.M. High Density Lipoprotein Deficiency States: Diagnosis

and Management. Cardiovascular Risk Factors 3: 317-326, 1993.

95. Schaefer E.J., Genest J.J., Ordovas J.M., Salem D.N., Wilson P.W.F. Familial lipoprotein

disorders and premature coronary artery disease. Current Opinion in Lipidology 4:288-

298, 1993.

96. Serfaty-Lacrosniere, C.; Lanzberg, A.; Civeira, F.; Isaia, P.; Berg, J.; Janus, E.D.; Smith,

M.P.; Pritchard, P.H.; Frohlich, J.; Lees, R.; Ordovas, J.M.; Schaefer, E.J. Homozygous

Tangier disease and cardiovascular disease. Atherosclerosis 107:85-98, 1994.

97. Rodriguez, C.R.; Seman, L.F.; Ordovas, J.M.; Jenner, J.; Genest, J.; Schaefer, E.J.

Inheritance patterns of apolipoprotein(a) isoforms and plasma lipoprotein(a) levels.

Chemistry and Physics of Lipids 67-68:389-398, 1994.


E.J. Hypercholesterolemic effect of dietary cholesterol in diets enriched in

polyunsaturated and saturated fat. Arteriosclerosis and Thrombosis 14:168-175, 1994.


E.J. Short term consumption of a low-fat diet beneficially affects plasma lipid

concentrations only when accompanied by weight loss. Arteriosclerosis and Thrombosis

14:1751-1760, 1994.

100. Li Z, McNamara JR, Ordovas JM, Schaefer EJ. Analysis of high density lipoproteins by a

modified gradient gel electrophoresis method. J. Lipid Res. 35:1698-1711, 1994.

101. Mata P., Ordovas JM, Lopez-Miranda J, Lichtenstein AH, Clevidence B, Judd JT,

Schaefer EJ. Apolipoprotein A-IV phenotype affects diet induced plasma low density

lipoprotein cholesterol lowering. Arteriosclerosis and Thrombosis 14:884-91, 1994.

20

102. Lopez-Miranda J, Ordovas JM, Espino A, Marin C, Salas J, Lopez-Segura F, Jimenez

Pererez J, Perez Jimenez F. Human apolipoprotein A-I Gene Promoter Mutation

influences plasma low density lipoprotein response to dietary fat in young males.

Lancet 343:1246-9, 1994.

103. Schaefer EJ, Lamon-Fava S, Jenner JL, Ordovas JM, Davis CE, Lippel K, Levy RI.

Lipoprotein(a) levels predict coronary heart disease in the lipid research clinics coronary

prevention trial. JAMA 271:999-1003, 1994.

104. Schaefer EJ, Lamon-Fava S, Ordovas JM, Cohn SD, Schaefer MM, Castelli WP, Wilson

PWF. Factors associated with low and elevated plasma high density lipoprotein

cholesterol and apolipoprotein A-I levels in the Framingham Offspring Study. J. Lipid Res.

35:871-882, 1994.

105. Schaefer EJ, Lamon-Fava S, Cohn SD, Schaefer MM, Ordovas JM, Castelli WP, Wilson

PWF. Effects of age, gender, and menopausal status on plasma low density lipoprotein

cholesterol and apolipoprotein B levels in the Framingham Offspring Study. J. Lipid Res.

35:779-792, 1994.

106. Brousseau ME, Ordovas JM, Nicolosi RJ, Schaefer EJ. Effects of dietary fat saturation

on plasma lipoproteins(a) and hepatic apolipoprotein(a) mRNA concentrations in

cynomolgus monkeys. Atherosclerosis 106:109-118, 1994.

107. Ahn, Y-S, Smith D, Schaefer EJ, Ordovas JM. Dietary fat saturation affects

apolipoprotein gene expression and high density lipoprotein size distribution in Golden

Syrian hamsters. Journal of Nutrition, 124:2147-2155, 1994.

108. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, Wilson

PWF. Apolipoprotein E phenotype affects plasma lipoprotein levels in a gender and

menopausal status dependent manner. Results from the Framingham Offspring Study.

Arteriosclerosis and Thrombosis 14:1105-1113, 1994.

109. Lopez-Miranda J, Kam N, Osada J, Rodriguez C, Fernandez P, Contois J, Schaefer EJ,

Ordovas JM. Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and

editing. Biochimica and Biophysica Acta 1214:143-147, 1994.

110. Lopez-Miranda J, Ordovas JM, Mata P, Lichtenstein AH, Denke MA, Clevidence B, Judd

JT, Schaefer EJ. Effect of apolipoprotein E phenotype on diet induced plasma low

density lipoprotein cholesterol lowering. Journal of Lipid Research 35:1965-1975, 1994.

21

111. Wilson PWF, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein

E alleles, Dyslipidemia, and Coronary Heart disease: The Framingham Offspring Study.

JAMA 272:1666-1671, 1994.

112. Schaefer EJ, Genest JJ, Ordovas JM, Salem DN, Wilson PWF. Familial lipoprotein

disorders and premature coronary artery disease. Atherosclerosis 108 Suppl:S41-54,

1994.

113. Bostom AG, Gagnon DR, Cupples LA, Wilson PWF, Jenner JL, Ordovas JM, Schaefer EJ,

Castelli WP. A prospective Investigation of elevated lipoprotein(a) detected by

electrophoresis and cardiovascular disease in women. The Framingham Heart Study.

Circulation 90:1688-1695, 1994.

114. Ordovas JM. Genetic and environmental factors: Effects on plasma lipoproteins. In:

Dairy Products in Human Health and Nutrition. Serrano Rios ed. Balkema, Rotterdam

1994. 303-307.

115. Ordovas JM. Early dietary habits, cholesterolemia and coronary heart disease. In:

Dairy Products in Human Health and Nutrition. Serrano Rios ed. Balkema, Rotterdam

1994. 355-359.

116. Lyu LC, Shieh MJ, Posner BM, Ordovas JM, Dwyer JT, Lichtenstein AH, Cupples LA,

Dallal GE, Wilson PWF Schaefer, EJ. Relationship between dietary fat intake,

lipoproteins, and apolipoproteins in Taipei and Framingham. Am. J. Clin. Nutr. 60:765-

774, 1994.

117. Osada J, Fernandez-Sanchez A, Diaz-Morillo JL, Miro-Obradors MJ, Cebrian JA,

Carrizosa C, Ordovas JM, Palacios-Alaiz E. Differential effect of dietary fat saturation and

cholesterol on hepatic apolipoprotein gene expression in rats. Atherosclerosis 108:83-

90, 1994.

118. Lichtenstein, A.H., Ausman, L.M., Carrasco, W., Gualteri, L.J., Jenner, J.L., Ordovas,

J.M., Nicolosi, R.J., Goldin, B., Schaefer, E.J. Rice bran oil consumption and plasma lipid

levels in moderately hypercholesterolemic humans. Arterioscler. Thromb. 14:549-556,

1994.

119. Osada J, Lopez-Miranda J, Sastre J, Ordovas J.M. The human hepatoma cell line,

HepG2, secretes functional cholinesterase. Biochem. Molecul. Biol. 33:1099-1105, 1994.

22

120. Otto J, Ordovas JM, Smith D, Van Dongen D, Nicolosi RJ, Schaefer EJ. Lovastatin

inhibits diet induced atherosclerosis in F1B Golden Syrian Hamsters. Atherosclerosis

114:19-28, 1995.

121. 121 Ordovas JM, Lopez-Miranda J, Perez-Jimenez F, Rodriguez C, Park J, Cole T,

Schaefer EJ. Effect of apolipoprotein E and A-IV phenotypes on the low density

lipoprotein response to HMG CoA reductase inhibitor therapy. Atherosclerosis 113:157-

166, 1995.

122. 122 Lyu L, Shieh M, Bailey SM, Dallal GE, Carrasco WI, Ordovas JM, Lichtenstein

AH, Schaefer EJ. Relationship of body fat distribution with cardiovascular risk factors in

healthy chinese. Annals Epidemiology 4:434-444, 1994.

123. 123 McNamara, J.R., Cole, T.G., Contois, J.H., Ferguson, C.A., Ordovas, J.M.,

Schaefer, E.J. Immunoseparation method for measuring low-density lipoprotein

cholesterol directly from serum evaluated. Clin. Chem. 41:232-240, 1995.

124. Robins SJ, Fasulo JM, Patton GM, Schaefer EJ, Smith DE, Ordovas JM. Gender

differences in the development of hyperlipidemia and atherosclerosis in hybrid

hamsters. Metabolism 44:1326-1331, 1995.

125. Kim, Y., Christman, J.K., Fleet, J.C., Cravo, M.L., Salomon, R.N., Smith, D., Ordovas,

J.M., Selhub, J., Mason, J.B. Moderate folate deficiency does not cause global

hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of

colonic DNA in rats. Am. J. Clin. Nutr. 61:1083-1090, 1995.

126. Schaefer, E.J., Lichtenstein, A.H., Lamon-Fava, S., McNamara, J.R., Ordovas, J.M.

Lipoproteins, nutrition, aging, and atherosclerosis. Am. J. Clin. Nutr. 61 Suppl.:726S-

740S, 1995.

127. Polanco, J.I., Berciano, M.T., Crespo, P., Rodriguez, C.; Ordovas, J.M., Lafarga, M., Ortiz

Melon, J.M., Rodriguez, J.C., Leon. J. Expression of apolipoprotein E in cholesterol-

loaded macrophages of extrahepatic tissues during experimental hypercholesterolemia.

Life Sci. 56:1865-1875, 1995.

128. Brousseau, M.E., Ordovas, J.M., Osada, J., Fasulo, J., Robins, S.J., Nicolosi, R.J.,

Schaefer, E.J. Dietary monounsaturated and polyunsaturated fatty acids are

comparable in their effects on hepatic apolipoprotein mRNA abundance and liver lipid

23

concentrations when substituted for saturated fatty acids in cynomolgus monkeys. J.

Nutr. 125:425-436, 1995.

129. Perez-Jimenez F, Espino A, Lopez-Segura F, Blanco J, Ruiz-Gutierrez V, Prada JL, Lopez-

Miranda J, Jimenez-Pereperez, Ordovas JM. Lipoprotein concentrations in

normolipidemic males consuming oleic-rich diets from two different sources: olive oil

and oleic acid-rich sunflower oil. Am. J. Clin. Nutr. 62:769-775, 1995

130. Ribaya-Mercado, J.D., Ordovas, J.M., Russell, R.M. Effect of beta-carotene

supplementation on the concentrations and distribution of Carotenoids, Vitamin E,

Vitamin A, and Cholesterol in Plasma Lipoprotein and Non-lipoprotein Fractions in

Healthy Older Women. J. Am. Coll. Nutr. 14:614-620, 1995.

131. Myers,R.H., Schaefer, E.J., Wilson, P.W.F., D’Agostino, R.B., Bachman, D.L., Ordovas,

J.M., Au, J., Cobb, J.L., Wolf, P.A. Apolipoprotein E allele 4 is associated with dementia

in the Framingham Study. In: Recent advances in Alzheimer’s Disease and related

disorders. Iqba,K., Mortimer, J.A., Winblsend, B, Wisniebski, H.M. editors. (John Wiley

and Sons Ltd. New York). 64-69, 1995.

132. Brousseau ME, Schaefer EJ, Stucchi AF, Osada J, Vespa DB, Ordovas JM, Nicolosi RJ:

Diets enriched in unsaturated fatty acids enhance apolipoprotein A-I catabolism, but do

not affect either its production or hepatic mRNA abundance in Cynomolgus monkeys.


133. Schaefer EJ, Lichtenstein AH, Lamon-Fava S, Contois JH, Li Z, Rasmusen H, McNamara

JR, Ordovas JM. Efficacy of a National Cholesterol Education Program Step 2 diet in

Normolipidemic and Hypercholesterolemic Middle-Aged and Elderly Men and Women.

Arteriosclerosis and Thrombosis. 15:1079-1085, 1995.

134. Schaefer EJ, Lichtenstein AH, Lamon-Fava S, McNamara JR, Schaefer MM, Rasmussen

H, Ordovas JM. Body weight and low-density lipoprotein cholesterol changes after

consumption of a low-fat ad libitum diet. JAMA, 274:1450-1455, 1995.

135. Welty, FK, Ordovas JM, Schaefer EJ, Wilson, PWF, Young SG. Identification and

molecular analysis of two apoB gene mutations causing low plasma cholesterol levels.

Circulation 92:2036-2040; 1995.

136. Lopez-Segura F, Velasco F, Lopez-Miranda J, Castro P, Lopez R, Blanco A, Jimenez-

Pereperez J, Torres A, Trujillo J, Ordovas JM, Perez-Jimenez F. A mononusaturated fatty

24

acid enriched diet decreases plasma plasminogen activator inhibitors type I. Arterioscler.

Thromb. Vasc. Biol. 16:82-88, 1996.

137. Beard CM, Barnard RJ, Robbins DC, Ordovas JM, Schaefer EJ. Effects of diet and

exercise on qualitative and quantitative measures of LDL and its susceptibility to

oxidation. Arterioscl. Thromb. Vasc. Biol. 16:201-207; 1996.

138. Ordovas JM, Lopez-Miranda J, Mata P, Perez-Jimenez F, Lichtenstein AH, Schaefer EJ.

Gene-diet interaction in determining plasma lipid response to dietary intervention.

Atherosclerosis 118:S11-S27; 1995.

139. Robins, S.J., Fasulo, J.M., Pritzker, C.R., Ordovas, J.M., Patton, G.M. Diurnal changes

and adaptation by the liver of hamsters to an atherogenic diet. Am.J. Physiol. 269:1327-

1332, 1995.

140. Ordovas JM, Lopez-Miranda J, Mata P, Lichtenstein AH, Clevidence B, Schaefer EJ.

Genetic factors in lipoprotein responsiveness to diet in humans. In: Atherosclerosis X.

Woodford FP, Davignon J, Sniderman A. Editors. Elsevier Science, Amsterdam. pp.270-

274, 1995.

141. 141 Schaefer EJ, Jenner JL, Seman LJ, McNamara JR, Contois JH, Genest JJ, Wilson

PWF, Ordovas JM. Lp(a) and coronary heart disease. In: Atherosclerosis X. Woodford FP,

Davignon J, Sniderman A. Editors. Elsevier Science, Amsterdam. pp.79-82, 1995.

142. Ordovas JM, Lopez-Miranda J, Mata P, Perez-Jimenez F, Lichtenstein AH, Schaefer EJ.

Genetic determinants of dietary responsiveness of LDL cholesterol: a review of three

candidate gene loci. In Pennington Nutrition Series vol VI. G.A. Bray and D.H. Ryan

editors, LSU Press. Pp. 296-315, 1996.

143. Schaefer EJ, Lichtenstein AH, Lamon-Fava S, Contois JH, Li Z, Goldin BR, Rasmussen H,

McNamara JR, Ordovas JM. Comparative effects of a National Cholesterol Education

Program Step 2 diets relatively high or relatively low in fish derived fatty acids on

plasma apoproteins in middle aged and elderly subjects. Am.J.Clin.Nutr.63:234-241,

1996.

144. Myers, R.H., Schaefer, E.J., Wilson, P.W.F., D’Agostino R., Ordovas, J.M., Espino, A., Au,

R., White, R.F., Knoefel, J., Cobb, J.L., Wolf, P.A. Apolipoprotein E allele 4 association

with dementia in the Framingham study. Neurology 46:673-677, 1996.

25

145. Austin MA, Ordovas JM, Eckfeldt JH, Tracy R, Boerwinkle E, Lalouel J-M, Printz M.

Guidelines of the National Heart, Lung and Blood Institute Working Group on Blood

Drawing, Processing and Storage for Genetic Studies. Am. J. Epidemiol.144;437-441,

1996.

146. Morales M, Santana N, Soria A, Mosquera J, Ordovas JM, Novoa J, Betancor P, Valeron

P, Diaz-Chico BN, Chirino R. Effects of tamoxifen on serum lipid and apolipoprotein

levels in postmenopausal patients with breast cancer. Breast Cancer Research and

Treatment 40:265-270, 1996.

147. Pocovi M, Cenarro A, Civeira F, Myers RH, Casao E, Esteban M, Ordovas JM.

Incomplete dominance of type III Hyperlipoproteinemia is associated with the rare

apolipoprotein E2 (Arg136--Ser) variant in multigenerational pedigree studies.


148. Millen BM, Franz M, Quatromoni PA, Gagnon DR, Sonnenberg LM, Ordovas JM,

Wilson PWF, Schaefer EJ, Cupples LA. Diet an plasma Lipids in Women. I. Macronutrients

and plasma total and LDL cholesterol in Women. The Framingham Nutrition Studies. J.

Clin. Epidemiol. 49:657-663, 1996.

149. Sonnenberg LM, Quatromoni PA, Gagnon DR, Cupples LA, Franz MM, Ordovas JM,

Wilson PWF, Schaefer EJ, Posner BM. Diet and plasma lipids in women. II.

Macronutrients and plasma triglycerides, HDL, and the total to HDL cholesterol ratio in

Women. The Framingham Nutrition Studies. J. Clin. Epidemiol. 49:665-672, 1996.

150. Lindpainter K, Lee M, Larson MG, Rao VS, Pfeffer MA, Ordovas JM, Schaefer EJ, Wilson

AF, Wilson PWF, Ramachandran VS, Myers RH, Levy D. Lack of association of genetic

linkage between the ACE gene locus and left ventricular mass. N. Engl. J. Med. 334:1023-

1028, 1996.

151. Wilson PWF, Schaefer EJ, Larson M, Ordovas JM. Apolipoprotein E polymorphism and

coronary heart disease: a meta-analysis. Arterioscl. Thromb. Vasc. Biol. 16:1250-1255,

1996.

152. Lahoz C, Ordovas JM. ApoE polymorphisms, plasma lipids and coronary heart disease.

Med. Clin. (In press).

153. Cuchel M, Schwab US, Jones PJH., Vogel S, Lammi-Keefe C, Li ZL, Ordovas JM,

McNamara JR, Schaefer EJ, Lichtenstein AH. Impact of hydrogenated fat consumption of

26

endogenous cholesterol synthesis and susceptibility of low-density lipoprotein to

oxidation on moderately hypercholesterolemic individuals. Metabolism 45:241-247,

1996.

154. Mata P, Alonso R, Lopez-Farre A, Ordovas JM, Lahoz C, Garces C, Caramelo C, Codoceo

R, Blazquez E, de Oya M. Effect of dietary fat saturation on low density lipoprotein

oxidation and monocyte adhesion to human endothelial cells in vitro. Arterioscl.

Thromb. Vasc. Biol. 16:1347-1355, 1996.

155. Ordovas JM. Anti-cholesterol Antibodies and Plaque Formation. Nutrition Reviews

54:124-127, 1996.

156. 156 Ordovas JM. Comments to the second session of the International

Symposium on omega-3, lipoproteins and atherosclerosis. In: Omega-3, lipoproteins and

atherosclerosis. J. Davignon, J.Ch. Fruchart, J.M. Ordovas Editors. John Libbey Eurotext,

Paris 1996. pp. 83-6.

157. 157 Bostom AG, Cupples LA, Jenner JL, Ordovas JM, Seman LJ, Wilson PWF,

Schaefer EJ, Castelli, WP. Elevated Plasma Lipoprotein(a) and premature coronary heart

disease in Framingham men: a prospective study. JAMA 276:544-548, 1996.

158. 158 Carmena R, Ascaso JF, Camejo G, Varela G, Hurt-Camejo E, Ordovas JM,

Martinez-Valls J, Bergstom M, Haden M, Wallin B. Effect of olive oil and sunflower oils

on low density lipoproteins level, composition, size, oxidation and interaction with

arterial proteoglycans. Atherosclerosis 125:243-255, 1996

159. 159 Espino-Montoro A, Lopez-Miranda J, Castro P, Rodriguez M, Lopez-Segura F,

Blanco A, Jimenez-Pereperez JA, Ordovas JM, Perez-Jimenez F. Monounsaturated fatty

acid enriched diets lower plasma insulin levels and blood pressure in healthy young

men. Nutr. Metab. Cardiovasc. Dis. 6:147-154, 1996.

160. 160 Ordovas JM. Genes and diet. Clin. Invest. Arterioscl. 8:26-36, 1996.

161. 161 Li ZL, McNamara JR, Fruchart JC, Luc G, Bard JM, Ordovas JM, Wilson PWF,

Schaefer EJ. Effects of gender and menopausal status on plasma lipoprotein subspecies

and particle sizes. Journal Lipid Research 37:1886-1896, 1996.

27

162 Civeira F, Pocovi M, Cenarro A, Casao E, Vilella E, Joven J, Gonzalez J, Garcia-Otin AL,

Ordovas JM. ApoE variants in patients with type III Hyperlipoproteinemia.


162. Lahoz C, Osgood D, Wilson PWF, Schaefer EJ, Ordovas JM. Frequency of phenotype-

genotype discrepancies at the apolipoprotein E locus in a large population study. Clin.

Chem 42:1817-1823, 1996.

163 Campos H, Lopez-Miranda J, Rodriguez C, Albajar M, Schaefer EJ, Ordovas JM.

Urbanization elicits a more atherogenic lipoprotein profile in carriers of the

apolipoprotein A-IV-2 allele compared to A-IV-1 homozygotes. Arterioscl. Thromb. Vasc.

Biol. 17:1074-1081, 1997.

164 Jansen S, Lopez-Miranda J, Salas J, Ordovas JM, Castro P, Marin C, Ostos MA, Lopez-

Segura F, Jimenez-Pereperez JA, Blanco A, Perez-Jimenez F. Effect of 347-serine

mutation in apolipoprotein A-IV on plasma lipid response to dietary fat. Arterioscl.

Thromb. Vasc. Biol. 17:1532-1538, 1997.

165 Lopez-Miranda J, Ordovas JM, Marin C, Jansen S, Lopez-Segura F, Salas J, Blanco A,

Jimenez-Pereperez J, Perez-Jimenez F. The SstI polymorphic site at the apolipoprotein C-

III gene predicts plasma low density lipoprotein response to changes in dietary fat in

young men. American Journal of Clinical Nutrition. 66(1):97-103, 1997.

166 Welty FK, Lichtenstein AH, Barrett PHR, Jenner J, Dolnikowski G, Ordovas JM, Schaefer EJ.

Decreased production and increased metabolism of apolipoprotein B-100 and

apolipoprotein B-67/B-100 heterozygotes. Arterioscl. Thromb. Vasc. Biol. 17:881-888,

1997.

167 Schaefer EJ, Lamon-Fava S, Ausman LM, Ordovas JM, Clevidence BA, Judd JT, Goldin BR,

Woods M. Gorbach S, Lichtenstein AH. Individual variability in lipoprotein cholesterol

response to National Cholesterol Education Program Step 2 diets. Am. J. Clin. Nutr.

65:823-830, 1997.

168 Tilly-Kiesi M, Lichtenstein AH, Ordovas JM, Cheung MC, Dolnikowski GG, Taskinen M-R,

Schaefer EJ. Subjects with apoA-I(Lys107-0) exhibit enhanced fractional catabolic rate of

apoA-I in Lp(AI) and apoA-II in Lp(AI with AII). Arterioscl. Thromb. Vasc. Biol. 17:873-880,

1997.

28

169 Johnson RC, Chapman SM, Ordovas JM, Mayadas TN, Herz J, Hynes RO, Schaefer EJ,

Wagner DD. Absence of P-Selectin reduces the progression of atherosclerosis. J. Clin.

Invest. 99:1037-1043, 1997.

170 Farrer LA, Cupples LA, Kukull WA, Volicer L, Wells JM, Kurz A, Green RC, Cui H, Duara R,

Auerbach SA, Larson E, Lautenschlager N, Wolf PA, Agostino R, Ordovas JM, Schaefer EJ,

Growdon JH, Haines JL. Risk of Alzheimer disease is associated with parental age among

apolipoprotein E4 heterozygotes. Alzheimer’s Research 3:83-91, 1997.

171 Kiel DP, Myers RH, Cupples LA, Kong XF, Zhu XH, Ordovas JM, Schaefer EJ, Felson DT, Rush

D, Wilson PWF, Eisman JA, Holick MF. The BsmI Vitamin D receptor restriction fragment

length polymorphism (bb) influences the effect of calcium intake on bone mineral

density. J. Bone Miner. Res. 1997;12:1049-1057.

172 Pedro-Botet J, Ordovas JM. Polimorfismo genetico de la apolipoproteina E y respuesta al

tratamiento farmacologico de las hiperlipemias. Clin. Invest. Arterioscl. 9:110-113, 1997.

173 Lahoz C, Ordovas JM. Apolipoprotein E and Alzheimer's disease. Revista Clinica Espanola.

197(2):73-4, 1997.

175 Tilly-Kiesi M. Lichtenstein AH. Joven J. Vilella E. Cheung MC. Carrasco WV. Ordovas JM.

Dolnikowski G. Schaefer EJ. Impact of gender on the metabolism of apolipoprotein A-I in

HDL subclasses LpAI and LpAI:AII in older subjects. Arteriosclerosis, Thrombosis &

Vascular Biology. 17(12):3513-8,1997 Dec.

163. Ordovas JM. Genetics of Lipid Metabolism. Cardiovascular Risk Factors 7:138-156,

1997.

164. J.M. Ordovas, P.W.F. Wilson, L.A. Cupples, J.R. McNamara, E.J. Schaefer, Lipids and

lipoproteins as risk factors for atherosclerosis: New biochemical and genetic markers.

Atherosclerosis 134 (1-2) (1997) pp. 11-12.

165. Smith D, Pedro-Botet J, Cantuti-Castelvetri I, Schaefer EJ, Ordovas JM. Influence of

age, diet and laboratory caging on lipid profile among F1B hamsters. Nutrition Research

17:1569-1575, 1997.

166. Lopez-Miranda J, Ordovas JM, Ostos MA, Marin C, Jansen S, Salas J, Blanco-Molina A,

Jimenez-Pereperez, Lopez-Segura F, Perez-Jimenez F. Dietary fat clearance in normal

29

subjects is modulated by genetic variation at the apolipoprotein B gene locus. Arterioscl.

Thromb. Vasc. Biol. 17:1765-1773 (1997).

167. Lahoz C., Ordovas JM. Apo E: blood lipids, ischemic cardiopathy and Alzheimer's

disease. Medicina Clinica. 109(1):31-6, 1997.

168. Alvarez-Sala LA. Mata P. Blazquez E. Garrido JA. Ordovas JM. Rubio, MJ. de Oya M.

Pravastatin increases the activity of the LDL receptors in lymphocytes of individuals with

heterozygous familial hypercholesterolemia. Revista Clinica Espanola. 197(5):317-22,

1997.

169. Welty FK, Lichtenstein AH, Barrett PHR, Dolnikowski GG, Ordovas JM, Schaefer EJ.

Production of apolipoprotein B-67 in apolipoprotein B-67/B-100 heterozygotes:

technical problems associated with leucine contamination in stable isotope studies. J.

Lipid Res. 38:1535-1543 (1997).

170. Ehrenborg E, Clee SM, Pimstone SN, Reymer PWA, Benlian P, Hoogendijk CF, Davis HJ,

Bissada N, Miao L, Gagne SE, Greenberg LJ, Henry R, Henderson H, Ordovas JM, Schaefer

EJ, Kastelein JJP, Kotze MJ, Hayden MR. Ethnic Variation and In vivo Effects of the –

93tg promoter variant in the lipoprotein lipase gene. Arterioscler Thromb Vasc Biol

1997;17:2672-2678.

171. Lahoz C. Alonso R. Ordovas JM. Lopez-Farre A. de Oya M. Mata P. Effects of dietary fat

saturation on eicosanoid production, platelet aggregation and blood pressure. European

Journal of Clinical Investigation. 27(9):780-7, 1997.

172. Jansen S. Lopez-Miranda J. Ordovas JM. Zambrana JL. Marin C. Ostos MA. Castro P.

McPherson R. Lopez Segura F. Blanco A. Jimenez Pereperez JA. Perez-Jimenez F. Effect

of 360His mutation in apolipoprotein A-IV on plasma HDL-cholesterol response to

dietary fat. Journal of Lipid Research. 38(10):1995-2002, 1997

173. Lopez-Miranda, Ordovas JM, Blanco-Molina A, Perez-Jimenez F. Postprandial Lipemia

and Atherosclerosis. Clin. Invest. Arterioscl. 9: 158-172, 1997.

174. Lopez J, Ordovas JM, Jansen S, Salas J, Lopez F, Blanco A, Jimenez JA, Perez F.

Interaccion genes-dieta como determinante de los niveles plasmaticos de colesterol. In:

Metabolismo Lipidico. M. de Oya and C. Garces Editors. IDEPSA, Madrid (Spain). Pp:325-

337, 1997.

30

175. L.J. Seman, C. DeLuca, J.M. Ordovas, P.W.F. Wilson, L.A. Cupples, E.J. Schaefer, A

comparison of lipoprotein (a)-cholesterol levels and sinking prebeta lipoprol with heart

disease risk in the Framingham heart study. Atherosclerosis 134 (1-2) (1997) pp. 150-

150.

176. M.R. Hayden, S.E. Gagne, M.G. Larson, M.E. Wittekoek, S.N. Pimstone, E.J. Schaefer,

J.C. Defesche, P.W.F. Wilson, J.J.P. Kastelein, J.M. Ordovas, Common mutations in the

lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart

disease. Atherosclerosis 134 (1-2) (1997) pp. 12-12.

177. O’Donnell CJ, Lindpainter K, Larson MG, Rao, V.S., Ordovas JM, Schaefer EJ, Myers RH,

Levy D. Evidence for association and genetic linkage of the angiotensin converting

enzyme locus with hypertension and blood pressure in men but not women in the

Framingham Heart Study. Circulation 97:1766-1772 . 1998.

178. Mata P, Lopez-Miranda J, Pocovi M, Alonso R, Lahoz C, Marin C, Garces C, Cenarro A,

Perez-Jimenez F, de Oya M, Ordovas JM. Human apolipoprotein A-I gene promoter

mutation influences plasma low density lipoprotein cholesterol response to dietary fat

saturation. Atherosclerosis 137:367-376 (1998).

179. Welty FK, Ordovas JM, Wilson PWF, Lahoz C, Tucker K, Schaefer EJ, Causes and

consequences of LDL-cholesterol <70 mg/dl over a 25 year period in the Framingham

Offspring. Arterioscl. Thromb. Vasc. Biol. 18:1745-51, 1998

180. Ordovas JM. Fast ultracentrifugation methods for the separation of plasma

lipoproteins. In: Lipoprotein Protocols. Methods in Molecular Biology Series. Ordovas JM

Editor. Humana Press. Totowa, NJ, pp. 93-104, 1998.

181. Ordovas JM. Separation of Small Size DNA Fragments Using Agarose Gel

Electrophoresis In: Lipoprotein Protocols. Methods in Molecular Biology Series. Ordovas

JM Editor. Humana Press. Totowa, NJ, pp-35-42, 1998

182. Karge WH, Schaefer EJ, Ordovas JM. Quantification of mRNA by polymerase chain

reaction (PCR) using an internal standard and a nonradioactive detection method. In:

Lipoprotein Protocols. Methods in Molecular Biology Series. Ordovas JM Editor. Humana

Press. Totowa, NJ, pp-43-62, 1998.

31

183. Ordovas JM and Osgood D. Preparative isolation of plasma liproteins using fast

protein liquid chromatography (FPLC). In: Lipoprotein Protocols. Methods in Molecular

Biology Series. Ordovas JM Editor. Humana Press. Totowa, NJ, pp-105-112, 1998.

184. Ordovas JM. Separation of apolipoproteins by polyacrylamide gele electrophoresis. In:

Lipoprotein Protocols. Methods in Molecular Biology Series. Ordovas JM Editor. Humana

Press. Totowa, NJ, pp-3113-130, 1998.

185. Rafael Carmena-Ramon, Juan F. Ascaso, Jose Real, Jose M. Ordovas, Rafael Carmena.

Genetic Variation at the Apo A-IV Gene Locus and Response to Diet in Familial

Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 18:1266-74, 1998

186. Rafael F. Carmena-Ramon, Jose M. Ordovas, Juan F. Ascaso, Jose Real, Maria A. Priego,

Rafael Carmena. Influence of genetic variations of the apo A-I gene locus on lipid levels

and response to diet in familial hypercholesterolemia. Atherosclerosis 139:107-113,

1998

187. Ordovas JM, Lopez-Miranda J, Mata P, Perez-Jimenez F. Gene-environment

interactions in lipoprotein metabolism. Nutrition Metabolism and Cardiovascular

Diseases 8:47-61, 1998.

188. Jansen S, Lopez-Miranda J, Salas J, Castro P, Paniagua J.A., Lopez-Segura F, Ordovas

JM, Jimenez-Pereperez JA, Blanco A, Perez-Jimenez F. Plasma lipid responses to

hypolipidemic diets in young healthy non-obese men varies with body mass index. J.

Nutr 128:1144-1149, 1998.

189. Millar JS, Lichtenstein AH, Dolnikowski, GG, Ordovas JM, Schaefer EJ. Proposal of a

multicompartmental model for use in the study of apolipoprotein E metabolism.

Metabolism, 47: 922-928, 1998

190. Schwab US, Vogel S, Lammi-Keefe CJ, Ordovas JM, Schaefer EJ, Li Z, Ausman LM,

Gualteri L, Goldin BR, Furr HC, Lichtenstein AH. Varying dietary fat type of reduced-fat

diets has little effect on the susceptibility of low density lipoprotein to oxidative

modification in moderately hypercholesterolemic subjects. J. Nutr. 128:1703-9, 1998.

191. Ordovas, J.M. Handbook of Lipoprotein Testing (Book review). Clin.Chem. 44: 1368.

1998.

32

192. Ordovas J.M. La genetica de las hiperlipidemias. (Genetics of Hyperlipidemia) In:

Hiperlipidemias: Clinica y Tratamiento. Editors: R. Carmena and J.M. Ordovas. Doyma

Scientific Medical Communications, Barcelona, Spain. 1998.

193. Ordovas J.M. Aspectos metabolicos y geneticos de las alteraciones de las lipoproteinas

de alta densidad (metabolic and genetic alterations of hypoalphalipoproteinemia). In:



194. Ordovas J.M. and Carmena R. Factores de Riesgo Cardiovascular (Cardiovascular Risk

Factors). In: Hiperlipidemias: Clinica y Tratamiento. Editors: R. Carmena and J.M.

Ordovas. Doyma Scientific Medical Communications, Barcelona, Spain. 1998.

195. Carmena R, Ordovas JM. Disbetalipoproteinemia familiar tipo III (Type III familial

dysbetalipoproteinemia). In: Hiperlipidemias: Clinica y Tratamiento. Editors: R. Carmena

and J.M. Ordovas. Doyma Scientific Medical Communications, Barcelona, Spain. 1998.

196. Carmena R, Ordovas JM. Tratamiento farmacologico de las hiperlipoproteinemias. In:



197. Carmena R, Ordovas JM. Tratamiento dietetico de las hiperlipoproteinemias. In:



198. Ordovas JM. Terapia genica de las hiperlipoproteinemias. In: Hiperlipidemias: Clinica y

Tratamiento. Editors: R. Carmena and J.M. Ordovas. Doyma Scientific Medical

Communications, Barcelona, Spain. 1998.

199. Ordovas, J.M. Handbook of Lipoprotein Testing (Book review). Arterioscl. Thromb.

Vasc. Biol.

200. McNamara, J.R., Shah, P.K., Nakajima, K., Cupples, A.L., Wilson, P.W.F., Ordovas, J.M.,

Schaefer, E.J. Remnant lipoprotein cholesterol and triglyceride reference ranges from

the Framingham Heart Study. Clin. Chem. 44:1224-32, 1998.

201. Pitman WA, Osgood DP, Smith D, Schaefer EJ, Ordovas JM. The effects of diet and

lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA

33

levels for the LDL receptor and HMG CoA reductase in F1B hamsters. Atherosclerosis.

138:43-52, 1998.

202. Ordovas JM. Lipoproteins Physiology. Encyclopedia of Human Nutrition. Fallon, N.

Editor Academic Press, pp. 1201-1209, 1999.

203. Miguel Pocovi, Ana Cenarro, Fernando Civeira, Miguel A. Torralba, Juan I. Perez-Calvo,

Pilar Mozas, Pilar Giraldo, Manuel Giralt, Richard H. Myers, L. Adrienne Cupples and

Jose M. Ordovas. The beta-glucocerebrosidase gene locus: a common link for Gaucher

disease and familial hypoalphalipoproteinemia. The Lancet 351:1919-23, 1998

204. Stucchi AF, Nicolosi RJ, Karge WH, Ausman LM, Ordovas JM. Dietary cholesterol affects

serum lipids, lipoproteins and LDL metabolism in Cynomolgus monkeys in a dose-

dependent manner. J. Nutr. 128: 1104-1113, 1998.

205. Schaefer EJ, Brousseau ME, McNamara JR, Cohn JS, Lichtenstein AH, Genest J, Seman

LJ, Lamon-Fava, S, Ordovas JM. Diagnosis and management of lipoprotein disorders: a

review and update. Part I: lipoprotein metabolism, familial lipoprotein disorders, and

the rationale for treatment of lipid disorders. Nutr. Clin. Care. 1:71-79, 1998.

206. Schwab, US, Sarkkinen ES, Lichtenstein AH, Li Z, Ordovas JM, Schaefer EJ, Uusitupa

MIJ. The effect of quality and amount of dietary fat on the susceptibility of low density

lipoprotein to oxidation in subjects with impaired glucose tolerance. Eur.J.Clin.Nutr.

52:452-458, 1998.

207. Salas J. Jansen S. Lopez-Miranda J. Ordovas JM. Castro P. Marin C. Ostos MA. Bravo

MD. Jimenez-Pereperez J. Blanco A. Lopez-Segura F. Perez-Jimenez F. The SstI

polymorphism of the apolipoprotein C-III gene determines the insulin response to an

oral-glucose-tolerance test after consumption of a diet rich in saturated fats. American

Journal of Clinical Nutrition. 68:396-401, 1998.

208. Ostos MA, Lopez-Miranda J, Ordovas JM, Marin C, Blanco A, Castro P, Lopez-Segura F,

Jimenez-Pereperez J, Perez-Jimenez F. Dietary fat clearance is modulated by genetic

variation in apolipoprotein A-IV gene locus. J. Lipid Res. 39:2493-500, 1998.

209. Ordovas JM. The genetics of serum lipid responsiveness to dietary interventions.

Proceedings of the Nutrition Society. 58:171-187, 1999.

34

210. Aguilar CA, Talavera G, Ordovas JM, Barriguete JA, Guillen LE, Leco ME, Pedro-Botet J,

Gonzalez-Barranco J, Gomez-Perez FJ, Rull JA. 1999. The apolipoprotein E4 allele is not

associated with an abnormal lipid profile in a Native American population following its

traditional lifestyle. Atherosclerosis. 142:409-14.

211. Cenarro A, Pocovi M, Giraldo P, Garcia-Otin AL, Ordovas JM. 1999. Plasma lipoprotein

responses to enzyme-replacement in Gaucher's disease [letter]. Lancet. 353:642-3.

212. Miranda, JL; Ordovas, JM; Jimenez, FP Interaction between genes and diet as a

determinant of the plasma levels of cholesterol. Med. Clin. 111:546-551, 1998.

213. Blanco-Molina A, Castro G, Martin-Escalante D, Bravo D, Lopez-Miranda J, Castro P,

Lopez-Segura F, Fruchart JC, Ordovas JM, Perez-Jimenez F. 1998. Effects of different

dietary cholesterol concentrations on lipoprotein plasma concentrations and on

cholesterol efflux from Fu5AH cells. Am. J. Clin. Nutr. 68:1028-33.

214. Ordovas JM, Schaefer EJ. Genes, variation of cholesterol and fat intake and serum

lipids. Current Opinion in Lipidology. 10:15-22, 1999.

215. Acton S, Osgood D, Donoghue M, Corella D, Pocovi M, Cenarro A, Mozas P, Keilty J,

Squazzo S, Woolf EA, Ordovas JM. Association of polymorphisms at the SR-BI gene locus

with plasma lipid levels and body mass index in a Caucasian population. Arteriosclerosis,

Thrombosis & Vascular Biology 19: 1734-1743. 1999.

216. Ramos-Galluzi and Ordovas JM. Genotyping method for point mutation detection in

the Intestinal Fatty Acid Binding Protein, using fluorescent probes. Clin Chem. 45:1092-

4,1999.

217. Larson I, Hoffmann MM, Ordovas JM, Schaefer EJ, Marz W, Kreuzer J. The LPL HindIII

RFLP: association with TC and LDL-C, but not with HDL-C and TG in 342 females. Clin

Chem. 1999; 45:963-968.

218. Gagne SE, Larson MG, Pimstone SN, Schaefer EJ, Kastelein JJP, Wilson PWF,

Ordovas,JM, Hayden, MR. A common truncation variant of LPL (Ser447X) confers

protection against coronary heart disease: the Framingham Offspring Study. Clin Genet

1999; 55:450-454.

35

219. Couture P, Otvos JD, Cupples LA, Wilson PWF, Schaefer EJ, Ordovas JM. Association of

the C-514T polymorphism in the HL: gene with variations in lipoprotein subclass

profiles: The Framingham Study. Arterioscler Thromb Vasc Biol 2000; 20:815-822.

220. Couture P, Otvos JD, Cupples LA, Wilson PWF, Schaefer EJ, Ordovas JM. Association of

the A-204C polymorphism in the CYP7 gene with variations in plasma LDL-C levels in the

Framingham Offspring Study. J Lipid Res 40: 1883-1889. 1999.

221. Ordovas JM, Schaefer EJ. Treatment of dyslipidemia: genetic interactions with diet

and drug therapy. Current Atherosclerosis Reports 1:16-23, 1999

222. Ordovas JM, Galluzzi J. Genetic predictors of plasma lipid response to diet

intervention. Current Atherosclerosis Reports 1:196-203. 1999.

223. Ordovas JM. Olive Oil and Table Olives. The Wiley Encyclopedia of Food Science and

Technology, 2nd Edition. Edited by Frederick J. Francis. Blackwell’s (1999).

224. Kastelein, JJP; Ordovas, JM; Wittekoek, ME, Pimstone, SN; Wilson, PWF; Gagne, SE;

Larson, MG; Schaefer, EJ; Boer, JMA; Gerdes, C; Hayden, MR. Two common mutations

(D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma

lipids and lipoproteins in men and women. Clin Genet. 56: 297-305. 1999.

225. Lamon-Fava, S; Ordovas, JM; Schaefer, EJ. Estrogen increases apolipoprotein (Apo) A-I

secretion in Hep G2 cells by modulating transcription of the apo A-I gene promoter

Arterioscler Thromb Vasc Biol. 19:2960-2965. 1999.

226. Ordovas, JM. Endothelial lipase: A new member of the family. Nutr Rev. 57:284-287

Part 1. 1999.

227. Schaefer, EJ; Lahoz, C; Couture, P, Cendoroglo, M; Russo, G; Cupples, LA; Wilson, PWF;

Ordovas, JM. High-density lipoprotein as a coronary heart disease risk factor and gene

mutations affecting high-density lipoprotein cholesterol levels: results from the

Framingham Heart Study. Atherosclerosis, 146: S4-S5 Suppl. 1. 1999

228. Perez-Jimenez, F; Castro, P; Lopez-Miranda, J, Paz-Rojas, F; Blanco, A; Lopez-Segura, F;

Velasco, F; Marin, C; Fuentes, F; Ordovas, JM. Circulating levels of endothelial function

are modulated by dietary monounsaturated fat. Atherosclerosis, 145:351-358. 1999.

36

229. Seman, LJ; DeLuca, C; Jenner, JL, Cupples, LA; McNamara, JR; Wilson, PWF; Castelli,

WP; Ordovas, JM; Schaefer, EJ. Lipoprotein(a)-cholesterol and coronary heart disease in

the Framingham Heart Study. Clin Chem, 45:1039-1046. 1999.

230. Ordovas JM. CETP, Diabetic dyslipidemia and postprandial lipemia. Cardiovascular Risk

Factors 9:107-13.1999.

231. Doreen Osgood-McWeeney, Jennifer R. Galluzzi, and Jose M. Ordovas. Allelic

Discrimination for Single Nucleotide Polymorphisms in the Human Scavenger Receptor

Class B Type 1 Gene Locus Using Fluorescent Probes. Clin Chem. 46: 118-119. 2000.

232. Schaefer EJ, Augustin JL, Schaefer MM, Rasmussen H, Ordovas JM, Dallal GE, Dwyer JT.

Lack of efficacy of a food frequency questionnaire in assessing dietary macronutrient

intakes in subjects consuming diets of known composition. Am. J. Clin. Nutr. 71:746-751,

2000.

233. Ordovas JM, Cupples LA, Corella D, Otvos JD, Osgood D, Martinez A, Lahoz C, Coltell O,

Wilson PWF and Schaefer EJ. Association of The CETP TaqIB Polymorphism With

Variations In Lipoprotein Subclasses And Coronary Heart Disease Risk: The Framingham

Study. Arterioscler Thromb Vasc Biol, 20:1323-1329. 2000.

234. Corella D, Sáiz C, Guillén M, Portolés O, Mulet F, González JI, Ordovás JM. Association

of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid

levels in a healthy Spanish population. 152:367-376; 2000

235. Couture P, Otvos JD, Cupples LA, Wilson PWF, Schaefer EJ, Ordovas JM. Absence of

association between genetic variation in the promoter of the microsomal triglyceride

transfer protein gene and plasma lipoproteins in the Framingham Offspring Study.

Atherosclerosis, 148:337-343, 2000.

236. Larson IA, Ordovas JM, DeLuca C, Barnard JR, Feussner G, Schaefer EJ. Association of

apolipoprotein E genotype with plasma apoE levels. Atherosclerosis. 2000;148:327-35.

237. Blanco-Molina A, Martin-Escalante D, Bravo D, Gonzalez-Reyes JA, Lopez-Miranda J,

Ordovas JM, Lopez-Segura F, Jimenez-Pereperez JA, Perez-Jimenez F. High density

lipoproteins protect endothelial cells from apoptosis induced by oxidized low-density

lipoproteins. Protoplasma 211: 198-206. 2000.

37

238. El-Swefy S, Schaefer EJ, Seman LJ, van Dongen D, Sevanian A, Smith DE, Ordovas JM,

El-Sweidy M, Meydani M. The effect of vitamin E, probucol, and lovastatin on oxidative

status and aortic fatty lessions in hyperlipidemic diabetic hamsters. Atherosclerosis,

149:277-286, 2000.

239. Carmena-Ramon R, Real JT, Ascaso JF, Ordovas JM, Carmena R. Effect of

apolipoprotein E genotype on lipid levels and response to diet in familial

hypercholesterolemia. Nutr. Metab. Cardiov. Dis. 10:7-13, 2000.

240. Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL,

Thurston LM, Fitzgerald MG, Yask-McKenna D, O’Neill G, Eberhart GP, Weiffenbach B,

Ordovas JM, Freeman MW, Brown RH, Gu JZ. Novel mutations in the gene encoding

ATP-binding cassette 1 in four Tangier disease kindreds. J. Lipid Res. 41:433-441, 2000.

241. Schwab US, Ausman LM, Vogel S, Li ZL, Lammi-Keefe CJ, Goldin BR, Ordovs JM,

Schaefer EJ, Lichtenstein AH. Dietary cholesterol increases the susceptibility of low

density lipoprotein to oxidative modification. Atherosclerosis, 149:83-90, 2000.

242. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PWF,

Ordovas JM, Schaefer EJ, Dawson-Hughes B, Kiel DP. Dietary vitamin K intakes are

associated with hip fracture but not with bone mineral density in elderly men and

women. Am. J. Clin. Nutr. 2000;71:1201-8.

243. Castro P, Lopez-Miranda JL, Gomez P, Escalante DM, Lopez-Segura F, Martin A,

Fuentes F, Blanco A, Ordovas JM, Perez-Jimenez F. Comparison of an oleic acid-enriched

diet vs. NCEP-I diet on LDL susceptibility to oxidative modifications. Eur. J. Clin. Nutr.

54:61-67, 2000.

244. Sun Z, Larson IA, Ordovas JM, Barnard JR, Schaefer EJ. Effects of age, gender and

lifestyle factors on plasma apolipoprotein A-IV concentration. Atherosclerosis.

2000;151:381-388.

245. Shearman AM, Ordovas JM, Cupples LA, Schaefer EJ, Harmon EJ, Shao YJ, Keen JD,

DeStefano AL, Joost O, Wilson PWF, Housman DE, Myers RH. Evidence for a gene

influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the

Framingham Study. Human Molecular Genetics, 9:1315:1320. 2000.

246. Ordovas JM. ABC1: The gene for Tangier and beyond. Nutrition Reviews 58:76-79.

2000.

38

247. Ordovas JM, Schaefer EJ. Genetic determinants of plasma lipid response to dietary

intervention: the role of the APOA1/C3/A4 gene cluster and the APOE gene. British

Journal of Nutrition. 83:S127-S136. 2000.

248. Meigs JB, Ordovas JM, Cupples LA, Singer DE, Nathan DM, Schaefer EJ, Wilson PWF.

Apolipoprotein E Isoform Polymorphisms are not associated with Insulin resistance: The

Framingham Offspring Study. Diabetes Care. 23:669-674:2000.

249. Booth SL. Tucker KL. Chen H. Hannan MT. Gagnon DR. Cupples LA. Wilson PW.

Ordovas J. Schaefer EJ. Dawson-Hughes B. Kiel DP. Dietary vitamin K intakes are

associated with hip fracture but not with bone mineral density in elderly men and

women [see comments]. American Journal of Clinical Nutrition. 71(5):1201-8, 2000 May.

250. Lopez-Miranda, J; Marin, C; Castro, P; Gomez, F; Gonzalez-Amieva, A; Paz, E; Bravo, D;

Ordovas, JM; Jimenez-Pereperez, J; Perez-Jimenez, F. The effect of apolipoprotein B xbal

polymorphism on plasma lipid response to dietary fat European Journal Of Clinical

Investigation, 30:678-684; 2000.

251. Jansen, S; Lopez-Miranda, J; Castro, P; Lopez-Segura, F; Marin, C; Ordovas, JM; Paz, F;

Jimenez-Pereperez, J; Fuentes, F; Perez-Jimenez, F. Low-fat and high-monounsaturated

fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in

young, healthy, normolipemic men. American Journal of Clinical Nutrition, 72:36-41;

2000.

252. Ostos, MA; Lopez-Miranda, J; Marin, C; Castro, P; Gomez, P; Paz, E; Pereperez, JAJ;

Ordovas, JM; Perez-Jimenez, F The apolipoprotein A-IV-360His polymorphism

determines the dietary fat clearance in normal subjects. Atherosclerosis, 153: 209-217,

2000.

253. Smith, D; Espino-Montoro, A; Perez-Jimenez, F; Pedro-Botet, J; Pereperez, JJ; Ordovas,

JM. Effect of a high saturated fat and cholesterol diet supplemented with squalene or

beta-sitosterol on lipoprotein profile in F1B hamsters. Nutrition Research, 20: 1309-

1318; 2000.

254. Ordovas JM. Genetic polymorphisms and activity of cholesterol ester transfer protein

(CETP): should we be measuring them? Clin Chem Lab Med. 2000 Oct;38(10):945-9.

39

255. Zee RY, Myers RH, Hannan MT, Wilson PW, Ordovas JM, Schaefer EJ, Lindpaintner K,

Kiel DP. Absence of linkage for bone mineral density to chromosome 12q12-14 in the

region of the vitamin D receptor gene. Calcif Tissue Int. 2000 Dec;67(6):434-9.

256. Ordovas JM. Gene-diet interaction and plasma lipid response to dietary intervention.

Curr Atheroscler Rep. 2001 May;3(3):200-8.

257. Recalde D, Velez-Carrasco W, Civeira F, Cenarro A, Gomez-Coronado D, Ordovas JM,

Pocovi M. Enhanced fractional catabolic rate of apo A-I and apo A-II in heterozygous

subjects for apo A-I(Zaragoza) (L144R). Atherosclerosis. 2001 Feb 15;154(3):613-23.

258. Brousseau ME, Bodzioch M, Schaefer EJ, Goldkamp AL, Kielar D, Probst M, Ordovas

JM, Aslanidis C, Lackner KJ, Bloomfield Rubins H, Collins D, Robins SJ, Wilson PW,

Schmitz G. Common variants in the gene encoding ATP-binding cassette transporter 1 in

men with low HDL cholesterol levels and coronary heart disease. Atherosclerosis 2001

Feb 15;154(3):607-11.

259. Lahoz C, Schaefer EJ, Cupples LA, Wilson PWF, Levy D, Osgood D, Parpos S, Pedro-

Botet J, Daly JA, Ordovas JM. Apolipoprotein E genotype and cardiovascular disease in

the Framingham Heart Study. Atherosclerosis 2001 Feb 15;154(3):529-37.

260. Humphries SE, Ordovas JM. Genetics and atherosclerosis: broadening the horizon.

Atherosclerosis. 2001 Feb 15;154(3):517-9.

261. Pinto X, Vilaseca MA, Garcia-Giralt N, Ferrer I, Pala M, Meco JF, Mainou C, Ordovas

JM, Grinberg D, Balcells S. Homocysteine and the MTHFR 677C-->T allele in premature

coronary artery disease. Case control and family studies. Eur J Clin Invest. 2001

Jan;31(1):24-30.

262. McNamara JR, Shah PK, Nakajima K, Cupples LA, Wilson PW, Ordovas JM, Schaefer EJ.

Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk

factor in women: results from the Framingham Heart Study. Atherosclerosis. 2001

Jan;154(1):229-36.

263. Smith D, Pedro-Botet J, Cantuti-Castelvetri I, Shukitt-Hale B, Schaefer EJ, Joseph J,

Ordovas JM. Influence of photoperiod, laboratory caging and aging on plasma lipid

response to an atherogenic diet among F1B hamsters. Int J Neurosci. 2001;106(3-4):185-

94.

40

264. Weggemans RM, Zock PL, Ordovas JM, Pedro-Botet J, Katan MB. Apoprotein E

genotype and the response of serum cholesterol to dietary fat, cholesterol and cafestol.

Atherosclerosis. 2001 Feb 15;154(3):547-55.

265. Ordovas JM. Genetics, postprandial lipemia and obesity. Nutr Metab Cardiovasc Dis.

2001 Apr;11(2):118-33.

266. Millar JS, Lichtenstein AH, Ordovas JM, Dolnikowski GG, Schaefer EJ. Human

triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100

metabolism. Atherosclerosis. 2001 Apr;155(2):477-85.

267. Chaves FJ, Real JT, Garcia-Garcia AB, Puig O, Ordovas JM, Ascaso JF, Carmena R,

Armengod ME. Large rearrangements of the LDL receptor gene and lipid profile in a FH

Spanish population. Eur J Clin Invest. 2001 Apr;31(4):309-17.

268. Corella D, Tucker K, Lahoz C, Coltell O, Cupples L.A, Wilson PWF,. Schaefer EJ, Ordovas

JM. Alcohol drinking determines the effect of the APOE locus on low-density lipoprotein

cholesterol concentrations in male subjects: The Framingham Offspring Study. Am. J.

Clin. Nutr. 2001 Apr;73(4):736-45.

269. Carmena-Ramon R, Ascaso JF, Real JT, Najera G, Ordovas JM, Carmena R. Association

between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus

and plasma lipoprotein levels in familial hypercholesterolemia. Metabolism 2001

Jun;50(6):651-6.

270. Pedro-Botet J, Schaefer EJ, Bakker-Arkema RG, Black DM, Stein EM, Corella D, Ordovas

JM Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender

specific manner. Atherosclerosis 2001,158(1):183-93.

271. Russo GT, Meigs JB, Cupples LA, Otvos JD, Wilson PWF, Lahoz C, Cucinotta D, Couture

P, Schaefer EJ, Ordovas JM association of the SST-I polymorphism at the APOC3 gene

locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart

disease risk: the Framingham Offspring Study. Atherosclerosis 2001 Sep;158(1):173-81.

272. Fuentes F, Lopez-Miranda J, Sanchez E, Sanchez F, Paez J, Paz-Rojas E, Marin C, Gomez

P, Jimenez-Pereperez J, Ordovas JM, Perez-Jimenez F. Mediterranean and Low-Fat Diets

Improve Endothelial Function in Hypercholesterolemic Men. Ann Intern Med. 2001 Jun

19;134(12):1115-1119.

41

273. Lyu LC, Yeh CY, Lichtenstein AH, Li Z, Ordovas JM, Schaefer EJ. Association of sex,

adiposity, and diet with HDL subclasses in middle-aged Chinese. Am J Clin Nutr. 2001

Jul;74(1):64-71.

274. Galluzzi JR, Cupples LA, Meigs JB, Wilson PW, Schaefer EJ, Ordovas JM. Association of

the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h

postchallenge insulin levels in the Framingham Offspring Study. Diabetes Care. 2001

Jul;24(7):1161-6.

275. Corella D, Guillén M, Sáiz C, Portolés O, Sabater A, Cortina S, Folch J, González JI,

Ordovas JM. Environmental factors modulate the effect of the APOE genetic

polymorphism on plasma lipid concentrations: Ecogenetic studies in a Mediterranean

Spanish population. Metabolism 2001 Aug;50(8):936-44.

276. Perez-Jimenez F, Lopez-Miranda J, Pinillos MD, Gomez P, Paz-Rojas E, Montilla P,

Marin C, Velasco MJ, Blanco-Molina A, Jimenez Pereperez JA, Ordovas JM. A

Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy

young persons. Diabetologia. 2001 Nov;44(11):2038-43

277. Perez-Martinez P, Gomez P, Paz E, Marin C, Gavilan Moral E, Lopez-Miranda J,

Ordovas JM, Fernandez de la Puebla RA, Perez-Jimenez F. Interaction between smoking

and the Sstl polymorphism of the apo C-III gene determines plasma lipid response to

diet. Nutr Metab Cardiovasc Dis. 2001 Aug;11(4):237-43.

278. Senti M, Elosua R, Tomas M, Sala J, Masia R, Ordovas JM, Shen H, Marrugat J. Physical

activity modulates the combined effect of a common variant of the lipoprotein lipase

gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol

in men. Hum Genet. 2001 Oct;109(4):385-92.

279. Ordovas JM. Cholesterol and tobacco: classics that withstand the passing of time. Rev

Esp Cardiol. 2001 Oct;54(10):1143-5.

280. Weggemans RM, Zock PL, Ordovas JM, Ramos-Galluzzi J, Katan MB. Genetic

polymorphisms and lipid response to dietary changes in humans. Eur J Clin Invest. 2001

Nov;31(11):950-7.

281. Galluzzi JR, Cupples LA, Otvos JD, Wilson PW, Schaefer EJ, Ordovas JM. Association of

the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in

42

plasma lipids in The Framingham Offspring Study. Atherosclerosis. 2001 Dec;159(2):417-

24.

282. Ordovas JM, Corella D, Cupples LA, Demissie S, Kelleher A, Coltell O, Wilson PW,

Schaefer EJ, Tucker K. Polyunsaturated fatty acids modulate the effects of the APOA1 G-

A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the

Framingham Study. Am J Clin Nutr. 2002 Jan;75(1):38-46.

283. Sanchez-Muniz FJ, Merinero MC, Rodriguez-Gil S, Ordovas JM, Rodenas S, Cuesta C.

Dietary Fat Saturation Affects Apolipoprotein AII Levels and HDL Composition in

Postmenopausal Women. J Nutr. 2002 Jan;132(1):50-54.

284. Ordovas JM, Shen H. Pharmacogenetics of Lipid-lowering Therapies. Curr Atheroscler

Rep. 2002 May;4(3):183-92.

285. Corella D, Guillen M, Saiz C, Portoles O, Sabater A, Folch J, Ordovas JM. Associations of

LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population.

Interaction with tobacco smoking and the apoe locus. J Lipid Res. 2002 Mar;43(3):416-

27.

286. Ordovas JM, Mooser V. The APOE locus and the pharmacogenetics of lipid response.

Curr Opin Lipidol. 2002 Apr;13(2):113-7.

287. Ordovas JM, Tai ES. The babel of the ABCs: novel transporters involved in the

regulation of sterol absorption and excretion. Nutr Rev. 2002 Jan;60(1):30-3.

288. Larson IA, Ordovas JM, Barnard JR, Hoffmann MM, Feussner G, Lamon-Fava S,

Schaefer EJ. Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein,

serum lipoprotein and glucose levels. Clin Genet. 2002 Mar;61(3):176-84.

289. Corella D, Guillen M, Saiz C, Portoles O, Sabater A, Folch J, Ordovas JM. Associations

of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population:

interaction with tobacco smoking and the APOE locus. J Lipid Res. 2002 Mar;43(3):416-

27.

290. Ordovas JM. Gene-diet interaction and plasma lipid responses to dietary intervention.

Biochem Soc Trans. 2002 Apr;30(2):68-73.

43

291. Tai ES, Demissie S, Cupples LA, Corella D, Wilson PW, Schaefer EJ, Ordovas JM.

Association between the PPARA L162V polymorphism and plasma lipid levels: the

Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):805-10.

292. Ordovas JM, Qi L, Shen H. Is IL12B a potential genetic target for the prevention of type

1 diabetes through dietary intervention? Nutr Rev. 2002 Jun;60(6):182-6.

293. Vargas-Martinez C, Ordovas JM, Wilson PW, Selhub J. The glutamate

carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the

Framingham Offspring cohort. J Nutr. 2002 Jun;132(6):1176-9.

294. Schaefer EJ, McNamara JR, Shah PK, Nakajima K, Cupples LA, Ordovas JM, Wilson PW.

Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and

women in the Framingham Offspring Study. Diabetes Care. 2002 Jun;25(6):989-94.

295. Ordovas JM, Corella D, Demissie S, Cupples LA, Couture P, Coltell O, Wilson PWF,

Schaefer EJ, Tucker KL. Dietary Fat Intake Determines the Effect of a Common

Polymorphism in the Hepatic Lipase Gene Promoter on High-Density Lipoprotein

Metabolism: Evidence of a Strong Dose Effect in This Gene-Nutrient Interaction in the

Framingham Study. Circulation 2002;106 2315-2321

296. Brousseau ME, O’Connor JJ Jr, Ordovas JM, Collins D, Otvos JD, Massov T, McNamara

JR, Rubins HB, Robins SJ, Schaefer EJ. Cholesteryl ester transfer protein TaqI B2B2

genotype is associated with higher HDL cholesterol levels and lower risk of coronary

heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol

Intervention Trial. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7): 1148-54.

297. Ordovas JM. HDL Genetics: Candidate Genes, Genome Wide Scans and Gene-

Environment Interactions. Cardiovasc Drugs Ther. 2002 Jul; 16(4):273-81.

298. Marin C, Lopez-Miranda J, Gomez P, Paz E, Perez-Martinez P, Fuentes F, Jimenez-

Pereperez JA, Ordovas JM, Perez-Jimenez F. Effects of the human apolipoprotein A-I

promoter G-A mutation on postprandial lipoprotein metabolism. Am J Clin Nutr. 2002

Aug;76(2):319-25.

299. Weggemans RM, Zock PL, Tai ES, Ordovas JM, Molhuizen HO, Katan MB. ATP binding

cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in

humans. Clin Genet. 2002 Sep;62(3):226-9.

44

300. Ordovas JM, Shen H Genetics, the environment, and lipid abnormalities. Curr Cardiol

Rep. 2002 Nov;4(6):508-13.

301. Perez-Martinez P, Ordovas JM, Lopez-Miranda J, Gomez P, Marin C, Moreno J,

Fuentes F, Fernandez de la Puebla RA, Perez-Jimenez F. Polymorphism exon 1 variant at

the locus of the scavenger receptor class B type I gene: influence on plasma LDL

cholesterol in healthy subjects during the consumption of diets with different fat

contents. Am J Clin Nutr. 2003 Apr;77(4):809-13.

302. Ordovas JM. The “game of life”: getting to know the players and their tactics. Nutr

Metab Cardiovasc Dis. 2002; 12:313-5.

303. Crott JW, Choi SW, Ordovas JM, Ditelberg JS, Mason JB. Effects of dietary folate and

aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis.

Carcinogenesis. 2003

304. Tai ES, Ordovas JM, Corella D, Deurenberg-Yap M, Chan E, Adiconis X, Chew SK, Loh

LM, Tan CE. The TaqIB and –629C>A polymorphisms at the cholesterol ester transfer

protein locus. Associations with lipid levels in a multi-ethnic population. The 1998

Singapore National Health Survey. Clin. Genet. 2003 Jan;63(1):19-30

305. Tai ES, Adiconis X, Ordovas JM, Carmena-Ramon R, Real J, Ascaso J, Carmena R.

Polymorphisms at the SRB1 locus are associated with lipoprotein levels in subjects with

heterozygous familial hypercholesterolemia. Clin. Genet. 2003 Jan;63(1):53-58.

306. Ordovas JM. Cardiovascular disease genetics: a long and winding road. Curr Opin

Lipidol. 2003 Feb; 14(1):47-54.

307. Mooser V, Ordovas JM. Editorial comment: ‘Omic’ approaches and lipid metabolism:

are these new technologies holding their promises? Curr Opin Lididol. 2003 Apr;

14(2):115-9.

308. Qi L, Shen H, Ordovas JM. Hearts and bones. Nutr Metab Cardiovasc Dis. 2003

Jun;13(3):165-74.

309. Marrugat J, D'Agostino R, Sullivan L, Elosua R, Wilson P, Ordovas J, Solanas P, Cordon

F, Ramos R, Sala J, Masia R, Kannel WB. An adaptation of the Framingham coronary

heart disease risk function to European Mediterranean areas. J Epidemiol Community

Health. 2003;57:634-8.

45

310. Ordovas J, Pittas A, Greenberg AS. Might the diabetic environment in utero lead to

type 2 diabetes? Lancet. 2003 May 31;361(9372):1839-40.

311. Osgood D, Corella D, Demissie S, Cupples LA, Wilson PW, Meigs JB, Schaefer EJ, Coltell

O, Ordovas JM. Genetic variation at the scavenger receptor class B type I gene locus

determines plasma lipoprotein concentrations and particle size and interacts with type

2 diabetes: the framingham study. J Clin Endocrinol Metab. 2003 Jun;88(6):2869-79.

312. Kim MK, Ordovas JM, Selhub J, Campos H. B vitamins and plasma homocysteine

concentrations in an urban and rural area of Costa Rica. J Am Coll Nutr. 2003

Jun;22(3):224-31.

313. Marrugat J, D'Agostino R, Sullivan L, Elosua R, Wilson P, Ordovas J, Solanas P, Cordon

F, Ramos R, Sala J, Masia R, Kannel WB. An adaptation of the Framingham coronary

heart disease risk function to European Mediterranean areas. J Epidemiol Community

Health. 2003 Aug; 57(8): 634-8.

314. Brown S, Ordovas JM, Campos H. Interaction between the APOC3 gene promoter

polymorphisms, saturated fat intake and plasma lipoproteins. Atherosclerosis. 2003 Oct;

170(2): 307-13.

315. Tan CE, Tai ES, Tan CS, Chia KS, Lee J, Chew SK, Ordovas JM. APOE polymorphism and

lipid profile in three ethnic groups in the Singapore population. Atherosclerosis. 2003

Oct; 170(2): 253-60.

316. Li Z, Otvos JD, Lamon-Fava S, Carrasco WV, Lichtenstein AH, McNamara JR,Ordovas

JM, Schaefer EJ. Men and women differ in lipoprotein response to dietary saturated fat

and cholesterol restriction. J Nutr. 2003 Nov; 133(11): 3428-33.

317. Russo GT, Friso S, Jacques PF, Rogers G, Cucinotta D, Wilson PW, Ordovas JM,

Rosenberg IH, Selhub J. Age and gender affect the relation between

methylenetetrahydrofolate reductase C677T genotype and fasting plasma

homocysteine concentrations in the Framingham Offspring Study Cohort. J Nutr. 2003

Nov; 133(11): 3416-21.

318. Tai ES, Corella D, Deurenberg-Yap M, Cutter J, Chew SK, Tan CE, Ordovas JM. Dietary

fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on

plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National

Health Survey. J Nutr. 2003 Nov; 133(11): 3399-408.

46

319. Moreno JA, Lopez-Miranda J, Marin C, Gomez P, Perez-Martinez P, Fuentes F,

Fernandez de la Puebla RA, Paniagua JA, Ordovas JM, Perez-Jimenez F. The influence of

the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial

lipoprotein metabolism in young normolipemic males. J Lipid Res. 2003 Nov; 44(11):

2059-64.

320. Elosua R, Demissie S, Cupples LA, Meigs JB, Wilson PW, Schaefer EJ, Corella D, Ordovas

JM. Obesity Modulates the Association among APOE Genotype, Insulin, and Glucose in

Men. Obes Res. 2003 Dec; 11(12): 1502-1508.

321. Jang Y, Kim OY, Ryu HJ, Kim JY, Song SH, Ordovas JM, Lee JH. Visceral fat accumulation

determines postprandial lipemic response, lipid peroxidation, DNA damage, and

endothelial dysfunction in nonobese Korean men. J Lipid Res. 2003 Dec; 44(12): 2356-

64.

322. Lai CQ, Tai ES, Tan CE, Cutter J, Chew SK, Zhu YP, Adiconis X, Ordovas JM. The APOA5

locus is a strong determinant of plasma triglyceride concentrations across ethnic groups

in Singapore. J Lipid Res. 2003 Dec; 44(12): 2365-73.

323. Jang Y, Kim OY, Ryu HJ, Kim JY, Song SH, Ordovas JM, Lee JH. Visceral fat accumulation

determines postprandial lipemic response, lipid peroxidation, DNA damage, and

endothelial dysfunction in nonobese Korean men. J Lipid Res. 2003 Dec;44(12):2356-64.

Epub 2003 Sep 01.

324. Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ. ATP binding

cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and

after treatment with atorvastatin. J Lipid Res. 2004

325. Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. CYP3A4 genotypes and plasma

lipoprotein levels before and after treatment with atorvastatin in primary

hypercholesterolemia. Am J Cardiol. 2004 Jan 1; 93(1): 104-7.

326. Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ. ATP binding

cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and

after treatment with atorvastatin. J Lipid Res. 2004 Apr;45(4):653-6. Epub 2004 Jan 01

327. Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. CYP3A4 genotypes and plasma

lipoprotein levels before and after treatment with atorvastatin in primary

hypercholesterolemia. Am J Cardiol. 2004 Jan 1;93(1):104-7.

47

328. Fox CS, Cupples LA, Chazaro I, Polak JF, Wolf PA, D'Agostino RB, Ordovas JM,

O'Donnell CJ. Genomewide linkage analysis for internal carotid artery intimal medial

thickness: evidence for linkage to chromosome 12. Am J Hum Genet. 2004

Feb;74(2):253-61. Epub 2004 Jan 16.

329. Qi L, Shen H, Larson I, Barnard JR, Schaefer EJ, Ordovas JM. Genetic variation at the

hormone sensitive lipase: gender-specific association with plasma lipid and glucose

concentrations. Clin Genet. 65(2): 93-100, February 2004

330. Perez-Martinez P, Lopez-Miranda J, Ordovas JM, Bellido C, Marin C, Gomez P,

Paniagua JA, Moreno JA, Fuentes F, Perez-Jimenez F. Postprandial lipemia is modified by

the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus.

J Mol Endocrinol. 32(1): 237-45, February 2004

331. Pereira MA, Weggemans RM, Jacobs DR Jr, Hanan PJ, Zock PL, Ordovas JM, Katan MB.

Within-person variation in serum lipids: implications for clinical trials. Int J Epidemiol.

2004 Mar 11 [Epub ahead of print]

332. McLean RR, Karasik D, Selhub J, Tucker KL, Ordovas JM, Russo GT, Cupples LA, Jacques

PF, Kiel DP. Association of a common polymorphism in the methylenetetrahydrofolate

reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.

Journal of Bone and Mineral Research. 19(3): 410-8, March 2004

333. Ordovas JM, Mooser V. Nutrigenomics and nutrigenetics. Curr Opin Lipidol. 15(2): 101-

108, April 2004

334. Tai ES, Corella D, Deurenberg-Yap M, Adiconis X, Chew SK, Tan CE, Ordovas JM.

Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma

lipids and diabetes risk in an Asian population. J Lipid Res. 45(4): 674-685, April 2004

335. Ganan A, Corella D,Guillen M,Ordovas JM,Pocovi M. Frequencies of Apolipoprotein A4

Gene Polymorphisms and Association With Serum Lipid Concentrations in Two Healthy

Spanish Populations. Human Biology; An International Record of Research. 76(2): 253-

66, Apr 2004

336. Corella D, Ordovas JM. The metabolic syndrome: a crossroad for genotype-phenotype

associations in atherosclerosis. Curr Atheroscler Rep. 6(3): 186-96, 2004

48

337. Ordovas JM, Corella D. Nutritional Genomics. Annu Rev Genomics Hum Genet.

2004;5:71-118.

338. Tsai MY,Georgopoulos A,Otvos JD,Ordovas JM,Hanson NQ,Peacock JM,Arnett DK.

Comparison of Ultracentrifugation and Nuclear Magnetic Resonance Spectroscopy in

the Quantification of Triglyceride-rich Lipoproteins After An Oral Fat Load. Clinical

Chemistry. 50(7): 1201-4, Jul 2004

339. Kajinami K,Brousseau ME,Ordovas JM,Schaefer EJ. Interactions Between Common

Genetic Polymorphisms in ABCG5/G8 and CYP7A1 on LDL Cholesterol-lowering

Response to Atorvastatin. Atherosclerosis. 175(2): 287-93, Aug 2004

340. Brousseau ME,Goldkamp AL,Collins D,Demissie S,Connolly AC,Cupples LA,Ordovas

JM,Bloomfield HE,Robins SJ,Schaefer EJ. Polymorphisms in the Gene Encoding

Lipoprotein Lipase in Men With Low HDL-C and Coronary Heart Disease: the Veterans

Affairs HDL Intervention Trial. Journal of Lipid Research. 45(10): 1885-91, Oct 2004

341. Jang Y,Kim JY,Kim OY,Lee JE,Cho H,Ordovas JM,Lee JH. The -1131T-->C Polymorphism

in the Apolipoprotein A5 Gene Is Associated With Postprandial

Hypertriacylglycerolemia; Elevated Small, Dense LDL Concentrations; and Oxidative

Stress in Nonobese Korean Men. American Journal of Clinical Nutrition. 80(4): 832-40,

Oct 2004

342. Lopez-Miranda J, Cruz G, Gomez P, Marin C, Paz E, Perez-Martinez P, Fuentes FJ,

Ordovas JM, Perez-Jimenez F. The influence of lipoprotein lipase gene variation on

postprandial lipoprotein metabolism. J Clin Endocrinol Metab. 2004 Sep;89(9):4721-8

343. Qi L,Corella D,Sorli JV,Portoles O,Shen H,Coltell O,Godoy D,Greenberg AS,Ordovas JM.

Genetic Variation at the Perilipin (PLIN) Locus is Associated with Obesity-related

Phenotypes in White Women. Clinical Genetics. 66(4): 299-310, Oct 2004

344. Lai CQ, Demissie S,Cupples LA,Zhu Y,Adiconis X,Parnell LD,Corella D,Ordovas JM.

Influence of the APOA5 Locus on Plasma Triglyceride, Lipoprotein Subclasses, and CVD

Risk in the Framingham Heart Study. Journal of Lipid Research. 45(11): 2096-105, Nov

2004

345. Brousseau ME, Goldkamp AL, Collins D, Demissie S, Connolly AC, Cupples LA, Ordovas

JM, Bloomfield HE, Robins SJ, Schaefer EJ. Polymorphisms in the gene encoding

49

lipoprotein lipase in men with low HDL-C and coronary heart disease: The Veterans

Affairs HDL Intervention Trial. J Lipid Res. 2004;45:1885-9.

346. Elosua R, Ordovas JM, Cupples LA, Fox CS, Polak JF, Wolf PA, D'Agostino RA Sr,

O'Donnell CJ. Association of APOE genotype with carotid atherosclerosis in men and

women: the Framingham Heart Study. J Lipid Res. 2004;45:1868-75.

347. Li Z, Lamon-Fava S, Otvos J, Lichtenstein AH, Velez-Carrasco W, McNamara JR,

Ordovas JM, Schaefer EJ. Fish consumption shifts lipoprotein subfractions to a less

atherogenic pattern in humans. J Nutr. 2004;134:1724-8.

348. Lee J, Tan CS, Chia KS, Tan CE, Chew SK, Ordovas JM, Tai ES. The lipoprotein lipase

S447X polymorphism and plasma lipids: interactions with APOE polymorphisms,

smoking, and alcohol consumption. J Lipid Res. 45(6): 1132-9, 2004

349. Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. Polymorphisms in the multidrug

resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-

specific manner. Am J Cardiol. 93(8): 1046-50, 2004

350. Ordovas JM. The quest for cardiovascular health in the genomic era: nutrigenetics

and plasma lipoproteins. Proc Nutr Soc. 2004;63:145-52.

351. Ordovas JM, and Corella D. Genes, Diets and Plasma Lipids: The Evidence from

Observational Studies. World Review of Nutrition and Dietetics Vol. 93. A.P. Simopoulos

and J.M. Ordovas, Editors. Karger (Basel). (2004), pp. 41-76.

352. Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Vitamin E and Gene

Expression in Immune Cells. Annals of the New York Academy of Sciences. 1031: 96-101,

Dec 2004

353. Sonnenberg L, Pencina M, Kimokoti R, Quatromoni P, Nam BH, D'Agostino R, Meigs JB,

Ordovas J, Cobain M, Millen B. Dietary Patterns and the Metabolic Syndrome in Obese

and Non-obese Framingham Women. Obesity Research. 13(1): 153-62, Jan 2005

354. Kajinami K, Brousseau ME, Lamon-Fava S,. Gender-specific Effects of Estrogen

Receptor Alpha Gene Haplotype on High-density Lipoprotein Cholesterol Response to

Atorvastatin: Interaction with Apolipoprotein AI Gene Polymorphism. Atherosclerosis.

178(2): 331-8, Feb 2005

50

355. Qi L, Tai ES, Tan CE, Shen H, Chew SK, G. Intragenic Linkage Disequilibrium Structure of

the Human Perilipin Gene (PLIN) and Haplotype Association With Increased Obesity Risk

in a Multiethnic Asian Population. J Mol Med. Mar 2005

356. Tai ES,Corella D,Demissie S,Cupples LA,Coltell O,Schaefer EJ,Tucker KL,Ordovas

JM,Framingham heart study. Polyunsaturated Fatty Acids Interact With the PPARA-

L162V Polymorphism To Affect Plasma Triglyceride and Apolipoprotein C-III

Concentrations in The Framingham Heart Study. Journal of Nutrition. 135(3): 397-403,

Mar 2005

357. Cendoroglo MS, Lahoz C, Martinez TL, Ordovas JM, Lamon-Fava S, Cupples LA, Wilson

PW, Schaefer EJ. Association of Apo A-IV 360 (Gln --> His) Polymorphism With Plasma

Lipids and Lipoproteins: the Framingham Offspring Study. Atherosclerosis. 179(1): 169-

75, Mar 2005

358. Perez-Martinez P, Perez-Jimenez F, Belli. A Polymorphism Exon 1 Variant At the Locus

of the Scavenger Receptor Class B Type I (SCARB1) Gene Is Associated With Differences

in Insulin Sensitivity in Healthy People During the Consumption of An Olive Oil-Rich Diet.

J Clin Endocrinol Metab. 90(4): 2297-300, Published, Apr 2005

359. Ordovas JM,Mooser V. Genes, Lipids and Aging: Is It All Accounted for By

Cardiovascular Disease Risk?: Editorial Review. Current Opinion in Lipidology. 16(2): 121-

6, Apr 2005

360. Lai CQ,Parnell LD,Ordovas JM. The APOA1/C3/A4/A5 Gene Cluster, Lipid Metabolism

and Cardiovascular Disease Risk. Current Opinion in Lipidology. 16(2): 153-66, Apr 2005

361. DeBusk RM,Fogarty CP,Ordovas JM,Kornman KS. Nutritional Genomics in Practice:

Where Do We Begin? Journal American Dietetic Association. 105(4): 589-98, Apr 2005

362. Ordovas JM. HDL cholesterol: second annual meeting metabolic pathways and drug

development. IDrugs. 2001 May;4(5):529-32.

363. Elosua R, Bartali B, Ordovas JM, Corsi AM, Lauretani F, Ferrucci L; InCHIANTI

Investigators. Association between physical activity, physical performance, and

inflammatory biomarkers in an elderly population: the InCHIANTI study. J Gerontol A

Biol Sci Med Sci. 2005 Jun;60(6):760-7.

51

364. Tsai MY, Hanson NQ, Straka RJ, Hoke TR, Ordovas JM, Peacock JM, Arends VL, Arnett

DK. Effect of influenza vaccine on markers of inflammation and lipid profile. J Lab Clin

Med. 2005 Jun;145(6):323-7.

365. Kajinami K,Brousseau ME,Ordovas JM,Schaefer EJ. A Promoter Polymorphism in

Cholesterol 7alpha-hydroxylase Interacts With Apolipoprotein E Genotype in the LDL-

lowering Response To Atorvastatin. Atherosclerosis. 180(2): 407-15, Jun 2005

366. Yang Q,Lai CQ, Parnell L, Cupples LA, Adiconis. Genome-wide Linkage Analyses and

Candidate Gene Fine Mapping for HDL3 Cholesterol: the Framingham Study. J Lipid Res.

2005 Jul;46(7):1416-25. Epub 2005 Apr 1.

367. Ruano G, Seip RL, Windemuth A, Zollner S, Tsongalis GJ, Ordovas J, Otvos J, Bilbie C,

Miles M, Zoeller R, Visich P, Gordon P, Angelopoulos TJ, Pescatello L, Moyna N,

Thompson PD. Apolipoprotein A1 genotype affects the change in high density

lipoprotein cholesterol subfractions with exercise training. Atherosclerosis. 2005 Jul 6;

[Epub ahead of print]

368. Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH,

Housman DE, Mendelsohn ME, Ordovas JM. Estrogen receptor-alpha variants are

associated with lipoprotein size distribution and particle levels in women: The

Framingham Heart Study. Atherosclerosis. 2005 Jul 6; [Epub ahead of print]

369. Millen BE, Quatromoni PA, Nam BH, Pencina MJ, Polak JF, Kimokoti RW, Ordovas JM,

D'Agostino RB. Compliance with expert population-based dietary guidelines and lower

odds of carotid atherosclerosis in women: the Framingham Nutrition Studies. Am J Clin

Nutr. 2005 Jul;82(1):174-80.

370. Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn

ME, Housman DE. Tobacco smoking, estrogen receptor alpha gene variation and small

low density lipoprotein level. Hum Mol Genet. 2005 Aug 15;14(16):2405-13.

371. Corella D, Qi L, Sorli JV, Godoy D, Portoles O, Coltell O, Greenberg AS, Ordovas JM.

Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant

to weight loss after dietary energy restriction. J Clin Endocrinol Metab. 2005

Sep;90(9):5121-6.

52

372. Ordovas L, Roy R, Zaragoza P, Hayes H, Eggen A, Rodellar C. Assignment of the solute

carrier family 27 member 1 (SLC27A1) gene to bovine chromosome 7. Anim Genet.

2005Aug;36(4):352-3.

373. Corella D, Ordovas JM. Single nucleotide polymorphisms that influence lipid

metabolism: Interaction with Dietary Factors. Annu Rev Nutr. 2005;25:341-90.

374. Tai ES, Collins D, Robins SJ, O'connor JJ Jr, Bloomfield HE, Ordovas JM,Schaefer EJ,

Brousseau ME. The L162V polymorphism at the peroxisome proliferator activated

receptor alpha locus modulates the risk of cardiovascular events associated with insulin

resistance and diabetes mellitus: The Veterans Affairs HDL Intervention Trial (VA-HIT).

Atherosclerosis. 2005 Oct 8; [Epub ahead of print]

375. Jang Y, Lee JH, Chae JS, Kim OY, Koh SJ, Kim JY, Cho H, Lee JE, Ordovas JM. Association

of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk

factors in nondiabetic Koreans. Am J Clin Nutr. 2005 Oct;82(4):760-7.

376. Ordovas JM. Diet-heart hypothesis: will diversity bring reconciliation? Am J Clin Nutr.

2005 Nov;82(5):919-20.

377. Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN,

Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R,

van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S,

Clement K, Cooney CA, Corella D, Manica da Cruz IB, Daniel H, Duster T, Ebbesson SO,

Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison

R, Gibney MJ, Gillies PJ, Gustafsson JA, Hartman Iv JL, He L, Hwang JK, Jais JP, Jang Y,

Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW,

Langin D, Lauren DR, Ho Lee J, Leveille GA, Lin SJ, Mathers J, Mayne M, McNabb W,

Milner JA, Morgan P, Muller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-

Jimenez F, Poutanen K, Roberts M, Saris WH, Schuster G, Shelling AN, Simopoulos AP,

Southon S, Tai ES, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke

J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker JD. The case for strategic international

alliances to harness nutritional genomics for public and personal health. Br J Nutr. 2005

Nov;94(5):623-32.

378. Talmud PJ, Stephens JW, Hawe E, Demissie S, Cupples LA, Hurel SJ, Humphries SE,

Ordovas JM. The significant increase in cardiovascular disease risk in APOEepsilon4

53

carriers is evident only in men who smoke: potential relationship between reduced

antioxidant status and ApoE4. Ann Hum Genet. 2005 Nov;69(Pt 6):613-22.

379. Millen BE, Quatromoni PA, Pencina M, Kimokoti R, Nam BH, Cobain S, Kozak W,

Appugliese DP, Ordovas J, D'Agostino RB. Unique dietary patterns and chronic disease

risk profiles of adult men: the Framingham nutrition studies. J Am Diet Assoc. 2005

Nov;105(11):1723-34.

380. Ordovas JM, Corella D. Genetic variation and lipid metabolism: modulation by dietary

factors. Curr Cardiol Rep. 2005 Nov;7(6):480-6

381. Roy R, Ordovas L, Taourit S, Zaragoza P, Eggen A, Rodellar C. Genomic structure and an

alternative transcript of bovine mitochondrial glycerol-3-phosphate acyltransferase

gene (GPAM). Cytogenet Genome Res. 2006;112(1-2):82-9.

382. Corella D, Ordovas JM. Integration of environment and disease into 'omics' analysis.

Curr Opin Mol Ther. 2005 Dec;7(6):569-76. Review.

383. Herron KL, Lofgren IE, Adiconis X, Ordovas JM, Fernandez ML. Associations between

plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are

independent of dietary cholesterol intake. Atherosclerosis. 2006 Jan;184(1):113-20.

Epub 2005 Apr 21.

384. Jang Y, Lee JH, Kim OY, Koh SJ, Chae JS, Woo JH, Cho H, Lee JE, Ordovas JM.The

SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated

with insulin resistance and cardiovascular disease risk than SNP45T>G in

nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating

plasma adiponectin. Metabolism. 2006 Jan;55(1):59-66.

385. Elosua R, Cupples LA, Fox CS, Polak JF, D'Agostino RA Sr, Wolf PA, O'donnell CJ,

Ordovas JM. Association between well-characterized lipoprotein-related genetic

variants and carotid intimal medial thickness and stenosis: The Framingham Heart

Study. Atherosclerosis. 2006 Jan 20; [Epub ahead of print]

386. Thompson PD, Tsongalis GJ, Ordovas JM, Seip RL, Bilbie C, Miles M, Zoeller R, Visich P,

Gordon P, Angelopoulos TJ, Pescatello L, Moyna N. Angiotensin-converting enzyme

genotype and adherence to aerobic exercise training. Prev Cardiol. 2006 Winter;9(1):21-

4.

54

387. Elosua R, Ordovas JM, Cupples LA, Lai CQ, Demissie S, Fox CS, Polak JF, Wolf PA,

D'Agostino RA, O'donnell CJ. Variability at the APOA5 locus is associated with carotid

atherosclerosis with a modifying effect of obesity: the Framingham Heart Study. J Lipid

Res. 2006 Feb 11; [Epub ahead of print]

388. Duff GW, Libby P, Ordovas JM, Reilly PR. The future of living well to 100. Am J Clin

Nutr. 2006 Feb;83(2):488S-490S. Review.

389. Ordovas JM. Genetic interactions with diet influence the risk of cardiovascular

disease.Am J Clin Nutr. 2006 Feb;83(2):443S-446S. Review.

390. Shin MJ, Jang Y, Koh SJ, Chae JS, Kim OY, Lee JE, Ordovas JM, Lee JH. The association of

SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in

response to mild weight loss. Int J Obes (Lond). 2006 Apr 11; [Epub ahead of print]

391. Jang Y, Kim OY, Lee JH, Koh SJ, Chae JS, Kim JY, Park S, Cho H, Lee JE, Ordovas JM.

Genetic variation at the perilipin locus is associated with changes in serum free fatty

acids and abdominal fat following mild weight loss. Int J Obes (Lond). 2006 Apr 4; [Epub

ahead of print]

392. Ordovas JM, Mooser V. Metagenomics: the role of the microbiome in cardiovascular

diseases. Curr Opin Lipidol. 2006 Apr;17(2):157-61.

393. Herron KL, McGrane MM, Waters D, Lofgren IE, Clark RM, Ordovas JM, Fernandez ML.

The ABCG5 Polymorphism Contributes to Individual Responses to Dietary Cholesterol

and Carotenoids in Eggs. J Nutr. 2006 May;136(5):1161-5.

394. Ordovas JM. Nutrigenetics, plasma lipids, and cardiovascular risk. J Am Diet Assoc.

2006 Jul;106(7):1074-81.

395. Lievers KJ, Kluijtmans LA, Blom HJ, Wilson PW, Selhub J, Ordovas JM. Association of a

31 bp VNTR in the CBS gene with postload homocysteine concentrations in the

Framingham Offspring Study. Eur J Hum Genet. 2006 Jun 21; [Epub ahead of print]

396. Jang Y, Yoen Kim O, Jeong Koh S, Sook Chae J, Kuk Goh Y, Young Kim J, Cho H, Jeong

TS, Song Lee W, Ordovas JM, Ho Lee J. The Val279Phe variant of the lipoprotein-

associated phospholipase A2 gene is associated with catalytic activities and

cardiovascular disease in Korean men. J Clin Endocrinol Metab. 2006 Jun 20;

55

397. Shen H, Qi L, Tai ES, Chew SK, Tan CE, Ordovas JM. Uncoupling protein 2 promoter

polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians. Obesity

(Silver Spring). 2006 Apr;14(4):656-61.

398. Corella D, Qi L, Tai ES, Deurenberg-Yap M, Tan CE, Chew SK, Ordovas JM. Perilipin

gene variation determines higher susceptibility to insulin resistance in Asian women

when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 2006

Jun;29(6):1313-9.

399. Scott TM, Peter I, Tucker KL, Arsenault L, Bergethon P, Bhadelia R, Buell J, Collins L,

Dashe JF, Griffith J, Hibberd P, Leins D, Liu T, Ordovas JM, Patz S, Price LL, Qiu WQ,

Sarnak M, Selhub J, Smaldone L, Wagner C, Wang L, Weiner D, Yee J, Rosenberg I,

Folstein M. The Nutrition, Aging, and Memory in Elders (NAME) study: design and

methods for a study of micronutrients and cognitive function in a homebound elderly

population. Int J Geriatr Psychiatry. 2006 Jun;21(6):519-28.

400. Lai CQ, Corella D, Demissie S, Cupples LA, Adiconis X, Zhu Y, Parnell LD,Tucker KL,

Ordovas JM. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5

gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and

lipoprotein particle size: the Framingham Heart Study. Circulation. 2006 May

2;113(17):2062-70.

401. Georgopoulos A, Bloomfield H, Collins D, Brousseau ME, Ordovas JM, O'connor JJ,

Robins SJ, Schaefer EJ. Codon 54 polymorphism of the fatty acid binding protein (FABP)

2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic

participants of the veterans affairs HDL intervention trial (VA-HIT). Atherosclerosis. 2006

Aug 28; [Epub ahead of print]

402. Kim JY, Kim OY, Koh SJ, Jang Y, Yun SS, Ordovas JM, Lee JH. Comparison of Low-Fat

Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according

to the -1131T>C Polymorphism of the apolipoprotein A5 (APOA5) Gene. J Am Coll Nutr.

2006 Aug;25(4):340-7.

403. Millen BE, Pencina MJ, Kimokoti RW, Zhu L, Meigs JB, Ordovas JM, D'Agostino RB.

Nutritional risk and the metabolic syndrome in women: opportunities for preventive

intervention from the Framingham Nutrition Study. Am J Clin Nutr. 2006 Aug;84(2):434-

41.

56

404. Guo CY, Lunetta KL, Destefano AL, Ordovas JM, Adrienne Cupples L. Informative-

Transmission Disequilibrium Test (i-TDT): combined linkage and association mapping

that includes unaffected offspring as well as affected offspring. Genet Epidemiol. 2006

Nov 22; [Epub ahead of print]

405. Yiannakouris N, Trichopoulou A, Benetou V, Psaltopoulou T, Ordovas JM, Trichopoulos

D. A direct assessment of genetic contribution to the incidence of coronary infarct in the

general population Greek EPIC cohort. Eur J Epidemiol. 2006 Nov 22; [Epub ahead of

print]

406. Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Age and vitamin E-

induced changes in gene expression profiles of T cells. J Immunol. 2006 Nov

1;177(9):6052-61.

407. Georgopoulos A, Bloomfield H, Collins D, Brousseau ME, Ordovas JM, O'connor JJ,

Robins SJ, Schaefer EJ. Codon 54 polymorphism of the fatty acid binding protein (FABP)

2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic

participants of the veterans affairs HDL intervention trial (VA-HIT). Atherosclerosis. 2006

Aug 28; [Epub ahead of print]

408. Kim JY, Kim OY, Koh SJ, Jang Y, Yun SS, Ordovas JM, Lee JH. Comparison of low-fat

meal and high-fat meal on postprandial lipemic response in non-obese men according

to the -1131T>C polymorphism of the apolipoprotein A5 (APOA5) gene (randomized

cross-over design). J Am Coll Nutr. 2006 Aug;25(4):340-7.

409. Lai CQ, Parnell LD, Lyman RF, Ordovas JM, Mackay TF. Candidate genes affecting

Drosophila life span identified by integrating microarray gene expression analysis and

QTL mapping. Mech Ageing Dev. 2007 Mar;128(3):237-49.

410. Corella D, Lai CQ, Demissie S, Cupples LA, Manning AK, Tucker KL, Ordovas JM. APOA5

gene variation modulates the effects of dietary fat intake on body mass index and

obesity risk in the Framingham Heart Study. J Mol Med. 2007 Feb;85(2):119-28.

411. Perez-Martinez P, Perez-Jimenez F, Ordovas JM, Bellido C, Moreno JA, Gomez P, Marin

C, Fernandez de la Puebla RA, Paniagua JA, Lopez-Miranda J. The APOB -516C/T

polymorphism has no effect on lipid and apolipoprotein response following changes in

dietary fat intake in a healthy population. Nutr Metab Cardiovasc Dis. 2007

Mar;17(3):224-9.

57

412. Tanaka T, Ordovas JM, Delgado-Lista J, Perez-Jimenez F, Marin C, Perez-Martinez P,

Gomez P, Lopez-Miranda J. Peroxisome proliferator-activated receptor alpha

polymorphisms and postprandial lipemia in healthy men. J Lipid Res. 2007 Mar 15;

413. Moreno R, Perez-Jimenez F, Marin C, Perez-Martinez P, Gomez P, Jimenez-Gomez Y,

Delgado-Lista J, Moreno JA, Tanaka T, Ordovas JM, Lopez-Miranda J. Two independent

apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a

healthy Caucasian population. J Clin Endocrinol Metab. 2007 Mar 13;

414. Tai ES, Ordovas JM. The role of perilipin in human obesity and insulin resistance. Curr

Opin Lipidol. 2007 Apr;18(2):152-156.

415. Perez-Martinez P, Perez-Jimenez F, Ordovas JM, Moreno JA, Moreno R, Fuentes F,

Ruano J, Gomez P, Marin C, Lopez-Miranda J. The APOB -516C/T polymorphism is

associated with differences in insulin sensitivity in healthy males during the

consumption of diets with different fat content. Br J Nutr. 2007 Apr;97(4):622-7.

416. Tanaka T, Delgado-Lista J, Lopez-Miranda J, Perez-Jimenez F, Marin C, Perez-Martinez

P, Gomez P, Ordovas JM. Scavenger Receptor Class B Type I (SCARB1) c.1119C>T

Polymorphism Affects Postprandial Triglyceride Metabolism in Men.

417. Laclaustra M, Corella D, Ordovas JM. Metabolic syndrome pathophysiology: the role

of adipose tissue. Nutr Metab Cardiovasc Dis. 2007 Feb;17(2):125-39.

418. Perez-Martinez P, Perez-Jimenez F, Ordovas JM, Moreno JA, Marin C, Moreno R,

Jimenez-Gomez Y, Paniagua JA, Lopez-Miranda J. Postprandial Lipemia is Modified by

the Presence of the APOB-516C/T Polymorphism in a Healthy Caucasian Population.

Lipids. 2007 Mar;42(2):143-50.

419. Ordovas JM. Identification of a functional polymorphism at the adipose fatty acid

binding protein gene (FABP4) and demonstration of its association with cardiovascular

disease: a path to follow. Nutr Rev. 2007 Mar;65(3):130-4.

420. Lai CQ, Arnett DK, Corella D, Straka RJ, Tsai MY, Peacock JM, Adiconis X, Parnell LD,

Hixson JE, Province MA, Ordovas JM. Fenofibrate Effect on Triglyceride and Postprandial

Response of Apolipoprotein A5 Variants. The GOLDN Study. Arterioscler Thromb Vasc

Biol. 2007 Apr 12;

58

421. Corella D, Arnett DK, Tsai MY, Kabagambe EK, Peacock JM, Hixson JE, Straka RJ,

Province M, Lai CQ, Parnell LD, Borecki I, Ordovas JM. The -256T>C Polymorphism in the

Apolipoprotein A-II Gene Promoter Is associated with Body Mass Index and Food Intake

in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clin Chem. 2007

Jun;53(6):1144-52.

422. Franco OH, Kirkwood TB, Powell JR, Catt M, Goodwin J, Ordovas JM, van der Ouderaa

F. Ten commandments for the future of ageing research in the UK: a vision for action.

BMC Geriatr. 2007 May 3;7:10.

423. Jang Y, Chae JS, Hyun YJ, Koh SJ, Kim JY, Ko MJ, Rim SJ, Shin HJ, Ordovas JM, Lee JH.

The RANTES -403G>A promoter polymorphism in Korean men: association with serum

RANTES concentration and coronary artery disease. Clin Sci (Lond). 2007 Oct;113(8):349-

56.

424. Shen J, Arnett DK, Peacock JM, Parnell LD, Kraja A, Hixson JE, Tsai MY, Lai CQ,

Kabagambe EK, Straka RJ, Ordovas JM. Interleukin1beta genetic polymorphisms interact

with polyunsaturated fatty acids to modulate risk of the metabolic syndrome. J Nutr.

2007 Aug;137(8):1846-51.

425. Ordovas JM, Corella D, Kaput J. Nutrient-gene interactions in lipoprotein metabolism -

an overview. Forum Nutr. 2007;60:102-9.

426. Delgado-Lista J, Perez-Jimenez F, Tanaka T, Perez-Martinez P, Jimenez-Gomez Y, Marin

C, Ruano J, Parnell L, Ordovas JM, Lopez-Miranda J. An apolipoprotein A-II

polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat

overload in healthy men. J Nutr. 2007 Sep;137(9):2024-8.

427. Santosa S, Demonty I, Lichtenstein AH, Ordovas JM, Jones PJ. Single nucleotide

polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol

metabolism during weight loss. J Lipid Res. 2007 Sep 7

428. Ordovas JM, Kaput J, Corella D. Nutrition in the genomics era: cardiovascular disease

risk and the Mediterranean diet. Mol Nutr Food Res. 2007 Oct;51(10):1293-9.

429. Pérez-Martínez P, Adarraga-Cansino MD, Fernández de la Puebla RA, Blanco-Molina A,

Delgado-Lista J, Marín C, Ordovás JM, López-Miranda J,Pérez-Jiménez F. The -675 4G/5G

polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma

59

Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat

consumption. Br J Nutr. 2007 Oct 1;:1-4

430. Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB Sr, Dawson-Hughes

B,Ordovas JM, O'Donnell CJ, Kathiresan S, Keaney JF Jr, Vasan RS, Benjamin EJ. Vitamin K

and Vitamin D Status: Associations with Inflammatory Markers in the Framingham

Offspring Study. Am J Epidemiol. 2007 Nov 15;

431. Kabagambe EK, Tsai MY, Hopkins PN, Ordovas JM, Peacock JM, Borecki IB, Arnett DK.

Erythrocyte Fatty Acid Composition and the Metabolic Syndrome: A National Heart,

Lung, and Blood Institute GOLDN Study. Chem Clin. 2007 Nov 12; [Epub ahead of print].

432. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB Sr, Ordovas

JM, O'Donnell CJ, Dawson-Hughes B, Vasan RS, Booth SL. Genetic and non-genetic

correlates of vitamins K and D. Eur J Clin Nutr. 2007 Nov 21; [Epub ahead of print]

433. Kathiresan S, Manning AK, Demissie S, D'Agostino RB, Surti A, Guiducci C, Gianniny L,

Burtt NP, Melander O, Orho-Melander M, Arnett DK, Peloso GM, Ordovas JM, Cupples

LA. A genome-wide association study for blood lipid phenotypes in the Framingham

Heart Study. BMC Med Genet. 2007 Sep 19;8 Suppl 1:S17.

434. Lai CQ, Leips J, Zou W, Roberts JF, Wollenberg KR, Parnell LD, Zeng ZB, Ordovas JM,

Mackay TF. Speed-mapping quantitative trait loci using microarrays. Nat Methods. 2007

Oct;4(10):839-41.

435. Antonia Trichopoulou A, Yiannakouris N, Bamia C, Benetou V, Trichopoulos D, Ordovas

JM. Genetic predisposition, non-genetic risk factors and coronary infarct. Arch Intern

Med (in press)

436. Perez-Martinez P, Yiannakouris N, Lopez-Miranda J, Arnett D, Tsai M, Galan E, Straka

R, Delgado-Lista J, Province M, Ruano J, Borecki I, Hixson J, Garcia-Bailo B, Perez-Jimenez

F, Ordovas, JM. Postprandial Triglyceride Metabolism is Modified by the Presence of

Genetic Variation at the Perilipin (PLIN) Locus in Two Caucasian Populations. Am. J. Clin

Nutr. 2008 Mar;87(3):744-52

437. Bureau A, Diallo MS, Ordovas JM, Cupples LA. Estimating Interaction Between Genetic

and Environmental Risk Factors: Efficiency of Sampling Designs Within a Cohort.

Epidemiology. 2008 Jan;19(1):83-93.

60

438. Lai CQ, Tucker KL, Parnell LD, Adiconis X, García-Bailo B, Griffith J, Meydani M,

Ordovás JM. PPARGC1A (PGC-1{alpha}) variation associated with DNA damage, diabetes

and cardiovascular diseases: the Boston Puerto Rican Health Study. Diabetes. 2007 Dec

27

439. Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, Mark J

Rieder, Gregory M Cooper, Charlotta Roos, Benjamin F Voight, Aki S Havulinna, Björn

Wahlstrand, Thomas Hedner, Dolores Corella, E Shyong Tai, Jose M Ordovas, Göran

Berglund, Erkki Vartiainen, Pekka Jousilahti, Bo Hedblad, Marja-Riitta Taskinen,

Christopher Newton-Cheh, Veikko Salomaa, Leena Peltonen, Leif Groop, David M

Altshuler & Marju Orho-Melander. Six new loci associated with blood low-density

lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Nature Genetics. Published online: 13 January 2008

440. Ordovas JM. Genetic links between diabetes mellitus and coronary atherosclerosis.

Curr Atheroscler Rep. 2007 Sep;9(3):204-10.

441. Ordovas J. Diet/genetic interactions and their effects on inflammatory markers. Nutr

Rev. 2007 Dec;65(12 Pt 2):S203-7.

442. Hyun YJ, Koh SJ, Chae JS, Kim JY, Kim OY, Lim HH, Jang Y, Park S, Ordovas JM, Lee JH.

Atherogenecity of LDL and Unfavorable Adipokine Profile in Metabolically Obese,

Normal-weight Woman. Obesity (Silver Spring). 2008 Jan 24;

443. Ordovas, Jose M. Gender, a Significant Factor in the Cross Talk Between Genes,

Environment, and Health. Gender Medicine. 2007; 4 (suppl. B):S111-S122.

444. Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema

JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB,

Ordovas JM, Schaefer EJ; for the PROSPER Study Group. Genetic variation at the PCSK9

locus moderately lowers low-density lipoprotein cholesterol levels, but does not

significantly lower vascular disease risk in an elderly population. Atherosclerosis. 2008

Feb 7; [Epub ahead of print]

445. Polisecki E, Muallem H, Maeda N, Peter I, Robertson M, McMahon AD, Ford I, Packard

C, Shepherd J, Jukema JW, Westendorp RG, de Craen AJ, Buckley BM, Ordovas JM,

Schaefer EJ; on behalf of the Prospective Study of Pravastatin in the Elderly at Risk

(PROSPER) Investigators. Genetic variation at the LDL receptor and HMG-CoA reductase

61

gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.

Atherosclerosis. 2008 Feb 6;

446. Pérez-Martínez P, López-Miranda J, Ordovás JM, Pérez-Jiménez F. [Nutrition in the

age of genomics: towards a personalized diet.] Med Clin (Barc). 2008 Feb 2;130(3):103-

108.

447. Ordovas JM. Genetic links between diabetes mellitus and coronary atherosclerosis.

Curr Atheroscler Rep. 2007 Sep;9(3):204-10.

448. Shen J, Arnett DK, Parnell LD, Peacock JM, Lai CQ, Hixson JE, Tsai MY, Province MA,

Straka RJ, Ordovas JM. Association of common C-reactive protein (CRP) gene

polymorphisms with baseline plasma CRP levels and fenofibrate response: The GOLDN

Study. Diabetes Care. 2008 Feb 19;

449. Liu L, Lai CQ, Nie L, Ordovas J, Band M, Moser L, Meydani M. The modulation of

endothelial cell gene expression by green tea polyphenol-EGCG. Mol Nutr Food Res.

2008 May 8.

450. Ordovas JM, Tai ES. Why study gene-environment interactions? Curr Opin Lipidol.

2008 Apr;19(2):158-67.

451. Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM,

Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS. The protective effect of

KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-

blockade. J Hum Hypertens. 2008 Apr 17. [Epub ahead of print]

452. Shen J, Arnett DK, Pérez-Martínez P, Parnell LD, Lai CQ, Peacock JM, Hixson JE, Tsai

MY, Straka RJ, Hopkins PN, Ordovás JM. The effect of IL6-174C/G polymorphism on

postprandial triglycerides metabolism in the GOLDN study. J Lipid Res. 2008 Apr 16.

453. Ackert-Bicknell CL, Demissie S, de Evsikova CM, Hsu YH, Demambro VE, Karasik D,

Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J,

Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. A PPARG by Dietary Fat

Interaction Influences Bone Mass in Mice and Humans. J Bone Miner Res. 2008

Sep;23(9):1398-408.

62

454. Trichopoulou A, Yiannakouris N, Bamia C, Benetou V, Trichopoulos D, Ordovas JM.

Genetic predisposition, nongenetic risk factors, and coronary infarct. Arch Intern Med.

2008 Apr 28;168(8):891-6.

455. Aron M. Troen AM, French EE, Roberts JF, Selhub J, Ordovas JM, Parnell LD, Lai CQ.

Lifespan modification by glucose and methionine in Drosophila melanogaster fed a

chemically defined diet. AGE. 29:29-39 (2007).

456. Tai ES, Ordovas JM. Clinical significance of apolipoprotein A5. Curr Opin Lipidol. 2008

Aug;19(4):349-354.

457. Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F, Ordovas JM. Influence of genetic

factors in the modulation of postprandial lipemia. Atheroscler Suppl. 2008 Jul 4. [Epub

ahead of print]

458. Koh SJ, Jang Y, Hyun YJ, Park JY, Song YD, Shin KK, Chae JS, Kim BK, Ordovas JM, Lee

JH. The interleukin-6 -572C-->G promoter polymorphism is associated with Type 2

diabetes risk in Koreans. Clin Endocrinol (Oxf). 2008 Jun 20. [Epub ahead of print]

459. Liu Y, Ordovas JM, Gao G, Province M, Straka RJ, Tsai MY, Lai CQ, Zhang K, Borecki I,

Hixson JE, Allison DB, Arnett DK. The SCARB1 gene is associated with lipid response to

dietary and pharmacological interventions. J Hum Genet. 2008;53(8):709-17. Epub 2008

Jun 10.

460. Pérez-Martínez P, López-Miranda J, Cruz-Teno C, Delgado-Lista J, Jiménez-Gómez Y,

Fernández JM, Gómez MJ, Marín C, Pérez-Jiménez F, Ordovás JM. Adiponectin gene

variants are associated with insulin sensitivity in response to dietary fat consumption in

caucasian men. J Nutr. 2008 Sep;138(9):1609-14.

461. Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM,

Peterson JW, Booth SL. Vitamin K, circulating cytokines, and bone mineral density in

older men and women. Am J Clin Nutr. 2008 Aug;88(2):356-63.

462. Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C,

Tewhey R, Rieder MJ, Hall J, Abecasis G, Tai ES, Welch C, Arnett DK, Lyssenko V,

Lindholm E, Saxena R, de Bakker PI, Burtt N, Voight BF, Hirschhorn JN, Tucker KL, Hedner

T, Tuomi T, Isomaa B, Eriksson KF, Taskinen MR, Wahlstrand B, Hughes TE, Parnell LD,

Lai CQ, Berglund G, Peltonen L, Vartiainen E, Jousilahti P, Havulinna AS, Salomaa V,

Nilsson P, Groop L, Altshuler D, Ordovas JM, Kathiresan S. A Common Missense Variant

63

in the Glucokinase Regulatory Protein Gene (GCKR) is Associated with Increased Plasma

Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes.

2008 Aug 4. [Epub ahead of print]

463. Ordovas JM, Shen J. Gene-environment interactions and susceptibility to metabolic

syndrome and other chronic diseases. J Periodontol. 2008 Aug;79(8 Suppl):1508-13.

464. Deram S, Nicolau CY, Perez-Martinez P, Guazzelli I, Halpern A, Wajchenberg BL,

Ordovas JM, Villares SM. Effects of perilipin (PLIN) gene variation on metabolic

syndrome risk and weight-loss in obese children and adolescents. J Clin Endocrinol

Metab. 2008 Dec;93(12):4933-40.

465. Smith CE, Tucker KL, Yiannakouris N, Garcia-Bailo B, Mattei J, Lai CQ, Parnell LD,

Ordovás JM. Perilipin polymorphism interacts with dietary carbohydrates to modulate

anthropometric traits in hispanics of Caribbean origin. J Nutr. 2008 Oct;138(10):1852-8.

466. Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, Glasser SP, Arnett DK.

Smoking, inflammatory patterns and postprandial hypertriglyceridemia. Atherosclerosis.

2008 Aug 13.

467. Tai ES, Sim XL, Ong TH, Wong TY, Saw SM, Aung T, Kathiresan S, Orho-Melander M,

Ordovas JM, Tan JT, Seielstad M. Polymorphisms at newly identified lipid associated loci

are associated with blood lipids and cardiovascular disease an Asian Malay population. J

Lipid Res. 2008 Nov 5. [Epub ahead of print]

468. Kaput J, Astley S, Renkema M, Ordovas J, van Ommen B. Harnessing utrigenomics:

Development of web-based communication, databases, resources, and tools. Genes

Nutr. 2006 Mar;1(1):5-11.

469. Williams CM, Ordovas JM, Lairon D, Hesketh J, Lietz G, Gibney M, van Ommen B. The

challenges for molecular nutrition research 1: linking genotype to healthy nutrition.

Genes Nutr. 2008 Jul;3(2):41-9.

470. Junyent M, Tucker KL, Smith CE, Garcia-Rios A, Mattei J, Lai CQ, Parnell LD, Ordovas

JM. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations

depend on smoking habit in the Boston Puerto Rican health study. J Lipid Res. 2008 Nov

12. [Epub ahead of print]

64

471. Liu Y, Ordovas JM, Gao G, Province M, Straka RJ, Tsai MY, Lai CQ, Zhang K, Borecki I,

Hixson JE, Allison DB, Arnett DK. Pharmacogenetic association of the APOA1/C3/A4/A5

gene cluster and lipid responses to fenofibrate: the Genetics of Lipid-Lowering Drugs

and Diet Network study. Pharmacogenet Genomics. 2008 Dec 2.

472. Sanchez-Muniz FJ, Maki KC, Schaefer EJ, Ordovas JM. Serum lipid and antioxidant

responses in hypercholesterolemic men and women receiving plant sterol esters vary by

apolipoprotein E genotype. J Nutr. 2009 Jan;139(1):13-9.

473. Perez-Martinez P, Corella D, Shen J, Arnett DK, Yiannakouris N, Tai ES, Orho-Melander

M, Tucker KL, Tsai M, Straka RJ, Province M, Kai CS, Perez-Jimenez F, Lai CQ, Lopez-

Miranda J, Guillen M, Parnell LD, Borecki I, Kathiresan S, Ordovas JM. Association

between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene

polymorphisms and triacylglycerol concentrations in fasting postprandial, and

fenofibrate-treated states. Am J Clin Nutr. 2008 Dec 3. [Epub ahead of print]

474. Kathiresan S, Willer CJ, Peloso G, Demissie S, Musunuru K, Schadt E, Kaplan L, Bennett

D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C,

Burtt N, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham

HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet

P, Sanna S, Uda M, Yang Q, Lunetta K, Dupuis J, deBakker PI, O’Donnell CJ, Chambers JC,

Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, TuomilehtoJ,

Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen

L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA.

Common DNA Sequence Variants at Thirty Genetic Loci Contribute to Polygenic

Dyslipidemia. Nature Genetics 2009 Jan;41(1):56-65.

475. Lai CQ, Tucker KL, Choudhry S, Parnell LD, Mattei J, García-Bailo B, Beckman K,

Burchard EG, Ordovás JM. Population admixture associated with disease prevalence in

the Boston Puerto Rican health study. Hum Genet. 2008 Dec 24.

476. Shen J, Ordovas JM. Impact of Genetic and Environmental Factors on hsCRP

Concentrations and Response to Therapeutic Agents. Clin Chem. 2008 Dec 12.

477. Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, Straka RJ,

Province MA, An P, Borecki IB, Tucker KL, Ordovás JM. WDTC1, the Ortholog of

Drosophila Adipose Gene, Associates With Human Obesity, Modulated by MUFA Intake.

Obesity (Silver Spring). 2009 Mar;17(3):593-600. Epub 2008 Dec 18.

65

478. Warodomwichit D, Shen J, Arnett DK, Tsai MY, Kabagambe EK, Peacock JM, Hixson JE,

Straka RJ, Province MA, An P, Lai CQ, Parnell LD, Borecki IB, Ordovas JM. ADIPOQ

Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study.

Obesity (Silver Spring). 2009 Mar;17(3):510-7. Epub 2008 Dec 18.

479. Bleys J, Navas-Acien A, Laclaustra M, Pastor-Barriuso R, Menke A, Ordovas J, Stranges

S, Guallar E. Serum Selenium and Peripheral Arterial Disease: Results From the National

Health and Nutrition Examination Survey, 2003-2004. Am J Epidemiol. 2009 Apr

15;169(8):996-1003

480. Hyun YJ, Jang Y, Chae JS, Kim JY, Paik JK, Kim SY, Yang JY, Ordovas JM, Ko YG, Lee JH.

Association of apolipoprotein A5 concentration with serum insulin and triglyceride

levels and coronary artery disease in Korean men. Atherosclerosis. 2009 Aug;205(2):568-

73

481. Jang Y, Paik JK, Hyun YJ, Chae JS, Kim JY, Choi JR, Lee SH, Shin DJ, Ordovas JM, Lee JH.

The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with

plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary

artery disease. Clin Chim Acta. 2009 Apr;402(1-2):83-7.

482. Ordovas JM. Genotype-phenotype associations: modulation by diet and obesity.

Obesity (Silver Spring). 2008 Dec;16 Suppl 3:S40-6.

483. Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, Singleton A,

Bandinelli S, Cherubini A, Arnett D, Tsai MY, Ferrucci L. Genome-wide association study

of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet. 2009

Jan;5(1):e1000338. Epub 2009 Jan 16.

484. Warodomwichit D, Arnett DK, Kabagambe EK, Tsai MY, Hixson JE, Straka RJ, Province

M, An P, Lai CQ, Borecki I, Ordovas JM. Polyunsaturated fatty acids modulate the effect

of TCF7L2 gene variants on postprandial lipemia. J Nutr. 2009 Mar;139(3):439-46. Epub

2009 Jan 13.

485. Smith CE, Arnett DK, Tsai MY, Lai CQ, Parnell LD, Shen J, Laclaustra M,Junyent M,

Ordovás JM. Physical inactivity interacts with an endothelial lipase polymorphism to

modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis. 2009

Oct;206(2):500-4.

66

486. Junyent M, Lee Y, Smith CE, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ,Province M,

An P, Lai CQ, Parnell LD, Shen J, Borecki I, Ordovas JM. The effect of a novel intergenic

polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB

polymorphism in the cholesterol ester transfer protein gene. Nutr Metab Cardiovasc Dis.

2009 Apr 11. [Epub ahead of print]

487. Crosier MD, Booth SL, Peter I, Dawson-Hughes B, Price PA, O'Donnell CJ,Hoffmann U,

Williamson MK, Ordovas JM. Matrix Gla protein polymorphisms are associated with

coronary artery calcification in men. J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):59-65.

488. Ordovas JM. Genetic influences on blood lipids and cardiovascular disease risk: tools

for primary prevention. Am J Clin Nutr. 2009 May;89(5):1509S-1517S.

489. Junyent M, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Lai CQ,

Parnell LD, Shen J, Lee YC, Borecki I, Ordovás JM. Genetic variants at the PDZ-interacting

domain of the scavenger receptor class B type I interact with diet to influence the risk of

metabolic syndrome in obese men and women. J Nutr. 2009 May;139(5):842-8. Epub

2009 Mar 25.

490. Franco OH, Karnik K, Osborne G, Ordovas JM, Catt M, van der Ouderaa F. Changing

course in ageing research: The Healthy Ageing Phenotype. Maturitas, 2009 May

20;63(1):13-9.

491. Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM,Price

PA, Williamson MK, Booth SL. Vitamin K supplementation and progression of coronary

artery calcium in older men and women. Am J Clin Nutr. 2009 Jun;89(6):1799-807.

492. Smith CE, Tucker KL, Scott TM, Van Rompay M, Mattei J, Lai CQ, Parnell LD,Junyent M,

Lee YC, Garcia-Bailo B, Ordovás JM. Apolipoprotein C3 polymorphisms,cognitive

function and diabetes in Caribbean origin Hispanics. PLoS One. 2009;4(5):e5465. Epub

2009 May 8.

493. Crosier MD, Peter I, Booth SL, Bennett G, Dawson-Hughes B, Ordovas JM. Association

of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase

genes with biochemical measures of vitamin K status. J Nutr Sci Vitaminol (Tokyo). 2009

Apr;55(2):112-9.

494. Tsai MY, Ordovas JM. APOC3 mutation, serum triglyceride concentrations, and

coronary heart disease. Clin Chem. 2009 Jul;55(7):1274-6.

67

495. Noel SE, Newby PK, Ordovas JM, Tucker KL. A traditional rice and beans pattern is

associated with metabolic syndrome in Puerto Rican older adults. J Nutr. 2009

Jul;139(7):1360-7.

496. Gómez-Santos C, Gómez-Abellán P, Madrid JA, Hernández-Morante JJ, Lujan

JA,Ordovas JM, Garaulet M. Circadian rhythm of clock genes in human adipose explants.

Obesity (Silver Spring). 2009 Aug;17(8):1481-5.

497. Junyent M, Tucker KL, Shen J, Lee YC, Smith CE, Mattei J, Lai CQ, Parnell LD,Ordovas

JM. A composite scoring of genotypes discriminates coronary heart disease risk beyond

conventional risk factors in the Boston Puerto Rican Health Study. Nutr Metab

Cardiovasc Dis. 2009 Jun 4.

498. Delgado-Lista J, Perez-Jimenez F, Ruano J, Perez-Martinez P, Fuentes F,Criado-Garcia J,

Parnell LD, Garcia-Rios A, Ordovas JM, Lopez-Miranda J. Effects of variations in the

APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism

in healthy young men. J Lipid Res. 2009 Jul 10.

499. Junyent M, Parnell LD, Lai CQ, Lee YC, Smith CE, Arnett DK, Tsai MY, Kabagambe EK,

Straka RJ, Province M, An P, Borecki I, Ordovás JM. Novel variants at KCTD10, MVK, and

MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol

concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. Am J

Clin Nutr. 2009 Sep;90(3):686-94.

500. Smith CE, Tucker KL, Lai CQ, Parnell LD, Lee YC, Ordovás JM. Apolipoprotein A5 and

Lipoprotein Lipase Interact to Modulate Anthropometric Measures in Hispanics of

Caribbean Origin. Obesity (Silver Spring). 2009 Jul 23. [Epub ahead of print]

501. Mattei J, Parnell LD, Lai CQ, Garcia-Bailo B, Adiconis X, Shen J, Arnett D,Demissie S,

Tucker KL, Ordovas JM. Disparities in allele frequencies and population differentiation

for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and

non-Hispanic whites. BMC Genet. 2009 Aug 14;10:45.

502. Junyent M, Tucker KL, Smith CE, Lane JM, Mattei J, Lai CQ, Parnell LD,Ordovas JM. The

effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on

ABCA1 genetic variants in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc

Dis. 2009 Aug 17.

68

503. Belisle SE, Leka LS, Delgado-Lista J, Jacques PF, Ordovas JM, Meydani SN.

Polymorphisms at cytokine genes may determine the effect of vitamin E on cytokine

production in the elderly. J Nutr. 2009 Oct;139(10):1855-60. Epub 2009 Aug 26.

504. Ordovás JM. [Integrating environment and disease into "omic" analysis]. Rev Esp

Cardiol. 2009 Jun;62 Suppl 2:17-22.

505. Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E. Serum selenium

concentrations and diabetes in U.S. adults: National Health and Nutrition Examination

Survey (NHANES) 2003-2004. Environ Health Perspect. 2009 Sep;117(9):1409-13.

506. Melistas L, Mantzoros C, Kontogianni M, Antonopoulou S, Ordovas J, Yiannakouris N.

Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with

insulin resistance in non-diabetic Greek women. Eur J Endocrinol. 2009 Sep 15.

507. Perez-Martinez P, Ordovas JM, Garcia-Rios A, Delgado-Lista J, Delgado-Casado N, Cruz-

Teno C, Camargo A, Yubero-Serrano EM, Rodriguez F, Perez-Jimenez F, Lopez-Miranda J.

Consumption of diets with different type of fat influences triacylglycerols-rich

lipoproteins particle number and size during the postprandial state. Nutr Metab

Cardiovasc Dis. 2009 Oct 8. [Epub ahead of print]

508. Junyent M, Parnell LD, Lai CQ, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ,Province

M, An P, Smith CE, Lee YC, Borecki I, Ordovás JM. ADAM17_i33708A>G polymorphism

interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the

Genetics of Lipid Lowering Drugs and Diet Network study. Nutr Metab Cardiovasc Dis.

2009 Oct 8. [Epub ahead of print]

509. Kabagambe EK, Glasser SP, Ordovas JM, Warodomwichit D, Tsai MY, Hopkins

PN,Borecki IB, Wojczynski M, Arnett DK. TCF7L2 polymorphisms and inflammatory

markers before and after treatment with fenofibrate. Diabetol Metab Syndr. 2009 Oct

12;1(1):16.

510. Mattei J, Demissie S, Tucker KL, Ordovas JM. Apolipoprotein A5 Polymorphisms

Interact with Total Dietary Fat Intake in Association with Markers of Metabolic

Syndrome in Puerto Rican Older Adults. J Nutr. 2009 Dec;139(12):2301-8.

511. Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM. CLOCK

genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty

acids. Am J Clin Nutr. 2009 Dec;90(6):1466-75.

69

512. Richardson K, Ordovas JM. Functional genomic and epidemiological studies reveal

novel genes regulating cholesterol metabolism. Genome Med. 2009 Oct 27;1(10):96.

[Epub ahead of print]

513. Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples

LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D,Planells R, Roche

HM. Complement component 3 polymorphisms interact with polyunsaturated fatty

acids to modulate risk of metabolic syndrome. Am J Clin Nutr. 2009 Dec;90(6):1665-73.

514. Gómez-Abellán P, Gómez-Santos C, Madrid JA, Milagro FI, Campion J, Martínez JA,

Ordovás JM, Garaulet M. Circadian expression of adiponectin and its receptors in human

adipose tissue. Endocrinology. 2010 Jan;151(1):115-22.

515. Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM.

Genetic variants in human CLOCK associate with total energy intake and cytokine sleep

factors in overweight subjects (GOLDN population). Eur J Hum Genet. 2009 Nov 4.

516. Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai CQ,Parnell LD,

Coltell O, Lee YC, Ordovas JM. APOA2, dietary fat, and body mass index: replication of a

gene-diet interaction in 3 independent populations. Arch Intern Med. 2009 Nov

9;169(20):1897-906.

517. Phillips CM, Goumidi L, Bertrais S, Field MR, Ordovas JM, Cupples LA, Defoort C,

Lovegrove JA, Drevon CA, Blaak EE, Gibney MJ, Kiec-Wilk B, Karlstrom B,Lopez-Miranda

J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. Leptin Receptor

Polymorphisms Interact with Polyunsaturated Fatty Acids to Augment Risk of Insulin

Resistance and Metabolic Syndrome in Adults. J Nutr. 2009 Dec 23.


concentrations and hypertension in the US Population. Circ Cardiovasc Qual Outcomes.

2009 Jul;2(4):369-76.

519. Corella D, Ordovas JM. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc

Genet. 2009 Dec;2(6):637-51.

520. Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu

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Belisle SE, Rodriguez-Cantalejo F, Meydani SN, Ordovas JM, Perez-Jimenez F, Lopez-

Miranda J. Interleukin 1B Variant -1473G/C (rs1143623) Influences Triglyceride and

Interleukin 6 Metabolism. J Clin Endocrinol Metab. 2011 May;96(5):E816-20. Epub 2011

Feb 9. PubMed PMID: 21307135; PubMed Central PMCID: PMC3085209.

589. Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The Folate Hydrolase

1561C>T Polymorphism Is Associated With Depressive Symptoms in Puerto Rican Adults.

Psychosom Med. 2011 May 19. [Epub ahead of print] PubMed PMID: 21597034.

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590. Aslibekyan S, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Baylin A. Development

of a Cardiovascular Risk Score for Use in Low- and Middle-Income Countries. J Nutr.

2011 May 11. [Epub ahead of print] PubMed PMID: 21562240.

591. Richardson K, Louie-Gao Q, Arnett DK, Parnell LD, Lai CQ, Davalos A, Fox CS, Demissie

S, Cupples LA, Fernandez-Hernando C, Ordovas JM. The PLIN4 Variant rs8887 Modulates

Obesity Related Phenotypes in Humans through Creation of a Novel miR-522 Seed Site.

PLoS One. 2011 Apr 20;6(4):e17944. PubMed PMID: 21533135; PubMed Central PMCID:

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adipose tissue metabolism. J Cell Physiol. 2011 Aug;226(8):2075-80. doi:

10.1002/jcp.22531. PubMed PMID: 21520059.

593. Gesteiro E, Bastida S, Vázquez-Velasco M, Corella D, Guillén M, Ordovas JM, Sánchez-

Muniz FJ. Effects of APOA5 S19W polymorphism on growth, insulin sensitivity and

lipoproteins in normoweight neonates. Eur J Pediatr. 2011 Apr 20. [Epub ahead of print]


594. Zachariah JP, Pencina MJ, Lyass A, Kaur G, D'Agostino RB, Ordovas JM, Vasan RS.

Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking

in the community. J Hypertens. 2011 May;29(5):863-8. PubMed PMID: 21430561.

595. Garaulet M, Sánchez-Moreno C, Smith CE, Lee YC, Nicolás F, Ordovás JM. Ghrelin,

sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and

weight loss. PLoS One. 2011 Feb 28;6(2):e17435. PubMed PMID: 21386998; PubMed

Central PMCID: PMC3046145.

596. Smith CE, Ordovás JM, Sánchez-Moreno C, Lee YC, Garaulet M. Apolipoprotein A-II

polymorphism: relationships to behavioural and hormonal mediators of obesity. Int J

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597. Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D,

Lai CQ. Interactions between genetic variants of folate metabolism genes and lifestyle

affect plasma homocysteine concentrations in the Boston Puerto Rican population.

Public Health Nutr. 2011 Feb 22:1-8. [Epub ahead of print] PubMed PMID: 21338559.

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598. Feitosa MF, An P, Ordovas JM, Ketkar S, Hopkins PN, Straka RJ, Arnett DK, Borecki IB.

Association of gene variants with lipid levels in response to fenofibrate is influenced by

metabolic syndrome status. Atherosclerosis. 2011 Apr;215(2):435-9. Epub 2011 Jan 21.


599. Ordovás JM, Robertson R, Cléirigh EN. Gene-gene and gene-environment interactions

defining lipid-related traits. Curr Opin Lipidol. 2011 Apr;22(2):129-36. PubMed PMID:

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600. Sánchez-Moreno C, Ordovás JM, Smith CE, Baraza JC, Lee YC, Garaulet M. APOA5 gene

variation interacts with dietary fat intake to modulate obesity and circulating

triglycerides in a Mediterranean population. J Nutr. 2011 Mar;141(3):380-5. Epub 2011

Jan 5. PubMed PMID: 21209257; PubMed Central PMCID: PMC3040902.

601. Tsai AK, Steffen BT, Ordovas JM, Straka R, Zhou X, Hanson NQ, Arnett D, Tsai MY.

Short-term fenofibrate treatment reduces elevated plasma Lp-PLA(2) mass and sVCAM-

1 levels in a subcohort of hypertriglyceridemic GOLDN participants. Transl Res. 2011

Aug;158(2):99-105. Epub 2011 Feb 26. PubMed PMID: 21757154; PubMed Central

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602. Hamilton CM, Strader LC, Pratt JG, Maiese D, Hendershot T, Kwok RK, Hammond JA,

Huggins W, Jackman D, Pan H, Nettles DS, Beaty TH, Farrer LA, Kraft P, Marazita ML,

Ordovas JM, Pato CN, Spitz MR, Wagener D, Williams M, Junkins HA, Harlan WR, Ramos

EM, Haines J. The PhenX Toolkit: Get the Most From Your Measures. Am J Epidemiol.

2011 Aug 1;174(3):253-60. Epub 2011 Jul 11. PubMed PMID: 21749974; PubMed





EM, Haines J. Hamilton et al. Respond to "Consolidating Data Harmonization". Am J

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604. Misra D, Booth SL, Crosier MD, Ordovas JM, Felson DT, Neogi T. Matrix Gla Protein

Polymorphism, But Not Concentrations, Is Associated with Radiographic Hand

Osteoarthritis. J Rheumatol. 2011 Jul 1. [Epub ahead of print] PubMed PMID: 21724703.

605. Corbalán-Tutau MD, Madrid JA, Ordovás JM, Smith CE, Nicolás F, Garaulet M.

Differences in daily rhythms of wrist temperature between obese and normal-weight

82

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May;28(5):425-33. PubMed PMID: 21721858.

606. Marti A, Ordovas J. Epigenetics lights up the obesity field. Obes Facts. 2011;4(3):187-

90. Epub 2011 Jun 17. PubMed PMID: 21701233.

607. Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Mc Monagle J, Gulseth HL, Ordovas

JM, Shaw DI, Karlström B, Kiec-Wilk B, Blaak EE, Helal O, Malczewska-Malec M, Defoort

C, Risérus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J.

Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to

Influence Insulin Resistance and Inflammation in Metabolic Syndrome. PLoS One.

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608. Mata N, Alonso R, Badimón L, Padró T, Fuentes F, Muñiz O, Perez-Jiménez F, López-

Miranda J, Díaz JL, Vidal JI, Barba A, Piedecausa M, Sanchez JF, Irigoyen L, Guallar E,

Ordovas JM, Mata P. Clinical characteristics and evaluation of LDL-cholesterol treatment

of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART).

Lipids Health Dis. 2011 Jun 10;10:94. PubMed PMID: 21663647; PubMed Central PMCID:

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609. Shea MK, O'Donnell CJ, Vermeer C, Magdeleyns EJ, Crosier MD, Gundberg CM,

Ordovas JM, Kritchevsky SB, Booth SL. Circulating uncarboxylated matrix gla protein is

associated with vitamin k nutritional status, but not coronary artery calcium, in older

adults. J Nutr. 2011 Aug;141(8):1529-34. Epub 2011 May 31. PubMed PMID: 21628633;


610. Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The folate hydrolase

1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.

Psychosom Med. 2011 Jun;73(5):385-92. Epub 2011 May 19. PubMed PMID: 21597034;


611. Aslibekyan S, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Baylin A. Development

of a cardiovascular risk score for use in low- and middle-income countries. J Nutr. 2011

Jul;141(7):1375-80. Epub 2011 May 11. PubMed PMID: 21562240; PubMed Central

PMCID: PMC3113291.

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612. Ordovás JM, Robertson R, Cléirigh EN. Gene-gene and gene-environment interactions

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613. Aslibekyan S, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY,

Hopkins PN, Shen J, Lai CQ, Ordovas JM, Arnett DK. A genome-wide association study of

inflammatory biomarker changes in response to fenofibrate treatment in the Genetics

of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics. 2012 Jan 5. [Epub


614. Cusano NE, Kiel DP, Demissie S, Karasik D, Adrienne Cupples L, Corella D, Gao Q,

Richardson K, Yiannakouris N, Ordovas JM. A Polymorphism in a Gene Encoding Perilipin

4 Is Associated with Height but not with Bone Measures in Individuals from the

Framingham Osteoporosis Study. Calcif Tissue Int. 2011 Dec 31. [Epub ahead of print]


615. Frazier-Wood AC, Glasser S, Garvey WT, Kabagambe EK, Borecki IB, Tiwari HK, Tsai MY,

Hopkins PN, Ordovas JM, Arnett DK. A clustering analysis of lipoprotein diameters in

the metabolic syndrome. Lipids Health Dis. 2011 Dec 19;10:237. PubMed PMID:

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616. Feng R, Wu Y, Jang GH, Ordovas JM, Arnett D. A powerful test of parent-of-origin

effects for quantitative traits using haplotypes. PLoS One. 2011;6(12):e28909. Epub

2011 Dec 13. PubMed PMID: 22174922; PubMed Central PMCID: PMC3236760.

617. Garaulet M, Smith CE, Hernández-González T, Lee YC, Ordovás JM. PPARγ Pro12Ala

interacts with fat intake for obesity and weight loss in a behavioural treatment based on

the Mediterranean diet. Mol Nutr Food Res. 2011 Dec;55(12):1771-9. doi:

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618. Gómez-Abellán P, Madrid JA, Ordovás JM, Garaulet M. Chronobiological aspects of

obesity and metabolic syndrome. Endocrinol Nutr. 2012 Jan;59(1):50-61. Epub 2011 Nov

18. English, Spanish. PubMed PMID: 22100640.

619. Gómez-Abellán P, Madrid JA, Luján JA, Frutos MD, González R, Martínez-Augustín O,

de Medina FS, Ordovás JM, Garaulet M. Sexual dimorphism in clock genes expression in

human adipose tissue. Obes Surg. 2012 Jan;22(1):105-12. PubMed PMID: 22081238.

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620. Shen J, Arnett DK, Parnell LD, Lai CQ, Straka RJ, Hopkins PN, An P, Feitosa MF, Ordovás

JM. The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. J Cardiovasc

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621. Corella D, Arnett DK, Tucker KL, Kabagambe EK, Tsai M, Parnell LD, Lai CQ, Lee YC,

Warodomwichit D, Hopkins PN, Ordovas JM. A high intake of saturated fatty acids

strengthens the association between the fat mass and obesity-associated gene and BMI.

J Nutr. 2011 Dec;141(12):2219-25. Epub 2011 Nov 2. PubMed PMID: 22049296;


622. Wojczynski MK, Glasser SP, Oberman A, Kabagambe EK, Hopkins PN, Tsai MY, Straka

RJ, Ordovas JM, Arnett DK. High-fat meal effect on LDL, HDL, and VLDL particle size and

number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an

interventional study. Lipids Health Dis. 2011 Oct 18;10:181. PubMed PMID: 22008512;


623. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S,

Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ,

Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden

JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood

LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A,

Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF,

Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E,

Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y,

Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB,

Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP,

Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf

U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM,

Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H,

Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-

wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-

analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT)

Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD)

Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses

of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR,

Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy

MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk

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RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM,

Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M,

Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner

JS. Genome-wide association study identifies loci influencing concentrations of liver

enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.


624. Richardson K, Lai CQ, Parnell LD, Lee YC, Ordovas JM. A genome-wide survey for SNPs

altering microRNA seed sites identifies functional candidates in GWAS. BMC Genomics.

2011 Oct 13;12:504. PubMed PMID: 21995669; PubMed Central PMCID: PMC3207998.

625. Wood AC, Kabagambe EK, Borecki IB, Tiwari HK, Ordovas JM, Arnett DK. Dietary

Carbohydrate Modifies the Inverse Association Between Saturated Fat Intake and

Cholesterol on Very Low-Density Lipoproteins. Lipid Insights. 2011 Aug 23;2011(4):7-15.


626. Peter I, Huggins GS, Ordovas JM, Haan M, Seddon JM. Evaluation of new and

established age-related macular degeneration susceptibility genes in the Women's

Health Initiative Sight Exam (WHI-SE) Study. Am J Ophthalmol. 2011 Dec;152(6):1005-

1013.e1. Epub 2011 Sep 9. PubMed PMID: 21906714.

627. Hernandez-Morante JJ, Gomez-Santos C, Margareto J, Formiguera X, Martínez CM,

González R, Martínez-Augustín O, Madrid JA, Ordovas JM, Garaulet M. Influence of

menopause on adipose tissue clock gene genotype and its relationship with metabolic

syndrome in morbidly obese women. Age (Dordr). 2011 Sep 7. [Epub ahead of print]


628. Wood AC, Glasser S, Garvey WT, Kabagambe EK, Borecki IB, Tiwari HK, Tsai MY,

Hopkins PN, Ordovas JM, Arnett DK. Lipoprotein lipase S447X variant associated with

VLDL, LDL and HDL diameter clustering in the MetS. Lipids Health Dis. 2011 Aug

19;10:143. PubMed PMID: 21854610; PubMed Central PMCID: PMC3180704.

629. Kanoni S, Nettleton JA, Hivert MF, Ye Z, van Rooij FJ, Shungin D, Sonestedt E, Ngwa JS,

Wojczynski MK, Lemaitre RN, Gustafsson S, Anderson JS, Tanaka T, Hindy G, Saylor G,

Renstrom F, Bennett AJ, van Duijn CM, Florez JC, Fox CS, Hofman A, Hoogeveen RC,

Houston DK, Hu FB, Jacques PF, Johansson I, Lind L, Liu Y, McKeown N, Ordovas J,

Pankow JS, Sijbrands EJ, Syvänen AC, Uitterlinden AG, Yannakoulia M, Zillikens MC;

MAGIC Investigators, Wareham NJ, Prokopenko I, Bandinelli S, Forouhi NG, Cupples LA,

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Loos RJ, Hallmans G, Dupuis J, Langenberg C, Ferrucci L, Kritchevsky SB, McCarthy MI,

Ingelsson E, Borecki IB, Witteman JC, Orho-Melander M, Siscovick DS, Meigs JB, Franks

PW, Dedoussis GV. Total zinc intake may modify the glucose-raising effect of a zinc

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630. Tsai AK, Steffen BT, Ordovas JM, Straka R, Zhou X, Hanson NQ, Arnett D, Tsai MY.

Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1

levels in a subcohort of hypertriglyceridemic GOLDN participants. Transl Res. 2011

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EM, Haines J. The PhenX Toolkit: get the most from your measures. Am J Epidemiol.

2011 Aug 1;174(3):253-60. Epub 2011 Jul 11. PubMed PMID: 21749974; PubMed





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633. Misra D, Booth SL, Crosier MD, Ordovas JM, Felson DT, Neogi T. Matrix Gla protein

polymorphism, but not concentrations, is associated with radiographic hand

osteoarthritis. J Rheumatol. 2011 Sep;38(9):1960-5. Epub 2011 Jul 1. PubMed PMID:


634. Corbalán-Tutau MD, Madrid JA, Ordovás JM, Smith CE, Nicolás F, Garaulet M.

Differences in daily rhythms of wrist temperature between obese and normal-weight

women: associations with metabolic syndrome features. Chronobiol Int. 2011

May;28(5):425-33. PubMed PMID: 21721858.

635. Marti A, Ordovas J. Epigenetics lights up the obesity field. Obes Facts. 2011;4(3):187-

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636. Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Mc Monagle J, Gulseth HL, Ordovas

JM, Shaw DI, Karlström B, Kiec-Wilk B, Blaak EE, Helal O, Malczewska-Malec M, Defoort

C, Risérus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J.

Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to

influence insulin resistance and inflammation in metabolic syndrome. PLoS One.

2011;6(6):e20555. Epub 2011 Jun 6. PubMed PMID: 21674002; PubMed Central PMCID:

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637. Lee YC, Lai CQ, Ordovas JM, Parnell LD. A Database of Gene-Environment Interactions

Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes. J Data

Mining Genomics Proteomics. 2011 Jan 1;2(1). pii: 106. PubMed PMID: 22328972;


638. Garaulet M, Esteban Tardido A, Lee YC, Smith CE, Parnell LD, Ordovás JM. SIRT1 and

CLOCK 3111T>C combined genotype is associated with evening preference and weight

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639. Aslibekyan S, Jensen MK, Campos H, Linkletter CD, Loucks EB, Ordovas JM, Deka R,

Rimm EB, Baylin A. Genetic variation in fatty acid elongases is not associated with

intermediate cardiovascular phenotypes or myocardial infarction. Eur J Clin Nutr. 2012

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640. Ordovas-Montanes JM, Ordovas JM. Cholesterol, Inflammasomes, and Atherogenesis.

Curr Cardiovasc Risk Rep. 2012 Feb 1;6(1):45-52. PubMed PMID: 22368729; PubMed


641. Van Rompay MI, McKeown NM, Castaneda-Sceppa C, Falcon LM, Ordovas JM, Tucker

KL. Acculturation and Sociocultural Influences on Dietary Intake and Health Status

among Puerto Rican Adults in Massachusetts. J Acad Nutr Diet. 2012 Jan;112(1):64-74.


642. Gómez Abellán P, Gómez Santos C, Madrid JA, Milagro FI, Campion J, Martínez JA,

Luján JA, Ordovás JM, Garaulet M. Site-specific circadian expression of leptin and its

receptor in human adipose tissue. Nutr Hosp. 2011 Dec;26(6):1394-401. PubMed PMID:

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643. Frazier-Wood AC, Kabagambe EK, Borecki IB, Tiwari HK, Ordovas JM, Arnett DK.

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644. Moorthy D, Peter I, Scott TM, Parnell LD, Lai CQ, Crott JW, Ordovás JM, Selhub J,

Griffith J, Rosenberg IH, Tucker KL, Troen AM. Status of vitamins B-12 and B-6 but not of

folate, homocysteine, and the methylenetetrahydrofolate reductase C677T

polymorphism are associated with impaired cognition and depression in adults. J Nutr.

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645. van Bochove K, van Schalkwijk DB, Parnell LD, Lai CQ, Ordovás JM, de Graaf AA, van

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subgroups with positive lipid response to fenofibrate therapy. PLoS One.

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646. Shen LR, Xiao F, Yuan P, Chen Y, Gao QK, Parnell LD, Meydani M, Ordovas JM,Li D,

Lai CQ. Curcumin-supplemented diets increase superoxide dismutase activity and

mean lifespan in Drosophila. Age (Dordr). 2012 Jun 1. [Epub ahead of print]PubMed

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647. Bouchard C, Ordovas JM. Fundamentals of nutrigenetics and nutrigenomics. Prog

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648. Bouchard C, Ordovas J. Preface. Advances in nutrigenetics and nutrigenomics.Prog

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649. Casasnovas JA, Alcaide V, Civeira F, Guallar E, Ibañez B, Borreguero JJ,Laclaustra M,

León M, Peñalvo JL, Ordovás JM, Pocovi M, Sanz G, Fuster V. Aragon workers' health

study - design and cohort description. BMC Cardiovasc Disord. 2012 Jun 19;12:45.


650. Lluis-Ganella C, Subirana I, Lucas G, Tomás M, Muñoz D, Sentí M, Salas E, Sala J,

Ramos R, Ordovas JM, Marrugat J, Elosua R. Assessment of the value of a genetic risk

score in improving the estimation of coronary risk. Atherosclerosis. 2012


651. Frazier-Wood AC, Ordovas JM, Straka RJ, Hixson JE, Borecki IB, Tiwari HK,Arnett DK.

The PPAR alpha gene is associated with triglyceride, low-density cholesterol and

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652. Aslibekyan S, Jensen MK, Campos H, Linkletter CD, Loucks EB, Ordovas JM, Deka R,

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653. Milagro FI, Gómez-Abellán P, Campión J, Martínez JA, Ordovás JM, Garaulet M.

CLOCK, PER2 and BMAL1 DNA Methylation: Association with Obesity and Metabolic

Syndrome Characteristics and Monounsaturated Fat Intake. Chronobiol Int. 2012

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654. Frazier-Wood AC, Aslibekyan S, Borecki IB, Hopkins PN, Lai CQ, Ordovas JM,Straka

RJ, Tiwari HK, Arnett DK. Genome-wide association study indicates variants

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655. Yiannakouris N, Katsoulis M, Dilis V, Parnell LD, Trichopoulos D, Ordovas

JM,Trichopoulou A. Genetic predisposition to coronary heart disease and stroke

using an additive genetic risk score: a population-based study in Greece.

Atherosclerosis. 2012 May;222(1):175-9. Epub 2012 Feb 28. PubMed PMID:

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656. Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons

GH,Harrison DG, Liang M, Nathanielsz PW, O'Connor DT, Ordovas J, Peng W, Soares

MB,Szyf M, Tolunay HE, Wood KC, Zhao K, Galis ZS. Report of the National

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657. Corella D, Ordovás JM. Interactions between dietary n-3 fatty acids and genetic

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658. Zeisel SH, Waterland RA, Ordovás JM, Muoio DM, Jia W, Fodor A. Highlights of the

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659. Smith CE, Ordovás JM. Update on perilipin polymorphisms and obesity. Nutr Rev.

2012 Oct;70(10):611-21. doi: 10.1111/j.1753-4887.2012.00515.x. PubMed PMID:

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703. Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski

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704. Corella D, Carrasco P, Sorlí JV, Estruch R, Rico-Sanz J, Martínez-González

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708. The Coffee and Caffeine Genetics Consortium, Cornelis MC, Byrne EM, Esko T,

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725. Zanon-Moreno V, Zanon-Moreno L, Ortega-Azorin C, Asensio-Marquez EM,

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759. Ledesma M, Hurtado-Roca Y, Leon M, Giraldo P, Pocovi M, Civeira F, Guallar

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765. Daimiel-Ruiz L, Klett-Mingo M, Konstantinidou V, Micó V, Aranda JF, García B,

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766. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S,

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767. Moreno Franco B, León Latre M, Andrés Esteban EM, Ordovás JM,

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768. Dashti HS, Shea MK, Smith CE, Tanaka T, Hruby A, Richardson K, Wang TJ,

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769. Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. Development of an OP9

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770. Laclaustra M, Casasnovas JA, Fernández-Ortiz A, Fuster V, León-Latre M,

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771. Johnston JD, Ordovás JM, Scheer FA, Turek FW. Circadian Rhythms,

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772. Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar 11;351(6278):1166-71. doi: 10.1126/science.aad3517. PubMed PMID: 26965621.

773. Bigornia SJ, Harris WS, Falcón LM, Ordovás JM, Lai CQ, Tucker KL. The Omega-3 Index Is Inversely Associated with Depressive Symptoms among Individuals with Elevated Oxidative Stress Biomarkers. J Nutr. 2016 Mar 2. pii: jn222562. [Epub ahead of print] PubMed PMID: 26936135.

774. Micó V, Martín R, Lasunción MA, Ordovás JM, Daimiel L. Unsuccessful Detection of Plant MicroRNAs in Beer, Extra Virgin Olive Oil and Human Plasma After an Acute Ingestion of Extra Virgin Olive Oil. Plant Foods Hum Nutr. 2016 Mar;71(1):102-8. doi: 10.1007/s11130-016-0534-9. PubMed PMID: 26872816.

775. Dashti HS, Zuurbier LA, de Jonge E, Voortman T, Jacques PF, Lamon-Fava S, Scheer FA, Kiefte-De Jong JC, Hofman A, Ordovás JM, Franco OH, Tiemeier H. Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study. J Sleep Res. 2016 Feb 9. doi: 10.1111/jsr.12397. [Epub ahead of print] PubMed PMID: 26857552.

776. Das M, Sha J, Hidalgo B, Aslibekyan S, Do AN, Zhi D, Sun D, Zhang T, Li S, Chen W, Srinivasan SR, Tiwari HK, Absher D, Ordovas JM, Berenson GS, Arnett DK, Irvin MR. Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS One. 2016 Jan 25;11(1):e0145789. doi: 10.1371/journal.pone.0145789. eCollection 2016. PubMed PMID: 26808626; PubMed Central PMCID: PMC4726462.

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778. Corella D, Asensio EM, Coltell O, Sorlí JV, Estruch R, Martínez-González MÁ, Salas-Salvadó J, Castañer O, Arós F, Lapetra J, Serra-Majem L, Gómez-Gracia E, Ortega-Azorín C, Fiol M, Espino JD, Díaz-López A, Fitó M, Ros E, Ordovás JM. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovasc Diabetol. 2016 Jan 7;15(1):4. doi: 10.1186/s12933-015-0327-8. PubMed PMID: 26739996; PubMed Central PMCID: PMC4704407.

779. Ordovás JM, Berciano S. Water is life: an evolutionary perspective of hydration-related gene-environment interactions. Nutr Hosp. 2015 Dec 1;32 Suppl 2:10272. doi: 10.3305/nh.2015.32.sup2.10272. PubMed PMID: 26615242.

780. Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JM. Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Adv Nutr. 2015 Nov 13;6(6):648-59. doi: 10.3945/an.115.008623. Print 2015 Nov. Review. PubMed PMID: 26567190; PubMed Central PMCID: PMC4642416.

781. Laclaustra M, Hurtado-Roca Y, Sendin M, Leon M, Ledesma M, Andres E, Fernandez-Ortiz A, Guallar E, Ordovas JM, Casasnovas JA. Lower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men. Nutr Metab Cardiovasc Dis. 2015 Dec;25(12):1095-103. doi: 10.1016/j.numecd.2015.09.007. Epub 2015 Sep 25. PubMed PMID: 26552743.

782. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham LD, Aslibekyan S, Claas SA, Tsai MY, Borecki IB, Kabagambe EK, Ordovás JM, Absher DM, Arnett DK. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Mol Nutr Food Res. 2016 Feb;60(2):410-9. doi: 10.1002/mnfr.201500436. Epub 2015 Nov 23. PubMed PMID: 26518637.

783. Richardson K, Schnitzler GR, Lai CQ, Ordovas JM. Functional Genomics Analysis of Big Data Identifies Novel Peroxisome Proliferator-Activated Receptor γ Target Single

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784. Daimiel L, Ordovás JM, Dávalos A. miRNAs modified by dietary lipids in Caco-2 cells. A microarray screening. Genom Data. 2015 Jun 9;5:171-2. doi: 10.1016/j.gdata.2015.05.011. eCollection 2015 Sep. PubMed PMID: 26484250; PubMed Central PMCID: PMC4584012.

785. Das M, Irvin MR, Sha J, Aslibekyan S, Hidalgo B, Perry RT, Zhi D, Tiwari HK, Absher D, Ordovas JM, Arnett DK. Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study. Front Genet. 2015 Sep 29;6:304. doi: 10.3389/fgene.2015.00304. eCollection 2015. PubMed PMID: 26483836; PubMed Central PMCID: PMC4586504.

786. Blanco-Rojo R, Alcala-Diaz JF, Wopereis S, Perez-Martinez P, Quintana-Navarro GM, Marin C, Ordovas JM, van Ommen B, Perez-Jimenez F, Delgado-Lista J, Lopez-Miranda J. The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial. Diabetologia. 2015 Oct 16. [Epub ahead of print] PubMed PMID: 26474775.

787. Daimiel-Ruiz L, Klett-Mingo M, Konstantinidou V, Micó V, Aranda JF, García B, Martínez-Botas J, Dávalos A, Fernández-Hernando C, Ordovás JM. Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system. Mol Nutr Food Res. 2015 Sep;59(9):1865-78. doi: 10.1002/mnfr.201570094. PubMed PMID: 26387852.

788. Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, van Rooij FJ, Dimitriou M, Raitakari O, Pankow JS, Djoussé L, Province MA, Hu FB, Lai CQ, Keller MF, Perälä MM, Rotter JI, Hofman A, Graff M, Kähönen M, Mukamal K, Johansson I, Ordovas JM, Liu Y, Männistö S, Uitterlinden AG, Deloukas P, Seppälä I, Psaty BM, Cupples LA, Borecki IB, Franks PW, Arnett DK, Nalls MA, Eriksson JG, Orho-Melander M, Franco OH, Lehtimäki T, Dedoussis GV, Meigs JB, Siscovick DS. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015 Nov;102(5):1266-78. doi: 10.3945/ajcn.114.101238. Epub 2015 Sep 9. PubMed PMID: 26354543; PubMed Central PMCID: PMC4625584.

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790. Gomez-Delgado F, Garcia-Rios A, Alcala-Diaz JF, Rangel-Zuñiga O, Delgado-Lista J, Yubero-Serrano EM, Lopez-Moreno J, Tinahones FJ, Ordovas JM, Garaulet M, Lopez-Miranda J, Perez-Martinez P. Chronic consumption of a low-fat diet improves cardiometabolic risk factors according to the CLOCK gene in patients with coronary heart disease. Mol Nutr Food Res. 2015 Dec;59(12):2556-64. doi: 10.1002/mnfr.201500375. Epub 2015 Oct 8. PubMed PMID: 26346429.

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792. Rozati M, Barnett J, Wu D, Handelman G, Saltzman E, Wilson T, Li L, Wang J, Marcos A, Ordovás JM, Lee YC, Meydani M, Meydani SN. Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial. Nutr Metab (Lond). 2015 Aug 7;12:28. doi: 10.1186/s12986-015-0022-5. eCollection 2015. PubMed PMID: 26251666; PubMed Central PMCID: PMC4527272.

793. Saravia G, Civeira F, Hurtado-Roca Y, Andres E, Leon M, Pocovi M, Ordovas J, Guallar E, Fernandez-Ortiz A, Casasnovas JA, Laclaustra M. Glycated Hemoglobin, Fasting Insulin and the Metabolic Syndrome in Males. Cross-Sectional Analyses of the Aragon Workers' Health Study Baseline. PLoS One. 2015 Aug 4;10(8):e0132244. doi: 10.1371/journal.pone.0132244. eCollection 2015. PubMed PMID: 26241903; PubMed Central PMCID: PMC4524641.

794. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. doi: 10.1097/FPC.0000000000000162. PubMed PMID: 26203732; PubMed Central PMCID: PMC4558213.

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796. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM; CHARGE Nutrition Study Group. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015 Aug;38(8):1456-66. doi: 10.2337/dc14-2709. Epub 2015 Jun 17. PubMed PMID: 26084345; PubMed Central PMCID: PMC4512139.

797. Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JM. Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature. Am J Hypertens. 2016 Jan;29(1):132-40. doi: 10.1093/ajh/hpv082. Epub 2015 Jun 4. PubMed PMID: 26045533.

798. Ruiz-Hernandez A, Kuo CC, Rentero-Garrido P, Tang WY, Redon J, Ordovas JM, Navas-Acien A, Tellez-Plaza M. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Clin Epigenetics. 2015 Apr 29;7(1):55. doi: 10.1186/s13148-015-0055-7. eCollection 2015. Review. PubMed PMID: 25984247; PubMed Central PMCID: PMC4433069.

799. Xin XX, Chen Y, Chen D, Xiao F, Parnell LD, Zhao J, Liu L, Ordovas JM, Lai CQ, Shen L. Supplementation with Major Royal Jelly Proteins Increases Lifespan,Feeding and Fecundity in Drosophila. J Agric Food Chem. 2016 Jul 7. [Epub ahead of print] PubMed PMID: 27388939.

800. Delgado-Lista J, Perez-Martinez P, Garcia-Rios A, Alcala-Diaz JF, Perez-Caballero AI, Gomez-Delgado F, Fuentes F, Quintana-Navarro G, Lopez-Segura F, Ortiz-Morales AM, Delgado-Casado N, Yubero-Serrano EM, Camargo A, Marin C, Rodriguez-Cantalejo F, Gomez-Luna P, Ordovas JM, Lopez-Miranda J, Perez-Jimenez F. CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): Rationale, methods, and baseline characteristics: A clinical trial comparing the efficacy of a Mediterranean diet rich in olive oilversus a low-fat diet on cardiovascular disease in coronary patients. Am Heart J. 2016 Jul;177:42-50. doi: 10.1016/j.ahj.2016.04.011. Epub 2016 Apr 27. PubMed PMID: 27297848; PubMed Central PMCID: PMC4910622.

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801. Talavera-Garcia E, Delgado-Lista J, Garcia-Rios A, Delgado-Casado N, Gomez-Luna P, Gomez-Garduño A, Gomez-Delgado F, Alcala-Diaz JF, Yubero-Serrano E, Marin C, Perez-Caballero AI, Fuentes-Jimenez FJ, Camargo A, Rodriguez-Cantalejo F, Tinahones FJ, Ordovas JM, Perez-Jimenez F, Perez-Martinez P, Lopez-Miranda J. Correction: Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study). PLoS One. 2016 Jun 9;11(6):e0157213. doi: 10.1371/journal.pone.0157213. eCollection 2016. PubMed PMID: 27280725; PubMed Central PMCID: PMC4900640.

802. Ferguson LR, De Caterina R, Görman U, Allayee H, Kohlmeier M, Prasad C, Choi MS, Curi R, de Luis DA, Gil Á, Kang JX, Martin RL, Milagro FI, Nicoletti CF, Nonino CB, Ordovas JM, Parslow VR, Portillo MP, Santos JL, Serhan CN, Simopoulos AP, Velázquez-Arellano A, Zulet MA, Martinez JA. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016;9(1):12-27. doi: 10.1159/000445350. Epub 2016 May 12. PubMed PMID: 27169401.

803. Ferguson JF, Allayee H, Gerszten RE, Ideraabdullah F, Kris-Etherton PM, Ordovás JM, Rimm EB, Wang TJ, Bennett BJ; American Heart Association Council on Functional Genomics and Translational Biology, Council on Epidemiology and Prevention, and Stroke Council. Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Jun;9(3):291-313. doi:10.1161/HCG.0000000000000030. Epub 2016 Apr 19. PubMed PMID: 27095829.

804. Talavera-Garcia E, Delgado-Lista J, Garcia-Rios A, Delgado-Casado N, Gomez-Luna P, Gomez-Garduño A, Gomez-Delgado F, Alcala-Diaz JF, Yubero-Serrano E, Marin C, Perez-Caballero AI, Fuentes-Jimenez FJ, Camargo A, Rodriguez-Cantalejo F, Tinahones FJ, Ordovas JM, Perez-Jimenez F, Perez-Martinez P, Lopez-Miranda J. Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patient with Coronary Artery Disease (CordioPrev Study). PLoS One. 2016 Apr 11;11(4):e0153096. doi: 10.1371/journal.pone.0153096. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157213. PubMed PMID: 27064675; PubMed Central PMCID: PMC4827867.

805. Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S, Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen IY, Rotter JI, Wagner MJ, Arnett DK. A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies. Pharmacogenet Genomics. 2016 Jul;26(7):324-33. doi: 10.1097/FPC.0000000000000219. PubMed PMID: 27002377.

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José M. Ordovás - University of Massachusetts Lowell · José M. Ordovás, PhD, (born in Zaragoza, Spain in 1956) is Professor of Nutrition and a Senior Scientist at the USDA-Human