ERRATA Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits Joseph K. Pickrell* (The American Journal of Human Genetics 94, 559–573; April 3, 2014) In this article, the derivation of the likelihood function (Equation 11) is unfortunately incorrect. Throughout the derivation, the ‘‘data’’ are referred to as the set of observed phenotypes y ! . However, the model is for the set of summary statistics. In Equations 5, 10, 11, and 12, y ! should thus instead read b b ! , representing the vector of observed SNP effect sizes. Additionally, in Equation 14, the denominator on the right-hand side is missing a factor of 2. All errors were in the exposition and not in the implementation of the method. The correct equations appear below. The author apologizes for any confusion these errors might have caused. P b b ! ¼ Y M=K k¼1 1 Y k P 0 k þ Y k P 1 k (Equation 5) L b b ! j q ¼ Y M=K k¼1 1 Y k P 0 k þ Y k X K i¼1 p ij P 1 ik (Equation 10) L b b ! j q ¼ Y M=K k¼1 P 0 k " 1 Y k þ Y k X K i¼1 p ik BF i # (Equation 11) l b b ! j q ¼ ln L b b ! j q p X L 1 l¼1 g 2 l þ X L 2 l¼1 l 2 l ! (Equation 12) V i z 1 2N i f i 1 f i (Equation 14) *Correspondence: [email protected] http://dx.doi.org/10.1016/j.ajhg.2014.06.001. Ó2014 by The American Society of Human Genetics. All rights reserved. Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans Saeed Al Turki, Ashok K. Manickaraj, Catherine L. Mercer, Sebastian S. Gerety, Marc-Phillip Hitz, Sarah Lindsay, Lisa C.A. D’Alessandro, G. Jawahar Swaminathan, Jamie Bentham, Anne-Karin Arndt, Jacoba Low, Jeroen Breckpot, Marc Gewillig, Bernard Thienpont, Hashim Abdul-Khaliq, Christine Harnack, Kirstin Hoff, Hans-Heiner Kramer, Stephan Schubert, Reiner Siebert, Okan Toka, Catherine Cosgrove, Hugh Watkins, Anneke M. Lucassen, Ita M. O’Kelly, Anthony P. Salmon, Frances A. Bu’Lock, Javier Granados-Riveron, Kerry Setchﬁeld, Chris Thornborough, J. David Brook, Barbara Mulder, Sabine Klaassen, Shoumo Bhattacharya, Koen Devriendt, David R. FitzPatrick, UK10K Consortium, David I. Wilson, Seema Mital,* and Matthew E. Hurles* (The American Journal of Human Genetics 94, 574–585; April 3, 2014) The following sentence was omitted from the Acknowledgments statement: this work was supported, in part, by British Heart Foundation Grants PG/07/045 and CH/09/003. Additinally, David F. FitzPatrick should have been David R. Fitzpatrick, as it appears here. The authors regret these oversights. *Correspondence: [email protected] (S.M.), [email protected] (M.E.H.) http://dx.doi.org/10.1016/j.ajhg.2014.06.013. Ó2014 by The American Society of Human Genetics. All rights reserved. 126 The American Journal of Human Genetics 95, 126, July 3, 2014

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

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ERRATA

Joint Analysis of Functional Genomic Dataand Genome-wide Association Studies of 18 Human Traits

Joseph K. Pickrell*

(The American Journal of Human Genetics 94, 559–573; April 3, 2014)

In this article, the derivation of the likelihood function (Equation 11) is unfortunately incorrect. Throughout the

derivation, the ‘‘data’’ are referred to as the set of observed phenotypes y!. However, the model is for the set of summary

statistics. In Equations 5, 10, 11, and 12, y! should thus instead read bb!, representing the vector of observed SNP effect

sizes. Additionally, in Equation 14, the denominator on the right-hand side is missing a factor of 2. All errors were in the

exposition and not in the implementation of the method. The correct equations appear below. The author apologizes for

any confusion these errors might have caused.

P� bb!� ¼

YM=K

k¼1

�1�

�P0k þ

YkP1k (Equation 5)

L� bb!j q

�¼YM=K

k¼1

�1�

�P0k þ

XKi¼1

pijP1ik (Equation 10)

L� bb!j q

�¼YM=K

k¼1

P0k

�1�

�þY

XKi¼1

pikBFi

#(Equation 11)

�

l�� bb!j q

�¼ ln L

� bb!j q��

� p

XL1l¼1

g2l þ

XL2l¼1

l2l

!(Equation 12)

Viz1

2Nifi�1� fi

� (Equation 14)

*Correspondence: [email protected]

Rare Variants in NR2F2 CauseCongenital Heart Defects in Humans

Saeed Al Turki, Ashok K. Manickaraj, Catherine L. Mercer, Sebastian S. Gerety, Marc-Phillip Hitz,Sarah Lindsay, Lisa C.A. D’Alessandro, G. Jawahar Swaminathan, Jamie Bentham, Anne-Karin Arndt,Jacoba Low, Jeroen Breckpot, Marc Gewillig, Bernard Thienpont, Hashim Abdul-Khaliq,Christine Harnack, Kirstin Hoff, Hans-Heiner Kramer, Stephan Schubert, Reiner Siebert, Okan Toka,Catherine Cosgrove, Hugh Watkins, Anneke M. Lucassen, Ita M. O’Kelly, Anthony P. Salmon,Frances A. Bu’Lock, Javier Granados-Riveron, Kerry Setchfield, Chris Thornborough, J. David Brook,Barbara Mulder, Sabine Klaassen, Shoumo Bhattacharya, Koen Devriendt, David R. FitzPatrick,UK10K Consortium, David I. Wilson, Seema Mital,* and Matthew E. Hurles*

(The American Journal of Human Genetics 94, 574–585; April 3, 2014)

The following sentence was omitted from the Acknowledgments statement: this work was supported, in part,

by British Heart Foundation Grants PG/07/045 and CH/09/003. Additinally, David F. FitzPatrick should have been

David R. Fitzpatrick, as it appears here. The authors regret these oversights.

*Correspondence: [email protected] (S.M.), [email protected] (M.E.H.)

126 The American Journal of Human Genetics 95, 126, July 3, 2014

mailto:[email protected]

http://dx.doi.org/10.1016/j.ajhg.2014.06.001

mailto:[email protected]

http://dx.doi.org/10.1016/j.ajhg.2014.06.013

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