INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS ... · INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS LINKED TO NEW DIAGNOSTIC TECHNOLOGIES

INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS LINKED TO NEW DIAGNOSTIC TECHNOLOGIES

11th OIE Seminar

New Diagnostic Technologies and International Standard Setting

Dr Elisabeth Erlacher-Vindel Ms Sara Linnane Deputy Head Scientific Editor Scientific and Technical Department Scientific and Technical Department

XVIIth WAVLD Symposium, Saskatoon, 17 June 2015

Outline

Introduction to the OIE

OIE Reference Laboratories and Collaborating Centres

Projects linked to New Diagnostic Technologies

Future Developments

17th WAVLD Symposium, Saskatoon, 17 June 2015


An intergovernmental organisation founded in 1924

preceding the United Nations

Creation of the

Office International

des Epizooties (OIE)

World Organisation

for Animal Health

(OIE)

Creation of the

United Nations

1924 2003 1945

3



Some countries belong to more than one region

36

36

54

30

53

20

Africa 54 – Americas 30 – Asia, the Far East and Oceania 36 – Europe 53 – Middle-East 20

180 Members (2015)

4



5

OIE Headquarters

in Paris (France)

Five Regional

Representations

Eight Sub-Regional

Representations and Sub-Regional

Offices


Improve animal health and welfare worldwide

Transparency of the world

animal disease situation

(including zoonoses)

Collection and dissemination of veterinary

scientific information

(animal disease prevention and

control methods)

Sanitary safety of

international trade of

animals and animal

products

(under the mandate given by

the WTO)

6

Three pillars


Standard Setting

SPS Agreement

Food Safety

CODEX

Plant Health

IPPC

International standard-setting

organisations

Animal Health

OIE

OIE is the WTO reference organisation for international trade in animals and animal products and surveillance and control of animal diseases and zoonoses

Sanitary safety of international trade


Standard setting

8

• Terrestrial • Aquatic

CODES

• Terrestrial • Aquatic

MANUALS


OIE Terrestrial Manual

Terrestrial Manual – structure Divided into four

parts, presented in two volumes:

Part I • 10 introductory chapters

Part 2 • 113 chapters on specific diseases

Part 3 • General Guidelines (include validation)

Part 4 • OIE Reference Experts and disease index

Volume I

Volume II

9


WAHIS*

Information from the

Annual reports

Alert messages for exceptional

epidemiological events & for emerging

diseases

Follow-up of outbreaks notified

& information for 116 OIE-listed diseases

twice a year

•Veterinary Services’ capabilities •Vaccine production •National laboratories •Animal population figures •Human cases for zoonoses

180 countries on line

10

http://www.oie.int/en/animal-health-in-the-world/

Transparency: World Animal Health Information System*

10

Early warning system

Monitoring system


Scientific information

Strengthen the OIE’s network

Support veterinary scientific communities in developing countries by facilitating their involvement

and their ability to create networks

Reference Centres

(301 in 2015) Laboratory Twinning

Specific laboratory

support projects

Disease control

worldwide

Continuously update the international standards of the OIE


More than 300 OIE Reference Centres

Reference Laboratories

• 252 laboratories in 39 Member Countries

• 188 Experts

Collaborating Centres

• 49 centres from 26 Member Countries

• Expertise in a specific sphere of

competence

http

://ph

otos

.new

s.w

isc.

edu

http

://w

ww

.oie

.int

OIE Reference Laboratories and Collaborating Centres


Under the responsibility of an OIE expert • Develop, perform and validate diagnostic tests

• Store and distribute reference reagents

• Conduct laboratory proficiency testing

• Coordinate technical and scientific studies

• Organise and implement technical and scientific training

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OIE Reference Laboratories for animal diseases



List of Reference Laboratories validated annually by the World Assembly of Delegates

Terms of Reference available on the OIE Website

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http://www.oie.int/en/our-scientific-

expertise/reference-laboratories/introduction/


2014 OIE Reference Laboratory Activities

15

Last updated May 2015

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

1. Tests in use

2a. Production of OIE recognised standard reference reagents

2b. Supply of standard reference reagents

3. Production/supply of diagnostic reagents other than OIE-approved

4. Production of vaccines

5. Supply of vaccines

6. Development of new diagnostic methods

7. Development of new vaccines

8. Provision of diagnostic testing

9. Provision of expert advice in technical consultancy

10. Participation in international scientific collaborative studies

11. Collection of epizootiological data

12. Dissemination of epizootiological data

13. Method of dissemination of information

14. Provision of scientific and technical training

15. Maintenance of quality management system according to int'l standards

16. Accreditation by an international accreditation body

17. Maintenance of biosafety and biosecurity

18. Organisation of international scientific meetings

19. Participation of international scientific meetings

20. Exchange information with other OIE labs

21. Proficiency testing with other OIE labs

22. Participation in international scientific collaborative studies

23. Proficiency testing labs other than OIE labs

24. Provision of consultant expertise

95%

5%

2%

64%

4%

4%

20%

4%

57%

69%

56%

69%

65%

92%

58%

78%

64%

92%

15%

64%

79%

40%

33%

53%

39%



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• When two or more OIE Reference Laboratories are designated for the same pathogen, a network must be established. Only OIE Reference Laboratories are accountable to the OIE.

• However other reference laboratories might participate in some of the activities.

• Examples of Networks: FMD, Bluetongue, non-tsetse transmitted trypanosomoses

http://www.oie.int/en/our-scientific-expertise/reference-

laboratories/reference-centre-networks/

http://www.oie.int/en/our-scientific-expertise/reference-laboratories/reference-centre-networks/













Contribute to the development of procedures to update and promote OIE international standards and guidelines

Coordinate scientific studies

Provide technical training

Organise and host scientific meetings in collaboration with the OIE

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Centres of excellence on horizontal topics

OIE Collaborating Centres


2014 OIE Collaborating Centre Activities

18

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

1. Activities within the sphere of competence

2. International harmonisation of regulations

3. Maintenance of a network in same specialty

4. Maintenance of a network in other disciplines

5. Provision of consultant expertise

6. Provision of scientific and technical training

7. Organisation of international scientific meetings

8. Coordination of scientific and technical studies

100%

90%

85%

77%

90%

87%

59%

92%

http://www.oie.int/en/our-scientific-expertise/collaborating-centres/introduction/










Each OIE Laboratory Twinning Project

Is a link between OIE Reference Laboratory or Collaborating Centre (Parent) and national laboratory (Candidate)

Aims to improve expertise and diagnostic capacity with eventual aim of achieving OIE Reference Laboratory designation

Should be sustainable once the project is over

The Laboratory Twinning Programme


http://www.oie.int/en/support-

to-oie-members/laboratory-

twinning/

Twinning

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http://www.oie.int/en/support-to-oie-members/laboratory-twinning/











24 projects completed

34 projects underway

12 projects approved and waiting to start

The three most popular topics are:

• Avian influenza and Newcastle disease (10)

• Brucellosis (8)

• Rabies (6)

Status May 2015

21


Performance of Veterinary Services and Laboratories : PVS Pathway

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http://www.oie.int/en/support-to-oie-members/pvs-pathway/












OIE National Veterinary Laboratory Focal Points

Serve as focal points for the OIE on topics related to veterinary laboratories

Create and maintain national laboratory network

Need laboratory expertise and knowledge of management and administration

Operate under the authority of the OIE Delegate at the country level

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Performance of Veterinary Services and Laboratories

17th WAVLD Symposium, Saskatoon, 17 June 2015 24

Reference Laboratories and Collaborating Centres: new activities

New diagnostic technologies and technology platform


December 2012 New diagnostic technologies and technology platform:

Brainstorming Group on New Approaches to Diagnosis: Applied Genomics

White Paper: High-throughput Sequencing in Veterinary Infection Biology and Diagnostics

S. Belák et al., (2013). High-throughput sequencing in veterinary infection biology and diagnostics. Rev. sci. tech. Off. int. Epiz., 32 (3), 893–915.

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June 2013: 10th OIE/WAVLD Seminar

New Approaches to Diagnosis: Opportunities

and Challenges held during the

16th WAVLD Symposium, Berlin, Germany (5–8 June 2013)

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http://www.oie.int/eng/WAVLD/ presentations.htm

http://www.oie.int/eng/WAVLD/presentations.htm




October 2014 New diagnostic technologies and technology platform:

THIRD GLOBAL CONFERENCE OF OIE REFERENCE CENTRES: “Challenges and expectations for the future”

Incheon, Seoul (Rep. of Korea), 14-16 October 2014

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Pilot Project presented:

OIE Platform for the Collection and Management of Genomic Sequences in Animal Health

Develop an approach and design for an open access database relating to animal diseases and pathogens linked to food

Develop standards for the management of high-throughput sequencing, bioinformatics and computational genomics (HTS-BCG)

=> with the support of OIE Reference Centres

October 2014 : Third Global Conference of OIE Reference Centres

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November 2014 New diagnostic technologies and technology platform:

The ad hoc Group on HTS-BCG

Began work on some of the components of the project in November 2014.

Two actions are required to progress in parallel:

1. advance the OIE pilot project

2. develop OIE standards on this topic

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Resolution No. 33:

High Throughput Sequencing, Bioinformatics and Computational Genomics (HTS-BCG)

Recommendations:

1. The OIE develop and update OIE standards and guidelines related to HTS-BCG….

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May 2015 OIE General Session of the World Assembly of Delegates:


Resolution No. 33

2. The OIE establish a platform for the collection and management of partial and complete genomic sequences (including genotype assignment) with the aim to integrate the reporting of genomic sequence data into the OIE World Animal Health Information System (WAHIS)

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Resolution No. 33

3. The OIE address the challenges and opportunities to the OIE Member Countries’ Veterinary Services posed by these new technologies

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May 2015 OIE General Session of the World Assembly of Delegates



Technical Item on

The Use of Information Technology in Animal Health Management, Disease Reporting, Surveillance, and Emergency Response

Presented by Tammy R. Beckham, Institute for Infectious Animal Diseases, Texas A&M University, College Station, TX, USA

Corresponding Resolution 35 adopted

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Beverly Schmitt

(President)

Franck Berthe (1st Vice

President)

Hualan Chen

(2nd Vice President)

Anthony Fooks

(Member)

Mehdi El Harrak

(Member)

Peter Daniels

(Member)

Election of the OIE Biological Standards Commission


Thank you for your attention !

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www.oie.int

12 rue de Prony, 75017 Paris, France

Documents

INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS ... · INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS LINKED TO NEW DIAGNOSTIC TECHNOLOGIES