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  • Introduction to Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging

    PSY 992, Section 601 # of Credits: 3

    http://www.msu.edu/~zhuda

    Meeting date and time: g Tuesday and Thursday: 10:20-11:40 AM

    346 Giltner Hall

    Tentative office hours: Tuesday and Thursday:12 PM - 1 PM

    358 Giltner Hall

    David C. Zhu, Ph.D. Associate Professor of Psychology and Radiology

    Cognitive Imaging Research Center

  • For undergraduate students, please talk with me.

  • Grading

    Grading will be based on:

    1 Att d L t /Di i i (10%)1. Attend Lecture/Discussion sessions. (10%)

    2. Attend Lab sessions. (10%)

    3. Homework assignments. (50%)

    4. Project: Students will help to design and implement an fMRI project. Pilot data will be

    ll t d d i th f thi t d St d tcollected during the course of this study. Students will analyze and summarize the results as their final project. (30%)

  • Traditional Imaging

    T1-weighted

    T2-weighted

  • Blood flow Cerebral blood flow (perfusion)(perfusion)

  • Ventricle movement

    Cerebrospinal fluid dynamics

    Zhu DC, Xenos M, Linninger AA and Penn RD. D i f l t l t i l d b i l fl id iDynamics of lateral ventricle and cerebrospinal fluid in normal and hydrocephalic brains. J Magn Reson Imaging. 2006;24:756-770.

  • Carotid Plaque Hemorrhage Detection and Characterization

    ith 3D SHINE

    ≥ 28 ms T2*

    with 3D SHINE

    14 ms

    21 ms

    3D SHINE & T2* map 3D SHINE & T2* map

    14 ms

    7 ms

    0 ms

    Type II

    (b) (c)(a)

    Type I

    ( ) ( )

    Zhu DC, Vu AT, Ota H, DeMarco JK. Magn Reson Med. 2010;64:1341-1351.

  • The following images show the brain activation when a subject watched movies and pictures:

    The following images show the brain activation when you tapped the fingers of your left hand:

    Motor area

    M tMotor area

  • The following movie shows the brain activation h bj h d i i dwhen a subject watched movies or pictures and

    pressed his finger at the same time:

  • A contrast study of scene vs face base on a group of 14 subjects:

    Scene Processing

    A contrast study of scene vs. face base on a group of 14 subjects: Red and yellow regions show preferential activation to scene. Blue regions show preferential activation to face.

    H d JM L CL Zh DC F ll S d ti ti thHenderson JM, Larson CL, Zhu DC. Full Scenes produce more activation than close-up scenes and scene-diagnostic objects in parahippocampal and retrosplenial cortex: an fMRI study. Brain Cogn. 2008;66:40-49.

  • Scene Processing

    The following regions show preferential activation of indoor over outdoor scenes based on group analysis of 17 subjects:

    Henderson JM, Larson CL, Zhu DC. Cortical activation to indoor versus outdoor scenes: an fMRI study. Exp Brain Res. 2007;179:75-84.

  • The following regions show preferential activation of

    Emotional Processing

    g g p downward triangles over upward triangles based on group analysis of 17 subjects:

    Larson CL, Aronoff J, Sarinopoulos IC, Zhu DC. Recognizing threat: a simple geometric shape activates neural circuitry for threat detection. J Cogn Neurosci. 2009 Aug;21(8):1523-35.

  • Left TPJ activity in verbal working memory: Implications for storage- and sensory-specific models of short term memory

    1 1

    0.4

    0.6

    0.8

    1

    High Object

    High Verbal

    Low Object

    Low Verbal 0.4

    0.6

    0.8

    1a Left IFG/MFG d SMAd

    t s ig

    na l c

    ha ng

    e

    t s ig

    na l c

    ha ng

    e

    1

    ‐0.2

    0

    0.2

    0 4 8 12 16 20 24 28 32 36 40

    Low Verbal

    ‐0.2

    0

    0.2

    0 4 8 12 16 20 24 28 32 36 40

    1

    Pe rc

    en t

    Pe rc

    en t

    Enc Mt Ret Enc Mt Ret

    0.4

    0.6

    0.8

    1

    0.4

    0.6

    0.8

    1 b Left motor e Left insula/IFG

    nt s

    ig na

    l c ha

    ng e

    nt s

    ig na

    l c ha

    ng e

    ‐0.2

    0

    0.2

    0 4 8 12 16 20 24 28 32 36 40 ‐0.2

    0

    0.2

    0 4 8 12 16 20 24 28 32 36 40a f

    Pe rc

    en

    Pe rc

    en

    Enc Mt Ret En c Mt

    Re t

    f Right cerebellum

    Ravizza SM, Hazeltine E, Ruiz S, Zhu DC. Neuroimage. 2011;55:1836-46.

  • Flanker Study: “>>> < >>> - >>>>>>>”, “Incongruent Congruent” Contrast

    Aging Study

    “Incongruent – Congruent” Contrast

    Investigate the network for interference resolution.

    6 5

    >

    (voxel based p ≤ 0.005, whole brain corrected p ≤ 0.021)

    5 4 3 2 1 0 -1 -2

    Younger adults Older adults

    2 -3 -4 -5 6-6<

    Zhu DC, Zacks RT, Slade JM. Brain activation during interference resolution in young and older adults: an fMRI study. Neuroimage. 2010;50:810-817.

  • Diffusion Tensor Imaging

  • The Integration of Structural (DTI) and

    Seed Region #1: pC/rsp (posterior cingulate/retrosplenial cortex)

    Functional (Resting-State fMRI) Connectivity Analyses

    Group Integration (17 subjects): pC/rsp( j ) Whole-brain corrected P < 0.0325 for fMRI.

    pC/rsp

    Mean structural normalized connectivity distribution > 10-4

    MeFC/ACC (Medial Frontal Cortex/ Anterior Cingulate Cortex)

    distribution > 10 4.

    Zhu DC and Majumdar S. Journal of Neuroimaging. In Press.

  • A happy volunteer after surviving an fMRI session

  • Data acquisition Pulse sequence development

    Type of Research Focus

    - Pulse sequence development - Image reconstruction technique development - Coil development

    Data analysis - Statistical method - Data mining - Resting state

    Visualization - Pattern recognition - Human-computer interfacesHuman computer interfaces

    Applications - Normal aging Resting state Alzheimer- Normal aging, Resting state, Alzheimer. -Visual, Language, Executive processing, Memory - …………

  • http://www.circ.msu.edu

    Investigators

  • How would I get around to start an fMRI project?How would I get around to start an fMRI project?

  • Engineering ProcessEngineering Process

    Cognitive Neuroscience Question

    fMRI Q ti

    Experimental Design

    fMRI Question Looping

    D t A i iti

    Pilot Data

    F ll

    Data Analysis

    Data AcquisitionFull

    Time & $

  • Experimental Design

    Implementation

    Quality Assurance (QA)

    iIntegration Test

    First Subjectj

    Review Result

    Three or Four more Subjects

    Evaluate Preliminary ResultsEvaluate Preliminary Results

    Full data collection

  • Some Paper Works for a New fMRI Project

    • IRB approval.

    • Reviewed by the MRI Review Committee in

    Radiology. Please contact Scarlett Doyle (our MR

    research technologist) for paper work.

  • S f tS f tSafetySafety

  • Reading assignment for this week:

    Chapters 1-2Chapters 1 2.