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, w e i v e R & h c r a e s e R a m r a h P f o l a n r u o J l a n o i t a n r e t n I c e D ( 1 ; 2 1 0 2 8: )6- 3 1 a d a m a h T h s e r a N ) 8 ( 1 ; 2 1 0 2 R R P J I , l a . t e 6 e R h c r a e s e l c i t r A d n a n o i t a c i r b a F o r t i v n I e n i p a r i v a N f o t e l b a T e r o C x i r t a M f o n o i t a u l a v E a c i s a h P i B A s l a u D - m e t s y S y r e v i l e D t n e n o p m o C *N h s e r a T a d a m a h P , h t n a h s a r K r a m u K . B , h t a r a h DS , h t n a k i r C y r a h d w o h . P , s c i t u e c a m r a h P f o t n e m t r a p e D S e e r D a h t t a I e t u t i t s n f o P y c a m r a h S , a d u g i r e h I , m u n t a p i m h a r b H , , d a b a r e d y . a i d n I _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ T C A R T S B A h c r a e s e r t n e s e r p f o o t t o m n i a m e h T r e p u s g n i s u e n i p a r i v a N f o t e l b a t c i s a h p l a u d a p o l e v e d o t s a w s a h c u s s r e m y l o p e l b i c s i m m i r e t a w d n a r e y a l e s a e l e r t s a f e h t r o f e s o l u l l e c e n i l l a t s y r c o r c i m t n a t a r g e t n i s i d r e y a l g n i n i a t s u s e h t r o f m u g m u h t n a X , e s o l u l l e c l y h t E f o e d a m t e l b a t t n e n o p m o c l a u d A . e s a e l e r d e n i a t s u s a e r o c e h t h t o B . n o i s s e r p m o c t c e r i d y b d e r a p e r p s a w t a o c d e t a l u b a t e s a e l e r e t a i d e m m i n a d n a e r o c d e t a l u b a t . e n i p a r i v a N g u r d l e d o m a d e n i a t n o c t a o c e h t d n a . s r e m y l o p h t i w d e v e i h c a s a w t c e f f e e s a e l e r d e n i a t s u s e h T l y p o r p y x o r d y h ) C M P H ( e k i l e s a e l e r e h t n i a t s u s o t ) G X ( m u g n a h t n a X d n a e s o l u l l e c l y h t E ) C E ( , e s o l u l l e c l y h t e m n i e h T . g u r d e n i p a r i v a N f o - e s a e l e r c i s a h p i b d e r i s e d e h t d e w o h s s t e l b a t e s e h t m o r f e l i f o r p e s a e l e r g u r d o r t i v d s a w t n e n o p m o c g n i s a e l e r t s a f e h t e r e h w , e n i p a r i v a N f o r o i v a h e b n i g u r d e h t d n a s e t u n i m 0 3 n i h t i w d e v l o s s i n a h t n a X t a h t d e v r e s b o s a w t I . s t e l b a t x i r t a m e h t m o r f s r u o h 2 1 f o d o i r e p a r e v o d e s a e l e r s a w t e l b a t e r o c e h t d e h t f o e s a e l e r e h t d e y a l e d t i s a e s o l u l l e c l y h t e d n a C M P H n a h t t n e g a g n i d r a t e r e s a e l e r r e t t e b a s i m u g r o f g u r n o t n e d n e p e d s i e l i f o r p e s a e l e r e h t t a h t s w o h s t s e t n o i t u l o s s i d e h t h t i w d e n i a t b o s t l u s e r e h T . s r h 5 1 n a h t e r o m . t e l b a t e r o c e h t n i r e m y l o p f o t n u o m a d n a e p y t e h t s d r o w y e K m e t s y s t n e n o p m o c l a u D : x , e n i p a r i v a n , e s a e l e r e t a i d e m m i , e s o l u l l e c l y h t e . m u g n a h t n a 2 1 0 2 t c O 6 2 d e v i e c e R m r o f d e s i v e r n i d e v i e c e R 2 1 0 2 v o N 3 1 d e t p e c c A 2 1 0 2 v o N 1 1 e c n e d n o p s e r r o C r o f r o h t u A * h s e r a N a d a m a h T , a d u g i r e h S , y c a m r a h P f o e t u t i t s n I a h t t a D e e r S , s c i t u e c a m r a h P f o t n e m t r a p e D m u n t a p i m h a r b I 0 1 5 1 0 5 , . a i d n I , h s e d a r P a r h d n A , d a b a r e d y H E- : l i a m m o c . l i a m g @ a d a m m a h t h s e r a n _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ N O I T C U D O R T N I e h t s i n o i t a r t s i n i m d a g u r d f o e t u o r l a r o e h T f o d o h t e m d e r r e f e r p d n a n o m m o c t s o m f o e s a e d n a e c n e i n e v n o c s t i o t e u d y r e v i l e d s i g u r d e h t f i c i t a m e l b o r p s i t i t u b n o i t s e g n i r o e l b u l o s r e t a w y l r o o p a h r o o p g n i v e n a r b m e m [ y t i l i b a e m r e p ] 1. f o e s a e l e r t s a f s e v i g s t e l b a t e s a e l e r e t a i d e m m I n o i t c a f o t e s n o d i p a r e d i v o r p o t s g u r d o t s l i a f t u b s c i t e n i k r e d r o o r e z g n i w o l l o f e l i h W . n o i t c a f o n o i t a r u d g n o l e d i v o r p s m r o f e g a s o d e s a e l e r l o r t n o c l a n o i t n e v n o c y a l e d y b g u r d c i t u e p a r e h t f o e s a e l e r e h t o n o d d n a s c i t e n i k r e d r o o r e z g n i w o l l o f t n o i t c a f o t e s n o d i p a r e d i v o r p ] 2 [ . i b a n I - r e y a l f o r e y a l e s a e l e r e t a i d e m m i e h t , n o i t a r u g i f n o c i b e h t - g n i d a o l e h t s a d e k r o w s a h t e l b a t r e y a l a h r e y a l e s a e l e r d e n i a t s u s e h t d n a e s o d s g u r d a m s a l p c i t u e p a r e h t e h t d e n i a t n i a m e m i t d e g n o l o r p r o f n o i t a r t n e c n o c . y l e v i t a l e r A n e t f o s i g u r d a f o l e v e l a m s a l p t n a t s n o c n o i t a r t n e c n o c g u r d e h t n i a t n i a m o t d e r r e f e r p s i t i r e v e w o H . w o d n i w c i t u e p a r e h t e h t n i h t i w i v n e e h t e s u a c e b e v e i h c a o t t l u c i f f i d t n e m n o r s e i r a v n o i t p r o s b a r o d n a n o i s u f f i d g u r d r o f ) I G ( l a n i t s e t n i o r t s a g e h t g n o l a t c a r t n o d e s a B . y r e v i l e d c i s a h p i b , s n o i t a r e d i s n o c e s e h t 2 t a g u r d a e s a e l e r o t d e n g i s e d e r a s m e t s y s f o s d o i r e p t n e r e f f i d 2 n i r o s e t a r t n e r e f f i d k c i u q r e h t i e e r a y e h t : e m i t r o w o l s / . k c i u q / w o l s m e t s y s e s a e l e r w o l s / k c i u q A e s a e l e r g u r d f o t s r u b l a i t i n i n a s e d i v o r p f o ) y l l a e d i ( e t a r t n a t s n o c a y b d e w o l l o f s a e l e r f o d o i r e p d e n i f e d a r e v o e [ e m i t ] 3. e h t s i , e n o n i p e z a i d o d i r y p i d a , e n i p a r i v e N e r i t n a f o s s a l c a f o r e b m e m c i p y t o t o r p l a r i v o r t

International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

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Page 1: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 6

eR hcraes elcitrA

dna noitacirbaF ortivnI eniparivaN fo telbaT eroC xirtaM fo noitaulavE a cisahP iB A slauD - metsyS yrevileD tnenopmoC

*N hsera T adamah P , htnahsar K ramu K. B , htarah D S , htnakir C yrahdwoh .P

,scituecamrahP fo tnemtrapeD S eer D ahtta I etutitsn fo P ycamrah S , adugireh I , muntapimharb H , ,dabaredy.aidnI

_____________________________________________________________________________________________________________________________ _________________________________________________________________ __________________________________________________________

TCARTSBA hcraeser tneserp fo ottom niam ehT repus gnisu eniparivaN fo telbat cisahp laud a poleved ot saw

sa hcus sremylop elbicsimmi retaw dna reyal esaeler tsaf eht rof esolullec enillatsyrc orcim tnatargetnisidreyal gniniatsus eht rof mug muhtnaX ,esolulleclyhtE fo edam telbat tnenopmoc laud A . esaeler deniatsus a

eroc eht htoB .noisserpmoc tcerid yb deraperp saw taoc detalubat esaeler etaidemmi na dna eroc detalubat.eniparivaN gurd ledom a deniatnoc taoc eht dna . sremylop htiw deveihca saw tceffe esaeler deniatsus ehT

lyporpyxordyh )CMPH( ekil esaeler eht niatsus ot )GX( mug nahtnaX dna esolullec lyhtE )CE( ,esolulleclyhtemni ehT .gurd eniparivaN fo - esaeler cisahpib derised eht dewohs stelbat eseht morf eliforp esaeler gurd ortiv

d saw tnenopmoc gnisaeler tsaf eht erehw ,eniparivaN fo roivaheb ni gurd eht dna setunim 03 nihtiw devlossi nahtnaX taht devresbo saw tI .stelbat xirtam eht morf sruoh 21 fo doirep a revo desaeler saw telbat eroc eht

d eht fo esaeler eht deyaled ti sa esolullec lyhte dna CMPH naht tnega gnidrater esaeler retteb a si mug rof gur no tnedneped si eliforp esaeler eht taht swohs tset noitulossid eht htiw deniatbo stluser ehT .srh51 naht erom

.telbat eroc eht ni remylop fo tnuoma dna epyt eht

sdrowyeK metsys tnenopmoc lauD : x ,eniparivan ,esaeler etaidemmi ,esolulleclyhte .mug nahtna

2102 tcO 62 devieceR mrof desiver ni devieceR 2102voN 31 detpeccA 2102voN 11

ecnednopserroC rof rohtuA* hseraN adamahT

,adugirehS ,ycamrahP fo etutitsnI ahttaD eerS ,scituecamrahP fo tnemtrapeD muntapimharbI 015105 ,.aidnI ,hsedarP arhdnA ,dabaredyH

E- :liam moc.liamg@adammahthseran _____________________________________________________________________________________________________________________________

NOITCUDORTNI eht si noitartsinimda gurd fo etuor laro ehT fo dohtem derreferp dna nommoc tsom fo esae dna ecneinevnoc sti ot eud yreviled si gurd eht fi citamelborp si ti tub noitsegni

ro elbulos retaw ylroop ah roop gniv enarbmem [ ytilibaemrep ]1 .

fo esaeler tsaf sevig stelbat esaeler etaidemmI noitca fo tesno dipar edivorp ot sgurd ot sliaf tub scitenik redro orez gniwollof elihW .noitca fo noitarud gnol edivorp smrof egasod esaeler lortnoc lanoitnevnoc

yaled yb gurd cituepareht fo esaeler ehton od dna scitenik redro orez gniwollof t

noitca fo tesno dipar edivorp ]2[ . ib a nI - reyal fo reyal esaeler etaidemmi eht ,noitarugifnoc

ib eht - gnidaol eht sa dekrow sah telbat reyalah reyal esaeler deniatsus eht dna esod s

gurd amsalp cituepareht eht deniatniamemit degnolorp rof noitartnecnoc . ylevitaler A

netfo si gurd a fo level amsalp tnatsnoc noitartnecnoc gurd eht niatniam ot derreferp si ti revewoH .wodniw cituepareht eht nihtiw

ivne eht esuaceb eveihca ot tluciffid tnemnor seirav noitprosba ro dna noisuffid gurd rof

)IG( lanitsetniortsag eht gnola tcart no desaB . yreviled cisahpib ,snoitaredisnoc eseht 2 ta gurd a esaeler ot dengised era smetsys fo sdoirep tnereffid 2 ni ro setar tnereffid

kciuq rehtie era yeht :emit ro wols/ .kciuq/wols metsys esaeler wols/kciuq A

esaeler gurd fo tsrub laitini na sedivorp fo )yllaedi( etar tnatsnoc a yb dewollof

saeler fo doirep denifed a revo e [ emit ]3 . eht si ,enonipezaidodirypid a ,enipariveN

eritna fo ssalc a fo rebmem cipytotorp larivort

Page 2: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 7

edisoelcunnon sa ot derrefer sdnuopmoc si enipariveN .srotibihni esatpircsnart esrever evititepmocnon evitceles dna tnetop a ,emyzne esatpircsnart esrever eht fo rotibihni eht rof tegrat cituepareht tnatropmi na

VIH fo tnemtaert - a ehT .noitcefni 1 fo ytivitc etalpmet htiw etepmoc ton seod enipariven ti seod ron ,setahpsohpirt edisoelcun ro

VIH tibihni - fo yna ro esatpircsnart esrever 2 detelpmoc nI .sesaremylop AND namuh eht detartsnomed sah enipariven ,seiduts lacinilc

a htob ytivitca larivorteritna yparehtonom s edisoelcun htiw noitanibmoc ni dna elbaruovaf a sah enipariveN ...seugolana ylediw semoceb ,eliforp citenikocamrahp gnidulcni seussit ydob tuohguorht detubirtsid ni evitca si dna ,metsys suovren lartnec eht

gm 002 fo esod laro na ta tluda eht keew owt a retfa yliad eciwt deretsinimda

dael - on era erehT .yad rep gm 002 fo esod nigurd tnacifingis - htiw deton snoitcaretni gurd

esatpircsnart esrever edisoelcun eht enipariven esuaceb ,revewoh ;srotibihni eht ,semyzneosi 054P emorhcotyc secudni

erruc yam srotibihni esaetorp desu yltn ..msilobatem fo setar dipar erom ogrednu nehw dipar si enipariven ot ecnatsiseR si siht tub yparehtonom a sa deretsinimda tnaveler yllacinilc ssel edam dna deretla htiw noitanibmoc ni nevig si enipariven nehw

o erom ro eno enipariveN .sedisoelcun eht f htiw palrevo ton seod taht eliforp ytefas a sah tsom eht ,seipareht larivorteritna rehto

tnemtaert nommoc - gnieb noitcaer gnitimil larivorteritna evitca na si enipariveN .hsar doog dna noitubirtsidoib tnellecxe htiw tnega

netop rehto htiw noitanibmoc ni esu rof lait VIH fo murtceps eht ssorca slarivorteritna

.snoitalupop detceles ni sa llew sa esaesid 4[ ]. non eht ni sllaf enipariveN - esrever edisoelcun

fo ssalc )ITRNN( rotibihni esatpircsnartlarivorteritna . non dna edisoelcun htoB -

eht ,tegrat emas eht tibihni sITR edisoelcunesatpircsnart esrever laitnesse na ,emyzne

otni ANR lariv sebircsnart hcihw emyzne larivU .AND ta dnib hcihw ,sITR edisoelcun ekiln

dnib sITRNN ,etis evitca s'emyzne eht eht morf yawa etis tcnitsid a ta yllaciretsolla

.tekcop ITRNN eht demret etis evitca 5[ ].

eno gniniatnoc telbat reyal elbuod A eno dna tnemtrapmoc esaeler etaidemmi

esaeler niatsus hcus segatnavda sreffo reyal reyal gnisaeler tsaf morf esaeler gurd eht sa noitartnecnoc doolb eht ni esir a ot sdael si level doolB .noitca fo tesno eht gnitaitini si gurd eht sa etats ydaets ta deniatniam eht suhT .reyal gniniatsus eht morf desaeler

eved tneiciffus eb lliw telbat elgnis depol ti dna ,yad rep stelbat eerht ot owt fo daetsni dna ecnailpmoc tneitap esaercni osla lliw sekam siht oS .ycaciffe cituepareht

ENIPARIVAN na cisahpib rof etadidnac laedi gurd [ yreviled ]5 .

SDOHTEM & SLAIRETAM ,ENIPARIVAN elpmas detfig a deniatbo morf

SGURD ORETEH DABAREDYH , AIDNI , . orciMesolullec enillatsyrc , esollemrac ssorC

M 004 K CMPH ,muidos , esolullec lyhtE , mug nahtnaX . fo erew desu slairetam eht llA

morf derucorp dna edarg lacitylanalaicremmoc secruos .

:dohteM latnemirepxE .1 esaeler wols fo noitalumroF

tnenopmoc deraperp erew stelbat eroC fo serutxim morf eniparivaN xirtam dna

lyhte ,CMPH ekil tnega gnillortnoc tcerid yb mug nahtnaX dna esolullec erew slairetam eht llA .noisserpmoc stelbat dna hsem 021 hguorht deveis noisserpmoc tcerid yb deraperp erew

6 gnisu dohtem a ni sehcnup talf mmnihcam gnihcnup telbat yrator .e

.2 tnenopmoc esaeler tsaf fo noitalumroF deniatnoc tnenopmoc esaeler tsaf ehT

gurd ledom eniparivaN enillatsyrcorciM . desu saw )201 HP lecivA( esolullec dna noitcapmoc doog sti fo esuaceb .seitreporp noitargetnisid a sa desu saw muidos esollemracssorC

epus etaidemmi na niatbo ot tnargetnisid r.gurd eht fo esaeler

.3 tnenopmoc laud fo noitaraperP: metsys yreviled

laud ehT - saw metsys yreviled tnenopmoc rellams a gnisserpmoc yb deraperp htiw ,eroc lartnec a gnimrof ,telbat xirtam

atnoc erutxim redwop a tsaf eht gnini reggib a ecudorp ot tnenopmoc gnisaeler eht fo noitaraperp eht roF .telbat

Page 3: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 8

eht fo eid eht ,metsys yreviled wols/kciuq yllaunam dellif saw enihcam gnitelbat tsaf eht fo stnuoma dehgiew eht htiw telbat eroc eht dna tnenopmoc esaeler

( 1 elbaT ) fo flaH .noisserpmoc ot roirp eht otni tup saw redwop gnisaeler tsaf eht ertnec eht no ,deb redwop a ekam ot eid nehT .decalp saw telbat eroc a hcihw fo ot dedda saw redwop eht fo flah rehto eht

snoitalumrof ehT .telbat eroc eht revoc epyt eht ni dereffid fo noitartnecnoc dna

eht fo noitaraperp eht ni desu remylop telbat eroc desserpmoC .telbat eroc tcerid yb deraperp erew smetsys

talf htiw ,noisserpmoc - dna sehcnup pit31 fo seid - gnisu retemaid mm yrator

[ enihcam gnihcnup telbat ]5 .

fo noitisopmoC :1 elbaT )gm( metsys tnenopmoc laud

.S ON 1F 2F 3F 4F 5F 6F

etaidemmI esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 ssorC

esollemracmuidos

05 05 05 05 05 05

orciM enillatsyrc

esolullec

052 052 052 052 052 052

deniatsuS esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 K004 CMPH 05 x x 001 x x

esolulleclyhtERL

x

05 x x 001 x

mug muhtnaXRL

x x 05 x x 001

N fo hparg dradnatS : enipariva

0500.010.0510.020.0520.030.0530.040.0

1 2

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 8

eht fo eid eht ,metsys yreviled wols/kciuq yllaunam dellif saw enihcam gnitelbat tsaf eht fo stnuoma dehgiew eht htiw telbat eroc eht dna tnenopmoc esaeler

( 1 elbaT ) fo flaH .noisserpmoc ot roirp eht otni tup saw redwop gnisaeler tsaf eht ertnec eht no ,deb redwop a ekam ot eid nehT .decalp saw telbat eroc a hcihw fo ot dedda saw redwop eht fo flah rehto eht

snoitalumrof ehT .telbat eroc eht revoc epyt eht ni dereffid fo noitartnecnoc dna

eht fo noitaraperp eht ni desu remylop telbat eroc desserpmoC .telbat eroc tcerid yb deraperp erew smetsys

talf htiw ,noisserpmoc - dna sehcnup pit31 fo seid - gnisu retemaid mm yrator

[ enihcam gnihcnup telbat ]5 .

fo noitisopmoC :1 elbaT )gm( metsys tnenopmoc laud

.S ON 1F 2F 3F 4F 5F 6F

etaidemmI esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 ssorC

esollemracmuidos

05 05 05 05 05 05

orciM enillatsyrc

esolullec

052 052 052 052 052 052

deniatsuS esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 K004 CMPH 05 x x 001 x x

esolulleclyhtERL

x

05 x x 001 x

mug muhtnaXRL

x x 05 x x 001

N fo hparg dradnatS : enipariva

x400.0 = y999.0 = ²R

3 4 5 6 7

noitartnecnoc

ecnabrosba

)ecnabrosba( raeniL

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 8

eht fo eid eht ,metsys yreviled wols/kciuq yllaunam dellif saw enihcam gnitelbat tsaf eht fo stnuoma dehgiew eht htiw telbat eroc eht dna tnenopmoc esaeler

( 1 elbaT ) fo flaH .noisserpmoc ot roirp eht otni tup saw redwop gnisaeler tsaf eht ertnec eht no ,deb redwop a ekam ot eid nehT .decalp saw telbat eroc a hcihw fo ot dedda saw redwop eht fo flah rehto eht

snoitalumrof ehT .telbat eroc eht revoc epyt eht ni dereffid fo noitartnecnoc dna

eht fo noitaraperp eht ni desu remylop telbat eroc desserpmoC .telbat eroc tcerid yb deraperp erew smetsys

talf htiw ,noisserpmoc - dna sehcnup pit31 fo seid - gnisu retemaid mm yrator

[ enihcam gnihcnup telbat ]5 .

fo noitisopmoC :1 elbaT )gm( metsys tnenopmoc laud

.S ON 1F 2F 3F 4F 5F 6F

etaidemmI esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 ssorC

esollemracmuidos

05 05 05 05 05 05

orciM enillatsyrc

esolullec

052 052 052 052 052 052

deniatsuS esaeler

stnenopmoc

eniparivaN 001 001 001 001 001 001 K004 CMPH 05 x x 001 x x

esolulleclyhtERL

x

05 x x 001 x

mug muhtnaXRL

x x 05 x x 001

N fo hparg dradnatS : enipariva

noitartnecnoc

ecnabrosba

)ecnabrosba( raeniL

Page 4: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 9

fo noitaulavE :stelbaT ( T ni detsil elba 2 : )

noitairaV thgieW erew hctab hcae morf stelbat )02( ytnewT na no )mg( smarg ni dehgiew yllaudividni ,thgiew egareva ehT .ecnalab lacitylana

dradnats dradnats evitaler dna noitaived telbat ehT .detroper erew noitaived detsujda ylbatius saw enihcam noisserpmoc

lbat ecudorp ot [ thgiew mrofinu fo ste ]6 . ssenkciht telbaT

saw )mm( sertemillim ni ssenkciht ehT dehgiewerp 01 rof yllaudividni derusaem

stelbat a gnisu yb elbatrop tterrats dnah laid dradnats ,ssenkciht egareva ehT .retemorcim

noitaived dradnats evitaler dna noitaived [ detroper erew ]6 .

ssendrah telbaT yeK a gnisu derusaem saw ssendrah telbaT eht fo htgnerts gnihsurc ehT .retset ssendrah

elbat 01 ssenkciht dna thgiew nwonk htiw st dna )PK( dnopolik ni dedrocer saw hcae fo ,snoitaived dradnats ,ssendrah egareva eht erew snoitaived dradnats evitaler dna ta dekcehc saw ssendrah stelbaT .detroper ssecorp noisserpmoc eht gnirud dna trats eht

lortnoc ot pecca na telbat fo egnar elbat[ ssendrah ]6 .

stinu egasod fo ytimrofinU PSU eht ot gnidrocca dessessa saw sihT

rof stnemeriuqer ehT .ytimrofinu tnetnoc eht fi stnemeriuqer PSU eht steem hctab eht fo hcae ni tneidergni evitca eht fo tnuoma

58 fo egnar eht nihtiw seil stelbat detset 01 %511ot ssel si DSR eht dna mialc lebal eht fo %

6 ot lauqe ro naht PSU eht ot gnidroccA .%retirc ,tem ton si snoitidnoc eseht fo eno fi ,ai

toN .detset eb ot deen stelbat 02 lanoitidda na eb dluohs detset 03 eht fo tinu 1 taht erom

58 fo egnar eht edistuo 511 dna % eht fo % fo egnar eht edistuo tinu on dna mialc lebal

57 521 ot % lebal fo %roF .mialc 8.7 deecxe ton dluohs DSR lla %

[ ]7 . ytilibairF

hcae morf detceles erew stelbat )02( ytnewT stelbat fo puorg hcaE .dehgiew dna hctab 001( setunim 4 rof mpr 52 ta detator erew stelbat ehT .rotalibairf telbat eht ni )snoitator

dna tsud lliw neht erew er - ot dehgiew saw ytilibairF .thgiew ni ssol eht enimreted

ssol thgiew tnecrep sa detaluclac neht nwohsmorf ni stelbat lanigiro eht ]6[ .

nI - emit noitargetnisiD ortiv : fo sebut xis eht fo hcae ni decalp saw telbat A

etaw ni ylbmessa eht dnepsuS .teksab eht r c02 ± c073 fo erutarepmet a ta deniatniam ylsuoenatlumis ,sutarappa eht etarepo dna

etargetnisid ot nekat nekat emit eht eton pots gnisu yb yletelpmoc [ hctaw ]7 .

nI - :eliforp esaeler gurD ortiv ehT ni - ortiv demrofrep erew tset esaeler gurdSU yb t elddap P 51 ta sutarappa II epy mpr 0

sa 4.7 Hp reffub etahpsohp fo lm 009 gnisuam muidem noitulossid a ta deniatni

73 fo erutarepmet 0 5.0 ± C 0 detangised tA .C nwardhtiw erew selpmas lm 1 slavretni emit noitulossid hserf fo lm1 htiw decalper dna

niatniam ot muidem ehT .noitidnoc knis dezylana dna ylbatius detulid erew selpmas

yllacirtemotohportceps 032 ta mn . RITF seiduts :

arfnI mrofsnarT reiruoF - :ypocsortceps deR sremylop ,gurd erup fo seiduts ytilibitapmoC dna gurd fo erutxim lacisyhp eht dna

deirrac erew sremylop RITF gnisu tuoTF uzdamihS( retemotohportcepS - 0048 RI - )S

004 fo egnar gninnacs eht ni - mc0004 - yb 1dohtem csid rBK .

noitartnecnoc ecnabrosba mpp0 0 mpp2 600.0 mpp4 310.0 mpp6 910.0 mpp8 520.0

mpp01 230.0

Page 5: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 01

TLUSER :NOISSUCSID DNA S selbaT 2 tsil gnituo ,thgiew( seitreporp lacisyhp eht

cisahpib fo )ytilibairf dna ssendrah ,ssenkcihtmetsys .

elbaT :2 eniparivan fo gurd cisahpib eht fo seitreporp lacisyhP

on.s noitalumroF

*edoc thgieW

*)gm(noitairav mc/gk(ssendraH 2 *) *ytilibairF

)%(

*ssenkcihT )mm(

gurDtnetnoc

)%( 1 1F 94.51±00.045 01.0±08.4 50.0±6779.0 50.0±069.4 58 2 2F 19.81±28.825 50.0±37.4 50.0±3388.0 01.0±001.5 59 3 3F 10.71±17.5035 01.0±8.4 010.0±0048.0 50.0±332.5 .201 4 4F 01.91±58.206 51.0±61.5 500.0±6651.0 01.0±002.5 .101 5 5F 97.51±578.095 11.0±09.4 510.0±3373.0 50.0±633.5 501 6 6F 73.31±41.785 01.0±01.5 010.0±0061.0 50.0±638.5 99

)naem 3 fo gvA =*(

:sisylana RITF TF - snoitcaretni etaulave ot enod saw RI

rof artceps RI .remylop dna gurd eht neewteb ,esolullec lyhte ,CMPH sremylop ,gurd erup

gurd fo erutxim lacisyhp dna mug nahtnaX eht ni nwohs erew yllaudividni sremylop dna

1.serugif

erugiF 1:

)1 fo RITF eniparivaN gurd erup

)2 F RIT fo lacisyhp CMPH htiw eniparivaN fo erutxim

)3 esolullec lyhte htiw eniparivaN fo erutxim lacisyhp fo RITF

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 01

TLUSER :NOISSUCSID DNA S selbaT 2 tsil gnituo ,thgiew( seitreporp lacisyhp eht

cisahpib fo )ytilibairf dna ssendrah ,ssenkcihtmetsys .

elbaT :2 eniparivan fo gurd cisahpib eht fo seitreporp lacisyhP

on.s noitalumroF

*edoc thgieW

*)gm(noitairav mc/gk(ssendraH 2 *) *ytilibairF

)%(

*ssenkcihT )mm(

gurDtnetnoc

)%( 1 1F 94.51±00.045 01.0±08.4 50.0±6779.0 50.0±069.4 58 2 2F 19.81±28.825 50.0±37.4 50.0±3388.0 01.0±001.5 59 3 3F 10.71±17.5035 01.0±8.4 010.0±0048.0 50.0±332.5 .201 4 4F 01.91±58.206 51.0±61.5 500.0±6651.0 01.0±002.5 .101 5 5F 97.51±578.095 11.0±09.4 510.0±3373.0 50.0±633.5 501 6 6F 73.31±41.785 01.0±01.5 010.0±0061.0 50.0±638.5 99

)naem 3 fo gvA =*(

:sisylana RITF TF - snoitcaretni etaulave ot enod saw RI

rof artceps RI .remylop dna gurd eht neewteb ,esolullec lyhte ,CMPH sremylop ,gurd erup

gurd fo erutxim lacisyhp dna mug nahtnaX eht ni nwohs erew yllaudividni sremylop dna

1.serugif

erugiF 1:

)1 fo RITF eniparivaN gurd erup

)2 F RIT fo lacisyhp CMPH htiw eniparivaN fo erutxim

)3 esolullec lyhte htiw eniparivaN fo erutxim lacisyhp fo RITF

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 01

TLUSER :NOISSUCSID DNA S selbaT 2 tsil gnituo ,thgiew( seitreporp lacisyhp eht

cisahpib fo )ytilibairf dna ssendrah ,ssenkcihtmetsys .

elbaT :2 eniparivan fo gurd cisahpib eht fo seitreporp lacisyhP

on.s noitalumroF

*edoc thgieW

*)gm(noitairav mc/gk(ssendraH 2 *) *ytilibairF

)%(

*ssenkcihT )mm(

gurDtnetnoc

)%( 1 1F 94.51±00.045 01.0±08.4 50.0±6779.0 50.0±069.4 58 2 2F 19.81±28.825 50.0±37.4 50.0±3388.0 01.0±001.5 59 3 3F 10.71±17.5035 01.0±8.4 010.0±0048.0 50.0±332.5 .201 4 4F 01.91±58.206 51.0±61.5 500.0±6651.0 01.0±002.5 .101 5 5F 97.51±578.095 11.0±09.4 510.0±3373.0 50.0±633.5 501 6 6F 73.31±41.785 01.0±01.5 010.0±0061.0 50.0±638.5 99

)naem 3 fo gvA =*(

:sisylana RITF TF - snoitcaretni etaulave ot enod saw RI

rof artceps RI .remylop dna gurd eht neewteb ,esolullec lyhte ,CMPH sremylop ,gurd erup

gurd fo erutxim lacisyhp dna mug nahtnaX eht ni nwohs erew yllaudividni sremylop dna

1.serugif

erugiF 1:

)1 fo RITF eniparivaN gurd erup

)2 F RIT fo lacisyhp CMPH htiw eniparivaN fo erutxim

)3 esolullec lyhte htiw eniparivaN fo erutxim lacisyhp fo RITF

Page 6: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 11

lacisyhp fo RITF )4 fo erutxim mug nahtnaX htiw eniparivaN .

NI - ORTIV YDUTS NOITULOSSID :

ehT ni - ortiv eniparivan fo eliforp noitulossid desylana erew stelbat eroc desserpmoc morf ehT .mn 032 ta 4.7 Hp reffub etahpsohp ni

stelbat eroc desserpmoc eht fo eliforp esaeler lyhte ,CMPH gnisu deraperp eniparivan fo

nwohs erew mug nahtnaX dna esolullec ni( 2 erugif , erugif 3 erugif , 4)

giF . 2 : fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC nrettap esaeler etaidemmi ylnO

giF . 3: fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC ylno nrettap esaeler deniatsus

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 11

lacisyhp fo RITF )4 fo erutxim mug nahtnaX htiw eniparivaN .

NI - ORTIV YDUTS NOITULOSSID :

ehT ni - ortiv eniparivan fo eliforp noitulossid desylana erew stelbat eroc desserpmoc morf ehT .mn 032 ta 4.7 Hp reffub etahpsohp ni

stelbat eroc desserpmoc eht fo eliforp esaeler lyhte ,CMPH gnisu deraperp eniparivan fo

nwohs erew mug nahtnaX dna esolullec ni( 2 erugif , erugif 3 erugif , 4)

giF . 2 : fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC nrettap esaeler etaidemmi ylnO

giF . 3: fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC ylno nrettap esaeler deniatsus

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 11

lacisyhp fo RITF )4 fo erutxim mug nahtnaX htiw eniparivaN .

NI - ORTIV YDUTS NOITULOSSID :

ehT ni - ortiv eniparivan fo eliforp noitulossid desylana erew stelbat eroc desserpmoc morf ehT .mn 032 ta 4.7 Hp reffub etahpsohp ni

stelbat eroc desserpmoc eht fo eliforp esaeler lyhte ,CMPH gnisu deraperp eniparivan fo

nwohs erew mug nahtnaX dna esolullec ni( 2 erugif , erugif 3 erugif , 4)

giF . 2 : fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC nrettap esaeler etaidemmi ylnO

giF . 3: fo sehctab 6F ot 1F fo eliforp noitulossid evitarapmoC ylno nrettap esaeler deniatsus

Page 7: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 21

:4 giF nI - ortiv snoitalumrof suoirav fo metsys yreviled tnenopmoc laud fo noitulossid 1F( - )6F

NOISSUCSID esaeler deniatsus dna esaeler etaidemmi htoB

deraperp era noitalumrof gurd rieht dna ,3 gif ,2 gif ni nwohs neeb sah nrettap esaeler

(F gi 4) dna .mrof egasod elgnis a ni niatnoc htob fo noitalumrof eht sebircsed yduts ehT rof gurd esaeler dednetxe dna etaidemmi tneitap dna ycaciffe cituepareht desaercni

ecneinevnoc . tnoc oT degnolorp eht ni ,esaeler gurd eht lor

,metsys cisahpib eht fo tnenopmoc esaeler erew CMPH dna mug nahtnaX esolullec lyhte eroc eht ni stnega esaeler deniatsus sa desu eht ,smetsys yreviled gurd xirtam nI .telbat

xirtam eht fo scitsiretcarahc - tnega gnimrof esaeler eht ni elor tnatropmi na yalp eht gnomA .gurd eht fo smsinahcem eht fo eno si CMPH ,sremylop cilihpordyh eht rof desu ylnommoc tsom sreirrac yreviled gurd dellortnoc laro fo noitaraperp nopu llews ot ytiliba sti fo esuaceb smetsys

no noitacifilleg ehT .retaw htiw tcatnoc ni ec a sa gnitca ,reyal suocsiv a semoceb leg

retaw fo xulfni eht htob ot reirrab evitcetorpnoitulos ni gurd eht fo xulffe eht dna 8- nO .9

lyhte sa hcus sremylop treni ,dnah rehto eht eht ot sevitanretla sa evres nac esolullec

ews ,secirtam treni gnimrof yb sremylop gnill ta elbats ,noitca lacigoloisyhp on htiw taht slevel erutsiom dna seulav Hp tnereffid eht drawot gurd eht fo noisuffid eht lortnoc

.esaeler ot roirp xirtam eht fo ecafrus esaeler etaidemmi eht fo noitisopmoc ehT

moc yldipar dna drah a edivorp dluohs tnenop noisserpmoc wol ta telbat gnitargetnisid telbat eroc eht fo noitcapmoc eht dna secrof esaeler ro ytirgetni eht tceffa ton dluohs

roivaheb ehT .tnenopmoc esaeler wols eht fo snoitalumrof morf esaeler gurd egatnecrep 1F

5.68 saw 2F dna 54.98 dna % fo dne eht ta %21 3F morf esaeler gurd egatnecrep ehT .rh

54.48 dna %88.88 saw 4F dna fo dne eht ta % dna 5F morf esaeler gurd egatnecrep dna rh9

85.38 saw 6F 51.78 dna % fo dne eht ta % eb nac ti noitavresbo evoba eht morF .rh41 remylop fo noitartnecnoc eht sa taht deton

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 21

:4 giF nI - ortiv snoitalumrof suoirav fo metsys yreviled tnenopmoc laud fo noitulossid 1F( - )6F

NOISSUCSID esaeler deniatsus dna esaeler etaidemmi htoB

deraperp era noitalumrof gurd rieht dna ,3 gif ,2 gif ni nwohs neeb sah nrettap esaeler

(F gi 4) dna .mrof egasod elgnis a ni niatnoc htob fo noitalumrof eht sebircsed yduts ehT rof gurd esaeler dednetxe dna etaidemmi tneitap dna ycaciffe cituepareht desaercni

ecneinevnoc . tnoc oT degnolorp eht ni ,esaeler gurd eht lor

,metsys cisahpib eht fo tnenopmoc esaeler erew CMPH dna mug nahtnaX esolullec lyhte eroc eht ni stnega esaeler deniatsus sa desu eht ,smetsys yreviled gurd xirtam nI .telbat

xirtam eht fo scitsiretcarahc - tnega gnimrof esaeler eht ni elor tnatropmi na yalp eht gnomA .gurd eht fo smsinahcem eht fo eno si CMPH ,sremylop cilihpordyh eht rof desu ylnommoc tsom sreirrac yreviled gurd dellortnoc laro fo noitaraperp nopu llews ot ytiliba sti fo esuaceb smetsys

no noitacifilleg ehT .retaw htiw tcatnoc ni ec a sa gnitca ,reyal suocsiv a semoceb leg

retaw fo xulfni eht htob ot reirrab evitcetorpnoitulos ni gurd eht fo xulffe eht dna 8- nO .9

lyhte sa hcus sremylop treni ,dnah rehto eht eht ot sevitanretla sa evres nac esolullec

ews ,secirtam treni gnimrof yb sremylop gnill ta elbats ,noitca lacigoloisyhp on htiw taht slevel erutsiom dna seulav Hp tnereffid eht drawot gurd eht fo noisuffid eht lortnoc

.esaeler ot roirp xirtam eht fo ecafrus esaeler etaidemmi eht fo noitisopmoc ehT

moc yldipar dna drah a edivorp dluohs tnenop noisserpmoc wol ta telbat gnitargetnisid telbat eroc eht fo noitcapmoc eht dna secrof esaeler ro ytirgetni eht tceffa ton dluohs

roivaheb ehT .tnenopmoc esaeler wols eht fo snoitalumrof morf esaeler gurd egatnecrep 1F

5.68 saw 2F dna 54.98 dna % fo dne eht ta %21 3F morf esaeler gurd egatnecrep ehT .rh

54.48 dna %88.88 saw 4F dna fo dne eht ta % dna 5F morf esaeler gurd egatnecrep dna rh9

85.38 saw 6F 51.78 dna % fo dne eht ta % eb nac ti noitavresbo evoba eht morF .rh41 remylop fo noitartnecnoc eht sa taht deton

,weiveR & hcraeseR amrahP fo lanruoJ lanoitanretnI ceD (1 ;2102 8 :) 6- 31

adamahT hseraN )8(1 ;2102 RRPJI ,la.te 21

:4 giF nI - ortiv snoitalumrof suoirav fo metsys yreviled tnenopmoc laud fo noitulossid 1F( - )6F

NOISSUCSID esaeler deniatsus dna esaeler etaidemmi htoB

deraperp era noitalumrof gurd rieht dna ,3 gif ,2 gif ni nwohs neeb sah nrettap esaeler

(F gi 4) dna .mrof egasod elgnis a ni niatnoc htob fo noitalumrof eht sebircsed yduts ehT rof gurd esaeler dednetxe dna etaidemmi tneitap dna ycaciffe cituepareht desaercni

ecneinevnoc . tnoc oT degnolorp eht ni ,esaeler gurd eht lor

,metsys cisahpib eht fo tnenopmoc esaeler erew CMPH dna mug nahtnaX esolullec lyhte eroc eht ni stnega esaeler deniatsus sa desu eht ,smetsys yreviled gurd xirtam nI .telbat

xirtam eht fo scitsiretcarahc - tnega gnimrof esaeler eht ni elor tnatropmi na yalp eht gnomA .gurd eht fo smsinahcem eht fo eno si CMPH ,sremylop cilihpordyh eht rof desu ylnommoc tsom sreirrac yreviled gurd dellortnoc laro fo noitaraperp nopu llews ot ytiliba sti fo esuaceb smetsys

no noitacifilleg ehT .retaw htiw tcatnoc ni ec a sa gnitca ,reyal suocsiv a semoceb leg

retaw fo xulfni eht htob ot reirrab evitcetorpnoitulos ni gurd eht fo xulffe eht dna 8- nO .9

lyhte sa hcus sremylop treni ,dnah rehto eht eht ot sevitanretla sa evres nac esolullec

ews ,secirtam treni gnimrof yb sremylop gnill ta elbats ,noitca lacigoloisyhp on htiw taht slevel erutsiom dna seulav Hp tnereffid eht drawot gurd eht fo noisuffid eht lortnoc

.esaeler ot roirp xirtam eht fo ecafrus esaeler etaidemmi eht fo noitisopmoc ehT

moc yldipar dna drah a edivorp dluohs tnenop noisserpmoc wol ta telbat gnitargetnisid telbat eroc eht fo noitcapmoc eht dna secrof esaeler ro ytirgetni eht tceffa ton dluohs

roivaheb ehT .tnenopmoc esaeler wols eht fo snoitalumrof morf esaeler gurd egatnecrep 1F

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85.38 saw 6F 51.78 dna % fo dne eht ta % eb nac ti noitavresbo evoba eht morF .rh41 remylop fo noitartnecnoc eht sa taht deton

Page 8: International Journal of Pharma Research & Review, Dec 20 ...€¦ · International Journal of Pharma Research & Review, Dec 20 1 2; 1 (8):6-13 Nar esh Th a ma da et.a l , IJPRR 2012;

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O LANRUOJ LANOITANRETNI GURD FSER LABREH DNA YREVOCSID HCRAE

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841 – 061 .


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