International InterX Conference my presentationinterxclinic.com/wp-content/uploads/2016/11/B.-Dr-Zulia-Frost... · 01/11/2016 InterX Clinic© not for sale or re-distribution, only

01/11/2016

InterX Clinic© not for sale or re-distribution,

only for educational purposes 1

By Dr Zulia Frost

Credits to Dr Cori Carter, Paul Magee

First International InterX

Therapy conference

12 years anniversary

1

Historical reference

Russian technology

NRG

Family of InterX: Products & Users

Research & Studies

News

01/11/2016



From Russia With Inter-X

Credit to Dr Nigam presentation

• Interactive Neurostimulation

• Non-drug, non-surgical solution to reduce pain resulting from

a broad range of complex chronic and acute pain conditions

InterX Products

01/11/2016



Who is using InterX• MEDICAL:

– Carmarthenshire Trust Pain departments UK

– Colchester General UK

– London Bridge UK

– Physiotherapy Corporation (700 clinics) USA

– American Sports Medicine Institute USA

– The Mayo Clinics, Scripps Clinics, Duke Medical Centre USA

– AA (American Airlines)

• SPORT: – Rugby (RFU) UK, all clubs

– NFL (American Football)

– NBA (Basketball)

– MLS (Soccer)

– MLB (Baseball)

– Olympic teams Europe, USA, Canada

– Maria Sharapova tennis player

– Italian Soccer (AC Milan)

– Australian Institute of Sport (AIS)

– Australian SAS (Special forces)

– American Sports Medicine Institute

5

• MILITARY:

• US Army, Marines, Airforce

• Belvoir Military Hospital USA

• Walter Reed Hospital USA

• Landstuhl Military Hospital,

Germany

• Navy Seals, CA USA

• Andrews Military Hospital

(Annex and the Pentagon)

• Bethesda Military Hospital

USA

• West Point Military

Academy USA

Why Advanced Neurostimulaiton?

Technology

1. Interactive waveform changes in response to

impedance change

2. No gel used

3. High Voltage/Current Density

4. Electrode placement

Application

1. SCAN to find optimal low impedance points

2. TARGET to focus

3. Treat DYNAMICALY

4. Protocols based on Neurological distribution,

Reflex Projections and Acupuncture points

01/11/2016



How does it work?

Cellular mechanisms

Neurological model

Energetic model

Pain Relief Mechanisms

� Cellular

� Optimisation of energy metabolism

� Increased microcirculation

� Cytokines release

� Neurological

� Activation of Central Neural System (CNS) response (AC) through

� Aδ - Aβ Stimulation

� Inhibition of Dorsal Horn Neurons: Segmental Inhibition

� Hypothalamic-Pituitary-Adrenal-Axis activation- Autonomic Modulation

� Humoral response: Descending Inhibition by Release of Endogenous

Opioids & Regulative Peptides

�Extracellular matrix�Activation of meridian network, microcurrent (DC)

01/11/2016



Cellular changes

ATP cellular production

Microcirculation

Ca2+ Ionic concentration

How cell gets sick• Cell is a unit within whole organism, trillions of cells in the body constantly

communicating & processing information

• Energy is fundamental need for the cell

• Aerobic and anaerobic functioning

• Trauma & disease leads to anaerobic glycolysis, cellular respiration becomes damaged

Not enough ENERGY!

(only 2 ATP)

No Water!

Acidity

01/11/2016



High concentration of Ca2+

Ischemia

TRAUMA

Hypoxia + Acidosis

Local Nerve Growth Factor

in sympathetic ganglia

Norepinephrine

Constriction of vessels

Substance-P

decreased

perfusion and

energy production

hypovolemia

hypoproteinemia

hypovolemia

hypoproteinemia

Local spreading

down sympathetic

chain

Anaerobic Respiration

Reduced

ATP

Reduced

ATP

Local inflammation

affects neighbouring

cells

DISEASE

Local

oedema

Local

oedema

Dr Ivor S. Smith ‘A Unified Concept ‘

Alteration of Sol’/ Gel state of the cytoplasm

• two states of cytoplasm:

‘Sol’ – liquid state of cytoplasm (when Ca2+ is back to depot) energy demanding

‘Gel’ – more solid state of cytoplasm when Ca2+ and proteins are bound with water

Charged ions alter the state of cytoplasm and help conducting impulses via nerves

Communication between neurotransmitters in the synaptic gap can only be happening at Sol state

De-synchronisation or excessive Ca2+ release can disable normal cellular communication, causing numerous pathological states

www.quantumconsciousness.org

01/11/2016



SUPPORTING STUDIES

ATP and CYTOKINS enhanced production

Return to Aerobic Cellular respiration

• Restoring Energy

processes in the

cell – ATP

• Regulation of

intracellular Ca2+

• Repair acidosis and

Hypoxia

University of Cincinnati Blood Study, INTERACTIVE NEUROSTIMULATION ELICITS SIGNIFICANTLY GREATER PHYSIOLOGICAL RESPONSE THAN TENS: LYMPHOCYTE METABOLISM AND

CYTOKINE PRODUCTION Joseph F.Clark, ATC, PhD. Gail Pyne-Geithman, D Phil, Paul J Magee Department of Neurology, University of Cincinnati, OH 45267-0536, USA

01/11/2016



Neurological Model

�Activation of Central Neural System (CNS) response (AC) through

�Aδ - Aβ Stimulation

�Inhibition of Dorsal Horn Neurons: Segmental Inhibition

�Hypothalamic-Pituitary-Adrenal-Axis activation- Autonomic Modulation

�Humoral response: Descending Inhibition by

�Release of Endogenous Opioids & Regulative Peptides

Neurostimulation with InterX

An introduction to pain pathways and mechanisms. Dr Danielle Reddi London, Dr Natasha Curran UCLH, Dr, Robert Stephens, UCLH

• The InterX™ is a neurostimulator

• Stimulation is only limited and

targeted to the skin

• Cutaneous receptors are primary

Aδ, Aβ. C are mainly internal organs

• Aδ - pain and itch & temperature

• Aβ - touch, pressure, vibration

01/11/2016



Neurostimulation

• Cutaneous receptors process pain signals

(nociceptors C and Aδ fibres) and A sufficiently

high intensity of stimulation can affect – Aδ, Aβ

• Treating at higher intensities has been shown to

cause greater inhibition and therefore pain relief

• Inhibition of ascending pain messages

Kevin J.Tracey. “Electric cures. Shock Medicine. Stimulation of the nervous system could

replace drugs for inflammatory and autoimmune conditions” Scientific American, March

2015, 28- 32 Lee KH, Chung JM, Willis WD, Inhibition of primate spinothalamic tract cells by

TENS, Journ Neurosurg, 62: pp276-287, 1985

Afferent neurons, through a series of synapses

sensory transduction to CNS - Spinal

cord/Thalamus/Hypothalamus/Somatosensoric

cortex

• Local zones: Segmental inhibition• Neurostimulation activates spinal neurons

to of release of endorphins (Encephalin, Dynorphin to inhibit pain messages

• Activation of spinal cord neurons, spino-thanlamic/ spino-reticular pathways aids natural descending inhibition of pain by release of β-endorphins, activation of HPA-axis to release ACTH to activate adrenal and immune responses, leading to reduction of inflammation

• General zones: Midbrain activates Peri Aqueductal Grey (PAG) & Rostral Ventromedial Medulla (RVM) with high concentrations of opioids, and project to dorsal horn to inhibit pain transmission. These pathways use noradrenaline and serotonin

InterX - Pain control mechanisms

01/11/2016



Body Systemic Response

• NIN is effective to treat pain;

• here is a diagram represents

non-linear relationship in the

neuro-humoral response to

NIN stimulation

• Disruption of homeostasis by

injury activates programs of

neural, hormonal and

behavioural activity aimed at

a return of homeostasis

Physiol Rev 86: 1309–1379, 2006 doi:10.1152/physrev.00026.2005;.

SUPPORTING STUDIES

ENDORPHINS & ACTH release

HPA axis activation CNS, brain hypo-arousal EEG study

(new)

01/11/2016



InterX versus TENS

Cytokine Changes

University of Cincinnati Blood Study, INTERACTIVE NEUROSTIMULATION ELICITS SIGNIFICANTLY GREATER PHYSIOLOGICAL RESPONSE THAN TENS:

LYMPHOCYTE METABOLISM AND CYTOKINE PRODUCTION

Joseph F.Clark, ATC, PhD. Gail Pyne-Geithman, D Phil, Paul J Magee Department of Neurology, University of Cincinnati, OH 45267-0536, USA

InterX versus TENSEffects on neuropeptides

preliminary data

0

100

200

300

400

500

600

TENS InterX

% change in ACTH

TENS

InterX

4X more

effect Than

TENS

Presented as a poster at the 13th World Congress on Pain, Montreal. Aug 29th - Sept. 2nd, 2010. PW 253

01/11/2016



-80

-70

-60

-50

-40

-30

-20

-10

0

TENS InterX

% Change in Met-enkephalin

TENS

InterX

-80

-70

-60

-50

-40

-30

-20

-10

0

TENS InterX

% Change in Leu-enkephalin

1.8 X more effect than TENS

InterX versus TENSEffects on neuropeptides

preliminary data



0

20

40

60

80

100

120

140

160

180

TENS InterX

% Change in Dynorphin

TENS

InterX

6 X more effect than TENS

InterX versus TENS

Effects on neuropeptidespreliminary data


0

20

40

60

80

100

120

140

TENS InterX

% Change in β-Endorphin

TENS

InterX


01/11/2016



Case study using EEG- Neurofeedback Pre, During

and Post InterX Therapy (pre-publication)

Dr Lesley Parkinson

• Male age 66 years, January 2009 partial left nephrectomy, radical right nephrectomy. No other medical history of note. Developed weakness, atrophy and discomfort in gluteal muscles and left thigh, reduced ease of walking, stiffness. Poor stability. Previously highly athletic.

• Physiotherapy, osteotherapy, sports massage, all to no significant effect

• Six InterX therapy sessions in total, 4 sessions on weekly basis at the clinic, followed by a home treatment using the Personal InterX every other day from session 5, to session 6 (2 weeks), with the final assessment

• A significant improvement in stability, muscular tone and no discomfort or stiffness

Understanding EEG wavebands:

• The DELTA waveband has two key relevant measures for this study, it is an indicator of arousal level in the brain and the higher the amplitude value the more HYPO aroused the brain. It is the main sleep wave. However, it can also act as a carrier wave so that when the brain/CNS is healing delta will rise to facilitate the healthier levels of the medium range brainwaves and it also acts as a ‘brake’ on the HI BETA stress wave.

• Hyperarousal of the nervous system is really another name for the stress response also known as “fight or flight.”

• The ALFA waveband is associated with optimum CNS control and the Americans sometimes refer to this waveband as the ‘conductor of the CNS symphony’. The alpha wave is the only waveband that is also measured below the brainstem in the spinal column.

• The LO BETA brainwave is associated with optimal health functioning.

• The HI BETA waveband is generally seen as an index of stress in the CNS.

• The GAMMA waveband is sometimes referred to as a binding rhythm and is an index as to how hard the brain is having to work to achieve control.

01/11/2016



Results, waveband change throughout treatment

course

D D D D D D D DA A A A A A A ALB LB LB LB LB LB LB LBHB HB HB HB HB HB HB HBG G G G G G G G0

10

20

30

40

50

60

1 2 3 4 5 6 7 8

Am

pli

tud

e (

Hz)

Sessions

Pre Post Pre Post

Session 4Pre Post

Session 5

Pre Post

Session 6

• Overall it can be seen that in terms of pre-post treatment measures there was a significant reduction in all brainwave amplitudes and it should be noted that ‘an efficient brain is a quiet brain’

Base line & first session

01/11/2016



Mid Sensory Motor Strip (SMS) Spectral Array

• Pre and Post InterX Session 2• Base line: Pre InterX Session 1

• Base line –

hyperarousal of CNS

• After the 1st session

• Calming effect on CNS

Mid Sensory Motor Strip (SMS) Spectral Array

01/11/2016



Summary

• NIN – Interactive Neurostimulation Therapy has

positive calming effect of Hypo-arousal on CNS

• NIN has a sustained result

• Carries on with home training protocol

• Effective on pain, stress reduction and insomnia

EXTRACELLULLAR NETWORK

Activation of Meridian network

01/11/2016



Duality of neuro-signalling system

�Neural – consists of central and

peripheral neural system

� Living matrix – ‘perineural’ system

� It is most ancient controlling

system in the body

33

‘Energy Medicine’ Oschman, 2000

• A reticular system of pathways in which Qi and blood circulate throughout the body

• Consists of 12 meridians, 8 extra meridians, branch collaterals, superficial and minute collaterals

Meridians

34

01/11/2016



Living matrix

Consists of collagen-rich extracellular connective tissues

and extends throughout skin, endothelium, periost, fascia,

ligaments, tendons, organ’s capsules, Schwan and glial

cells as well as cytoskeletal matrices within the cells an

nuclei (Pienta and Coffrey 1991)

35

InterX Stimulation

– High density

– high voltage

– variable

– DC/AC

– up to 10 kHz in one pulse

– interactive

– groups in 15 to 480PPS

36

– Activation of Cellular ATP

– Passing electrical energy via

meridians (DC)

– Stimulation of neural network

(AC)

– Enabling self-regulation

01/11/2016



Meridians are bio-energy pathways

• Meridians are part of ‘living matrix’, which is an extra-cellular network that extends further into each cell (cytoskeleton) (Oschman

1993;2000;2003)

• Physical properties of meridian system are crystalline, piezoelectric semi-conductive

• Acupuncture system is an extremely high speed communication network, with signal velocities hundreds of times faster than nervous conduction (Jones 2004)

• Together with living matrix and polarised water crystals the meridians act like a superconducting medium to convey any type of energy: Electrical, Electromagnetic – light, Sound energy

• Meridians are integral to the neural system in the body, facilitating energy delivery in the body (Dr Shui Yin Lo 2004)

• https://youtu.be/tYdX5IP7lOE?start=140&end=371

CASE STUDIES

01/11/2016



Acute Rugby Injury

• Wasps and England Rugby Player, 21yrs old

• Tackle from side/behind; Tackling player’s hip/bodyweight landed on everted ankle of tackled

player

• Double fracture and dislocation of ankle

• Required immediate surgery

• InterX implemented immediately to reduce pain and inflammation, ‘1-2 InterX treatments daily

• Manual therapy and intensive Rehab

• Returned to full competitive play: 18 weeks (6-8 weeks faster than expected)

Danny Cipriani

Oct. 2nd 2008May 18th 2008With permission from InterX technologies©.

Acute and Chronic Knee Pain

• Acute injury to both knees with bruising with oedema, where the chronic

arthritic knee pain is present on the left knee

• Both resolved within 4 weekly sessions and two week supported by home

use device. No pain or restriction in movement after 3rd session.

• Unfortunately, the left knee got re-injured two days prior the second photo

was taken

01/11/2016



Full Achilles' Tear

• InterX therapy started immediately, from the point of injury

• 3 times a day 30 minutes for first three weeks, then once a day

• Painkillers only first day, then no pain

• Oedema and bruising cleared within first two weeks, started to put pressure

week four

• Walking without a boot week 8

• Driving, week 11

Disc hernia - neck

Full pain relief and function within 3

weeks

01/11/2016



Foot bruising

10 minutes from injury3 hours from injury – no pain throughout recovery

3 hours later

Severe Foot Bruising

Moment of injury

1 hour from injury

01/11/2016



Shoulder Fracture

• X-Ray after exactly three weeks from the day of trauma confirmed a

complete healing

23 March 2010

16 April 2010

Testimonials• On Monday 10th Feb. '14 I was in agony... The treatment helped

enormously… I crawled up her stairs to her treatment room on my hands and knees...an hour later I was able to walk back down them...

• I have had two major Stenosis operations in my life on the lower back from L1 to L5 with a partial cutting back of S1. I suffered severe back pain every day. I simply couldn't get out of bed in the morning without heavy pain killing medication, I'm talking about Oramorph and up to 8 Co-Dydramol a day! This was before I started InterX treatment.

• Now I take virtually no pain killers... Under Zulia's recommendations and guidance I have found InterX to be a bit of a "cure all" apart from my back treatment I have found pain relief with InterX from stiff necks, bumps and bruises, knee pain, and even insect bites.. It is a remarkable invention. I couldn't be without mine.

• Signed Tim Harrison...A very happy customer.

01/11/2016



Testimonials

• I had chronic Achilles tendinopathy for a number of years. I tried NHS and private treatments including physiotherapy, exercises, podiatry, orthotics, saline injections, shockwave therapy [very painful], osteopathy and a surgical boot. None of it worked and the condition was not only sore but was also limiting my lifestyle.

• My osteopath suggested I make an appointment with Zulia to try IntereX therapy which I did. Due to the severity of the condition it took a little longer than expected to repair but Zulia assured me categorically that it would recover and to my delight my tendon healed completely within a few months

and I can now walk normally.

• Diane G. severe chronic tendinopathy sufferer

Testimonials

• I used the personal InterX device under a guidance from Dr Zulia Frost. First off I have to say what an improvement there has been in the back pain from the condition! I think the nerves learn pain signals and forget to stop when the pain stops as this has settled right down now when it used to be a constant pain, literally every day.

• I also used it for my shoulder injuries and there has been a significant improvement in those again, so much that I have been able to exercise again and build up my strength in them which I have not been able to do for years because of the pain in those. I go Air Gunning and could not cock a springer air gun and have just bought my first springer air rifle so although not directly linked to the pancreatitis a real bonus in life!

• The back ache has been the best relief of all as this used to be constant and can even rive now without being in constant pain after just driving a few miles to my local park with my dog. Even managing to walk him short distances now as well.

• Jim A., chronic pancreatitis sufferer

01/11/2016



Testimonials• I have only had one episode of 'nerve pain' since I last saw you, and that

was due to having worn wellies when I walked the dogs. The damage to my MTP joints has not repaired and the ganglion is still present. I have to wear flat, well-cushioned footwear but I am able to drive a manual vehicle for a short distance. So, of the objectives I stated when I started my treatment with you, I think the only thing I haven't achieved is to be able to wear high heels. I can live with that restriction!

• The Interx is the best pain relief I know and I will be eternally grateful that I have it. My husband has had problems with kidney stones a couple of times and has found the Interx very helpful in dealing with the pain. And I lent the device to my brother-in-law when he injured his back a few months ago - he was very impressed with the speed with which he recovered.

• Thank you again for all you did for me - I am certain that I would not have recovered my mobility to this extent without your treatment.

• P. R. CPRS sufferer

InterX Changed My Life!

• Prior to my InterX treatments I had long term, chronic back pain. The pain was constant and life was a series of challenges as I struggled with sitting (or standing) for any length of time. My life was planned around my pain. This had been a continuous problem in my life for around 15 years. Having been through the usual channels in Scotland – injections, drugs, physiotherapy I then saw a chiropractor and various ‘alternative’ therapists. Some of which gave me temporary relief but no long term improvement.

• Then, following a move to England – the same again, culminating in a consultation with a Chronic Pain Management Consultant. Diagnosis? Wear & tear! The outcome? Painkillers and nerve pain inhibitors – along with the other drugs required to counteract side-effects. So I thought this was my future, and now aged 48 I could only see a (hopefully) long road ahead, taking all these pills with a painful problem which would surely only get worse.

• Then I found Dr Zulia Frost and InterX. I was drug free after my second treatment. I am now pain free and able to walk, sit and stand without careful forward planning! I recently danced all night at a wedding, something which would have been impossible six months ago. Truly amazing...

• Amanda M, chronic back pain sufferer

01/11/2016



Summary InterX in Clinic

• Safe and without side-effects

• Controlling pain energetically without drugs

• When used as soon as – heals very quickly

• Can be used after surgery or for wounds for

quicker results

• Synergetic effects with other therapies

Documents

International InterX Conference my presentationinterxclinic.com/wp-content/uploads/2016/11/B.-Dr-Zulia-Frost... · 01/11/2016 InterX Clinic© not for sale or re-distribution, only