INTEGRA MOZAIK VS.ZIMMER COPIOS

Osteobiologics Products

Cory Jensen

Integra Mozaik

• Product Name: Integra Mozaik• Approval Date: Jan. 19 2007

Integra Mozaik

• Approved for: The Integra MOZAIK Strip is intended for use as a bone void filler to fill voids or gaps of the skeletal system in the extremities, spine, and pelvis not intrinsic to the stability of the bony structure. Integra MOZAIK Strip is also indicated for use in the treatment of surgically treated osseous defects or osseous defects created from traumatic injury to the bone.

Integra Mozaik

• Chemical Composition: Calcium Salt with Type I Bovine Collagen

• Mineral Phase: Tricalcium Phosphate

• Osteocunductive Characteristic - TCP

Integra Mozaik

Handling Characteristics

Strip Putty Moldable Morsels

Strip – Maintains graft volume, and retains natural bioactive fluids wellPutty – Moldability is optimal for irregular shaped defect sitesMorsel – provides more compression resistance than the putty. Easily hydrated and bound together with other morsels.

Integra Mozaik

Where can surgeon apply product? • The Integra MOZAIK Strip is intended for use as a bone

void filler to fill voids or gaps of the skeletal system in the extremities, spine, and pelvis not intrinsic to the stability of the bony structure.

Integra Mozaik

Advantages

• Collagen Structure• Rapid Absorption or BMPs.• Exceptional Handling

• Allows for radiographic visualization of bone graft placement

• Overall 90% fusion rate (all levels)

Integra Mozaik

• Integra Mozaik Osteoconductive Scaffold has been shown to be equally effective to autograft

Integra Mozaik

Disadvantages• Only Osteoconductive• Besides strip, it is not similar to bone.• Lacking Strength compared to other Osteoconductive

products

Zimmer Copios

• Product Name• Zimmer Copios

• Approved• June 1 2007

Zimmer Copios

Approved for:

• CopiOsTm Bone Void Filler, in combination with autologous blood products such as bone marrow, is intended for use only for filling bone voids or gaps of the skeletal system (i.e. extremities, pelvis, spine) that are not intrinsic to the stability of the bone structure. These voids may be a result of trauma or creation by surgeon. Copios Bone Void Filler is intended to be gently packed into the void or gap and will resorb during the course of the healing process.

Zimmer Copios

Material• CopiOs Bone Void Filler Sponge is a synthetic bone graft

material consisting of mineralized, lyophilized collagen. CopiOs4 Bone Void Fillers are resorbable rectangular sponges or powder discs manufactured from calcium phosphate and Type I bovine dermal collagen.

Osteoconductive Property:• Calcium Phosphate

Zimmer Copios

Handling Characteristics• Soaks like a Sponge and is fairly malleable

Where Can Surgeon Apply?• CopiOsTm Bone Void Filler, in combination with autologous

blood products such as bone marrow, is intended for use only for filling bone voids or gaps of the skeletal system (i.e. extremities, pelvis, spine) that are not intrinsic to the stability of the bone structure.

Zimmer Copios

Clinically Proven Technology • In a prospective, randomized, multi-center study of

213 patients (249 long bone fractures) that compared autogenous iliac crest bone graft (ICBG) to calcium phosphate (CaP)-collagen graft (Collagraft® Matrix) the authors concluded that composite grafts of CaP-collagen material and bone marrow aspirate are as effective and as safe as autogenous bone graft in the treatment of fracture defects of long bones.

Zimmer Copios

Advantages:• An abundance of localized calcium and phosphate ions

promotes bone formation.• Acidic conditions for bone healing may preserve the

solubility of osteoinductive proteins for bone healing.• A high porosity collagen sponge scaffold or a high void

volume paste provides the 3-D structure, which plays a key osteoconductive role in bone regeneration.

• Resorption concurrent with bone growth. • Biocompatibility and safety. • Excellent handling and ease-of-use.

Zimmer Copios

• Advantages:• CopiOs Bone Void Filler provides a moderately acidic

environment that promotes solubility of osteoinductive growth factors such as bone morphogenic proteins (BMPs)

• More soluble BMPs may remain available for bone healing processes in the early stages of bone growth

Zimmer Copios

• Disadvantages• Osteoconductive only.• Only available in Strip and Paste• Strength compared to competitors

Comparison

If I were to choose between carrying the Integra Mozaik and Zimmer Copios, I would choose:

Integra Advantages

• Proven Results• Almost flawless fusion Success

Integra Advantages

Strip Putty Moldable Morsels

Great Advantage in being able to offer the Surgeon a product that can garner excellent results in a variety of forms.

Integra Advantages• The highly purified β-TCP along with cross-linked Type-I collagen in

Integra Mozaik strip provides the material with structure and compression resistance while maintaining the flexibility to conform to uneven surfaces.