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Innovation and US Manufacturing Competitiveness Tom Baruch Founder, CMEA Capital Innovators – SAMCEDA 2010 Awards of Excellence April 30, 2010. Venture Capital Investments by Region, 2009. Silicon Valley. PWC/NVCA MoneyTree Report. 1. Demise of Corporate Research. Bell Labs. - PowerPoint PPT Presentation
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Innovation and US Manufacturing CompetitivenessTom Baruch
Founder, CMEA Capital
Innovators – SAMCEDA 2010 Awards of ExcellenceApril 30, 2010
Venture Capital Investments by Region, 2009
PWC/NVCA MoneyTree Report
Silicon Valley
1
Demise of Corporate Research
Bell Labs
Pharma Patent Cliff:
revenue coming off patent by 2012
Datamonitor
$ B
illio
n
2
Moore’s Law Meets Mendel’s Law
For the past 50 years Moore’s Law has driven innovation in electronics and biotechnology
R.H. Carlson (2010) Biology is TechnologyHarvard University Press
Tra
ns
isto
rs p
er
Ch
ip;
Ba
ses
/pe
rso
n/d
ay
Year3
Young Firms Account for the Bulk of Job Creation
Share of annualized net job creation in 2007.
Per
cen
t
Firm Age
Kauffman Foundation, U.S. Census Bureau
4
Jo
bs
(in
mi ll
ion
s)
Job Creation by Startups
Kauffman Foundation, U.S. Census Bureau
5
VC’s as Brokers of Innovation
Large companies
Universities
Venture Capital
Startups
Mid-size Companies
6
Leadership
7
Innovation AgendaInnovation Agenda
• K-12 education in reading, science and math
• Basic research
• R&D tax credits
• Lower corporate taxes
• Intellectual Property Protection
• Ambassadors of entrepreneurship
• Immigration
8
Energy Market is >$2 Trillion
A $1 Trillion Opportunity in Renewables/Efficiency
Demand• BRIC Economies• Geopolitics• Energy Security
Supply
• “Exponential Technologies”• Low Carbon Economy• Depletion of Non-Renewables• Global Scramble• Barrel of Oil @ $60-80
9
Urgent New Applications in Climate Change and Energy
Tremendous Need for Low Carbon Technologies
Carbon Mitigation Initiative, Princeton University
10
Convergence and Innovation
The next 50 years will require collaborative, global and multi-disciplinary processes
Innovation will happen at the borders where different disciplines meet
Energy and Materials Life Science
Information Technology
11
Applications Development
A Major Opportunity - Closing the Scale-Up Financing Gap
Commercial Products
Materials Discovery
Bottlenecks in Commercializing New Technology
10 years 10 years
Accelerated Commercialization will occur at the intersection of problems and markets
20 years
Intimacy of problems and markets is key
12
Optimized Final Product
Assay the Library
Representative Predictive
Automated: uses computational analysis
Create Library
Biological or Material Automated High-throughput
Synthesis Introduces Complexity and
Novelty
Select Winners
Build new library based on best-performing materials
Platforms enable discovery of new materials >1000x faster than traditional methods
Accelerating Materials Discovery with Combi Synthesis
Market input Market input
13
A Major Opportunity - Closing the Scale-Up Financing Gap Semiconductor Industry Challenge
New materials drive IC performance more than reductions in scale
14
Intermolecular’s Solution
Massively Parallel Processing Enables Faster Cycles of Learning
Many Processes/Wafer
OneProcess/Wafer
Conventional R&D Approach
Combinatorial R&D Approach
15
A Major Opportunity - Closing the Scale-Up Financing Gap Intermolecular: Representative Project
Using Moore’s Law to Accelerate Moore’s Law
Molecular Masking Layer for 32nm Copper Interconnect
4 Engineers5 Weeks
7,635 experiments (deposition conditions) on 60 molecular types
18,300 characterization experiments
2 Hits for Scale-up
Using conventional methods and the same number of people:
• It would have taken 5 years instead of 5 weeks to run this number of experiments.
• Only 140 process conditions could have been analyzed, instead of 7600
16
A Major Opportunity - Closing the Scale-Up Financing Gap
ProSARAnalytics
Wild typeEnzyme
EvolvedCommercial Biocatalyst
Codexis Technology Platform
17
A Major Opportunity - Closing the Scale-Up Financing Gap Cellular Engineering
Cellular EngineeringCellular Engineering
Transcriptomics
Proteomics
Metabolomics
Fluxomics
Genomics
InputInput ProductProduct
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Innovation and Entrepreneurship will…Innovation and Entrepreneurship will…
• Leadership
Top to Bottom Commitment
• Platforms
Innovation Economy
Programs
• Policies
Market Intimacy
Experienced Entrepreneurs
Revitalize the Commercial and Economic Power of Silicon Valley
19