Inner-Cell-Mass Cell

Embryonic Stem Cells

Ectoderm Mesoderm Endoderm

Blastocyst

Forms PlacentaBecomes Baby

3 Primary Tissue Types

Primary Tissue Layers

Ectoderm

skinnerves

eyes

Mesoderm

bonesmuscles

blood

Endoderm

Lining of gut

lungs liver

There are over 200 cell types in the adult body

Mesenchymal Stem Cells

Muscle

Repair of cardiac tissue

Skin

Skin grafts after burn orReconstructive surgery

Fat Cells

Reconstruction Surgeries

Nerves

Repair of nerve damage

Tendons / Cartilage

Joint & Back Repair

Bone

Bone regrowth

Retinal PhotoreceptorsCorneal Repair

Regain sight after injury

Teeth

Repair or Replace Teeth

Liver

Liver Disease

Insulin secreting cells

Diabetes

Trachea & Lung

Trachea ReplacementLung Diseases

Blood Vessels

Tissue Repair and Regrowth

Mesenchymal Stem Cells

Potential of MSC’s from TeethWhat can these cells do functionally?

There are several papers which have shown the ability of the MSC’s from teeth both the lab and in animal to differentiate down these pathways.

SHED: stem cells from human exfoliated deciduous teeth.Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S.Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12.

Neurogenic Osteogenic Odontogenic Myogenic Chondrogenic

Adipogenesis or fat production

Differentiation Process