Informe Vía Grupo Funcional Metildopa

7/23/2019 Informe Va Grupo Funcional Metildopa

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GCDRDE6 PGQDZ6 Qe/ @e/ KZGZEP AGJHK BGGORPGMK6

08%;;%;0\mdok ; bg ::

AKJWIRKB BG GZRWBDEZ ZW\GPDEPGZ VKPKMEVK

CEBWIE6 BGZKPPEIIE KOKIDRJE\PETGJRE6 KOIDZDZ QK MPW\E AWOJDEOKI CGRDIBE\K RK@IGRKZ

OBDJG

D/ AWOBKCGORKJDO;/ KOIDZDZ QK MPW\E AWOJDEOKI/:

0/ GZ\GJRPEZJE\K WIRPKQDEIGRK#QDZD@IG/2

:/ IGT BG IKC@GPR#@GGP7

2/ GZ\GJRPEAERCGRPE WQ#QDZD@IG/1

7/ \PE\DGBKBGZ CGRDIBE\K/////////=

DD/ E@FGRDQE MGOGPKI//40/; E@FGRDQEZ GZ\GJADJEZ//4

DDD/ CKRGPDKI/4

DQ/ G[WD\EZ/;<

Q/ PGKJRDQEZ/;


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XQ/ KOGXEZ (JIJWIEZ$/01

XQD/ @D@IDEMPKAK //::


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D/ AWOBKCGORKJDO

;/ KOIDZDZ QK MPW\E AWOJDEOKIWo mpw|e awojdeoki gz wo rece e wo mpw|e bg recez {wg ckodadgzrk wokpgkjrdqdbkb {wcdjk jkpkjrgpzrdjk/ Rebkz ikz ceijwikz (bgorpe bg icdrgz `kzrkorgkc|idez$ jeordgogo wo bgrgpcdokbe mpw|e awojdeoki {wg gx|gpdcgork jdgprkzpgkjjdeogz/

Iez crebez bg mpw|ez awojdeokigz jeozrko bg bez |kprgz6 |pdcgpk) ik pgkjjdo{wcdjk e pgkjjdeogz k ikz {wg zg zecgrg gi jec|wgzre cwgzrpk) t gi zgmwobe) ikcgbdbk adoki (ik jeojiwzdo$) {wg zwgig zgp jwkordrkrdqk/ Kimwokz qgjgz gzrkz bez|kprgz zg gorpgcgvjiko jece go wok zdc|ig qkiepkjdo) |gpe |ep ie mgogpki zeo

e|gpkjdeogz bdzjpgrkz/

Go gi gzrwbde bg koidzdz bg mpw|ez awojdeokigz zg |kprg bg ik jeozdbgpkjdo bg ikpgkjjdo mgogpki6

Cwgzrpk . Pgkjrdqe \pebwjre K . \pebwjre @

Bez agocgoez mgogpkigz jeorpeiko ik wrdidbkb kokirdjk bg ik pgkjjdo/ Woe bggzrez gz gi gzrkbe bg g{wdid`pde) e ik kc|idrwb go {wg iez pgkjrkorgz aepcko|pebwjrez jwkobe zg kijkovk gi gzrkbe bg g{wdid`pde/ Ik jeozrkorg bg g{wdid`pde gzwok cgbdbk bg gzre t e`qdkcgorg gz bg bgzgkp {wg zw qkiep zgk kire/

Gi zgmwobe pkzme |pgbecdokorg gz ik qgiejdbkb bg pgkjjdo) {wg hk bg zgp iezwadjdgorgcgorg mpkobg |kpk rgogp iez pg{wgpdcdgorez bg qgiejdbkb kokirdjk/ Jk`gkirgpkp qkpdkz jeobdjdeogz (rgc|gpkrwpk) jkridzdz) zeiqgorg$ |kpk dojpgcgorkp ikqgiejdbkb bg pgkjjdo/

Zd ik pgkjjdo kokirdjk |ezgg ik qgiejdbkb zkrdzakjrepdk t |pe|dgbkbgz bg g{wdid`pde)|wgbg wzkpzg |kpk bgrgpcdokp ik cwgzrpk |ep kbdjdo bg wo gxjgze bg pgkjrdqe/Jec|igrkbk ik pgkjjdo (gz bgjdp) bgz|wz bg hk`gp jeozgmwdbe gi g{wdid`pde$ ikjeojiwzdo jwkordrkrdqk bgi koidzdz zg hkjg |ep6 (;$ bgrgpcdokjdo bg ik jkordbkb

bg pgkjrdqe {wg oe hk pgkjjdeokbe) {wg zg zwzrpkg bgi rerki bgi pgkjrdqe rerkikkbdbe |kpk e`rgogp ik jkordbkb bg ik cwgzrpk> (0$ bgrgpcdokjdo bg ik jkordbkbbg |pebwjre K> e (:$ bgrgpcdokjdo bg ik jkordbkb bg |pebwjre @/


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Gz |ezdìg {wg gzrkz cgbdbkz pg{wdgpko |ezrgpdepgz pgkjjdeogz/ Ik bgrgpcdokjdoadoki |wgbg hkjgpzg |ep crebez tk jeozdbgpkbez rkigz jece qeiwcgrpk)

gz|gjrpeaerecgrpk) pgapkjrecgrpk) |eikpdcgrpk) |eikpempkak) aiwepdcgrpk ebgrgjjdo jpeckrempadjk/

Kimwokz qgjgz gi koidzdz bg mpw|ez awojdeokigz epmodjez zg pgkidvk |ep crebezazdjez) gz bgjdp zdo {wg ejwppk wok pgkjjdo {wcdjk/ Go gzrg zgordbe iez crebezgz|gjrpeaerecrpdjez zeo bgrgjrepgz bg mpw|ez awojdeokigz/

Kwo{wg gzrk rjodjk oe |wgbg |pe|epjdeokp ik dbgordadjkjdo dog{wqejk bg wojec|wgzre epmodje gi gz|gjrpe bg k`zepjdo go ikz pgmdeogz wirpkqdeigrk t qdzdìggz rdi |kpk bgrgjrkp ik |pgzgojdk bg jdgprez mpw|ez awojdeokigz {wg kjrko jece

jpecaepez/0/ GZ\GJRPEZJE\K WIRPKQEIGRK#QDZD@IG

Zg awobkcgork go {wg ik ceijwik k bgrgpcdokp bg`g |pgzgorkp beìgz goikjgz e|kpgz bg gigjrpeogz id`pgz iez jwkigz zeo |peceqdbez bg wo gzrkbe `kzki k wogzrkbe gxjdrkbe k`zep`dgobe ik pkbdkjdo gigjrpeckmordjk t id`gpkobe gi gxjgzebg gogpmk go aepck bg jkiep/

Ik pgmdo bgi qdzdìg zg gxrdgobg bgzbg :7< k 8


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bg ik cxdck zgpk wo gagjre d|zejpcdje e wok bdzcdowjdo bg ik k`zep`kojdk(gagjre hd|ejpcdje$/

Ik gz|gjrpezje|k WQ#QDZ gz wok bg ikz hgppkcdgorkz cz rdigz jeo ikz {wgjwgork gi jdgoradje |kpk gi koidzdz jwkordrkrdqe tk {wg zg |wgbg bgrgpcdokp ikjeojgorpkjdo bg woe e qkpdez gigcgorez go iez gz|gjrpez t bgrgpcdokp gi pgk{wg ejw|ko jkbk woe bg iez cxdcez bg gzez gz|gjrpez) zdgobe |ep cgbde bggzrez |krpeogz ajdi ik bgrgpcdokjdo bg ik jeojgorpkjdo {wcdjk bg zwzjeozrdrwtgorgz/ Iez bkrez gz|gjrpkigz bg k`zepjdo go gi wirpkqdeigrk#qdzd`ig zgzwgigo |pgzgorkp jece mpadjkz bg k`zep`kojdk e iemkpdrce bgi jegadjdgorg bggxrdojdo apgorg k ieomdrwb bg eobk/

Gorpg ikz jkpkjrgpzrdjkz dc|eprkorgz bg iez crebez gz|gjrpeaerecrpdjez gzro6;/ Mpko k|idjk`didbkb rkore |kpk zdzrgckz epmodjez g doepmodjez/

0/ Icdrgz bg bgrgjjdo bg ;


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K3 iem \e%\r3 ` J

Go gzrk gjwkjdo K gz ik k`zep`kojdk bg ik bdzeiwjdo {wg gz wok ckmodrwbkbdcgozdeoki> gz wok jeozrkorg iikckbk jegadjdgorg bg k`zeprdqdbkb ceikp (zggx|pgzk go cei#; I jc#;$) zw qkiep bg|gobg bg ik gz|gjdg k`zep`gorg) bg ikieomdrwb bg eobk t bgi bdzeiqgorg jeozdbgpkbe> J pg|pgzgork ik jeojgorpkjdoceikp bg ik zwzrkojdk k`zep`gorg t ` ik ieomdrwb bg ik jgibk {wg jeordgog ikzwzrkojdk k`zep`gorg gx|pgzkbk go jc/

Go ik e`rgojdo bg ik igt bg Ikc`gpr#@ggp zg jeozdbgpk {wg6

;/ Ik pkbdkjdo dojdbgorg gz ceoejpecrdjk/

0/ Ikz gz|gjdgz k`zep`gorgz zeo dobg|gobdgorgz go gi |pejgze bg k`zepjdo/

:/ Gi |pejgze bg k`zepjdo ejwppg go wo qeiwcgo bg zgjjdo rpkozqgpzki wodaepcg/

2/ GZ\GJRPEAERCGRPE WQ#QDZD@IG

Kjrwkicgorg gxdzrgo gz|gjrpeaercgrpez bg wo zeie hkv t be`ig hkv) zdgobe gzrezirdcez iez cz wrdidvkbez/

Wo gz|gjrpeaercgrpe WQ#QDZ bg be`ig hkv jeordgog wok awgorg gcdzepk bgpkbdkjdo wirpkqdeigrk {wg |kzk k rpkqz bg wo ceoejpeckbep {wg zgigjjdeok wokieomdrwb bg eobk bgrgpcdokbk {wg/ k jeordowkjdo) gz bdqdbdbk go bez hkjgz/ Wok|kzk k rpkqz bg wok bdzeiwjdo {wg jeordgog gi jec|wgzre epmodje (hkv bg ikcwgzrpk$ t ik erpk |kzk k rpkqz bg ik jgibk bg pgagpgojdk {wg jeordgog odjkcgorggi bdzeiqgorg (hkv bg pgagpgojdk$/

Gi bgrgjrep cdbg bg aepck jeordowk ik pgikjdo bg dorgozdbkb gorpg gi hkv bg iwv{wg krpkqdgzk ik jgibk bg pgagpgojdk t (DP$ t gi hkv bg iwv {wg krpkqdgzk ik jgibk{wg jeordgog gi jec|wgzre epmodje (DC$/ Wo pgmdzrpkbep rpkvk wok mpadjk(gz|gjrpe$ bg ik k`zep`kojdk bg ik cwgzrpk apgorg k ik ieomdrwb bg eobk t) |eprkore) bg wo gz|gjrpe WQ zg gxrpkg bdpgjrkcgorg gi qkiep bg ik ieomdrwb bg eobkcxdck (ckx$ t bg ik k`zep`kojdk/


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7/ \PE\DGBKBGZ CGRDIBE\K

Oec`pgz6 :#Hdbpexd#k#cgrdi#I#rdpezdok zgz{wdhdbpkrkbkI#: #(: )2#Bdhdbpexdagodi$#0#cgrdikikodok zgz{wdhdbpkrkbkBgzjpd|jdo6 \eiqe adoe) ìkoje e kckpdiie jikpe/

Zeiw`didbkb6 Zeiwìg go jdbe jiephbpdje bdiwdbe> |eje zeiwìg go kmwk tidmgpkcgorg zeiwìg go kijehei) jkzd dozeiwìg go rgp bdgridje/

Pgkjjdeogz kbqgpzkz/

Zecoeigojdk) zg{wgbkb bg èjk) jgakigk) gbgck bg cdgc`pez doagpdepgz |eppgrgojdo bg zebde t kmwk) adg`pg (kzejdkbk) k qgjgz) jeo bdzawojdo hg|rdjk

zgqgpk$ t kogcdk hgceirdjk (k|kpgjg go cgoez bg 7' bg iez |kjdgorgz {wg bko|ezdrdqk ik |pwg`k bg Jeec`z bdpgjrk$/

\pgjkwjdeogz t kbqgprgojdkz/

Ik cgrdibe|k |wgbg bdzcdowdp e dohd`dp gi aiwfe bg zkidqk jeorpd`wtgobe ki bgzkppeiiebg jkpdgz) goagpcgbkb |gpdebeorki t jkobdbdkzdz epki/ Bg`g wrdidvkpzg jeo jwdbkbego |pgzgojdk bg dozwadjdgojdk jepeokpdk) kogcdk hgceirdjk kwredocwog) bdzawojdohg|rdjk) bg|pgzdo cgorki) goagpcgbkb bg \kpndozeo t bdzawojdo pgoki/ Gzkjeozgfkìg hkjgp bgrgpcdokjdeogz bg ik awojdo hg|rdjk jeo dorgpqkiez|gpdbdjez bwpkorg ikz |pdcgpkz zgdz k bejg zgckokz bg rpkrkcdgore e go

jwki{wdgp cecgore go {wg k|kpgvjk adg`pg |ep jkwzk dogx|idjkìg/

Dorgpkjjdeogz/

Gi wze zdcwiroge jeo kordjekmwikorgz bgpdqkbez bg ik jwckpdok e dobkobdeok|wgbg kwcgorkp gi gagjre kordjekmwikorg bg gzrez apckjez/ Ik kbcdodzrpkjdojeo kordbg|pgzdqez rpdjjidjez) kokimzdjez e korddoaikckrepdez oe gzrgpedbgz (KDOG$e gzrpmgoez t koepxdjez (gxjg|re ik agoaiwpkcdok$ |wgbg bdzcdowdp iez gagjrezkordhd|gprgozdqez bg ik cgrdibe|k/

Gi wze fwore jeo hkie|gpdbei |wgbg bkp iwmkp k gagjrez cgorkigz dobgzgkìgz(bgzepdgorkjdo) igordrwb bg iez |pejgzez cgorkigz$/


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Gi wze zdcwiroge jeo igqebe|k |wgbg kirgpkp iez gagjrez kord|kpndozeodkoez bgzrk> ik cgrdibe|k |wgbg |pebwjdp hd|gpgxjdrk`didbkb go |kjdgorgz rpkrkbez jeo

dohd`dbepgz bg ik ceoekcdoeexdbkzk (DCKE$/

Ik kbcdodzrpkjdo fwore jeo kcdokz qkze|pgzepkz zdc|krdjecdcrdjkz |wgbgbdzcdowdp gi gagjre hd|ergozep bg ik cgrdibe|k t |ergojdkp gi gagjre qkze|pgzep bggzrez cgbdjkcgorez/ Ik kzejdkjdo jeo kijehei e bg|pgzepgz bgi ZOJ |wgbg|ergojdkp iez gagjrez bg|pgzepgz bg kc`ez apckjez ze`pg k{wi/ \ep irdce) ikcgrdibe|k |wgbg kwcgorkp ikz jeojgorpkjdeogz zpdjkz bg |peikjrdok g jdorgpagpdpjeo iez gagjrez bg ik `pecejpd|rdok/

Jeorpkdobdjkjdeogz/

Ik cgrdibe|k gzr jeorpkdobdjkbk jwkobe gxdzrgo ikz zdmwdgorgz gordbkbgz jiodjkz6

Goagpcgbkb hg|rdjk kjrdqk/ Hg|krdrdz/ Jdppezdz/ Hd|gpzgozd`didbkb k jwki{wdgpk bg iez jec|eogorgz bg ik apcwik/ Zd ik kbcdodzrpkjdo |pgqdk bg gzrg apckje awg kzejdkbk jeo goagpcgbkb

hg|rdjk/

\pgzgorkjdeogz Jecgpjdkigz Cgrdibe|k

Kibecgr> Be|kmpkob> Be|krpki> C/ Adokbdgr> C/ Ak`pk/ Ik`epkrepde Cgpjn

Jezrez6 ;m W"Z ;:/2< ) 7m W"Z 20/4


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DQ/ G[WD\E

Gz|gjrpeaercgrpe WQ/@kikovk kokirdjk/

Q/ PGKJRDQEZ

Cgrdibe|k/

Hgicjgii/

Gzrgkpkre bg ckmogzde/jdbe jiephbpdje jeojgorpkbe/

QD/ \PG\KPKJDO BG ZEIWJDEOGZ

;/ jdbe jiephbpdje


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QDDD/ \PG\KPKJDO BG \IKJG@E 0/7m

\gzkp 0/2=7m bg Hgicjgi t 07cm bg gzrgkpkre bg ckmogzde) |kzkpiez k wok `eizkbg |eidgrdigoe jhdjk t cgvjikp hecemogkcgorg bg aepck jdpjwikp/

DX/ ZGIGJJDO BG IEZ CREBEZ KOKIRDJEZ K BGZKPPEIIKP

\pdcgpkcgorg ik cgrdibe|k gz wo kcdoejdbe) |ep ie {wg zg |ebpk akjdidrkp ikjwkordadjkjdo |ep kbdjdo bg odohdbpdok) {wg bk wok jeiepkjdo |p|wpk go zeiwjdogo jwki |ebpk cgbdpzg go ie {wg pgadgpg zw dorgozdbkb |ep gz|gjrpeaerecgrpkqdzd`ig go gi jwki ik dorgozdbkb bg jeiepkjdo bg ik zeiwjdo gz bdpgjrkcgorg|pe|epjdeoki k ik jeojgorpkjdo dodjdki bg cgrdibe|k/

Ik pgkjjdo mgogpki gorpg ik cgrdibe|k t ik odohdbpdok zgpk ik zdmwdgorg6

Jece zgmwobk e|jdo zg rdgog ki mpw|e kcdoe bg ik cgrdibe|k) gi jwki |wgbghkjgpzg pgkjjdeokp jeo jdbe |gpjipdje go cgbde oe kjweze) go gi jwki gi jdbe igrpkozadgpg wo |pero bg kjwgpbe k ik zdmwdgorg pgkjjdo6


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Adokicgorg zg |wgbg k|peqgjhkp ik zeiw`didbkb bg ik cgrdibe|k jeo HJi bdiwbepg|eprkbe go ik AGWC (;


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;/ Gz|gjdadjdbkb

Zg pgkidvk go `kppdbe bg zeiwjdeogz bg |ikjg`e (;


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Bdkmpkck bg aiwfe/

@/ CGREBE

\pg|kpkp rpgz odqgigz bg |ikjg`ez jkpmkbez k 8


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08%;;%;0\mdok ;7 bg ::



:/ Gxkjrdrwb

\pg|kpkp zgdz |ikjg`ez jkpmkbez ki ;


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XD/ JPEOEMPKCK BG KJRDQDBKBGZAGJHK

KJRDQDBKB ;


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XDD/ PGZWIRKBEZ

Gx|gpdcgore *;& Kmdrkjdo bg ik cwgzrpk |ep ;< cdowrez/

K/ Gz|gjdadjdbkb

GZ\GJRPEZ \IKJG@EZ

\ikjgè Oe ; \ikjgè Oe 0

\ikjgè Oe :


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GZ\GJRPEZ K\DZ

K\D Oe ; K\D Oe 0

K\D Oe :


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GZ\GJRPEZ K\D.\IKJG@E

K\D.\IKJG@E Oe ; K\D.\IKJG@E Oe 0

K\D.\IKJG@E Oe :

IEOMDRWB BG EOBK ZGIGJJDEOKBK6 0=4/7 oc


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08%;;%;0\mdok 0< bg ::



\KP CGRPE GZRKB MPKAE BGJEORPKZRG PGZWIRKBE

C REBE

IDOGKIDBKB p


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08%;;%;0\mdok 0; bg ::



Gx|gpdcgore *0

& Kmdrkjdo bg ik cwgzrpk |ep 7 cdowrez/

K/ Idogkidbkb bgi zdzrgck

JKORDBKB KBDJDEOKBK K@ZEP@KOJDK

8


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J/ GxkjrdrwbJKORDBKB KBDJDEOKBK K@ZEP@KOJDK

44)=


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|kpk zeiw`didvkp ik cwgzrpk bg cgrdibe|k) |gpe ki bdzcdowdp ik jkordbkb bg gzrgbdzeiqgorg go ik bgrgpcdokjdo ik jkordbkb bg jdbe |gpjipdje mkzrkbe |kpk gi qdpg

bgi dobdjkbep jpdzrki qdeigrk gpk cwjhe cgoep k ik jkordbkb rgpdjk jkijwikbk jeo`kzg go ik jkordbkb bg cgrdibe|k |gzkbk dodjdkicgorg/ Goreojgz zg |pejgbd kjkc`dkp bg bdzeiqgorg wrdidvobezg bdexkoe) |gpe zg rwqdgpeo iez cdzcez|pe`igckz bg mkzrkp cgoez jdbe |gpjipdje go ik bgrgpcdokjdo/ \ep ie {wg zgbgjdbd oe pgkidvkp gzrg crebe kokirdje |ep gi mpko mkzre bg bdzeiqgorg pg{wgpdbe|kpk pgkidvkp iez |kpcgrpez bg qkidbkjdo bgzgkbez/

Gi crebe kokirdje |pe|wgzre go gi {wg zeie gz ogjgzkpde zeiw`didvkp ik cgrdibe|kt pgkidvkp wok bdiwjdo |kpk zw jwkordadjkjdo |ezrgpdep |ep gz|gjrpezje|kwirpkqdeigrk awg dbgki) ajdi t cz `kpkre) tk {wg zeie zg ogjgzdrk jdbe jiephbpdje


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Go ie {wg pgz|gjrk k iez pgzwirkbez e`rgodbez go gi gx|gpdcgore *0go gi {wg zgkmdr |ep 7 cdowrez ik cwgzrpk |kpk zeiw`didvkp k ik cgrdibe|k zg |wgbe bgcezrpkp

{wg z doaiwtg bgckzdkbe gi rdgc|e bg kmdrkjdo bg ik cgrdibe|k jeo gi jdbejiephbpdje


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XQ/ KOGXEZ (JIJWIEZ$

GZROBKP \KPK REBEZ IEZ JKIJWIEZ

Gzrobkpcm K`zep`kojdk44/4


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Jkijwie bg KobgqkH


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p


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GXKJRDRWB

Jkordbkbkbdjdeokbk K Jkordbkbpgjw|gpkbk ' pgje`pe

Gx ; 44/4


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08%;;%;0\mdok 04 bg ::



IDOGKIDBKB BGI ZDZRGCK

* Jeojgorpkjdom%ci

K

8


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H


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JEGADJDGORG BG K@ZEPRDQDBKB CEIKP

Go HJi


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XQD/ @D@IDEMPKAK;/ Akpckje|gk bg iez Gzrkbez Wodbe Cgxdjkoez) ;

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