INFORMATION ABOUT THE JOURNALDEVELOPMENT (ISSN 0950-1991) is a continuation of Journal of Embryology and Experimental Morphology (ISSN 0022-0752).

DevelopmentThe aim of Development is to act as aforum for all research that offers agenuine insight into mechanisms ofdevelopment. Manuscripts will beconsidered primarily with respect to thisaim.

Studies on both plant and animaldevelopment are welcome and can befocused upon any aspect of thedevelopmental process, at all levels ofbiological organization from themolecular and cellular to the tissuelevels.

What Development offers(i) Wide international circulation(ii) Fast publication - average 13 weeksfrom acceptance(iii) Fast editorial processing(iv) No page charges(v) 200 free reprints(vi) Free colour reproduction (at theeditor's discretion).

Rapid publicationDevelopment now offers rapidpublication (average 9 weeks fromacceptance): the following criteriaapply:(i) the revised manuscript isaccompanied by a corresponding word-processor disk(ii) no colour plates(iii) author does not require to seeproofs(iv) 200 free reprints only(v) manuscript conforms to journalstyle i.e. no subediting necessary - seeInformation for contributors,(vi) Figures are labelled in journalstyle.

Subscription ratesUSA, Canada and Mexico: InstitutionalUS$885; Individual US$105.Rest of the World: Institutional £510;Individual £75.(All prices include post and packaging).

Number of issuesDevelopment in 1991 will have 12normal issues and 2 caseboundsupplements. The 12 normal issues willbe in the form of 3 volumes (111, 112,113) each of 4 parts. In 1991 theSupplements will be 'Molecular andCellular Basis of Pattern Formation'and 'Developmental Neurobiology'.

OrdersOrders for 1991, which can be in £Sterling/Dollars or using Access/Visacredit cards, should be sent to PortlandPress Ltd, PO Box 32, Commerce Way,Colchester CO2 8HP, UK[telephone Colchester (0206) 46351;24-hour ordering by Fax (0206) 549331- USA 44 206 549331] or to yournormal agent or bookseller.Orders must be accompanied bypayment.

DeliveryCopies of the journal for subscribers inthe USA and Canada are sent by air toNew Jersey for delivery with theminimum delay (second class postagepaid at Rahway, NJ and at additionalmailing offices).

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Send address corrections toDevelopment, c/o Mercury AirfreightInternational Inc., 2323 RandolphAvenue, Avenel, New Jersey 07001,USA (US Mailing Agent).

ReagentsPublication of a paper in this journalimplies that authors will make availablespecialized reagents (for exampleantibodies, DNA probes) to otherscientists in the field who require themfor bona fide purposes.

For detailed instructions to authors,please see back cover.

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Copyright and reproduction(i) Authors may make copies oftheir own papers in this journalwithout seeking permission fromThe Company of Biologists Limited,provided that such copies are for freedistribution only: they must not besold.

(ii) Authors may re-use their ownillustrations in other publicationsappearing under their own namewithout seeking permission.

(iii) Specific permission will not berequired for photocopying copyrightmaterial in the followingcircumstances.

(a) For private study, provided thecopying is done by the personrequiring its use, or by an employeeof the institution to which he/shebelongs, without charge beyond theactual cost of copying.

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(iv) For all other matters relating tothe reproduction of copyrightmaterial written application must bemade to

Dr R. J. Skaer,Company Secretary,The Company of Biologists Limited,Department of Zoology,Downing Street,Cambridge CB2 3EJ,UK.

INFORMATION FOR CONTRIBUTORSManuscripts

Send to: Development Editorial Office,Dept of Zoology, University ofCambridge, Downing St, CambridgeCB2 3EJ, UK. Tel: (0223) 311789 ordirect to one of the editors.USA papers should be sent direct to:Dr D. Melton, Department ofBiochemistry and Molecular Biology,Harvard University, 7 Divinity Avenue,Cambridge, MA 02138, USA,Dr G. Rubin, Department of Molecularand Cell Biology, Box 539, LSABuilding, University of California,Berkeley, CA 94720, USA,or Dr T. Jessell, Center forNeurobiology and Behavior, ColumbiaUniversity, 722 West 168th Street,New York, NY 10032, USA.European papers can be sent to:Dr W. J. Gehring, Department of CellBiology, Biozentrum, University ofBasel, Klingelbergstrasse 70, CH-4056,Basel, Switzerland.Manuscripts should be in English,typewritten, double spaced, on one sideof the paper, and the pages numbered.Papers should be fully ready for press,since revision in proof will not bepossible. The author is requested toprovide three copies of the typescriptand figures, and should keep a copy.

Author's disks

Development can use author's word-processor disks (5i and 3i" instead ofrekeying accepted articles. Thisincreases both the speed and accuracyof proof production. With your letter ofprovisional acceptance, you will be sentfull instructions on formatting andsaving your manuscript on disk. Pleasesend a copy of your disk with 2 printedcopies of your final revised manuscript.Disks will be returned.

PrOOfS

Authors will receive two sets of proofs,one for correction and return toEditorial Office. Authors may berequired to pay for alterations in proofother than those needed to correctprinter's errors.

Layout and style

A short title of not more than 40characters, for use as page headings,should be supplied and at least 3 keywords for indexing papers.A summary must be provided at thebeginning of the text. It should notexceed 500 words. Acknowledgementsshould be placed before the list ofreferences.The list of references must be given inalphabetical order of author's names.The titles of journals should beabbreviated in accordance with theWorld List of Scientific Periodicals,4th edn (1963). The following style isused:Lawrence, P. and Johnston, P. (1988).

Cell lineage of the Drosophilaabdomen. Development 99,197-208.

Rossant, J. (1977). Cell commitmentin early rodent development. InDevelopment in Mammals, vol. 2(ed. M. H. Johnson), pp. 119-150.Amsterdam: North Holland.

Citations in the text are given in thefollowing form: Jones and Smith(1960) or (Jones and Smith, 1960).Where there are more than twoauthors citations should be in theform (Jones et al. 1960). Where morethan one paper by the same author(s)have been published in the same yearthey are cited as Jones (1960a), Jones(1960b) etc.Unpublished observations, includingresults submitted for publication,should be cited as such in the textonly, and not in the reference list.Personal communications, i.e. theunpublished observations of otherscientists, will only be published whensubstantiated by written permission.

Tables

Please submit on separate sheetstogether with their titles and legends.

Authors will receive 200 reprints freeof charge and may order additionalcopies when proofs are returned.

Text figures/photographs

These should be numbered in a singleseries (Fig. 1, Figs 2, 3 etc), in theorder in which they are referred to inthe text. Legends for all illustrationsshould be typed together, separatelyfrom the main text. Authors shouldsubmit three copies for reviewers.Copies of the photographic plates mustbe of suitable standard for reviewers tojudge the quality of the work;photocopies are not acceptable.Original figures should be kept by theauthor until the manuscript has beenaccepted for publication.Text figures and photographs ideallyshould be at final size and occupyeither 1 or 2 columns. The maximumprinted size for illustrations is210 mm x 168 mm for a whole page or210 mmX81 mm for a single column.Labelling can be inserted by the authorproviding that the lattering conforms tojournal style and size. Otherwiselabelling should be indicated on aduplicate marked set of prints or on atracing-paper overlay bearingaccurately marked outlines of theobjects indicated. Figure parts shouldbe labelled in upper case and letteringon the plates should be in lower case.Magnification should be indicated,where relevant, by a scale line on orbeside the illustration. Each illustrationshould have the name of the authorand the figure number written on theback, together with indication oforientation and any proposed reductionin size.

These can be reproduced free of chargeat the discretion of the editor. Anycharge for excessive use of colour willalso be at the editor's discretion.

Copyright

In order to give The Company ofBiologists Limited authority to dealwith matters of copyright, authors willbe required to assign to them the copy-right of any article published in thejournal.

DEVELOPMENT

TRAVELLINGFELLOWSHIPS

The journal is pleased to announce a new travelling fellowship program that is in keepingwith The Company of Biologists' commitment to support research scientists.

In 1991 DEVELOPMENT is offering

FIVE TRAVELLING FELLOWSHIPS

of up to $1500 each

Graduate and postdoctoral students are invited to apply to the Editors in 1991 for funds toassist travel and expenses involved in visits to other laboratories.

Applications, which should be accompanied by a curriculum vitae, an account of thework to be done and a full breakdown of the costs involved, should include a letter ofrecommendation from the head of the laboratory in which the applicant is presentlyworking and from the head of the laboratory in which the work will be done.

Applications should be sent to C. C. WylieThe Company ot Biologists Limited

Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK

The Editors in awarding the Fellowships will be guided by the excellence of thecandidates, and the importance and innovative quality of the work to be done.

STZ\

Peter HausenMetta Riebesell"

Development o fXenopus LaevisAn Atlas of the Histology

Verlag der Zeitschriftfur Naturforschung j r

1991. Approx. 160 pp. 42 figs. Hardcover DM 198,- ISBN 3-54O-5374O-6

Xenopus laevis is the key model for developmental, differential and embryological studies in vertebrates.Using molecular biological techniques it has become possible within the last few years to analyze developmentalprocesses up to the level of genes. On obtaining results it is necessary to correlate them with morphological andhistological stages. This excellent work documents and describes such developmental stages in finite detail.

After an informative introduction to The Early Development of Xenopuslaevis follows the highlight of the book, namely the 42 plates, each consistingof at least four high resolution micrographs. The reader is thus provided witha histological presentation of immaculate quality. Each plate is comple-mented by a schematic diagram describing the details shown on the plate, anadditional scheme indicating the section and an explanatory short text,making this a potentially highly sought after work.

Jointly published by Springer-Verlag Berlin Heidelberg New York London Paris TokyoHong Kong Barcelona and Verlag Zeitschrift fur Naturforschung, Tubingen

a Heidelberger Plsu 3, W-1000 Berhn 33, F R. Gerrainy D 175 Fifth Are., New York, NY H»10, USA d 8 AJenndra Rd, London SW19 7JZ, EngUndD 26, rue del C»nnej, F-75005 Pirn, France D 37-3, Hongo 3-cbome, Buniyo-ku, Tokyo 113, JipanO Room 701, Mirror Tower, 61 Mody Road, Tiunihjuui, Kowioon, Hong Kong D Avmguda Dugoiul, 468-4°C, E-08006 Barcelona, Spain UnJ0.166/V/l

• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •• • • • • • • • • • • • • • • • « * • • • • • • • • • • • • • • • • • • • • • • • • • • • • •

BRITISH SOCIETY FOR DEVELOPMENTAL BIOLOGYand

THE GENETICAL SOCIETY

AUTUMN MEETING18TH-19TH SEPTEMBER 1991

UNIVERSITY OF LANCASTER

GENETIC AND DEVELOPMENTAL CONSEQUENCESOF INSERTIONAL MUTAGENESIS

SPEAKERSE.Coen (John Innes Institute)

G. Coupland (AFRC IPSR Cambridge)C. Dean (Sainsbury Laboratory)

K. Feldman (University of Arizona)J. Jones (Sainsbury Laboratory)

C. O'Kane (Warwick)M. Krasnow (Stanford)

K. O'Hare (Imperial College)K. Kaiser (Glasgow)

R. Beddington (Edinburgh)D. Melton (Edinburgh)

F. Grosveld (NIMR London)J. Mullins (Edinburgh)

Travel Funds:Junior members of the BSDB may apply for contributions towardsthe cost of attending the meeting from the Treasurer of the Society

FURTHER INFORMATION AND BOOKING FORMS:Alan Shirras

Institute of Environmental and Biological SciencesUniversity of Lancaster

Lancaster LA1 4YQ

&, • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •

Xenopusembryology

-basic embryological techniques

-mesoderm-inducing factor assays

-lineage labelling

-wholemount immunocytochemistry

- in situ hybridization

Organizers: Jonathan SlackJim Smith

Venue: Department of Zoology and Wadham College,Oxford University, UK. September 8-15 1991.

If you wish to apply to participate, or requirefurther information about the course content, pleasewr i te to Dr J.M.W.Slack, I.C.R.F. Developmental BiologyUnit, Department of Zoology, South Parks Road, OxfordOXl 3PS, United Kingdom.

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INFORMATION FOR CONTRIBUTORSManuscripts

Send to: Development Editorial Office,Dept of Zoology, University ofCambridge, Downing St, CambridgeCB2 3EJ, UK. Tel: (0223) 311789 ordirect to one of the editors.USA papers should be sent direct to:Dr D. Melton, Department ofBiochemistry and Molecular Biology,Harvard University, 7 Divinity Avenue,Cambridge, MA 02138, USA,Dr G. Rubin, Department of Molecularand Cell Biology, Box 539, LSABuilding, University of California,Berkeley, CA 94720, USA,or Dr T. JesseU, Center forNeurobiology and Behavior, ColumbiaUniversity, 722 West 168th Street,New York, NY 10032, USA.European papers can be sent to:Dr YV. J. Gehring, Department of CellBiology, Biozentrum, University ofBasel, Klingelbergstrasse 70, CH-4056,Basel, Switzerland.Manuscripts should be in English,typewritten, double spaced, on one sideof the paper, and the pages numbered.Papers should be fully ready for press,since revision in proof will not bepossible. The author is requested toprovide three copies of the typescriptand figures, and should keep a copy.

Author's disks

Development can use author's word-processor disks (5i and 3i" instead ofrekeying accepted articles. Thisincreases both the speed and accuracyof proof production. With your letter ofprovisional acceptance, you will be sentfull instructions on formatting andsaving your manuscript on disk. Pleasesend a copy of your disk with 2 printedcopies of your final revised manuscript.Disks will be returned.

Proofs

Authors will receive two sets of proofs,one for correction and return toEditorial Office. Authors may berequired to pay for alterations in proofother than those needed to correctprinter's errors.

Layout and style

A short title of not more than 40characters, for use as page headings,should be supplied and at least 3 keywords for indexing papers.A summary must be provided at thebeginning of the text. It should notexceed 500 words. Acknowledgementsshould be placed before the list ofreferences.The list of references must be given inalphabetical order of author's names.The titles of journals should beabbreviated in accordance with theWorld List of Scientific Periodicals,4th edn (1963). The following style isused:Lawrence, P. and Johnston, P. (1988).

Cell lineage of the Drosophilaabdomen. Development 99,197-208.

Rossant, J. (1977). Cell commitmentin early rodent development. InDevelopment in Mammals, vol. 2(ed. M. H. Johnson), pp. 119-150.Amsterdam: North Holland.

Citations in the text are given in thefollowing form: Jones and Smith(1960) or (Jones and Smith, 1960).Where there are more than twoauthors citations should be in theform (Jones et al. 1960). Where morethan one paper by the same author(s)have been published in the same yearthey are cited as Jones (1960a), Jones(1960b) etc.

Unpublished observations, includingresults submitted for publication,should be cited as such in the textonly, and not in the reference list.Personal communications, i.e. theunpublished observations of otherscientists, will only be published whensubstantiated by written permission.

Tables

Please submit on separate sheetstogether with their titles and legends.

Reprints

Authors will receive 200 reprints freeof charge and may order additionalcopies when proofs are returned.

Text figures/photographs

These should be numbered in a singleseries (Fig. 1, Figs 2, 3 etc), in theorder in which they are referred to inthe text. Legends for all illustrationsshould be typed together, separatelyfrom the main text. Authors shouldsubmit three copies for reviewers.Copies of the photographic plates mustbe of suitable standard for reviewers tojudge the quality of the work;photocopies are not acceptable.Original figures should be kept by theauthor until the manuscript has beenaccepted for publication.Text figures and photographs ideallyshould be at final size and occupyeither 1 or 2 columns. The maximumprinted size for illustrations is210mmxl68mm for a whole page or210mmx81 mm for a single column.Labelling can be inserted by the authorproviding that the lattering conforms tojournal style and size. Otherwiselabelling should be indicated on aduplicate marked set of prints or on atracing-paper overlay bearingaccurately marked outlines of theobjects indicated. Figure parts shouldbe labelled in upper case and letteringon the plates should be in lower case.Magnification should be indicated,where relevant, by a scale line on orbeside the illustration. Each illustrationshould have the name of the authorand the figure number written on theback, together with indication oforientation and any proposed reductionin thet

Colour plates

These can be reproduced free of chargeat the discretion of the editor. Anycharge for excessive use of colour willalso be at the editor's discretion.

Copyright

In order to give The Company ofBiologists Limited authority to dealwith matters of copyright, authors willbe required to assign to them the copy-right of any article published in thejournal.