4
KEYNOTE PRESENTATIONS INCLUDE: Dr Bernard A. Fox, Chief, Molecular & Tumour Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, USA Professor David W.Scott, Vice Chair for Research Department of Medicine, Uniformed Services University of Health Sciences, USA Dr Alan Korman, Vice President, Discovery Research, Bristol Myers Squibb, USA Dr Michael Covington, CMC Senior Director, Regulatory Affairs, Dendreon, USA Dr Michael Hanna, Founder and Chairman, Vaccinogen, USA Dr Kalpit Vora, Director, Vaccine Basic Research, Merck, USA EUROPE’S EVENT OF CHOICE FOR SENIOR LEVEL IMMUNOTHERAPY PROFESSIONALS: Dr Gary Starling, Director, Oncology Biologics, Abbott, USA Professor Sonia Quaratino, Senior Medical Director and Immunology Advisor, Merck Serono, Germany Dr John Trizzino, CEO, ImmunoVaccine, Canada Dr Harpreet Singh, Managing Director, Chief Scientific Officer, Immatics Biotechnologies GmbH, Germany Dr Reiner Laus, President and Chief Executive Officer, BN ImmunoTherapeutics, USA Dr Johannes Streffer, Senior Director, Neuroscience Development, Janssen – Pharmaceutical Companies of Johnson and Johnson, Belgium Dr Matthew Albert, Director, Research, INSERM, France Professor Inge Marie Svane, MD, Director , Center for Cancer ImmuneTherapy- CCIT, Department of Oncology and Haematology, Herlev Hospital, Copenhagen University, Denmark Dr Gary Wood, President & CEO, TVAX Biomedical, USA Dr Genevieve Inchauspe, Department Head, Infectious Diseases, Transgene, France Dr Richard Harrop, Head, Clinical Analysis, Oxford Biomedica, UK Dr Michael Har-Noy, CEO/CTO, Immunovative Therapies, Israel Professor Viktor Umansky, German Cancer Research Center, Heidelberg and University Hospital Mannheim, Germany Dr William Grossman, Senior Vice President, Research & Development, Biothera, USA Dr Ronald Ellis, Senior Vice President, Research and Development, NasVax Ltd, Israel Dr Guy-Charles F. de La Horie, CEO, NeoVacs, France Dr Khursheed Anwer, President and CSO, EGEN, Inc., USA Dr Takashi Kei Kishimoto, Chief Scientific Officer, Selecta Biosciences, USA Dr Charles A. Nicolette, Chief Scientific Officer, Vice President, Research and Development, Argos Therapeutics, Inc., USA Dr Cedrik M. Britten, Vice President R&D, Ribological GmbH, Germany Pre-Conference Workshop W: Tuesday 4th December 2012 Clinical Trial Design: The Key to Success Leaders: Dr John Trizzino, ImmunoVaccine, Canada Dr Gary Wood, TVAX Biomedical, USA Dr Charles A. Nicolette, Argos Therapeutics, USA Dr David Edwards, Cancer Research UK, UK Dr Thomas Felzmann, Activartis Biotech GmbH, Germany Evening Seminar X: Wednesday 5th December 2012 Practical Advice on Successfully Filing IND Applications Leader: Dr Michael Covington, Dendreon, USA Post-Conference Workshop Y: Friday 7th December 2012 Antibodies: Targeted Therapy as an Immunomodulator Leaders: Dr Alan Korman, Bristol Myers Squibb, USA & Dr Gary Starling, Abbott, USA Maximise your time out of the office with these BRAND NEW training courses! Find winning strategies to improve your immunotherapy development programme Hear the latest research driving immunotherapy development and new applications for increasing immune response: Updates and case studies from Dendreon, Bristol Myers Squibb, Merck, Vaccinogen and INSERM Discover which immunotherapy approaches are most effective and successful: 8 case studies covering active, passive and non- specific immunotherapy Generate the correct pre-clinical data to ensure successful development into the clinic: Data from Argos Therapeutics, Biothera, Janssen,Uniformed Services University and more Establish efficient and cost-effective clinical trials with a dedicated session on reliable patient populations and immune monitoring techniques Work out the best delivery method for your immunotherapy with leading industry insight on local and nanodelivery Sponsor: Register online: www.informa-ls.com/immunotherapies Bookings Hotline +44 (0)20 7017 7481 Fax +44 (0)20 7017 7823 email: [email protected] Please quote: CQ3486 Bringing together industry and academia to maximise the immune response, optimise clinical development and boost commercial success of immunotherapies Wednesday 5 – Thursday 6 December 2012, Sheraton Brussels Hotel, Brussels, Belgium Informa Life Sciences’ Inaugural Immunotherapies & Cancer Vaccines With 3 of the top 10 drugs predicted to be immunotherapeutics by 2014, discover how leading pharma companies are maximising development programmes for this lucrative market Media partners: 25+ Speakers – 25+ Case Studies – 10+ Hours of Networking and Partnering Opportunities PART OF 50% discounts for SMEs and Academics

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Page 1: Informa Life Sciences’ Inaugural Immunotherapies & Cancer ... · Informa Life Sciences’ Inaugural Immunotherapies & Cancer Vaccines ... Immunotherapy is the premier biological

KEYNOTE PRESENTATIONS INCLUDE: Dr Bernard A. Fox, Chief, Molecular & Tumour Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, USA

Professor David W.Scott, Vice Chair for Research Department of Medicine, Uniformed Services University of Health Sciences, USA

Dr Alan Korman, Vice President, Discovery Research, Bristol Myers Squibb, USA

Dr Michael Covington, CMC Senior Director, Regulatory Affairs, Dendreon, USA

Dr Michael Hanna, Founder and Chairman, Vaccinogen, USA

Dr Kalpit Vora, Director, Vaccine Basic Research, Merck, USA

EUROPE’S EVENT OF CHOICE FOR SENIOR LEVEL IMMUNOTHERAPY PROFESSIONALS:Dr Gary Starling, Director, Oncology Biologics, Abbott, USAProfessor Sonia Quaratino, Senior Medical Director and Immunology Advisor, Merck Serono, GermanyDr John Trizzino, CEO, ImmunoVaccine, CanadaDr Harpreet Singh, Managing Director, Chief Scientific Officer, Immatics Biotechnologies GmbH, GermanyDr Reiner Laus, President and Chief Executive Officer, BN ImmunoTherapeutics, USADr Johannes Streffer, Senior Director, Neuroscience Development, Janssen – Pharmaceutical Companies of Johnson and Johnson, BelgiumDr Matthew Albert, Director, Research, INSERM, FranceProfessor Inge Marie Svane, MD, Director , Center for Cancer ImmuneTherapy- CCIT, Department of Oncology and Haematology, Herlev Hospital, Copenhagen University, DenmarkDr Gary Wood, President & CEO, TVAX Biomedical, USADr Genevieve Inchauspe, Department Head, Infectious Diseases, Transgene, FranceDr Richard Harrop, Head, Clinical Analysis, Oxford Biomedica, UKDr Michael Har-Noy, CEO/CTO, Immunovative Therapies, IsraelProfessor Viktor Umansky, German Cancer Research Center, Heidelberg and University Hospital Mannheim, GermanyDr William Grossman, Senior Vice President, Research & Development, Biothera, USADr Ronald Ellis, Senior Vice President, Research and Development, NasVax Ltd, IsraelDr Guy-Charles F. de La Horie, CEO, NeoVacs, FranceDr Khursheed Anwer, President and CSO, EGEN, Inc., USADr Takashi Kei Kishimoto, Chief Scientific Officer, Selecta Biosciences, USADr Charles A. Nicolette, Chief Scientific Officer, Vice President, Research and Development, Argos Therapeutics, Inc., USADr Cedrik M. Britten, Vice President R&D, Ribological GmbH, Germany

Pre-Conference Workshop W: Tuesday 4th December 2012

Clinical Trial Design: The Key to SuccessLeaders: Dr John Trizzino, ImmunoVaccine, Canada Dr Gary Wood, TVAX Biomedical, USA Dr Charles A. Nicolette, Argos Therapeutics, USA Dr David Edwards, Cancer Research UK, UK Dr Thomas Felzmann, Activartis Biotech GmbH, Germany

Evening Seminar X: Wednesday 5th December 2012

Practical Advice on Successfully Filing IND ApplicationsLeader: Dr Michael Covington, Dendreon, USA

Post-Conference Workshop Y: Friday 7th December 2012

Antibodies: Targeted Therapy as an ImmunomodulatorLeaders: Dr Alan Korman, Bristol Myers Squibb, USA &

Dr Gary Starling, Abbott, USA

Maximise your time out of the office with these BRAND NEW training courses!

Find winning strategies to improve your immunotherapy development programme• Hear the latest research driving immunotherapy development

and new applications for increasing immune response: Updates and case studies from Dendreon, Bristol Myers Squibb, Merck, Vaccinogen and INSERM

• Discover which immunotherapy approaches are most effective and successful: 8 case studies covering active, passive and non-specific immunotherapy

• Generate the correct pre-clinical data to ensure successful development into the clinic: Data from Argos Therapeutics, Biothera, Janssen,Uniformed Services University and more

• Establish efficient and cost-effective clinical trials with a dedicated session on reliable patient populations and immune monitoring techniques

• Work out the best delivery method for your immunotherapy with leading industry insight on local and nanodelivery

Sponsor:

Register online: www.informa-ls.com/immunotherapiesBookings Hotline +44 (0)20 7017 7481

Fax +44 (0)20 7017 7823email: [email protected]

Please quote: CQ3486

Bringing together industry and academia to maximise the immune response, optimise clinical development and boost commercial success of immunotherapies

Wednesday 5 – Thursday 6 December 2012, Sheraton Brussels Hotel, Brussels, Belgium

Informa Life Sciences’ Inaugural

Immunotherapies & Cancer Vaccines

With 3 of the top 10 drugs predicted to be immunotherapeutics by

2014, discover how leading pharma companies

are maximising development programmes

for this lucrative

market

Media partners:

25+ Speakers – 25+ Case Studies – 10+ Hours of Networking and Partnering Opportunities

PART OF

50% discounts

for SMEs and Academics

Page 2: Informa Life Sciences’ Inaugural Immunotherapies & Cancer ... · Informa Life Sciences’ Inaugural Immunotherapies & Cancer Vaccines ... Immunotherapy is the premier biological

To Register Tel: +44 (0)20 7017 7481 Fax: +44 (0)20 7017 7823 Email: [email protected] Web: www.informa-ls.com/immunotherapies Please Quote: CQ3486

DAY ONE: WEDNESDAY 5 DECEMBER 201208.00 Registration and Opening of the VIC Congress Exhibition Hall

08.55 Chairperson’s Opening

Cutting-Edge Research Driving Immunotherapy Development

09.05 THE LATEST DEVELOPMENT UPDATES ON PROVENGE Sipuleucel-T for prostate cancer: Development of the first approved active

immunotherapy Sipuleucel-T, the first FDA approved autologous cellular immunotherapy for cancer,

is designed to stimulate the immune system against prostate cancer. Challenges in the commercialisation of Sipuleucel-T in the United States and Europe will be discussed including regulatory, education, supply, reimbursement, and the changing therapeutic landscape.

Dr Michael Covington, CMC Senior Director, Regulatory Affairs, Dendreon, USA

09.35 THE LATEST UPDATES ON THE IMPROVEMENTS TO IPILIMUMAB The latest developments in improving Yervoy, and CTLA-4 and PD-1

Dr Alan Korman, Vice President, Discovery Research, Bristol Myers Squibb, USA

10.05 Potential molecular pathways to modulate for the success of immunotherapies This presentation will discuss pathways to break tolerance (adjuvants and co-stimulations to

overcome immune-anergy and molecules that block immune-inhibitory pathway). These may help focus our understanding why chronic infectious agents and tumours evade immunity.

Dr Kalpit Vora, Director, Vaccine Basic Research, Merck, USA

10.35 Morning Coffee and Poster/Exhibition Viewing Time 11.05 KEYNOTE PRESENTATION The impact of genomic sequencing data in cancer immunotherapy At the cellular level it is clear that cancer is a genetic disease arising as a clone that expands

and grows in an unregulated manner. While it has always been presumed that neoplasia is a consequence of somatic cell mutations, only in the last few years has the magnitude and diversity of these mutations been elucidated by modern DNA sequencing technology. Immunotherapy is the premier biological approach to targeted therapy. This presentation will discuss the consequences of this new knowledge of tumour cell biology to the immunotherapeutic approach to treating cancer.

Dr Michael Hanna, Founder and Chairman, Vaccinogen, USA

11.35 Bladder cancer: Lessons from 35 years of a clinical immunotherapy To find out more information about this presentation, please visit the conference website at

www.informa-ls.com/immunotherapies Dr Matthew Albert, Director, Research, INSERM, France

Novel Approaches for Maximising Immune Response

12.05 Biomarker-guided development of cancer vaccines and combination therapies Immunotherapy development is complex requiring rational selection and combination of

the right antigens, immunomodulators, standard of care and patient population. In this presentation – using two novel peptide-based cancer immunotherapy candidates for treatment of renal cell cancer (IMA901) and colorectal cancer (IMA910) as examples – the use of novel pharmacodynamic and prognostic/predictive biomarkers to rationally guide clinical development of immunotherapy combinations will be discussed.

Dr Harpreet Singh, Managing Director, Chief Scientific Officer, Immatics Biotechnologies GmbH, Germany

SPOTLIGHT PRESENTATION These sessions are hosted by leading companies operating in the field of immunotherapies and

cancer vaccines, and offer an opportunity to learn about the latest developments in the industry. If you would like to host a spotlight presentation, please contact [email protected] or +44 (0) 207 017 4447

12.35 Lunch and partnering time

13.35 Immunostimulatory therapies: Immunocytokines/Cancer vaccines To find out more information about this presentation, please visit the conference website at

www.informa-ls.com/immunotherapies Professor Sonia Quaratino, Senior Medical Director and Immunology Advisor, Merck

Serono, Germany

14.05 Novel monoclonal antibody therapeutic for Alzheimer’s disease Amyloid precursor protein (APP) is a primary molecule in AD pathogenesis. We employ a MAb (BBS)

that binds to the BACE cleavage site on cell-surface APP. Transgenic AD mice treated with BBS MAb compared to control MAb showed significant reductions in intra- and extra-cellular Aß, significantly improved performance in behavioural tests to the same level as that of non-transgenic mice, and reduced levels of astrocytosis indicating improved safety. The rapid cellular internalisation of the MAb after binding to APP may be beneficial for avoiding microglia and complement activation that have been reported for anti-Aß Abs that bind to amyloid plaques. The BBS MAb is a strong candidate for clinical development.

Dr Ronald Ellis, Senior Vice President, Research and Development, NasVax Ltd, Israel

14.35 Immunologic mechanisms driving the combinatorial activity of elotuzumab and lenalidomide in multiple myeloma models

Elotuzumab, a humanised monoclonal antibody, has shown promise as a combination partner of lenalidomide/dexamethasone for the treatment of relapsed or refractory Multiple Myeloma. Randomised Phase 3 clinical studies are underway to examine the effect of elotuzumab in combination with len/dex on progression-free survival in newly diagnosed and relapsed/refractory MM patients. The immunologic mechanisms underlying the combinatorial activity have been dissected in xenograft models in vivo and in vitro using a co-culture model consisting of peripheral blood lymphocytes and Myeloma cell lines.

Dr Gary Starling, Director, Oncology Biologics, Abbott Biotherapeutics, USA

15.05 Perspectives on T cell therapy for treatment of melanoma; a succesfull combination of chemotherapy and immunotherapy

T-cell therapy is a very promising new strategy for treatment of metastatic melanoma and a fascinating example of successful combination of intensive chemotherapy and immunotherapy. Tumour infiltrating lymphocytes (TILs) can be isolated from surgical removed tumour lesion and extensively expanded in vitro. TIL-based therapy is given in three phases; conditioning high-dose chemotherapy, TIL infusion, and high dose IL-2. Impressive objective responses are seen probably with curative potential. New perspectives on this therapy will be discussed.

Professor Inge Marie Svane, MD, Director , Center for Cancer ImmuneTherapy- CCIT, Department of Oncology and Haematology, Herlev Hospital, Copenhagen University, Denmark

15.35 Afternoon Tea, and Poster/Exhibition Viewing Time

16.05 A novel approach to cancer immunotherapy combining cancer cell vaccination and killer T cells

Research suggests that an efficacious immunotherapeutic strategy should involve significant T cell mediated cancer cell killing. We have developed a cancer immunotherapy platform that combines cancer cell vaccination and intravenous infusion of ex vivo-activated killer T cells to produce significant T cell-mediated cancer cell killing. We will discuss results of our research demonstrating the therapeutic benefits that can be achieved with this strategy.

Dr Gary Wood, President & CEO, TVAX Biomedical, USA

16.35 Harnessing the power of the graft vs. tumour effect of non-myeloablative allogeneic stem cell transplants to enhance the effectiveness of cancer vaccine strategies

The immune mechanism of non-myeloablative allogeneic stem cell transplants, called the graft vs. tumour (GVT) effect, has been shown capable of debulking chemotherapy-resistant disease in both haematological and metastatic solid tumour settings. However, the use of this powerful mechanism has been limited by the severe and often lethal side-effect, called graft vs. host disease (GVHD), that is intimately coupled to, and necessary for, the GVT mechanism. A novel bioengineered allograft, called AlloStimTM, has been developed that is designed to elicit an autologous GVT effect without GVHD toxicity. The use of the “danger signals” of AlloStimTM to provide enhanced adjuvant effects to increase the effectiveness of cancer vaccines is discussed.

Dr Michael Har-Noy, CEO/CTO, Immunovative Therapies, Israel

17.05 Therapeutic vaccination to fight cancers and chronic infectious diseases: Phase II clinical trials using poxvirus MVA-based vaccines

It is becoming increasing clear that a number of immune mechanisms underlying the development of cancers and those associated with establishment of chronic infections are shared (e.g. presence and role of regulatory T-cells, T-cell inhibitory signals, epitope escape or epitope hiding). Therapeutic vaccines aiming at restoring and/or enhancing host’s effective immune responses are being actively developed in both fields and their use is moving into combination with standards-of-care. It is logical to believe that a given vaccine platform with its intrinsic specificities, if resulting in increased efficacy in one field (cancer) may hold promises in the other (chronic viral infection). We will discuss results from two phase II clinical trials that have tested the performance of MVA-derived vaccines in the treatment of metastatic Non Small Cell Lung Cancer (NSCLC) and Chronic Hepatitis C viral infection.

Dr Genevieve Inchauspe, Department Head, Infectious Diseases, Transgene, France

17.35 Proof of concept of therapeutic vaccine in the treatment of auto-immune disease: Anti-TNF in Crohn’s disease and anti-IFN in lupus

To find out more information about this presentation, please visit the conference website at www.informa-ls.com/immunotherapies

Dr Guy-Charles F. de La Horie, CEO, NeoVacs, France

18.05 Closing Remarks from the Chairperson and End of Day One

‘Immunotherapies & Cancer Vaccines 2012 provides a great opportunity to learn about the latest developments in the immunotherapy world from the people who are actually making it happen. Because it combines quality input and networking, this conference is not to be missed’ Dr Michael Hanna, Founder and Chairman, Vaccinogen, USA

PRE-CONFERENCE WORKSHOP: TUESDAY 4TH DECEMBER 2012 W

Clinical Trial Design: The Key to SuccessRegistration 08.30 – Start 09.00 – End 15.30 – Workshop material, refreshments and lunch will be provided

The recent success of therapies such as Ipilimumab and Sipuleucel have drawn investigators’ attention to the power of immunotherapy in the treatment of cancer. However, translating an idea to the clinic is fraught with difficulty. The purpose of this workshop will be to highlight some

of these challenges. • What constitutes cancer immunotherapy? • Translating immunotherapies• What should the preclinical package look like?

• How do we translate the idea into the clinic? • What constitutes success in the clinic?• How do we measure tumour response?• What is the most appropriate patient population?

Workshop leaders: Dr John Trizzino, CEO, ImmunoVaccine, Canada Dr David Edwards, Non-Clinical Safety Manager, Cancer Research UK, UK Dr Gary Wood, President & CEO, TVAX Biomedical, USA Dr Charles A. Nicolette, Chief Scientific Officer, Vice President, Research and Development, Argos Therapeutics, Inc., USA Dr Thomas Felzmann, CEO, Activartis Biotech GmbH, Germany

Feedback on the 2012 programme:

EVENING SEMINAR: WEDNESDAY 5TH DECEMBER 2012 X

Practical Advice on Successfully Filing IND ApplicationsRegistration 18.15 – Start 18.30 – Networking, Dinner and refreshments will be provided

Workshop leader: Dr Michael Covington, CMC Senior Director, Regulatory Affairs, Dendreon, USA

This interactive seminar provides the essential platform for industry professionals to understand how to best

overcome the major regulatory hurdles when submitting an IND proposal. This seminar will discuss:

What will be discussed?• Considerations for various disease targets• Key regulatory requirements- practical insight• Insight into preclinical data required

To Register Tel: +44 (0)20 7017 7481 Fax: +44 (0)20 7017 7823 Email: [email protected] Web: www.informa-ls.com/immunotherapies Please Quote: CQ3486

Essential regulatory insight

to achieve successful IND

applications

4 real-life case studies on designing the most effective

& successful immunotherapy

clinical trials

Upda

tes on

curre

ntly m

arke

ted

immu

nothe

rapie

s

Product at late

stage clinical phase

Free with a 4 day pass

Page 3: Informa Life Sciences’ Inaugural Immunotherapies & Cancer ... · Informa Life Sciences’ Inaugural Immunotherapies & Cancer Vaccines ... Immunotherapy is the premier biological

To Register Tel: +44 (0)20 7017 7481 Fax: +44 (0)20 7017 7823 Email: [email protected] Web: www.informa-ls.com/immunotherapies Please Quote: CQ3486

DAY TWO: THURSDAY 6 DECEMBER 201208.50 Chairperson’s Opening Remarks

Pre-Clinical Trial Assessment and Immune Modulation

KEYNOTE PRESENTATION09.00 Applications and understanding of Immunoscore Pre-existing antitumor immune responses (Immunoscore) predict better outcomes in patients with

a range of malignancies. Clinical trials must consider these parameters and stratify accordingly. It appears that current therapies fail in immunoscore negative patients. Understanding the mechanisms responsible for low immunoscore and identification of novel “non-tolerant” tumour targets may provide opportunities to induce immunity and improve outcomes.

Dr Bernard A. Fox, Chief, Molecular & Tumour Immunology, Robert W. Franz Cancer Research Centre, Earle A. Chiles Research Institute, Providence Cancer Centre, USA

09.30 Immunomodulatory strategies: approaches to reduce immunogenicity The immunogenicity of therapeutic proteins can have profound effects on their efficacy and could

cause adverse reactions. Understanding how to prevent or reverse this immunogenicity will be the focus of this presentation. Tolerance induction using IgG and Fc conjugated fusion proteins has been studied for over three decades. The basis of this tolerogenicity will be discussed, as well as deimmunisation approaches to immuno-modulation.

Professor David W. Scott, Vice Chair for Research Department of Medicine, Uniformed Services University of Health Sciences, USA

10.00 Case study: key updates on Janssen’s bapineuzumab programme This presentation will discuss the latest information of the bapineuzumab programme as well

as broader discussions on immunotherapy in neurodegeneration with the example of Abeta immunotherapies.

Dr Johannes Streffer, Senior Director, Neuroscience Development, Janssen – Pharmaceutical Companies of Johnson and Johnson, Belgium

10.30 Immune responses induced by AGS-003 predict clinical outcomes with statistically significant accuracy in metastatic renal cancer patients

We believe that the strategy behind immunotherapies designed to induce immunity against non-mutated self-antigens is fundamentally flawed since high avidity T cells reactive to them were eliminated during the process of negative selection, the central tolerance mechanism that protects against autoimmunity. This may be one reason why correlations between immunity to normal antigens and clinical outcomes have been elusive. In a phase 2 clinical study combining AGS-003, an immunotherapy targeting the entire autologous tumor antigen repertoire, with Sunitinib in newly diagnosed metastatic RCC patients we demonstrated a statistically significant correlation between the induction of anti-tumor memory T cells after 5 doses (15 weeks) and survival (r=.8, p<0.001) and an inverse correlation with tumor burden (r=-.6, p<0.019).

Dr Charles A. Nicolette, Chief Scientific Officer, Vice President, Research and Development, Argos Therapeutics, Inc., USA

11.00 Morning Coffee and Poster/Exhibition Viewing Time

11.30 Human immune system heterogeneity: impact on translating preclinical models to the clinic for immunotherapies

To find out more information about this presentation, please visit the conference website at www.informa-ls.com/immunotherapies

Dr William Grossman, Senior Vice President, Research & Development, Biothera, USA

12.00 Immunomodulators: Comparing the performance of different known immunomodulators

INTE

RAC

TIV

ED

ISC

USS

ION

PA

NEL • Overcoming the lack of systematically generated data, especially in humans

• How to best design an effective immunotherapy regimen Contributions from: Dr Charles A. Nicolette, Chief Scientific Officer, Vice President, Research and Development,

Argos Therapeutics, Inc., USA Plus other speakers of the day

12.30 Preclinical development of cancer vaccines: obstacle and hurdles This presentation will discuss the challenges and opportunities of efficacy models, as well as to

what extent safety needs to be monitored. Dr Emmanuelle Cornali, Head, Business Development, Aurigon Life Sciences, Germany

13.00 Lunch and partnering time

Designing Appropriate and Successful Clinical Trials

14.00 The changing regulatory landscape for immunotherapies & cancer vaccines The recent approvals of a vaccine to treat prostate cancer and an immune-modulatory antibody for

malignant melanoma have laid the foundation for the clinical subspecialty of immuno-oncology.

We have seen how R&D efforts had a dramatic impact on new regulation and can expect that the forming regulatory landscape will also influence the clinical development paths for future immune therapeutics. The lecture will give an overview on the changing regulatory landscape and its implications for development of new cancer immunotherapies.

Dr Cedrik M. Britten, Vice President R&D, Ribological GmbH, Germany

14.30 Cancer immunotherapy with recombinant poxviral vaccines BN ImmunoTherapeutics is developing poxvirus-based immunotherapies for the treatment

of cancer. The company’s lead program is PROSTVAC®, a therapeutic vaccine candidate for treatment of advanced prostate cancer that is the subject of an ongoing pivotal Phase 3 trial and is being developed under a collaboration agreement with the National Cancer Institute. Other product candidates in clinical development, which are based on the same platform technology, target breast, lung, ovarian and other cancers.

Dr Reiner Laus, President and Chief Executive Officer, BN ImmunoTherapeutics, USA

15.00 Immunotherapeutic strategies overcoming immunosuppression in the tumour microenvironment

Insufficient anti-tumour reactivity is due to the chronic inflammation represented by infiltrating leukocytes and soluble mediators leading to cancer progression. Using ret transgenic mouse melanoma model that mimics human melanoma, we demonstrated increased levels of chronic inflammatory factors and immunosuppressive cells in melanoma lesions correlated with tumor progression. Inhibitors of immunosuppressive tumour microenvironment induced anti-tumour effects and should be applied together with other melanoma immunotherapies.

Professor Viktor Umansky, German Cancer Research Center, Heidelberg and University Hospital Mannheim, Germany

15.30 Afternoon Tea and Poster/Exhibition Viewing Time

16.00 Identification of biomarkers predictive of clinical and immunological efficacy in cancer patients treated with TroVax (MVA-5T4)

Few immunotherapy compounds have demonstrated a clear link between the predicted mode of action of the product and clinical benefit. We have demonstrated that a 5T4-specific antibody response, induced by vaccination with TroVax, correlates with enhanced patient survival. Furthermore, we have identified a simple pre-treatment blood biomarker which predicts both immunological and clinical efficacy.

Dr Richard Harrop, Head, Clinical Analysis, Oxford Biomedica, UK

Delivery Systems for Administering Immunotherapies

16.30 A local immunotherapy approach for the treatment of peritoneal metastases of gynecological and gastrointestinal cancers

This presentation describes the clinical development of EGEN-001, a novel immunotherapeutic for local treatment of cancers that are metastasised to the peritoneal cavity. EGEN-001 is composed of an IL-12 plasmid and a novel lipopolymer delivery system and is designed to produce sustained local increases in IL-12 concentrations to stimulate the immune system against metastases without causing systemic toxicity.

Dr Khursheed Anwer, President and CSO, EGEN, Inc., USA

17.0 0 Rational design of targeted Synthetic Vaccine Particles (tSVP) for cancer Selecta Biosciences is a clinical stage company developing targeted Synthetic Vaccine Particles

(tSVP). A modular and self-assembling manufacturing process allows rapid optimisation of adjuvant/antigen combinations. The tSVP technology enables the use of potent adjuvants and efficient cross-presentation of antigen to cytolytic T cells. We have demonstrated potent in vivo CTL activity and therapeutic efficacy in animal models of cancer.

Dr Takashi Kei Kishimoto, Chief Scientific Officer, Selecta Biosciences, USA

17.30 Closing Remarks from the Chairperson and End of Conference

‘Immunotherapies & Cancer Vaccines 2012 provides a great opportunity to learn about the latest developments in the immunotherapy world from the people who are actually making it happen. Because it combines quality input and networking, this conference is not to be missed’ Dr Michael Hanna, Founder and Chairman, Vaccinogen, USA

To Register Tel: +44 (0)20 7017 7481 Fax: +44 (0)20 7017 7823 Email: [email protected] Web: www.informa-ls.com/immunotherapies Please Quote: CQ3486

POST-CONFERENCE WORKSHOP: FRIDAY 7TH DECEMBER 2012 Y

Antibodies: Targeted Therapy as an ImmunomodulatorRegistration 08.30 – Start 09.00 – End 15.30 – Workshop material, refreshments and lunch will be provided

There are a variety of different immunotherapy approaches that are being explored by industry and academia at present, however with antibodies being the most successful immunomodulator targeted therapy to date, this approach is what many companies are looking into closely. This interactive and case study led workshop explores current antibody immunotherapy products on the market, how they work, what led to their success and how this approach compares to other immunotherapy products.

Topics to be discussed:• Potential antibodies • How to determine one modality from another• Clinical settings applicable for antibody use • Comparisons to cytokine • Determining the best combination of antibodies

Workshop leaders: Dr Gary Starling, Director, Oncology Biologics, Abbott Biotherapeutics, USA & Dr Alan Korman, Vice President, Discovery Research, Bristol Myers Squibb, USA

SPONSORSHIP AND EXHIBITION OPPORTUNITIES AT THE VIC CONGRESS 2012

Informa’s Immunotherapies & Cancer Vaccines conference brings together key-decision makers from across regulatory, technical, research and strategic departments and is the ideal platform for showcasing your latest technologies and services.Reasons why you should choose this event:• 4 audiences for the price of 1: 1) Immunotherapies & Cancer Vaccines, 2) Vaccine Manufacturing, 3) Veterinary Vaccines and 4) Cell Therapy Manufacturing• Partner with 200+ senior level scientists at the VIC Congress with the authority to purchase new instruments, services and products.For further information on sponsorship & exhibitions opportunities, please contact: Ben Edwards: Tel: +44 (0) 20 7017 4447 Email: [email protected]

Leading experts from BMS and Abbott present on the success

of antibody immunotherapies

Product at late

stage clinical phase

Product at late

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Page 4: Informa Life Sciences’ Inaugural Immunotherapies & Cancer ... · Informa Life Sciences’ Inaugural Immunotherapies & Cancer Vaccines ... Immunotherapy is the premier biological

Immunotherapies & Cancer VaccinesWednesday 5 – Thursday 6 December 2012 Sheraton Brussels Hotel, Brussels, Belgium

www.informa-ls.com/immunotherapies

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Terms and ConditionsFEE: This includes all technical sessions, lunch and documentation.

CANCELLATIONS: Cancellations received in writing before and on Tuesday 20 November 2012 will be subject to a service charge of £99. The full conference fees remain payable after Tuesday 20 November 2012. Substitutions are welcome at any time. It may be necessary for reasons beyond the control of the organiser to alter the content and timing of the programme or the identity of the speakers. In the unfortunate event that an event is cancelled Informa are not liable for any costs incurred by delegates in connection with their attendance. This contract is subject to English Law.

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Conference Documentation: Cannot Attend? For those busy executives who cannot take full advantage of this event, the papers give you a useful record of the presentations made at the event. The set of speakers papers and/or slides from the conference is available after the event for £399 + 20% VAT. Contact Customer Services on tel: +44 (0) 20 7017 7481, fax: +44 (0) 20 7017 7823 or email: [email protected]

Are we mailing you correctly? To update your contact details on our database please email [email protected]

www.informa-ls.com/immunotherapies

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DELEGATE DETAILS – Please photocopy form for multiple bookings!

Conference CQ3486CPre-Conference Workshop CQ3486WPost-Conference Workshop CQ3486YEvening Seminar CQ3486X

Follow us @VICCongress, #Immunotherapies

Step 1. Select your workshops

The VAT rate is subject to change and may differ from the advertised rate.The amount you are charged will be determined when your invoice is raised.

Step 2. Select your pass

q Pre-conference Workshop W: Clinical Trial Design: The Key to Success q Post-conference Workshop Y: Antibodies: Targeted Therapy as an Immunomodulator

q Evening Seminar X: Practical Advice on Successfully Filing IND Applications

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Venue Details:

Sheraton Brussels Hotel Place Rogier 3, Brussels, 1210 · Belgium Phone: +32 2 2243111 Fax: +32 2 2243456 Web: www.sheratonbrussels.com

Reduced rate accommodation: the cost of accommodation is not included in the conference fee. In order to book reduced rate accommodation please visit the section “Accommodation” on the event website www.informa-ls.com/immunotherapies. Please book early to avoid disappointed (discounted rates at the Sheraton Brussels Hotel are available only until 3rd November 2012 and are subject to availability)

Pass Code Book Before

Friday 14th September 2012 Save

Book Between Friday 14th September and Friday 2nd November 2012

Save Book After

Friday 2nd November 2012Save

Academic /SME - 50% off full industry prices

2 Day Pass: Conference Only CQ3486C £1499 + VAT @ 21% = £1813.79 □ £200 £1599 + VAT @ 21% = £1934.79 □ £100 £1699 + VAT @ 21% = £2055.79 □ -£849.5 + VAT @ 21% =

£1027.89

2 Day Pass: Conference + Evening Seminar

CQ3486CX £1998 + VAT @ 21% =£2417.58 □ £200 £2098 + VAT @ 21% = £2538.58 □ £100 £2198 + VAT @ 21% = £2659.58 □ -£1099 + VAT @ 21% =

£1329.79

3 Day Pass: Conference + Pre or Post Conf Workshop

CQ3486CW/Y £2199+ VAT @ 21% = £2660.79 □ £200 £2299 + VAT @ 21% = £2781.79 □ £100 £2399 + VAT @ 21% = £2902.79 □ -£1199.5 + VAT @ 21% =

£1451.39

3 Day Pass: Conference + Pre or Post Conf Workshop + Evening Seminar

CQ3486CW/YX £2598 + VAT @ 21% = £3143.58 □ £300 £2698 + VAT @ 21% = £3264.58 □ £200 £2798 + VAT @ 21%= £3385.58 □ £100£1399 + VAT @ 21% =

£1692.79

FULL Pass: Conference + Pre & Post Conf Workshop + FREE Evening Seminar

CQ3486CWYX £2899 + VAT @ 21% = £3507.79 □ £700 £2999 + VAT @ 21% = £3628.79 □ £600 £3099 + VAT @ 21% =£3749.79 □ £500£1699 + VAT @ 21% =

£2055.79

Group Bookings: To take advantage of group bookings please contact Simon Lau, Tel: +44(0) 20 7017 7165e-mail: [email protected]

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Note
under this delegate details box, please insert a box with the following: To make payment by credit card: to ensure we provide the highest level of security for your credit card details we are unable to accept such payments via email or fax which ensures that these details are never stored on our network. To make payment by credit card on-line, please enter your credit card details in our secure payments website that you will use when making your booking via the event website (the event web address is near the top of the booking form). Alternatively call our customer service team on +44 (0) 20 7017 7481.