index of authors - Home | Biochemical Society Transactions · index of authors A Abe, K ... Barron, R.M. 1155 Bastide, M. 1341 Bazan, N.G. 1277 Belandia, B. 1124 Belﬁeld, E.J. 1223

indexof

authorsAAbe, K. 1310Abraham, S.M. 1018Alcaro, L. 1228Alexander, S.P.H. 1095Al-Gazzar, A. 1246Amato, E. 1228Arnaoutakis, K. 1141Arthur, J.S.C. 1107Attrill, H. 1024Avril, T. 1024

BBaird, A.E. 1313Balding, P.R. 1178Bancos, S. 1199Barron, R.M. 1155Bastide, M. 1341Bazan, N.G. 1277Belandia, B. 1124Belfield, E.J. 1223Bennett, A.J. 1095Bernhardt, R. 1215Bevan, C.L. 1124Bingham, A.J. 1138Bishop, G. 1199Bishop, M.T. 1155Bode, M. 1241Bohlmann, J. 1209Bonecchi, R. 1014Bordet, R. 1341Borroni, E.M. 1014Bose, D. 1067Brooke, G.N. 1124Buchan, A.M. 1318Buck, M. 1067Buracchi, C. 1014Burrows, P. 1067Busby, S.J.W. 1075

CCallewaert, L. 1089Cancellotti, E. 1155Cannon, W. 1067Carswell, H.V. 1362Casey, R. 1223Castle, J. 1199Catterall, W.A. 1299Cesaro, L. 1303Chamorro, A. 1267Chan, P.H. 1283, 1366Chinetti, G. 1128Chotai, D. 1124Christian, M. 1103Chun, Y.-J. 1183Claessens, F. 1089Clark, A.R. 1018Collins, H.F. 1173Cook, P.R. 1133Cools, H.J. 1219Corsi, I. 1228Cramer, P. 1058Crandall, T. 1366Crocker, P.R. 1024Culmsee, C. 1334Cummins, C.L. 1110

DDart, D.A. 1124Davies, P. 1098Dawson, T.M. 1307Dawson, V.L. 1307Deguchi, K. 1310Della Torre, C. 1228del Zoppo, G.J. 1261Deng, W. 1051Deplanque, D. 1341Doddapaneni, H. 1165Dolton, G.M. 1041Duff, J. 1098Dunford, A.J. 1178Duriez, P. 1341

EEhlting, J. 1192Endo, H. 1283

FFaro-Trindade, I. 1133Feyereisen, R. 1252Fisher, M. 1271Focardi, S. 1228Foka, P. 1141Fraaije, B.A. 1219Frebel, K. 1287Fruchart, J.C. 1128, 1341

GGagnon-Kugler, T. 1079Galliera, E. 1014Gamble, S.C. 1124Gartland, K.M.A. 1151Gautier, S. 1341Geiduschek, E.P. 1082Gele, P. 1341Gilbert, L.I. 1256Ginsberg, M.D. 1323Girvan, H.M. 1173, 1178Glawischnig, E. 1206Good, L. 1148Gorina, R. 1267Graham, G.J. 1002Graham, S.V. 1145Griffiths, W.J. 1246Guengerich, F.P. 1183Gustafsson, J.-Å. 1114Gwyer, E. 1032

HHaelens, A. 1089Hallenbeck, J.M. 1295Hamberger, B. 1209Hannemann, F. 1215Hansell, C.A.H. 1009Hargrove, T.Y. 1161Harrison, K. 1199Hart, P. 1155Herrmann, O. 1291Hill, M.D. 1323Hsieh, L. 1366Hsu, J.-Y. 1047Hughes, R.K. 1223Hung, S. 1261Hussell, T. 1032

IInta, I. 1291Irvine, S.A. 1141

JJoly, N. 1067Joussen, N. 1241Jungmann, V. 1236Juven-Gershon, T. 1047

KKaderbhai, M.A. 1231Kaderbhai, N.N. 1231Kadonaga, J.T. 1047Kamiya, T. 1310Kamiya, Y. 1199Kassavetis, G.A. 1082Kelly, D.E. 1159Kelly, S.L. 1159, 1231Kendall, D.A. 1095Kim, S.H. 1219Klumpp, S. 1370Koziol, J.A. 1261Krieglstein, J. 1370Kushiro, T. 1199

LLamb, D.C. 1159Landick, R. 1062Lane, C. 1246Langlois, F. 1079Laprais, M. 1341Lavery, D.N. 1054Lee, Y.-J. 1295Lepesheva, G.I. 1161Leys, D. 1173, 1178Lightman, S.L. 1117Lisurek, M. 1215Locati, M. 1014Lu, C.-Z. 1327Lucas, J.A. 1219Lukiw, W.J. 1277

MMabuchi, T. 1261Macrae, I.M. 1362Maier, C.M. 1366Mangelsdorf, D.J. 1110Manson, J.C. 1155Mantovani, A. 1014Marshall, K.R. 1178Martinez de la Torre, Y. 1014Matthews, R.J. 1041McEwan, I.J. 1054, 1098McKimmie, C.S. 1002McLean, K.J. 1173, 1178McPhillips, M.G. 1145Meggio, F. 1303Milner, R. 1261Miroslavova, N.S. 1075Mitchell, J.E. 1075Mizutani, M. 1202Moehren, U. 1089Mole, S. 1145Molnar, I. 1236Montoya, T. 1199Morikawa, T. 1202Moss, T. 1079

Munro, A.W. 1173, 1178Murray, P.J. 1028

NNarasimhan, P. 1366Neeli, R. 1173, 1178Nes, W.D. 1161Nibbs, R.J.B. 1009Niquet, J. 1347Nomura, T. 1199

OOhta, D. 1202Okano, H. 1310Ooi, L. 1138Ortiz de Montellano, P.R. 1170Ott, R.D. 1161Ouk, T. 1341

PPachlatko, J.P. 1236Pagano, M.A. 1303Palesch, Y.Y. 1323Pandey, A.V. 1186Papadakis, M. 1318Pape, T. 1067Parker, M.G. 1103Pavlov, V.A. 1037Petrault, O. 1341Pinna, L.A. 1303Planas, A.M. 1267Plesnila, N. 1334Powell, S.M. 1124Proost, P. 997Provart, N.J. 1192Pruenster, M. 1005

RRamji, D.P. 1141Raper, A. 1024Rappas, M. 1067Reebye, V. 1124Rewitz, K.F. 1256Roberts, S.G.E. 1051Rot, A. 1005Rybczynski, R. 1256

SSabri, M. 1178Saito, A. 1283Sathish, J.G. 1041Sawamoto, K. 1310Schabitz, W.-R. 1271Scheuer, T. 1299Schmidt, B. 1241Schuklenk, U. 1151Schumacher, J. 1067Schuphan, I. 1241Schwaninger, M. 1291Scrutton, N.S. 1173Seibert, C. 1246Seo, D.-W. 1347Seward, H.E. 1178Sharif, A. 1246Shimada, T. 1183Simgen, B. 1215Simon, R. 1356Simpson, C.V. 1009

Volume 34 Part 6 C© 2006 Biochemical Society ix

Singh, N.N. 1141Snelgrove, R. 1032Staels, B. 1128, 1341Stefanovsky, V. 1079Stege, J. 1236Stenzel-Poore, M.P. 1352Stevens, S.L. 1352Struyf, S. 997Subramanian, V. 1165Sun, Y. 1095Szatmari, A.-M. 1199Szekeres, M. 1199

TTanner, T. 1089Tebbutt, J. 1075

Thissen, M.-C. 1370Thomas, C.M. 1072Timmons, J.A. 1148Tracey, K.J. 1037Trefzer, A. 1236

VVan Damme, J. 997Vecchi, A. 1014Veerapraditsin, T. 1145Verras, A. 1170Verrijdt, G. 1089Virus, C. 1215

WWada-Hiraike, O. 1114

Waltham, T.N. 1173Wang, X. 1261Wang, Y. 1246Warner, M. 1114Warren, J.T. 1256Wasterlain, C.G. 1347Waterman, M.R. 1161, 1183Watt, K. 1098Werck-Reichhart, D. 1192Whitaker, H.C. 1124White, R. 1103Wiese, S. 1287Wigneshweraraj, S. 1067Wingate, A.D. 1107Wood, I.C. 1138Wright, M.C. 1119

XXiao, B.-G. 1327Xiong, Z. 1356

YYadav, J.S. 1165Yamaguchi, S. 1199Yamashita, T. 1310Yokota, T. 1199

ZZhang, J. 1024Zhang, X. 1067

x Volume 34 Part 6 C© 2006 Biochemical Society

authorindex

Abe, K. 1310Abraham, S.M. 1018Alcaro, L. 1228Alexander, S.P.H. 1095Al-Gazzar, A. 1246Amato, E. 1228Arnaoutakis, K. 1141Arthur, J.S.C. 1107Attrill, H. 1024Avril, T. 1024

Baird, A.E. 1313Balding, P.R. 1178Bancos, S. 1199Barron, R.M. 1155Bastide, M. 1341Bazan, N.G. 1277Belandia, B. 1124Belfield, E.J. 1223Bennett, A.J. 1095Bernhardt, R. 1215Bevan, C.L. 1124Bingham, A.J. 1138Bishop, G. 1199Bishop, M.T. 1155Bode, M. 1241Bohlmann, J. 1209Bonecchi, R. 1014Bordet, R. 1341Borroni, E.M. 1014Bose, D. 1067Brooke, G.N. 1124Buchan, A.M. 1318Buck, M. 1067Buracchi, C. 1014Burrows, P. 1067Busby, S.J.W. 1075

Callewaert, L. 1089Cancellotti, E. 1155Cannon, W. 1067Carswell, H.V. 1362Casey, R. 1223Castle, J. 1199Catterall, W.A. 1299Cesaro, L. 1303Chamorro, A. 1267Chan, P.H. 1283, 1366Chinetti, G. 1128Chotai, D. 1124Christian, M. 1103Chun, Y.-J. 1183Claessens, F. 1089Clark, A.R. 1018Collins, H.F. 1173Cook, P.R. 1133Cools, H.J. 1219Corsi, I. 1228Cramer, P. 1058Crandall, T. 1366Crocker, P.R. 1024Culmsee, C. 1334Cummins, C.L. 1110

Dart, D.A. 1124Davies, P. 1098Dawson, T.M. 1307Dawson, V.L. 1307

Deguchi, K. 1310Della Torre, C. 1228del Zoppo, G.J. 1261Deng, W. 1051Deplanque, D. 1341Doddapaneni, H. 1165Dolton, G.M. 1041Duff, J. 1098Dunford, A.J. 1178Duriez, P. 1341

Ehlting, J. 1192Endo, H. 1283

Faro-Trindade, I. 1133Feyereisen, R. 1252Fisher, M. 1271Focardi, S. 1228Foka, P. 1141Fraaije, B.A. 1219Frebel, K. 1287Fruchart, J.C. 1128, 1341

Gagnon-Kugler, T. 1079Galliera, E. 1014Gamble, S.C. 1124Gartland, K.M.A. 1151Gautier, S. 1341Geiduschek, E.P. 1082Gele, P. 1341Gilbert, L.I. 1256Ginsberg, M.D. 1323Girvan, H.M. 1173, 1178Glawischnig, E. 1206Good, L. 1148Gorina, R. 1267Graham, G.J. 1002Graham, S.V. 1145Griffiths, W.J. 1246Guengerich, F.P. 1183Gustafsson, J.-Å. 1114Gwyer, E. 1032

Haelens, A. 1089Hallenbeck, J.M. 1295Hamberger, B. 1209Hannemann, F. 1215Hansell, C.A.H. 1009Hargrove, T.Y. 1161Harrison, K. 1199Hart, P. 1155Herrmann, O. 1291Hill, M.D. 1323Hsieh, L. 1366Hsu, J.-Y. 1047Hughes, R.K. 1223Hung, S. 1261Hussell, T. 1032

Inta, I. 1291Irvine, S.A. 1141

Joly, N. 1067Joussen, N. 1241Jungmann, V. 1236Juven-Gershon, T. 1047

Kaderbhai, M.A. 1231

Kaderbhai, N.N. 1231Kadonaga, J.T. 1047Kamiya, T. 1310Kamiya, Y. 1199Kassavetis, G.A. 1082Kelly, D.E. 1159Kelly, S.L. 1159, 1231Kendall, D.A. 1095Kim, S.H. 1219Klumpp, S. 1370Koziol, J.A. 1261Krieglstein, J. 1370Kushiro, T. 1199

Lamb, D.C. 1159Landick, R. 1062Lane, C. 1246Langlois, F. 1079Laprais, M. 1341Lavery, D.N. 1054Lee, Y.-J. 1295Lepesheva, G.I. 1161Leys, D. 1173, 1178Lightman, S.L. 1117Lisurek, M. 1215Locati, M. 1014Lu, C.-Z. 1327Lucas, J.A. 1219Lukiw, W.J. 1277

Mabuchi, T. 1261Macrae, I.M. 1362Maier, C.M. 1366Mangelsdorf, D.J. 1110Manson, J.C. 1155Mantovani, A. 1014Marshall, K.R. 1178Martinez de la Torre, Y. 1014Matthews, R.J. 1041McEwan, I.J. 1054, 1098McKimmie, C.S. 1002McLean, K.J. 1173, 1178McPhillips, M.G. 1145Meggio, F. 1303Milner, R. 1261Miroslavova, N.S. 1075Mitchell, J.E. 1075Mizutani, M. 1202Moehren, U. 1089Mole, S. 1145Molnar, I. 1236Montoya, T. 1199Morikawa, T. 1202Moss, T. 1079Munro, A.W. 1173, 1178Murray, P.J. 1028

Narasimhan, P. 1366Neeli, R. 1173, 1178Nes, W.D. 1161Nibbs, R.J.B. 1009Niquet, J. 1347Nomura, T. 1199

Ohta, D. 1202Okano, H. 1310Ooi, L. 1138Ortiz de Montellano, P.R. 1170

C©2006 Biochemical Society 1

2 Biochemical Society Transactions (2006) Volume 34, part 6

Ott, R.D. 1161Ouk, T. 1341

Pachlatko, J.P. 1236Pagano, M.A. 1303Palesch, Y.Y. 1323Pandey, A.V. 1186Papadakis, M. 1318Pape, T. 1067Parker, M.G. 1103Pavlov, V.A. 1037Petrault, O. 1341Pinna, L.A. 1303Planas, A.M. 1267Plesnila, N. 1334Powell, S.M. 1124Proost, P. 997Provart, N.J. 1192Pruenster, M. 1005

Ramji, D.P. 1141Raper, A. 1024Rappas, M. 1067Reebye, V. 1124Rewitz, K.F. 1256Roberts, S.G.E. 1051Rot, A. 1005Rybczynski, R. 1256

Sabri, M. 1178Saito, A. 1283Sathish, J.G. 1041Sawamoto, K. 1310Schabitz, W.-R. 1271Scheuer, T. 1299

Schmidt, B. 1241Schuklenk, U. 1151Schumacher, J. 1067Schuphan, I. 1241Schwaninger, M. 1291Scrutton, N.S. 1173Seibert, C. 1246Seo, D.-W. 1347Seward, H.E. 1178Sharif, A. 1246Shimada, T. 1183Simgen, B. 1215Simon, R. 1356Simpson, C.V. 1009Singh, N.N. 1141Snelgrove, R. 1032Staels, B. 1128, 1341Stefanovsky, V. 1079Stege, J. 1236Stenzel-Poore, M.P. 1352Stevens, S.L. 1352Struyf, S. 997Subramanian, V. 1165Sun, Y. 1095Szatmari, A.-M. 1199Szekeres, M. 1199

Tanner, T. 1089Tebbutt, J. 1075Thissen, M.-C. 1370Thomas, C.M. 1072Timmons, J.A. 1148Tracey, K.J. 1037Trefzer, A. 1236

Van Damme, J. 997Vecchi, A. 1014Veerapraditsin, T. 1145Verras, A. 1170Verrijdt, G. 1089Virus, C. 1215

Wada-Hiraike, O. 1114Waltham, T.N. 1173Wang, X. 1261Wang, Y. 1246Warner, M. 1114Warren, J.T. 1256Wasterlain, C.G. 1347Waterman, M.R. 1161, 1183Watt, K. 1098Werck-Reichhart, D. 1192Whitaker, H.C. 1124White, R. 1103Wiese, S. 1287Wigneshweraraj, S. 1067Wingate, A.D. 1107Wood, I.C. 1138Wright, M.C. 1119

Xiao, B.-G. 1327Xiong, Z. 1356

Yadav, J.S. 1165Yamaguchi, S. 1199Yamashita, T. 1310Yokota, T. 1199

Zhang, J. 1024Zhang, X. 1067

C©2006 Biochemical Society

subjectindex

Aacidotoxicity, 1356acid-sensing ion channel (ASIC), 1356action potential, 1299activation of transcription, 1075adipocyte, 1103adrenal gland, 1110Akt, 1295albumin, 1323allene oxide synthase (AOS), 1192, 1223Alzheimer’s disease, 1277amyloid β-peptide (Aβ), 1277androgen receptor, 1089, 1124angiogenesis, 1327anti-androgen, 1124anti-apoptosis, 1327antigen-presenting cell, 1032anti-inflammatory cytokine, 1267apolipoprotein E, 1141apoptosis, 1114, 1283, 1287, 1303, 1370apoptosis inducing factor (AIF), 1334,

1347Arabidopsis, 1192, 1199, 1206atherosclerosis, 1141ATPase associated with various cellular

activities activator (AAA+ activator),1067

ATP hydrolysis, 1067atrial natriuretic peptide, 1138atypical chemokine receptor, 1009autoimmune disease, 1041autoimmunity, 1032avermectin, 1236azole binding, 1170, 1178

BBacillus, 1173bacterial cytochrome P450, 1215bacterial enhancer binding protein, 1067bacterium, 1072basal transcription factor, 1054Bcl-2-associated athanogene 1 (Bag1),

1287Bdp1, 1082bicalutamide, 1124Bid, 1334biocatalysis, 1236biodiversity, 1148, 1161biomarker, 1159biotransformation, 1231bird flu, 1151blood–brain barrier, 1261, 1366blood genomic profiling, 1313BM3, 1173bovine spongiform encephalopathy (BSE),

1155brain, 1307brain injury, 1366brain ischaemia, 1356brain natriuretic peptide, 1138brassicasterol, 1202brassinolide, 1199brassinosteroid, 1199Brf1, 1082budding yeast, 1082

Ccalcium, 1356

camalexin, 1206cAMP receptor protein (CRP), 1075cancer, 1114cannabinoid receptor (CB receptor), 1095cardiac hypertrophy, 1138caspase, 1334, 1347catalytic activity, 1161catenin, 1114CC chemokine, 1002CC chemokine receptor (CCR), 1014CD45, 1041cell differentiation, 1133cell survival, 1107cellular proliferation, 1114central nervous system (CNS), 1095cerebral ischaemia, 1291, 1310, 1327,

1341, 1362, 1366chemoattractant, 1014chemokine, 997, 1005chemokine sequestration, 1009chemotaxis, 997cholesterol, 1110, 1128cholesterol homoeostasis, 1141cholinergic anti-inflammatory pathway,

1037chromatin, 1138chromatin loop, 1133chromatin remodelling, 1103chronic wasting disease (CWD), 1155cis-acting RNA element, 1145clinical trial, 1271co-expression analysis, 1192colonic epithelium, 1114conformational mobility, 1170conifer, 1209core promoter, 1051corticosterone, 1110, 1117co-stimulation, 1032Creutzfeldt–Jakob disease (CJD), 1155crystal structure, 1051, 1089cytochrome b5, 1231cytochrome c, 1186, 1283, 1334cytochrome P450 (CYP/P450), 1159, 1161,

1165, 1170, 1173, 1178, 1183, 1186,1192, 1199, 1202, 1209, 1215, 1219,1223, 1228, 1231, 1236, 1241, 1246,1252, 1256

cytochrome P450 1A (CYP1A), 1228cytochrome P450 51 (CYP51), 1161, 1219cytochrome P450 63 (CYP63), 1165cytochrome P450 subfamily 74 (CYP74),

1223cytochrome P450 79B2 (CYP79B2), 1206cytochrome P450 85 clan (CYP85), 1209cytochrome P450 101 (CYP101), 1170cytochrome P450 102 (CYP102), 1173cytochrome P450 121 (CYP121), 1178cytochrome P450 710A (CYP710A), 1202cytochrome P450 106A2 (CYP106A2), 1215cytochrome P450 reductase, 1186cytokine, 1018cytoprotection, 1295cytosolic phospholipase A2, 1277

DD6, 1002, 1009decoy receptor, 1014depolarization, 1299

detergent micelle, 1223dihydrotestosterone, 1098dimerization, 1089directed evolution, 1215diterpene resin acid (DRA), 1209DNA binding, 1089DNA opening, 1067docosahexaenoic acid (DHA), 1277downstream core promoter element (DPE),

1047Drosophila melanogaster, 1252druggable kinome, 1303drug metabolism, 1186dual-specificity phosphatase (DUSP), 1018Duffy antigen, 1005, 1014Duffy antigen receptor for chemokines

(DARC), 1009dwarfism, 1199dystroglycan, 1261

Eecdysone, 1256electron transfer, 1173electron transport, 1183emamectin benzoate, 1236endocytosis, 1024endothelial cell, 1005, 1366, 1370epigenetics, 1148epithelial differentiation, 1145erythrocyte, 1005Escherichia coli, 1183, 12317-ethoxyresorufin-O-de-ethylase (EROD),

1228European eel [Anguilla anguilla (Linnaeus,

1758)], 1228evolution, 1252excitotoxicity, 1307extracellular matrix, 1261

Ffatty acid, 1370ferredoxin, 1183, 1236ferredoxin reductase, 1183fibrosis, 1119flavocytochrome, 1173Fn14, 1291focal cerebral ischaemia, 1323focal ischaemia, 1261fungicide, 1219

Ggene expression, 1138, 1141gene expression profiling, 1313gene reassembly, 1236gene regulation, 1062genome organization, 1133global cerebral ischaemia, 1283glucocorticoid, 1018, 1117glutamate, 1356G-protein-coupled receptor (GPCR), 1095granulocyte colony-stimulating factor

(GCSF), 1327growth factor, 1079

Hhaem, 1173, 1178, 1223haemopoietic stem cell, 1327haemoprotein, 1231


4 Biochemical Society Transactions (2006) Volume 34, part 6

Halloween gene, 1256health policy, 1151Hey1, 1124hibernation, 1295histone methyltransferase, 1058HIV, 997horizontal gene transfer, 1165hormone replacement therapy, 1362human androgen receptor, 1098human papillomavirus type 16 (HPV-16),

1145hydroperoxide lyase, 122320-hydroxyecdysone, 1256hypoxia/ischaemia, 1347

Iimidazole, 1170immune pathology, 1032immune response, 1002, 1009, 1028immune system, 1267immunoglobulin (Ig) superfamily, 1024imprinting, 1148inflammation, 997, 1002, 1014, 1018,

1028, 1037, 1119influenza, 1151inhibitory κB (IκB) kinase (IKK), 1291inhibitory receptor, 1032initiator (Inr), 1047injury, 1356innate immune response, 1018innate immune system, 1024insect genome, 1252integrin, 1261interceptor, 1005interleukin-6, 1310interleukin-10 (IL-10), 1028intracerebral haemorrhage, 1318ischaemia, 1267, 1295, 1307ischaemic injury, 1352ischaemic stroke, 1313

JJanus kinase/signal transducer and

activator of transcription pathway(JAK/STAT pathway), 1267

Kkinase inhibitor, 1303kinetic analysis, 1075

Lleucocyte, 1002, 1009, 1014, 1024, 1313leucocyte trafficking, 1005ligand-binding domain, 1098lipid metabolism, 1110lipopolysaccharide (LPS), 1352lipoprotein, 1370lipoprotein lipase (LPL), 1141liquid chromatography–MS, 1246liver, 1119liver X receptor (LXR), 1110, 1128lymphatic endothelium, 1002Lyp, 1041

Mmacrophage, 1028, 1128mammalian cell, 1079

matrix adhesion receptor, 1261metabolic pathway, 1192metabolism, 1103middle cerebral artery occlusion, 1095,

1362mitochondrion, 1252, 1283, 1334, 1347mitogen-activated protein kinase (MAPK),

1018molten globule, 1054motif ten element (MTE), 1047moulting, 1256muscarinic receptor, 1037Mycobacterium tuberculosis, 1178

NNADPH cytochrome c reductase, 1228natural antisense, 1148neurodegenerative disease, 1341neuronal differentiation, 1287neuronal necrosis, 1347neuronal survival, 1277, 1287neuroprotection, 1095, 1271, 1310, 1318,

1323, 1327, 1341, 1352neuroprotective drug, 1271neurotrophic factor, 1310neurotrophin, 1287neurovascular imaging, 1318α7 nicotinic acetylcholine receptor, 1037non-coding RNA, 1148nuclear factor κB (NF-κB), 1291nuclear orphan receptor, 1107nuclear receptor, 1089, 1103, 1110, 1341nuclear receptor signalling, 1117nucleotide addition cycle, 1062Nur77, 1107

Ooestrogen, 1362oestrogen receptor β (ERβ), 1114oligaemia, 1295one-dimensional gel electrophoresis, 1246OX40, 1032oxidative metabolic profiling, 1241oxidative stress, 1366oxidized metabolite, 1241oxylipin, 1223

Pp53, 1283pad3, 1206pandemic, 1151partitioning, 1072pausing, 1062peripheral blood, 1313peroxisome-proliferator-activated receptor

(PPAR), 1095, 1341peroxisome-proliferator-activated receptor

α (PPARα), 1128peroxisome-proliferator-activated receptor

γ co-activator-1α (PGC-1α), 1103P450 classification, 1159P450foxy, 1165P450ome, 1165Phanerochaete chrysosporium, 1165phenobarbital, 1252phosphoproteome, 1303phosphorylation, 1107, 1299

phytoalexin, 1206phytohormone, 1209pifithrin-α, 1283plant, 1202plant pathogen, 1219plant steroid hormone, 1199plasmacytoid dendritic cell, 1024plasmid maintenance, 1072plasmid replication, 1072plasmid transfer, 1072polymorphism, 1186post-translational control, 1107post-translational modification, 997preconditioning, 1307pregnane X receptor (PXR), 1119pre-initiation complex, 1051prion protein (PrP), 1155programmed cell death, 1334prostate cancer, 1098prostate cancer therapy, 1124protease, 997protein–protein interaction, 1054protein kinase A (PKA), 1299protein kinase CK2, 1303protein phosphatase type 2C, 1370protein tyrosine phosphatase, 1041proteomics, 1246prothoracic gland, 1256

Rrandomized clinical trial, 1323Ras-activated factor kinase (Raf kinase),

1287receptor-interacting protein 140 (RIP140),

1103recruitment, 1075redox system, 1178reperfusion, 1366repressor element 1-silencing transcription

factor (REST), 1138ribosomal RNA gene, 1079rifampicin, 1119RNA polymerase, 1058, 1062, 1067, 1075,

1133RNA polymerase I, 1079RNA polymerase II, 1047, 1051RNA polymerase III, 1082RNA processing, 1145root-specific gene, 1192rRNA, 1079

Sscaffold, 1310scrapie, 1155sepsis, 1028serine- and arginine-rich protein

(SR protein), 1145Set2 Rpb1-interacting domain

(SRI domain), 1058severe acute respiratory syndrome (SARS),

1151sialic acid, 1024σ 54 factor, 1067signal transducer and activator of

transcription 3 (STAT3), 1028small ubiquitin-related modifier (SUMO),

1295sodium channel, 1299


Biochemical Society Transactions (2006) Volume 34, part 6 5

soluble amyloid precursor protein (sAPPα),1277

spinal bulbar muscular atrophy, 1098Src homology 2 domain-containing protein

tyrosine phosphatase 1 (SHP-1), 1041status epilepticus, 1347steroid, 1215steroid hormone receptor, 1054sterol 14α-demethylase, 1161sterol �22-desaturase, 1159, 1202stigmasterol, 1202Streptomyces coelicolor, 1183stroke, 1267, 1271, 1291, 1307, 1323,

1362substrate preference, 1161subventricular zone, 1310suppressor of cytokine signalling (SOCS),

1267

Ttandem MS, 1246TATA box, 1047, 1051TATA-box-binding protein (TBP), 1082T-cell receptor (TCR), 1041terpenoid, 1209therapeutic strategy, 1313

thermophilic haemoprotein, 1170thiazolidinedione, 1341thrombolysis, 1271, 1318, 1323tissue plasminogen activator (tPA), 1318tobacco cell suspension culture, 1241tolerance, 1352Toll-like receptor (TLR), 1352trafficking, 1128transactivation domain, 1054, 1098transcript elongation, 1062transcription, 1054, 1062, 1072, 1075,

1089, 1148transcriptional regulation, 1128transcription elongation, 1079transcription factor IIB (TFIIB), 1047, 1051transcription factory, 1133transcription initiation factor, 1082transforming growth factor-β (TGF-β),

1119, 1141transgenic plant tissue, 1241transmissible spongiform encephalopathy

(TSE), 1155trial development, 1271triazole, 12192,4,6-trinitrotoluene (TNT), 1228trypanosome, 1161

tumour necrosis factor (TNF), 1037, 1352tumour necrosis factor (TNF)-like weak

inducer of apoptosis (TWEAK), 1291tyrosine kinase, 1299

UUDP-glucuronosyltransferase, 1228ultradian rhythm, 1117

Vvagus nerve, 1037virus, 1151

Wwhole-cell biocatalysis, 1215

Xxenobiotic, 1231xenobiotic metabolism, 1159, 1241X-ray crystallography, 1058

Yyeast, 1058


authorindex

Abderrahmani, A. 696Abe, K. 1310Abi-Gerges, A. 484Abraham, S.M. 1018Abramsson, A. 454Adelroth, P. 188Al-Gazzar, A. 1246Alcaro, L. 1228Alexander, S.P.H. 1095Allen, J.W.A. 91, 150Allen, S.J. 587Alpy, F. 343Amato, E. 1228Amrani, N. 39An, R. 791Andersen, G.R. 1Anderson, K.E. 647Anilkumar, N. 960Anthony, T.G. 7Aoki, K. 851Archer, I. 287Ardley, H.C. 743Armsen, W. 55Armstrong, S.J. 542Arnal, J.-F. 17Arnaoutakis, K. 1141Arthur, J.S.C. 1107Ashcroft, F.M. 243, 806Attrill, H. 1024Augustine, G.J. 68Auton, A. 526Avril, T. 1024Awai, K. 395

Babiychuk, E.B. 374Bagshaw, C.R. 979Bailey, M. 557Baillie, G.S. 474, 504Baird, A.E. 1313Baird, D.M. 581Balding, P.R. 1178Bancos, S. 1199Bankaitis, V.A. 346Barber, J. 619Bardwell, L. 837Barran, P.E. 257Barron, R.M. 1155Barrow, S.L. 381Basaglia, M. 130Bastide, M. 1341Baumann, N.A. 356Baur, R. 868Bayard, F. 17Bayes, J.J. 569Bazan, N.G. 1277Bedmar, E.J. 108, 195Beh, C.T. 356Belandia, B. 1124Belfield, E.J. 1223Belfield, G.P. 313Bender, K. 811Bennett, A.J. 1095Benning, C. 395Berenguer, J. 97Bernhardt, R. 1215Berridge, M.J. 228Betsholtz, C. 454Betz, H. 45, 55

Bevan, C.L. 1124Bevins, C.L. 263Billiar, T.R. 957Bingham, A.J. 1138Bishop, G. 1199Bishop, M.T. 1155Blasco, R. 152Bode, M. 1241Boespflug-Tanguy, O. 22Bohlmann, J. 1209Bonecchi, R. 1014Bonete, M.J. 115Bonnard, N. 108Boone, A.N. 223Bordet, R. 1341Borroni, E.M. 1014Borutaite, V. 953Bose, D. 1067Bothe, H. 169Bottolo, L. 526Boulineau, N. 868Boulton, S.J. 633Bouyoucef-Cherchalli, D. 846Brady, L. 587Bramham, C.R. 600Brandner, B. 435Braun, A. 591, 594Brennan, L. 811Briscoe, C.A. 770Britt-Compton, B. 581Broadie, K. 81Brockie, P.J. 64Brooke, G.N. 1124Brown, A.J. 770Brown, G.C. 953Brownsey, R.W. 223Brunori, M. 185Buchan, A.M. 1318Buck, M. 1067Bukoreshtliev, N.V. 671Buracchi, C. 1014Burlat, B. 143Burrows, J.F. 764Burrows, P. 1067Busby, S.J.W. 1075Bushell, M. 12Busquet, P. 903Butler, C.S. 118, 122Butt, J.N. 115, 133, 143Borner, G.V. 554Busch, A. 182

Cabello, P. 127Cabezas, A. 174Cabon, F. 17Callewaert, L. 1089Campopiano, D.J. 251Cancellotti, E. 1155Cannon, W. 1067Carland, J.E. 882Carr, R. 287Carswell, H.V. 1362Casella, S. 130Casey, R. 1223Castillo, F. 127, 152Castle, J. 1199Cattaneo, A. 605Catterall, W.A. 1299

Cava, F. 97Cavey, J.R. 735Cesaro, L. 1303Chamorro, A. 1267Chan, C.B. 802Chan, P.H. 1283, 1366Chantry, A. 761Chao, M.V. 607Chee, F. 88Cherny, D. 979Chin, J.W. 328Chinetti, G. 1128Choi, J.-Y. 404Chotai, D. 1124Christian, M. 1103Chun, Y.-J. 1183Cid, L.P. 899Claessens, F. 1089Clague, M.J. 754Clark, A.R. 1018Clarke, D.J. 251Clarke, D.T. 427Clarke, T.A. 143Cole, J.A. 104, 111, 122, 143Collins, H.F. 1173Connolly, C.N. 863Constantinidou, C. 104Cook, P.R. 1133Cools, H.J. 1219Cooper, D.M.F. 468, 480Cooper, M.A. 882Corsi, I. 1228Cortes-Lorenzo, C. 165Coussen, F. 927Covaceuszach, S. 605Covington, D.K. 770Cox, R.D. 806Cramer, P. 1058Cramm, R. 182Crandall, T. 1366Crocker, P.R. 1024Cullen, P.J. 846Culmsee, C. 1334Cummins, C.L. 1110Cutruzzola, F. 185Cuttle, M. 88Cuzzocrea, S. 965

Damilano, F. 502Dart, D.A. 1124da Silva Xavier, G. 791Dasso, M. 711D’Autreaux, B. 191Davidson, K. 647Davies, A. 894Davies, P. 1098Davies, S.-A. 512Davison, E.J. 743Dawbarn, D. 587Dawson, T.M. 1307Dawson, V.L. 1307Day, A.J. 446Day, J.P. 512de Andrade, P.B.M. 824Dedos, S.G. 515Deeb, T.Z. 882Deeudom, M. 139Deguchi, K. 1310


1378 Author index

Delaney, S.J. 313Delgado, M.J. 108, 195Della Torre, C. 1228Dellis, O. 910del Zoppo, G.J. 1261Deng, W. 1051Deplanque, D. 1341de Vos, R.A.I. 738de Vries, S. 136Di Benedetto, G. 495Dillon, J. 942Ding, J.L. 270Dixon, R. 162, 191Doddapaneni, H. 1165Dolman, N.J. 381Dolphin, A.C. 894Dolton, G.M. 1041Dong, G. 683Dong, S. 39Donnelly, P. 526Dorin, J.R. 257Douglas, L. 894Doyle, T.M. 965Draeger, A. 374Dridge, E.J. 118Dryden, D.T.F. 317Duchesne, L. 427Duff, J. 1098Duncan, R.R. 679Dunford, A.J. 1178Duriez, P. 1341Dworakowski, R. 960Dyachok, O. 498Dyet, K. 197

Eastwood, H. 257Ehlting, J. 1192Ehnholm, C. 389Eichler, T.W. 671Eilmus, S. 169Elliott, J.E. 223Endo, H. 1283Eulenburg, V. 55Eve, T. 304

Faber, K. 296Fahey, M. 587Fang, X. 798Faro-Trindade, I. 1133Feingold, E. 578Ferguson, S.J. 91, 150Fernie-King, B.A. 273Fernig, D.G. 427Ferris, V. 557Feyereisen, R. 1252Fischer, H.-M. 156Fischmeister, R. 484Fisher, M. 1271Fitch, P.M. 279Flatt, P.R. 774Flock, U. 188Focardi, S. 1228Fogli, A. 22Foka, P. 1141Forster, M. 431Fotheringham, I. 287Fraaije, B.A. 1219Francis, R.E. 722

Franklin, F.C.H. 542Frebel, K. 1287Freeman, C. 526Freeman, H. 806Fruchart, J.C. 1128, 1341Fujita, J. 746Fukuda, M. 691

Gadler, P. 296Gagnon-Kugler, T. 1079Galione, A. 922Gallagher, J.T. 438Galliera, E. 1014Gamble, S.C. 1124Ganesan, R. 39Gartland, K.M.A. 1151Gautier, S. 1341Geetha, T. 757Geiduschek, E.P. 1082Gele, P. 1341George, C.H. 913Gerasimenko, O.V. 381Gerdes, H.-H. 671Geretti, E. 435Gerhardt, H. 454Gerstein, A.C. 519Gherardi, E. 414Ghigo, A. 502Ghosh, S. 39Giardina, G. 185Gibson, W. 557Gilbert, L.I. 1256Ginsberg, M.D. 1323Girvan, H.M. 1173, 1178Glawischnig, E. 1206Gledhill, J.R. 989Glueck, S.M. 296Goetz, J.G. 370Goldfarb, D.S. 340Gomeza, J. 55Gomez-Villalba, B. 165Gonzalez, W. 899Gonzalez-Herrera, I.G. 17Gonzalez-Lopez, J. 165Gonzalez-Nilo, F.D. 899Good, L. 1148Goodman, B. 716Gorina, R. 1267Graham, G.J. 1002Graham, S.V. 1145Grant, S.G.N. 59Gray, B.C. 51Green, B.D. 774Greenwood, S. 863Griac, P. 377Griffiths, L. 104Griffiths, W.J. 1246Grocott, T. 761Grosshans, B. 683Guengerich, F.P. 1183Gustafsson, J.-Å. 1114Guven, D. 174Gwyer, E. 1032Gwyer, J.D. 133

Haaijer, S.C.M. 174Haelens, A. 1089

Hales, T.G. 882Halestrap, A.P. 232Hall, J. 267Hallenbeck, J.M. 1295Hallermann, S. 939Halling, P.J. 309Hamberger, B. 1209Hamilton, T.L. 12Hanley, J.G. 931Hannemann, F. 1215Hansell, C.A.H. 1009Hao, H.-X. 791Hardingham, G.E. 936Hargrove, T.Y. 1161Harhangi, H.R. 174Harmer, N.J. 442Haros, K. 761Harrison, K. 1199Hart, P. 1155Hartshorne, S. 146Hasnaoui, G. 291Hauer, B. 291Hawkins, P.T. 647Hayashi, H. 399He, F. 39Heckmann, M. 939Hemmings, A.M. 143Hennecke, H. 156Herrmann, O. 1291Hers, I. 209Hetzenauer, A. 903Hiemstra, P.S. 276Higgins, J.D. 542Higman, V.A. 446Hill, M.D. 1323Hirsch, E. 502Ho, B. 270Hobman, J.L. 104Hohenester, E. 418Holden-Dye, L.M. 43, 942Holic, R. 377Hontoria, E. 165Hopper, N.A. 942Houslay, M.D. 474, 504Houslay, T.M. 504Howie, S.E.M. 279Howitt, J.A. 418Hsieh, L. 1366Hsu, J.-Y. 1047Hsu, S.C. 687Huertas, M.-J. 152Hughes, R.K. 1223Hundsrucker, C. 472Hung, C.-C. 743Hung, S. 1261Hunt, P.A. 574Hussain, S. 418Hussell, T. 1032Huston, E. 504Hutagalung, A. 683Hynynen, R. 389Holtta-Vuori, M. 392

Iino, R. 993Ikonen, E. 392Inta, I. 1291Irvine, S.A. 1141Isakov, Y. 498


Author index 1379

Jackson, N. 542Jacobson, A. 39Janssen, D.B. 291Janssen, G.M.C. 819Jauhiainen, M. 389Jayawickreme, C.K. 770Jeganathan, K.B. 583Jepson, B.J.N. 122, 195Jetten, M.S.M. 174, 179Jeyabalan, G. 957Jiang, H.-Y. 7Jin, S. 68Johansson, M. 389Johnston, J.A. 764Joly, N. 1067Jones, G.H. 542Jordan, P. 545Joussen, N. 1241Jungmann, V. 1236Juven-Gershon, T. 1047Jørgensen, R. 1

Kaderbhai, M.A. 1231Kaderbhai, N.N. 1231Kadonaga, J.T. 1047Kamiya, T. 1310Kamiya, Y. 1199Kamphorst, W. 738Kampschreur, M.J. 179Karlsson, M. 842Kartal, B. 174Karten, B. 399Kashemsant, N. 802Kassavetis, G.A. 1082Kazanietz, M.G. 855Keeney, S. 523Kelly, D.E. 1159Kelly, S.L. 1159, 1231Kemp, L.E. 414Kendall, D.A. 1095Kervestin, S. 39Keyse, S.M. 842Kiledjian, M. 35Kim, S.H. 1219Kittel, R.J. 939Kjellen, L. 454Klumpp, S. 1370Klussmann, E. 472Konarev, P.V. 605Kondo, K. 17Korotchkina, L.G. 217Koschak, A. 903Koziol, J.A. 1261Krieglstein, J. 1370Kros, J.M. 738Kroutil, W. 296Krzywkowski, K. 872Kuenen, J.G. 174Kulpa, J.E. 223Kungl, A.J. 435Kupzig, S. 846Kurup, S. 454Kushiro, T. 1199Kutschker, J. 591Kuypers, M.M.M. 174Kvam, E. 340Kogel, T. 671

Lachmann, P.J. 273Lafer, E.M. 68Lai, F.A. 913, 919Lam, E.W.-F. 722Lamb, D.C. 1159Lamb, N.E. 578Lamba, D. 605Lambert, J.J. 882Landick, R. 1062Lane, C. 1246Langlois, F. 1079Laprais, M. 1341Larin Monaco, Z. 324Larissegger-Schnell, B. 296Lavalette, D. 975Lavery, D.N. 1054Layfield, R. 735Lee, W.M. 223Lee, Y.-J. 1295Lehto, M. 389Lemkes, H.H. 819Lepesheva, G.I. 1161Lesa, G.M. 77Lev, S. 363Leverentz, M.K. 794Lewis, R.J. 118Leys, D. 1173, 1178Li, C. 39Li, J.P. 454Li, P. 270Lightman, S.L. 1117Lindahl, U. 454Lindsay, J.G. 815Lissandron, V. 495Lisurek, M. 1215Little, R. 162Liu, H. 35Livesey, M.R. 882Locati, M. 1014Loder, M.K. 675Loenen, W.A.M. 330Long, J. 735Lorenz, A. 537Lortat-Jacob, H. 461Lovestone, S. 88Lovis, P. 696Lu, B. 395Lu, C.-Z. 1327Lucas, J.A. 1219Ludikhuize, J. 727Lukiw, W.J. 1277Luque-Almagro, V.M. 152Lutje Spelberg, J.H. 291Lygren, B. 489Levy, R. 427

Maassen, J.A. 819Mabuchi, T. 1261Macrae, I.M. 1362Maechler, P. 811, 824Maier, C.M. 1366Maillard, M. 761Majeric-Elenkov, M. 291Malik, H.S. 569Malik, P. 705Mancuso, L. 495Mandl, M. 842Mangelsdorf, D.J. 1110

Mangus, D.A. 39Manson, J.C. 1155Mantovani, A. 1014Maricq, A.V. 64Marietou, A. 122Marshall, K.R. 1178Martin, A.C.L. 480Martinez-Argudo, I. 162Martinez de la Torre, Y. 1014Martınez-Espinosa, R.M. 115Martınez-Luque, M. 127, 152Martin-Gronert, M.S. 779Marza, E. 77Mashanov, G.I. 983Matsuda, M. 851Matthews, R.J. 1041Maxfield, F.R. 335Mayer, R.J. 746McCormack, J.G. 238McCormick, S. 283McCullough, J. 754McDougall, A. 385McEwan, I.J. 1054, 1098McKimmie, C.S. 1002McLean, K.J. 1173, 1178McPhillips, M.G. 1145McVean, G. 526Meakin, G.E. 195Medkova, M. 683Meggio, F. 1303Mellor, J.R. 949Menon, A.K. 356Merrill, A.R. 1Mesa, S. 156Messaoudi, E. 600Millson, S.H. 783Milner, C.M. 446Milner, R. 1261Milona, P. 267Minier, F. 868Minor, Jr, D.L. 887Miroslavova, N.S. 1075Mitchell, J.E. 1075Mizielinska, S. 863Mizutani, M. 1202Moehren, U. 1089Mohan, S. 122Moir, J. 139, 197Mole, S. 1145Molina-Munoz, M.L. 165Molloy, J.E. 983Molnar, I. 1236Mondal, M. 335Mongillo, M. 510Montchamp-Moreau, C. 562Montoya, T. 1199Moore, D.J. 749Moralli, D. 324Moreno-Vivian, C. 127, 152Morgan, J.R. 68Morikawa, T. 1202Moss, T. 1079Mouawad, L. 975Mousley, C.J. 346Mudher, A. 88Mulle, C. 927Mulloy, B. 409, 414, 431Munro, A.W. 1173, 1178


1380 Author index

Murray, N.E. 203Murray, P.J. 1028Myers, S. 526Mezard, C. 531

Nabi, I.R. 370Najat, D. 735Nakamura, T. 851Narasimhan, P. 1366Nassenstein, C. 591, 594Neale, M.J. 523Neeli, R. 1173, 1178Nenasheva, T.A. 983Nes, W.D. 1161Nestl, B.M. 296Newbury, S.F. 30Newman, T.A. 88Newsholme, P. 811Nguyen, N.K. 903Nibbs, R.J.B. 1009Nichols, R.J. 427Niemeyer, M.I. 899Niquet, J. 1347Noji, H. 993Nomura, T. 1199Noren, A. 160Novick, P. 683Nuttall, J. 783

O’Connor, V.M. 43, 51, 942Ohta, D. 1202Ohvo-Rekila, H. 356Okano, H. 1310Olkkonen, V.M. 389Olmo-Mira, F. 127Ooi, L. 1138Op den Camp, H.J.M. 174Ortiz de Montellano, P.R. 1170Osman, K.E. 542Ott, R.D. 1161Otto, S.P. 519Ouk, T. 1341Overton, T.W. 104Ozanne, S.E. 779

Paarmann, I. 45Pachlatko, J.P. 1236Pagano, M.A. 1303Paik, J.-H. 731Palesch, Y.Y. 1323Pandey, A.V. 1186Paoletti, F. 605Papadakis, M. 1318Pape, T. 1067Parker, M.G. 1103Parry, H. 385Parton, L. 247Patel, M.D. 104Patel, M.S. 217Pavlov, V.A. 1037Peacock, L. 557Peckham, M. 983Peleshok, J. 612Pelster, G. 903Penn, C.W. 104Perino, A. 502Perry, V.H. 51Peters, J.A. 882

Petkovic, M. 722Petrault, O. 1341Philippot, L. 101Piccinini, A.-M. 435Picioreanu, C. 174, 179Pinna, L.A. 1303Pino, C. 127Piper, P.W. 783Plaisance, V. 696Planas, A.M. 1267Plesnila, N. 1334Potzinger, H. 435Powell, S.M. 1124Pozo, K. 48Prado-Lourenco, L. 17Prasad, K. 68Prats, A.-C. 17Prinz, W.A. 359Prior, I.A. 754Proost, P. 997Proud, C.G. 213Proudfoot, A.E.I. 422Provart, N.J. 1192Pruenster, M. 1005

Rackham, O. 328Raff, M. 663Ralston, S.H. 735Ramji, D.P. 1141Ramos, A. 165Raper, A. 1024Rappas, M. 1067Ravier, M.A. 247, 675Raychaudhuri, S. 359Reebye, V. 1124Reece, R.J. 794Reedquist, K.A. 727Rees, C. 427Regazzi, R. 696Reijnders, W.N.M. 94Reiling, E. 819Reimann, J. 188Reinisch, K. 683Rek, A. 435Rewitz, K.F. 1256Reznikoff, W.S. 320Richardson, D.J. 115, 118, 122, 133, 143,

146, 195Rider, C.C. 409, 458Riekhof, W.R. 404Riezman, H. 367Rinaldo, S. 185Roberts, G.C.K. 971Roberts, S.G.E. 1051Robinson, P.A. 743Robles, E.F. 108Rochais, F. 484Rochlitzer, S. 594Rock, J. 139Rodelas, B. 165Roghanian, A. 279Roldan, M.-D. 127, 152Rolfes, R.J. 786Romijn, J.A. 819Rosch, C. 169Rosenthal, W. 472Rot, A. 1005Row, P. 754

Rudd, T.R. 427Rutter, G.A. 247, 351, 675, 791Rutter, J. 791Ryan, M.M. 346Rybczynski, R. 1256

Sabri, M. 1178Sacks, D.B. 833Saito, A. 1283Saiyed, T. 45Saklatvala, J. 456Sallenave, J.-M. 279Salvemini, D. 965Sanchez-Moran, E. 542Santosuosso, M. 283Saragovi, H.U. 612Sathish, J.G. 1041Sawamoto, K. 1310Sayner, S. 492Schabitz, W.-R. 1271Scherthan, H. 550Scheuer, T. 1299Schirmer, E.C. 705Schmid, M.C. 174Schmidt, B. 1241Schmidt, I. 179Schmitt, B. 45Scholze, P. 55Schuklenk, U. 1151Schumacher, J. 1067Schuphan, I. 1241Schwaninger, M. 1291Schwarz, E. 605Scott, J.D. 73, 465Scrutton, N.S. 1173Searle, M.S. 735Seibert, C. 1246Seilly, D.J. 273Semple, C.A.M. 257Semplici, F. 791Seo, D.-W. 1347Sepulveda, F.V. 899Sessions, R. 587Seward, H.E. 1178Shah, A.M. 960Shapleigh, J.P. 130Sharif, A. 1246Shepherd, D. 88Sheppard, P.W. 735Sherman, S.L. 578Sherwood, M.W. 381Shimada, T. 1183Shimomura, K. 806Shoemark, D. 587Sigel, E. 868Sigrist, S.J. 939Simgen, B. 1215Simon, J. 146Simon, R. 1356Simpson, C.V. 1009Singewald, N. 903Singh, N.N. 1141Sinnegger-Brauns, M.J. 903Skidmore, M.A. 427Skipp, P. 51Smolle, M. 815Snelgrove, R. 1032Soderling, S.H. 73


Author index 1381

Soule, J. 600Spatrick, P. 39Speight, R. 287Spencer, C.C.A. 526, 535Spillmann, D. 454Spiro, S. 191, 200Spriggs, K.A. 12Staels, B. 1128, 1341Stefanovsky, V. 1079Stege, J. 1236Stenzel-Poore, M.P. 1352Stephens, L.R. 647Stephenson, F.A. 43, 48, 877Stevens, S.L. 1352Stevens, T. 492Stewart, M. 701Stokka, A.J. 476Stone, J.C. 858Stoneley, M. 12Striessnig, J. 903Stringer, S.E. 451Strous, M. 174Strube, K. 182Struyf, S. 997Subramanian, V. 1165Suchanek, M. 389Sullivan, D.P. 356Sun, M. 270Sun, Y. 1095Svergun, D.I. 605Sweeney, G. 798Szatmari, A.-M. 1199Szekeres, M. 1199Sanchez, C. 108Sågetorp, J. 498

Tahotna, D. 377Tak, P.P. 727Tan, N.C.G. 179Tanner, T. 1089Tasken, K. 476, 489Tavare, J.M. 209Taylor, C.W. 515, 910Taylor, K. 257Tebbutt, J. 1075ten Dijke, P. 761Tengholm, A. 498Tepikin, A.V. 381Teria, M. 304Terrin, A. 495Terry, C.J. 427Teshima-Kondo, S. 17Tetreau, C. 975Thanh, N.T.K. 427’t Hart, L.M. 819Thiele, C. 389Thissen, M.-C. 1370Thomas, C.M. 1072Thomas, N.L. 913Thomsen, S. 939

Timmons, J.A. 1148Tock, M.R. 317Toffanin, A. 130Tomasetto, C. 343Tovey, S.C. 515Townes, C.L. 267Tracey, K.J. 1037Trefzer, A. 1236Truman, A.W. 783Tsuboi, T. 247Tsung, A. 957Tucker, N.P. 191Tumes, D. 591Turner, N.J. 287Tyeryar, K.R. 346Tyler, S. 587

Ubeda, F. 566Ueberbacher, B.T. 296Urbe, S. 754

Vance, J.E. 399Van Damme, J. 997Vandecasteele, G. 484van de Pas-Schoonen, K.T. 174van der Star, W.R.L. 174van Deursen, J.M. 583van de Vossenberg, J. 174van Leeuwen, F.W. 738van Loosdrecht, M.C.M. 174, 179van Niftrik, L.A.M.P. 174Van Petegem, F. 887van Schravendijk, C. 738van Spanning, R.J.M. 94Varadi, A. 247Vecchi, A. 1014Veerapraditsin, T. 1145Veldman, R. 94Verras, A. 1170Verrijdt, G. 1089Vijayakrishnan, N. 81Vilchez, R. 165Villalba-Galea, C.A. 68Vincent, T. 456Virus, C. 1215Voelker, D.R. 404Voronina, S.G. 381

Wabitsch, V. 435Wada-Hiraike, O. 1114Wakeley, J. 560Walker, J.E. 989Wallner, S.R. 296Waltham, T.N. 1173Wang, He 160Wang, HongBin 855Wang, S. 687Wang, X. 1261Wang, Y. 1246Warner, M. 1114Warren, J.T. 1256

Wasterlain, C.G. 1347Waterman, M.R. 1161, 1183Watson, J. 587Watson, R.A. 560Watt, K. 1098Weinreich, D.M. 560Wek, R.C. 7Welchman, R. 754Wells, A. 304Welsh, G.I. 209Werck-Reichhart, D. 1192Wherlock, M. 209Whitaker, H.C. 1124Whitaker, M. 385Whitby, M.C. 537White, R. 1103Whitehead, R.N. 111Whitmarsh, A.J. 828Wichmann, C. 939Wicks, S.J. 761Wiertz, F.G.M. 136Wiese, S. 1287Wigneshweraraj, S. 1067Williams, K. 557Willis, C. 587Willoughby, D. 468Wingate, A.D. 1107Wood, I.C. 1138Woodley, J.M. 301Wooten, M.W. 757Wratten, J. 894Wright, M.C. 1119Wu, W.-I. 404

Xiao, B.-G. 1327Xing, Z. 283Xiong, Z. 1356Xu, C. 395

Yadav, J.S. 1165Yamaguchi, S. 1199Yamashita, T. 1310Yan, D. 389Yarwood, S. 846Yates, E.A. 427Ying, Z. 174Yokota, T. 1199Yoshizaki, H. 851

Zaccolo, M. 495, 510Zamparo, I. 495Zampieri, N. 607Zhang, J. 1024Zhang, M. 960Zhang, R. 587Zhang, X. 1067Zhang, X.Z. 283Zheng, Y. 716Zissimopoulos, S. 919Zuniga, L. 899


subjectindex

AAA+ activator (see ATPase associated withvarious cellular activaties activator)

ABC transporter (see ATP-binding-cassettetransporter)

Aβ (see amyloid β-peptide)AC (see adenylate cyclase)ACC (see acetyl-CoA carboxylase)acetylcholine, 381acetyl-CoA carboxylase (ACC), 223ACh receptor (see nicotinic acetylcholine

receptor)acidotoxicity, 1356acid-sensing ion channel (ASIC), 1356actin, 550actin remodelling, 73action potential, 1299activation of transcription, 1075active-site channel, 143active-site coupling, 815active zone, 939adaptor protein, 48, 68adenine, 786S-adenosylmethionine, 330adenylate cyclase (AC), 468, 480, 492, 510adipocyte, 819, 1103adipokine, 798adiponectin, 798ADP-ribosylation, 1adrenal gland, 1110adrenergic receptor, 484β2-adrenergic receptor (β2Ar), 474β-adrenoceptor, 510age-related infertility, 583aggresome, 743aging, 581, 743AIF (see apoptosis inducing factor)airway hyperreactivity, 591airway hyperresponsiveness, 594airway inflammation, 591, 594AKAP (see A-kinase-anchoring protein)A-kinase-anchoring protein (AKAP), 73,

465, 472, 480, 489Akt (see protein kinase B)albumin, 1323aldehyde, 304alkalophile, 152all-and-none segregation, 566allele, 560allene oxide synthase (AOS), 1192, 1223allergic asthma, 591allosteric protein, 931alphoid DNA, 324Alzheimer’s disease, 88, 587, 1277AMFR (see autocrine motility factor

receptor)α-amino-3-hydroxy-5-methylisoxazole-4-

propionic acid receptor (AMPAR),931

ammonia oxidation, 179AMP-activated protein kinase (AMPK), 223AMPAR (see α-amino-3-hydroxy-5-

methylisoxazole-4-propionic acidreceptor)

AMPK (see AMP-activated protein kinase)AMSH (see associated molecule with the

Src 3 homology domain of signaltransducing adaptor molecule)

amyloid β-peptide (Aβ), 1277

amyloid precursor protein (APP), 607, 828anaerobic ammonium oxidation

(anammox), 174anaerobic growth, 97anammox (see anaerobic ammonium

oxidation)anaphase-promoting complex, 583androgen receptor, 1089, 1124aneuploidy, 583angiogenesis, 451, 731, 1327angiotensin, 960Anguilla anguilla (Linnaeus, 1758) (see

European eel)annexin, 374anti-androgen, 1124anti-apoptosis, 1327antibacterial protein, 267antibody, 612antigen-presenting cell, 1032anti-inflammatory cytokine, 1267anti-inflammatory drug, 435antimicrobial peptide, 251, 257, 273, 276anti-protease, 267AOS (see allene oxide synthase)apolipoprotein E, 399, 1141apoptosis, 7, 232, 936, 1114, 1283, 1287,

1303, 1370apoptosis inducing factor (AIF), 1334, 1347APP (see amyloid precursor protein)AQP2 (see aquaporin-2)aquaporin-2 (AQP2), 472β2Ar (see β2-adrenergic receptor)Arabidopsis, 531, 542, 1192, 1199, 1206Aralar1, 811Archaeoglobus fulgidus, 118archaeon, 115aromatization, 304β-arrestin, 474arrhythmia, 913arrhythmogenic right ventricular

cardiomyopathy/dysplasia type 2(ARVC/D2), 913

articular cartilage, 456artificial chromosome, 324ARVC/D2 (see arrhythmogenic right

ventricular cardiomyopathy/dysplasiatype 2)

AS160, 209ASIC (see acid-sensing ion channel)assimilation, 127assimilatory nitrate reductase (NAS), 122associated molecule with the Src homology

3 domain of signal transducingadapter molecule (AMSH), 754

asthma, 594atherosclerosis, 1141ATPase associated with various cellular

activities activator (AAA+ activator),1067

ATPase synthase, 989ATP-binding-cassette transporter (ABC

transporter), 359, 395ATP hydrolysis, 1067ATP-sensitive potassium channel (KATP

channel), 243atrial natriuretic peptide, 1138atypical chemokine receptor, 1009Aurora A, 716

aurovertin, 989autocrine motility factor receptor (AMFR),

370autoimmune disease, 1041autoimmunity, 1032autophagy, 340avermectin, 1236avian WAP (whey acidic protein) domain-

and Kunitz domain-containing protein(AWAK protein), 267

AWAK protein [see avian WAP (whey acidicprotein) domain- and Kunitzdomain-containing protein]

AWAP IV, 267axon guidance, 418azide, 291azole binding, 1170, 1178Azotobacter vinelandii, 162

BBacillus, 1173bacterial chromosome, 203bacterial cultivation, 101bacterial cytochrome P450, 1215bacterial enhancer binding protein, 1067bacterial lipid, 270bacterium, 492, 1072bafilomycin, 922Bag1 (see Bcl-2-associated athanogene 1)BAS1, 786basal transcription factor, 1054basic fibroblast growth factor (bFGF), 456Bcl-2-associated athanogene 1 (Bag1),

1287BDNF (see brain-derived neurotrophic

factor)Bdp1, 1082benzodiazepine, 863, 868β-cell, 247, 675, 774, 791, 806, 811, 824bFGF (see basic fibroblast growth factor)bicalutamide, 1124Bid, 1334binding partner, 842biocatalysis, 287, 291, 296, 1236biocatalytic process, 301biodegradation, 152biodiversity, 165, 169, 1148, 1161biofilm, 165biofilter, 165biogenesis, 863bioimaging, 983bioinformatics, 313biomarker, 1159biophysical characterization, 442biotin, 223biotransformation, 287, 1231bird flu, 1151birth weight, 779bisphenol A, 574blood–brain barrier, 1261, 1366blood genomic profiling, 1313BM3, 1173BMP (see bone morphogenetic protein)BMP antagonist (see bone morphogenetic

protein antagonist)bone morphogenetic protein (BMP), 458bone morphogenetic protein antagonist

(BMP antagonist), 458


1384 Subject index

bouquet, 550bovine spongiform encephalopathy (BSE),

1155Bradyrhizobium japonicum, 108, 156, 195brain, 232, 828, 1307brain-derived neurotrophic factor (BDNF),

594, 600brain function, 903brain injury, 1366brain ischaemia, 1356brain natriuretic peptide, 1138branched respiratory chain, 139brassicasterol, 1202brassinolide, 1199brassinosteroid, 1199BRCA1, 633BRCA2, 633Brf1, 1082BRP (see Bruchpilot)Bruchpilot (BRP), 939BSE (see bovine spongiform

encephalopathy)budding yeast, 1082

CC1 domain, 855CaV (see voltage-gated calcium channel)CACH/VWM (see childhood ataxia with

central nervous system hypomyelina-tion/leukoencephalopathy withvanishing white matter syndrome)

Caenorhabditis elegans, 64, 77, 942calcium, 228, 370, 374, 468, 498, 504, 515,

1356calcium-binding protein, 381calcium channel, 903, 913, 939calcium-dependent facilitation (CDF), 887calcium-dependent inactivation (CDI), 887calcium-promoted Ras inactivator (CAPRI),

846calcium sensor, 931calcium signalling, 381, 919, 936calcium signalling microdomain, 385calcium store, 922calcium transport, 351calmodulin (CaM), 381, 480, 887µ-calpain, 51CaM (see calmodulin)camalexin, 1206cAMP, 468, 472, 476, 484, 489, 492, 498,

502, 510, 515cAMP cycling, 465cAMP-dependent protein kinase (see

protein kinase A)cAMP microdomain, 480cAMP receptor protein (CRP), 1075cAMP receptor protein/fumarate and

nitrate reductase regulator superfamily(CRP/FNR superfamily), 185

cAMP receptor protein/fumarate andnitrate reductase regulatoryprotein-like transcription factor(CRP/FNR-like transcription factor),156

cAMP-response element (CRE)-bindingprotein (CREB), 936

cAMP signalling, 495

cAMP-specific phosphodiesterase-4 (PDE4),474, 504

cancer, 330, 581, 1114cannabinoid receptor (CB receptor),

1095capacitative Calcium entry (CCE), 480CAPRI (see calcium-promoted Ras

inactivator)cardiac cell, 228cardiac hypertrophy, 1138cardiac myocyte, 484cardiac pathology, 913cardiomyocyte, 510cardiovascular disease, 903cardiovascular system, 960caspase, 1334, 1347catalyst cost, 301catalytic activity, 1161catalytic cycle, 136catalytic domain, 989catecholaminergic polymorphic ventricular

tachycardia, 913catenin, 1114CB receptor (see cannabinoid receptor)CC chemokine, 1002CC chemokine receptor (CCR), 1014CCE (see capacitative Ca2+ entry)Ccm (see cytochrome c maturation)CCR (see CC chemokine receptor)CcsA, 146CD45, 1041CDF (see calcium-dependent facilitation)CDI (see calcium-dependent inactivation)cell biochemistry, 983cell–cell signalling, 442cell-cycle regulator, 746cell death, 953cell differentiation, 1133cell engineering, 301cell fate, 722cell imaging, 495cell-surface biotinylation, 894cell-surface receptor, 647cell survival, 1107cellular immunity, 283cellular proliferation, 1114cellular receptor, 418central nervous system (CNS), 51, 903,

1095centromere complexity, 569centromeric histone, 569ceramide synthase, 367cerebral ischaemia, 1291, 1310, 1327,

1341, 1362, 1366cGMP, 512cGMP-specific and -stimulated

phosphodiesterases, Anabaenaadenylate cyclases and Escherichia coliFhIA domain (GAF domain), 191

checkpoint, 554, 711chemoattractant, 1014chemokine, 422, 997, 1005chemokine mutant, 435chemokine sequestration, 1009chemotaxis, 997childhood ataxia with central nervous

system hypomyelina-tion/leukoencephalopathy with

vanishing white matter syndrome(CACH/VWM syndrome), 22

chimaeric protein, 111β2-chimaerin, 855chiral amine, 287chloroplast, 395cholesterol, 335, 343, 392, 399, 1110,

1128cholesterol homoeostasis, 1141cholinergic anti-inflammatory pathway,

1037chromatin, 1138chromatin loop, 1133chromatin remodelling, 1103chromosomal exchange, 554chromosome 21, 578chromosome axis, 554chromosome missegregation, 583chromosome segregation, 537chronic wasting disease (CWD), 1155cis-acting RNA element, 1145CJD (see Creutzfeldt–Jakob disease)c-Jun N-terminal kinase (JNK)-interacting

protein (JIP), 828Class I phosphoinositide 3-kinase (Class I

PI3K), 647Class I PI3K (see Class I phosphoinositide

3-kinase)clathrin, 68clinical trial, 1271CNG channel (see cyclic nucleotide-gated

channel)CNS (see central nervous system)co-expression analysis, 1192co-receptor, 414co-stimulation, 1032collybistin, 45colonic epithelium, 1114compartmentalization, 465, 502composite sulphated region, 438computer-based assignment tool, 169concatenated subunit, 868confocal microscopy, 48, 309, 675conformational mobility, 1170conifer, 1209core promoter, 1051cortex, 385corticosterone, 1110, 1117cosmid, 203CREB [see cAMP-response element

(CRE)-binding protein]Creutzfeldt–Jakob disease (CJD), 1155Crohn’s disease, 263crossover, 531, 537crossover interference, 542CRP (see cAMP receptor protein)CRP/FNR-like transcription factor (see

cAMP receptor protein/fumarate andnitrate reductase regulatoryprotein-like transcription factor)

CRP/FNR superfamily (see cAMP receptorprotein/fumarate and nitratereductase regulator superfamily)

cryo-electron microscopy, 1crystallographic analysis, 587crystal structure, 989, 1051, 1089Csk (see C-terminal Src kinase)C-terminal Src kinase (Csk), 476


Subject index 1385

cupredoxin, 139CWD (see chronic wasting disease)cyanide, 152, 291cyanine dye, 979cybrid, 824cyclic nucleotide-gated channel (CNG

channel), 468, 484cyclin-dependent kinase, 523CYP (see cytochrome P450)CYP1A (see cytochrome P450 1A)CYP51 (see cytochrome P450 51)CYP63 (see cytochrome P450 63)CYP74 (see cytochrome P450 subfamily 74)CYP79B2 (see cytochrome P450 79B2)CYP85 (see cytochrome P450 85 clan)CYP101 (see cytochrome P450 101)CYP102 (see cytochrome P450 102)CYP106A2 (see cytochrome P450 106A2)CYP121 (see cytochrome P450 121)CYP710A (see cytochrome P450 710A)Cys-loop family, 882cytochrome, 139cytochrome bc1 complex, 195cytochrome b5, 1231cytochrome c, 143, 1186, 1283, 1334cytochrome c biogenesis System I, 150cytochrome c biogenesis System II, 146cytochrome c maturation (Ccm), 91, 150cytochrome c nitrite reductase, 133, 146cytochrome oxidase, 136cytochrome P450 (CYP/P450), 975, 1159,

1161, 1165, 1170, 1173, 1178, 1183,1186, 1192, 1199, 1202, 1209, 1215,1219, 1223, 1228, 1231, 1236, 1241,1246, 1252, 1256

cytochrome P450 1A (CYP1A), 1228cytochrome P450 51 (CYP51), 1161, 1219cytochrome P450 63 (CYP63), 1165cytochrome P450 79B2 (CYP79B2), 1206cytochrome P450 85 clan (CYP85), 1209cytochrome P450 101 (CYP101), 1170cytochrome P450 102 (CYP102), 1173cytochrome P450 106A2 (CYP106A2), 1215cytochrome P450 121 (CYP121), 1178cytochrome P450 710A (CYP710A), 1202cytochrome P450 reductase, 1186cytochrome P450 subfamily 74 (CYP74),

1223cytokine, 409, 1018cytokine adjuvant, 283cytoprotection, 1295cytoskeletal organization, 73cytosol, 492cytosolic phospholipase A2, 1277c-type cytochrome, 91, 150

DD6, 1002, 1009damage-associated molecular pattern

(DAMP), 957DAMP (see damage-associated molecular

pattern)DARC (see Duffy antigen receptor for

chemokines)decapping enzyme, 35decoy receptor, 1014defensin, 251, 263β-defensin, 257

dehydroergosterol, 335dendritic cell, 283, 957denitrification, 94, 108, 115, 130, 139, 156,

165, 182, 185denitrifier, 101depolarization, 1299deracemization, 287, 296Desulfovibrio desulfuricans, 122detergent micelle, 1223de-ubiquitinating enzyme, 746, 761, 764developmental programming, 779developmental timing, 663DHA (see docosahexaenoic acid)diabetes, 17, 243, 696, 770, 774, 798, 824diabetes mellitus (Type 2), 247, 738, 779,

802, 806, 819diacylglycerol, 363, 855, 858differentiation, 663dihydropyridine, 903dihydrotestosterone, 1098dilute mouse, 671dimerization, 1089dinitrogenase reductase activating

glycohydrolase (DRAG), 160dinitrogenase reductase ADP-ribosylation

transferase (DRAT), 160diphthamide, 1diphtheria toxin, 1directed evolution, 328, 1215dissimilative nitrate respiration regulator

(DNR), 185distantly related to SIC (DRS), 273disulfide bond, 894diterpene resin acid (DRA), 1209DNA binding, 1089DNA-binding protein inhibitor, 317DNA damage, 554DNA-damage sensing, 633DNA double-strand break, 523DNA helicase, 537DNA microarray, 101DNA mimicry, 317DNA opening, 1067DNA repair, 633, 764DNA technology, 203DNR (see dissimilative nitrate respiration

regulator)docking, 431docking machinery, 691docking site, 837, 975docosahexaenoic acid (DHA), 1277domain structure, 438double Holliday junction, 542Down’s syndrome, 578downstream core promoter element (DPE),

1047DPE (see downstream core promoter

element)DRA (see diterpene resin acid)DRAG (see dinitrogenase reductase

activating glycohydrolase)DRAT (see dinitrogenase reductase

ADP-ribosylation transferase)drift, 519Drosophila, 88, 512Drosophila embryo, 385Drosophila melanogaster, 1252Drosophila simulans, 562

DRS (see distantly related to SIC)drug discovery, 238, 313druggable kinome, 1303drug metabolism, 1186drug target identification, 313DsRed, 351dual polarization interferometry, 427dual-specificity phosphatase (DUSP), 1018Duffy antigen, 1005, 1014Duffy antigen receptor for chemokines

(DARC), 1009DUSP (see dual-specificity phosphatase)dwarfism, 1199dynamin-1, 675dystroglycan, 1261

EE3 ubiquitin ligase, 749ecdysone, 1256EcoKI, 330EF2 (see elongation factor 2)EGF (see epidermal growth factor)EGFR (see epidermal growth factor

receptor)eIF (see eukaryotic initiation factor)eIF2 (see eukaryotic initation factor 2)eIF2B (see eukaryotic initiation factor 2B)elafin, 279elastase, 279electron transfer, 188, 1173electron transport, 1183electron transport chain, 130elongation factor 2 (EF2), 1emamectin benzoate, 1236enantioconvergence, 296endocytic recycling compartment, 335endocytosis, 77, 754, 1024endoplasmic reticulum, 351, 356, 359, 367,

385, 395, 404, 910, 922endoplasmic reticulum-associated

degradation (ERAD), 370endoplasmic reticulum junction, 389endoplasmic reticulum membrane contact

site, 340endosomal sterol-binding protein, 392endothelial cell, 492, 1005, 1366, 1370endotoxin, 270energy metabolism, 811, 815Epac (see exchange protein directly

activated by cAMP)epidermal growth factor (EGF), 754epidermal growth factor receptor (EGFR),

855epigenetic modification, 779epigenetics, 1148epilepsy, 863epistasis, 519, 560epithelial cell, 276epithelial differentiation, 1145epoxide, 291ERβ (see oestrogen receptor β)ERAD (see endopasmic

reticulum-associated degradation)ergosterol, 356ERK (see extracellular-signal-regulated

kinase)EROD (see

7-ethoxyresorufin-O-de-ethylase)


1386 Subject index

erythrocyte, 1005Escherichia coli, 91, 133, 200, 1183, 1231Escherichia coli flavorubredoxin, 1917-ethoxyresorufin-O-de-ethylase (EROD),

1228eukaryotic initiation factor (eIF), 213eukaryotic initiation factor 2 (eIF2), 7eukaryotic initiation factor 2B (eIF2B), 22European eel [Anguilla anguilla (Linnaeus,

1758)], 1228evolution, 526, 569, 1252evolutionary genetic stability, 566evolution of sex, 519exchange protein directly activated by

cAMP (Epac), 468excitation–contraction coupling, 489excitotoxicity, 936, 1307exocyst, 687exocytosis, 472, 671, 675, 683exocytotic apparatus, 696exogenous sterol, 359exotoxin A, 1extracellular matrix, 454, 1261extracellular pH, 899extracellular-signal-regulated kinase (ERK),

842extraembryonic calcium, 385

FF1-ATPase, 993FoF1-ATP synthase, 993F-actin cortex, 671Factor C, 270fatty acid, 770, 802, 819, 1370fatty acid synthesis, 223faux untranslated region, 39ferredoxin, 1183, 1236ferredoxin reductase, 1183fetal growth, 779FGF (see fibroblast growth factor)FGF-2 (see fibroblast growth factor 2)fibroblast growth factor (FGF), 409, 414,

427, 438, 442fibroblast growth factor 2 (FGF-2), 17fibroblast-like synoviocyte, 727fibrosis, 1119Fisher/Muller model, 560fitness interaction, 560FixLJ-FixK2-NnrR regulatory cascade, 108FlAsH (see fluorescein arsenical helix

binder)flavocytochrome, 1173flexibility, 605FLIM (see fluorescence lifetime imaging

microscopy)fluorescein arsenical helix binder (FlAsH),

498fluorescence lifetime imaging microscopy

(FLIM), 679fluorescence resonance energy transfer

(FRET), 468, 495, 851fluorescent protein, 679fluorophore, 309, 983fluorophore blinking, 979Fn14, 1291FNR (see fumarate and nitrate reductase

regulatory protein)

FNR regulon (see fumarate and nitratereductase regulon)

focal cerebral ischaemia, 1323focal ischaemia, 1261folate, 330folded protein, 971forkhead box O (FOXO), 722, 727, 731forskolin, 492Forster resonance energy transfer (FRET),

679FOXO (see forkhead box O)frameshift protein, 738FRET (see fluorescence resonance energy

transfer; Forster resonance energytransfer)

fumarate and nitrate reductase regulatoryprotein (FNR), 94

fumarate and nitrate reductase regulon(FNR regulon), 104

fungicide, 1219

GGABA (see γ -aminobutyric acid)GABAA (see γ -aminobutyric acidA)GABAA receptor (see γ -aminobutyric acid

type A receptor)GAF domain (see cGMP-specific and

-stimulated phosphodiesterases,Anabaena adenylate cyclases andEscherichia coli FhlA domain)

Gal4p, 794γ -aminobutyric acid (GABA), 868γ -aminobutyric acidA (GABAA), 48γ -aminobutyric acidA receptor interacting

factor-1 (GRIF-1), 48γ -aminobutyric acid type A receptor

(GABAA receptor), 863, 868, 877gankyrin, 746GAP1 (see GTPase-activating protein 1)gating, 899G-CSF (see granulocyte colony-stimulating

factor)GDI (see guanine nucleotide dissociation

inhibitor)GDNF (see glial-cell-line-derived

neurotrophic factor)GEF (see guanine nucleotide-exchange

factor)geminate process, 975gene cluster, 257gene conversion, 535gene expression, 30, 705, 1138, 1141gene expression profiling, 1313gene-expression system, 324gene reassembly, 1236gene regulation, 156, 200, 1062gene regulatory circuit, 328gene transcription, 228genetic code, 328genetic conflict, 562genetic disease, 43genetic exchange, 557genome analysis, 320genome organization, 1133genomics, 247genotype, 560gephyrin, 45

GFAP (see glial fibrillary acidic protein)GFP (see green fluorescent protein)giant fibre circuit, 81GIP (see glucose-dependent insulinotropic

polypeptide)glial-cell-line-derived neurotrophic factor

(GDNF), 458glial development, 663glial fibrillary acidic protein (GFAP), 51, 738gliosis, 51global cerebral ischaemia, 1283GLP-1 (see glucagon-like peptide-1)glucagon-like peptide-1 (GLP-1), 238, 498,

774glucocorticoid, 1018, 1117glucokinase, 238glucose, 247glucose-dependent insulinotropic

polypeptide (GIP), 774glucose homoeostasis, 209, 217glucose metabolism, 806glutamate, 1356glutamate receptor, 927, 949glutamatergic neurotransmission, 64glycine receptor, 45, 55glycine transporter, 55glycoconjugate, 461glycogen phosphorylase, 238glycomics, 435glycosaminoglycan, 409, 422, 435, 446Golgi secretion, 377GPCR (see G-protein-coupled receptor)GPR40 family, 770G-protein, 213, 515G-protein-coupled receptor (GPCR), 435,

484, 770, 942, 1095G-protein receptor kinase-2 (GRK2), 474granulocyte colony-stimulating factor

(GCSF), 1327green fluorescent protein (GFP), 557, 851,

979green oxidation, 304GRIF-1 (see γ -aminobutyric acidA receptor

interacting factor-1)Griscelli syndrome, 671GRK2 (see G-protein receptor kinase-2)growth factor, 454, 833, 1079GTPase, 209, 701GTPase-activating protein, 73GTPase-activating protein 1 (GAP1), 846guanine nucleotide dissociation inhibitor

(GDI), 971guanine nucleotide-exchange factor (GEF),

22, 683, 858

Hhabitat, 169haem, 91, 133, 150, 1173, 1178, 1223haem-copper oxidase, 188haem lyase, 146haemopoietic stem cell, 1327haemoprotein, 1231haem protein, 975Halloween gene, 1256Haloferax mediterranei, 115halohydrin dehalogenase, 291halophile, 115


Subject index 1387

HAMP linker, 111HapMap, 535HCNT1, 130health policy, 1151heart, 232, 489heart failure, 502heat-shock protein 90 (Hsp90), 783heat-shock transcription factor (HSF), 783heparan sulphate, 409, 414, 418, 422, 431,

438, 442, 451, 454, 458, 461heparin, 409, 414, 422, 431, 442, 458hepatocyte growth factor/scatter factor,

414herpes simplex virus (HSV), 705heterogeneous nuclear ribonucleoprotein

AI (hnRNP AI), 17heterologous expression, 894Hey1, 1124hibernation, 1295high-mobility group box 1 (HMGB1), 957hippocampus, 600, 949histidine kinase, 111histidine triad motif (HIT motif), 35histone methyltransferase, 1058HIT motif (see histidine traid motif)HIV, 997HMGB1 (see high-mobility group box 1)hnRNP AI (see heterogeneous nuclear

ribonucleoprotein AI)Holliday junction, 537homoeostasis, 731homologous chromosome pairing, 545homologous recombination, 523, 537,

542horizontal gene transfer, 1165horizontal transference, 97hormonal regulation, 217hormone replacement therapy, 1362host defence, 283hotspot, 526, 535HPV-16 (see human papillomavirus type

16)HSF (see heat-shock transcription factor)Hsp90 (see heat-shock protein 90)HSV (see herpes simplex virus)5-HT (see 5-hydroxytryptamine)5-HT3 receptor (see 5-hydroxytryptamine

type-3 receptor)human 5-HT3 gene, 872human androgen receptor, 1098human aneuploidy, 574human artificial chromosome, 324human genetic variation, 535human genome, 526human papillomavirus type 16 (HPV-16),

1145hyaluronan cross-linking, 446hydrazine, 174hydrogen peroxide, 197hydroperoxide lyase, 1223hydroxylamine, 127hyperthermophile, 118hypertrophy, 228hypoxia/ischaemia, 134720-hydroxyecdysone, 12565-hydroxytryptamine (5-HT), 8725-hydroxytryptamine type-3 receptor

(5-HT3 receptor), 882

IICER (see inducible cAMP early repressor)IKK [see inhibitory κB (IκB) kinase]IL-10 (see interleukin-10)image processing, 983imaging, 851imidazole, 1170immediate early protein, 705immune defence, 257immune pathology, 1032immune response, 1002, 1009, 1028immune system, 1267immunoglobulin (Ig) superfamily, 1024immunomodulation, 476importin, 701, 716imprinting, 1148inclusion, 743incretin hormone, 774inducible cAMP early repressor (ICER), 696infected-cell protein 27 (ICP27), 705inflammation, 446, 727, 965, 997, 1002,

1014, 1018, 1028, 1037, 1119inflammatory lung disease, 276influenza, 1151inhibitor of cytochrome c nitrite reductase,

133inhibitory κB (IκB) kinase (IKK), 1291inhibitory receptor, 1032inhibitory site, 989initiator (Inr), 1047injury, 1356innate immune response, 1018innate immune system, 1024innate immunity, 263, 267, 276inositolphosphorylceramide, 367inositol 1,4,5-trisphosphate (IP3), 228, 515,

922inositol 1,4,5-trisphosphate receptor (IP3

receptor), 910Inr (see initiator)insect genome, 1252insulin, 209, 213, 223, 238, 498, 774, 819insulin secretion, 243, 247, 675, 802, 824insulin-sensitivity, 798integrin, 1261inter-α-inhibitor, 446interceptor, 1005interferon-γ , 461interleukin-6, 1310interleukin-10 (IL-10), 1028internalization, 757internal ribosome entry site (IRES), 17intra-allelic mutation, 581intracellular infection, 283intracellular signalling, 515, 764intracellular targeting, 504intracerebral haemorrhage, 1318intragenomic conflict, 566ion channel, 872, 882ionotropic glutamate receptor, 64IP3 (see inositol 1,4,5-trisphosphate)IP3 receptor (see inositol

1,4,5-trisphosphate receptor)IQ domain, 887IQGAP1, 833IRES (see internal ribosome entry site)ischaemia, 232, 1267, 1295, 1307ischaemia/reperfusion injury, 957

ischaemic injury, 1352ischaemic stroke, 1313islet metabolism, 802isolated enzyme catalyst, 301

JJAK/STAT pathway (see Janus kinase/signal

transducer and activator oftranscription pathway)

Janus kinase/signal transducer andactivator of transcription pathway(JAK/STAT pathway), 1267

jewellery residue, 152JIP [see c-Jun N-terminal kinase

(JNK)-interacting protein]

KKATP channel (see ATP-sensitive potassium

channel)K5 lyase, 438, 451kainate receptor, 949kainate receptor-interacting protein, 927Kaposi’s sarcoma-associated herpesvirus

open reading frame 57 (ORF57)protein, 705

KCNK channel, 899kinase anchoring, 73kinase inhibitor, 1303kinase suppressor of Ras (KSR), 833kinesin, 48kinetic analysis, 1075kinetochore, 711Kir6.2, 243KSR (see kinase suppressor of Ras)

LLa, 12laccase, 304late endosome, 343Lck phosphodiesterase, 476leucocyte, 1002, 1009, 1014, 1024, 1313leucocyte trafficking, 1005leukodystrophy, 22ligand migration, 975ligand-binding domain, 1098lipid, 335lipid dynamics, 399lipid homoeostasis, 363lipid metabolism, 377, 389, 1110lipid trafficking, 346, 395lipopolysaccharide (LPS), 1352lipopolysaccharide-binding peptide, 270lipoprotein, 399, 1370lipoprotein lipase (LPL), 1141lipotoxicity, 819liquid chromatography–MS, 1246live-cell imaging, 983liver, 1119liver X receptor (LXR), 1110, 1128living cell, 679long-term potentiation, 600low-temperature kinetics, 136LPL (see lipoprotein lipase)LPS (see lipopolysaccharide)LXR (see liver X receptor)lymphatic endothelium, 1002lymphocyte, 858


1388 Subject index

Lyp, 1041lysosomal storage disease, 392lysosome, 340, 922

Mmacromolecular assembly, 404macrophage, 1028, 1128magnetic tweezer, 993malate–aspartate shuttle, 811male fertility, 562malonyl-CoA, 223Malpighian tubule, 512MAM (see mitochondria-associated

membrane)mammal, 815mammalian cell, 1079mammalian exocytosis, 687mammalian target of rapamycin (mTOR),

12, 213MAPK (see mitogen-activated protein

kinase)mass spectrometry, 251maternal nutrition, 779matrix adhesion receptor, 1261matrix metalloproteinase-7 (MMP-7), 263ME7, 51mechanical loading, 456mechanotransducer, 456mediator, 304meiosis, 523, 526, 531, 537, 542, 545, 554,

557, 569, 574, 578meiotic arrest, 554meiotic drive, 562, 566MEK (see mitogen-activated protein

kinase/extracellular-signal-regulatedkinase kinase)

melanosome transport, 691membrane association, 160membrane insertion, 504membrane trafficking, 335, 389, 927memory, 504Mendelian segregation, 566MENTAL domain (see MLN64 N-terminal

domain)MENTHO (see MLN64 N-terminal

homologue)metabolic pathway, 1192metabolic syndrome, 798metabolism, 1103metabotropic glutamate receptor, 942MfpA, 317MG1655, 104MHQ (see microsecond

freeze-hyperquench)microaerobiosis, 108microarray, 104, 200microdomain, 374microfabrication, 993microRNA (miRNA), 696microsecond freeze–hyperquench (MHQ),

136microtubule, 550, 687, 716middle cerebral artery occlusion, 1095,

1362mimetic, 461mimicry, 612minichromosome, 324miRNA (see microRNA)

mismatch repair, 542mitochondria-associated membrane

(MAM), 404mitochondrial DNA (mtDNA), 824mitochondrion, 232, 351, 370, 381, 811,

819, 953, 989, 1252, 1283, 1334, 1347mitogen-activated protein kinase (MAPK),

783, 828, 833, 837, 842, 1018mitogen-activated protein

kinase/extracellular-signal-regulatedkinase kinase (MEK), 833

mitosis, 385, 711, 716MLN64, 343MLN64 N-terminal domain (MENTAL

domain), 343MLN64 N-terminal homologue (MENTHO),

343MMP-7 (see matrix metalloproteinase-7)model organism, 43modifier theory, 519molecular architecture, 815molecular biology, 313molecular characterization, 942molecular determinant, 43molecular misreading, 738molecular modelling, 118molten globule, 1054molybdenum, 118mono-nitrosyl non-haem iron complex, 191motif ten element (MTE), 1047moulting, 1256mouse, 605Mre11–Rad50–Xrs2 complex, 523mRNA decay, 35, 39mRNA degradation, 30mRNA translation, 213mRNA turnover, 30mRNA, 12mtDNA (see mitochondrial DNA)MTE (see motif ten element)mTOR (see mammalian target of

rapamycin)mucosal immunity, 273multihaem c-type cytochrome MccA, 146multiple phosphorylation sites, 217multiprotein signalling complex, 438muscarinic receptor, 1037mutational landscape, 560Mycobacterium tuberculosis, 1178myoglobin, 975myosin Va, 671myxothiazol, 139

NNAADP (see nicotinic acid–adenine

dinucleotide phosphate)NADH dehydrogenase, 97NADPH cytochrome c reductase, 1228NADPH oxidase, 960nanoparticle, 427NAP (see periplasmic nitrate reductase)napEDABC genes, 108NarXL regulon, 104NAS (see assimilatory nitrate reductase)natural antisense, 1148nausea, 872N-dealkylation, 304Neisseria gonorrhoeae, 111

Neisseria meningitidis, 139, 197nerve growth factor (NGF), 587, 591, 594,

605, 612nervous system, 77neurodegeneration, 88, 743, 749neurodegenerative disease, 1341neurogenic inflammation, 591neuromuscular junction, 81, 88, 939neuron, 399neuronal differentiation, 1287neuronal necrosis, 1347neuronal survival, 1277, 1287neuropeptide, 591neuroprotection, 936, 1095, 1271, 1310,

1318, 1323, 1327, 1341, 1352neuroprotective drug, 1271neurotransmission, 55, 81neurotransmitter, 77, 863neurotransmitter receptor, 877neurotrophic factor, 1310neurotrophin, 587, 594, 600, 605, 612,

1287neurotrophin receptor, 607, 757neurovascular imaging, 1318NF-κB (see nuclear factor κB)NFAT (see nuclear factor of activated

T-cells)NGF (see nerve growth factor)nicotinamide nucleotide transhydrogenase

(Nnt), 243, 806α7 nicotinic acetylcholine receptor, 1037nicotinic acetylcholine receptor (ACh

receptor), 882nicotinic acid–adenine dinucleotide

phosphate (NAADP), 922Niemann–Pick type C disease, 399NifL–NifA system, 162Nir2, 363nitrate, 104, 111, 127nitrate reductase evolution, 122nitrate respiration, 97, 108nitric oxide (NO), 130, 179, 182, 185, 191,

195, 197, 200nitric oxide reductase, 188, 195nitric oxide synthase, 957nitrification, 179nitrifier denitrification, 179nitrite, 111, 127, 174, 291nitrite reductase, 143nitrogenase, 160nitrogen cycle, 174nitrogen dioxide (NO2), 179nitrogen fixation, 156, 160, 162nitrogen removal, 174nitrosative stress, 197NMDA receptor (see N-methyl-d-aspartate

receptor)NnrR, 94Nnt (see nicotinamide nucleotide

transhydrogenase)NOx cycle, 179non-coding RNA, 1148non-disjunction, 574, 578non-haem-iron protein, 182non-motor domain, 48non-N-methyl-d-aspartate receptor, 64NorR, 191Nrf, 200


Subject index 1389

NrfA, 143, 146nuclear envelope, 340nuclear export, 842nuclear factor κB (NF-κB), 764, 1291nuclear factor of activated T-cells (NFAT),

228nuclear orphan receptor, 1107nuclear pore, 711nuclear pore complex, 701nuclear protein import cycle, 701nuclear receptor, 1089, 1103, 1110, 1341nuclear receptor signalling, 1117nuclear transport, 701, 7055′-nucleotidase, 374nucleotide addition cycle, 1062nucleus–vacuole junction, 340Nudix motif, 35Nur77, 1107nutrient sensing, 770N-methyl-d-aspartate receptor (NMDA

receptor), 55, 877, 936

Oobesity, 770ocr, 317oestrogen, 1362oestrogen receptor β (ERβ), 1114oligaemia, 1295oligodendrocyte precursor, 663oligomerization, 45one-dimensional gel electrophoresis, 1246oocyte, 574ootid competition, 569ORP (see oxysterol-binding-protein-related

protein)OSBP (see oxysterol-binding protein)Osh protein, 356Osh4p, 389ovarian tumour protease, 764OX40, 1032oxidative metabolic profiling, 1241oxidative stress, 197, 806, 824, 960, 1366oxidized metabolite, 1241oxylipin, 1223oxysterol-binding protein (OSBP), 359, 389oxysterol-binding-protein-related protein

(ORP), 3892-oxoacid dehydrogenase, 815

Pp50, 351p53 up-regulated modulator of apoptosis

(PUMA), 727p53, 1283p53, 17p62, 735, 757p75, 607P450 (see cytochrome P450)P450 classification, 1159P450foxy, 1165P450ome, 1165pad3, 1206Paget’s disease of bone (PDB), 735pain, 965pairing centre, 545pancreatic acinar cell, 381pancreatic duodenal homeobox-1 (PDX-1),

791

pandemic, 1151Paneth cell, 263Paracoccus denitrificans, 94, 136, 188paralytic mutant, 81parathyroid hormone, 515parkin, 749parkinsonism, 749Parkinson’s disease (PD), 749partitioning, 1072PASK (see Per-Arnt-Sim kinase)patch–clamp recording, 910pathological phenotype, 872pausing, 1062PCR amplification, 101, 169PD (see Parkinson’s disease)PDB (see Paget’s disease of bone)PDE (see phosphodiesterase)PDE3B (see phosphodiesterase 3B)PDE4 (see cAMP-specific

phosphodiesterase-4)PDGF (see platelet-derived growth factor)PDX-1 (see pancreatic duodenal

homeobox-1)PEGA [see poly(ethylene glycol)

acrylamide]Per-Arnt-Sim kinase (PASK), 791pericellular matrix, 456pericyte recruitment, 454peripheral blood, 1313periplasmic nitrate reductase (NAP), 122perirhinal cortex, 949perlecan, 456permeability transition pore, 232peroxisome-proliferator-activated receptor

(PPAR), 1095, 1341peroxisome-proliferator-activated receptor

α (PPARα), 1128peroxisome-proliferator-activated receptor

γ co-activator-1α (PGC-1α), 1103peroxynitrite, 953, 965PGC-1α (see

peroxisome-proliferator-activatedreceptor γ co-activator 1α)

PH domain (see pleckstrin homologydomain)

phage lambda, 203Phanerochaete chrysosporium, 1165phenobarbital, 1252phenol biodegradation, 165PHO2, 786phorbol ester, 855phosphatase and tensin homologue

deleted on chromosome 10(PTEN)-induced putative kinase 1(PINK1), 749

phosphatidic acid, 363, 395, 504phosphatidylcholine, 377phosphatidylinositol, 363phosphatidylinositol-transfer protein (PITP),

346, 377phosphatidylserine traffic, 404phosphodiesterase (PDE), 468, 480, 484,

495, 510, 512phosphodiesterase 3B (PDE3B), 502phosphoinositide, 647phosphoinositide 3-kinase (PI3K), 12, 722,

727, 731, 851phosphoinositide 3-kinase γ (PI3Kγ ), 502

phospholamban (PLB), 489phospholipase Cγ (PLCγ ), 855phospholipase D (PLD), 346phospholipid, 270phosphoproteome, 59, 1303phosphorylation, 722, 791, 794, 842, 1107,

1299phosphorylation/dephosphorylation, 217photobleaching, 979photosynthesis, 619Photosystem II, 619phytoalexin, 1206phytohormone, 1209PI3K (see phosphoinositide 3-kinase)PI3Kγ (see phosphoinositide 3-kinase γ )PICK1 (see protein that interacts with

protein C-kinase 1)pifithrin-α, 1283PINK1 [see phosphatase and tensin

homologue deleted on chromosome10 (PTEN)-induced putative kinase 1]

PITP (see phosphatidylinositol-transferprotein)

PKA (see protein kinase A)PKB (see protein kinase B)planctomycete, 174plant, 531, 1202plant pathogen, 1219plant steroid hormone, 1199plasma membrane, 68, 910plasmacytoid dendritic cell, 1024plasmid maintenance, 1072plasmid replication, 1072plasmid transfer, 1072platelet-derived growth factor (PDGF), 454PLB (see phospholamban)PLCγ (see phospholipase Cγ )PLD (see phospholipase D)pleckstrin homology domain (PH domain),

647, 846poly(ethylene glycol) acrylamide (PEGA),

309polyamine, 330polyglutamine disease, 738polymorphism, 535, 872, 1186polyunsaturated fatty acid (PUFA), 77postsynaptic density-95 (PSD-95), 877post-transcriptional control, 30post-translational control, 1107post-translational modification, 91, 150,

997potassium channel, 899PPAR (see

peroxisome-proliferator-activatedreceptor)

PPARα (seeperoxisome-proliferator-activatedreceptor α)

preconditioning, 1307pregnane X receptor (PXR), 1119pre-initiation complex, 1051primate evolution, 257prion disease, 51prion protein (PrP), 1155programmed cell death, 1334proNGF, 605propeptide region, 257prostate cancer, 1098


1390 Subject index

prostate cancer therapy, 1124protease, 997protease network, 446proteasome, 76126 S proteasome, 746α1 proteinase inhibitor, 279protein dynamics, 979protein engineering, 301, 435protein film voltammetry, 133protein function, 59protein–glycosaminoglycan interaction, 427protein kinase, 7protein kinase A (PKA), 465, 472, 474, 476,

489, 498, 510, 1299protein kinase B (Akt/PKB), 209, 731, 851,

1295protein kinase CK2, 1303protein misfolding, 43protein phosphatase, 842protein phosphatase type 2C, 1370protein–protein interaction, 162, 317, 679,

971, 1054protein–proteoglycan interaction, 442protein structure, 431protein structure–function, 320protein surface, 431protein synthesis, 12, 328, 600protein targeting, 910protein that interacts with protein C-kinase

1 (PICK1), 931protein tyrosine phosphatase, 1041proteoglycan, 409, 422, 451proteolytic processing, 894proteome, 59proteomics, 1246prothoracic gland, 1256proton-transfer pathway, 188PrP (see prion protein)PSD-95 (see postsynaptic density-95)Pseudomonas, 152Pseudomonas aeruginosa, 185PtdIns(3,4,5)P3, 647PUFA (see polyunsaturated fatty acid)PUMA (see p53 up-regulated modulator of

apoptosis)purine nucleotide biosynthesis, 786PXR (see pregnane X receptor)pyruvate dehydrogenase, 815pyruvate dehydrogenase complex, 217pyruvate dehydrogenase kinase

isoenzyme, 217

Qquartz crystal microbalance-dissipation, 427

RRab, 209, 696Rab27 effector, 691Rab GTPase, 683rabphilin, 691Rab protein, 392Rac1, 855RACE (see rapid amplification of cDNA ends)racemate, 296Raf kinase (see Ras-activated factor kinase)raft, 374Ral, 851Ralstonia eutropha H16, 182

Ran, 701, 716randomized clinical trial, 1323Ran GTPase, 711ranolazine, 238RANTES (see regulated upon activation,

normal T-cell expressed and secreted)rapid amplification of cDNA ends (RACE),

942Ras, 846Ras-activated factor kinase (Raf kinase),

1287RASAL (see Ras-GTPase-activating-like

protein)RasGRP (see Ras guanine nucleotide

releasing protein)Ras-GTPase-activating-like protein (RASAL),

846Ras guanine nucleotide releasing protein

(RasGRP), 858reactive nitrogen species, 953reactive oxygen species, 802, 806, 919,

953, 960, 965receptor-interacting protein 140 (RIP140),

1103receptor tyrosine kinase, 414recognition sequence, 320recombination, 519, 526, 531, 535, 545,

574, 578, 581recombineering, 203recruitment, 1075red fluorescent protein, 557Red Queen hypothesis, 519redox regulation, 162, 919redox shuttle, 811redox signalling, 960redox system, 1178regulated upon activation, normal T-cell

expressed and secreted (RANTES), 422regulation of anaerobic metabolism, 104regulatory system, 200renal epithelium, 512reperfusion, 1366repressor element 1-silencing transcription

factor (REST), 1138respiratory infection, 276respiratory nitrate pathway, 115REST (see repressor element 1-silencing

transcription factor)restricted diffusion, 495restriction, 330restriction endonuclease, 203retention motif, 454retina development, 663retinal precursor, 663rheumatoid arthritis, 727Rhizobium sullae, 130Rho GTPase, 971Rhodobacter capsulatus, 127Rhodospirillum rubrum, 160ribonuclease, 30ribosomal RNA gene, 1079ribosome–mRNA pair, 328riboswitch, 330rifampicin, 1119RIP140 (see receptor-interacting protein

140)RNA polymerase, 1058, 1062, 1067, 1075,

1133

RNA polymerase I, 1079RNA polymerase II, 1047, 1051RNA polymerase III, 1082RNA processing, 1145Robertsonian translocation, 569Robo, 418rolipram, 474root-specific gene, 1192rotary molecular motor, 993rRNA, 1079ryanodine receptor, 370, 919ryanodine receptor mutation, 913

SSaccharomyces cerevisiae, 359sAPPα (see soluble amyloid precursor

protein)sarcoplasmic/endoplasmic-reticulum

Ca2+-ATPase 2 (SERCA2), 489sarcoplasmic reticulum, 919SARS (see severe acute respiratory

syndrome)SAXS (see small angle X-ray scattering)scaffold, 833, 1310scaffolding protein, 472scaffold protein, 828, 837SCP (see sterol carrier protein)scrapie, 1155Sec14 homologue, 377Sec14p, 346second messenger, 495γ -secretase, 607secretory granule, 671, 691secretory leucocyte proteinase inhibitor

(SLPI), 279secretory vesicle, 683, 687segregation distortion, 566selective sweep, 562selenate reductase, 118semi-aerobic growth, 94sepsis, 1028sequestosome 1 (SQSTM1), 735SERCA2 (see

sarcoplasmic/endoplasmic-reticulumCa2+-ATPase 2)

serine- and arginine-rich protein (SRprotein), 1145

serine palmitoyltransferase, 367Set2 Rpb1-interacting domain (SRI

domain), 1058severe acute respiratory syndrome (SARS),

1151sex ratio, 562sexual recombination, 560SHP-1 (see Src homology 2

domain-containing protein tyrosinephosphatase 1)

sialic acid, 1024SIC (see streptococcal inhibitor of

complement)siderophore, 152σ 54 factor, 182, 191, 1067σ factor, 94signalling, 647signalling cross-talk, 798signalling receptor, 461signal transducer and activator of

transcription 3 (STAT3), 1028


Subject index 1391

signal transducing adapter molecule(STAM), 754

signal transduction, 502simulated annealing, 431single-channel recording, 882single molecule, 983single-molecule enzymology, 979single-molecule measurement, 993single stereoisomer, 296Sip4p, 794sirohaem nitrite reductase, 195SL-1 (see splice leader-1)Slit, 418SLPI (see secretory leucocyte proteinase

inhibitor)Slt2(Mpk1)p, 783Smad, 761Smad–ubiquitin regulatory factor (Smurf),

761small angle X-ray scattering (SAXS), 605small GTPase, 846small intestine, 263small ubiquitin-related modifier (SUMO),

1295smooth endoplasmic reticulum, 370smooth muscle, 374Smurf (see Smad–ubiquitin regulatory

factor)SNARE (see soluble

N-ethylmaleimide-sensitive fusionprotein-attachment protein receptor)

SOCS (see suppressor of cytokine signalling)sodium channel, 1299soil micro-organism, 101SOL-1, 64solid-phase synthesis, 309soluble amyloid precursor protein (sAPPα),

1277soluble N-ethylmaleimide-sensitive fusion

protein-attachment protein receptor(SNARE), 683

soluble nitrate reductase, 122somatic cell, 583somatosensory cortex, 949sorting, 757soya bean root nodule, 195sphingolipid, 356sphingolipid biosynthesis, 367spinal bulbar muscular atrophy, 1098spindle, 711, 716spindle assembly checkpoint, 583splice leader-1 (SL-1), 942splice variant, 927splicing, 45Spo11, 523SQSTM1 (see sequestosome 1)squid giant synapse, 68Src homology 2 domain-containing protein

tyrosine phosphatase 1 (SHP-1),1041

SRI domain (see Set2 Rpb1-interactingdomain)

SR protein (see serine- and arginine-richprotein)

STAM (see signal transducing adaptermolecule)

START domain (see steroidogenic acuteregulatory lipid transfer domain)

STAT3 (see signal transducer and activatorof transcription 3)

status epilepticus, 1347Ste7, 837stereoinversion, 287steroid, 1215steroid hormone receptor, 1054steroidogenic acute regulatory

protein-related lipid transfer domain(START domain), 343

sterol 14α-demethylase, 1161sterol �22-desaturase, 1159, 1202sterol carrier protein (SCP), 335sterol trafficking, 356, 359sterol transport, 392stigmasterol, 1202store-operated calcium entry, 910streptococcal inhibitor of complement (SIC),

273streptococci, 273Streptomyces coelicolor, 1183stress response, 7stroke, 1267, 1271, 1291, 1307, 1323,

1362structural biology, 887substrate preference, 1161α2δ subunit, 894subunit positioning, 868subunit specificity, 868subventricular zone, 1310subversion, 273sulphatase, 296sulphonylurea, 243SUMO (see small ubiquitin-related

modifier)superoxide, 197, 965suppressor of cytokine signalling (SOCS),

1267surface chemistry, 309Sushi peptide, 270symbiosis, 156synapse, 43, 59, 64, 877, 931synapsis, 545synaptic function, 43synaptic meiosis, 550synaptic plasticity, 59, 600, 939, 949synaptic transmission, 55, 88synaptic vesicle, 68, 77synaptic vesicle cycle, 81synaptosome, 59synaptotagmin-like protein, 691synchrotron radiation CD spectroscopy, 427syndecan, 418syntaxin, 81synthetic biology, 328

Ttalin, 971TALK channel, 899tandem MS, 1246target membrane soluble

N-ethylmaleimide-sensitive fusionprotein-attachment protein receptor(t-SNARE), 346

TASK-2 channel, 899TATA box, 1047, 1051TATA-box-binding protein (TBP), 1082tauopathy, 88

TB (see tuberculosis)TBP (see TATA-box-binding protein)T-cell, 476T-cell receptor (TCR), 858, 1041TCR (see T-cell receptor)TCSPC (see time-correlated single-photon

counting)telomerase, 581telomere, 550, 581telomere bouquet, 545temperature-gradient gel electrophoresis

(TGGE), 165terminal restriction fragment, 169terpenoid, 1209tether, 683TFIIB (see transcription factor IIB)TGF-β (see transforming growth factor β)TGGE (see temperature-gradient gel

electrophoresis)therapeutic agent, 587therapeutic strategy, 743, 1313therapy, 313thermophile, 97thermophilic haemoprotein, 1170Thermus, 97thiazolidinedione, 1341thiol modification, 919three-dimensional imaging, 675thrombolysis, 1271, 1318, 1323thylakoid membrane, 395time-correlated single-photon counting

(TCSPC), 679tissue plasminogen activator (tPA), 1318TLR (see Toll-like receptor)TNF (see tumour necrosis factor)Tn5 transposition, 320tobacco cell suspension culture, 1241tolerance, 1352Toll-like receptor (TLR), 957, 1352tPA (see tissue plasminogen activator)trafficking, 48, 877, 1128transactivation domain, 1054, 1098transcript elongation, 1062transcription, 115, 786, 1054, 1062, 1072,

1075, 1089, 1148transcriptional activation, 182, 794transcriptional regulation, 185, 783, 1128transcriptional regulator, 794transcription elongation, 1079transcription factor, 696, 791transcription factor IIB (TFIIB), 1047, 1051transcription factory, 1133transcription initiation factor, 1082transforming growth factor-β (TGF-β), 458,

761, 1119, 1141transgenic mouse, 17transgenic plant tissue, 1241translation, 12, 22translational control, 7, 17translation regulation, 22translation termination, 39translocation, 791transmembrane domain, 882transmissible spongiform encephalopathy

(TSE), 1155transporter, 127transporting epithelium, 512transposon, 320


1392 Subject index

trans-Golgi network, 363trial development, 1271triazole, 12192,4,6-trinitrotoluene (TNT), 1228trisomy, 578Trk (see tropomyosin receptor kinase)TrkA (see tropomyosin receptor kinase A)tropomyosin receptor kinase (Trk), 607,

612tropomyosin receptor kinase A (TrkA), 587,

757Trypanosoma brucei, 557trypanosome, 1161TSC (see tuberous sclerosis complex)TSE (see transmissible spongiform

encephalopathy)tsetse fly, 557TSG-6, 446t-SNARE (see target membrane soluble

N-ethylmaleimide-sensitive fusionprotein-attachment protein receptor)

tuberculosis (TB), 283tuberous sclerosis complex (TSC), 213tumour, 722tumour necrosis factor (TNF), 607, 1037,

1352tumour necrosis factor (TNF)-like weak

inducer of apoptosis (TWEAK), 1291tumour suppressor, 633, 746tungsten, 118TWEAK [see tumour necrosis factor

(TNF)-like weak inducer of apoptosis]tyrosine kinase, 1299tyrosine nitration, 965

UUBA domain (see ubiquitin-associated

domain)

ubiquitin, 735, 738, 746, 757ubiquitin-associated domain (UBA domain),

735ubiquitination, 404, 754, 761ubiquitin C-terminal hydrolase, 764ubiquitin–proteasome system, 743ubiquitin-specific processing protease Y

(UBPY), 754UBPY (see ubiquitin-specific processing

protease Y)UDP-glucuronosyltransferase, 1228ultradian rhythm, 1117uncoupling protein, 802unnatural amino acid, 287uracil glycosylase, 317UV irradiation, 7UV–visible spectroscopy, 136

Vvagus nerve, 1037vascular cell type, 731vascular endothelial growth factor (VEGF),

451vasodilator-stimulated phosphoprotein

(VASP), 45VASP (see vasodilator-stimulated

phosphoprotein)vector, 324VEGF (see vascular endothelial growth

factor)vesicle docking, 687vesicle dynamics, 247vesicle fusion, 939vesicle recycling, 68vesicle trafficking, 687vinculin, 971viral mRNA export, 705virus, 1151

voltage-gated calcium channel (CaV), 887,894

voltage-gated l-type calcium channel,903

WWAP domain (see whey acidic protein

domain)water splitting, 619WAVE (see Wiskott–Aldrich syndrome

protein verprolin homologousprotein)

whey acidic protein domain (WAP domain),267

whole-cell biocatalysis, 1215whole-cell catalyst, 301Wiskott–Aldrich syndrome protein verprolin

homologous protein (WAVE protein),73

Wolinella succinogenes, 146

XX-ray crystallography, 1058xenobiotic, 1231xenobiotic metabolism, 1159, 1241

Yyeast, 39, 340, 346, 356, 367, 377, 404,

550, 786, 837, 1058yeast cell integrity, 783

Zzebrafish, 451Zn(II)2Cys6 protein, 794


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index of authors - Home | Biochemical Society Transactions · index of authors A Abe, K ... Barron, R.M. 1155 Bastide, M. 1341 Bazan, N.G. 1277 Belandia, B. 1124 Belﬁeld, E.J. 1223