Index

ABPA, see Aspergillus Acetylcholine, 432, 454 N-Acetyl-,8-D-glucosaminidase, 182, 189 Acid phosphatase, 58, 59 ACTH,608 Actinomycete

antigen, 470-472 mesophilic, 470 thermophilic, 470, 474, 477

ADCC, see Cytotoxicity Adenine, 208 Adenosine deaminase, 280 Adenosine monophosphate, cyclic (cAMP),

15, 115, 124,207-209,213,430,431, 450, 451, 454, 603, 604

Adenosine triphosphatase (ATPase), 199,207, 209,453

Adenovirus, 456, 555 Adenylate cyclase, 124, 208, 430, 453 Adherence of bipolymer, 245 a-Adrenergic

agonist, 402 receptor, hyperresponsive, 452

,8-Adrenergic blockade, 450--452 stimulation, 450

Afferent pathways, 428-430, see also Airway; Lung, receptor

Agranulocytosis, 61, 358 Airway

disease, 251 function, 433, 456 lability, 485 obstruction, 455, 487 resistance, 427,446 size, 424 upper, 428-429

Alkaline phosphatase, 58, 59 Allergen, 139-151,437-440

atopic, 139, 145 contact, 29 drug as, 366-370

Allergen (cont.)

formaldehyde treatment, 598 IgE hypersensitivity, 441 immunotherapy, 594-597 ingested, 365 inhaled, 365 injection therapy, 596 listed, 438, 440 molecular properties, 139-151 primary, 570 response, 233 standardization, 570-571

Allergic

615

asthma, 123, 434-447 bronchopulmonary aspergillosis, see

Aspergillosis contact dermatitis, 21, 25 diseases, 229, 253, 274, 593-613 gastroenteropathy, 333 granulomatous angiitis, 491 infiltrative diseases of the lung

diffuse pulmonary fibrosis, 469 eosinophilic pneumonia, 469 hypersensitivity pneumonitis, 469

pneumonitis, 469, 490 reaction, 355-356

to food, 334, 335 rhinitis, 119-125, 398,406, 593-600

complications, 400 pathophysiology, 399 treatment, 399

Allergy, 22-289 cognitive function, 239-250 drug, 125-127,355-379 family history, 399 food, 333-342 gene for immune response, 272-280 genetics, 229-289 HLA-associated disease, 266-272 immunogenetics, 230-239

clinical, 250--266 insects, 381-395

616

INDEX

Allergy (cont.) management of, 593-613 see also Allergic; Hypersensitivity

Alloantigen, 232 Allogeneic cell, 105

proliferative response to tumor cells, 29 Allograft, renal, rejection of, 35 Allylisopropylacety1carbamine, 357 Aluminum hydroxide, 517 AlveoJitis

extrinsic allergic, 71, 436, 469-484 bird fancier's, 26

idiopathic-fibrosing, 498 American Thoracic Society, 418 Aminophylline, 115, 602, 604, 609 Amish family, 276 Amoeba, free-Jiving, listed, 439 AMP, see Adenosine monophosphate Amphotericin B, 489 Ampicillin, 127, 440 Anaphylatoxin, 17, 198,292,542 Anaphylaxis, 10, 19, 185, 356, 357, 362, 372,

382,383,388,417,443,542,597, 607-609

eosinophil chemotactic factor of, 185-187, 292,442

passive cutaneous (PCA), 586 slow-reacting substance of (SRS-A), 57,

154, 180, 182, 189-193, 213, 292, 442

Anemia aplastic, 358 hemolytic, 358

Angiitis, allergic granulomatous, 491 Angioedema, 291-320, 609-611

causes, listed, 296 diagnostic tests, listed, 300 evaluation, listed, 299 hereditary, 306-310 mediator pathways, 291-296 pressure-induced, 305 vibratory, 306-307

Animal studies, 229, 480 Anthracosis, 499-500 Antibiotic as allergen, 369, see also Penicillin Antibody

affinity, 539 low, 550

antihapten, 166 anti-IgE, 17 anti-IgG, 17 antinuclear, 496, 498, 502, 556 antiruminant, 521 blocking, 583, 596 control, genetic, 247 cytotoxicity, see Cytotoxicity diversity, 233-236 failure to form, 550

Antibody (cont.) fragment and interaction, 141 homocytotropic, 11,26 response, 140 specificity, 141, 548 synthesis, 323 V region, 234-237, 271

Antieosinophilic serum (AES), 76 Antigen, 105, 120, 232, 233, 263, 322, 362,

363, 384-386, 552 antibody complex, 543 antibody ratio, 540 avoidance, 594 bacterial, 552-553 control of stimulus, 229 cross-reactivity, 256 cross-testing, 322 determinant, 139-145, 258-259 E, 174,571,581,587 ethical, 254, 280 food as, 331 la, 96, 99, 101 Ig, 147, 174 in immune complex, 551-557 inhaled,483 lymphocyte-defined, 108 pigeon as, 435, 472 polymorphism, 236-239 serologically defined, 108 synthetic, 234 thymus-independent, 232, 233, 237 valency, 148 viral, 553-555

Antihapten antibody, 166 Antihypertensive agent, 402 Antiidiotype, 236 Apamin, 385 Arachidonic acid, 180, 195 Arthritis, rheumatoid, 70, 71, 496, 539, 559 Arthus response, 26, 362, 487,537,538

diagram, 545 Arylsulfatase, 58, 189, 212, 410, 445 Asbestos bodies, see Asbestosis Asbestosis, 501 Ascaris suum antigen, 166, 422, 446, 447 Aspergilloma, 489, 524 Aspergillosis, allergic bronchopulmonary

(ABPA), 71, 75, 126,485-490, 611-612 Aspergillus

clavatus, 485 j/avus, 486, 488 fumigatus, 436,437,487,488,611 niger, 488 terreus, 488

Aspirin, 369-370 and allergic reactions to drugs, 369 intolerance, 370 sensitivity, 297, 454-455

Aspirylpolylysine, 370 Asthma, 120, 251, 252, 274, 417-467, 485,

491, 600-607 alleqpc, 123,434-447 aspirin-induced, 360 beta-blocking theory of, 120 bronchial, 115,417-467 classification, 419 defined,418 and emotion, 457 exercise-induced, 455 idiopathic, intrinsic, 447-457 lymphocyte subpopulations, 119-125 model canine, 447-448 occupational, 440 and pneumonia, eosinophilic, 485-491 reaction, 434-437 status asthmaticus, 418 and virus infection, 455-456

Asthmatic, corticosteroid-dependent, 600, 602 Ataxia telangiectasia, 516, 519, 521 Atopic

allergy, 11,68-71, 523 diseases, 70-71, 229, 253 eczema, 274 patient, 164

Atopy, 139, 253, 523 familial, 273 see also Atopic

Atrophy idiopathic, 404 in rhinitis, 408

Atropine, 400, 403, 434, 446-450, 455 blockade, 449-500

Autoantibody, 496 Autoimmunity, partial, 361 Azothioprine, 499

Bacteremia, 553 Bacteria, 400, 401, 413, 552

allergy due to, 400, 401, 413 antigen for skin testing, listed, 554

Bagasse, 470, 477 BALT, see Tissue, lymphoid, bronchial­

associated Basement membrane

and rhinitis, 407, 411 thickening of, 420

Basophil, 1-53, 196, 212, 372, 542 chemotaxis, 33, 34 degranulation, see Degranulation electron photomicrograph of, 3

B cell, 31, 87, 88, 91-93, 98, 99, 103, 104, 118, 140, 147, 164, 165, 167, 169,232,236, 363,373,423, 517, 522, 541

Beclomethasone, 451, 489, 607 Bedbug bite, and anaphylaxis, 392 Beekeeper, 386, 387, 390

Bee venom, 390, 570 Benadryl, see Diphenhydramine Benzylpenicilloyl determinant (BPO),

formation of, 368 Berylliosis, 500-501 Beryllium, 500, 501

hypersensitivity to, 500, 501 Biopolymer hydrolase, 243 Biopsy

of gastrointestinal tract, 347-348 of mucosa, 347-348

Bird fancier's extrinsic allergic alveolitis, 26 Birth control pill, 402 Biting insect, see Bedbug bite; Flea; Mosquito Blastomycosis, 502, 503 B lymphocyte, see B cell Bordetella pertussis. 450,517 Bradykinin, 296 Brain stem, 424-425 Brocresine, 180 5-Bromodeoxyuridine. 90, 91 Bronchial

airway. 432-434 asthma, 119-120, 123-125,417-467. see

also Asthma disorders, predominant sites of, 433 responses, listed, 438 smooth muscle, isolated, 453

Bronchiectasis, central, 486 Bronchocentric granulomatosis. 71 Bronchoconstriction, 452-453 Bronchodilator, 434 Bronchomotor modulation, 431-432 Bronchoprovocation, 588 Bronchopulmonary aspergillosis, allergic, 71,

75, 126 Bronchospasm, 447 Busulfan, 492 Buttock, irritation of, 345

Calcium, 16, 206, 207 ionophore, 58

Candida albicans. 117, 118,528,552,553 oral,607

Caplan's syndrome, 499, 500 Carbamylcholine, 120, 452 Carbon tetrachloride. 359 Carbuterol,451 Carcinoma, 298, 299

of colon, 299 of lung, 299 of rectum, 299

Cardiovascular response, 450 Carotid sinus sensitivity. 449 Cat asthma, 601 Cathepsin, 58 Cation, divalent, 206 Caucasian children. 119

617

INDEX

618 INDEX

CBH reaction transferred passively, 32 transferred with T cells, 32

Celiac-sprue malabsorption syndrome, 340 Cell

activation model for, 209 allogeneic, 105

proliferative response to tumor cells, 29 ciliated, 421 endothelial pulmonary, 445 immune infiltrate, 412-413 infiltrate, 408-409

absence of, 408 membrane structure

fluid mosaic model, 201 mesenteric lymph node, 167 sensitivity, 587 surface, self-modification, 271

Central nervous system (CNS), 247-250 cognitive function of, 247 reflexes, 248

Cephalosporin, 366-369 Chang liver cell, 123 Channel, 241 Charcot-Leyden crystal, 419 Chemotaxis

in atopic disease, 124-125 factors in, 67, 68, 107,442 leukocyte, polymorphonuclear, 26 monocyte, 124-125, 529 mononuclear, 530 polymorphonuclear, 124, 125, 530

defective, 125, 523 Chemotherapy, 355 Chest X-ray, 475 Chloramphenicol, 358, 369 Chlorapropamide, 126 Chloroform, 359 Chloromycetin, see Chloramphenicol Chlorprothixene, 364 Cholinergic pathway, 446-447 Cholinergic urticaria, 303, 304 Chondroitin sulfate, 7-9 Chromosome, human, 6, 278 "Chunk" of information, 249, 250 Chymase, 180, 182, 185, 188, 212 Chymotropin, 197 Chymotrypsin, 36, 188, 197 Cigarette smoking, 499 Clara cell, 421 Coagulation pathway, 294 Coal worker's pneumoconiosis, 499,500 Cobra venom, 197

activator of, 18 Coccidiomycosis, 75, 502, 503 Cognitive function, 239-250

central nervous system, 247-250 immune system, 245-247

Cognitive function (cont.) nutrient recognition, 241-244 pollen biology, 244-245

Cognitive mechanism, control of, diagram, 242 Cognitive signal, 240, 242 Colchicine, 209 Colitis, ulcerative, 72 Collagenase, 36, 59 Collagen vascular disease, 298 Colon carcinoma, 299 Colostrum, human, 104 Complement, 17,559,561

anaphylatoxin products, 542 pathways, 292, 293

Compost, 477 Concanavalin A, 16,20, 105, 112, 114, 117,

122, 199, 520 Congestion, 397 Contact dermatitis, 278 Cortex, cerebral, 249 Corticosteroid, 110, 124, 349, 400, 436, 449,

489,497,499,607,609,611,612 therapy, 449

Cortisone acetate, 489 Cough reflex, 424 Cow milk, 332, 338, 340, 348

idiosyncrasy, 338, 356 intolerance of infants to, 332

C-polysaccharide of pneumococci, 559 C-reactive protein in vasculitis, 559-561 Creola bodies, 419 Cromolyn sodium, 126, 348-349, 400, 435,

436, 444, 451, 455, 489 inhalation, 125 therapy, 125

Cryoglobulin, 301 in vasculitis, 556-557

Cryoglobylinemia, 298 CSD, see Asthmatic, corticosteroid-dependent C3b inactivator deficiency, 307 C-type virus, 495 Curschmann spiral, 419 CVA protein, 18 Cyclooxygenase pathway, 195 Cyclophosphamide, 31 Cyproheptadine, 185,302, 312 Cystic fibrosis, 345, 517 Cytochalasin B, 208, 209 Cytoplasma

granules in, 57 see also Degranulation

Cytotoxicity, 92, 108, 114-115, 123 mitogen-induced, 115

Cytoxan, 499

Decongestant, 400 Definition of commonly used terms, 355-356 Degeneracy, 247

Degranulation, to, 17-27,200-207, 2to, 446, 455

of basophil, 19-21 of mast cells, 35, 196-2ll

Demethyltetracycline, 369 Dengue hemorrhagic fever, 74, 555 2-Deoxyglucose, 17 Deoxyribonucleic acid (DNA), 556

antiantibody, viral, 556 Dermacentor andersoni, resistance to, 33 Dermatan sulfate, 8-9 Dermatitis

allergic, 21, 25 atopic, ll6-ll8 pruritic, 525

Dermatomyositis, 497 Dermatophagoides pteronyssimus, 435

sensitivity to, 435 Dermatophytin, 119 Dermographism, 304-305 Desensitization reaction, 374, 594 Determinant

conformational, 143 immunodominant, 144 sequential, 143

Dexamethasone, 599 Dextran, 18, 199 Diabetic, insulin-dependent, 279 Diarrhea

in infant, 338 protracted, 345

Diazoxide, 208 Dicloxacillin, chronic therapy with, 531 Diethylcarbamazine, 490 Di George's syndrome, 91, 514, 519-520 Dimethylsulfoxide, 371 2,4-Dinitrochlorobenzine, 117, 363 Dinitrophenol

derivatives of bovine ')I-globulin, 161 of tuberculosis bacteria, 161, 171

DIP, see Pneumonia, desquamative interstitial Diphenhydramine (Benadryl), 305, 307, 312,

389, 608, 609 Diphtheria toxoid, 119, 279 Disaccharidase deficiency, 333-335 Disodium cromoglycate, see Cromolyn

sodium DNA and immune complex, 555-556 Dog infected with Ascaris, 13 Drug

allergy, 125-127,297,355-379,609 clinical manifestations, 356-361 diagnosis, 370-373 drugs listed, 358-360 factors of patient, 364-366 immunochemistry, 361-366 immunopathology, 361-366 patient's factors, 364-366

Drug (cont.) analgesic, 370 antipyretic, 370 fever, 366 hypersensitivity, see Drug, allergy reactions, see Drug, allergy

Dust, chemical inhalation of, 439 Dysgammaglobulinemia, 518

Ear, human, 240 Eczema, ll5, 346 Edema, 292

angioneurotic, hereditary, 300 or upper airway, 389

Efferent pathway, 425 autonomic nervous system, 426 intercostal nerves, 425-426 phrenic nerves, 425

Electron microscopy, 420 Electron transport

in liver, 360-361 in mitochondria, 360

Elimination diet, 348 Emanation, gaseous, inhalation of, 439 Emotion and bronchial asthma, 457 Emphysema, 418 E myeloma protein, 153-156, 574 Endocarditis, 552

Loeffler's, 494 Endocytosis, 24 Endoperoxidase, 444 Endotoxin, 449 Enterobacter cloacae, 524 Enteropathy, gluten-sensitive, 332, 340, 347,349 Enterovirus, 456 Eosin, 55, 56 Eosinopenia during acute infection, 74 Eosinophil and immunology, 55-86 Eosinophilia, 18,26,27,55-86, 186,212,420

blood, 62 chemotactic factor of anaphylaxis, 66-67,

180, 181, 185-187,292,442 in endocarditis, 72 filarial, 490 function, 68-77 and granuloma of lung, 493, 503 major basic protein (MBP), 69 migration, 64-67 and pneumonia, 484-494 synovial, 72 tropical, 75, 490

and pulmonary vasculitis, 490-491 uterine, 73

Eosinophilopoiesis, 61-64 and T cell, 64

Ephedrine, 604 Epinephrine, 124, 208, 309, 389, 451, 453, 602,

608-610

619 INDEX

620

INDEX

Epithelium, 408, 420 Epstein-Barr virus, 99, 555 Erythema multiforme, 292, 312 Esterase, 103, 472 Estrogen, 405 Exercise and asthma, 455 Exocytosis, 24, 25, 202, 203, 243

Factor B, 97 Familial diseases, 253, 273 Farmer's lung, 470, 475, 478 Feather extract, 480 Fenoterol, 446 Fertilization, 244

response to, 245 Fever, 359-360 Fibrin deposition, 27 Fibronectin, 9 Fibrosis, diffuse pulmonary, 469 Fire ant, 391-392

extract, 392 hypersensitivity, 608 immunotherapy, 392

Flagellin, 89 Flea

bite, 392 immunotherapy, 392

Fletcher factor, deficiency of, 294 Flora of hay, see Hay, microflora Fluorescent bulb workers, 500 Fluoride, 17 Food

allergy, 321-354 as antigen, 594 challenge, 343, 345, 437 dyes in, 298 extract, 346 hypersensitivity, 321-354 idiosyncrasy, 404 intolerance, 337, 338

Formaldehyde treatment of allergen, 598 Fungus ball, 485, 531 Furosemide, 126 Furunculosis, 523 Fusogen, 199

GALT, see Tissue, lymphoid, gut-associated Gangrene, 557 Gastroenteritis, eosinophilic, 494 Gastroenteropathy, acute, 338-340, 345, 347

food intolerance 338-340, 345 Gastrointestinal tract, biopsy of the mucosa,

347 Gene Ir, 365 Genetics of allergy, 229-289 Glomerulitis, proliferative, 498 Glomerulonephritis, 294, 360, 553, 556

Glucagon, 146, 147 Glucocorticosteroid, 453 Glucose-6-phosphate dehydrogenase, 358 Gluten-sensitive enteropathy, 332, 340, 347, 349 Glucogen, 22 /3-Glycerophosphatase, 58 Glucosaminoglycan, 8 Goblet cell, 421 Gold, 493 Goodpasture's syndrome, 497 Granule substance, release of, 24 Granuloma, 479

eosinophilic, 493, 503 Granulomatosis

bronchocentric, 71 Wegner's midline, 404

Granulomatous, chronic, disease of childhood, 517,530

GVHR (graft-vs.-host reaction), 90 Grass pollen, 447

toxin, 594 Griseofulvin, 360 Guanethidine, 402 Guanosine monophosphate, cyclic (cGMP),

115, 207-209, 213, 432, 454 Guanylate cyclase, 453 Guinea pig, 33

Haemophilus injiuenzae, 487, 523 Hageman factor, 294-296, 308, 309

dependent pathways, diagram of, 309 Hand-Schuller-Christian disease, 493 Haplotype effect, 266 Hapten, 139, 147, 361, 364, 437

conjugated, 230 histocompatibility, 365 inhibition, 374 monovalent, 160

Harvester ant, see Pogonomyrmex Hay

fever, 172, 417 microflora, 470

Helix pomatia, 102 Helminthic parasites, 75-77, 298 Helper cell

antigen-specific, 168 isotype, 168

Hemagglutination, 347 Hematological manifestations, 357-358

agranulocytosis, 358 anemia

aplastic, 358 hemolytic, 358

fever, 359-360 hepatic damage, 359 nephropathy, 360 thrombocytopenia, 357-358

Hemocyanin, 32 Heparin

mediator, 187-188 release, 188 sulfate, 7-9, 57,69, 121, 182

Heparinase, 187, 188 Hepatitis, infectious, 298 Hepatitis B (Australian) antigens, 553, 555 Heroin, 493 Herpes simplex type I, 456, 555 HETE,I% Hexamethonium, 449, 493 Hiccup, 424 Histaminase, 445 Histamine, 6-8, 12, 19,36, 69, 109, 141, 142,

154-156, 180, 181, 184, 198,207,212, 294, 385, 386, 430, 440, 447, 449, 542

bronchospasm produced by inhalation of, 441

inhalation, 441 liberator, 198 mediator, 440-442 receptor, 109, 184,454 release, 155, 585-588

assay, 141, 142, 155,207,209,386,430, 440

by ice water, 302 sensitizing factor (HSF), 450 synthesizing capacity, 6-7

Histamine methyltransferase, 184 Histidine decarboxylase, 6, 180 Histiocyte, 493 Histocompatibility, 230

antigen, 231 hapten, 365 major complex, 231

Histoplasmosis, 502, 503 HLA

antigen, 89, 90, 100, 260, 266-270, 272 AW, 32, 269, 270 B,275 B7,268 B8, 268-270, 276 complex loci, 272, 275 D,275 gene, 100, 275 phenotype, 266-268 scratch test, 277 typing, 478

HLA-associated diseases, 266-272 Hodgkin's disease, 68 Honeybee venom, 390, 570 Horse dander, 435 Horseradish peroxidase, 21 House dust

allergy, 594 antigen, 595

HSF, see Histamine, sensitizing factor Hyaluronidase, 385 Hydrochlothiazide, 493 Hydrocortisone sodium hemisuccinate, 609 Hydrolase depolymerizing biopolymers, 243 Hydroxazine (Atarax), 304, 312 5-Hydroxytryptamine, 37, 185 Hydroxyurea, 494 Hydroxyzine hydrochloride, 611 Hymenoptera, winged, stinging insects, 381-391

antibody nature of, 386-387 antigen, nature of, 384-386 body extract, 389-391 clinical aspects, 381-384

diagnosis, 387-388 features, 382 immunopathogenesis, 384-386 reactions, 382-384

anaphylaxis, 383 complications, 384 local, 383 none, 384 toxic, 384

therapy, 388-391 whole body extract, 389-391

Hypereosinophilic syndrome, 72-73, 493 Hyper-IgE syndrome, 522-532 Hyperkinesis, 334 Hypersensitivity

angiitis, 310 and basophil cell, 1-53 cell-mediated, 1-53 chemical, 4-10 contact, 278 cutaneous, 20, 544 and degranulation of basophil, 19-21 delayed onset, 9-20, 25-37, 543 disorders and lymphocyte subpopulations,

87-138 drug, 125-127 food, 321-354 IgE and, 153-177 immediate, 179-228

disorders, diagnosis of, 569-592 mediators of, 179-228 skin test, 572

and mast cell, 1-53 nasal, 397-415 pneumonitis, 436, 469-484, 612 vasculitis, 537-567

histamine-mediated, 551 immune complex, 551-557 rheumatoid factors, 557-559

Hypocomplementemia, 310 Hyposensitization, 349-350, 595

injection therapy for, 349 Hypothalamus, 424

621

INDEX

622

INDEX

Ice cube test for histamine release, 301 Idiosyncrasy, 356 Immediate hypersensitivity disorders,

211-214, 569-592, see also Hypersensitivity

Immidazole, 208 Immune complex, 541

antigens forming, 551-557 bacterial, 552-553 DNA, 555-556 vasculitis lesion, 552-553, 556-557 viral, 553-555

mediated disorders, 71-72, 597 allergic alveolitis, 71 bullous pemphigoid, 71 rheumatoid arthritis, 71 ulcerative colitis, 72

mediated responses, 537-546 Arthus-like, 537-539, 545-546 vascular permeability, 541-545

Immune response and allergic diseases, 274 autoregressive, 271 genes, 272-280

allergen response polymorphisms, 275-278

allergic diseases, 274 infectious diseases, 279-280

genetic control, 231 Immune system, 211-214, 325-328

multivariate analysis, 262-266 Immunity

cell-mediated, 119, 145, 348 concept of two components, 87, see also B

cell; T cell control of, 251 humoral, 122-123 natural, 254

Immunodeficiency disorders, 72-73, 328, 345 and IgE synthesis, augmented, 513-535

Immunodiffusion, 372, 570 radial,574

Immunoelectrophoresis, 372, 570 Immunofluorescence

microscopy, 420 test, 560

Immunogenetics, 230-239 antibody diversity, 233-236 cell cooperation and genetic restriction,

232-233 clinical, 250-266 polymorphism to complex antigen, 236-

239 transplantation biology, 231-232

Immunoglobulin, 123,200, 322, 474, 561 composition, 234 deficiency, 521-522 diseases, 230

Immunoglobulin (cont.J 19A, 93, 119, 122, 557

deficiency, 328 IgD, 95, 96, 102, 548 elevated, 526 and vasculitis, cutaneous, 549

IgE, 10-17,26,60,65,75,92,93, 116, 118, 119, 122, 123, 126, 141, 144, 145, 153-177, 201, 209, 294, 324, 330, 338-341, 372, 385-387, 391, 399, 402, 408,411,412,420,434,445,456, 514, 549,570, 575-582, 585, 587, 588, 593, 595, 596

and allergy, 609 and asthma, 123, 601 and basophil, 11, 12, 159, 160 biosynthesis, 153-177 and degranulation, 14,25,27,203,210 dimer formation, 15 and hypersensitivity, 68, 69, 153-177,441 and immunodeficiency, 513-535 and mast cell, 11, 12,27, 159, 160 measurement, 574-582 reactions mediated by, 160-164 response, 166-172 structure, 158 synthesis, augmented, 515-535

IgG, 11, 13, 59, 60, 92-94, 109, 111, 119, 122, 123, 140-145, 170,338, 339, 341, 347, 366, 390, 548, 551, 557-559, 583-585, 596

IgM, 91-94, 96, 99, 102, 109, 111, 113, 119, 122, 123, 144, 170, 302, 325, 338, 339, 347,420, 548, 557

level in families, 274 prevalence, 335 sensitization, 346 tolerance, 323 and vasculitis, 547

Immunoprophylaxis, 254 Immunotherapy, 583, 584, 596

model,l72 Infectious disease, 74-77, 502-504, 610

eosinopenia, 74 helminthic parasites, 75-77 hepatitis, 298 hypersensitivity in, 279 mononucleosis, 298 pneumonitis, 485 recurrent, 523 rhinitis, 400 schistosoma, 76-77 streptococcal pharyngeal, 550 undetected, 298

Infiltrative pulmonary disease, 469-511 Inflammation, mediators of, 35 Influenza, 457

vaccination, 279, 449

Influenza (cont.) virus

type A, 456 type B, 456

Information processing, 240 INH,126 Inhalation challenge, 476, 588 Inheritance, Mendel's law, 259 Innervation, normal anatomy, 420-434 Insect, 381-395

allergy, 381-395 anaphylaxis, 383 bee, 381 biting, 70, 381-395, 610 bumblebee, 382 honeybee, 382 hornet, 381, 382 sensitivity to, 381-395 stinging, 381-395 venom, 386, 388 wasp, 381, 382 yellow jacket, 381, 382

Insect Committee of the American Academy of Allergy, 389

Insulin, 11, 608 anaphylaxis, 608 bovine, 237

Interferon production, 107 Intolerance, 356 Ionophore, 18, 66, 69, 198 Ir gene, 232, 260

in human families, 262 Isoproterenol, 115, 120, 124, 434, 444, 448,

451,452,454

Jejunum mucosa, 332, 339, 340 Job's syndrome, 525 Jones-Mote phenomenon, 37, 544

Kallikrein, 27, 33, 182, 212, 294, 295, 443-445 K cell, 123, 421 Kinin, 294 Kissing bug, anaphylaxis due to, 392 Kultschitzky-like, see K cell

Lamina propria, 422-423 Lectin, 18, 199 Leprosy, 279

lepromatous, 552 Lesion, leukocytoclastic, 537-567 Letterer-Siwe disease, 493 Leukocyte,56-61,422,453,586

J3-arlrenergic receptor, hypofunction, 456~457

catecholamine receptor, 452 eosinophilic, 56-61

surface receptor, 59-61 factor, 446

Leukocyte (cont.) histamine receptor, hypofunction, 456-457 migration inhibition factor (MIF), 106, 107,

112 phagocytosis, 559 sensitivity, 584, 587 vasculitis, 551

Levamisole, 531 and vasculitis, 551

Lidocaine, 449 Light microscopy, 419-420 Linkage disequilibrium, 272 Lipid chemotactic factor, 183,443 Lipoxygenase pathway, 195 Listeria monocytogenes, 483 Liver damage, 359, see also Hepatitis LMIF, see Leukocyte, migration inhibition

factor Loeffler'S endocarditis, 494

eosinophilic, 72 Loeffler's syndrome, 72-73, 75

anachronism, 491 Lung

abscess, 531 carcinoma, 68, 299 cell suspension and histamine release, 157 nerve supply, 424-430 receptor, 428-430

Lupus erythematosus, 310, 332 spontaneous in mouse, 551 systemic (SLE), 495

Lymphadenopathy 360 Lymphocyte, 87-138, 323, 420, 423

defined, 100 receptor, 94-105 subpopulations

in hypersensitivity disorders, 87-138 listed, 106 markers, 94-105

transformation 120,489 test (LIT), 373

see also B cell; T cell Lymphoid tissue, bronchus-associated, 423 Lymphokine, 18,33,67, 363, 483 Lympholysis, cell-mediated, 108 Lymphoma, 310 Lysolecithin, 199 Lysosome, 243

enzyme release, 452 Lysozyme, 141, 146,410

Macklem's retrograde catheter technique, 432 Macrophage

alveolar, 483 migration inhibition, 373

MALT, see Tissue, lymphoid, mucosal­associated

Malt, moldy, 486

623

INDEX

624 INDEX

Maple bark strippers' disease, 477 Mast cell, 1-53, 196,204,410,420, 542

degranulation, see Degranulation granule, 188-189, 211 subepithelial, 422

Measles, 74 vaccine, 279

Mediator cell, 410-411 control, pharmacological, 430 chemicals, 440-446

listed, 441 of hypersensitivity, 179-228

listed, 181-183 preformed,440-442 production, 120, 189-196 release, 37, 213, 431

Melittin, 385 Membrane, 201-206

calcium content, 198 disorganization, 202 enzymes, bound to, 198 fusion, 201-203 perturbation, 195, 201

Memory, 249 Mendel's law of inheritance, 259 Methacholine, 448, 449 Methadone, 493 Methylsergide, 185,493 Metric model of a trait, 256 Micropolyspora faeni, 436, 437, 472, 474, 478,

479,483 Micropore filter, 33 Microscopy, light, 419-420 Microtubule, 209 MIF (migration inhibition factor), 122, 125,

126, 475, 480, 498 Milk, 104, 365

allergy, 338 antibody, 341 protein, 341, 435

Mimicry, molecular, 270 Mitogen, 105, 115, 120 Mixed connective tissue disease (MCTD),

497 Mixed lymphocyte reaction (MLR), 90 Model, mathematical, for inherited trait,

255-256 Modulating agent, 207-209 Mold spore, 398

as antigen, 595 Moldy

barley, 486 hay, 470, 472, 474

Monoamine oxidase, 184 Mononucleosis, infectious, 298 Moro response, 248, 249 Mosquito, 392

Mucin, 472 Mucosa

as barrier, 325-328 biopsy specimen, 333

Mucus, 419 gland,423

Multiple sclerosis, 269, 270, 272 Multivariate methods

for genetic markers, 264 for immune response, 264

Mumps, 106, 107, 119 Mutation, somatic, 235 Myelocyte, 56 Myeloma protein E, 153-156, 574 Myeloperoxidase. 58, 61 Myoglobin of sperm whale, 239 Myxovirus, 456

NADPH oxidase, 59 a-Naphthylacetate esterase (ANAE), 103 Nasal

disease, 398-411, see also Rhinitis, allergic evaluation, 407 hypersensitivity, 397-415, see also Rhinitis,

allergic mastocytosis, 410-411 membrane histopathology, 407-408, 475 mucosa, evaluation of, 407 pain, 397 polyp, 405

Necrosis, acute tubular, 360 Neoplasia, 73-74

carcinoma, 73-74 eosinophilia, radiation-related, 73 Hodgkin's disease, 73 leukemia, eosinophilic, 73 sarcoma, 73-74

Nephritis, 497 NephropathY, 360 Nerve

autonomic system, 426 ending, 426 intercostal, 425-426 parasympathetic, 426 phrenic, 425 sympathetic, 426

Nervous system autonomic, 426 defective, nonadrenergic, inhibitory, 454

Neuraminidase, 99 Neurectomy, vidian, 403 Neuroepithelium, 422 Neutrophil, 18, 58, 59, 61, 67, 212

chemotactic factor (NCF), 185-187,442 New Guinea, thatched roof disease in, 473 Nezelof's syndrome, 514, 520-521 Nippostrongylus brasiliensis, 12, 162, 165,

516

Nitrofurantoin, 473, 492 eosinophilia, 126 pneumonitis, 126 syndrome, 126

Nocardia as mitogen, 106 Norepinephrine, 402 Nucleoside phosphorylase, 521 Nucleotide, cyclic

interaction, 454 in leukocytes of atopic patients, 124

Nuts, 609 Nystatin, 489

Occupational diseases, 499-502 anthracosis, 499-500 asbestosis, 501-502 berylliosis, 500-501 silicosis, 499-500

Organ vagotonia, 417 Ovalbumin, 161, 169, 174 Overdosage, 355 Oxazolidine, 360

PAF, see Platelet-activating factor Para-group drugs, 364 Parasites, 298, 299, 334, 517

and eosinophilia, 299 see also separate parasites

Pemphigoid, bullous, 71 Penicillin

allergy, 297, 360-373 anaphylaxis, 356, 357, 366, 374 therapy, 70

Peptide determinant, 142 eosinophilotactic, 187

Periarteritis, 553 Permeability, vascular, 543, 544 Peroxidase, 58, 61 Phagocytosis, 59, 243 Phenacetin, 370 Phenetidin, 371 Phenobarbital, 126 Phenothiazine, 364 Phentolamine dibenzamine, 453 Phenylephrine, 120,599 Phenylketonuria, 253 Phenylthiocarbamide, 273 Phosphatase

acidic, 58, 59 alkaline, 58, 59

Phosphodiesterase, 124 Phospholipase, 69, 197,204,205,296,445,570

A, 197, 204, 205, 570 B,445 C,206 D, 69, 445 in insect venom, 385

Phytohemagglutinin (PHA), 89-91, 112, 117, 120,520

Pigeon breeder's disease, 470, 473, 475, 479,

480 dropping extract, 472, 478, 479 serum as antigen, 436, 472, 478

Pinocytosis, 243 P-K, see Prausnitz-Kiistner Plasma cell, 423 Plasmin, 212 Platelet, 543

aggregation, 452 cyclooxygenase, 68 lipoxygenase, 68

Platelet-activating factor (PAP), 69, 180, 183, 193-194, 292, 442

Platinum, 440 Pneumococcus

C-polysaccharide, 559 pneumonia, 251, 489

Pneumoconiosis of coal workers, 499, 500

Pneumocystis carinii, 73,75,520 Pneumonia, 523

desquamative interstitial, 494 eosinophilic, 436, 469, 484-494

drugs for, 492-493 with asthma, 485-491 without asthma, 491-494

hemorrhagic, 497 interstitial

desquamative, 494 usual,494

pneumococcal, 251, 487 Pneumonitis

allergic granulomatous, 469, 490 chronic, 340-341 food, 345, 480 hypersensitivity, 436, 469-484, 612 infectious, 485

Pogonomyrmex maricopa, 392 rugosus, 392

Poisons, 334 Pokeweed, 121

as mitogen, 165 Pollen, 417

airborne, 594 allergy, 121 antigen, 597 grain, 244

Pollenosis, 586 Polyarteritis, 490, 491 Polylysine, 146 Polymorphism, 246, 271, 280

genetic, 246 hypothetical, 271

625

INDEX

626

INDEX

Polymorphism (cant.) immune, 246 transducer, 246, 249

Polymorphonuclear inflitrate, 413 Polymyositis, 497 Polymyxin B, 18 Prausnitz-Kiistner (P-K)

reaction, 153, 154,326,327,330,571,574 test, 327, 586

Precipitation, 347 Prednisone, 1l0, 488, 599, 605, 606, 608, 611,

612 Prick test, 572 PRIST, 577 Probability analysis by genetic methods, 280 Procaine, 357

anaphylaxis due to, 357 Procarbazine, 473 Properdin pathway, 293 Prophylaxis, 350, 374 Propranolol, 431, 449, 450, 453 Prostacyclin, 445 Prostaglandin, 180, 183, 192-196, 297, 370,

444-445, 454 E, 195,455 hypothesis, 454

Prostaglandin synthetase, 192, 297 Protease, 8, 36 Protein

of body, 384 major basic (MBP), of eosinophil, 69 nitrogen unit (PNU), 570

Proteoglycan, 7-10 Provocation test

fatal, 373 by inhalation challenge, 476

Proxyphene, 493 Psychogenic factors, 300 Pulmonary airway cells, 420-422 Pulmonary disease, infiltrative, 469-511

eosinophilia (PIE), 484, 494 fibrosis, 469 gold-induced, 493 Ig features, 469-511

Pulmonary eosinophilia, 484, 493, 494 with granuloma, with neoplasia, 493-494

Pulmonary fibrosis, 494-504 connective tissue disease, 495-499 Goodpasture's syndrome, 497-498 idiopathic fibrosing alveolitis, 498-499 polymyositis, 497 PSS,4% rheumatoid arthritis, 496-497 SLE, 495-496

Pulmonary function test, 476 Pulmonary hemosiderosis, 504 Pulmonary vagotonia, 450 Pyrazolone derivatives, 370

Quadrachamber, 63

Radioallergosorbent test (RAST), 142, 330, 346, 372, 385, 386, 570, 571, 575, 579-582, 584, 586, 588

inhibition, 570, 571 interpretation, 580-582

Radioimmunoassay (RIA) double antibody, 577 IgG specific, 583 solid phase, 574

Radioimmunosorbent test (RISn, 575-578, 588

Ragweed antigen, 14, 153, 154, 161, 166, 174

E, 121, 122, 161, 166, 174,570 patient allergic, 586 pollen, 122, 147, 398

extract, 573 pollenosis, 596 rhinitis, 70 season, 599

RAST, see Radioallergosorbent test Rat parasite, see Nippostrongylus brasiliensis Raynaud's phenomenon, 557 Reagin, ll, 70, 153, 324, 336, 574

mediated reaction, 325, 335-337, 344-346 nonmediated reaction, 337-342, 347-348 sensitization, 328-331, 336, 346 skin test, 328-329 see also Immunoglobulin, IgE

Rebuck skin window, 529 Receptor, 102-104, 232

on cell surface, 242 hyperresponsive a-adrenergic, 452 irritant, 428, 429 mobile receptor hypothesis, 201

Rectum, carcinoma of, 299 Reflex, simple, 248, 430 Regression, multivariate, 263 Reproduction in plants, control of, 244 Reserpine, 402 Respiratory tract, upper, infection, 552 Rheumatoid

arthritis, 70, 4%, 559 factor, 496, 498, 502, 539, 557-559

Rhinitis, 397-415 allergic, 119-125, 398-400, 406, 593-600 atrophic, 408 chemical, 405 chronic, 413 food, 404 hormonal, 404, 409 infectious, 400-401 intrinsic, 413 lesion, 402-403 medicamentosa, 401, 402, 409, 599 neurogenic, 403, 409

Rhinitis (cont.) nonatopic, 400-401 perennial, 398-400 polyps and, 405-406 of pregnancy, 402 psychosomatic, 406 ragweed. 70 vasomotor, 401, 409

Rhinorrhea, 397 Rhinovirus, 457 RhLA haplotype, 260-262 Rhus extract, 117 Ribonuclease, 58 Rifampicin, 126,473 RIST, see Radioimmunosorbent test Rosette formation oflymphocytes, 98, 101,

452 autorosette, 102, 103 inhibition, 101 technique, 32, 59-60

Rous sarcoma virus, 29 Rubella, 74, 106, 107 Rye grass, 570

Salbutamol, 402, 403, 440 Salmonella

lipopolysaccharide, 236 strassbourg, 236

Scarlet fever, 74 Schistosoma mansoni, 63,76-77,516

in mouse, 64 Schistosomula, 76 Sclerosis, progressive systemic (PSS), 496 Seafood,608 Secondary mediator, see Mediator Sedormid, 357 Self versus nonself, 241, 243 Sensitization

induction, 361 nonreaginic, detection of, 331-333

Septicemia, gonococcal, 552 Septum, deviated nasal, 402 Serine esterase, 14, 15, 197,204

activation, 15 inactivation, 15

Serine protease, 472 Serotonin, 8, 69, 180, 181, 185,443-445,447 Serum

antibody, 347 antieosinophilic (AES), 76 see also Antibody

Serum sickness syndrome, 310, 357 Silica dust exposure, 499 Silicosis, 499-500 Skin allograft, 29 Skin testing, 336, 487, 571-573

for food allergy, 329, 331, 346 for milk protein allergy, 341

Skin window technique, 330 SK-SD, see Streptokinase-streptodornase SLE, see Lupus erythematosus, systemic Slow-reacting substance of anaphylaxis

(SRS-A), see Anaphylaxis Smooth muscle cell, 423-424, 427, 432 Soap powder, 405 Sodium azide, 58 Solenopsis

invicta, 391-392 richteri, 391-392

Soy protein, 332 Sperm whale myoglobin, 239 Splenocyte, 90 Squamous cell epithelium, 408 Staphylococcus aureus, 58, 487, 517, 523

nuclease, 144, 237-239 protein A, 106

Status asthmaticus, see Asthma f3-Stimulator, 402 Stimulus recognition, 240 Streptococcal pharyngeal infection, 550 Streptokinase-streptodornase (SK-SD), 118,

119 Streptomycin, 369 Sulfonamide, 369, 492 Sulfur dioxide, 405 Surface receptor, see Receptor Sweat response, eccrine, 450 Syndrome, see separate syndromes

Tartrazine yellow #5, 298 T cell, 25, 31, 35, 37, 62, 63, 87-90,102-115,

119, 120, 140, 146, 147, 164-170, 173, 232,236,323,363,373,423,452,517, 520, 522, 541

TIL cell, 1l0-1l5 Ty cell, 1l0-1l5 Tension fatigue, 334 Terbutaline, 451 Tetanus toxoid, 63, 117, 119, 528 Tetracycline, 369 Tetrapeptide, 65 Theophylline, 208, 451 Therapy, 373-374, 388-391, 400

avoidance, 388 hyposensitization, 374, 400 medical, 388-389 nonspecific, 400 prophylaxis, 374

Thatched roof disease of New Guinea, 473 Thrombocytopenia, 357-358 Thromboxane A, 183, 192, 195 Thromboxane synthetase, 195 Thymic

dysfunction, 521 dysplasia, 520 hypoplasia, 520

627

INDEX

628

INDEX

Thymocyte, 102 Thymopoietin, 110 Thymoxamine, 453 Thymus, development of, 89, see also Thymic Tissue

damage, 539 incompatibility, 245 lymphoid

bronchial-associated (BALT), 105 gut-associated (GALT), 105 mucosal-associated (MALT), 105

T lymphocyte, see T cell Tolerance, 323 Toluene diisocyanate (TDI), 440 Tooth extraction, 553 Toxin, 334 Toxocara canis, 447 Trait, inherited, mathematical mode's for,

255-256 Transducer mechanism, 246 Transfer factor, 531 Transplantation biology, 230-232 Trichinella spiralis, 62, 63, 76 Trypsin, 36 Tuberculin, 31, 209

delayed hypersensitivity, 29 Tuberculosis

bacteria, 499 inheritance, 273

Tumor cell, allogeneic, 29 Tyrosine-p-azobenzenearsonate, 146

Urticaria, 291-320, 609-611 causes, listed, 300-310 cholinergic, 303, 304 evaluation, listed, 299-300

Vaccinia virus, 29 Vagus, 427 Varicella, 74 Vascular permeability, 543, 544 Vasculitis, 298, 541, 550, 551, 560-562

C-reactive protein, 559-561 and cryoglobulin, 556-557 cutaneous, 539 hypersensitivity, 537-567 investigations, 546-551 pulmonary, 490-491

Venom, 384, 385 apamin, 385 hyaluronidase, 385 immunotherapy, 390 melittin, 385 phospholipase, 385 polypeptide, 18

Virus as antigen, 553-555 C-type, 495 in respiratory tract disease, 456 see also separate viruses

V region of antibody, see Antibody

Wading and hypotension, 302 Wegener's midline granulomatosis, 404 Wheat, 348 Whole body extract of Hymenoptera, see

Hymenoptera Wiskott-Aldrich syndrome, 514, 518-519 Writing on skin, ability of, 304

Zinc, 8 Zymosan, 58, 66, 294