837

INDEX

Volume 234, July-September 1985

A23187aorta contraction and (rats), 443leukotriene release and, lung parenchyma,

217

Abel, P. W., see Nasseri, A., 350Abernethy, D. R., Greenblatt, D. J., Ameer,

B. and Shader, R. I.: Probenecid im-pairment of acetaminophen and br-azepam clearance: Direct inhibitionof ether glucuronide formation, 345

Abraham, R. T., Benson, L. M. and Jardine,I.: Influence of hepatic oxidative me-tabolism on the immunosuppressiveactivities of 6-thiopurines, 670

Abuse liability

nicotine, intravenous and inhaled, 1triazolam us. pentobarbital, 120

Acetaminophenclearance, probenecid impairment of, 345

hepatic necrosis induced by, cimetidine

and N-acetylcysteine treatment(rats), 550

Acetazolamide, electrolyte reabsorption, in-

hibitory effect, kidney tubules (dogs),

747

N-Acetylation, polymorphism, genetics,liver (hamster), 358

Acetylcholineend-plate receptor-channel complex, ed-

rophonium, physostigmine and

methanesulfonyl fluoride interac-

tions with (snakes), 5395-hydroxytryptamine and, calcium chan-

nels activated by, coronary artery

(cows), 641

3H-labeled, release, dopamine regulationof, stomach (guinea pigs), 713

motility stimulated by, cyclooxygenase in-hibit.or effects, colon (rats), 742

nonadrenergic bronchodilation and

(cats), 590

Acetylcholinesterase, inhibition, end-platereceptor-channel complex (snakes),

539N-Acetylcysteine, cimetidine and, acet-

aminophen -induced hepatic necrosis(rats), 550

N-Acetyltryptamine, melatonin, receptor,retina (rabbits, chickens), 395

Action potentialcalcium-dependent, dynorphin effects

(mice), 49prolongation, (k.n#{252}�ra toxins and, ax-

ons (crayfish), 307

Adenosine, cardiac effects, atrial and yen-tricular preparations (guinea pigs),766

S-Adenosylmethionine, isoproterenol 0-methylation, aorta (rabbits), 184

Adenylate cycbase, norepinephrine-coupledgenerating system, imipramine andadrenocorticotropin effects on, brain(rats), 409

Adrenoceptoralpha adrenergic

nimodipine effects, saphenotss vein(dogs), 598

postjunctional, intermediate auricularartery (dogs), 698

alpha-i, antagonists, cardiovascular re-flexes (dogs), 456

alpha-i and aLpha-2, peripheral circula-

tion (dogs), 728a�pha-2, saphenous vein contractions, cal-

cium role (dogs), 161Adrenocorticotropin, imipramine and, nor-

epinephrine-coupled cyclic nucleo-tide generating system, brain (rats),409

Age, [3Hjouabain binding, digitalis recep-tore and, skeletal muscle (guinea

pigs), 720Agonist-antagonist interactions, opiate,

three-key drug discrimination proce-dare (pigeons), 81

Airways, nonadrenergic relaxation, neurallymediated, cholinergic mechanismsand (cats), 590

Albuminalpha-i acid glycoprotein and, prazosin

and antipyrine elimination, liver(rats), 636

serum

enzyme-albumin conjugates, chronic

administration (mice), 250polyacryl starch microparticles trap-

ping, immune response (mice), 255Alkadhi, K. A., see Lokhandwala, M. F., 337Allen, T. M., Murray, L., Bhardwaj, D. and

Poznansky, M. J.: cs-Glucosidase-al-bumm conjugates: Effect of chronicadministration in mice, 250

Altiere, R. J., Szarek, J. L. and Diamond,L.: Neurally mediated nonadrenergicrelaxation in cat airways occurs in-

dependent of cholinergic mecha-nisms, 590

Ambrose, J. M., see Silver, P. J., 629

Ameer, B., see Abernethy, D. R., 345

Amine, biogenic, drug-induced changes,brain (rats), 141

p-Aminobenzoic acid, N-acetylation, ge-

netic differences, liver (hamster), 358-y-Aminobutyric acid

antagonists, vasopressin release stimula-tion by (rats), 378

vagal afferent stimulation, sympatheticnerve inhibitory response, effects on(cats), 288

-�-Aminobutyric acid-benzodiazepine chan-nel antagonists, supraspinal convul-sions (rabbits), 274

L-(aS,5S)-a-AminO-3-chlOrO-4,5-dihy-

dro-5-isoxazoleacetic acid, methyl-mercury urinary excretion, effects on(mice), 156

Aminoglycoside

nephrotoxicity, endotoxemia and (rab-bits), 425

renal excretion, nephrectomy and (dogs),90

N-(6-Aminohexyl)-5-chloro- 1 -naphtha-lenesulfonamide, anticahnodulinproperties, artery (rats, rabbits), 476

6-Aminolevulinic acid dehydratase, inhibi-tion by lead, reversal by renal lead-binding protein (rats), 365

Ammonium, quaternary compounds, a�pha-1 acid glycoprotein, binding to, 703

Amnesia, triazolam vs. pentobarbital ef-fects, 120

D-Amphetamine, tetrahydrobiopterin andbiogenic amine concentrations,changes induced by, brain (rats), 141

Analgesia, thiorphan and (rats), 386Anaphylaxis

mediators, collateral ventilation, lung pa-riphery (dogs), 491

slow-reacting substance of, leukotrienereceptors and, lung (guinea pigs), 316

Anemia, hemolytic, propylthiouracil toxic-ity (cats), 13

Angiotensin converting enzyme, pulmonary,

inhibition (rabbits), 372Anion transport, specific inhibition, gossy-

pol and erythrocyte membrane func-tion, 575

Antagonist, see specific type

Antibiotics, nephrotoxicity, endotoxemiaand (rabbits), 425

Antibody, antinuclear, drug-induced (cats),13

Antidepressantsbeta adrenergic receptor/N-protein cou-

pling, cerebral cortex (rats), 30forced swim and, beta adrenergic receptor

down-regulation (rats), 402Antipyrine

elimination, albumin and a�pha-1 acidglycoprotein effects, liver (rats), 636

metabolism, hypoxia and pregnancy ef-fects on, liver (rats), 584

Aortacalcium channels, bepridil hydrochloride

effects (rabbits), 63

contraction inhibition, SQ 29,548 effects(rats), 435

contraction mechanism, calcium ionchannels and phospholipase C (rats),443

isoproterenol, 0-methylation of (rabbits),184

APP-201-533, vascular and cardiac con-tractile protein function, effects on(cows, dogs), 629

Arachidonic acidinfusion, prostaglandin E� and renin

release (dogs), 261

metabolism, diabetes mellitus and (rats),211

metabolites, beta adrenergic responsive-

ness and, coronary artery (cows), 555

Araki, K., see Iwainoto, K., 470Arginine vasopressin, protein phosphoryla-

838 Index Vol. 234

tion mediated by, urinary bladder(toads), 515

AR-L 115 BS, positive inotropic effect, yen-tricular muscle (dogs), 267

Artursson, P., Edman, P. and Sj#{246}holm,I.:Biodegradable microspheres II: Im-mune response to a heterologous andan autobogous protein entrapped inpolyacryl starch microparticles, 255

Asano, M. and Hidaka, H.: Pharmacolog-ical properties of N-(6-aminohexyl)-5-chboro- 1 -naphthalenesulfonam-ide(W-7), a calmodulin antagonist inarterial strips from rats and rabbits,476

Aslanian, W. A., see Wedlund, P. J., 662

Aspirin, antihypertensive effect, inhibition

by metoprolol (rats), 166

Asthma, leukotrienes and, lung (guineapigs), 316

AT-125, see L-(aS,5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

Atriumadenosine effects (guinea pigs), 766supersensitivity (rats, guinea pigs), 280

Atropine, nonadrenergic noncholinergic re-laxation, airway (cats), 590

Aucoin, D. P., Peterson, M. E., Hurvitz, A.I., Drayer, D. E., Lahita, R. G.,Quimby, F. W. and Reidenberg, M.M.: Propylthiouracil-induced im-

mune-mediated disease in the cat, 13Auricular artery, intermediate, postjunc-

tional alpha adrenoceptors in (dogs),698

Axon, Goniopora toxin effects on (crayfish),307

Azathioprine, immunosuppression, hepaticoxidative metabolism influence on

(mice), 670

Bahouth, S. W. and Musacchio, J. M.: Spa-cific binding of [3Hjsubstance P to

the rat submaxillary gland. The ef-facts of ions and guanine nucleotides,326

Band 3, gossypol interaction with, erythro-cyte membrane function and, 575

Banziger, V., see Tuttle, R. S., 166

Barakeh, J. F., see Nasseri, A., 350

Barbital, chronic, dependence, abstinenceeffects, cerebellar cyclic GMP system(rats), 569

Barbituratedependence, abstinence effects, cerebellar

cyclic GMP system (rats), 569pentobarbital, triazolam us., 120slow outward current, alterations induced

by (mollusks), 821Barone, S., see Head, R. J., 184

Barorefiex, sympathetic nerve inhibitory re-sponse, vagal afferent stimulation, -y-aminobutyric acid mediation (cats),288�

Barrett, J. E., see Brady, L. S., 106

Bartobome, M. B., see Kuhn, C. M., 204

Behaviorantidepressants and forced swim, beta ad-

renergic receptor down-regulation

(rats), 402locomotor activity, hyperbilirubinemia

and cerebellar proteins (rats), 522nicotine, cocaine and metabolites, effects

on (dogs, monkeys), 106

phencyclidine withdrawal (rats), 415

punished, shock termination and food

presentation (monkeys), 106

self-mutilation, dopamine receptors,functional supersensitivity (rats),447

tolerance, escape titration and (monkeys),94

Bennett, B. M., Brien, J. F., Nakatsu, K.

and Marks, G. S.: Role of hemoglobinin the differential biotransformationof glyceryl trinitrate and isosorbidedinitrate by human erythrocytes, 228

Benowitz, N., see Simon, R. P., 830

Benowitz, N. L. and Jacob, P., III: Nicotinerenal excretion rate influences nico-tine intake during cigarette smoking,153

Benson, L. M., see Abraham, R. T., 670Benzodiazepine

antagonists, supraspinal convulsions in-

duced by (rabbits), 274triazolam, pentobarbital us., 120

Ben-Zvi, Z., see Garty, M., 391Bepridil hydrochloride

antiarrhythmic and electrophysiologic ef-fects, myocardal ischemia and infarc-tion (dogs), 72

calcium channels, effects on, vascular

smooth muscle of aorta (rabbits), 63Berti, F., see Sautebin, L., 217Bethanechol, nonadrenergic noncholinergic

relaxation, airway (cats), 590Bhardwaj, D., see Allen, T. M., 250B-HT 920, nimodipine and, saphenous vein

(dogs), 598Bicuculline, vasopressin release stimulated

by (rats), 378Bladder, protein phosphorylation, vasopres-

sin-mediated (toads), 515Blanquet, F., Bouvier, M. and Gonella, J.:

Action of trimebutine in cat and rab-bit colon: Evidence of an opioid-likeeffect, 708

Blockade, reticuloendothelial, enzyme-al-bumin conjugates, chronic adininis-tration effects (mice), 250

Blood flow, liver, propranobol clearance, car-bon tetrachloride effects (rats), 470

Blood pressuredopamine and bromocriptine effects, neu-

ronal and postjunctional componentsof (rabbits), 681

sympathetic nerve inhibitory response,vagal afferent stimulation, �y-amino-butyric acid mediation (cats), 288

Bone, mobilization, glucopyranoside effects(rats), 25

Bone marrow, cell cycle kinetics, alterationby diphenylhydantoin (mice), 57

Boorman, G. A., see Tucker, A. N., 57Bouvier, M., see Blanquet, F., 708Bowman, K. F., see Riviera, J. E., 90

Boyd, M. R., see Kramer, R. A., 498Boyer, I. J., Cory-Slechta, D. A. and Di-

Stefano, V.: Lead induction of cropdysfunction in pigeons through a di-rect action on neural or smooth mus-cle components of crop tissue, 607

Boyer, I. J. and DiStefano, V.: An investi-gation of the mechanism of lead-in-duced relaxation of pigeon cropsmooth muscle, 616

Brady, L. S. and Barrett, J. E.: Effects ofserotonin receptor antagonists on

punished responding maintained by

stimulus-shock termination or food

presentation in squirrel monkeys,106

Brainmarijuana binding sites (rats), 784muscarinic cholinergic receptors from,

[3H]pirenzepine binding to (rats), 37pentylenetetrazol concentrations, infu-

sion rate effects on, convulsions(rats), 624

phenobarbital uptake, blood-brain pHgradient influence on, status epilep-ticus (rats), 830

Branch, R. A., see Wedlund, P. J., 662Breese, G. R., Napier, T. C. and Mueller, R.

A.: Dopamine agonist-induced loco-motor activity in rats treated with 6-hydroxydopamine at differing ages:

Functional supersensitivity of D-1dopamine receptors in neonatally le-sioned rats, 447

Breese, G. R., see Duncan, G. E., 402

Brian, J. F., see Bennett, B. M., 228Broadley, K. J., MacLeod, K. M., Rodgers,

R L. and McNeil, J. H.: Regionaldifferences in the responses ofguinea-pig cardiac tissue to carbacholand their potentiation by hypother-mia, 222

Bromocriptine, blood pressure effects, neu-ronal and postjunctional components(rabbits), 681

Bronchodilation, nonadrenergic, acetylcho-

line and (cats), 590

Brouwer, K. L. R and Vore, M.: Effect ofhypoxia and pregnancy on antipyrinemetabolism in isolated perfused ratlivers, 584

Brown, J. A., see Marrazzi, M. A., 804Bruckner, R, Fenner, A., Meyer, W., Nobis,

T.-M., Schmitz, W. and Scholz, H.:Cardiac effects of adenosine andadenosine analogs in guinea-pigatrial and ventricular preparations:Evidence against a role ofcyclic AMPand cyclic GMP, 766

Buthionine sulfoximide, 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-ni-trosourea nephrotoxicity, effects on(rats), 498

Caffeine, calcium overload induced by, re-versal, Purkinje fibers (dogs), 172

Calciumantagonist

vascular and cardiac contractile proteinfunction, effects on (cows, dogs), 629

vasodepressor effects (dogs), 728conductance, kappa opioid effects (mice),

49dopamine release dependent on, mela-

tonin and, retina (rabbits, chickens),395

entry blocker, alpha adrenergic activationinhibition, saphenous vein (dogs),598

extracellular, saphenous vein contrac-tions and, a�pha-2 adrenoceptors(dogs), 161

fluxes, W-7 effects, vascular smooth mus-cle (rats, rabbits), 476

overload, caffeine-induced, reversal, Pur-kinje fibers (dogs), 172

surface membrane bound, displacement,skeletal muscle (frogs), 233

Index 8391985

transport, glucopyranoside effects (rats),25

Calcium channelacetylcholine- and 5-hydroxytryptamine-

activated, coronary artery (cows), 641

antagonist, myocardial calcium and p0-tassium channel blocking (frogs), 134

blockers, beta receptors, heart, 561potential-dependent and receptor-oper-

ated, bepridil hydrochloride effects,vascular smooth muscle ofaorta (rab-bits), 63

Calcium ionionophore A23187, leukotriene release

and, lung parenchyma, 217

voltage-dependent channels, 5-hydroxy-tryptamine receptor-mediated aorta

contraction (rats), 443

Calmodulinantagonist, N-(6-aminohexyl)-5-chloro-

1-naphthalenesulfonamide (rats,rabbits), 476

vascular and cardiac contractile proteinfunction (cows, dogs), 629

Cannabinoid, binding sites, brain (rats), 784

Cannabis, binding sites, brain (rats), 784

Caporali, M. G., see Massotti, M., 274Captopril, angiotensin converting enzyme

inhibition induced by, kinetics (rab-

bits), 372

Carbachol, cardiac tissue responses to, po-tentiation by hypothermia (guineapigs), 222

Carbon tetrachloride, chronic, reduced he-patic propranolol clearance (rats),

470Cardiotonics, vascular and cardiac contract-

ile protein function, effects on (cows,dogs), 629

Cardiovascular system

contractile proteins, calcium antagonisteffects on (cows, dogs), 629

dopamine receptors, SKF 82526 and

(dogs), 337

reflex tachycardia, alpha-i adrenoceptorantagonists (dogs), 456

renal nerve activity suppression, methio-nine enkephalin (rabbits), 534

Carter, R. B. and Dykstra, L. A.: Effects ofpicenadol (LY150720) and its ster-eoisomers on electric shock titrationin the squirrel monkey, 299

Cassis, L. A., see Goto, K., 280

Cassis, L. A., Stitzel, R. E. and Head, R. J.:Hypernoradrenergic innervation ofthe caudal artery of the sponta-neously hypertensive rat: An influ-ence upon neuroeffector mecha-nisms, 792

Catalepsy, met.aphit effects on (pigeons),

648

Catecholamine, detection, atrium (rats,guinea pigs), 280

Catechol-0-methyltransferase, isoprotere-

nol and, aorta (rabbits), 184

Caudal artery

hypernoradrenergic innervation, sponta-neous hypertension (rats), 792

postjunctional supersensitivity, reser-pine-induced, alpha adrenergic recep-tors and (rats), 350

Cell cycle, kinetics, bone marrow, alterationby diphenylhydantoin (mice), 57

Central nervous system, see Nervous system

Cephalosporin, nephrotoxicity, endotox-emia and (rabbits), 425

Cerebellumcyclic GMP, barbital tolerance develop-

ment, subsequent abstinence and,cerebellum (rats), 569

hypoplasia, bilirubin neurotoxicity and

(rats), 522Cerebral cortex

beta adrenergic receptor/N-protein cou-pling, clenbuterol and antidepressantdrugs (rats), 30

cyclic GMP, barbital tolerance develop-ment, abstinence effects, cerebellum(rats), 569

Cerebrospinal fluid, pentylenetetrazol con-centrations, infusion rate effects on,convulsions (rats), 624

Chiba, S., see Ito, T., 698Chimeric toxin, binding, cholinergic neuro-

muscular junction (mice), 100

1-(2-Chloroethyl)-3-(trans-4-methylcyclo-

hexyl)-1-nitrosourea, nephrotoxicity,buthionine sulfoximime effects on(rats), 498

Chuang, D.-M., see Nakaki, T., 442

Cigarette smoking

abuse liability and pharmacodynamiccharacteristics, 1

nicotine intake, renal clearance and, 153Cimetidine, N-acetylcysteine and, acet-

aniinophen-induced hepatic necrosis(rats), 550

Cinnarizine, vascular and cardiac contract-ile protein function, effects on (cows,dogs), 629

Cirazoline, nimodipine and, saphenous vein

(dogs), 598Cisapride, motor-stimulating properties,

gastrointestinal (guinea pigs), 775

Clark, M. A., see Mong, S., 316Clausen, T., see Kjeldsen, K., 720Clenbuterol, beta adrenergic receptor/N-

protein coupling, cerebral cortex

(rats), 30Clonidine

a’pha adrenoceptors and, intermediate

auricular artery (dogs), 698

kappa opioids vs. , diuresis and vasopressinsuppression (rats), 463

tolerance, escape titration and (monkeys),94

Cocaine

behavioral effects (dogs, monkeys), 106

tetrahydrobiopterm and biogenic amineconcentrations, changes induced by,brain (rats), 141

Colonelectromyogram, trimebutine effects

(cats, rabbits), 708motility, cycbooxygenase inhibitor effects

(rats), 742Cone, E. J., see Risner, M. E., 113

Conn, P. J. and Sanders-Bush, E.: Seroto-nm-stimulated phosphoinositideturnover: Mediation by the S� bind-ing site in rat cerebral cortex but notin subcortical regions, 195

Contraception, gossypol, erythrocyte mem-

brane function and, 575Contractile force, caffeine-induced calcium

overload, Purkinje fibers (dogs), 172Convulsion

pentylenetetrazol infusion rate and, se-

rum, brain and cerebrospinal fluid(rats), 624

spontaneous, barbital tolerance develop-ment, abstinence effects, cerebellarcyclic GMP system (rats), 569

supraspinal, benzodiazepine antago-nist-induced (rabbits), 274

Cooke, J. P., Rimele, T. J., Flavahan, N. A.and Vanhoutte, P. M.: Nimodipineand inhibition ofa�pha adrenergic ac-tivation of the isolated canine saphe-nous vein, 598

Copeland, J., see Simon, R. P., 830

Corn, R. E., see Haspel, H. C., 575Coronary artery

arachidonic acid metabolites in, beta ad-renergic responsiveness and (cows),555

calcium channels, acetylcholine- and 5-hydroxytryptamine-activated (cows),

641

Corticotropin releasing factor, tetrahydro-biopterin and biogenic amine concen-trations, changes induced by, brain(rats), 141

Cory-Slechta, D. A., see Boyer, I. J., 607

Costa, E., see Nakaki, T., 442

Cotinine, behavioral effects (dogs, mon-keys), 106

Crivellari, M. T., see Sautebin, L., 217Crooke, S. T., see Mong, S., 316Crop

neural or smooth muscle components,

lead-induced dysfunction (pigeons),607

smooth muscle, lead-induced relaxation(pigeons), 616

Current, slow outward, barbiturate-induced

alterations (mollusks), 821Cyclic AMP

bilirubin neurotoxicity, cerebellar pro-teins and (rats), 522

cardiac effects, atrial and ventricularpreparations (guinea pigs), 766

norepinephrine-coupled generating sys-tem, imipramine and adrenocortico-tropin effects on, brain (rats), 409

phosphodiesterase inhibition, ventricular

muscle (dogs), 267SQ 29,548 effects, platelets (humans,

guinea pigs, rats), 435vasopressin-mediated protein phosphor-

ylation and, urinary bladder (toads),515

Cyclic GMPbarbital tolerance, development, subse-

quent abstinence and, cerebellum(rats), 569

bilirubin neurotoxicity, cerebellar pro-

teins and (rats), 522cardiac effects, atrial and ventricular

preparations (guinea pigs), 766Cycbooxygenase

beta adrenergic responsiveness and, ar-achidonic acid metabolite effects on,coronary artery (cows), 555

inhibitors, Met-enkephalin- and acetyl-choline-stimulated motility, effectson, colon (rats), 742

SQ 29,548 effects, platelets (humans,guinea pigs, rats), 435

Cytochrome P-450, inhibition, cimetidine

effects, acetaminophen-induced hep-atotoxicity (rats), 550

840 Index VoL 234

Dachiw, J., see Silver, P. J., 629Dawson, J. R., Weitering, J. G., Mulder, G.

J., Stillwell, R. N. and Pang, K. S.:Alteration of transit time and direc-

tion of flow to probe the heteroge-neous distribution of conjugating ac-tivities for harmol in the perfused ratliver preparation, 691

De Cou#{235}t,G., see Dumont, M., 239Deguchi, N., see Iwamoto, K., 470de la Lande, I. S., see Head, R. J., 184

Desmopressin

diuresis and, kappa opioids (rats), 463peroral, diabetes insipidus, 754

Diabetes insipidus, peroral treatment, des-mopressin, 754

Diabetes mellitus, arachidonic acid metab-olism, urinary prostaglandin andthromboxane excretion (rats), 211

Diamond, L., see Altiere, R. J., 590

Digitalis receptors, see ReceptorDigoxin

3H-labeled, binding, digitalis receptors

and, skeletal muscle (guinea pigs),720

renal clearance, spironolactone effects(dogs), 190

Dihydroergotamine, liver uptake, trolean-domycin effects (rats), 239

Diltiazem

calcium channels, effects on, vascularsmooth muscle of aorta (rabbits), 63

vasodepressor effects (dogs), 728verapamil and, coronary artery contrac-

tion (cows), 641

Dimethylpropranolol, ventricular muscles,electrophysiobogy (guinea pigs), 507

DiMicco, J. A., see Wible, J. H., Jr., 378Diphenylhydantoin, bone marrow cell cycle

kinetics, alteration by (mice), 57DiStefano, V., see Boyer, I. J., 607DiStefano, V., see Boyer, I. J., 616Diuresis, vasopressin suppression and,

kappa opioids (rats), 463

Diurnal rhythms, tetrahydrobiopterin andbiogenic amine concentrations, drug-induced changes, brain (rats), 141

Domino, E. F., see Koek, W., 648

Domperidone[3H]acetylcholine release, dopamine reg-

ulation of, stomach (guinea pigs), 713

dopamine and, blood pressure (rabbits),681

Dopamine[3Hjacetylcholine release, regulation by,

stomach (guinea pigs), 713blood pressure effects, neuronal and post-

junctional components (rabbits), 681calcium-dependent release, melatonin

and, retina (rabbits, chickens), 3956-hydroxy, locomotor activity and, flee-

nate and adult (rats), 447receptors, see Receptor

Dorsal root ganglion neuron, action poten-tial duration, dynorphin and neoen-dorphin peptide effects (mice), 49

Drack, E., see Scheurer, U., 742Drayer, D. E., see Aucoin, D. P., 13Drug abuse

nicotine, abuse liability and pharmaco-dynamic characteristics, 1

triazolam vs. pentobarbital, 120Drug dependence

agonist-antagonist interactions (pigeons),

81

barbital, abstinence effects, cerebellarcyclic GMP system (rats), 569

phencyclidine (rats), 415

Drug discrimination, lysergic acid diethyl-amide, serotonin agonists and antag-onists (monkeys), 244

Drug metabolism, polymorphic, mepheny-thin, normal subjects, 662

Drug tolerance, methadone, neuroendocrinefunction and (rats), 204

Dubocovich, M. L.: Characterization of aretinal melatonin receptor, 395

Duman, R. S., Strada, S. J. and Enna, S. J.:Effect of imipramine and adrenocor-ticotropin administration on the ratbrain norepinephrine-coupled cyclicnucleotide generating system: Alter-

ations in a4.�ha and beta adrenergic

components, 409Dumont, M., De Cou#{235}t,G., Le Bigot, J.-F.

and Erlinger, S.: Mechanism of up-take of dihydroergotamine by iso-lated rat hepatocytes: Effect of tro-leandomycin, 239

Duncan, G. E., Paul, I. A., Harden, T. K.,Mueller, R. A., Stumpf, W. E. andBreese, G. R: Rapid down regulationof beta adrenergic receptors by corn-bini’ng antidepressant drugs withforced swim: A model of antidepres-sant-induced neural adaptation, 402

Dykstra, L. A., see Carter, R B., 299

Dynorphincalcium-dependent action potential du-

ration, effects (mice), 49infusion into substantia nigra, maximal

electroshock seizure protection(rats), 45

Ear, artery, a4�lza adrenoceptors in (dogs),698

Edman, P., see Artursson, P., 255

Edrophonium, physostigmine and methane-sulfonyl fluoride, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539

Edvinsson, L., see Wahlestedt, C., 735Effeney, D. J., see Wasehek, J. A., 431Ekblad, E., see Wahlestedt, C., 735Electrical control activity, migrating my-

oelectric complex, morphine, intes-tine (dogs), 814

Electrical field stimulation, airways (cats),590

Electrical response activity, migrating my-oelectric complex, morphine, intes-tine (dogs), 814

Electrolyte, reabsorption, acetazolamide in-

hibitory effects, kidney tubules(dogs), 747

Electromyogram, trimebutine effects, colon(cats, rabbits), 708

Electroshockseizure, protection, opiate infusion into

substantia nigra (rats), 45titration, picenadol effects (monkeys),

299

Enalapril, angiotensin converting enzymeinhibition induced by, kinetics (rab-bits), 372

Endoh, M., Yanagisawa, T., Morita, T. andTaira, N.: Differential effects of sul-mazole (AR-L 115 BS) on contractileforce and cyclic AMP levels in canine

ventricular muscle: Comparison withMDL 17,043, 267

Endotoxemia, antibiotic nephrotoxicityaugmentation by (rabbits), 425

Endotoxin, renal injury and, antibioticnephrotoxicity (rabbits), 425

Enkephalin, cycbooxygenase inhibitors and,interaction, colon (rats), 742

Enkephalinase A, thiorphan and analgesia(rats), 386

Enna, S. J., see Duman, R. S., 409Ensinger, H., Majewski, H., Hedler, L. and

Starke, K.: Neuronal and postjunc-tional components in the blood pros-sure effects of dopamine and bromo-criptine in rabbits, 681

Epilepsy, opiate infusion into substantia ni-gra and (rats), 45

Erlinger, S., see Dumont, M., 239Erythrocyte

glyceryltrinitrate and isosorbide dinitratebiotransformation, hemoglobin rolein, 228

membrane function, gosaypol effects on,575

Escape titration, drug tolerance and (mon-keys), 94

Eulie, P. J., see Rhee, H. M., 534

Evanich, M. J., Sander, G. E, Rice, J. C.and Giles, T. D.: Ventilatory re-sponse to intravenous methionine

enkephalin in awake dogs, 677

Fenner, A., see Bruckner, R., 766

Ferguson, R. J., see Hein, D. W., 358

Fibrillation, ventricular, bepridil effects

(dogs), 72Fiekers, J. F.: Interactions of edrophonium,

physostigmine and methanesulfonylfluoride with the snake end-plate ace-tylcholine receptor-channel complex,539

Fielding, R. M., see Wasehek, J. A., 431Fiori, F., see #{248}ie,S., 636Flaim, S. F., Ratz, P. H., Swigart, S. C. and

Gleason, M. M.: Bepridil hydrochlo-ride alters potential-dependent andreceptor-operated calcium channelsin vascular smooth muscle of rabbitaorta, 63

Flaim, S. F., see Ratz, P. H., 641

Flavahan, N. A., see Cooke, J. P., 598Fleming, W. W., see Goto, K., 280

Fluorescence, catecholamine detection,atrium (rats, guinea pigs), 280

Folate, bone marrow cell cycle kinetics and,diphenyihydantoin effects (mice), 57

Folco, G., see Sautebin, L., 217Forced swim test, antidepressants and, beta

adrenergic receptor down-regulation

(rats), 402Fowler, B. A., see Goering, P. L., 365

France, C. P. and Woods, J. H.: Opiateagonist-antagonist interactions: Ap-plication of a three-key drug discrim-ination procedure, 81

Frank, G. B., see Shetty, S. S., 233Fraser, A., see O’Donnell, J. M., 30Frederickson, R. C. A., see Mendelsohn, L

G., 386Fujiwara, M., see Muramatsu, I., 307

�9-Funaltrexamine, vasopressin suppressionand (rats), 463

Gale, K., see Garant, D. S., 45

1985 Index 841

Galli, G., see Sautebin, L., 217Garant, D. S. and Gale, K.: Infusion of

opiates into substantia nigra protects

against maximal electroshock sei-zures in rats, 45

Garty, M., Ben-Zvi, Z. and Hurwitz, A.:Opioid effects on lidocaine disposi-tion and toxicity in mice, 391

Gastrointestinal tract, cisapride, motor-

stimulating properties (guinea pigs),775

Gatta, F., see Massotti, M., 274Gawronska-Szklarz, B., see Rane, A., 761

Genetics, N-acetylation differences, liver(hamster), 358

Gentamicin, decreased fractional renal ex-cretion, nephrectomy and (dogs), 90

Gibson, T. P., see O’Brien, M. S., 190

Gibes, T. D., see Evanich, M. J., 677Gillis, C. N., see Moalli, R., 372Gleason, J. G., see Mong, S., 316Gleason, M. M., see Flaim, S. F., 633fi-D-Glucopyranosides, vitamin D com-

pounds, biologic activity (rats), 25a-Glucosidase-albumin, conjugates, chronic

administration, effects (mice), 250

Glucostat, “gold thioglucose-lesioned,” thio-glucose and, interactions (mice), 804

Glucuronidation, inhibition, probenecid,345

Glutathionebiosynthesis, 1-(2-chloroethyl)-3-(trans-

4-methylcyclohexyl)- 1 -nitrosoureaeffects, buthionine sulfoximide and(rats), 498

reduced, leukotriene formation and, lungparenchyma, 217

urinary excretion, L-(aS,5S)-a-aminO-3-chloro-4,5-dihydro-5-isoxazoleacetic

acid effects (mice), 156Glyceryl trinitrate, biotransformation by

erythrocytes, hemoglobin role in, 228Glycoprotein

alpha-i acid, prazosin and antipyrineelimination, liver (rats), 636

alpha-i acid and asialo a�pha-1 acid, cat-ion binding, 703

Glycoside, vitamin D analogs, biologic ef-fects (rats), 25

Goering, P. L. and Fowler, B. A.: Mecha-nism of renal lead-binding proteinreversal of �-aminolevulinic acid de-hydratase inhibition by lead, 365

Goldberg, S. R., see Risner, M. E., 113Gold thioglucose, glucostat lesioned by,

thioglucose and, interactions (mice),804

Gonella, J., see Blanquet, F., 708

Goniopora toxin, axons, effects on (cray-fish), 307

Gosselin, R. E., see Weselcouch, E. 0., 19Gossypol, erythrocyte membrane function,

effects on, 575Goto, K., Longhurst, P. A., Cassis, L. A.,

Head, R. J., Taylor, D. A., Rice, P. J.and Fleming, W. W.: Surgical sym-pathectomy of the heart in rodentsand its effect on sensitivity to ago-nists, 280

Grassi, E., see Sautebin, L., 217Greenberg, R., see Ogletree, M. L., 435

Greenblatt, D. J., see Abernethy, D. R., 345

Griffiths, R. R., see Roache, J. D., 120Gross, M., see Londowski, J. M., 25

G-substrate, bilirubin neurotoxicity and(rats), 522

Guanine, nucleotides, [3H]substance Pbinding, submaxillary gland (rats),326

H#{224}kanson, R., see Wahlestedt, C., 735Haloperidol, [3H]acetylcholine release, do-

pamine regulation of, stomach(guinea pigs), 713

Halter, F., see Scheurer, U., 742

Hammer, M. and Vilhardt, H.: Peroraltreatment of diabetes insipidus witha polypeptide hormone analog, des-mopressin, 754

Hansen, 0., see Kjeldsen, K., 720

Harden, T. K., see Duncan, G. E., 402Harmol, conjugation, transit time and flow

direction alteration, effects on, liver

(rats), 691Harris, D. N., see Ogletree, M. L., 435

Hart, J. C., see Leander, J. D., 463

Hartmann, A., see Langberg, H., 747Hashish, cannabinoid binding sites, brain

(rats), 784Haslanger, M. F., see Ogletree, M. L., 435Haspel, H. C., Corin, R. E. and Sonenberg,

M.: Effect of gossypol on erythrocyte

membrane function: Specific inhibi-tion of inorganic anion exchange andinteraction with band 3, 575

Head, R., see Koek, W., 648Head, R. J., Irvine, R. J., Barone, S., Stitzel,

R. E. and de la Lande, I. S.: Nonin-tracellular, cell-associated 0-meth-ylation of isoproterenol in the iso-

lated rabbit thoracic aorta, 184

Head, R. J., see Cassis, L. A., 792Head, R. J., see Goto, K., 280

Heartbeta-i and beta-2 adrenergic receptors, co-

existence in, 561carbachol effects, potentiation by hypo-

thermia (guinea pigs), 222digitalis receptors, [3Hjouabain distribu-

tion (guinea pigs), 720electrophysiology, myocardial Ca� and

K� channel blocking (frogs), 134Purkinje fibers, see Purkinje fibersrate, urapidil and prazosin effects (dogs),

456sympathectomy, sensitivity to agonists

and (rats, guinea pigs), 280transcapillary solute transport (rabbits),

19ventricles

adenosine effects (guinea pigs), 766contractile force and cyclic AMP levels

(dogs), 267electrophysiology, dimethylpropranobol

effects (guinea pigs), 507tachycardia and fibrillation, bepridil ef-

fects (dogs), 72Hedberg, A., Kempf, F., Jr., Josephson, M.

E. and Molinoff, P. B.: Coexistenceofbeta-i and beta-2 adrenergic recep-tors in the human heart: Effects oftreatment with receptor antagonistsor calcium entry blockers, 561

Hedler, L., see Ensinger, H., 681Hedlund, R, see Simon, R P., 830

Hem, D. W., Kirlin, W. G., Ferguson, R. J.and Weber, W. W.: Biochemical in-vestigation ofthe basis for the genetic

N-acetylation polymorphism in theinbred hamster, 358

Hemicholinium, nonadrenergic inhibitorysystem, lung (cats), 590

Hemoglobin, biotransformation, organic ni-trates, 228

Henningfield, J. E., Miyasato, K. and Jas-inski, D. R.: Abuse liability and phar-macodynamic characteristics of in-travenous and inhaled nicotine, 1

Hepatocyte, dihydroergotamine uptake, tro-leandomycin effects (rats), 239

Hepatotoxicity, acetaminophen, cimetidineand N-acetylcysteine effects (rats),550

Hexamethonium, nonadrenergic noncholin-ergic relaxation, airway (cats), 590

Hidaka, H., see Asano, M., 476Hisaoka, M. and Levy, G.: Kinetics of drug

action in disease states. XIII. Effectof dialyzable component(s) of uremicblood on phenobarbital concentra-tions in rats at onset of loss of right-ing reflex, 180

Histamine

airway reactivity to (dogs), 491capillary permeability and, myocardium

(rabbits), 19receptors, see Receptor

Hoffman, B. B., see Lurie, K. G., 147

Holsztynska, E. J., see Koek, W., 648

Hong, L., see Thcker, A. N., 57Howell, R. E., see Moalli, R., 372

Hsu, C.-Y., see Tune, B. M., 425Huguenard, J. R. and Wilson, W. A.: Bar-

biturate-induced alterations in thekinetic parameters of slow outwardcurrent in Aplysia giant neurons, 821

Hume, J. R.: Comparative interactions oforganic Ca� channel antagonistswith myocardial Ca4� and K� chan-nels, 134

Humphrey, S. J. and McCall, R. B.: Evi-dence for �y-aminobutyric acid media-tion of the sympathetic nerve inhib-itory response to vagal afferent stim-

ulation, 288Hurvitz, A. I., see Aucoin, D. P., 13Hurwitz, A., see Garty, M., 391Hydrolysis, phosphoinositide, serotonin-

stimulated (rats), 1956-Hydroxydopamine, see Dopamine5-Hydroxytryptamine, see Serotonin

Hyperbiirubinemia, cerebellar proteins and(rats), 522

Hyperinnervation, caudal artery, sponta-neous hypertension and (rats), 792

Hypersensitivity diseases, leukotriene re-

ceptors and smooth muscle contrac-tion, lung (guinea pigs), 316

Hypertension

spontaneous

aspirin antihypertensive effect, meto-probol inhibition of (rats), 166

hypernoradrenergic innervation, caudal

artery (rats), 792Hypoplasia, cerebellar, bilirubin neurotox-

icity and (rats), 522Hypothermia, cardiac tissue response to

carbachol, potentiation by (guineapigs), 222

Hypoxia, pregnancy and, antipyrine metab-olism, liver (rats), 584

Imipramine

842 Index Vol.234

adrenocorticotropin and, norepinephrine-coupled cyclic nucleotide generatingsystem, brain (rats), 409

forced swim and, beta adrenergic receptordown-regulation (rats), 402

Immune function, bone marrow cell cyclekinetics, diphenylhydantoin effects(mice), 57

Immune response, trapped protein (mice),255

Indomethacin, beta adrenergic responsive-ness, arachidonic acid metabolite ef-fects on, coronary artery (cows), 555

Infarction, myocardial, bepridil effects(dogs), 72

Intestine

absorption, desmopressin and diabetes in-sipidus, 754

migrating myoelectric complex, biphasic

response to morphine (dogs), 814Inulin, permeability-surface area products,

transcapillary transport, myocar-dium (rabbits), 19

Ions, [3Hjsubstance P binding, effects on,submaxillary gland (rats), 326

Iprindole, forced swim and, beta adrenergicreceptor down-regulation (rats), 402

Irvine, R. J., see Head, R. J., 184Ischemia, myocardial, bepridil effects

(dogs), 72

Isometric tension, bepridil hydrochloride,effects on calcium channels, vascularsmooth muscle of aorta (rabbits), 63

Isoniazid, N-acetylation, genetic differ-

ences, liver (hamster), 358

Isoproterenol, capillary permeability and,myocardium (rabbits), 19

Isosorbide dinitrate, biotransformation byerythrocytes, hemoglobin role in, 228

Ito, T. and Chiba, S.: Existence of two typesof postjunctional a�pha adrenocep-

tors in the isolated canine interme-diate auricular artery, 698

Iwamoto, K., Watanabe, J., Araki, K., Se-toh, M. and Deguchi, N.: Reducedhepatic clearance of propranolol in-duced by chronic carbon tetrachlo-ride treatment in rats, 470

Jacob, P., III, see Benowitz, N. L., 153

Jacobson, A. E., see Koek, W., 648Jacqz, E., see Wedlund, P. J., 662

Janasen, P. A. J., see Schuurkes, J. A. J.,775

Jardine, I., see Abraham, R. T., 670Jasinski, D. R., see Henningfield, J. E., 1

Jim, K. F. and Matthews, W. D.: Role of

extracellular calcium in contractionsproduced by activation of postsyn-aptic a�pha-2 adrenoceptors in thecanine saphenous vein, 161

Johnson, B. G., see Mendelsohn, L. G., 386Josephson, M. E., see Hedberg, A., 561

Junction potentials, colon electromyogram,trimebutine effects (cats, rabbits),708

Kadowitz, P. J., see Spannhake, E. W., 491

KB-944, vasodepressor effects (dogs), 728Kempf, F., Jr., see Hedberg, A., 561

Kidneydigoxin clearance, spironolactone effects

(dogs), 190

disease, aminoglycoside excretion, ne-phrectomy and (dogs), 90

failure, phenobarbital and uremia (rats),180

lead-binding proteins, �-aminolevulinic

acid dehydratase inhibition reversal(rats), 365

nephrotoxic injury, antibiotics and (rab-bits), 425

nicotine clearance, nicotine intake and,153

prostaglandins E,� and E�, metoprolol andaspirin antihypertensive effects(rats), 166

tubules, electrolyte reabsorption, acet-azolamide inhibitory effects (dogs),

747

Kiil, F., see Langberg, H., 747

Kiil, F., see Vikse, A., 261Kinzig, C. M., see Mong, S., 316Kirlin, W. G., see Hem, D. W., 358Kjeldsen, K., N#{248}rgaard, A., Hansen, 0. and

Clausen, T.: Significance of skeletalmuscle digitalis receptors for[3Hjouabain distribution in the

guinea pig, 720Kleeberger, S. R., see Spannhake, E. W.,

491Klingman, G. I., see Spain, J. W., 415Kodama, I., Kondo, N., Shibata, S. and Ya-

made, K.: Effects of dimethylpro-

pranolol (UM-272) on the electro-physiological properties of guinea-pigventricular muscles, 507

Koek, W., Head, R., Holsztynska, E. J.,Woods, J. H., Domino, E. F., Jacob-son, A. E., Rafferty, M. F., Rice, K.C. and Lessor, R. A.: Effects of me-taphit, a proposed phencyclidine(PCP) receptor acylator, on catalepsyin pigeons, 648

Kondo, N., see Kodama, I., 507Konieczkowski, M. and Rudolph, S. A.:

Vasopressin-mediated protein phos-phorylation in intact toad urinary

bladder, 515Kost, S. B., see Londowski, J. M., 25

Kostyniak, P. J., see Mulder, K. M., 156

Kramer, R. A., Schuller, H. M., Smith, A.C. and Boyd, M. R: Effects of buth-ionine sulfoximine on the nephrotox-icity of 1-(2-chloroethyl)-3-(trans-

4-methylcyclohexyl)-1-nitrosourea

(MeCCNU), 498Kuhn, C. M. and Bartolome, M. B.: Effect

of chronic methadone administrationon neuroendocrine function in youngadult rats, 204

Kumar, R., see Londowski, J. M., 25

Kusunoki, M., Taniyama, K. and Tanaka,C.: Dopamine regulation of[3H]acetylcholine release fromguinea-pig stomach, 713

Labler, L., see Londowski, J. M., 25Lahita, R. G., see Aucoin, D. P., 13Lane, S. J. and Morgan, W. W.: Develop-

ment of tolerance to chronic barbital

treatment in the cerebellar cyclic

guanosine monophosphate systemand its response to subsequent bar-bital abstinence, 569

Lang, I. M., see Sarna, S. K., 814Langberg, H., Hartmann, A. and Kiil, F.:

Inhibitory effect of acetazolamide onrenal tubular reabsorption of

NaHCO3 and NaC1 in dogs variesinversely with plasma pH, 747

Lanthanum, surface membrane bound cal-cium, displacement, skeletal muscle(frogs), 233

Lead6-aminolevulinic acid dehydratase inhi-

bition, reversal, renal lead-bindingprotein (rats), 365

crop dysfunction induced by (pigeons),607

relaxation induced by, crop smooth mus-dc (pigeons), 616

Leander, J. D., Zerbe, R. L and Hart, J. C.:Diuresis and suppression of vasopres-

sin by kappa opioids: Comparisonwith mu and delta opioids and cloni-dine, 463

Le Bigot, J.-F., see Dumont, M., 239Lee, E. H. Y. and Mandell, A. J.: Relation-

ships between drug-induced changesin tetrahydrobiopterin and biogenicamine concentrations in rat brain,141

Lesch-Nyhan disease, dopamine receptors,functional supersensitivity (rats),

447Lessor, R A., see Koek, W., 648Leukotriene

C4 and D4, beta adrenergic responsivenessand, coronary artery (cows), 555

receptors, see Receptor

release pattern, lung parenchyma, 217Levy, G., see Hisaoka, M., 180Levy, G., see Ramzan, I. M., 624

Lewis, M. A., see Mong, S., 316Lidocaine, disposition and toxicity, opioid

effects (mice), 391Light reflex, pupillary, morphine effects

(cats), 603

Lindup, W. E., see Rosenbaum, S. E., 485Lipoxygenase, beta adrenergic responsive-

ness and, arachidonic acid metaboliteeffects on, coronary artery (cows),555

LiverN-acetylation, genetic differences (ham-

star), 358antipyrine metabolism, hypoxia and preg-

nancy effects on (rats), 584blood flow, see Blood flowdihydroergotamine uptake, troleandomy-

cm effects (rats), 239harmol conjugation, transit time and flow

direction alteration, effects on (rats),691

injury, carbon tetrachioride-induced, re-duced propranolol clearance (rats),470

necrosis, acetaminophen-induced, cimet-idine and N-acetylcysteine effects(rats), 550

oxidative metabolism, immunosuppres-

sive activities of 6-thiopurines(mice), 670

prazosin and antipyrine elimination, al-bumin and alpha-i acid glycoproteineffects (rats), 636

Lokhandwala, M. F., Watkins, H. 0., Se-bouni, M. H. and Alkadhi, K. A.:Pharmacological analysis of the ac-tions ofSKF 82526 on cardiovasculardopamine receptors, 337

Londowski, J. M., Kost, S. B., Gross, M.,Labler, L., Meier, W. and Kumar, R.:

1985 Index 843

Biologic activity of 3$-D-glucopyran-osides of vitamin D compounds, 25

Longhurst, P. A., see Goto, K., 280Lorazepam, clearance, probenecid impair-

meat of, 345Lucantom, D., see Massotti, M., 274Lucchesi, B. R., see Lynch, J. J., 72

Lucchesi, K. J., see Weselcouch, E. 0., 19Luneau, C. J., see Weselcouch, E. 0., 19Lung

compliance, in vivo measurements (dogs),491

metabolism, angiotensin converting en-zyme inhibition (rabbits), 372

nonadrenergic noncholinergic inhibitorysystem, 590

parenchyma, leukotriene release patterns,217

smooth muscle contraction, leukotrienereceptors and (guinea pigs), 316

Lurie, K. G., Tsujimoto, G. and Hoffman,B. B.: Desensitization of a�pha-1 ad-renergic receptor-mediated vascularsmooth muscle contraction, 147

Luster, M. I., see Tucker, A. N., 57

Luthin, G. R. and Wolfe, B. B.: Characteri-zation of [3Hjpirenzepine binding to

muscarinic cholinergic receptors sol-ubiized from rat brain, 37

LY150720, antinociceptive effects (mon-keys), 299

LY-171555, D-2 agonist, locomotor activityand (rats), 447

Lynch, J. J., Montgomery, D. G., Ventura,A. and Lucchesi, B. R.: Antiar-rhythmic and electrophysiologic ef-fects of bepridil in chronically in-farcted conscious dogs, 72

Lysergic acid diethylamide, discriminativestimulus properties (monkeys), 244

Macdonald, R. L., see Werz, M. A., 49MacLeod, K. M., see Broadley, K. J., 222

Majewski, H., see Ensinger, H., 681

Maldonado, A. L., see Speeg, K. V., Jr., 550Mandell, A. J., see Lee, E. H. Y., 141Maniwa, T., see Morita, T., 728Marijuana, binding sites, brain (rats), 784Marks, G. S., see Bennett, B. M., 228Marrazzi, M. A., McRae, W. and Brown, J.

A.: Thioglucose interactions with a“gold thioglucose-lesioned glucostat,”804

Massotti, M., Lucantoni, D., Caporali, M.G., Mele, L. and Gatta, F.: Supraspi-nal convulsions induced by inversebenzodiazepine agonists in rabbits,274

Matthews, W. D., see Jim, K. F., 161Mayersohn, M., see Woodworth, J. R., 654

McAllister, C. B., see Wedlund, P. J., 662

McCall, R. B., see Humphrey, S. J., 288McGiff, J. C., see Quilley, J., 211McNeil, J. H., see Broadley, K. J., 222McRae, W., see Marrazzi, M. A., 804

MDL 17,043, positive inotropic effect, yen-tricular muscle (dogs), 267

Meier, W., see Londowski, J. M., 25Meijer, D. K. F., see van der Sluijs, P., 703Melatonin receptors, see ReceptorMele, L., see Massotti, M., 274Membrane, depolarization, Goniopora tox-

ins and, axons (crayfish), 307Memory, triazolam us. pentobarbital effects,

120

Mendelsohn, L. G., Johnson, B. G., Scott,

W. L. and Frederickson, R C. A.:Thiorphan and analogs: Lack of cor-relation between potency to inhibit

“enkephalinase A” in vitro and an-algesic potency in vivo, 386

Mephenytoin, pharmacokinetics, pheno-

typic differences, normal subjects,662

Metal, urinary excretion, L-(aS,5S)-a-

amino-3-chloro-4,5-dihydro-5-isoxa-

zoleacetic acid effects (mice), 156Metaphit, phencyclidine receptor acylator,

effects on catalepsy (pigeons), 648Met-enkephalin, see Methionine enkepha-

haMethadone, chronic administration, neu-

roendocrine function and (rats), 204

Methanesulfonyl fluoride, edrophonium,physostigmine and, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539

Methionine enkephalininfusion into substantia nigra, maximal

electroshock seizure protection(rats), 45

intravenous, ventilatory response (dogs),677

motility stimulated by, cycbooxygenase in-hibitor effects, colon (rats), 742

renal nerve activity, suppression by (rab-bits), 534

Methoxamine, pressor response (dogs), 7280-Methylation, isoproterenol, aorta (rab-

bits), 184

Methylmercury, urinary excretion, L-(aS,

5S)-a-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid effects (mice),156

Methylphenidate, tetrahydrobiopterin and

biogenic amine concentrations,changes induced by, brain (rats), 141

Metoproloh, aspirin antihypertensive effect,

inhibition by (rats), 166

Meyer, W., see Bruckner, R., 766Mezzetti, M., see Sautebin, L., 217Microparticles, polyacryl starch, trapped

protein, immune response (mice), 255Microspheres, biodegradable, trapped pro-

tein, immune response (mice), 255Migrating myoelectric complex, biphasic re-

sponse to morphine, intestine (dogs),814

Miller, D. B., see O’Callaghan, J. P., 522Minneman, K. P., see Nasseri, A., 350Mitchell, M. C., see Speeg, K. V., Jr., 550Miura, A., see Muramatsu, I., 307Miyasato, K., see Henningfield, J. E., 1Moalli, R., Howell, R. E. and Gilhis, C. N.:

Kinetics of captopril- and enalapril-induced inhibition of pulmonary an-giotensin converting enzyme in vivo,372

Mohinoff, P. B., see Hedberg, A, 561Mong, S., Wu, H.-L., Scott, M. 0., Lewis,

M. A., Clark, M. A., Weichman, B.M., Kinzig, C. M.,Gleason, J. G. andCrooke, S. T.: Molecular heteroge-neity of leukotriene receptors: Cor-relation of smooth muscle contrac-tion and radioligand binding inguinea-pig lung, 316

Monoamine, regulation, drug effects, brain(rats), 141

Monomorphine, N-acetylation, genetic dif-ferences, liver (hamster), 358

Montgomery, D. G., see Lynch, J. J., 72

Morgan, W. W., see Lane, S. J., 569Morita, T., Maniwa, T., Satoh, K. and

Taira, N.: Undifferentiated effects ofcalcium antagonists on pressor re-sponses to selective a�pha-1 and a!-

pha-2 adrenoceptor agonists in anes-thetized, spinal dogs, 728

Morita, T., see Endoh, M., 267Morphine

biphasic response to, intestinal migratingmyoelectric complex (dogs), 814

electric shock titration and (monkeys),299

enantiomers, natural and unnatural(rats), 761

infusion into substantia nigra, maximalelectroshock seizure protection

(rats), 45opiate agonist-antagonist interactions,

drug discrimination (pigeons), 81pupillary effects (cats), 603

tolerance, escape titration and (monkeys),94

Mueller, R. A., see Breese, G. R., 447Mueller, R. A., see Duncan, G. E., 402

Mulder, G. J., see Dawson, J. R, 691Mulder, K. M. and Kostyniak, P. J.: Effect

of L-(aS,5S)-a-amino-3-chboro-4,5-dihydro-5-isoxazoleacetic acid on un-nary excretion of methylmercury inthe mouse, 156

Munamatsu, I., Fujiwara, M., Miura, A. and

Narahashi, T.: Effects of Gonioporatoxin on crayfish giant axons, 307

Murray, L., see Allen, T. M., 250Musacchio, J. M., see Bahouth, S. W., 326

Muscle, skeletaldigitalis receptors, [3H)ouabain distribu-

tion (guinea pigs), 720surface membrane bound calcium, dis-

placement (frogs), 233Muscle, smooth

contraction5-hydnoxytryptamine receptor-medi-

ated, aorta (rats), 443leukotriene receptors and, lung (guinea

pigs), 316dysfunction, lead-induced, crop (pigeons),

607postjunctional supersensitivity, reser-

pine-induced, alpha adnenergic recep-tors and (rats), 350

relaxation, lead-induced, crop (pigeons),616

vascularalpha-i receptor-mediated contraction,

desensitization (rabbits), 147calcium channels, bepnidil hydnochlo-

ride effects, aorta (rabbits), 63relaxation, W-7 anticalmodulin prop-

erties (rats, rabbits), 476ventricular, electrophysiobogy, dimethyl-

propranolol effects (guinea pigs), 507

Mydniasis, morphine-induced, pupillarylight reflex and fluctuation inhibition(cats), 603

Myocardium

Ca� and K� channels, blocking (frogs),134

ischemia and infarction, bepridil effects

(dogs), 72

844 Index Vol. 234

solutes, transcapillary transport (rabbits),19

Myosin, phosphorylation, perhexilene andcinnarizine effects, vascular and car-diac contractile protein (cows, dogs),629

Nakaki, T., Roth, B. L., Chuang, D.-M. andCosta, E.: Phasic and tonic compo-nent.s in 5-HT2 receptor-mediated rat

aorta contraction: Participation ofCa� channels and phospholipase C,442

Nakane, M., see Ogletree, M. L., 435Nakatsu, K., see Bennett, B. M., 228

Naloxonebiphasic response to, intestinal migrating

myoelectric complex (dogs), 814methionine enkephalin and, renal nerve

activity (rabbits), 534opiate infusion into substantia nigra and,

maximal electroshock seizure protec-tion (rats), 45

Naloxone methobromide, methionine en-kephalin and, renal nerve activity(rabbits), 534

Naltrexone, opiate agonist-antagonist inter-actions, drug discrimination (pi-geons), 81

l-Nantradol, tolerance, escape titration and

(monkeys), 94Napier, T. C., see Breese, G. R., 447Narahashi, T., see Muramatsu, I., 307Nasseri, A., Barakeh, J. F., Abel, P. W. and

Minneman, K. P.: Reserpine-inducedpostjunctional supersensitivity in rat

vas deferens and caudal artery with-out changes in alpha adnenergic re-ceptors, 350

Neostigmine, nonadnenergic inhibitory sys-tam, lung (cats), 590

Nephrectomy, gentamicin excretion and(dogs), 90

Nephrotoxicity

aminoglycoside excretion, nephrectomyand (dogs), 90

antibiotic, augmentation by endotoxemia(rabbits), 425

1-(2-chloroethyl)-3-(trans-4-methylcy-cbohexyl)-1-nitrosourea, buthioninesulfoximime effects on (rats), 498

Nervous systemcentral

bihirubin neurotoxicity and cerebellarproteins (rats), 522

SKF 82526 and, cardiovascular dopa-mine receptors (dogs), 337

sympathetichyperinnervation, spontaneous hyper-

tension and, caudal artery (rats), 792

inhibitory response, y-aminobutyricacid mediation (cats), 288

renal nerve activity, suppression by me-thionine enkephahin (rabbits), 534

Neural adaptation, antidepressants andforced swim, beta adnenergic receptordown-regulation (rats), 402

Neuromuscular junction, cholinergic, teta-

nus toxin binding (mice), 100Neuron, giant, slow outward current, bar-

biturate-induced alterations (mol-

lusks), 821Neuropeptide Y, noradnenaline-eyoked va-

soconstriction and (rabbits), 735

Neunotoxicity, bihirubin, cerebellar proteins

and (rats), 522Nicotine

behavioral effects (dogs, monkeys), 106

intravenous and inhaled, abuse liabilityand pharmacodynamic characteris-tics, 1

renal clearance, nicotine intake and, 153

Nielsen, E. B.: Discriminative stimulusproperties of lysergic acid diethyl-amide in the monkey, 244

Nifedipine

aorta contraction and (rats), 443beta receptors and, heart, 561calcium channels, effects on, vascular

smooth muscle of aorta (rabbits), 63vasodepressor effects (dogs), 728

Nimodipine, a�pha adnenergic activation, in-hibition by, saphenous vein (dogs),598

Nitrate, organic, biotransformation byerythrocytes, 228

2-Nitro-4-carboxyphenyl-N,N-diphenylcar-

bamate, aorta contraction and (rats),443

Nitroglycerin, capillary permeability and,myocardium (rabbits), 19

Nobis, T.-M., see Bruckner, R., 766Nomifensine, forced swim and, beta adne-

nergic receptor down-regulation

(rats), 402Noradrenaline, see Norepinephnine

Norcocaine, behavioral effects (dogs, mon-keys), 106

Norepinephrinealpha adnenoceptors and, intermediate

auricular artery (dogs), 698cyclic nucleotide generating system, imi-

pramine and adrenocorticotropin ef-fects on, brain (rats), 409

hyperinnervation, spontaneous hyperten-sion and, caudal artery (rats), 792

nimodipine and, saphenous vein (dogs),598

release, blood pressure, dopamine andbromocriptine effects (rabbits), 681

reserpine-induced postjunctional super-sensitivity and, van deferens and cau-dal artery (rats), 350

vasoconstriction evoked by, potentiationby neuropeptide Y (rabbits), 735

N#{248}rgaard, A., see Kjeldsen, K., 720Nornicotine, behavioral effects (dogs, mon-

keys), 106Northrup, N., see Tuttle, R. S., 166

Nucheotide, guanine, [3H]substance P bind-ing, submaxillary gland (rats), 326

Nyc, J. S., Seltzman, H. H., Pitt, C. G. andSnyder, S. H.: High-affinity canna-binoid binding sites in brain mem-branes labeled with [3H]-5’-trimeth-ylammoniuin �8-tetrahydnocannabi-nol, 784

O’Brien, M. S., Salamone, L. F. and Gibson,T. P.: Effect of spironolactone on therenal clearance of digoxin in dogs,190

O’Callaghan, J. P. and Miller, D. B.: Cere-bellar hypoplasia in the Gunn rat isassociated with quantitative changesin neurotypic and ghiotypic proteins,522

Oculomucocutaneous syndrome, practobol-induced (hamsters), 476

O’Donnell, J. M. and Fraser, A.: Effects ofclenbuterol and antidepressant drugs

on beta adrenergic receptor/N-pro-tein coupling in the cerebral cortexof the rat, 30

Ogletree, M. L., Harris, D. N., Greenberg,R, Haslanger, M. F. and Nakane, M.:Pharmacological actions of SQ29,548, a novel selective thrombox-ane antagonist, 435

#{248}ie,S. and Fiori, F.: Effects of albumin andalpha-i acid glycoprotein on ehimi-nation of prazosin and antipynine inthe isolated perfused rat liver, 636

Opiate

biphasic response to, intestinal migratingmyoelectric complex (dogs), 814

infusion into substantia nigra, maximal

electroshock seizure protection

(rats), 45methadone, chronic administration, neu-

roendocrine function and (rats), 204

Opioidkappa, diuresis and vasopressin suppres-

sion (rats), 463lidocaine disposition and toxicity, effects

on (mice), 391pupillary light reflex, effects on (cats), 603

surface membrane bound calcium, dis-placement, skeletal muscle (frogs),233

Opioid peptidecalcium-dependent action potential du-

ration, dorsal root ganglion neuron(mice), 49

methionine enkephalin, renal nerve activ-ity suppression (rabbits), 534

Orton, T. C., see Rosenbaum, S. E., 485Ouabain, 3H-labehed, binding, digitalis re-

ceptors and, skeletal muscle (guineapigs), 720

Owens, S. M., see Woodworth, J. R., 654Oxidative metabolism, hepatic, influence on

6-thiopunine metabolites (mice), 670

Pang, K. S., see Dawson, J. R., 691Parenchyma

contractility, mediators of anaphylaxisand (dogs), 491

lung, leukotriene release patterns, 217

Pargyline, forced swim and, beta adrenergic

receptor down-regulation (rats), 402Patel, S., see Tuttle, R. S., 166

Paul, I. A., see Duncan, G. E., 402Paul, R J., see Rubanyi, G. M., 555

Pentobarbital, triazolam vs., 120Pentylenetetrazol, convulsions and, serum,

brain and cerebrospinal fluid (rats),624

Peptideopioid, see Opioid peptideperoral, diabetes insipidus treatment, 754

Peptidoleukotriene, smooth muscle contrac-tion and, lung (guinea pigs), 316

Perhexilene, vascular and cardiac contract-ile protein function, effects on (cows,dogs), 629

Peterson, D. F., see Rhee, H. M., 534Peterson, M. E., see Aucoin, D. P., 13pH

blood-brain gradient, influence on pheno-barbital uptake, status epilepticus,830

electrolyte reabsorption and, acetazol-

1985 Index 845

amide effects, kidney tubules (dogs),747

urinary, nicotine intake and clearance,153

Phagocytic index, enzyme-albumin conju-gates, chronic administration effects

(mice), 250Pharmacokinetics, probenecid, glucuroni-

dation inhibition, 345Phencycidine

disposition kinetics (dogs), 654receptor acylator, catalepsy, effects on

(pigeons), 648tolerance and physical dependence (rats),

415

Phenidone, beta adnenergic responsiveness,arachidonic acid metabolite effectson, coronary artery (cows), 555

Phenobarbitalmorphine and, comparative metabolism

(rats), 761uptake, blood-brain pH gradient influence

on, status epilepticus (rats), 830

uremia and (rats), 180Phenotype, oxidative, mephenytoin, normal

subjects, 662

Phenoxybenzamine, nimodipine and, saphe-nous vein (dogs), 598

Phenylephrine, a�pha adrenoceptors and,intermediate auricular artery (dogs),698

Phenylethylhydantoin, pharmacokinetics,phenotypic differences, normal sub-jects, 662

Phosphoinositide, hydrolysis, serotonin-stimulated (rats), 195

Phosphoinositol, turnover, a!pha-1 receptor

stimulation of, desensitization (rab-bits), 147

Phosphohipase C, calcium ion channels and,aorta contraction mechanism (rats),

443

Phosphohipids, serotonin effects (rats), 195

Phosphorylationmyosin, perhexilene and cinnarizine ef-

fects, vascular and cardiac contractileprotein (cows, dogs), 629

protein, vasopressin-mediated, urinary

bladder (toads), 515Physostigmine, edrophonium and methane-

sulfonyl fluoride, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539

Picenadol, antinociceptive effects (mon-keys), 299

Pickworth, W. B. and Sharpe, L. G.: Mor-phine-induced mydniasis and inhibi-tion ofpupillary light reflex and fluc-tuations in the cat, 603

Picrotoxin, vasopressin release stimulatedby (rats), 378

Pinto, P. B., see Silver, P. J., 629Pirenzepine, radiolabeled, binding to mus-

caninic chohinergic receptors, brain(rats), 37

Pitt, C. G., see Nye, J. S., 37Platelet, aggregation inhibition, SQ 29,548,

435Polyacryl starch, microparticles, protein

trapped in, immune response (mice),255

Pond, S. M., see Waschek, J. A., 431

Potassium, currents, blocking, calciumchannel antagonists (frogs), 134

Poznansky, M. J., see Allen, T. M., 250

Practolol, metabohites, disposition (ham-stern), 485

Prada, J. A., see Risner, M. E., 113

Prazosinalpha adrenoceptors and, intermediate

auricular artery (dogs), 698elimination, albumin and a4,ha-1 acid

glycoprotein effects, liver (rats), 636nimodipine and, saphenous vein (dogs),

598urapidil and, reflex tachycandia suppres-

sion (dogs), 456Pregnancy, hypoxia and, antipynine metab-

olism, liver (rats), 584Probenecid, glucuronidation inhibition by,

345

Propranololbeta receptors and, heart, 561clearance, reduced, carbon tetrachloride

and, liver (rats), 470Propylthiouracil, toxicity (cats), 13Prostacychin

beta adrenergic responsiveness, effects on,

coronary artery (cows), 555vascular, diabetes melhitus (rats), 211

Prostaglandin

colonic motility and (rats), 742SQ 29,548 effects (humans, guinea pigs,

rats), 435urinary excretion, diabetes melhitus and

(rats), 211Prostaglandin E�

beta adrenergic responsiveness, effects on,coronary artery (cows), 555

prostaglandin E� and, renal, metoprololand aspirin antihypertensive effects(rats), 166

renin release and, arachidonic acid infu-sion (dogs), 261

Prostaglandin E�, prostaglandin E� and,renal, metoprolol and aspirin anti-hypertensive effects (rats), 166

Prostanoids, prostaglandin D2 and Ff4,, air-way reactivity to (dogs), 491

Proteinalpha-i acid and asialo c4pha-1 acid gly-

coprotein, cation binding, 703alpha-i acid glycoprotein, prazosin and

antipynine elimination, liver (rats),

636contractile, vascular and cardiac, calcium

antagonist effects on (cows, dogs),629

lead-binding, renal, #{246}-aminolevulinic aciddehydratase inhibition reversal(rats), 365

myelin basic, bihirubin neurotoxicity and(rats), 522

neurotypic and gliotypic, cerebehlar hy-poplasia and (rats), 522

phosphorylation, vasopressin-mediated,urinary bladder (toads), 515

Psychoactive drugs, marijuana, bindingsites, brain (rats), 784

Psychomotor performance, triazolam vs.pentobarbital effects, 120

Pung, 0., see Tucker, A. N., 57

Pupil, light reflex and fluctuation, inhibi-tion, morphine-induced mydniasisand (cats), 603

Purkinje cells, biirubin neurotoxicity, cer-ebellum (rats), 522

Purkinje fibers, caffeine-induced calciumoverload, reversal (dogs), 172

Quilley, J. and McGiff, J. C.: Arachidonicacid metabolism and urinary excre-tion ofprostaglandins and thrombox-ane in rats with experimental diabe-tes melhitus, 211

Quimby, F. W., see Aucoin, D. P., 13

Radioligandbinding

cannabinoid, brain (rats), 784smooth muscle contraction and, leuko-

triene receptors, lung (guinea pigs),

316Rafferty, M. F., see Koek, W., 648Ramzan, I. M. and Levy, G.: Kinetics of

drug action in disease states. XIV.Effect of infusion rate on pentylene-tetrazol concentrations in serum,brain and cerebrospinal fluid of ratsat onset of convulsions, 624

Rane, A., Gawronska-Szklarz, B. and Svens-son, J.-O.: Natural (-)- and unnatu-ral (+)-enantiomers of morphine:Comparative metabolism and effectof morphine and phenobarbital treat-

ment, 761Ratz, P. H., see Flaim, S. F., 63Ratz, P. H. and Flaim, S. F.: Acetylchohine-

and 5-hydroxytryptamine-stimulatedcontraction and calcium uptake inbovine coronary arteries: Evidencefor two populations of receptor-op-erated calcium channels, 641

Rauwolscine, nimodipine and, saphenousvein (dogs), 598

Receptor

alpha adrenergic, reserpine and, vas def-erens and caudal artery (rats), 350

alpha-i adnenergic, smooth muscle con-

traction, desensitization (rabbits),147

a4pha and beta adrenergic, cyclic nucleo-tide generating system, imipramineand adnenocorticotropin effects on,brain (rats), 409

beta adrenergiccoupling with N-protein, clenbuterol

and antidepressant drug effects(rats), 30

down-regulation, antidepressants andforced swim (rats), 402

beta-i and beta-2 adrenergic, coexistence,heart, 561

calcium channel operation, coronary ar-

tery contraction (cows), 641

cannabinoid binding sites, brain (rats),784

digitalis, [3H]ouabain binding and, skele-tel muscle (guinea pigs), 720

dopaminecardiovascular, SKF 82526 and (dogs),

337functional supersensitivity (rats), 447pre- and postjunctional, blood pressure

effects (rabbits), 681

histamine, smooth muscle contractionmediated by, desensitization (rab-bits), 147

leukotriene, molecular heterogeneity,

lung (guinea pigs), 316melatonin, retinal (rabbits, chickens), 395muscaninic cholinergic, [3H]pirenzepine

binding to, brain (rats), 37opiate, trimebutine effects on colon elec-

tromyogram (cats, rabbits), 708

846 Index Vol. 234

opioid, kappa, calcium conductance(mice), 49

phencyclidine, acylator, effects on cats-

lepsy (pigeons), 648reserve, nimodipine and, saphenous vein

(dogs), 598serotonin

aorta contraction, phasic and toniccomponents (rats), 443

5-HT1 and 5-HT2, behavior and (mon-keys), 106

substance P, binding, submaxillary gland(rats), 326

Receptor acylator, phencychidine, catalepsyand (pigeons), 648

Receptor-channel complex, end-plate ace-tylchohine, edrophonium, physostig-mine and methanesulfonyl fluorideinteractions with (snakes), 539

Red blood cell, see ErythrocyteReidenberg, M. M., see Aucoin, D. P., 13Renal artery, constriction, prostaghandin E�

and ream release, arachidonic acidinfusion (dogs), 261

Renal nerve, activity suppression, methio-nine enkephalin (rabbits), 534

Renin, release, prostaglandin E� and, arach-idonic acid infusion (dogs), 261

Reserpine, postjunctional supersensitivityinduced by, vas deferens and caudalartery (rats), 350

Responsiveness, beta adnenergic, arachi-

donic acid metabohite effects on, cor-onary artery (cows), 555

Reticuloendothelial system, enzyme-albu-mm conjugates, chronic administra-tion effects (mice), 250

Retina, melatonin receptor (rabbits, chick-ens), 395

Reyntjens, A. J., see Schuurkes, J. A. J., 775

Rhee, H. M., Eulie, P. J. and Peterson, D.F.: Suppression of renal nerve activ-ity by methionine enkephahin inanesthetized rabbits, 534

Rice, J. C., see Evanich, M. J., 677Rice, K. C., see Koek, W., 648Rice, P. J., see Goto, K., 280Righting reflex, loss, phenobarbital and ure-

mia (rats), 180

Rimele, T. J., see Cooke, J. P., 598Risner, M. E., Goldberg, S. R., Prada, J. A.

and Cone, E. J.: Effects of nicotine,cocaine and some of their metaboliteson schedule-controlled responding bybeagle dogs and squirrel monkeys,113

Riviere, J. E., Bowman, K. F. and Rogers,R. A.: Decreased fractional renal ex-cretion of gentamicin in subtotal

nephrectomized dogs, 90Roache, J. D. and Griffiths, R. R.: Compar-

ison of triazolam and pentobarbital:Performance impairment, subjectiveeffects and abuse liability, 120

Rodgers, R. L., see Broadley, K. J., 222

Rogers, R A., see Riviere, J. E., 90

Rosenbaum, S. E., Lindup, W. E. and Orton,T. C.: Practolol and its metabohites:

Tissue localization and retention inthe hamster, 485

Rotarod, phencycidine tolerance and (rats),415

Roth, B. L., see Nakaki, T., 442

Rubanyi, G. M. and Paul, R. J.: Modulationof beta adnenergic responsiveness by

arachidonic acid metabolites in iso-lated bovine coronary arteries, 555

Rubin, G. M., see Waschek, J. A., 431Rudolph, S. A., see Konieczkowski, M., 515

Sabouni, M. H., see Lokhandwala, M. F.,337

Salamone, L. F., see O’Brien, M. S., 190Salicylamide, dose-dependent sulfoconjuga-

tion (dogs), 431

Sander, G. E., see Evanich, M. J., 677Sanders-Bush, E., see Conn, P. J., 195Saphenous vein

a4pha adrenergic receptors, nimodipine ef-fects (dogs), 598

contractions, a�pha-2 adnenoceptors and,calcium role (dogs), 161

Sarna, S. K. and Lang, I. M.: Dose- andtime-dependent biphasic response to

morphine on intestinal migratingmyoelectric complex, 814

Satoh, H. and Vassalle, M.: Reversal of cal-feine-induced calcium overload incardiac Purkinje fibers, 172

Satoh, K., see Morita, T., 728Satoh, M., see Iwamoto, K., 470

Sautebin, L., Vigan#{244}, T., Grassi, E., Crivel-

lan, M. T., Galhi, G., Berti, F., Mez-zetti, M. and Folco, G.: Release ofheukotrienes, induced by the Ca�ionophore A23187, from human lungpanenchyma in vitro, 217

SCH-23390, D-1 antagonist, locomotor ac-tivity and (rats), 447

Scheurer, U., Drack, E. and Halter, F.: Cy-cbooxygenase inhibitors affect Met-

enkephalin- and acetylchohine-stim-ulated motility of the isolated rat co-ba, 742

Schmitz, W., see Bruckner, R., 766Scholz, H., see Bruckner, R., 766Schuller, H. M., see Kramer, R. A., 498Schuurkes, J. A. J., Van Nueten, J. M., Van

Daele, P. G. H., Reyntjens, A. J. andJanssen, P. A. J.: Motor-stimulatingproperties of cisapride on isolatedgastrointestinal preparations of the

guinea pig, 775Scott, M. 0., see Mong, S., 316Scott, W. L., see Mendelsohn, L. G., 386Seizure, maximal electroshock, protection,

opiate infusion into substantia nigra

(rats), 45Sejersted, 0. M., see Vikse, A., 261Seltzman, H. H, see Nye, J. S., 37Serotonin

acetylchohine and, calcium channels acti-vated by, coronary artery (cows), 641

agonists and antagonists, lysergic acid di-ethylamide discriminative stimulusproperties (monkeys), 244

antagonists, behavioral effects (mon-keys), 106

binding sites, phosphoinositide hydrolysisand (rats), 195

receptors, see ReceptorSerum, pentylenetetrazol concentrations,

infusion rate effects on, convulsions(rats), 624

Shader, R. I., see Abernethy, D. R., 345Sharpe, L. G., see Pickworth, W. B., 603

Shebuski, R. J. and Zimmerman, B. G.: Sup-pression of reflex tachycardia by cen-tm! administration ofthe aLpha-i ad-

renoceptor antagonists unapidil and

prazosin in anesthetized dogs, 456Shetty, S. S. and Frank, G. B.: Displacement

of the surface membrane bound cal-cium of the skeletal muscle fibers ofthe frog Effects of lanthanum andopioids, 233

Shibata, S., see Kodama, I., 507Silver, P. J., Dachiw, J., Ambrose, J. M. and

Pinto, P. B.: Effects of the calciumantagonists perhexiline and cinnari-zine on vascular and cardiac con-tractile protein function, 629

Simon, R. P., Benowitz, N., Hedlund, R.and Copeland, J.: Influence of theblood-brain pH gradient on brain

phenobarbital uptake during statusepilepticus, 830

Simpson, L. L.: Pharmacological experi-meats on the binding and internali-zation of the 50,000 dalton carboxy-

terminus of tetanus toxin at the cho-linergic neuromuscular junction, 100

Sj#{246}holm, I., see Artursson, P., 255SKF-38393, D-i agonist, locomotor activity

and (rats), 447SKF 82526, cardiovascular dopainine recep-

tors and (dogs), 337Smith, A. C., see Kramer, R. A., 498

Smith, J. B.: Effects of single and repeateddaily injections of morphine, clom-dine and 1-nantradol on respondingof squirrel monkeys under escape ti-tration, 94

Snyder, S. H., see Nye, J. S., 37Sodium, conductance, dimethylpropranolol

effects, ventricular muscles (guineapigs), 507

Sodium channelfast, dimethylpropranohol effects, ventric-

ular muscles (guinea pigs), 507Gornopora toxin effects, axons (crayfish),

307Sonenberg, M., see Haspel, H. C., 575

Spain, J. W. and Klingman, G. I.: Continu-ous intravenous infusion of phency-cidine in unrestrained rats results inthe rapid induction of tolerance andphysical dependence, 415

Spannnhake, E. W., Kadowitz, P. J. andKleeberger, S. R.: Influence of media-tors of anaphylaxis on collateral yen-tilation and the lung periphery of thedog, 491

Speeg, K. V., Jr., Mitchell, M. C. and Mal-donado, A. L.: Additive protection ofcimetidine and N-acetylcysteinetreatment against acetaminophen-induced hepatic necrosis in the rat,550

Spinal cord, transection, vasopressin releasestimulation, �y-aminobutynic acid an-tagonista (rats), 378

Spironolactone, digoxin, renal clearance(dogs), 190

SQ 29,548, thromboxane antagonist (hu-mans, guinea pigs, rats), 435

St-587, nimodipine and, saphenous vein

(dogs), 598Starke, K., see Ensinger, H., 681Status epilepticus, phenobanbital uptake

during, blood-brain pH gradient in-fluence on (rats), 830

Stiliwell, R. N., see Dawson, J. R., 691Stitzel, R. E., see Cassis, L. A., 792

1985 Index 847

Stitzel, R. E., see Head, R. J., 184

Stomach, [3H�acetylcholine release, dope-mine regulation or (guinea pigs), 713

Strada, S. J., see Duman, R. S., 409

Street value, estimated, triazolam vs. pen-tobarbital, 120

Structure-activity relationships, melatoninderivatives (rabbits, chickens), 395

Stumpf, W. E., see Duncan, G. E., 402Submaxillary gland, [3Hjsubstance P, spa-

cific binding (rats), 326Substance P, [3H]-labeled, specific binding,

submaxillary gland (rats), 326Substantia nigra, opiate infusion into, max-

imal electroshock seizure protection(rats), 45

Sucrose, permeability-surface area prod-ucts, transcapillary transport, myo-cardium (rabbits), 19

Sulfate, depletion or administration, sulfo-conjugation (dogs), 431

Sulfoconjugation, dose-dependent, salicyl-amide (dogs), 431

Sulmazole, positive inotropic effect, ventric-ular muscle (dogs), 267

Sulpiride, [3Hjacetylcholine release, dopa-mine regulation of, stomach (guineapigs), 713

Supersensitivity, reserpine-induced. a�phaadrenergic receptors and, vas defer-ens and caudal artery (rats), 350

Svensson, J.-O., see Rane, A., 761Swigart, S. C., see Flaim, S. F., 63Sympathectomy, cardiac, sensitivity to ag-

onists and (rats, guinea pigs), 280Sympathetic nervous system, see Nervous

systemSynapsin I, phosphoprotein, bihirubin neu-

rotoxicity and, cerebellum (rats), 522Szarek, J. L., see Altiere, R. J., 590

Tachycardia

reflex, aZpha-1 adrenoceptor antagonist

effects (dogs), 456ventricular, bepridil effects (dogs), 72

Tachykinin receptors, see ReceptorTaira, N., see Endoh, M., 267Taira, N., see Morita, T., 728Tanaka, C., see Kusunoki, M., 713Taniyama, K., see Kusunoki, M., 713Taylor, D. A., see Goto, K., 280Tetanus toxin, binding, cholinergic neuro-

muscular junction (mice), 100

12-O-Tetradecanoylphorbol-13-acetate,aorta contraction and (rats), 443

Tetrahydrobiopterin, drug effects on, brain(rats), 141

Tetrahydrocannabinol, binding sites, brain(rats), 784

Tetrodotoxincaffeine-induced calcium overload and,

Purkinje fibers (dogs), 172Goniopora toxins and, axons (crayfish),

307Thioglucose, “gold thioglucose-lesioned glu-

costat” and, interactions (mice), 8046-Thiopurine, metabolites, immunosuppres-

sive, hepatic oxidative metabolisminfluence on (mice), 670

Thiorphan, analgesia and (rats), 386

Thromboxaneantagonist, SQ 29,548 (humans, guinea

pigs, rats), 435urinary excretion, diabetes melhitus and

(rats), 211

Thromboxane A2antagonist, SQ 29,548 (humans, guinea

pigs, rats), 435formation, lung, 217

Thromboxane synthetase, SQ 29,548 ef-fects, platelets (humans, guinea pigs,rats), 435

Tozer, T. N., see Waschek, J. A., 431Trachea

contraction inhibition, SQ 29,548 effects(guinea pigs), 435

neurally mediated nonadrenergic relaxa-

tion (cats), 590

Transmembrane potential, dimethylpro-pranolol effects, ventricular muscles(guinea pigs), 507

Triazolam, pentobarbital vs., 120Trimebutine, colon electromyogram, effects

on (cats, rabbits), 708Troleandomycin, dihydroergotamine up-

take, effects on, liver (rats), 239Tsujimoto, G., see Lurie, K. G., 147Tucker, A. N., Hong, L., Boorman, G. A.,

Pung, 0. and Luster, M. I.: Alterationof bone marrow cell cycle kinetics bydiphenylhydantoin: Relationship to

folate utilization and immune func-tion, 57

Tune, B. M. and Hsu, C.-Y.: Augmentationof antibiotic nephrotoxicity by endo-toxemia in the rabbit, 425

Tuttle, R. S., Banziger, V., Patel, S. andNorthrup, N.: Inhibition by metopro-

lol of the antihypertensive effect ofaspirin in young rats, 166

Tyramine, nimodipine and, saphenous vein(dogs), 598

UM-272, see DimethylpropranololUrapidil, prazosin and, reflex tachycardia

suppression (dogs), 456Uremia, dialyzable components, phenobar-

bital concentrations and, loss ofrighting reflex (rats), 180

Ureter, occlusion, prostaglandin E� andream release, anachidonic acid infu-sion (dogs), 261

Urination, vasopressin suppression, diuresisand, kappa opioids (rats), 463

Urinemethylmercury excretion, L-(aS,5S)-a-

amino-3-chloro-4,5-dihydro-5-isoxa-zoleacetic acid effects (mice), 156

pH, nicotine intake and clearance, 153prostaglandin and thromboxane excre-

tion, diabetes mellitus (rats), 211

Van Daele, P. G. H., see Schuurkes, J. A. J.,775

van der Sluijs, P. and Meijer, D. K. F.:Binding of drugs with a quaternaryammonium group to a�pha-i acid gly-coprotein and asialo a!pha-1 acid gly-coprotein, 703

Vanhoutte, P. M., see Cooke, J. P., 598Van Nueten, J. M., see Schuurkes, J. A. J.,

775Vardax, vascular and cardiac contractile

protein function, effects on (cows,dogs), 629

Vas deferens, postjunctional supersensitiv-ity, reserpine-induced, a�pha adrener-gic receptors and (rats), 350

Vasoconstriction, noradrenaline-evoked,

potentiation by neuropeptide Y (rab-bits), 735

Vasodilation

autoregulatory, prostaglandin E� andrenin release, arachidonic acid infu-sion (dogs), 261

coronary, transcapillany solute transport,myocardium (rabbits), 19

Vasopressin

protein phosphorylation mediated by, un-nary bladder (toads), 515

release, stimulation by y-aminobutynicacid antagonists (rats), 378

suppression, diuresis and, kappa opioids(rats), 463

Vassalle, M., see Satoh, H., 172Velocity, maximal initial, dimethylpropran-

olol effects, ventricular muscles(guinea pigs), 507

Ventilationcollateral, anaphylaxis mediators and,

lung periphery (dogs), 491methionine enkephalin effects (dogs), 677

Ventura, A., see Lynch, J. J., 72Verapamil

calcium channels, effects on, vascularsmooth muscle of aorta (rabbits), 63

diltiazem and, coronary artery contrac-tion (cows), 641

Vigan#{244},T., see Sautebin, L., 217

Vikse, A., Sejersted, 0. M. and Kiil, F.:Autoregulatory vasodilation en-hances renal prostaglandin E� andassociated ream release during ar-achidonic acid infusion in dogs, 261

Vilhardt, see Hammer, M., 754Vitamin D, 3�-D-glucopynanosides, biologic

activity (rats), 25Voltage clamp

cardiac, myocardial Ca� and K� channelblocking (frogs), 134

Goniopora toxins and, axons (crayfish),307

slow outward current, barbiturate-in-duced alterations (mollusks), 821

Vore, M., see Brouwer, K. L. R., 584

W-7anticalmodulin properties, artery (rats,

rabbits), 476vascular and cardiac contractile protein

function, effects on (cows, dogs), 629Wahlestedt, C., Edvinsson, L., Ekblad, E.

and H#{226}kanson,R: Neuropeptide Ypotentiates noradrenaline-evokedvasoconstriction: Mode of action, 735

Waschek, J. A., Fielding, R. M., Pond, S.M., Rubin, G. M., Effeney, D. J. andTozer, T. N.: Dose-dependent sulfo-conjugation of sahicylamide in dogs:Effect of sulfate depletion or admin-istration, 431

Watanabe, J., see Iwamoto, K., 470Watkins, H. 0., see Lokhandwala, M. F.,

337Weber, W. see Hein, D. W., 358Wedlund, P. J., Aslanian, W. A., Jacqz, E.,

McAllister, C. B., Branch, R. A. andWilkinson, G. R.: Phenotypic differ-ences in mephenytoin pharmacoki-netics in normal subjects, 662

Weichman, B. M., see Mong, S., 316Weitering, J. G., see Dawson, J. R., 691Werz, M. A. and Macdonald, R. L.: Dynor-

phin and neoendorphin peptides de-

848 Index

crease dorsal root ganglion neuroncalcium-dependent action potentialduration, 49

Weselcouch, E. 0., Lucchesi, K. J., Luneau,C. J. and Gossehin, R. E.: Transcap-illary transport ofsolutes in the myo-cardium: Effects of nitroglycerin, iso-proterenol and histamine on perme-ability-surface area products of insu-ha and sucrose, 19

Wible, J. H., Jr., Zerbe, R. L. and DiMicco,J. A.: Stimulation of vasopressinrelease by ‘y-aminobutynic acid an-tagonists in spinal cord transectedrats, 378

Wilkinson, G. R., see Wedlund, P. J., 662

Wilson, W. A., see Huguenard, J. R., 821Withdrawal abstinence syndrome, phency-

cidine, rotarod performance and(rats), 415

Wolfe, B. B., see Luthin, G. R., 37Woods, J. H., see France, C. P., 81Woods, J. H., see Koek, W., 648Woodworth, J. R., Owens, S. M. and May-

ersohn, M.: Phencyclidine (PCP) dis-position kinetics in dogs as a functionof dose and route of administration,654

Wu, H.-L., see Mong, S., 316

Vol. 234

Xylazine

a’pha adrenoceptors and, intermediateaunicular artery (dogs), 698

pressor response (dogs), 728

Yamada, K., see Kodama, I., 507Yanagisawa, T., see Endoh, M., 267Yohimbine, alpha adrenoceptors and, inter-

mediate auricular artery (dogs), 698

Zerbe, R.L., see Leander, J. D., 463Zerbe, R. L., see Wible, J. H., Jr., 378Zimmerman, B. G., see Shebuski, R. J., 456