527

INDEX

Volume 208, January-March 1979

Abstinence syndrome, morphine,

rats, effects of antipsychoticand antianxiety drugs, 63

Acara, M., see Koschier, F. J., 287

Activator, calcium-dependent, of

cyclic nucleotide phosphodi-esterase, selective binding ofantipsychotics and other psy-choactive agents to, 454

Adenosine triphosphatase,catecholamine-sensitive, in

mouse brain, effects of acuteand continuous morphinetreatment, 80

Adenylate cyclase, ganglionic,stimulation by catechol-

amines, 31

Adler, C. H., see Klemfuss, H., 91

Adler, M. W.see Klemfuss, H., 91

see Baldino, F., Jr., 63

Adrenal gland

phenylethanolamine N-meth-yltransferase, effects of

SK&F 28661,24steroids, indirectly modulating

morphine and fl-endorphin

effects, 176Adrenergic mechanisms, domi-

nance in mediating hypoten-sive drug-induced renin

release in conscious rat, 303Age, relationship to metabolism

and protein binding of di-

goxin in sheep, 263

Alkadhi, K., see Quenzer, L., 31

Alloxan, selectivity for fl-cells of

islets of Langerhans, effect ofpH, 184

Alphaprodine, intravenous, rela-

tive potency and duration of

action with respect to respi-ratory depression in man, 73

Alward, C. T., see Baiie, M. D.,298

y-Aminobutyric acid, neurons in

caudatus, pallidus and nigra,effects of opioids and dopa-mine agonists, 190

Aminopyrine N-demethylase, cy-tochrome P-450-dependent,in rat brain, comparison withhepatic aminopyrine N-de-

methylation, 271

d-Amphetamine, anorexic effect,tolerance to, effect of deple-tion of brain dopamine by 6-hydroxydopamine, 134

Analgesia, morphine-induced, dif-

ferential effects of leucineand methionine enkephalin,86

Anesthesia, effect on cardiovas-

cular and renal function in

newborn piglet, 298

Anorexic effect, of d-ampheta-mine and fenfluramine in

rats, tolerance to, effect of de-

pletion of brain dopamine by

6-hydroxydopamine, 134Antianxiety drugs, effects on mor-

phine abstinence syndromein rats, 63

Anticholinergic actions, stereo-

specific, of enantiomers of

CTC, cyproheptadine deriv-ative, 460

Anticonvulsant drugs, protein

binding in serum of dog and

man, 429

Anticonvulsant effects

of benzhydryl piperazines on

maximal electroshock sei-

zures in rats, 480of ropazine in rat, 236

Antidopaminergic actions, stereo-

specific, of enantiomers of

CTC, cyproheptadine deny-ative, 460

Antihypertensive effects, of MK-

447, 148

Antihypertensive treatment, ef-fects on systolic blood pres-

sure and renin experimental

hypertension in rats, 310

Antimeperidine antibodies, speci-ficity and reactivity withopioid peptides, 498

Antimorphine antibodies, speci-

ficity and reactivity with

opioid peptides, 498

Antinociception, mediated by

spinal serotonin terminal sys-tem, 446

Antipsychotic drugs

effects on morphine absti-

nence syndrome in rats, 63selective binding to calcium-de-

pendent activator of cyclic

nucleotide phosphodiester-ase, 454

Antitubulin agent, nocodazole, ac-tion on tubulin assembly, ax-onal ultrastructure and fast

axonal transport, 411

Antitumor activity, of BCNU,CCNU and PCNU, effect ofphenobarbital pretreatment,

Aorta, strips, isolated, rabbit, con-

tractile response to unsatu-rated fatty acid peroxides,347

Aqleh, K. A., see Kaufman, R. D.,

73

Arbel, E. R. and Glick, G.: Effectsof veratnine on the in situ dog

heart: Evidence for increased

ventricular fibrillation

threshold, 314

Arceneaux, J. E. L., see Pitt, C.G., 12

Anrhythmias, ventricular, digi-taIls-induced, role of fore-

brain noradrenergic mecha-nisms, 57

Arteries, renal, canine, tensionand 45Ca fluxes, differing ac-

tions of nitroprusside and D-

600 on, 155Asano, M. and Hidaka, H.: Con-

tractile response of isolatedrabbit aortic strips to unsat-urated fatty acid peroxides,

347Autonomic nervous system, influ-

ence on production of cere-

brospinal fluid in cat, 341Ayala, J. M., see Nascimento, L.,

522

Baer, P. G., Kauker, M. L. andMcGiff, J. C.: Prostacyclin ef-fects on renal hemodynamicand excretory functions in

the rat, 294

Baiie, M. D., Alward, C. T., Saw-yer, D. C. and Hook, J. B.:

Effect of anesthesia on car-

diovascular and renal func-

tion in the newborn piglet,

298Baines, A. D., Craan, A., Chan, W.

and Morgunov, N.: Tubular

secretion and metabolism of

dopamine, norepinephnne,

methoxytyramine and nor-

metanephnne by the rat kid-

ney, 144Baldino, F., Jr., Cowan, A., Geller,

E. B. and Adler, M. W.: Ef-

fects of antipsychotic and an-

tianxiety drugs on the mor-

phine abstinence syndromein rats, 63

Baldoni, F., see Tallanida, G., 319

Baquero, R. A., see Nascimento,L., 522

Barkai, A. I.: Serotonin turnoverin the intact rabbit brain: Re-lationship to extracellular

proteins and modification by

pentobarbital or haloperidol,44

Barlow, T. S., see Vogel, R. A.,

161

Barnes, D. W., Morahan, P. 5.,Loveless, S. and Munson, A.E.: The effects of maleic an-

hydnide-divinyl ether (MVE)copolymers on hepatic micro-somal mixed-function oxi-

dases and other biologic ac-tivities, 392

Behavioral effects

of chlorpromazine alone and in

combination with differentmorphine treatments in rats,

67

of LSD on learning measuredby classical conditioning of

rabbit nictitating membraneresponse, 330

of methadone during pregnancyin rat offspring, 106

thyrotropin-releasing hormone

on locomotor activit, operant

performance and ingestivebehavior, 161

Bell, R. D., see Cicero, T. J., 210Bellin, S. I., see Edmonds, H. L.,

Jr., 236Beilville, J. W., see Kaufman, R.

D., 73

Benzhydryl piperazines, anticon-

vulsant effects on maximalelectroshock seizures in rats,480

Berman, W., Jr. and Musselman,J.: The relationship of age tothe metabolism and protein

binding of digoxin in sheep,263

Bernstein, S. P., see Deneke, S.

M., 377Bile

excretion of [‘4Cjphenytoin inrat, effect of pregnancy, 257

excretion of sulfobromophthal-em, rat, effect of inhibition ofenzymatic activity of ligan-

din, by organometals, 248Biotransformation, of BCNU, ef-

fect of phenobarbital pre-treatment, 1

1,3-Bis (2-chioroethyl) 1-nitrosou-rea (BCNU), antitumor ac-tivity and plasma pharmaco-kinetics and biotransforma-tion, effect of phenobarbitalpretreatment, 1

Blatnick, R. A., see Pace, N. L.,254

Blood pressure, systolic in exper-imental hypertension in rats,

effects of antihypertensivetreatment, 310

Blunden, M., see Vore, M., 257Bohidar, N. R., see Scriabine, A.,

148

Bondinell, W., see Pendleton, R.G., 24

Bordetella pertussis vaccine, del-eterious effect on metabolismand disposition of phenytoin,267

Bradycardia, prostaglandin E1-in-

duced, in rats, effects of brainserotonin alterations, 232

528 Index

Bradykinin, intra-arterial injec-tion in rabbit hindlimb, car-diovascular and respiratory

chemoreflexes, 319

Brainy-aminobutyric acid neurons in

caudatus, pallidus and mgra,

effects of opioids and dopa-

mine agonists, 190dopamine, depletion by 6-hy-

droxydopamine, effect on tol-erance to anorexic effect of d-

amphetamine and fenflura-

mine in rats, 143

guanosine 3’,5’-monophosphate

content, change by thyrotro-pin-releasing hormone, 169

homogenates, rat, tele-methyl-histamine oxidation by type

B monoamine oxidase, 422intact, rabbit, relationship of

serotonin turnover to extra-cellular proteins and modi.fl-cation by phenobarbital orhaloperidol, 44

mouse, catecholamine-sensitiveadenosine triphosphatase,effects of acute and continu-ous morphine administration,

80rat, comparison of cytochrome

P-450-dependent aminopy-

rime N-demethylase with he-patic aminopyrine N-de-methylation, 271

rat, morphine persistence aftersingle doses, 228

rat striatum, endogenous phos-phorylation on synaptic

plasma membrane proteins,effect of morphine, 96

regional concentrations of do-pamine and dihydroxyphen-ylacetic acid, effects of drugs,

44noradrenergic mechanisms, role

in digitalis-induced arrhyth-miss, 57

serotonin alterations, effects onprostaglandin E1-inducedbradycardia in rats, 232

Braswell, L., see Savarese, J. J.,436

Breese, G. R.see Hollister, A. S., 37

see Mailman, R. B., 169see Vogel, R. A., 161

Brindisi, F., see Tallarida, G., 319Bronchodilator, new (pirbuterol),

pharmacokinetics and cardi-opulmonary effects in dogs,371

Butanol, tertiary, physical de-pendence in mice, quantita-tively compared with ethanol

and correlated with lipid sol-ubiity, 113

Byers, B. R., see Pitt, C. G., 12

Byington, K. H. and Hansbrough,E.: Inhibition of the enzy-

matic activity of ligandin byorganogermanium, organo-

lead or organotin compounds

and the biiary excretion ofsulfobromophthalein by the

rat, 248Byrd, A., see Levin, V. A., 1

Calcium-dependent activator of

cyclic nucleotide phosphodi-esterase, selective binding ofantipsychotics and other psy-

choactive agents to, 454

Calcium-45, fluxes in canine renalarteries, differing actions of

nitroprusside and D-600, 155

Cangiano, J. L., RodrIguez-Sar-

gent, C. and MartInez-Mal-

donado, M.: Effects of anti-hypertensive treatment onsystolic blood pressure and

renin in experimental hyper-tension in rats, 310

Cardiopulmonary effects, of sub-

lingual pirbuterol, new bron-chodilator, in dogs, 371

Cardiovascular function, in new-born piglet, effect of anesthe-sia, 298

Cardiovascular responses, fromhindlimb sensory receptors

evoked by intra-arterial in-jection of bradykinin andother chemical agents in rab-bit, 319

Cat(s)forebrain noradrenergic mech-

anisms and digitalis-inducedventricular arrhythmias, 57

influences of autonomic ner-vous system on production ofcerebrospinal fluid, 341

neuromuscular junction, ac-

tions of phenylene diacryloylbis-cholinium esters, 436

spinal serotornn terminal sys-tern mediating antinocicep-

tion, 446tubulin assembly, axonal ultra-

structure and fast axoplasmictransport, nocodazole action,411

Catecholamine(s)-sensitive adenosine triphos-

phatase in mouse brain, ef-fects of acute and continuousmorphine treatment, 80

tubular secretion and metabo-lisrn by rat kidney, 144

transmission blockade and

stimulation of gangliomcadenylate cyclase by, 31

fl-Cells, islets of Langerhans, Ef-fect of pH on selectivity of

alloxan for, 184Central nervous system

noradrenergic mechanisms, rolein digitalis-induced ventricu-lar arrhythmias, 57

phenylethanolamine N-meth-yltransferase, effects ofSK&F 29661, 24

Cerebrospinal fluid, production,cat, influences of autonomicnervous system, 341

Cerrito, F., see Raiten, M., 195

Cervoni, A. M., see Raiteri, M.,195

Chan, W., see Baines, A. D., 144Chelating agents, new, for treat-

ment of iron overload, selec-

tion and evaluation, 12

Chemoreflexes, cardiovascular

and respiratory, from hind-limb sensory receptors

evoked by intra-arterial in-jection of bradykinin andother chemical agents in rab-bit, 319

Cheney, D. L., see Moroni, F., 190Chlordiazepoxide, effects on mor-

phine abstinence syndrome

in rats, 63Chlorisonidamine-induced renin

release in conscious rat, me-diation by adrenergic mech-

anisms, 3031-(2-Chloroethyl)-3-cyclohexyl-1-

nitrosourea (CCNU), antitu-mor activity, effect of pheno-barbital pretreatment, 1

1-(2-Chloroethyl)-3-(2,6-dioxo-3 - piperidyl - 1 - nitrosourea(PCNU), antitumor activity,

effect of phenobarbital pre-treatment, 1

Chlorpromazinealone and in combination with

different morphine treat-ment, behavioral effects inrats, 67

Chlorpromazine, effects on mor-phine abstinence syndromein rats, 63

Cho, A. K., see Fischer, J. F., 203Cicero, T. J., Meyer, E. R and

Bell, R D.: Effects of ethanolon the hypothalamic-pitui-tary-luteinizing hormone axisand testicular steroidogene-sis, 210

Classical conditioning, of rabbit

nictitating membrane re-sponse, as measure of LDSeffects on learning, 330

Clineschmidt, B. V., McKendry,

M. A., Papp, N. L., Pflueger,A. B., Stone, C. A., Totaro, J.A. and Williams, M.: Stereo-

specific antidopaminergicand anticholinergic actions ofthe enantiomers of (±)-1-cy-clopmpylmethyl-4-(3-trifluo-

romethylthio - 5H - dibenzo-[a,d}cyclohepten-5-ylidene)piperidine (CTC), a deriva-tive of cyproheptadine, 460

Clomdine, effects on glucose andphosphate metabolism inanesthetized dog, 243

Clouet, D. H., see O’Callaghan, J.

P., 96

Colby, H. D., see Kramer, R E.,19

Commissiong, J., see Robinson, S.E., 476

Connors, M., see Wainer, B. H.,498

Constantine, J. W., Mcflhenny, H.M. and Moore, P. F.: Phar-macokinetics and cardiopul-monary effects in dogs of sub-lingual pirbuterol, a new

bronchodilator, 371

Cooper, B. R, see Vogel, R. A.,161

Cooperstein, S. J., see Watkins,D., 184

Costa, E., see Moroni, F., 190Cowan, A., see Baldino, F., Jr., 63Craan, A., see Baines, A. D., 144

Crabbe, J. C., Rigter, H., Uijlen,

J. and Strijbos, C.: Rapid de-velopment of tolerance to the

hypothermic effect of ethanolin mice, 128

Crumbliss, A. L., see Pitt, C. G.,12

CTC, (±)-1-cyclopropylmethyl-4-(3 - trifluoromethylthio - 5H-dibenzo[a,d]cyclohepten-5-

ylidene) piperidine (cypro-heptradine derivative), en-antiomers, stereospecific an-

tidopaminergic and anticho-linergic actions, 460

Cyclic nucleotide phosphodiester-

ase, calcium-dependent acti-vator, selective binding of an-tipsychotics and other psy-choactive agents to, 454

Cyproheptadine, derivative, CTC,enantiomers, stereospecificantidopaminergic and anti-cholinergic actions, 460

Cytochrome P-450-dependentaminopyrine N-demethylasein rat brain, comparison withhepatic aminopyrine N-de-methylation, 271

D-600, effects on tension and �Cafluxes in canine renal arteries,comparison with nitroprus-side, 155

Daniell, H. B., Walle, T., Gaffney,T. E. and Webb, J. G.: Stim-

ulation-induced release ofpropranolol and norepineph-tine from adrenergic neurons,354

Davis, B. B., see Zenser, T. V., 418N-Demethylation, aminopyrine,

cytochrome P-450-depen-dent, in rat brain, comparisonwith hepatic, 271

Deneke, S. M., Bernstein, S. P.and Fanburg, B. L: Enhance-ment by disulfiram (Ants-buse) of toxic effects of 95 to

97% 02 on the rat lung, 377Desaiah, D. and Ho, I. K.: Effects

of acute and continuous mor-phine administration on cat-echolamine-sensitive adeno-sine triphosphatase in mousebrain, 80

Desmck, R. J., see Hudson, L. D.S., 507

Diazepam, effects on morphineabstinence syndrome in rats,

632,4-Dichiorophenoxyacetic acid,

renal handling by winter

flounder, 280Digitalis-induced ventricular ar-

rhythmias, role of forebrainnoradrenergic mechanisms,57

Digoxin, metabolism and proteinbinding in sheep, relationshipto age, 263

Dihydroxyphenylacetic acid, re-

gional brain concentrations,effects of drugs, 44

L-DihydroxypheflylalalUfle-stlIn-

ulated activity, role of mono-amine neural systems, 37

Index 529

N, N- Dimethyl-4-aminoazoben-zene, hepatobiliary fate, rolefor liver glutathione, 399

Disposition, of phenytoin, delete-rious effect of Bordetella per-

tussis vaccine and poly(rI.

rC),267Disulfiram (Antabuse), enhance-

ment of toxic effects of 95 to97% 02 on rat lung, 377

Diuretic effectsof MK-477, 148on ream release, 522

Dog(s)adrenergic neurons, stimula-

tion-induced release of pro-

pranolol and norepinephrine,354

anesthetized, effects of cloni-

dine on glucose and phos-phate metabolism, 243

effects of histamine on vascu-lax sympathetic neuroeffec-tor transmission, 360

pharmacokinetics and cardio-pulmonary effects of sublin-gnat pirbuterol, new bron-chodilator, 371

pharmacokinetics of naloxoneand naltrexone, 254

renal arteries, tension and �Cafluxes, differing actions of ni-troprusside and D-600 on, 155

ream release by diuretics, 522serum, protein binding of anti-

convulsant drugs, 429

Domino, E. F., see Hough, L. B.,422

Donald, A. G., see Shah, N. S.,491

Donoso, J. A., see Samson, F., 411

Dopaminebrain, depletion by 6-hydroxy-

dopamine, effect on toleranceto anorexic effect of d-am-

phetamine and fenfluramine

in rats, 134chemical release from striate!

homogenates, evidence forexchange diffusion model,203

regional brain concentrations,effects of drugs, 44

release mechanisms, differen-tially affected by dopaminetransport inhibitor nomifen-sine, 195

synthesis, in striatal synapto-somes, effect of haloperidol,468

tubular secretion and metabo-ham by rat kidney, 144

Dopamine agonists, effects on y-

aminobutyric acid neurons incaudatus, palhidus and nigra,190

Dopaminergic systems, develop-ment of functional depend-ence on ethanol, 216

Dvorchick, B. H., see Marietta,

M. P., 271

Eaton, D. L and Klaassen, C. D.:Effects of microsomal en-zyme inducers on carrier-me-diated transport systems inisolated rat hepatocytes, 381

Edmonds, H. L, Jr., Stark, L G.,Stark, D. M., McCormack, C.R., Sylvester, D. M. and Bel-lin, S. I.: The anticonvuLsantactivity of ropizine in the rat,236

$-Endorphineffects, indirectly modulated by

adrenal steroids, 176effects on -y-aminobutyric acid

neurons in caudatus, pallidusand nigra, 190

Enzymatic activity, ligandin, in-

hibition by organometals, oreffect on biiary excretion of

sulfobromophthalein in rat,

248Enzyme

inducers, microsomal, effects oncarrier-mediated transportsystems in isolated rat hepa-

tocytes, 381therapy, immune response in-

duced by enzyme- and buffer-loaded liposomes in C3H/HeJ Gus mice, 507

Esteratic cholinoceptive sites, ac-

tion of phenylene diacryloylbis-cholinium esters, 436

Estes, W. E., see Pitt, C. G., 12

Ethacrynic acid, effect on rernnrelease, 522

Ethanoleffects on hypothalamic-pitui-

tary-luteinizing hormone axisand testicular steroidogene-sis, 210

functional dependence, devel-opment in dopaminergic sys-tems, 216

hypothermic effect in mice,rapid development of toler-ance, 128

physical dependence in mice,quantitatively comparedwith tertiary butanol and cor-related with lipid solubiity,

113

withdrawal reactions in mice,suppressed by sodium bro-mide and sodium valproate,223

Excretory functions, rat, effects of

prostacyclin, 294

Fanburg, B. L., see Deneke, S. M.,377

Fanelli, G. M., Jr., see Scriabine,

A., 148Fatty acid, peroxides, unsatu-

rated, contractile response ofisolated rabbit aortic strips,347

Fenfluramine, anorexic effect, tol-erance to, effect of depletionof brain dopamine by 6-hy-droxydopamine, 134

Fentanyl, intravenous, relativepotency and duration of ac-tion with respect to respira-tory depression in man, 73

Fiddler, M. B., see Hudson, L. D.S., 507

Fiel, S., see Watkins, D., 184Finkeistein, T. T., see Levine, W.

G., 399Finn,A.,seeLevin,V.A., 1

Finn, A. M., see Mullis, K. B., 228Fischer, J. F. and Cho, A. K.:

Chemical release of dopa-

mine from striate! homoge-nates: Evidence for an ex-change diffusion model, 203

Flounder, winter, renal handlingof 2,4-dichlorophenoxyaceticacid, 280

Fry, W. J., see Hester, R. K., 155

Frye, G. D., see Mailman, R. B.,

169Fung, H-L., see Lettieri, J. T., 7

Furosemide, tubular secretion, re-lated to saluretic effect, 515

Gaffney, T. E., see Daniell, H. B.,354

Gaines,C.G.,seePitt,C.G., 12

Ganglia, rat superior cervical,transmission blockade andstimulation of adenylate cy-

clase by catecholamines, 31Geller, E. B., see Baldino, F., Jr.,

63Gessner, G., see Pendleton, R. G.,

24Gills, R. A., see Helke, C. J., 57Gimpl, M. P., Gormezano, I. and

Harvey, J. A.: Effects of LSD

on learning as measured byclassical conditioning of therabbit nictitating membraneresponse, 330

Ginsburg, S., see Savarese, J. J.,436

Glick, G., see Arbel, E. R., 314Glover, W. E., see Neering, I. R.,

335Glucose, metabolism in anesthe-

tized dog, effects of clonidine,243

Glutathione, liver, role in hepa-tobiiary fate of N,N-di-methyl-4-aminoazobenzene,

399Goldfish, functional tolerance of

pentobarbita!, 123Goldman, P., see Koch, R. L., 406

Goldstein, D. B.: Sodium bromideand sodium valproate: Effec-tive suppressants of ethanolwithdrawal reactions in mice,223

Goldstein, D. B., see McComb, J.A., 113

Gonadal hormone, effects on he-patic drug metabolism in

rats, role of pituitary gland,19

Gorinson, H. S., see Hutchings, D.E., 106

Gormezano, I., see Gimpi, M. P.,330

Greiner, J. W., see Kramer, R. E.,19

Greizerstein, H. B.: Developmentof functional tolerance topentobarbit.al in goldfish, 123

Guanosme 3’,5’-monophosphatecontent, brain, change bythyrotropin-releasing hor-mone, 169

Gudzinowicz, M. J., see Porter, W.

R., 386Gupta,G.,seePitt,C.G., 12

Haloperidoleffect on dopamine synthesis

and tyrosine hydroxylase instriatal synaptosomes, 468

effects on morphine abstinencesyndrome in rats, 63

modification of serotonin turn-over in intact rabbit brain,relationship to extracellularproteins, 44

Halushka, P. V., see Hsu, C. Y.,

366Hansbrough, E., see Byington, K.

H., 248Hartman, R. D., see Marietta, M.

P., 271

Harvey, J. A., see Gimpl, M. P.,

330Haywood, J. R. and Vogh, B. P.:

Some measurements of au-

tonomic nervous system in-fluence on production of cere-brospinal fluid in the cat, 341

Heart, ventricular arrhythmias,digitalis-induced, role of fore-brain noradrenergic mecha-nisms, 57

Heffner, T. G. and Seiden, L. S.:The effect of depletion ofbrain dopamine by 6-hydrox-ydopamine on tolerance tothe anorexic effect of d-am-phetamine and fenfluraminein rats, 134

Helke, C. J., Zavadil, A. P., III andGills, R. A.: Forebrain nor-adrenergic mechanisms and

digitalis-induced ventricular

arrhythmias, 57Heller-Bettinger, I., see Samson,

F., 411Hemodynamics, renal, rat, pros-

tacyclin effects, 294Hemosiderosis, treatment, selec-

tion and evaluation of newiron chelating agents, 12

Hen, relationship between tubu-lax secretion of furosemideand its saluretic effect, 515

Hepatocytes, isolated, rat, carrier-mediated transport systems,effect of microsomal enzyme

inducers, 381Hester, R. K., Weiss, G. B. and

Fry, W. J.: Differing actionsofnitroprusside and D-600 ontension and “�Ca fluxes in ca-nine renal arteries, 155

Hidaka, H., see Asano, M., 347

Himes, R H., see Samson, F., 411

Hindhimb, sensory receptors, rab-bit, cardiovascular and respi-ratory chemoreflexes evokedby intra-arterial injection ofbradykinin and other chemi-cal agents, 319

Histamine, effects on vascularsympathetic neuroeffector

transmission, 360Ho, I. K., see Desaiah, D., 80Hoffman, P. L., see Tabakoff, B.,

216Holaday, J. W., Law, P-Y., Loh,

H. H. and Li, C. H.: Adrenalsteroids indirectly modulatemorphine and f1-endorphineffects, 176

530 Index

Hollister, A. S., Breese, G. R. andMueller, R. A.: Role of mono-amine neural systems in L-di-hydroxyphenylalanine-stim-

ulated activity, 37Hook, J. B., see Baiie, M. D., 298Hough, L. B. and Domino, E. F.:

Tele-methylhistamine oxida-tion by type B monoamine

oxidase, 422

Hsu, C. Y., Knapp, D. R. and Hal-ushka, P. V.: The effects ofalpha adrenergic agents on

human platelet aggregation,366

Hudson, L. D. S., Fiddler, M. B.

and Desnick, R. J.: Enzymetherapy. X. Immune re-sponse induced by enzyme-and buffer-loaded liposomesin C3H/HeJ Gus” mice, 507

Humphreys, M. H. and Reid, I.A.: Effects of clonidine onglucose and phosphate me-tabolism in the anesthetizeddog, 243

Hunt, H. F., see Hutchings, D. E.,

106Hutchings, D. E., Towey, J. P.,

Gorinson, H. S. and Hunt, H.F.: Methadone during preg-nancy: Assessment of behav-ioral effects in the rat off-spring, 106

Hydralazine, effects on systolic

blood pressure and renin inexperimental hypertension inrats, 310

6-Hydroxydopamine-induced de-pletion of brain dopamine, ef-

feet on tolerance to anorexiceffect of d-amphetamine andfenfluramine in rats, 134

N-(2-Hydroxyethyl)-oxamic acid,metabolite of metronidazole,anaerobic metabolism, 406

Hypnotic effects, of sodium -y-hy-

droxybutyrate in rat, 7

Hypotension, drug-induced, in

conscious rat, renin releasedduring, mediation by adren-ergic mechanisms, 303

Hypothalamic-pituitary-luteiniz-ing hormone axis, effects ofethanol, 210

Hypothermic effects, ofethanol in

mice, rapid development of

tolerance, 128

Immune response, induced by en-zyme- and buffer-loaded Ii-posomes in C3H/HeJ Gus

mice, 507

Intoccia, A., see Pendleton, R. G.,24

Iron, overload, treatment, selec-tion and evaluation of new

chelating agents, 12

Islets of Langerhans, fl-cells, ef-

feet of pH on selectivity ofalloxan for, 184

James, M. 0., see Pritchard, J. B.,

280

Jenkins, B., see Pendleton, R. G.,24

Kapatos, G. and Zigmond, M. J.:

Effect of haloperidol on do-pamine synthesis and tyro-

sine hydroxylase in striate!synaptosomes, 468

Kaufman, R. D., Aqleh, K. A. andBeIlville, J. W.: Relative po-

tencies and durations of ac-

tion with respect to respira-

tory depression of intrave#{149}nous meperidine, fentanyland alphaprodine in man, 73

Kauker, M. L., see Baer, P. G..294

Keeton, T. K. and Pettinger, W.A.: The domanance of adren-ergic mechanisms in mediat-ing hypotensive drug-in-duced renin release in theconscious rat, 303

Kidneyfunction in newborn piglet, ef-

fect of anesthesia, 298hemodynamics and excretory

functions in rat, prostacyclineffects, 194

isolated, perfused, rat, trans-

port of 2,4,5-trichlorophen-oxyacetate, 287

rabbit, metabolism of organic

compounds, demonstrationof separate pathways, 418

rat, levo-methadone distribu-tion during postnatal devel-

opment, 491rat, tubular secretion and me-

tabolism by dopamine, nor-epinephrine, methoxytyra-

mine and normetanephrine,144

tubular secretion of furosemide,related to sa!uretic effect, 515

winter flounder, handling of 2,4-dichlorophenylacetic acid,280

Kitz, R. J., see Savarese, J. J., 436Klaassen, C. D., see Eaton, D. L.,

381Klemfuss, H., Tallarida, R J., Ad-

ler, C. H. and Adler, M. W.:Morphine-induced mydriasis

and fluctuation in the rat:Time and dose relationships,91

Knapp, D. R., see Hsu, C. Y., 366Koch, R. L. and Goldman, P.: The

anaerobic metabolism ofmetronidazole forms N-(2-

hydroxyethyl)-oxamic acid,

406

Koschier, F. J. and Acara, M.:Transport of 2,4,5-trichloro-phenoxyacetate in the iso-lated, perfused rat kidney,287

Kramer, R. E., Greiner, J. W.,Rumbaugh, R. C., Sweeney,T. D. and Colby, H. D.: Re-quirement of the pituitarygland for gonadal hormoneeffects on hepatic drug me-tabolism in rats, 19

Law,P-Y.,seeHoladay,J.W., 176

Lau, C. and Slotkin, T. A.: Accel-erated development of ratsympathetic neurotransmis-

sion caused by neonatal tri-iodothyronine administra-

tion, 485Leander, J. D., see Lucot, J. B., 67Learning, effects of LSD mea-

sured by classical condition-ing ofrabbit nictitating mem-brain response, 330

Lettieri, J. T. and Fung, H-L.:Dose-dependent pharmaco-

kinetics and hypnotic effectsof sodium y-hydroxybutyratein the rat, 7

Leucine enkephalin, effects onmorphine-induced analgesia,acute tolerance and depend-ence, comparison with methi-onine enkephalin, 76

Levi, G., see Raiteri, M., 195

Levis, R. M. and Weiss, B.: Selec-tive binding of antipsychoticsand other psychoactiveagents to the calcium-depen-

dent activator of cyclic nu-cleotide phosphodiesterase,454

Levis, V. A., Stearns, J., Byrd, A.,Finn, A. and Weinkam, R. J.:The effect of phenobarbitalpretreatment on the antitu-mor activity of 1,3-bis-(2-chloroethyl)- 1-nitrosourea(BCNU), 1-(2-chloroethyl)-3-cyclohexyl- 1-nitrosourea(CCNU) and 1-(2-chloro-ethyl)-3-(2,6-dioxo-3-piperi-dyl)-1-nitrosourea (PCNU),and on the plasma pharma-cokinetics and biotransfor-mation of BCNU, 1

Levine, W. G. and Finkelstein, T.T.: A role for liver glutathi-one in the hepatobiiary fateof N,N-dimethyl-4-amino-azobenzene, 399

Li, C. H., see Holaday, J. W., 176

Lieberman, M. M., see Pace, N.L., 254

Ligandin, enzymatic activity, in-hibition by organometals, ef-feet on biiary excretion ofsulfobromophthalein, 248

Lin,M.,seeRosen,T.S., 118

Lin, M. T.: Effects of brain sero-tonin alterations on prosta-

glandin E1-induced bradycar-dia in rats, 232

Lipid solubility, correlation withphysical dependence on ter-tiary butanol and ethanol inmice, 113

Liposomes, enzyme- and buffer-loaded, immune response inC3H/HeJ Gus mice, 507

Liveraminopyrine N-demethylation,

comparison with cytochromeP450-dependent aminopy-rise N-demethylase in rat

brain, 271drug metabolism, rats, role of

pituitary gland in gonadalhormone effects, 19

glutathione, role in hepatobili-ary fate of N,N-dimethyl-4-aminoazobenzene, 399

microsomal mixed-function ox-idases, effects of maleic an-hydride-divinyl ether cops!-ymers, 392

necrosis, thioacetamide-in-duced, rat, 386

rat, carrier-mediated transport

systems, effects of micro-somal enzyme inducers, ‘381

rat, levo-methadone distribu-tion during postnatal devel-opment, 491

Locomotor activity, i�-dihydroxy-

phenylalanine-stimulated,role of monoamine neuralsystems, 37

Loh, H. H., see Holaday, J. W.,176

L#{246}scher,W.: A comparative studyof the protein binding of an-ticonvulsant drugs in serum

of dog and man, 429

Loveless, S., see Barnes, D. W.,392

LSD, effects on learning mea-sured by classical condition-ing ofrabbit mctitating mem-brane response, 330

Lucot, J. B., McMillan, D. E. andLeander, J. D.: The behav-ioral effects of chlorproma-zine alone and in combina-tion with different morphinetreatments in rats, 67

Ludden, C. T., see Scriabine, A.,

148Lung

rat, levo-methadone distribu-tion during postnatal devel-opment, 491

rat, toxic effects of95 to 97% 02,enhancement by disulfiram,

377

Mailman, R. B., Frye, G. D.,Mueller, R. A. and Breese, 0.R: Change in brain gua-nosine 3’,5’-monophosphate(cGMP) content by thyrotro-pin-releasing hormone, 169

Maleic anhydride-divinyl ethercopolymers, effects on he-patic microsomal mixed-function oxidases and otherbiologic activities, 392

Malthe-Sorenssen, D., see Robin-son, S. E., 476

Manplatelet aggregation, effects of

alpha adrenergic agents, 366serum, protein binding of anti-

convulsant drugs, 429

Marietta, M. P., Vesell, E. S.,Hartman, R D., Weiss, J. andDvorchik, B. H.: Characteri-zation of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain:Comparison with hepatic am-inopyrine N-demethylation,271

Martinez-Maldonado, M.see Cangiano, J. L., 310see Nascimento, L., 522

Mattammal, M. B., see Zenser, T.V., 418

Index 531

Maximal electroshock seizures,rats, anticonvulsant effects ofbenzhydryl piperazines, 480

McComb, J. A. and Goldstein, D.B.: Quantitative comparisonof physical dependence ontertiary butanol and ethanolin mice: Correlation withlipid solubility, 113

McCormack, C. R., see Edmonds,H. L., Jr., 236

McGiff, J. C., see Baer, P. G., 294Mcllhenny, H. M., see Constan-

tine, J. W., 371

McKendry, M. A., see Chine-schmidt, B. V., 460

McMillan, D. E., see Lucot, J. B.,67

Meperidine, intravenous, relative

potency and duration of ac-tion with respect to respira-tory depression in man, 73

Metabolismand protein binding of digoxin

in sheep, relationship to age,

263anaerobic, of metromdazole

forms N-(2-hydroxyethyl)-oxamic acid, 406

hepatic drug, rats, role of pitui-tary gland in gonadal hor-mone effects, 19

hepatobiiary, of N,N-dimethyl-4-aminoazobenzene, role for

liver glutathione, 399of glucose and phosphate in

anesthetized dog, effects ofchonidine, 243

of levo-methadone during post-natal development in rat, 491

of organic compounds in rabbitkidney, demonstration of sep-

arate pathways, 418of phenytoin, deleterious effect

of Bordetella pertussis vac-cine and poly(rI . rC), 267

of thioacetamide to thioaceta-mide-S-oxide in rat, relatedto thioacetamide-induced he-patic necrosis, 386

Methadone, during pregnancy,behavioral effects in rat off-spring, 106

levo-Methadone, pharmacologi-cal effects and metabolic fate

during postnatal develop-ment in rat, 491

Methionine enkephalin, effects onmorphine-induced analgesia,acute tolerance and depend-ence, comparison with methi-onine enkephalin, 86

Methoxytyramine, tubular secre-tion and metabolism by ratkidney, 144

3-Methylcholanthrene, effects on

carrier-mediated transport

systems in isolated rat hepa-

tocytes, 381

a-Methyldopa, effects on systolicblood pressure and renin inexperimental hypertension in

rats, 310tele-Methylhistamine, oxidation

by type B monoamine oxi-

dase, 422

Metolazone, effects on renin

release, 522

Metronidazole, metabolite N-(2-

hydroxyethyl)-oxamic acid,anaerobic metabolism, 406

Metterville, J. J., see Pitt, C. 0.,12

Meyer, E. R., see Cicero, T. J., 210Mice

brain, catecholamine-sensitiveadenosine triphosphatase, ef-fects of acute and continuousmorphine administration, 80

C3H/HeJ Gus, immune re-sponse induced by enzyme-and buffer-loaded liposomes,507

development of functional de-pendence on ethanol in do-paminergic systems, 216

differential effects of leucine

and methionine enkephalinon morphine-induced anal-gesia, acute tolerance and de-pendence, 85

effects of maleic anhydrode-di-vinyl ether copolymers on he-patic microsomal mixed-

function oxidases and other

biologic activities, 392ethanol withdrawal reactions

suppressd by sodium bromide

and sodium valproate, 223physical dependence on tertiary

butanol and ethanol, quan-tatively compared and corre-hated with lipid solubiity, 113

selection and evaluation of new

chelating agents for treat-ment of iron overload, 12

Microsomes, hepatic, mixed-func-tion oxidases, effects of mal-

eic anhydrode-divinyl ethercopolymers, 392

Microtubules, nocodazole action,411

MK-447 [2-aminoethyl-4-(1,1-di-methyl)-6-iodophenol hydro-

chloride], diuretic and anti-

hypertensive effects, 148Monkey, squirrel, SK&F 29661,

organ-specific inhibitor ofphenylethanolamine N-methyltransferase, 24

Monoamine neural systems, rolein i-dihydroxyphenylala-

nine-stimulated activity, 37Monoamine oxidase, type B, oxi-

dation of tele-methylhistam-

me, 422Moore, K. E., see Umezu, K., 49

Moore, P. F., see Constantine, J.W., 371

Morahan, P. 5., see Barnes, D.W., 392

Morgunov, N., see Baines, A. D.,144

Moroni, F., Peralta, E., Cheney,D. L. and Costa, E.: On theregulation of -y-aminobutyric

acid neurons in caudatus, pal-hidus and nigra: Effects ofopioids and dopamine ago-nists, 190

Morphineabstinence syndrome, rats, ef-

fects of antipsychotic and an-

tianxiety drugs, 63

acute and continuous adminis-tration, effects on catechol-

amine-sensitive adenosinetriphosphatase in mousebrain, 80

effects, indirectly modulated byadrenal steroids, 176

effects on -y-aminobutyric acidneurons in caudatus, pallidusand nigra, 190

effects on endogenous phospho-rylation of synaptic plasma

membrane proteins of ratstriatum, 96

in combination with ch!orpro-maxine, behavioral effects inrats, 67

-induced analgesia, acute toler-ance and dependence, differ-ential effects of leucine andmethionine enkephalin, 86

-induced mydriasis and fluctua-tion in rat, time and dose re-lationships, 91

persistence in rat brain and se-rum after single doses, 228

Mueller, R. A.see Hollister, A. S., 37see Mailman, R. B., 169see Vogel, R. A., 161

Mullis, K. B., Perry, D. C., Finn,A. M., Stafford, B. and Sad#{233}e,W.: Morphine persistence inrat brain and serum after sin-

gle doses, 228Munson, A. E., see Barnes, D. W.,

392

Muscle

smooth, isolated rabbit aorticstrips, contractile response tounsaturated fatty acid per-oxides, 347

smooth, vascular, contraction,role of sulthydryl groups, 335

Musselman, J., see Berman, W.,Jr., 263

Mydriasis, morphine-induced, rat,time and dose relationships,91

Naloxone, pharmacokinetics indog, 254

Nascimento, L., Ayala, J. M., Ba-quero, R. A. and Martinez-Maldonado, M.: Reninrelease by diuretics, 522

Neal, R. A., see Porter, W. R., 386

Necrosis, hepatic, thioacetamide-induced, rat, 386

Neering, I. R. and Glover, W. E.:

The role of sulfhydryh groupsin contraction of vascularsmooth muscle, 335

Neuromuscular junction, actions

of phenylene diacryloyl bis-

chohinium esters, 436

Neuronsadrenergic, stimulation-in-

duced release of propranololand norepinephrine, 354

y-aminobutyric acid, in cauda-tus, pallidus and nigra, effects

of opioids and dopamine ag-

onists, 190

monoamine, role in L-dihydrox-yphenylalanine-stimulatedactivity, 37

Nictitating membrane response,

rabbit, classical conditioning,as measure of LSD effects on

learning, 330Nitroprusside, effects on tension

and 45Ca fluxes in caninerenal arteries, comparisonwith D-600, 155

Nocodazole, action on tubulin as-sembly, axonal ultrastructureand fast axoplasmic trans-port, 411

Nomifensine, dopamine transportinhibitor, differential effectson dopamine release mecha-nisms, 195

Nordquest, K. W., see Pitt, C. 0.,

12

Norepinephrine

stimulation-induced releasefrom adrenergic neurons, 354

tubular secretion and metabo-lism by rat kidney, 144

Normetanephrine, tubular secre-tion and metabolism by ratkidney, 144

Novack, G. D., Stark, L. G. andPeterson, S. L.: Anticonvul-

sant effects of benzhydryl pi-perazines on maximal elec-

troshock seizures in rats, 480

O’Cal!aghan, J. P., Williams, N.

and Clouet, D. H.: The effectof morphine on the endoge-nous phosphorylation of syn-aptic plasma membrane pro-teins of rat striatum, 96

Odhind, B.: Relationship betweentubular secretion of furose-mide and its saluretic effect,515

Opioidsantibodies (antimorphine and

antimeperidine), specificityand reactivity with opioidpeptides, 498

effects of -y-aminobutyric acidneurons in caudatus, palhidusand nigra, 190

Organometals (organogerman-

ium, organolead or organo-tin), inhibition of enzymaticactivity of higandin by, effecton biliary excretion of sulfo-bromophthalein in rat, 248

Oxidation, of tele-methylhistam-ine by type B monoamine ox-idase, 422

Oxygen, toxicity, rat lung, en-hancement by disulfiram, 377

Pace, N. L, Parrish, R. G., Lie-berman, M. M., Wong K. C.and Blatnick, R. A.: Phar-macokinetics of naloxone andnaltrexone in the dog, 254

Palmer, R. A., see Pitt, C. 0., 12Papp, N. L., see Chineschmidt, B.

V., 460

Parrish, R. 0., see Pace, N. L., 254Pendleton, R. G., Gessner, 0.,

Weiner, G., Jenkins, B., Saw-yer, J., Bondinell, W. and In-

532 Index

toccia, A.: Studies on SK&F29661, an organ-specific in-hibitor of phenylethanola-mine N-methyltransferase,24

Pentobarbit.al, functional toler-

ance in goldfish, 123Peptides, reactivity with antimor-

phine and antimeperidineantibodies, 498

Peralta, E., see Moroni, F., 190

Perry, D. C., see Mullis, K. B., 228Peruzzi, G., see Tallarida, G., 319Peterson, S. L., see Novack, G. D.,

480Pettinger, W. A., see Keeton, T.

K., 303Pflueger, A. B., see Clineschmidt,

B. V., 460

Pharmacokineticsdose-dependent, of sodium y-

hydroxybutyrate in rat, 7of naloxone and naltrexone in

dog, 254of sublingual pirbuterol, new

bronchodilator, in dogs, 371

of thioacetamide and thioacet-amide-S-oxide in rat, 386

plasma, of BCNU, effect ofphenobarbitalpretreatment, 1

Phenobarbita.!

effects on carrier-mediatedtransport system in isolatedrat hepatocytes, 381

modification of serotonin turn-over in intact rabbit brain,relationship to extracellularproteins, 44

pretreatment, effect on antitu-mor activity of BCNU,CCNU and PCNU and onplasma pharmacokineticsand biotransformation ofBCNU, 1

Phentolamine-induced renin re-lease in conscious rat, media-tion by adrenergic mecha-nisms, 303

Phenylene diacrylolyl bis-chohi-nium esters, actions at neu-romuscular and esteraticchohinoceptive sites, 436

Phenylethanolamine N-methyl-transferase organ-specific in-hibitor (SK&F 29661), 24

Phenytoin, metabolism and dis-position, deleterious effect ofBordetella pertussis vaccineand poly(rI . rC), 267

[“C]Phenytoin, biiary excretionin rat, effect of pregnancy,257

Phosphate, metabolism in anes-thetized dog, effects of cloni-dine, 243

Phosphorylation, endogenous, ofsynaptic plasma membrane

proteins of rat striatum, ef-feet of morphine, 96

Physical dependence

functional, development in do-

paminergic systems, 216on ethanol in mice, withdrawal

reactions suppressed by so-

dium bromide and sodium

valproate, 223on morphine, differential ef-

fects of leucine and methio-nine enkephalin, 86

on tertiary butanol and ethanolin mice, quantitatively com-pared and correlated withlipid solubility, 113

Piglet, newborn, cardiovascularand renal function, effect ofanesthesia, 298

Pitt, C. G., Gupta, G., Estes, W.E., Rosenkrantz, H., Metter-ville, J. J., Crumbliss, A. L.,Palmer, R. A., Nordquest, K.W., Sprinkle Hardy, K. A.,Whitcomb, D. R, Byers, B.

R., Arceneaux, J. E. L.,Gaines, C. G. and Sciortino,C. V.: The selection and eval-uation of new chelatingagents for the treatment ofiron overload, 12

Pituitary gland, role in gonadalhormone effects on hepaticdrug metabolsm in rats, 19

Pirbuterol (new bronchodilator),sublingual, pharmacokinetics

and cardiopulmonary effectsin dogs, 371

Platelet aggregation, human, ef-fects of alpha adrenergic

agents, 366Poly(rI . rC), deleterious effect on

metabolism and dispositionof phenytoin, 267

Porter, W. R., Gudzinowicz, M. J.and Neal, R. A.: Thioaceta-mide-induced hepatic necro-sis. II. Pharmacokinetjcs ofthioacetamide and thioacet-amide-S-oxide in the rat, 386

Powell, J. R.: Effects of histamineon vascular sympathetic neu-roeffector transmission, 360

Prange, A. J., Jr., see Vogel, R. A.,161

Pregnancyeffect on biliary excretion of

[‘4Cjphenytoin in rat, 257methadone during, behavioral

effects on rat offspring, 106rat, maternal, fetal and neo-

natal effects of chronic pro-

pranolol, 118

Pregnenolone- 16a-carbonitrile,

effects on carrrier-mediatedtransport systems in isolatedrat hepatocytes, 381

Pritchard, J. B. and James, M. 0.:Determinants of the renalhandling of 2,4-dichlorophen-oxyacetic acid by winterflounder, 280

Propranololchronic administration, in rat,

maternal, fetal and neonataleffects, 118

stimulation-induced release

from adrenergic neurons, 354Prostacyclin, effects on renal he-

modynamics and excretoryfunctions in rat, 294

Prostaglandin E1-induced brady-cardia in rats, effects of brain

serotonin alterations, 232

Protein(s)binding and metabolism of di-

goxin in sheep, relationshipto age, 263

binding, of anticonvulsantdrugs in serum of dog and

man, 429

extracellular, relationship toserotonin turnover in intact

rabbit brain and its modifi-cation by phenobarbital andhaloperidol, 44

synaptic plasma membrane, ratstriatum, endogenous phos-phorylation, effects of mor-phine, 96

Pupil, rat, time and dose relation-ships of morphine-induced

mydriasis and fluctuation, 91

Quenzer, L., Yahn, D., Alkadhi,K. and Voile, R. L.: Tram-mission blockade and stimu-

lation ofganglionic adenylatecyclase by catecholamines, 31

Rabbit(s)hindlimb sensory receptors,

cardiovascular and respira-

tory chemoreflexes evoked

by intra-arterial injection of

bradykinin and other chemi-cal agents, 319

intact brain, relationship of ser-otonin turnover to extracel-

lular proteins and modifica-

tion by phenobarbital or

haloperidol, 44

isolated aortic strips, contrac-tile response to unsaturated

fatty acid peroxides, 347

kidney, metabolism of organiccompounds, demonstrationof separate pathways, 418

nictitating membrane response,

classical conditioning, as

measure of LSD effects on

learning, 330

role ofsulthydryl groups in con-traction of vascular smooth

muscle, 335

spinal serotonin terminal sys-tem mediating antinocicep-tion, 446

Raimondi, G., see Tallarida, G.,

319

Raiteri, M., Cerrito, F., Cervoni,

A. M. and Levi, G.: Dopa-mine can be released by twomechanisms differentially af-fected by the dopamine

transport inhibitor nomifen-

sine, 195

Rats

adrenal steroids indirectly mod-

ulating morphine and fl-en-dorphin effects, 176

anaerobic metabolism of met-romdazole forms N-(2)-hy-

droxyethyl)-oxamic acid, 406

anticonvulsant activity of ro-

pazine, 236behavioral effects of chlorpro-

maxine alone and in combi-nation with different mor-

phine treatments, 67biliary excretion of [‘4C]pheny-

toin, effect of pregnancy, 257brain and serum, morphine per-

sistence after single doses,228

brain, comparison of cyto-chrome P450-dependent

aminopyrine N-demethylasewith hepatic aminopyrine N-demethylation, 271

brain guanosine 3’,S’-mono-phosphate content, changeby thyrotropin-releasing hor-

mone, 169

brain homogenates, tele-meth-ylhistamine oxidation bytype B monoamine oxiddse,422

conscious, hypotensive drug-in-

duced renin release, media-tion by adrenergic mecha-nisms, 303

chemical release of dopaminefrom striate! homogenates,evidence for exchange diffu-

sion model, 203deleterious effect of Bordetella

pertussis vaccine and poly-(rI . rf�) on metabolism anddisposition of phenytoin, 267

differential effects of dopaminetransport inhibitor nomifen-sine on dopamine releasemechanisms, 195

diuretic and antihypertensiveeffects of MK-447, 148

dopaminergic control of septal-hippocampal cholinergicpathway, 476

dose-dependnet pharmacoki-

netics and hypnotic effects ofsodium y-hydroxybutyrate, 7

effects of depletion of brain do-

pamine by 6-hydroxydopa-mine on tolerance to anorexiceffect of d-amphetamine andfenfluramine, 134

effects of haloperidol on dopa-mine synthesis and tyrosine

hydroxylase in striate.! syn-

aptosomes, 468

effects of drugs on regionalbrain concentrations of do-pamine and dihydroxyphen-ylacetic acid, 44

effects of opioids and dopamineagonists on regulation of y-aminobutyric acid neurons incaudatus, pallidus and mgra,190

effects of phenobarbita! pre-treatment on antitumor ac-tivity of BCNU, CCNU and

PCNU and on plasma phar-

macokinetics and biotrans-formation of BCNU, 1

effects of thyrotropin-releasinghormone on locomotor activ-ity, operant performance and

ingestive behavior, 161

experimental hypertension,

systolic blood pressure andream in, effect of antihyper-tensive treatment, 310

Index 533

isolated hepatocytes, carrier-

mediated transport systems,

effects of microsomal enzymeinducers, 381

isolated, perfused kidney, trans-port of 2,4,5-trichlorophen-oxyacetate, 287

kidney, tubular secretion andmetabolism of dopamine,norepinephrine, methoxytyr-

amine and normetanephrine,144

lung, toxic effects of 95 to 97%02, enhancement by disulfi-ram, 377

male, effects of ethanol on hy-pothalamic-pituitary-lutein-

izing hormone axis and testic-ular steroidogenesis, 210

maternal, fetal and neonatal ef-fects of chronic propranolol,118

maximal electroshock seizures,anticonvulsant effects ofbenzhydryl piperazines, 480

morphine abstinence syn-drome, effects of antipsy-chotic and antianxiety drugs,63

offspring, behavioral effects ofmethadone during preg-nancy, 106

pharmacokinetics of thioaceta-mide and thioacetamide-S-oxide, related to thioaceta-mide-induced hepatic necro-515, 386

postnatal development, phar-macological effects and met-abolic fate of levo-metha-done, 491

prostaglandin E1-induced bra-dycardia, effects of brain ser-

otonin alterations, 232renal hemodynamics and excre-

tory functions, prostacychineffects, 294

role for liver glutathione in he-patobiliary fate of N,N-di-methyl-4-aminoazobenzene,

399

role of monoamine neural sys-tems in L-dihydroxyphenyl-alanine-stimulated activity,37

role of pituitary gland in go-nadal hormone effects on he-patic drug metabolism, 19

SK&F 29661, organ-specific in-

hibitor of phenylethanola-

mine N-methyltransferase,

24

spinal serotonin terminal sys-tem mediating antinocicep-

tion, 446stereospecific antidopaminergic

and antichohinergic actions of

enantiomers of CTC, cypro-heptadine derivative, 460

striatum, endogenous phospho-rylation of synaptic plasmamembrane proteins, effect ofmorphine, 96

sympathetic neurotransmis-

sion, accelerated develop-

ment caused by neonatal tri-

iodothyrornne administra-

tion, 485thioacetamide-induced hepatic

necrosis, 386time and dose relationships of

morphine-induced mydriasisand fluctuation, 91

transmission blockade andstimulation of ganghiomcadenylate cyclase by cate-cholamines, 31

Receptorsadrenergic, alpha, human

platelets, 366

dopaminergic, control of septal-hippocampal chohinergicpathway, 476

sensory, hindhimb, rabbit car-

diovascular and respiratory

chemoreflexes evoked by in-tra-arterial injection ofbradykinin and other chemi-

cal agents, 319

Reid, I. A., see Humphreys, M.H., 243

Release mechanismschemical, of dopamine from

striatal homogenates, evi-dence for exchange diffusionmodel, 203

dopamine, differentially af-fected by dopamine transportinhibitor nomifensine, 195

Reninin experimental hypertension in

rats, effects of antihyperten-sive treatment, 310

release by diuretics, 522

release, hypotensive drug-in-duced, in conscious rat, me-diation by adrenergic mech-

anisms, 303Renton, K. W.: The deleterious

effect of Bordetella pertussis

vaccine and poly(rI . rC) onthe metabolism and disposi-tion of phenytoin, 267

Respiratory depression, man, rel-ative potencies and durations

of action of intravenous me-peridine, fentanyl and al-phaprodine, 73

Respiratory responses, from hind-limb sensory receptors

evoked by intra-arterial in-jection of bradykinin andother chemical agents in rab-bit, 319

Rigter, H., see Crabbe, J. C., 128Robinson, S. E., Malthe-S#{248}rens-

sen, D., Wood, P. L. and

Commissiong, J.: Dopami-nergic control of the septal-hippocampal chohinergicpathway, 476

Rodriguez-Sargent, C., see Cangi-ano,J.L.,310

Ropazine, anticonvulsant activity

in rat, 236Rosen, M. R., see Rosen, T. S.,

118

Rosen, T. S., Lin, M., Spector, S.and Rosen, M. R.: Maternal,

fetal and neonatal effects of

chronic propranolol adminis-

tration in the rat, 118Rosenkrantz, H., see Pitt, C. G.,

12

Rothberg, R M., see Wainer, B.H., 498

Rumbaugh, R. C., see Kramer, R.E., 19

Russo, H. F., see Scriabine, A.,148

Sad#{233}e,W., see Mullis, K. B., 228Samson, F., Donoso, J. A., Heller-

Bettinger, I., Watson, D. andHimes, R. H.: Nocodazole ac-tion on tubulin assembly, ax-onal ultrastructure and fastaxoplasmic transport, 411

Sangiorgi, M., see Tallarida, 0.,

319

Savarese, J. J., Ginsburg, S., Bra-swell, L and Kitz, R. J.: Ac-tions at neuromuscular andesteratic cholinoceptive sites

of some phenylene diacryloylbis-cholinium esters, 436

Sawyer, D. C., see Baiie, M. D.,298

Sawyer, J., see Pendleton, R. G.,24

Sciortino, C. V., see Pitt, C. 0., 12Scriabine, A., Watson, L. S.,

Russo, H. F., Ludden, C. T.,Sweet, C. S., Fanelli. 0. M.,

Jr., BOhidar, N. R. and Stone,C. A.: Diuretic and antihy-pertensive effects of

2-aminoethyl-4-(1,1-dimeth-

ylethyl)-6-iodophenol hydro-chloride (MK-447), 148

Seiden, L. S., see Heffner, T. C.,134

Seizures, experimental, in rats,

anticonvulsant activity of ro-

pazine, 236

Septal-hippocampal chohinergicpathway, dopaminergic con-

trol, 476

Serotoninbrain, alterations, effects on

prostaglandin E1-inducedbradycardia in rats, 232

terminal system, spinal, me-

diating antinociception, 446turnover in intact rabbit brain,

relationship to extraceilular

proteins and modification bypentobarbital or haloperidol,

44Serum, rat, morphine persistence

after single doses, 228Shah, N. S. and,, Donald, A. 0.:

Pharmacological effects and

metabolic fate of levo-meth-

adone during postnatal de-velopment in rat, 491

Sheep, metabolism and proteinbinding of digoxin, relation-ship to age, 263

SK&F 29661, organ-specific inhib-

itor of phenylethanolamine

N-methyltransferase, 24

Slotkin, T. A., see Lau, C., 485Sodium bromide, suppressant of

ethanol withdrawal reactionsin mice, 223

Sodium -y-hydroxybutyrate, dose-

dependent pharmacokineticsand hypnotic effects in rat, 7

Sodium valproate, suppressant ofethanol withdrawal reactionsin mice, 223

Sohiven, E., see Vore, M., 257Spector, S., see Rosen, T. S., 118Spinal cord, serotonin terminal

system, mediating antinoci-

ception, 446Spleen, rat, leuo-methadone dis-

tribution during postnatal de-velopment, 491

Sprinkle Hardy, K. A., see Pitt, C.

0., 12Stark, D. M., see Edmonds, H. L.,

Jr., 236Stark, L. 0.

see Edmonds, H. L., Jr., 236see Novack, G. D., 480

Stafford, B., see Mullis, K. B., 228Stearns, J., see Levin, V. A., 1

Steroidogenesis, testicular, effects

of ethanol, 210Steroids, adrenal, indirectly mod-

ulating morphine and fl-en-dorphin effects, 176

Stimulation-induced release ofpropranolol and norepineph-rine from adrenergic neurons,354

Stone, C. A.see Clineschmidt, B. V., 460

see Scriabine, A., 148Striatum

homogenates, chemical release

of dopamine, evidence for ex-

change diffusion model, 203rat, endogenous phosphoryla-

tion of synaptic plasma mem-

brane proteins, effects ofmorphine, 96

synaptosomes, dopamine syn-

thesis and tyrosine hydrox-ylase, effect of halperidol, 468

Strijbos, C., see Crabbe, J. C., 128Sulfliydryl groups, role in contrac-

tion of vascular smooth mus-cle, 335

Sulfobromophthalein, biliary ex-cretion, rat, effect of inhibi-tion of enzymatic activity of

ligandin by organometals,248

Sweeney, T. D., see Kramer, R.E., 19

Sweet, C. S., see Scriabine, A., 148

Sylvester, D. M., see Edmonds, H.L., Jr., 236

Sympathetic nerves, transmis-sion, effects of histamine, 360

Sympathetic nervous system, rat,

accelerated developmentcaused by neonatal triiodo-thyronine administration,

485

Synaptic plasma membrane, pro-

teins, rat striatum, effect of

morphine on endogenousphosphorylation, 96

Synaptosomes, striatal, dopaminesynthesis and tyrosine hy-

534 Index

droxylase, effect of haloperi-dol, 468

Synthesisdopamine, in striate.! synapto-

somes, effect of haloperidol,468

Tabakoff, B. and Hoffman, P. L.:Development of functionaldependence on ethanol in do-paminergic systems, 216

Takemori, A. E., see Vaught, J.

L., 86

Tallarida, G., Baldoni, F., Peruzzi,0., Brindisi, F., Raimondi, G.

and Sangiorgi, M.: Cardiovas-cular and respiratory chemo-reflexes from the hindlimbsensory receptors evoked byintra-arterial injection ofbradykinin and other chemi-cal agents in the rabbit, 319

Tallarida, R. J., see Klemfuss, H.,

91

Tension, canine renal arteries, dif-fering actions of nitroprus-

side and D-600, 155Testes, steroidogenesis, effects of

ethanol, 210

Thioacetamide-induced hepatic

necrosis in rat, 386Thioridazine, effects on morphine

abstinence syndrome in rats,63

Thyrotropin-releasing hormoneeffects on locomotor activity,

operant performance andingestive behavior, 161

-induced change in brain gua-nosine 3’,5’-monophosphate

content, 169Toadfish, effect of pH on selectiv-

ity of alloxan for fl-cells of

islets of Langerhans, 184

Toleranceacute, morphine, differential ef-

fects of leucine and methio-nine enkephalin, 86

functional, to pentobarbital in

goldfish, 123

rapid development, to hypo-

thermic effect of ethanol inmice, 128

to anorexic effect of d-amphet-

amine and fenfluramine in

rats, effect of depletion ofbrain dopamine by 6-hydrox-ydopamine, 134

Totaro, J. A., see Clineschmidt, B.V., 460

Towey, J. P., see Hutchings, D.E., 106

Toxicity, of 95 to 97% 02 in ratlung, enhancement by disul-

firam, 377

Transmission, blockade, gangli-omc, by catecholamines, 31

2,4,5-Trichlorophenoxyacetate,transport in isolated, per-

fused rat kidney, 287Triiodothyronine, � neonatal, as

cause of accelerated devel-opment of rat neurotransmis-sion, 485

Tyrosine hydroxylase, in striate.!

synaptosomes, effect of halo-peridol, 468

Uijlen, J., see Crabbe, J. C., 128Umezu, K. and Moore, K. E.: Ef-

fects of drugs on regional

brain concentrations of do-pamine and dihydroxyphen-ylacetic acid, 49

Vasoconstriction

rabbit ear arteries, role ofsulfhydryl groups, 335

sympathetic, effects of hista-mine, 360

Vaught, J. L and Takemori, A.E.: Differential effects of leu-cine and methionine enkeph-alin on morphine-induced an-algesia, acute tolerance anddependence, 86

Vesell, E. S., see Marietta, M. P.,271

Vogel, R. A., Cooper, B. R., Bar-low, T. S., Prange, A. J., Jr.,Mueller, R A. and Breese, G.R.: Effects of thyrotropin-re-leasing hormone on locomo-tor activity, operant perform-ance and ingestive behavior,161

Vogh, B. P., see Haywood, J. R.,

341Voile, R. L., see Quenzer, L., 31

Vore, M., Soliven, E. and Blun-den, M.: The effect of preg-nancy on the biliary excretion

of [‘4C]phenytoin in the rat,257

Wainer, B. H., Wung, W. E., Con-nors, M. and Rothberg, R.

M.: The specificity of anti-morphine and antimeperi-dine antibodies and theirreactivity with opioid pep-tides, 498

Walle, T., see Daniell, H. B., 354

Watkins, D., Cooperstein, S. J.and Fiel, S.: Studies on theselectivity of alloxan for thefl-cells of the islets of Langer-

hans: Effect of pH on the invitro action of alloxan, 184

Watson, D., see Samson, F., 411Watson, L S., see Scriabine, A.,

148

Webb, J. G., see Daniell, H. B.,354

Weiner, C., see Pendleton, R 0.,

24

Weinkam, R. J., see Levin, V. A.,

Weiss, B., see Levin, R. M., 454Weiss, G. B., see Hester, R K.,

155

Weisz, J., see Marietta, M. P., 271

Whitcomb, D. R., see Pitt, C. G.,12

Williams� M., see Clineschmidt, B.

V., 460

Williams, N., see O’Callaghan, J.P., 96

Wilson, P. R, see Yaksh, T. L,

446Withdrawal, from ethanolin mice,

suppressed by sodium bro-

mide and sodium valproate,223

Wong, K. C., see Pace, N. L, 254Wood, P. L, see Robinson, S. E.,

476

Wung, W. E., see Wainer, B. H.,498

Yahn, D., see Quenzer, L, 31

Yaksh, T. L. and Wilson, P. R.:Spinal serotonin terminalsystem mediates antinocicep-

tion, 446

Zavadil, A. P., III, see Helke, C.J., 57

Zenser, T. V., Mattammal, M. B.and Davis, B. B.: Demonstra-tion of separate pathways forthe metabolism of organiccompounds in rabbit kidney,418

Zigmond, M. J., see Kapatos, G.,468