View
219
Download
1
Tags:
Embed Size (px)
Citation preview
I
V
I
V
The inferior olivary nucleus is the only source of cerebellar climbing fibers
The Inferior Olive nucleus
Olivary neurons (Ramon Y Cajal)
Intracellular labeling of olivary neuron HRP filled olivary neuron
Action potential in olivary neuron
Action potentials in olivary neuron
The effect of TTX on action potentials in olivary neuron
The effect of Mn2+ and Cd2+ on action potentials in olivary neuron
-68 mV
-60 mV
-60 mV
-55 mV
Two types of action potentials in olivary neuron
20 msec
1 nA
15 mV15 mV
-60 mV
The Na+ and Ca2+ components of the two types of action potentials
TTX
Independent activation of the action potentials
Refractory period of the action potentials
10 mV
Refractory period of the action potentials
The Inactivation curve of the low threshold action potential
Possible mechanism of rhythmic activity
Ionic currents in Olivary neurons:
Na current – typical H&H current
Dendritic Ca current – high threshold non-inactivating
Ca dependent, K current
Somatic Ca current – low threshold inactivating
Possible mechanism of rhythmic activity
Cell 1 Cell 2
Cell 1
Cell 2
10 mV5
200 ms
10 mV
20 mV
Cell 1
Cell 25 mV
200 ms
Cell 1
Cell 22 mV
100 ms
20 mV
Electrical coupling between olivary neuron
Dye coupling between olivary neuron
The olivary glumerulus
Olivary Gap junction