Hyperuricemia & Hyperuricemia & NutritionNutritionDr Brain Gantoro, M.Gizi, SpGKDr Brain Gantoro, M.Gizi, SpGKGout (monosodium urate Gout (monosodium urate deposition):deposition): - Gout aects !" o t#e popu$ation- Gout aects !" o t#e popu$ation- %redominant$y ma$es (&" ema$es)- %redominant$y ma$es (&" ema$es)- 'ommon in men o(er )*yrs and postmenopausa$- 'ommon in men o(er )*yrs and postmenopausa$

ema$esema$es- Hi+# pre(a$ance in certain racia$ +roups (e+ Maori)- Hi+# pre(a$ance in certain racia$ +roups (e+ Maori)- Gout is common$y associated ,it# #yperuricaemia- Gout is common$y associated ,it# #yperuricaemia- 'ommon$y aects t#e oot- 'ommon$y aects t#e oot-./0121G3: -./0121G3: /ends to tar+et pre(ious$y dama+ed 4oints/ends to tar+et pre(ious$y dama+ed 4oints 5e$ates to en(irnmenta$ temperature uric acid is $ess 5e$ates to en(irnmenta$ temperature uric acid is $ess so$u6$e in coo$er temperatueso$u6$e in coo$er temperatue Systemic: romSystemic: rom accumu$ation o monosodium urate crysta$s accumu$ation o monosodium urate crysta$s into sot tissues into sot tissues N7'2.1/0D.S: 0ntrace$$u$ar 2o, mo$ecu$ar ,ei+#t Bioc#emica$$y acti(eN7'2.1/0D.S: %urine: -denine Guanine Hypo8ant#ine 9ant#ine %yrimidine: 'ytosine /#ymine 7racy$The major purine bases present in nucleotidesThe 3 majorpyrimidinebases found innucleotidesHACELL TGGluGlu-6PGlu-1.6PF-1.6PTriosa-PPyrGly TGGliLaktat Ac.CoAFAMevalonatKholesterolKREBSCO2H2OATPLaktatHATIKetonN7'2.1S0D.S: Nuc$eotides:%urine%yrimidine Su+ar:5i6oseDe-o8y-ri6ose-D.N1S0N.-/50-%H1S%H-/. (-/%)G17/:G17/: -:uired #yperuricemia: %rimary Gout: 7rate production Secondary Gout: 7rate e8cretion 1t#ers0N'5.-S.D 75-/. 0N'5.-S.D 75-/. %51D7'/01N:%51D7'/01N:HereditaryHereditaryNutrition: Nutrition: .8cess purine.8cess purine .t#ano$.t#ano$ ;ructose ;ructoseHemato$o+ic a6norma$ityHemato$o+ic a6norma$ityDru+s: Dru+s: 'ytoto8ic dru+s, 'ytoto8ic dru+s, .t#ano$ .t#ano$ 1t#ers: 1t#ers: 16esity 16esityD.'5.-S.D 5.N-2 D.'5.-S.D 5.N-2 .9'5./01N:.9'5./01N:Dru+s:Dru+s:.t#ano$, cyc$osporin, t#iazide, .t#ano$, cyc$osporin, t#iazide, urosemide, $e,(odopa, etcurosemide, $e,(odopa, etc5ena$:5ena$:Hypertention, po$ycystic Hypertention, po$ycystic