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Cover image from the AGI Therapeutics Annual Report 2008

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Design for:

Anaesthesia / Intensive Care Medicine, Cardiology, Cardio-

Thoracic Surgery, Dermatology, Diabetes / Endocrinology,

Gastroenterology, General Surgery, Gynaecology, Haematology,

Hepatology, Infectious Diseases, Neurology, Neurosurgery,

Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic

Surgery, Otorhinolaryngology /ENT, Pain Management, Plastic

Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders

Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive

Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology,

Diabetes / Endocrinology, Gastroenterology, General Surgery,

Gynaecology, Haematology, Hepatology, Infectious Diseases,

Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology,

Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /

ENT, Pain Management, Plastic Surgery, Respiratory Medicine,

Rheumatology, Sleep Disorders Medicine, Urology and Vascular

Surgery.Anaesthesia / Intensive Care Medicine, Cardiology,

Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology,






Medicine, Urology and Vascular Surgery.Anaesthesia / Intensive





Oral Surgery, Orthopaedic Surgery, Otorhinolaryngology /


















Surgery. Anaesthesia / Intensive Care Medicine, Cardiology,




















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Gastroenterology, General Surgery, Gynaecology, Haematology, rGastroenterology, General Surgery, Gynaecology, Haematology, rGastroenterology, General Surgery, Gynaecology, Haematology, PGastroenterology, General Surgery, Gynaecology, Haematology, PGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, rGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, iGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, vGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, aGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, tGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, aGastroenterology, General Surgery, Gynaecology, Haematology, tGastroenterology, General Surgery, Gynaecology, Haematology, aGastroenterology, General Surgery, Gynaecology, Haematology,

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Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, pCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, iCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, iCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, tCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, tCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, aCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, lCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, ·Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, ACardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology,

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Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, cSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, /Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, /Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, pSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, rSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, iSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, vSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, aSurgery. Anaesthesia / Intensive Care Medicine, Cardiology,

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parRheumatology, Sleep Disorders Medicine, Urology and Vascular rRheumatology, Sleep Disorders Medicine, Urology and Vascular tRheumatology, Sleep Disorders Medicine, Urology and Vascular tRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular nRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular eRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular rRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular sRheumatology, Sleep Disorders Medicine, Urology and Vascular hRheumatology, Sleep Disorders Medicine, Urology and Vascular hRheumatology, Sleep Disorders Medicine, Urology and Vascular

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ENT, Pain Management, Plastic Surgery, Respiratory Medicine, tENT, Pain Management, Plastic Surgery, Respiratory Medicine, tENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, wENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, eENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, eENT, Pain Management, Plastic Surgery, Respiratory Medicine,

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Oral Surgery, Orthopaedic Surgery, Otorhinolaryngology /tOral Surgery, Orthopaedic Surgery, Otorhinolaryngology /

at aeOral Surgery, Orthopaedic Surgery, Otorhinolaryngology /eOral Surgery, Orthopaedic Surgery, Otorhinolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinolaryngology /rOral Surgery, Orthopaedic Surgery, Otorhinolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinolaryngology /MOral Surgery, Orthopaedic Surgery, Otorhinolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinolaryngology /

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ricoNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, oNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, rNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, dNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, iNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, aNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology,

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Gynaecology, Haematology, Hepatology, Infectious Diseases, iGynaecology, Haematology, Hepatology, Infectious Diseases, vGynaecology, Haematology, Hepatology, Infectious Diseases, vGynaecology, Haematology, Hepatology, Infectious Diseases, Gynaecology, Haematology, Hepatology, Infectious Diseases, eGynaecology, Haematology, Hepatology, Infectious Diseases, Gynaecology, Haematology, Hepatology, Infectious Diseases, rGynaecology, Haematology, Hepatology, Infectious Diseases, Gynaecology, Haematology, Hepatology, Infectious Diseases, sGynaecology, Haematology, Hepatology, Infectious Diseases, Gynaecology, Haematology, Hepatology, Infectious Diseases, iGynaecology, Haematology, Hepatology, Infectious Diseases,

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HoDiabetes / Endocrinology, Gastroenterology, General Surgery, oDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, sDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, pDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, iDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, tDiabetes / Endocrinology, Gastroenterology, General Surgery, aDiabetes / Endocrinology, Gastroenterology, General Surgery, aDiabetes / Endocrinology, Gastroenterology, General Surgery,

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andCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, dCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, MCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, aCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology,

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Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, aCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology,

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Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, aCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology,

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Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive rMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive iMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive vMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive aMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive tMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive aMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive tMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive aMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive

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HoSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders oSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders sSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders pSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders iSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders tSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders

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Surgery, Otorhinolaryngology /ENT, Pain Management, Plastic Surgery, Otorhinolaryngology /ENT, Pain Management, Plastic pSurgery, Otorhinolaryngology /ENT, Pain Management, Plastic Surgery, Otorhinolaryngology /ENT, Pain Management, Plastic uSurgery, Otorhinolaryngology /ENT, Pain Management, Plastic

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Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic pNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic rNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic iNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic vNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic aNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic

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Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic aNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic

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Hepatology, Infectious Diseases, Neurology, Neurosurgery, aHepatology, Infectious Diseases, Neurology, Neurosurgery, aHepatology, Infectious Diseases, Neurology, Neurosurgery, Hepatology, Infectious Diseases, Neurology, Neurosurgery, rHepatology, Infectious Diseases, Neurology, Neurosurgery, Hepatology, Infectious Diseases, Neurology, Neurosurgery, tHepatology, Infectious Diseases, Neurology, Neurosurgery, Hepatology, Infectious Diseases, Neurology, Neurosurgery, nHepatology, Infectious Diseases, Neurology, Neurosurgery,

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Gastroenterology, General Surgery, Gynaecology, Haematology, iGastroenterology, General Surgery, Gynaecology, Haematology, iGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, pGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, bGastroenterology, General Surgery, Gynaecology, Haematology,

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tweCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, eCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, eCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, nCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology,

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at aeSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, eSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, rSurgery. Anaesthesia / Intensive Care Medicine, Cardiology, Surgery. Anaesthesia / Intensive Care Medicine, Cardiology, MSurgery. Anaesthesia / Intensive Care Medicine, Cardiology,

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Rheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular iRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular cRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular oRheumatology, Sleep Disorders Medicine, Urology and Vascular Rheumatology, Sleep Disorders Medicine, Urology and Vascular rRheumatology, Sleep Disorders Medicine, Urology and Vascular

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ENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, UENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, nENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine,

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Gynaecology, Haematology, Hepatology, Infectious Diseases, Gynaecology, Haematology, Hepatology, Infectious Diseases, MGynaecology, Haematology, Hepatology, Infectious Diseases, aGynaecology, Haematology, Hepatology, Infectious Diseases, aGynaecology, Haematology, Hepatology, Infectious Diseases,

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Diabetes / Endocrinology, Gastroenterology, General Surgery, PDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, rDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, iDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, vDiabetes / Endocrinology, Gastroenterology, General Surgery,

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Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive lMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive ·Medicine, Urology and Vascular Surgery. Anaesthesia / Intensive AMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive AMedicine, Urology and Vascular Surgery. Anaesthesia / Intensive

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Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders bSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders lSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders iSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders cSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders /Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders

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Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, aNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, tNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, Neurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, aNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, tNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, aNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, eNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology, eNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology,

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Diabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, sDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, pDiabetes / Endocrinology, Gastroenterology, General Surgery, Diabetes / Endocrinology, Gastroenterology, General Surgery, iDiabetes / Endocrinology, Gastroenterology, General Surgery, tDiabetes / Endocrinology, Gastroenterology, General Surgery, tDiabetes / Endocrinology, Gastroenterology, General Surgery,

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Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, pCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, Care Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology, uCare Medicine, Cardiology, Cardio-Thoracic Surgery, Dermatology,

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Medicine, Urology and Vascular Surgery.Anaesthesia / Intensive pMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive pMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive Medicine, Urology and Vascular Surgery.Anaesthesia / Intensive rMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive Medicine, Urology and Vascular Surgery.Anaesthesia / Intensive iMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive Medicine, Urology and Vascular Surgery.Anaesthesia / Intensive vMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive aMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive aMedicine, Urology and Vascular Surgery.Anaesthesia / Intensive

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Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders aSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders rSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders tSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders Surgery, Respiratory Medicine, Rheumatology, Sleep Disorders nSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders eSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders eSurgery, Respiratory Medicine, Rheumatology, Sleep Disorders

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Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic nNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic MNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic aNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic aNephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic

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Gastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, iGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, aGastroenterology, General Surgery, Gynaecology, Haematology, Gastroenterology, General Surgery, Gynaecology, Haematology, eGastroenterology, General Surgery, Gynaecology, Haematology, UGastroenterology, General Surgery, Gynaecology, Haematology, UGastroenterology, General Surgery, Gynaecology, Haematology,

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Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, rCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, rCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, sCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, iCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, tCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, Cardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, yCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, HCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology, HCardio-Thoracic Surgery, Dermatology, Diabetes / Endocrinology,

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Surgery.Anaesthesia / Intensive Care Medicine, Cardiology, iSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, iSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, Surgery.Anaesthesia / Intensive Care Medicine, Cardiology, tSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, Surgery.Anaesthesia / Intensive Care Medicine, Cardiology, aSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, Surgery.Anaesthesia / Intensive Care Medicine, Cardiology, lSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, Surgery.Anaesthesia / Intensive Care Medicine, Cardiology, aSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, nSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, nSurgery.Anaesthesia / Intensive Care Medicine, Cardiology, d

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Rheumatology, Sleep Disorders Medicine, Urology and Vascular atata e HENT, Pain Management, Plastic Surgery, Respiratory Medicine, HENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, oENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, sENT, Pain Management, Plastic Surgery, Respiratory Medicine, ENT, Pain Management, Plastic Surgery, Respiratory Medicine, pENT, Pain Management, Plastic Surgery, Respiratory Medicine, iENT, Pain Management, Plastic Surgery, Respiratory Medicine, iENT, Pain Management, Plastic Surgery, Respiratory Medicine, tENT, Pain Management, Plastic Surgery, Respiratory Medicine, tENT, Pain Management, Plastic Surgery, Respiratory Medicine,

aENT, Pain Management, Plastic Surgery, Respiratory Medicine,

aENT, Pain Management, Plastic Surgery, Respiratory Medicine,

l· AOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /

AOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /

pOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /

pOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /uOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /bOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /lOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /iOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /cOral Surgery, Orthopaedic Surgery, Otorhinaolaryngology //Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology //Oral Surgery, Orthopaedic Surgery, Otorhinaolaryngology /

ership between Matata er Miser

1. Cover of Corporate Guidelines brochure displaying identity designed for Mater Private Healthcare | 2. Spread from ‘Design Factory — On The Edge Of Europe’ | 3. Cover and spread from the Mater Patient’s Handbook and spread from the Corporate Guidelines brochure | 4. Outdoor signage designed for Mater Private Healthcare | 5. Cover of the Mater PET/CT Centre brochure displaying identity designed for the centre | 6. Illustrations used in the PET/CT brochure | 7. Spreads from the Mater PET/CT brochure


Your PrivacyIf you do not wish people to know that you are a patient in the hospital or if you would like to restrict your visitors or phone calls, please inform admissions staff or a staff member on your ward.

Your Bedroom• All bedrooms are en-suite. Bathroom

facilities are shared in semi-private rooms. Toilets in patients’ rooms are for patient use only. Visitors’ toilets are provided on each ward.

• Hairdryers are not supplied in patient rooms but are available on request from the nurses stations.

• Towels are provided in your room.• Each room is fi tted with a lighting control.• Each room is fi tted with a lighting control.• Each room is fi• The nurse call handset is attached to the

locker beside your bed. • Televisions and radios are located in all

rooms. Headsets are available and in the interests of other patients we ask that these be used.

TelephonesFor your convenience you will have a telephone located beside your bed. To make an outside call dial 9 followed by the number required. All local calls have similar charges to domestic rates and these will be included in your fi nal bill. Two public card-operated in your fi nal bill. Two public card-operated in your fitelephones are located in the main recep-tion area and on Level 2 in the Hospital. Telephone cards can be purchased from the shop located across from the main reception.

The use of mobile phones is not permitted within certain areas of the Hospital, which are indicated by the notices on display.

Incoming/Outgoing MailDuring your stay all incoming mail will be delivered to your room. All mail received after you leave the Hospital will be forwarded to your home address. Pre-stamped letters may be left at the main reception or handed to the staff on your ward who will ensure they are posted on your behalf. Stamps can be purchased in the shop.

Your stay at the hospital

During your stay at the hospital we will do everything we can to make you feel comfortable. If you need anything please do not hesitate to ask a member of staff.

6 Mater Private Hospital Mater Private Hospital 7


Thoracic Surgery, Dermatology, Diabetes / Endocrinology,











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tNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology,

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rNeurology, Neurosurgery, Nephrology, Oncology, Ophthalmology,

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Corporate Identity ManualGUIDELINES FOR ALL PRINTED LITERATURE



















Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic Nephrology, Oncology, Ophthalmology, Oral Surgery, Orthopaedic

Patient Handbook










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Analysis

Strategy

Identity

Implementation

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The starting point for developing the new symbol, was the word itself, ‘MATER’ – meaning ‘Mother’ – and in the Christian context of the Mater Misericordiae University Hospital, meaning the Mother of Christ.

This led us to the ‘Icon Room’ at the National Gallery of Ireland, where various icons feature the Mother of Christ, or the Madonna. The rich colouring of icon painting provided the basis for the choice of colours for the new Mater Private brand. In the tradition of icon painting, gold leaf was often used because of its precious quality. Gold symbolises Divine energy; blue indicates the infi niteness of the sky and red is the colour of heat, passion, love, life and life-giving energy.

A particular painting from the National Gallery of Ireland – Pieta by Pietro Perugino, c.1500 – also provided inspiration for the symbol. The stately arches evoke a sense of place and importance; the soft curved shapes evoke a feeling of calm and caring.

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Letterhead

The Mater Private has a series of letterheads

– one for each division of the group, whereby

the particular logo appears at the top and the

particular address appears at the bottom.

Mater Private Hospital Dublin has an additional

letterhead ‘template’, with its logo at the top

and a blank space at the bottom, where each

department fi lls in their details in their department fi lls in their details in their department fi

on-screen template. Paper: 100gsm Splendorgel

– Paper Assist.

Continuation sheet

The continuation sheet is the same for each

division. Paper: 100gsm Splendorgel –Paper

Assist.

Compliments slip

There is artwork for three compliments

slips – one for each division. Paper: 100gsm

Splendorgel - Paper Assist.

All stationery prints in spot colour only.

V I I S t a t i o n e r y

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Typeface: Verdana Regular.Type size: 8 pt.

Leading (line spacing) for address, date and ‘Re.’ lines: 12 pt.Leading for body of letter: 15 pt.All text bo be range-left, ragged-right.

Left margin: 30mmRight margin: 30mm

Address, date and ‘Re.’ to appear, when possible on top third of page.

Bottom line of address to appear 80mm down for top of page. Therefore, the bottom line will remain the same whether for a short address or a long address. If possible, keep top line of address below 56mm.

Likewise, Date and ‘Re.’ lines to appear 92mm down from top of page.

Body of letter to start, when possible on second third, approx. 104mm down from top of page.

If possible, leave suffi cient space above address line at bottom of page.

Go to continuation sheet after 260mm down from top of page.

V I I S t a t i o n e r y continued

8 December 2005Re. Spec. for letterhead layout

FAO Dr. MurphyDesign Factory100 Capel StreetAnother lineDublin 1Ireland

Dear Dr. Murphy,

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Pieta by Pietro Perugino.Pieta by Pietro Perugino.PietaCourtesy of the National Gallery of Ireland.Courtesy of the National Gallery of Ireland.Inspiration for the mark and identity for Mater Private Healthcare.

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PET IMAGING IS THE FIRST MAJOR CLINICAL APPLICATION PET IMAGING IS THE FIRST MAJOR CLINICAL APPLICATION

OF MOLECULAR IMAGING RESEARCH.OF MOLECULAR IMAGING RESEARCH.

MATER PET/CT CENTRE

16 SLICE HIGH RESOLUTIONPET/CT

PET/CT provides state of the art imaging in Oncology, Cardiology and Neurology, combining functional and PET/CT provides state of the art imaging in Oncology, Cardiology and Neurology, combining functional and

anatomic assessment with excellent image quality. PET/CT is safe, cost effective and has a clinical impact not anatomic assessment with excellent image quality. PET/CT is safe, cost effective and has a clinical impact not

replicated by any other imaging technique. replicated by any other imaging technique.

In comparison to CT alone, Fluorodeoxyglucose (FDG) PET/CT can identify metastases in small lymph nodes, In comparison to CT alone, Fluorodeoxyglucose (FDG) PET/CT can identify metastases in small lymph nodes,

exclude metastasis in larger nodes, identify tumour at sites that are difexclude metastasis in larger nodes, identify tumour at sites that are difexclude metastasis in larger nodes, identify tumour at sites that are difexclude metastasis in larger nodes, identify tumour at sites that are dif cult to assess by CT and can distinguish cult to assess by CT and can distinguish cult to assess by CT and can distinguish

scar tissue from residual tumour. In addition, the extent of radiotracer uptake gives prognostic information based scar tissue from residual tumour. In addition, the extent of radiotracer uptake gives prognostic information based

on the intensity of hypermetabolic activity in tumour deposits. Evaluation of response to treatment is an entirely on the intensity of hypermetabolic activity in tumour deposits. Evaluation of response to treatment is an entirely

new area in Oncology management where PET/CT can predict response to chemotherapy and/or radiotherapy new area in Oncology management where PET/CT can predict response to chemotherapy and/or radiotherapy

prior to completion of treatment. In Cardiology, FDG PET/CT can sensitively identify hibernating myocardium prior to completion of treatment. In Cardiology, FDG PET/CT can sensitively identify hibernating myocardium

and predict response to revascularisation. In Neurology, the metabolic abnormalities identiand predict response to revascularisation. In Neurology, the metabolic abnormalities identi ed on PET/CT ed on PET/CT

commonly precede anatomic changes identicommonly precede anatomic changes identi ed at MRI. ed at MRI.

Major advances in technology in the past decade have brought PET imaging from a primary research setting Major advances in technology in the past decade have brought PET imaging from a primary research setting

to mainstream routine clinical use. PET/CT now realises the full potential of PET Imaging.to mainstream routine clinical use. PET/CT now realises the full potential of PET Imaging.

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PET/CT COST EFFECTIVENESS

Few imaging modalities have been studied as intensively as PET scanning to determine clinical impact. The

decision in healthcare systems around the world to provide coverage indications for PET imaging is also based on

cost effectiveness. The Federal Centres for Medicare and Medicaid services (CMS) in the USA make coverage

decisions after a rigorous evidence-based review process. Indications for PET/CT in Ireland largely mirror those

approved by CMS. The approval process examines the accuracy of PET imaging in comparison to conventional

imaging modalities such as CT and MRI, and considers whether added information yielded by PET/CT can have

an impact in terms of improved patient outcome. In diagnostic investigation terms alone, PET imaging has a clinical

impact and is cost-effective when used for appropriate indications. However the main bene

selection of appropriate treatment. The expense of PET/CT imaging is frequently signi

chemotherapy, radiotherapy and surgery.

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GeneralInformationHealth Insurance

You may be covered fully or in part by your private health insurance. As all health insurance companies and their respective plans differ, we suggest that you call our Accounts Department (Tel: 01 406 3461) and talk to a member of staff in relation to payment. Please bear in mind that accounts will need to be settled in full before leaving the hospital.

Mount Carmel Hospital deals directly with the following insurers:

• VHI (Voluntary Health Insurance)

• Quinn Healthcare (formally BUPA)

• Hibernian AVIVA Health

• ESB Medical Provident Fund

• St. Paul’s Garda Medical Aid

• Non-Insured Patients

Accommodation

Our private and semi-private bedrooms are fully equipped with your comfort in mind. All rooms have en-suite bathroom facilities, telephone, television and bed-side cot for your baby.

Infection Control

Preventing infection in our patients is the principle aim of the infection control department. The department is responsible for coordinating an infection prevention and control programme that meets the specifi c needs of the hospital and its patients.

Good hand hygiene by all is a very effective way of preventing infection.

It is recommended that mothers avoid having false nails as they trap bacteria and natural nails are best kept reasonably short.

For hands that appear clean, waterless alcohol hand gel is very effective for killing microbes. It is rubbed in [one squirt] to all surfaces of dry hands and evaporates rapidly. It is located in patients’ rooms for use by patients, visitors and staff.

If you are coming to the hospital for treatment of an infection, the symptoms of which include diarrhoea and/or vomiting, or a rash please inform the maternity department or nursing administration if possible before you arrive. This will help ensure that suitable accommodation is available.

The following are a few simple steps:

• Remember always to wash your hands after using the toilet and before eating and before feeding your baby and after nappy changing.

• Remember to bring personal toiletries with you. Towels are supplied but you may bring your own if preferred.

• If you are sharing washing facilities be careful to use only your own towel.

• It is recommended that you do not walk around in socks or bare feet. Please bring slippers that have suffi cient grip.

• If you are feeling hot, cold, and shivery do tell a midwife/doctor as you may have a temperature and early detection and treatment is in your best interest.

Advice for visitors

Alcohol hand gel is located in patients’ rooms for use by patients, visitors and staff.

Please help protect our mothers and babies. Do not visit if you or your child has symptoms that you suspect may be caused by an infection, e.g. diarrhoea and/or vomiting, a rash, or cough.

If you need advice about this please feel free to telephone the maternity department before coming to the hospital.

!

1. Identity for the Royal College of Surgeons in Ireland | 2.Cover and spreads of RCSI identity guidelines | 3. Student pamphlet designed for the RCSI | 4. Letterhead and business card for the RCSI | 5. Maternity brochure designed for Mount Carmel.

Practical Information for Your StayWe recommend you prepare a small bag with essential items approximately 4/6 weeks before your expected delivery date. The number of items will vary according to the length of your expected hospital stay. We would ask that you leave all valuables at home.

for mother� 2/3 nightdresses (1 for labour) / pyjamas – front opening preferable

� Light dressing gown

� Slippers

� 2/3 Bras (good support and front opening for breast feeding)

� Comfortable clothes and shoes for going home

� Breast pad (pack) even if not breast feeding

� 6 pairs comfortable pants / disposable pants

� 3 packs of maternity pads

� Freshen up wipes

� Personal toiletries including soap, shampoo, deodorant, hairbrush, etc.

for baby� Stretch suit / Babygrows (0-3 months size) x 10

� Vests x 10

� Baby hat, scratch mitts and socks

� Shawl or blanket

� Cardigan

� Approved car seat for transport home

Mount Carmel supplies disposable nappies, cotton wool and any toiletries for newborn baby.

The Big EventOn admission to Mount Carmel you will meet the midwife who will assess your condition and liaise with the consultant to plan your care. You will meet the obstetrician at the delivery. We support natural childbirth, and also facilitate mothers choice of pain relief.

Analgesia

There are various forms of pain relief for labour. You will be advised and informed during your ante-natal classes. Your midwife will also guide you as labour progresses to your individual preference and needs.

Mount Carmel Hospital is fully equipped to deal with all planned and unplanned events which may arise during your stay. The philosophy of care is to provide quality maternity care in a pleasant environment where each person is treated with respect and dignity.

Paediatric Care

• The Hospital has a team of Consultant Paediatricians, who provide neonatal care for your baby - should this be required. They are supported by a neonatal nursing staff.

• The Maternity Unit has a fully equipped Special Care Baby Unit, suitable for babies over 32 weeks and all emergencies can be catered for in this group. The obstetrician and/or paediatrician may refer babies to the special care baby unit should they decide that a newborn requires special medical attention. Understanding that this situation is a sensitive one, our neonatal nurses give support and are always available to answer questions.

In the Special Care Baby Unit, a paediatrician is available on a 24 hour rota and parents are encouraged to be involved as much as possible in the care of their baby. The team liaise continuously with parents on the care of their newborn. The number of visitors to the SCBU are limited in order to protect your baby from unnecessary infection.

• The vast majority of babies are healthy. Your baby will receive a full physical examination by the Paediatrician, normally the morning after the delivery.

• Mount Carmel is the fi rst hospital to provide Universal Neonatal Hearing screening.

• There is a standard follow up check performed on your infant at six weeks. However if you become anxious concerning your baby at any time during the fi rst six weeks, there are daily clinics and a telephone consultation service available.

The atmosphere is very calm and caring in Mount Carmel. I was in good hands and had a very positive birthing experience.”

Mother of three, Dublin

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When Design Factory met the Royal College of Surgeons fi rst, there was no consistency to the application of their brand identity, indeed the logo mark varied by publication and department. The fi rst step was to undertake a complete communications review, taking every piece of literature, stationery and other items with the College’s details applied, and breaking each down into related groups by style and type. This helped create a hierarchy of items and allowed Design Factory to produce a unifying identity programme. The new and distinctive brand identity had a two-fold function: to encompass the tradition of the college and also make a positive contemporary statement.

The brand was fi rst rolled out into a wide range of printed materials including; stationery, A5 booklets, forms and DL’s amongst many other items. Since the initial branding exercise was completed, RCSI have been successfully producing items of promotional literature, magazines, course details and college information in a clear and consistently applied manner. Design Factory continue to work with the college producing print and digital media.

Stefan’s epic journey

Raceday 2001

Class of 2001

Boston London Chigago

Otolarynology & Physiology Departments

in focus

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spring2002

123 Allah Street, Downtown, Manama, Bahrain.

Telephone +353 1 402 2183 Fax +353 1 402 2182 Email [email protected]

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Philip Curtis MBA

Admissions & Student Services Officer

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When we met with Design Factory, our visual identity lacked consistency and belied our international standing. Design Factory undertook a complete communications review and implemented a cohesive identity programme with brand guidelines, detailing logo, type and colour uses. The result is a new professional and consistent look, which ties together the tradition and future facing outlook of the College, helping us better compete at a global level.”

Design of the Maternity Services brochure

for Mount Carmel.

Design Factory developed a visual concept and colour palette for Maternity Services that differentiated it from the hospital’s other functions. Combined with carefully crafted copy, the brochure offers a look and feel that mirrors the tagline – “A calm safe journey for mother and baby.”

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A calm safe journey for Mother and Baby

Maternity

Maternity A calm safe journey for Mother and Baby

Mount Carmel Hospital

Braemor Park, ChurchtownDublin 14, Ireland

T +353 1 492 2211 / 406 3400F +353 1 492 2094E [email protected]

www.mcm.ie

(1,1) -1- MtCarmelBroch_Cov_AW2.indd 12/06/2009, 12:10:58(1,1) -1- MtCarmelBroch_Cov_AW2.indd 12/06/2009, 12:10:58

AGI Therapeutics, plc. Annual Report & Accounts 2007

0505


Dr Ronan Lambe, Chairman Dr John Devane, Chief Executive Offi cer

Dublin, 1 April 2009

Chairman’s and Chief Executive’s review:

OVERVIEW

2008 was a year of contrasts for AGI. From an operational

standpoint it was a busy and successful year, dominated

by our achievements in progressing the Phase III clinical

development of our lead product candidate, Rezular™.

In addition to managing the ARDIS clinical programme for

Rezular™, we focused considerable time and effort on our

regulatory and intellectual property strategy for this product. We

also engaged in preliminary discussions with potential partners

for this product, having identifi ed a number of companies who

will have suffi cient scale and resources to help us complete

the development of Rezular™ and manage its launch into

the US market.

From a corporate perspective, 2008 was certainly a challenging

year. Our share price, in common with many in our sector,

experienced a precipitous decline in the face of tumultuous

events in the global fi nancial markets. We nonetheless feel

we have made signifi cant progress during 2008 in building

the fundamental value of your company by investing in those

later-stage assets which can potentially yield the greatest

returns if successful in the clinic. We actively communicated

on a regular basis throughout the year with our shareholders

to inform you of progress in the business and we are confi dent

that your patience and support of the AGI team and business

plan will ultimately be rewarded.

Given the uncertainties in the public markets, which restrict

the ability of development-stage companies such as ours

to access further funds at a price acceptable to existing

shareholders, we moved swiftly in 2008 to concentrate our

cash resources on our most advanced programmes. The

considerable progress of Rezular™ is discussed more fully

below, but, where resources allowed, we continued to add

value to certain other products in our pipeline, completing a

successful proof of concept Phase II study for AGI-004 in

the treatment of chemotherapy-induced diarrhoea in cancer

patients, while further optimising our formulation of AGI-010 in

collaboration with our partner, Axcan. While we have not been

able to undertake further clinical trials across the remainder of

the earlier-stage pipeline during 2008, we nonetheless have

continued to invest intellectually in these projects, identifying

new and attractive clinical opportunities to be pursued as and

when additional fi nancial resources become available.

Now, in early 2009, we stand on the verge of the most

signifi cant milestone in our company’s short history, namely

the results from the ARDIS-1 Phase III efficacy study of

Rezular™, which we expect about mid-year. The outcome

of this study will defi ne the effi cacy of this product and will

be anxiously awaited by the AGI team, potential commercial

partners, our shareholders and indeed, patients with this limiting

and underserved disease. Developing a new pharmaceutical

product with blockbuster market potential such as Rezular™

is a major challenge for any company, large or small, in any

environment. However, we believe that the skill, experience,

dedication and enthusiasm of the AGI team, in combination

with the continued support of our Board and shareholders, will

enable us to meet this challenge. Looking beyond Rezular™,

we believe we have amassed a clinical-stage pipeline of

signifi cant potential, which we look forward to being able to

further develop and realise in 2009 and thereafter.

STRATEGY

Our achievements in 2008 were very much in keeping with our

strategy to progress a broad pipeline of compounds through

development for a range of GI diseases. We remain focused

on developing known molecular entities (KME’s) that can be

signifi cantly differentiated from current therapies, and which

will allow us to provide new and innovative products to serve

unmet medical needs in the gastroenterology market. We

maintain our aspiration to develop in the longer term into a

fully integrated specialty pharmaceutical business with the

ability to oversee the sales, marketing and distribution of our

own products in the market by targeting medical specialists

within our therapeutic areas of expertise. We expect to out-

license or partner those products that would benefi t from being

marketed or co-promoted by larger companies, whilst retaining

co-ownership rights to AGI’s products where possible.

OUTLOOK

2009 has started well for AGI. We announced completion of

enrolment of ARDIS-1 for Rezular™ in IBS-D, which is the

fi rst Phase III study to be undertaken by our company and

represents a major achievement on the part of our management

and employees. We also released the preliminary results of our

proof-of-concept study of AGI-004 in CID in the fi rst quarter

which suggests that we have another promising drug in our

portfolio targeted, like Rezular™, at an area of high unmet

medical need.

AG

I Therapeutics

1. Image used in 2008 AGI Therapeutics Annual Report | 2. Photographic details of the 2006 Annual Report | 3. Front Cover and spreads from 2008 Annual Report | 4. Slides from AGI Therapeutics powerpoint presentation | 5. Homepage of AGI Therapeutics website

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A specialty pharmaceutical company focused on the development of new products based on known molecular entities.

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www.agitherapeutics.com


07

Rezular™ (ARVERAPAMIL, AGI-003) IN IBS-D

Irritable bowel syndrome comprises a cluster of gastrointestinal

symptoms which are likely to be life-long and which affect

between 10% and 20% of the population in developed markets.

IBS remains one of the most common diagnoses made by

gastroenterologists and can lead to a substantial reduction in

patients’ quality of life, accompanied by considerable socio-

economic and psychological consequences. Altered intestinal

motility is a major component of IBS and patients are diagnosed

and sub-typed according to their predominant symptom of

bowel disturbance. IBS-D is estimated to occur in one-third

of all IBS patients, and represents a signifi cant unmet medical

need, as there are currently few safe and effective therapeutic

options available to these patients.

Rezular™ is an orally administered multiple mechanism

intestinal regulator, a fi rst-in-class mechanism for the treatment

of IBS-D. Rezular™ contains arverapamil, a single enantiomer

moiety of the racemic drug verapamil. Unlike the currently

available commercial forms of racemic verapamil (a mixture

of two enantiomers), Rezular™ shows a dominant activity

in treating the symptoms of IBS-D without the traditional

cardiovascular actions of the racemic drug. The effi cacy and

safety of Rezular™ in IBS patients has already been established

in a Phase II trial, the preliminary results of which were reported

by the Company in 2006.

Rezular™ is the most advanced product in development for

the treatment of IBS-D in the US, where there is currently only

one available product, Lotronex® (Prometheus/GSK), which is

approved as a limited-access treatment for women only with

severe IBS-D. Hence there is a signifi cant unmet medical need

for new, safe and effective IBS-D treatments and we estimate

the market opportunity for new IBS-D therapies to be greater

than $2.5 Billion in the US alone.

The Phase III development of Rezular™ was our primary focus

in 2008.

We have named the Phase III clinical programme for Rezular™

“ARDIS”. In late 2007, we commenced screening and enrolment

of patients into ARDIS-1, a randomised, double-blind, placebo-

controlled, parallel group effi cacy /safety study in IBS-D patients

(both men and women). There are four treatment arms (placebo

and three dose levels of Rezular™) and patients are treated

for 12 weeks of double-blind therapy. The primary endpoint is

patient global relief of IBS symptoms, as agreed with the US

Food and Drug Administration (FDA). At the end of double-

blind therapy in ARDIS-1, patients become eligible to enrol into

ARDIS-3, a Phase III safety study, which is designed to capture

safety data in a target of 100 patients treated with Rezular™

for 1 year of continuous therapy at the highest dose. By the

end of 2008, 123 clinical centres were enrolling patients in

the United States, Europe and South America for ARDIS-1

and ARDIS-3. ARDIS-1 is the fi rst of two ongoing Phase III

studies which will be included in a future New Drug Application

(NDA) submission to the FDA for approval of Rezular™ in the

U.S. In January 2009, we announced that we had completed

Products

Product Candidate Target Indication Clinical Stage

Preclin Proof of Concept Phase II Phase IlI

Rezular™ (AGI-003) IBS-D

Rezular™ XL IBS-D

(AGI-004) CID

(AGI-010) GERD/NAB

(AGI-022) Ulcerative Colitis

(AGI-006) Functional Dyspepsia

Gastroparesis

Refractory GERD

CINV

Annual Report & Accounts 2008

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Design Factory identifi ed and tied together the key elements that make up the Irish Pharmaceutical Healthcare Association’s brand and designed a brand identity that both shows solid values and contemporary style and accurately refl ects the IPHA’s core remit - to represent the international research-based pharmaceutical industry in Ireland.

Azur P

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1. Identity designed for the Irish Pharmaceutical Healthcare Association | 2. Stationery designed for the IPHA | 3. Pull-up stands designed for the IPHA | 4. Website designed for Azur Pharma

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Your Sincerely,

_________________

John Smyth

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IPHAIRISH PHARMACEUTICALHEALTHCARE ASSOCIATIONwww.ipha.ie

Franklin House140 Pembroke RoadDublin 4Ireland

T (+ 353 1) 6603350F (+ 353 1) 6686672E [email protected] (general enquiries)

E [email protected] (queries about accounts & subscriptions)

The Irish Pharmaceutical Healthcare Association (IPHA) represents the international research-based pharmaceutical industry in Ireland. Our brief was to communicate well-being and innovation as the primary brand message of this organisation. Derived from the ancient fl ower of life pattern and the pattern of basic molecular structure, this symbol projects perfect form, proportion and harmony. It is a symbol of the connections, both scientifi c and technological, which weave throughout our daily lives.

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Design Factory worked closely with Dublin headquartered private pharmaceutical company Azur Pharma, designing and developing the look and navigation structure of their website. As the main information portal for the group, it was essential that Design Factory’s clean design principals were refl ected in the production of this key marketing device.

...well-being and innovation ...

www.azurpharma.com

CPA

, Positive Options, Think C

ontraception

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1. Positive Options leafl et | 2. CPA Strategy brochure | 3. Positive Options poster | 4. Positive Options identity | 5. CPA Keynote booklet | 6. Detail from Crisis Pregnancy Annual Report 2003

1.

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2.

353 1809 0010

Call Design Factory and ask for Conor Clarke or William Hart.

Alternatively, email [email protected] or [email protected]

William Hart is an honours graduate from the University of Kent (UK) where he studied Politics and International Relations. Before joining Design Factory in 2003, he worked in a number of marketing roles, both in the UK and Ireland, planning and overseeing the implementation of marketing strategy and developing new business opportunities. William has worked on all Design Factory’s branding projects for the past 6 years, helping identify strategy and planning for the design stages. These projects have included; The Road Safety Authority, Mater Private Healthcare and Blackpool in Cork amongst others.

Conor Clarke is a Director of Design Factory. He worked at the BRS Design Partnership (now Eden Design & Communications) in Amsterdam before joining Design Factory as a partner in 1985. He has served as a committee member of the SDI (Society of Designers in Ireland) and ICAD (Institute of Creative Advertising and Design). He has been a regular award winner at ICAD with his work featured in international publications such as ‘Who’s who in Graphic Design’ and the ‘New York Directors Club Annual’. Conor specialises in corporate branding.

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100 Capel Street, Dublin 1, Ireland | Tel. +353 1 809 0010 | [email protected] | www.designfactory.ie

Mater Private Healthcare... Mater PET/CT Centre... Royal College of Surgeons in Ireland... Mount Carmel Medical Group... AGI Therapeutics... Irish Pharmaceutical Healthcare Association... Azur Pharma... Crisis Pregnancy Agency... Thérapie... The Bodyclinic

Client List

1. Images used for AGI Therapeutics Annual Reports

1.

Documents

Document