High Throughput Experimentation -Opportunities for Innovation

hte Aktiengesellschaft - Company Overview

Partnering-Veranstaltung Chemie-Start ups

21./22. September 2006

Realizing value in the growing materials market

hte - the high throughput experimentation company

� Advanced materials & technology company, founded 1999, staff ca. 100+

� Development and use of efficient technology platform

� Operational focus» Heterogeneous Catalysis» Homogeneous Catalysis» Formulations and Materials» Adsorption and Separation

� Products» Industrial Research Collaborations» Hardware / Software - Systems» Internal R&D efforts / Materials

Realizing value in the growing materials market

� Very efficient toolbox to design and evaluate materials formulations for target applications

� Core technology: integrated workflow consisting of automated and parallelized synthesis, testing, and data analysis platforms

� Final goal: high productivity R&D to accelerate idea to market (“innovation”)

High Throughput Experimentation

High Throughput Experimentation –Parallelization, Logistics, Creativity

but Nothing Magic

Synthesis, Processing & Characterization

Predictive models Technology Platform MAKE

TEST

Evaluation ofProperty or Properties

MODEL

Experiment & compound design

DESIGN

Prior Information

Prior Information

Synthesis, Processing & Characterization

Predictive models Technology Platform MAKE

TEST

Evaluation ofProperty or Properties

MODEL

Experiment & compound design

DESIGN

Prior Information

Prior Information

Technology Platform MAKE

TEST

Evaluation ofProperty or Properties

MODEL

Experiment & compound design

DESIGN

Prior Information

Prior Information

HTE Goal - Decreasing Time to Market

Lab Scale Pilot Plant Production

Production

time

Micro reactor 10-100g catalystC

onve

ntio

nal

hte solution

hte

Lab Scale /Pilot Plant

Heterogeneous Catalysis A B[Cat.]

� Modern tools for the energy & (petro)chemical industry:

» Control the chemical conversion

» Increase yield of purer products» Save resources and costs» Beneficial for the environment

� > 85% of all (petro-)chemical processes are catalyzed� Total annual catalyst market > 14.500 Mio. USD (5% p.a. growth)� Total created value factor 100 - 500 (approx. 3.000 Bill. Euro)

» Refinery Products, Gasconversion, Petrochemicals & Intermediates» Fine chemicals & Pharma» High tech. materials

� Catalysts R&D still trial and error to a large degree» Efficient and fast development technology needed

� hte’s business focus» Catalysis is key expertise

» Technology platform for applied and efficient catalysis R&D

» hte is successfully positioned in these key market segments

hte in the Catalysis Market

Catalyst Market* 2005: > 14,5 Mrd. USD Growth ca. 5% p.a. , trade sales of heterogeneous catalysts only, Source: Catalyst Group

Refinery & Petrochemicals

23%

Chemicals 23%

Environmental 30%

Polymerization 24%

Petrochemicalsand intermediates,eg. BASF, Eastman

Automotive exhaust treatment,eg. DeNOx and DOC

GTL and refineryapplications, eg. Chevron, Albemarle Polyolefins,

eg. Solvay

hte’s Technology Portfolio

Application optimal tools for an efficient

innovation processSimulation & informatics

Combinatorialchemistry

Parallelization

Advancedanalytics Robotics &

automation

Integrated Laboratory Solutions Business

� Workflow integration business utilizing our demonstrated successful engineering and chemical experience

� hte provides access to dedicated and customized experimental systems validated for target customer chemistry “Turn-key HTE systems and workflows”

Catalysis Formulation

Efficient Formulations– Key Markets and Applications

� Short product and development cycles target efficient (automated) formulation and property screening

Drugs

Paints

Ice cream

Condiments

Detergents

CosmeticsSkin creams

Fertilizers

AdhesivesHerbicides

Cosmeceuticals

Gasoline Lubricants

Catalysts

Conditioners

Resist masks

Oil field

Coatings

Personal Care

Pharmaceutical

Agrochemical

Food

Petrochemical

Specialty Chemical

Environmental

Energy

hte Business is Growing

� hte’s business is growing in all areas:» R&D, Hardware and Software» Catalysis and Formulations

� hte currently uses app. 3700 m² office, lab and workshop space, an expansion opening up additional 1200 m² is under way.

existing hte buildingsexpansion nowexpansion later

hte IP Portfolio

� Strong and growing patent portfolio: 150+ patent applications, 36 granted patents and strong future pipeline

� Focus:» Inventive methods and technology for

High Throughput Experimentation, especially for applied catalysis

» Proprietary materials� Patent strategy:

» Protect own technology solutions and provide add-on value to our customers

» Develop proprietary materials portfolio» Maintain a freedom of operations position relative to hte’s

competitors

hte Aktiengesellschaft – the high throughput experimentation company

� A leading provider of technology and services for enhancing R&D productivity

� Unique & proprietary technology and expertise base

� Operative focus on catalysis, formulations and related advanced materials

� International blue-chip customer base including chemical, environmental, energy and consumer product industry

� Two-fold business model» Profitable R&D-Collaborations & Integrated Systems sales» Reinvest of returns into attractive materials R&D projects

� Value generation and growth as „Advanced Materials & Technology Company“

High productivity R&D for the advanced materials market

Thank You ...

...and all those who have helped to structure and advance our own efforts

For more information:http://www.hte-company.de

Tel. +49(0)62 21.74 97-0 e-mail: info@hte-company. de

hte staff