We dedicate

our heart and passion

into medical care

In 1984, we successfully developed and commercialized the world’s "rst piston-type HFO (High

Frequency Oscillation) mechanical ventilator. It was clinically evident that HFO ventilation would

be superior to conventional methods, but the commercialization of HFO had always been considered

extremely di#cult. At the time, we said to ourselves, “if we can turn this into a reality, we can save so

many premature newborn lives that no others can save today” – this aspiration drove us to take this

di#cult technological challenge where nobody else had succeeded. $rough repeated trial and error,

we "nally completed our "rst product. We took this product to be evaluated for use in the world’s "rst

large-scale clinical trial for HFO ventilation, called the “HiFi Trial” sponsored by the NIH (the United

States National Institute of Health), and was chosen as the preferred HFO ventilator over numerous

other ventilators submitted by various manufacturers throughout the world. Since then, our HFO

ventilators have been steadily evolving through our successive research and development e%orts.

We are enormously proud that our HFO ventilators have been installed and used in more than 90%

of Japan’s NICUs (neonatal intensive care units) and contributes to Japanese premature neonatal care

that is considered to be the world’s best. As a critical-care medical device developer and manufacturer,

we have absolute conviction in ourselves – our job is not to force patients to adapt to our technologies,

but we must rather advance our technologies so that our products will coincide with what patients

and their conditions require. It is our strong belief that the developer’ s “heart” and “passion” can only

make such an ideal a reality. With this in mind, we will continue our challenging journey.

Our Mission

“We want to save lives” - This has always been our greatest motivation

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Our Mission

Group Chairman, Metran Co., Ltd. Kazufuku Nitta ( Tran Ngoc Phuc )

Our Vision

From state-of-the-art critical-care medical devices to home healthcare

and veterinary support, we will continue to support patients waiting

for Metran’s “one of a kind” medical devices

Our desire is to develop products that can help people rejoice in human life,

no matter what their medical condition

It is an unfortunate fact that there are still many premature newborns in the world that pass away

beyond help. "ere are also many patients who are having a di#cult time just breathing at home every

day. As well, there are countless people who are forced into uncomfortable and sometimes unbearable

treatment while su$ering from Sleep Apnea Syndrome. As we visit the front lines of various clinical

scenes, we keenly feel that there are many various issues that need to be addressed for patients in an

expeditious manner. In order for people to spend their lives in a comfortable and digni%ed manner,

and for regaining healthy daily living, we have devoted ourselves to medical technology development

that only we are capable of. From state-of-the-art critical care devices for the ICU, to homecare and

veterinary support, it is our determination to spread our development expertise and products

throughout the world to improve the quality of life of patients everywhere.

Metran possesses many inventive and innovative technical and development capabilities that allowed

us to be the world’s %rst, and still Japan’s only, HFO ventilator manufacturer. We also possess an

abundance of clinical and technological know-how that has been fostered through collaborative

research in advanced medical %elds. Most of all, we are a group of engineers who have a high level of

“passion” that is vital to support clinicians who face di#cult medical scenarios every day. We believe

that because of these reasons, we have earned the respect and credibility of a great number of

clinicians as well as various collaborative partners. We are dedicated to further advancing our product

development and manufacturing capabilities, as well as expanding our business activity throughout

the world. We look forward to working with our partners in collaborative development e$orts, and

will continue to give our utmost devotion to developing and producing the world’s best products.

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Our Vision

President, Metran Co., Ltd. Shinichi Nakane

Our Technology

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Our Technology

We possess the technological development capabilities that allowed us to

successfully develop and commercialize the world’s only piston-type HFO ventilator

Although there are di"erent types of HFO ventilators available today, the piston-type oscillator is

considered the most gentle and the safest approach to manage the respiratory needs of challenging

patient scenarios, especially to treat the lungs of premature newborns. Metran is the only company

in the world that has successfully realized the piston-type HFO ventilator. Accurate and stable

control of the piston movement at the micron level allows our ventilators to cope with a variety of

di#cult clinical cases very precisely, even at the 900 oscillations per minute.

As typified by our Hummax System, we possess the hardware development

capabilities that uniquely maximize patients’ comfort

$e Hummax system, with a hydrophobic %ber membrane inside the breathing circuit, allows control of

temperature and humidity of inhaled gas. $is membrane acts similar to the human mucous

membrane, reducing the discomfort associated with the use of mechanical respiratory devices.

Metran’s goal is to advance our development of devices that truly take account of patients’ comfort.

The software development capabilities that best optimize algorithms and

other important elements of device software

From state-of-the-art advanced medical treatment devices to home healthcare, so&ware is the essential

element for precisely controlling each medical device. $erefore, so&ware development should achieve

the proper and precise control allowing accurate reaction in case of rapidly rising or decreasing patient

demands. Metran’s devices are equipped with proprietary so&ware developed in-house, o"ering precise,

reliable and safe control of the devices in various challenging cases.

With a fusion of expert hardware and so"ware engineering,

we have opened up the future of mechanical ventilation

Our Research & Development

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Our Research & Development

Exceptional communication and interaction is critically essential in

research and development

We are constantly striving to increase our knowledge by studying and learning leading edge research, by

reading clinical papers and publications as well as participating in global medical standards meetings

and clinical conferences. Moreover, through our close communication and interaction with clinicians

who are playing a critical role in the front line of clinical practice, we are able to continually gather the

important information that will assist in our research and development e"orts. In some instances, we

have the privilege of participating in clinical situations through our various collaborative research

activities with teaching and research hospitals. We make all these e"orts with the goal of developing

ideal medical devices based on the real-world needs of the clinical theater. #is has been at the heart of

Metran since our founding, and will continue to drive our research and development e"orts in the future.

We will develop products that respond to the needs of

leading-edge medical practice

It is the clinicians in the medical front-line that provide us with the needs for medical devices in the

most realistic and compelling way. #ose needs range from a device’s features to reliability and safety

factors, to a device’s visibility and usability to ideas that could relieve a patient’s burden. We, from our

engineers in the R&D team to our customer support and manufacturing teams, all listen to and

understand each and every voice. #is is possible because each of our employees gathers information

and needs within and outside our organization, and collectively shares the “intelligence” on a constant

basis. Also in today’s world, multi-purpose systemization but also simpli$cation of medical devices is

required. We see this as a new challenge to minimize the complexity of the ICU while providing all the

information necessary for good care. With the help of our domestic and international collaboration

partners, we will embark on this new challenge by using engineering expertise wherever it can be found.

In an e"ort to provide the highest level of technological development

that is expected at the leading edge of medical practice

#e premature infant (weighing 350 grams at

birth) in the photo su"ered from undeveloped

pulmonary function. #is infant was safely

saved without damage to the lungs through

the use of a Metran High Frequency

Oscillation (HFO) ventilator.

Our Products

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Our Products

Humming Vue

A state-of-the-art piston-type HFO ventilator that brings together over 30

years worth of technological achievements. "e Humming Vue provides not

only HFO mode but also all popular conventional and spontaneous

ventilation modes in order to e#ectively and swi$ly support a wide range of

patient conditions as well as enhancing speedy recovery of patients all with a

single device.

KM-X 3L( Oxygen concentrator )

Homecare oxygen therapy

supportive device. Battery-powered,

compact, lightweight and extremely

quiet. Our Oxygen Concentrator

can be carried in the front passenger

seat of a vehicle or in a special

carrying cart.

JPAP ( Continuous Positive Airway Pressure Unit )

Metran’s experience with CPAP devices to support SAS treatment is rooted in

a large number of entrusted contract development e#orts. Taking advantage

of our development experiences and know-how, “JPAP” was born as Metran’s

original product. JPAP, from its functionality and speci%cations to the device

construction, has been designed and best-optimized not only for treatment at

home but also for treatment during long-distance travel.

Hummax QE

"e world’s %rst humidi%er built right into the breathing circuit, Hummax QE

o#ers usage compatibility with Metran’s own or other manufacturers’ CPAP

devices. It brings the bene%ts of the Hummax System to prevent drying of the

mucous membranes by providing an ideal amount of humidi%cation for

non-invasive applications.

Compos X ( Veterinary Mechanical Ventilator )

A versatile ventilator that can be

used for many animal patients, from

a mouse to a horse. Compos X

allows veterinarians to manage

ventilation needs in a very safe way.

Our ventilator is already widely

used in veterinary hospitals both in

Japan and overseas.

From the hospital ICU to home healthcare settings,

Metran’s products are playing a critical role in various clinical scenes

CorporateProfile

METRAN CO., LTD.

2-12-18 Kawaguchi, Kawaguchi-shi, Saitama 332-0015 Japan

July 14, 1984

¥87.5 million

R&D, manufacture, sales, export and import of medical equipment, especially

arti"cial ventilators, anesthesia devices, respiratory monitors and veterinary

products.

38

Nihon Kohden Corporation (Critical care products)

Koike Medical Co., Ltd. (Home Healthcare)

#e University of Tokyo Hospital, Kyoto University Hospital,

National Center for Child Health and Development, Saitama Children's Medical

Center, Osaka University Hospital, other national university a$liate hospitals,

other general hospitals, veterinary hospitals, veterinary medical facilities, etc.

ME TRAN Co., Ltd. (Ho Chi Minh City, Viet Nam)

Metran Vietnam Co., Ltd. (Ho Chi Minh City, Viet Nam)

Metran VITEC (Binh Duong, Viet Nam)

Biotran Inc. (San Diego, California, USA)

Saitama Resona Bank Limited

#e Bank of Tokyo-Mitsubishi UFJ, Ltd

Shoko Chukin Bank

Tran Ngoc Phuc, Chairman

Shinichi Nakane, President

Dan Nitta, Vice President

Mitsuko Nitta, Director

Kazunori Kato, Auditing O$cer

Organization Name:

Headquarter:

Established:

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Principle of Business:

Employees:

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Corporate Philosophy

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Corporate Philosophy & Profile

Our goal is to develop “thoughtful” medical devices

Our “heart” is to listen and respond to the needs and requests of clinicians,

making sure that our products are truly good and comfortable for patients, and be absolutely safe and reliable.

Our goal is to develop and provide “One-and-Only” technologies and products

We continually strive to provide medical devices that are possible only by Metran.

We at Metran are all partners sharing the same aspiration

We, as Metran employees, together strive to meet the needs and expectation of healthcare market,

and serve a meaningful purpose to patients.

[ Metran Co., Ltd. ] founded as a manufacturer of medical equipment. Development of the

"Hummingbird" High Frequency Oscillation (HFO) arti#cial ventilator begins.

"Hummingbird" enters a competition sponsored by the National Institutes of Health (NIH) for HFO

ventilators in the U.S., winning #rst prize among ventilators from 8 di$erent manufacturers around the

world. Metran receives an order for 85 "Hummingbird" ventilators to be used in the #rst clinical trial of

its kind in the world. Development and manufacturing begins on the SAV-6 arti#cial ventilator for

veterinary use.

Development begins on the next generation anesthesia system "FOUNT-2000". %is system allows for

complete gathering and management of operating room data from one device. Development and

manufacturing begins on the "Compos β" ventilation and anesthesia system.

Development of the portable arti#cial ventilator "Popy" begins. Development and manufacturing begins on

a new system for carbon dioxide rejection for anesthesia use. Exporting of arti#cial ventilators begins.

Development of a new model of IMV ventilator "CV-5000" begins. With a new control mechanism, this

ventilator reduced patient breathing e$ort for better comfort. Development and manufacturing begins on

the "Humming II" High Frequency Oscillator arti#cial ventilator. %e "Humming II" was the successor to

the "Hummingbird" arti#cial ventilator and o$ered IMV ventilation functionality as well as HFO.

Development and manufacturing begins on a new IMV arti#cial ventilator for use with infants and

premature newborns.

Development begins on the "Rotary HFO" device to support the next generation of High Frequency

Oscillation ventilators

Development and manufacture of the "Humming V" High Frequency Oscillation arti#cial ventilator.

%e "Humming V" was a high-power and high-functionality successor to the successful "Humming II"

ventilator.

Development begins on the "PB-920" arti#cial ventilator for use with infants and premature newborns.

Development and manufacture of the NOx inhalation system begins. Development began on a new

breathing airway circuit with a built-in humidi#cation system.

Development begins on a new model of IMV arti#cial ventilator for use with infants and premature

newborns. Development, manufacture and sales are planned for a new model arti#cial ventilator with NSV

breathing method.

Awarded development funding on new ventilation system (NSV) by VEC (Venture Enterprise Center)

Development begins on the innovative heating/humidifying system "Hummax" series.

Development and manufacture of infant-use "Calliope” and adult-use "Eliciae” arti#cial ventilators begins.

Development and manufacture of "Calliope α" and "M7α" arti#cial ventilators for infant use begins.

Development and manufacture of "M6 α" arti#cial ventilator for adult use begins.

Development and manufacture of the adult-use R100 arti#cial ventilator begins.

Obtains ISO 9001 (2000) certi#cation and ISO 13485 (2003) Certi#cation.

Established the group a*liate "Biotran Inc." in San Diego, California, U.S.A.

Begins international marketing of Biotran's #nger-type pulse oximeter "FOX". Development and

manufacture of CPAP unit “Jusmine” begins for an OEM supply to Koike Medical Co., Ltd. Development

and manufacture of infant-use "Humming X” arti#cial ventilator begins.

Agreed on the exclusive distribution rights in veterinary and lab research markets with Hamilton %orne

Biosciences Inc. in U.S.A. Represented product line was “Xyclone” laser abrasion system.

Establishment of Vietnam Factory Me Tran Co., Ltd. (Ho Chi Minh City). Development and manufacture

begins on the portable Oxygen Concentrator “KM-X” for homecare oxygen therapy for OEM supply to

Koike Medical Co., Ltd.

Acquired CE mark for Rotary HFO/IMV ventilator for infant and adult “R100” arti#cial ventilator.

Development and manufacture on Oxygen concentrator KM-X3L begins for an OEM supply to Koike

Medical Co. Ltd. Entered an agreement with Nihon Kohden Corporation for comprehensive business

alliance and global distribution arrangement of Metran’s critical care products.

ME TRAN Co., Ltd. received ISO9001 (2008) certi#cation and ISO13485 (2012) certi#cation.

Development and manufacture of veterinary ventilator “Compos X” begins.

Received CMDCAS approval for sales of ventilators in Canada.

His Imperial Majesty the Emperor of Japan made an honorable visit to the Metran factory.

Metran and Fukuda Denshi Co., Ltd. establishes the joint venture company “Breath Technology Inc.” to

develop new home-heathcare devices. %e second factory in Vietnam, Metran VITEC, was established.

Metran Vitec receives ISO 9001 (2008) and ISO 13485 (2012) approval. %e founder of Metran, Tran Ngoc

Phuc, becomes chairman of the group companies and Shinichi Nakane is promoted to President and

Representative Director of Metran.

Domestic marketing of next generation High Frequency Oscillatory Ventilator “Humming Vue” begins.

1984

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2014

2015

CompanyHistory

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Company History

Group Affiliate

ME TRAN CO., LTD. (VIETNAM)

37-37A Dong Ho, Phuong 8, Quan Tan Binh, Ho Chi Minh City, Viet Nam

Tel: (84) 8-3864-0528 Fax: (84) 8-3864-0622

July 9th, 2008

800,000,000VND

Dan Nitta

Manufacture and sales of medical devices and equipment

Vietcom Bank

METRAN VIETNAM CO., LTD. (VIETNAM)

37-37A Dong Ho, Phuong 8, Quan Tan Binh, Ho Chi Minh City, Viet Nam

Tel: (84) 8-3864-0528 (84) 8-3971-2552 Fax: (84) 8-3864-0622

August 28, 2007

US$100,000

Hoang Khoi Ngoc

So"ware and electrical hardware development

METRAN VITEC CO., LTD. (VIETNAM)

Lo K-5B-CN, Khu Cong Nghiep My Phuoc 2, #i xa Ben Cat, Tinh Binh Duong, Viet Nam

Tel: (84) 650-3557822 Fax: (84) 650-3557820

December 26, 2012

US$100,000

Dan Nitta

Manufacture and export of medical equipment, medical devices, and

sterile water for medical devices.

#e Bank of Tokyo-Mitsubishi UFJ Ltd., Vietcom Bank

Bangkok Bank Public Company Ltd.

BIOTRAN, INC. (U.S.A.)

11515 Escoba Pl, San Diego, CA U.S.A.

Tel: (1) 858-863-0621

January, 2004

US$10,000

Shon Nakanishi

Development of strategic alliances with partner companies.

International business development and veterinary product distribution.

Union Bank of California

Organization Name:

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CEO & President:

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Organization Name:

Headquarter:

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CEO & President:

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Organization Name:

Headquarter:

Established:

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President:

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Main Bank:

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Group Affiliate