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Research Article: New Research | Neuronal Excitability

Hetereogeneity in Neuronal Intrinsic Properties: A Possible Mechanism for Hub-like Properties of the Rat Anterior Cingulate Cortex during Network Activity

Fast network oscillations in the ACC

Natalie E. Adams1,2,*, Jason Sherfey2,3,*, Nancy J. Kopell2, Miles A. Whittington4 and Fiona E.N. LeBeau1

1Institute of Neuroscience, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne,NE2 4HH, UK2Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, MA 02215, USA3Center for Computational Neuroscience and Neural Technology, Boston University, 111 Cummington Street,Boston, MA 02215, USA4F1- Department of Biology, Hull York Medical School, York University, Heslington, YO10 5DD, UK

DOI: 10.1523/ENEURO.0313-16.2017

Received: 17 October 2016

Revised: 6 January 2017

Accepted: 14 January 2017

Published: 7 February 2017

Author contributions: N.A. and J.S. performed research; N.A. and J.S. analyzed data; J.S. and F.E.L.designed research; N.K., M.W., and F.E.L. wrote the paper.

Funding: NSFDMS-1042134

Funding: Wellcome100010269WT098352AIA

Funding: AROW911NF-12-R-0012-02

Conflict of Interest: Authors report no conflict of interest.

DMS-1042134 (PI: Kopell) NSF Cognitive Rhythms Collaborative: A Discovery Network. W911NF-14-1-0374. PI:Nancy Kopell. ARMY RESEARCH OFFICE. Wellcome Trust WT098352AIA to M.A. Whittington.

*N.E.A. and J.S. contributed equally to the work.

Corresponding author: F.E.N. LeBeau, Institute of Neuroscience, Newcastle University, MedicalSchool, Framlington Place, NE2 4HH, UK. Tel. 44-191-208-5729; Fax: 44-191-208-5227. E-mail:fiona.lebeau@newcastle.ac.Uk

Cite as: eNeuro 2017; 10.1523/ENEURO.0313-16.2017

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in vitro

in vitro

in vitro

Slice Preparation and solutions

∼

μ

°

Recording Techniques

Data Analysis

Post-synaptic potentials

ACC cell intrinsic properties

Cell Clustering

Statistical Analysis

Computational Modelling

Pyramidal cell model

t

in vitro

in vitro

in vitro

Biophysical network model

in vitro

Model analysis

Analysis of model networks with one assembly

Analysis of model networks with two assemblies

t

Kainate-evoked network oscillations in ACC.

Local network inhibition

ACC intrinsic cell properties

Biophysical diversity reproduces IP diversity in computational cell models

Beta and gamma frequency rhythms were generated by different inhibitory decay

constants in an ACC network model

Network heterogeneity decreases competition and increases synchrony among

multiple assemblies

Local generation of gamma and beta oscillations

in vitro in

vitro

Variability of oscillatory inputs to ACC

Intrinsic electrophysiological properties of neurons in ACC

in

vitro

Consequences for ACC functionality in a dynamic network

Conclusions

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μ

Adams et al Figure 1

Adams et al Figure 2

Adams et al Figure 3

Adams et al Figure 4

Adams et al Figure 5

Adams et al Figure 6