65
Herbal Approach to the Treatment of Lyme Disease Dr. Emily Maiella 432 Greenfield Rd Montague, MA 413.367.9350

Herbal Approach to the Treatment of Lyme Disease

  • Upload
    brinly

  • View
    50

  • Download
    2

Embed Size (px)

DESCRIPTION

Herbal Approach to the Treatment of Lyme Disease. Dr. Emily Maiella 432 Greenfield Rd Montague, MA 413.367.9350. The treatment of Lyme has changed. - PowerPoint PPT Presentation

Citation preview

Page 1: Herbal Approach to the Treatment of Lyme Disease

Herbal Approach to theTreatment of Lyme

DiseaseDr. Emily Maiella

432 Greenfield RdMontague, MA413.367.9350

Page 2: Herbal Approach to the Treatment of Lyme Disease

The treatment ofLyme has changed

• In 2006 I began going to ILADS conferences. The attendance was not big, usually in just an auditorium. There was never any presentations regarding natural medicines and the treatment of Lyme.

• This year, I attending my 7th ILADS conference. Not only was the conference enormous, reaching maximum capacity in at least 4 big conference rooms, but there was an entire “track” dedicated alternative medicine. The treatment of Lyme has shifted.

Page 3: Herbal Approach to the Treatment of Lyme Disease

• Alternative treatments are more cumbersome, but it is more joyful when you get there and more congruent in keeping with the needs of the earth.

Page 4: Herbal Approach to the Treatment of Lyme Disease

ListenLyme disease is a highly variable and adaptive organism.

There is no one treatment that will work for all patients. Every incidence is unique and the practitioner must see the person in front of them.

Patients need individual attention so they can tell their entire story from the beginning. There is information in these stories that help to guide where the treatment begin.

What was your life like before this illness? “The response of the host makes the disease”. It is often not the bugs that create the symptoms, but our immune systems response to them is far more relevant.

Page 5: Herbal Approach to the Treatment of Lyme Disease

Evolution with Peaceful Intentions

Treatment should always keep in mind that our immune-system is in a never- ending training and adaptation program. We are evolving. The same is true for the microbes.

I truly believe that you can’t heal when fearful. I’m here to help counter the dooms-day reports

My hope is that we can seek a peaceful inner state - in which microbes are welcome as long as they contribute to the greater whole. It is difficult to understand Lyme disease in this way, but my hope is that our unconscious and our immune-system does/can.

Plant adaptogens have a great potential in helping us in this necessary process of evolution.

Page 6: Herbal Approach to the Treatment of Lyme Disease

We are Super Organisms!• The evolutionary process has made become

a symbiote which contains over 3.3 pounds of microbial mass in our gut, with over 10 trillion cells that continuously interact with and modify our genetic phenotype.

• The number of bacteria living within the body of the average healthy adult human are estimated to outnumber human cells, 10 to1.

Page 7: Herbal Approach to the Treatment of Lyme Disease

We live in their world….• 90% of us is bacterial DNA• 10% of us is our own DNA

Parasite elimination prior to Lyme treatment is important. (ie lung worm for chronic fatigue patients)

Page 8: Herbal Approach to the Treatment of Lyme Disease

Layered Treatment modelThe treatment of Lyme and co-infections is a layered

process, because as a patient moves through treatment, it is not uncommon for the symptom picture and pathology to change.

• Outer layer: What the immune system is currently challenged with.

• Second Layer: The next dominant pathogen/pathology that will manifest in a change in the symptomatic pattern

• Third Layer: Weaker pathogen which will come forward next with a set on milder symptoms.

• Innermost Layer: Deepest layer that is probably related to your genetic susceptibility.

Page 9: Herbal Approach to the Treatment of Lyme Disease

Foundation HealthThere are some foundational aspects of health

that I make sure that are addressed during (or even before) treatment.

~sleep~inflammation~hormones (thyroid, adrenal, insulin and sex

hormones)~toxic exposures (metals, EMF’s, mold), including

emotional/spiritual (ongoing and past)~diet~immune system imbalance

Page 10: Herbal Approach to the Treatment of Lyme Disease

Hierarchy of Treatment

• 1) Correct basic physiological parameters (pH, electrolytes, HPU/KPU, constipation, hormones)

• 2) Immune Modulation (which accounts for most of the symptoms)

• 3) Detox of biotoxins and exogenic toxins• 4) Decreasing microbial and parasitic burden.

Note that the last step is killing the microbes.

Page 11: Herbal Approach to the Treatment of Lyme Disease

INFLAMMATION• Borellia uses specific mechanisms, primarily

inflammation, to breakdown the collagen tissues.• It is where this breakdown occurs that determines

where the symptoms emerge. If it is in the joints, arthritis presents. In the meningies, neurological Lyme is seen. In the heart, Lyme carditis presents. 

• Cytokines are inflammation chemicals made by the immune system in chronic diseases. They cause most of the symptoms. At the beginning of treatment when killing lyme spirochetes with antimicrobials (or yeast with antifungals), cytokines are made in even greater amounts, causing a person to feel much worse. Curcumin/tumeric, bromelain, boswellia, ginger and querectin are some great anti-inflammatories.

Page 12: Herbal Approach to the Treatment of Lyme Disease

SLEEP• Often disturbed in chronic Lyme disease. Lack of

adequate sleep worsens pain, increases fatigue, and suppresses the immune system.

• It appears that in response to infection, the excess inflammatory cytokines produced by the immune system decrease the output of sleep inducing hormones (melatonin) to the sleep centers of the brain. Sleep in the few hours before midnight is most restorative. There are many options here.

• Melatonin very useful due to it’s wide range of therapuetic benefits http://www.lef.org/magazine/mag2008/aug2008_Beyond-Sleep-New-Medical-Applications-for-Melatonin_01.htm

Page 13: Herbal Approach to the Treatment of Lyme Disease

HormonesLow hormones occur often in chronic Lyme disease.

Again, cytokines, decrease the effective functioning of the hypothalamus, pineal and pituitary glands (in your brain). These parts of the brain produce chemicals that induce sleep and that regulate hormonal systems.

Normally this part of the brain releases messengers such as thyroid stimulating hormone (TSH), adrenocorticotropin hormone (ACTH), and follicle stimulating hormone (FSH) to stimulate the thyroid, adrenal glands, and sex hormone organs, respectively.

Page 14: Herbal Approach to the Treatment of Lyme Disease

Hormones Cont.• A better way to check hormone status is to measure the

actual hormone levels like T4/T3 (thyroid), or cortisol/dhea (adrenals), or estrogen/progesterone/testosterone (sex hormones).

• However, these tests give a broad range of normal, therefore a person could have normal range testing for each of the hormones but still have clinically low hormones. Because of the unreliability of testing, treatment for low hormones should occur if there are clinical symptoms of low hormones as long as treatment does not increase hormone levels above the upper end of normal.

Page 15: Herbal Approach to the Treatment of Lyme Disease

Adrenals and ThyroidAdrenal Insufficiency: rule this out if you have fatigue,

recurrent infections, poor recovery from infections, low blood sugar with shakiness and irritability relieved by eating, low blood pressure and dizziness on standing, afternoon crashing, and sugar cravings. Natural medicines include: Ashwagandha, schizandra, licorice, rhodiola

Prolonged antibiotic therapy will deplete the adrenals.

Low Thyroid: fatigue, achiness, low body temperatures, cold intolerance, weight gain, constipation, changes in menstrual periods. Can be confused with adrenal insufficiency. Natural medicines: Lots of different options here, just be aware of iodine content as too much can make thyroid conditions worse.  

Page 16: Herbal Approach to the Treatment of Lyme Disease

Auto-immune imbalancesT cells and B cells from some patients with

chronic Lyme disease are reactive not only against Borrelia burgdorferi-specific antigens but also against various host (self) antigens. This mimicry might generate autoimmune inflammatory reactions that could be responsible for arthritic as well as some neurological symptoms associated with chronic Lyme disease.

This happens with people that have specific HLA genotypes (HLA-DR4 and 2)

Page 17: Herbal Approach to the Treatment of Lyme Disease

Diet and Lifestyle choices• This is going to be one of the most challenging journey that you

will embark on. There is a lot to be done on your part while the medicines do their job. My treatment plan includes dietary changes with emphasis on nutrient dense foods such as seeds, nuts, free range eggs, balanced 4:1 omega 6 to omega 3 oil, organic protein foods, and green leafy vegetables. I usually recommend all grain/flour, sugar, processed foods, and hydrogenated fats to be removed. Building a strong nutritional foundation is paramount and is accomplished by raising the mineral base, stabilizing the electrolytes, increasing and balancing essential fatty acids.

• Minimizing aggravating factors: This is my toxic 50 gallon barrel analogy. What have you put into your barrel over your life? Time to get rid of it. Think toxic homes, toxic relationships, heavy metal overload, gut dysbiosis, yeast over growth and food allergies (to think of a few). A food allergy test and a stool microbiology test is recommended prior to starting treatment

Page 18: Herbal Approach to the Treatment of Lyme Disease

Herbal protocolMany options and protocols available. I tend to use Uncaria,

Andrographis, Smilax, Polygonum, Teasel, Stephania garlic and Guacucium. Dosage is highly variable. Some patients need a few drops while others require tablespoons. It is difficult for the spirochetes to develop immunity to this type of an herbal regimen due to the complex phytochemicals of the herbs.

Herbs have the ability to address many aspects of dysfunction:~They are anti-inflammatory which help to stop the breaking

down of collagen. ~They support the formation and strength of collagen in the body. ~They allow the doctor to design specific treatment interventions

for the unique symptom picture of the patient. ~Immune system modulators to correct immune dysfunction.~ Anti-spirochetals to control infection. The use of anti-

spirochetals continues to get lower and lower on the list as time has gone on. 

Page 19: Herbal Approach to the Treatment of Lyme Disease

Polygonum cuspidatum

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

Page 20: Herbal Approach to the Treatment of Lyme Disease

Japanese KnotweedAn invasive botanical in almost

every place where Lyme has emerged. Nature has a way of helping.

Japanese Knotweed shuts down the inflammatory pathways initiated by the spirochetes. It inhibits lipoxygenase, prostaglandin E and NF kB, which are all up-regulated in Lyme disease.

Page 21: Herbal Approach to the Treatment of Lyme Disease

Japanese knotweed• Knotweed crosses the blood brain barrier. It is

specific for inflammation in the meninges (stiff neck and headaches)

• It is a potent antioxidant and has protective effects on the brain. It calms the central nervous system and helps with arthritis symptoms in Lyme disease.

• Knotweed is an herb and drug synergist meaning that when it is used with antibiotics, it makes them powerfully effective even in cases where they previously failed. Take Japanese Knotweed along with antibiotic therapy.

Page 22: Herbal Approach to the Treatment of Lyme Disease

Japanese knotweed• It modulates the immune system by either raising or

lowering immune function as required in each unique person (immune modulating), thereby reducing the dynamics involved in autoimmunity.

• It is an angiogenesis modulator and controls the healthy generation of blood vessels. It stimulates microcirculation to the eyes (due to it’s High content of resveratrol) and joints thus helping to facilitate the movement of drugs or herbs to those locations.

• It is cardioprotective and helps to remove endotoxins, which is a benefit to those with Herxheimer reactions during treatment. 

Page 23: Herbal Approach to the Treatment of Lyme Disease

Japanese knotweed

• Traditional Chinese Medicine has used it as a blood-moving herb, to resolve inflammation, stagnation, and poor circulation, but also as a supportive herb, to counter debility and immune fatigue. Because it is considered to be an herb that slows down the aging process (together with its relative Polygonum multiflorum, also known as Fo Ti and Shou Wu), millions of Chinese use Japanese knotweed to prolong youth.

Page 24: Herbal Approach to the Treatment of Lyme Disease

Japanese knotweed

• Similar to astragalus, it has an adaptogenic or immune-balancing quality, which makes this an effective ally in balancing the body’s immune responses; it can stimulate immune cells, as in Lyme disease, or modulate them, as in an autoimmune disease. By supporting the blood flow to difficult-to-reach regions of the body, Japanese knotweedʼs antimicrobial and anti-inflammatory actions can reach the eyes, joints, and brain.

Page 25: Herbal Approach to the Treatment of Lyme Disease

Other published functions of knotweed

• Peer review literature (pubMed): Many gram neg and gram pos bacteria, Anti-viral, Hepatitis B and C, many types of cancer (esp hepatocelluar cancer), cardiovascular disease, anti-inflammatory.

• Other published positive effects: antimicrobial, protects against microbial endotoxins, Lowers cholesterol and lipids, Increases wound healing, Ischemic heart disease, Leukemia, Stimulates fibroblasts (proliferative effect), Rheumatoid arthritis, Psoriasis, Increases bone mass, Reduces auto-immunity, Strongly neuroprotective (ALS, Alzheimer, Parkinson’s, MS, cerebral ischemia).

Page 26: Herbal Approach to the Treatment of Lyme Disease

Dosage for knotweed:• Whole herb (Aka the root) (Hu Zhang)

standardized to 8% total resveratrol and 10 mg resveratrol. 500 mg tablet.

• Use 3-4 caps 3-4 times/day. Work up slowly to this dose

• Contraindications: Pregnancy, Consider carefully when giving with blood thinners (synergistic effect), may cause a metallic or odd taste in the mouth. 

Page 27: Herbal Approach to the Treatment of Lyme Disease

andrographis paniculata• King of Bitters

QuickTime™ and a decompressor

are needed to see this picture.

Page 28: Herbal Approach to the Treatment of Lyme Disease

Andrographis paniculata

• Andrographis has been used traditionally in China to treat all manners of febrile diseases and infections. It is used throughout China and India for its apparent anti-parasitic and antimicrobial actions to treat syphilis, malaria, and worms; and for swollen lymph glands with fever, abscesses, and lung and sinus infections. It was used in many cultures to treat syphilis until antibiotic drugs became more available.

Page 29: Herbal Approach to the Treatment of Lyme Disease

Andrographis paniculata

• Recent scientific research, has indicated that it has antimicrobial effects, it supports immune function, increases interleukin-2 production, and has some cancer-targeting actions. (Singha PK, Roy S, Dey S. Antimicrobial activity of Andrographis paniculata. Fitoterapia. 2003;74:692-694; Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol. 2004;92:291-295; Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol. 2003;3:147-158.)

Page 30: Herbal Approach to the Treatment of Lyme Disease

Andrographis paniculata

a simple pubmed search….1. kidney protective (rapid excretion via kidneys)

2. anti-spirochetal3. crosses blood brain barrier4. protects heart muscle, anti-inflammatory5. potent modulating effect on mast cell and

neutrophil activity: turns off inappropriate mast-cell allergic reactions in tissue

6. enhances liver function7. protective effects against inflammation-

mediated neurodegeneration of brain, spinal cord and CSF

Page 31: Herbal Approach to the Treatment of Lyme Disease

Andrographis paniculata8. Filarial diseases9. leptospirosis10. malaria (suggesting strong effect against

Babesia)11. periodontal bacteria (gum disease)12. AIDS13. cancers: prostate, breast, colon, anal,

stomach ,skin melanoma, leukemia 14. TB15. Tonsilitis, pheumonia, herpes, E. coli, snake

bites

Page 32: Herbal Approach to the Treatment of Lyme Disease

Andrographis paniculata• Dosage: 400 mg capsules standardized to 10%

andrographolides. Start with 1 cap 4 times/day. Slowly increase to 3 caps 4 times/day. Stay on this dose till Lyme sx significantly decreased, then slowly decrease dose.

• It needs to be taken at least three times a day as it moves out of the body rapidly.

• Stop during severe Herxheimer reactions. 1 year

• Contraindications: andrographis lowers progesterone (natural contraceptive), pregnancy, and acute gallbladder disease. The main side effect of andrographis is that 1% of the people that take it will get severe hives that takes as long as two months to resolve. Start with a lower dose to watch for s/e’s

Page 33: Herbal Approach to the Treatment of Lyme Disease

Smilax glabra• Roots: 6-8 feet long

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

Page 34: Herbal Approach to the Treatment of Lyme Disease

Smilax glabra, spp.• Sarsaparilla root has been used for

centuries by the indigenous peoples of Central and South America for sexual impotence, rheumatism, skin ailments, and as a general tonic for physical weakness.

Page 35: Herbal Approach to the Treatment of Lyme Disease

Smilax• Amazonian medicine folk use sarsaparilla

root internally and externally for leprosy and other skin problems (such as psoriasis and dermatitis.)

• Just FYI: Leprosy can be common in areas where the disease is carried by armadillos (and in the Amazon, armadillos are "on the menu" in indigenous diets).

Page 36: Herbal Approach to the Treatment of Lyme Disease

Smilax and Syphilis• European physicians from as early back as

1536, considered sarsaparilla root a tonic, blood purifier, diuretic, and sweat promoter, BUT mostly as an syphilis cure. Since this time, Smilax roots have had a long history of use for syphilis and other sexually-transmitted diseases throughout the world.

• It was registered as an official herb in the U.S. Pharmacopoeia as a syphilis treatment from 1820 to 1910.

Page 37: Herbal Approach to the Treatment of Lyme Disease

More uses of Smilax

• A U.S. patent was awarded in 2003 describing these flavonoids to be effective in treating autoimmune diseases and inflammatory reactions through their immunomodulating effects. Sarsasapogenin and smilagenin were subjects of a 2001 U.S. patent which reported that these Smilax steroids had the ability to treat senile dementia, cognitive dysfunction, and Alzheimer's disease.

Page 38: Herbal Approach to the Treatment of Lyme Disease

What is an endotoxin anyway?• Clinical research has validated the traditional

use of sarsaparilla for skin conditions such as psoriasis, eczema, acne, and leprosy. (NEJM).

• One of the possible mechanisms of action in psoriasis is sarsaparilla's blood cleansing properties. Pts. with psoriasis have been found to have high levels of endotoxins circulating in the bloodstream (endotoxins are cell wall fragments of bacteria). Sarsaponin, one of sarsaparilla's main steroids, was found to bind to these endotoxins and remove them, thus improving psoriasis.

Page 39: Herbal Approach to the Treatment of Lyme Disease

Smilax and the Herx reaction• As bacteria break down, they release endotoxins

that normally are cleansed from the gut by the lymphatic system and the liver. If the endotoxins are excessive and cannot be eliminated, the body experiences a toxic overload. This toxic overload triggers an inflammatory reaction as the body moves into a fight pattern, causing a flare-up of symptoms of arthritic pain, skin inflammation, and irritability. Sarsaparilla’s binds endotoxins in the intestines before they get into the bloodstream.

Page 40: Herbal Approach to the Treatment of Lyme Disease

Smilax glabra (Sarsaparilla)

(another pubmed search)

1. Leptospirosis2. Treponema pallidum (syphilis)3. liver flukes (clonorchis sinensis)4. shigella and salmonella5. Leprosy6. TB7. fungal skin infections

Page 41: Herbal Approach to the Treatment of Lyme Disease

Smilax glabraother published/clinical

evidence • Lyme endotoxin binding• Lessens Herxheimer reactions• Improvement in mental and psychological

parameters in chronic lyme and syphilis• Modulates immune responses esp w/ autoimmune

dysregulation • Arthritis (anti-inflammatory and pain relieving)• Psoriasis and eczema, Reduces skin breakdown• Neuroprotective (crosses blood brain barrier)• Improves liver function, including Hepatitis C• Lessens fatigue• Increases libido • Asthma, hay fever, rhinitis

Page 42: Herbal Approach to the Treatment of Lyme Disease

Smilax Glabra

• Dosage: 425-500 mg caps 1-3 caps 3-4 times/day. Increase slowly to full dosage, stay on it for 2 months, then slowly reduce to maintenance dose of 1 caps 3 times/day. At least 1 year

• Contraindications: Increases digitalis, digoxin (CHF and dysrhythmias ) and Bismuth absorption, increased elimination of hypnotic drugs.

Page 43: Herbal Approach to the Treatment of Lyme Disease

Uncaria tomentosa• Cat’s Claw; Amazonian vine. Make sure that only the

bark is harvested, as some companies harvest the root, and is therefore in danger of over harvesting.

QuickTime™ and a decompressorare needed to see this picture.QuickTime™ and a decompressorare needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

Page 44: Herbal Approach to the Treatment of Lyme Disease

Uncaria tomentosa

In lyme, it acts as a immune potentiator, which helps to raise CD57 white blood cell counts. Anti-inflammatory and analgesic, so useful for joint and muscle pain associated with Lyme.

Especially good for neuroborreliosis, chronic fatigue and cognitive decline.

Page 45: Herbal Approach to the Treatment of Lyme Disease

Cat’s claw

• The Ashaninka Indian priests in Peru used Catʼs claw to regulate disturbances between a personʼs body and spirit.

Page 46: Herbal Approach to the Treatment of Lyme Disease

Cat’s ClawTOA’s (Tetracyclic

oxindole alkaloids) or not?In some cases, people have experienced that they

cannot tolerate full-spectrum Cat's Claw, however, they can tolerate TOA-free. I have not found the studies on TOA-free to be very convincing. It is actually the TOA’s that help the central and peripheral nervous system. The POA’s (Pentacyclic oxindole alkaloids) which is another type of alkaloid in Cat’s Claw, helps with the immune modulation, so both are important. I generally suggest using full-spectrum Cat's Claw.

For a great discussion on the differences: http://www.rain-tree.com/toa-poa-article.htm#.UYf5-StATms

Page 47: Herbal Approach to the Treatment of Lyme Disease

Teasel: Pinyin name in is Xu Duan, “restore what is broken”

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.QuickTime™ and a decompressor

are needed to see this picture.

Page 48: Herbal Approach to the Treatment of Lyme Disease

Teasel-from an eclectic perspective

• When a plant has a prickly doctrine of signature (like eluethero, nettle and raspberry) they will help you to break something down and weave something new. Used to tease cloth, wool in particular (tapestry).

• Eclectic herbalist say that is will mend things that are broken, esp in energetic field. Adrenal pulses will change when using it.

Page 49: Herbal Approach to the Treatment of Lyme Disease

Teasel

• Lyme disease spirochetes attack and penetrate into collagen tissue, affecting the joints and tendons throughout the body, teasel root seems to fit right in. Rather than killing the bacteria, teasel helps to change the bodyʼs environment, so that the body itself can kill off the Lyme bacteria by bringing the bacteria into the bloodstream, where it can detoxify.

Page 50: Herbal Approach to the Treatment of Lyme Disease

Teasel: Traditional Chinese Medicine

• Yang tonifying herb, Dipsacus fortifies the lower back, knees and bones.

• It has a positive effect on the sinews and joints as well and is used for pain and stiffness from decreased Kidney energy or from traumatic injury.

• It is also used to promote the movement of blood and to repair damaged tissues.

Page 51: Herbal Approach to the Treatment of Lyme Disease

Teasel• Side of the road medicine, just like Lyme is a

side of the road disease• Only small amounts necessary. Begin with 1

drop, 3 times daily, and gradually increase the dosage to about 10 drops, 3 times daily.

• Can be taken internally as a tincture or decoction, applied topically in a salve or liniment, or one could address all aspects of the disharmony and choose internal and external treatment simultaneously.

Page 52: Herbal Approach to the Treatment of Lyme Disease

Stephania(Mountain Turtle)

• Parts used: rootlet or vine. The root which looks like a boulder and grows on top of the ground, which a vine grows from

QuickTime™ and a decompressor

are needed to see this picture.QuickTime™ and a

decompressorare needed to see this picture.

Page 53: Herbal Approach to the Treatment of Lyme Disease

Stephania S. tetrandra and S. cepharantha)

Lyme specific functions: ~Decreases inflammation in the CNS

(Bell’s palsy, uveitis, eyes)~Decreases inflammation in the joints~decreases fluid build up in tissues

and joints~helps to heal endothelium~Immunomodulation

Page 54: Herbal Approach to the Treatment of Lyme Disease

Stephania S. tetrandra and S. cepharantha)

Peer review literature/Science: effective against:1. Potent anti-inflammatory:

~Reduces the pro-inflammatory cytokines: IL-1 beta, IL-alpha, TNF-a, IL-6, IL-8 and COX-2 (especially in CNS and joints)~Reduces NF-kappa B and IL-6 during neuroborreliosis, ~Modulates HLA-DR expression

2. Treatment of silicosis (also breast implant immune complications)

3. Protects endothelium from endotoxin damage4. Reduces vascular permeability5. Bell’s palsy (decreased edema and vascular

extravasation AND by decreasing IL-6, IL-8 and TNF-a)

6. Free radical scavenger: Inhibits h202-induced neuronal cell death)

Page 55: Herbal Approach to the Treatment of Lyme Disease

Stephania7. Inhibits toxic glutamate levels in brain8. Ca-channel blocker: some studies show higher potency

than verapmil for the tx heart disease/hypertension)9. Retinopathy (modulates formation of new blood vessels and

improvement of vision, specifically for diabetic retinopathy)

10. Malaria (and Babesia)11. Inhibits cancer cell proliferation and multi-drug resistance

in cancer12. Anti-fibrotic/anti-scar formation13. Blocks abnormal histamine release/stabilizes mast cells

• Dosage: 1:5 tincture of both forms of Stephania, 1 tsp t.i.d.

Page 56: Herbal Approach to the Treatment of Lyme Disease

Stephania: why aren’t we using this?

• In Japan, there is a proprietary herbal formula called cepharnatha, which consists of the five main alkaloids in Stephania c.

• It’s widely available there, and is used for the tx of chronic inflammatory disease, radiation induced leukopenia, asthma and alopecia areata (all peer reviewed).

• Dosage: 1 tsp, 3 times per day. Do not use with AV block or severely hypotensive, or if taking Ca channel blocker, beta blocker or digoxin

Page 57: Herbal Approach to the Treatment of Lyme Disease

Artemesia annuaTraditional Chinese Medicine has used

sweet wormwood for over 2,000 years to treat fevers, inflammations, and bacterial infections, particularly malaria and other parasites. Artemisinin, a naturally occurring component of wormwood, is a potent antimalarial and is considered to be about 90% effective in curing uncomplicated malaria.

Page 58: Herbal Approach to the Treatment of Lyme Disease

Artemesia annua• However, in 2006, the World Health

Organizationʼs Global Malaria Programme issued an ultimatum to the pharmaceutical industry to phase out artemisinin as a monotherapy against malaria, because malaria parasites were becoming resistant to artemisinin as a single oral drug. WHO now recommends using artemisinin combination therapies (ACTs).

• (Rehwagen C. WHO ultimatum on artemisinin monotherapy is showing results. BMJ. 2006;332:1176.)

Page 59: Herbal Approach to the Treatment of Lyme Disease

Artemesia annuaDifferent protocols exist: Artemisinin:100 mg caps. 5 caps 3 times per day, 2

days in a row each week with grapefruit juice. 3 weeks on, 1 week off. 1 year needed for Babesia

OR:Artemisinin: 100 mg 3x/day for 30-40 daysOR Artemisinin (200-300 mg two times per day, 3 wk on,

1 wk off taken with grapefruit juice. This dosing has been shown in studies to be 20% more effective for malaria than the pharmaceutical treatments.

Source: Allergy Research For EBV: 2 caps Bid for months

Page 60: Herbal Approach to the Treatment of Lyme Disease

Klinghardt Lyme cocktail• 200-400 mg artemisinin, 100 mg glutathione, 10 ml phospholipids

exchange 9to make liposomal artemisinin (detox, anti-viral, anti-bab, anti-lyme, shuttle agent, biofilm breaker): Then add:

• D-galactose 95 grams), to increase ATP dramatically• 10-20 drops of 20% propolis tincture• Lyme herbs (Quitessence or from me), variable dosage• 15 ml Rechtsregulat (enzyme mix to break biofilms)• micro-silica 100 mg• co-curcumin (ayush herbs) 1 tsp plus pippli (2 caps)• vitamin c powder 2000 mg• acai powder (anti-microbial, anti-oxidant, 1 tsp• 1/2 glass grapefruit juice (important for artemisinin absorption)• 1/2 glass water

Page 61: Herbal Approach to the Treatment of Lyme Disease

KLINGHARDT LYME COCKTAIL cont….

• OPTIONAL:• Macuna powder 1 tsp to increase L-dopa

and neurotransmitter production• Grapefruit seed extract 10 drops• Freese died garlic 4 caps• Energized Neem: 2 caps 3 times/day

Page 62: Herbal Approach to the Treatment of Lyme Disease

Some over looked issuesThese overlooked issues can turn an asymptomatic

patient into an ill patient. 1. Parasites (the elephant in the living room)2. EMF exposure 3. Mold4. dental issues (amalgams, root canals, cavitations,

electrogalvanism, reactive materials)5. Viruses6. methylation blocks

Page 63: Herbal Approach to the Treatment of Lyme Disease

7. tonsillitis (ozone injections, cryotherapy)8. sinus infections such as MARCoNS (uses

Symbioflor nasally like a nasal probiotic)9. decreased regulatory peptides (such as MSH,

oxytocin, ADH, VIP, and melatonin). The first few are more causal and the last six are symptoms caused by the primary illness but they need to be fixed to address the overall condition.

Page 64: Herbal Approach to the Treatment of Lyme Disease

Thriiive.com"top"10"listHelpful life style choices for both parents and children. Thrive is a

think tank of experienced ASD and Lyme practitioners who believe that Autistic children have congenitally acquired Lyme from their Mother

1. Life: add pleasure,reduce stress2. Energy: add sunshine and nature, reduce EMF’s at night

3. Water: add purity and structure, reduce contaminants 4. Food: go organic and choose real food5. Exercise get moving: 30 min for you, more for the child

Page 65: Herbal Approach to the Treatment of Lyme Disease

6. Tests: utlilize more energetic testing, less blood draws/lab7. Emotions: decrease negative self talk, allow yourself to feel8. Body:treat and eliminate focal lesions (scars, dental, organs9. Supplements: add minerals, decrease multi vitamins (sensitize

towards food allergies), calcium (biofilm)10. Detoxify: open windows, no carpets, no shoes inside, wash

hands, no chemicals in home or garden, cups: no soap residues