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Delivering the Promise of Healthier LivesTM
AUGUST 2019
OTCQB: CURROTCQB: CURR
®
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Forward LookingStatements
To the extent any statements made in this presentation contains forward looking statements and information that are based upon beliefs of, and information currently available to, the company’s management as well as estimates and assumptions made by the company’s management. When used in this presentation the words “anticipate,” “believe,” “estimate,” “expect,” “future,” “intend,” “plan” or the negative of these terms and similar expressions as they relate to the company or the company’s management identify forward looking statements.
Such statements reflect the current view of the company with respect to future events and are subject to risks, uncertainties, assumptions and other factors relating to the company’s industry, its operations and results of operations and any businesses that may be acquired by the company. Should one or more of these risks or uncertainties materialize, or should the underlying assumptions prove incorrect, actual results may differ significantly from those anticipated, believed, estimated, expected, intended or planned. Although the company believes that the expectations reflected in the forward looking statements are reasonable, the company cannot guarantee future results, levels of activity, performance or achievements. Except as required by applicable law, including the securities laws of the United States, the company does not intend to update any of the forward-looking statements to conform these statements to actual results.
Our mission is to improve lives by redefining how medications are delivered and experienced.
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CUREPharmaceutical
We are an oral delivery company that develops and manufactures innovative formulations and dosage forms:
CUREform™
We improve absorption and
release of medicines and
supplements into the body
for easier, safer and more
effective administration.
We work with companies
with shared values to market
and distribute
pharmaceutical products and
dietary supplements.
What we do How we do it
© 2019 CURE Pharmaceutical
The Problem: Oral delivery is flawed
POOR BIOAVAILABILITYFor many molecules given orally, only a fraction of the
administered dose will make it to the blood due to poor
solubility or degradation in the GI tract and liver.
Almost 70% of Americans are on prescription medication.1
Oral drug delivery is the most preferred route of drug administration.
NON-ADHERENCEWhen drugs don’t work well enough and cause side effects, patients
stop taking them.
● 30-50% of Americans do not take medications as prescribed.2
● 40% of patients have trouble swallowing pills.3
SIDE EFFECTSWhen only a fraction of the administered dose reaches the
blood, more drug needs to be given which can cause GI irritation
and liver toxicities.
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CUREfilm®
dissolving film technologyCUREpods™
chewable pod technology
The Solution:
Our proprietary oral formulation and delivery platformCUREform™
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CUREform™
The RightDosage Form
The Right Formulation
Impacts the route of administration and metabolism
Improves solubility and
absorptionCUREfilm®
CUREpods™
CUREform™
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CUREfilm®The Right Dosage Form
Unique Attributes● Sublingual and buccal delivery options for direct
absorption into the bloodstream, avoiding first-pass
metabolism
● No need for water, swallowing or chewing
● Uniform drug distribution allows for precision dosing
Dose Loading● Multiple actives up to 200mg
● Stable at room temperature
Applications● Suitable for both pharmaceuticals and nutraceuticals
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CUREpods™The Right Dosage Form
Unique Attributes● Simultaneously load fat soluble and water soluble
molecules
● Controlled time, temperature and pH triggered
release of actives
● Overcomes problems with poorly soluble and
poorly absorbed nutrients
● Multiple shapes, sizes, flavors and colors
Dose Loading● High doses of actives (grams)
Applications● Ideal for nutraceuticals
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CUREform™The Right Formulation
PROTECTION FROM DEGRADATION during manufacturing,
throughout shelf life
and from stomach acids
INCREASED BIOAVAILABILITY
through greater water
solubility, enhanced
permeability and
retention in
target tissue
BETTER PALATABILITY
through improved
taste masking
SPECIFIC RELEASE PROFILES
(e.g. immediate or
controlled release)
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CUREformTM
Consumer Benefits
FAST SYMPTOM RELIEFRapid and/or sustained
delivery of active ingredients
NO PILLS TO SWALLOWIdeal for consumers that
cannot swallow pills PORTABLEDiscrete, lightweight and easy to transport
FEWER SIDE EFFECTSPotential to reduce the dose and avoid the GI tract
EASY TO TAKEPalatable with a pleasant mouth-feel and no water needed
© 2019 CURE Pharmaceutical
Strategic Approach
NUTRACEUTICALSTarget the growing wellness market
No FDA approval required
Faster and cheaper to launch than pharmaceutical medicines
CUREfilm® + CUREpods™
PHARMACEUTICALSNovel CUREfilm® drugs can be
approved via accelerated regulatory
paths such as 505(b)(2) and ANDAs with market exclusivity
CANNABINOIDSCUREfilm® + CUREpods™ cannabinoid products can be launched as nutraceuticals and pharmaceuticals
DEA Schedule 1 manufacturing license to formulate and manufacture cannabinoid drugs in-house
CUREform™ encapsulation to stabilize and improve the bioavailability of cannabinoids and terpenes
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● cGMP 25,000 sq ft production plant in Oxnard, CA
● FDA-registered and audited facility ● Clean room environment● Pharmaceuticals, dietary supplements and
controlled substances (DEA schedule 1 manufacturing license)
● Expansion capability● Custom drug delivery systems developed in
a design control process
Our Capabilities
PROCESSDEVELOPMENT AND SCALE UP
cGMP MANUFACTURING FACILITY
PRODUCT DEVELOPMENT AND CHARACTERIZATION
INTELLECTUALPROPERTY
13issued U.S. patents
11patents pending
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Revenue Streams
CONTRACT DEVELOPMENT AND MANUFACTURING
• Development fees• Manufacturing fees
IP LICENSING AND TECH TRANSFER
• License fees • Tech transfer fees
• Milestone payments• Royalties
IN HOUSE PRODUCT & CLINICAL DEVELOPMENT
• Upfront fees• Milestone payments
• Royalties• Manufacturing fees
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Formulation Development/
Preclinical
Manufacturing Scale Up
Launch
CUREfilm® BLUE (Sildenafil Pre-IND)
Nutraceutical Pharmaceutical
CUREfilm®/CUREpod™ Hemp
ClinicalDevelopment
CUREfilm® Sleep (two different sleep & recovery products)
ProductPipeline
CUREfilm® Canna (THC & CBD)
CUREfilm® D (weekly vitamin D3)
CUREfilm® β-Caryophyllene
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Market Opportunity
CUREfilm® Sleep
CUREfilm® Blue
CUREfilm® D
CUREfilm® β-Caryophyllene
CUREfilm®/CUREpod™ Hemp
CUREfilm® Canna
Global sales of melatonin supplements by 2024.4
Global CAGR by 2023.$2.1B 19.9% CAGR
Global sales of erectile dysfunction drugs by 2024.5
Global CAGR by 2018-2024.$7.1B 5.7% CAGR
Global sales of Vitamin D supplements by 2025.6
Global CAGR 2019-2025$1.7B 7% CAGR
Global sales of curcumin supplements by 2024.7
Global CAGR 2018-2024.$1.3B 12.3% CAGR
Global sales of cannabidiol (CBD) by 2022.8
Global CAGR 2017-2022.$1.9B 31% CAGR
Global sales medical cannabis by 2025.9
Global CAGR 2019-2025.$20.2B 24.4% CAGR
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● Formerly President and CEO of InnoZen Inc., CEO of Gel Tech LLC, CEO of Bio Delivery Technologies Inc.
● Lead the development of several drug delivery technologies and commercial brand extensions including Chloraseptic™, Suppress™, as well as Pediastrip™,
● B.S. degree in Biological Life Sciences; Masters Certificate in Applied Project Management , Master’s in Public Health, Masters in Wellness, Post Graduate Qualification at the University of Cambridge.
● Formerly Head of Innovation at Children’s Hospital Los Angeles, licensing officer at The Scripps Research Institute and held research, clinical and business development positions held at GlaxoSmithkline Biologicals.
● Founder and director of one of seven national FDA-funded pediatric medical device accelerators.
● Masters in Biochemical engineer at the Institut National des Sciences Appliquées in Lyon, France.
Jessica RoussetCOO
● Formerly CFO, vice president and general manager positions with several venture and private equity backed companies including Inogen, Medical Analysis Systems (acquired by Thermo Fisher Scientific), CDTi Advanced Materials, and Abrisa Technologies.
● Earlier experience includes management roles with Pepsi and in public accounting.
● CPA (inactive) with a B.S., Business Administration from California Polytechnic State University, San Luis Obispo.
MikeRedardCFO
Our Team: Officers
Robert DavidsonCEO
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● Over 35 years of experience leading technical teams.
● Leadership roles in process development at Amgen Thousand Oaks and Ireland
● Management positions at CancerVax, Certified Facilities, IDEC Pharmaceuticals, Xoma and Celtrix Pharmaceuticals.
● Trained as microbiologist and chemist at Brigham Young University.
● Formerly Project Leader with the Boston Consulting Group focused on corporate and network strategy, operations, marketing and post-merger integration initiatives.
● PhD in Immunology from the University of Pennsylvania; BSc. in Bio-Medical sciences from Tel-Aviv University in Israel.
Vered GigiVP, Strategy & Business Development
● Formerly Chief Accounting Officer and Controller at InnoZen, Inc.
● Auditing Manager at Green Hasson & Janks, LLP in Los Angeles. CPA and B.A. in Business Economics with a concentration in accounting from the University of California, Santa Barbara.
Mark UdellCAO
Our Team: Senior Leadership
Steven RuhlVP, Manufacturing
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Board of DirectorsWilliam Yuan (Chairman of the Board)
● Chairman and CEO of Fortress Hill Holdings, an Asian-based investment banking firm.
● 23 years in global finance experience.● Key strategist and advisor to international institutions. U.S.
companies include Amgen Corp., Biogen, GE Capital, Warner Brothers Studios, and Fox News.
● Guided leading Asian institutions like Sina.com, Shanghai Petrochemicals, Jinlia Pharmaceutical and Tsingtao Beer Corp.Led Merrill Lynch Asset Management Asia,
● Managed one of the largest pension / retirement funds in the world, with a $488 billion portfolio.
● Member of the International Who’s Who of Finance, Technology, Media and Telecom.
● B.S. in Economics from Cornell University● Attended as a Mason Fellow at Harvard University’s John F.
Kennedy School.
Lauren Chung, Ph.D.
● 20 years of healthcare investment management and advisory experience.● Founded MINLEIGH LLC. identifying, evaluating and partnering with
companies for investments and various strategic, operational, and commercial planning, as well as providing growth capital.
● Managing Director in Healthcare Research at WestPark Capital.● Former Senior Healthcare Equity Analyst at Maxim Group. ● Co Founder of Tokum Capital , a global healthcare fund.● Managed healthcare investment portfolios at RBR Capital, Kingdon
Capital, and Pequot Capital. ● Recognized research scientist conducting cutting edge research in the field
of Alzheimer’s disease and Angelman Syndrome at Massachusetts General Hospital/Harvard Medical School and Boston Children’s Hospital.
● Serves as a board member in various private healthcare companies. ● PhD in Neuropathology from Columbia University-College of Physicians &
Surgeons, and a BA with honors in Biochemistry and Economics from Wellesley College.
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Rob Davidson
● CEO of CURE Pharmaceutical ● Former President and CEO of InnoZen Inc., CEO of Gel Tech LLC,
CEO of Biodelivery Technologies Inc., and Director of HealthSport Inc.
● ODF expert responsible for the development of several drug delivery technologies and commercial brand extensions.
● Has worked with brands such as Chloraseptic™, Suppress™, as well as Pediastrip™, a private label electrolyte oral thin film.
● B.S., Biological Life Sciences, University of the State of New York, Excelsior College.
● Master’s Certificate, Applied Project Management , Villanova University
● Master’s, Public Health from American Military University, Virginia
● Masters in Health and Wellness from Liberty University, Virginia ● Certified Performance Enhancement Specialist and Fitness
Nutrition Specialist, National Academy of Sports Medicine● Post-Graduate Qualification, University of Cambridge.
Anya Goldin
● 28 years of experience in law, private equity, venture capital, healthcare and telecommunications industries.
● Former international business consultant ● A practicing attorney at Nolan Heimann law firm ● Co-founded Provenance Laboratories, a technology start-up. ● 17 years in leadership as a managing partner at Latham & Watkins ● Served as the General Counsel, Vice President and Chair of the Risk
Management Committee of a $20-billion London Stock Exchange-listed conglomerate and served on the boards of eight public and private companies in Europe, Russia, India and the UK
● Vice Chair of the Board of Directors for a global private equity fund ● On the Advisory Board of a California private equity fund, Lumia Capital.● On the Board of Trustees of Westmark School, and on the Board of the LA
Chapter of Berkeley Law Alumni ● A member of the State Bar of California● BA in Mass Communications from University of California Berkeley● JD from University of California Berkeley School of Law
Board of Directors(continued)
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Board of Directors(continued)
Joshua Held
● Currently the President of Form Factory Inc. a wholly owned subsidiary of Acreage Holdings (ARCG.CN) the largest multi-State cannabis operator licensed in 20 States.
● Founder and CEO of Chemistry Holdings, Inc. a formulation technology company that creates innovative, sustainable delivery systems for a variety of industries. Chemistry Holdings was recently acquired by Cure Pharmaceutical.
● CEO and founder of Made by Science (rebranded as Form Factory Inc) . a private company acquired by Acreage Holdings for $160 Million in December of 2018.
● Former Vice President of Investments for JP Morgan, managing more than $100 million in investment dollars for high-net-worth individuals and families.
● Bachelor of Arts from the California State University, Long Beach.
Ruben Jose King-Shaw Jr.
● C-suite positions with leading private companies including Steward Health Care System, LLC, Neighborhood Health Partnership, Inc. and JMH Health Plan.
● Former Board member, Cotiviti Holdings, Inc. and current Board member, Intelligent Retinal Imaging Systems of Pensacola, FL.
● Former Lead Director of the Board at Athenahealth; Independent Living Systems, of Miami, FL; and WellCare Health Plans, Inc. of Tampa, FL.
● Served on the Obama Administration's Medicare Program Advisory and Oversight Committee,
● COO and deputy administrator of the Centers for Medicare and Medicaid Services, George W. Bush administration.
● Advisor, healthcare policy to the Trump Administration.● Senior advisor to the Secretary of the U.S. Treasury, health care tax
policies. ● B.S., Industrial and Labor Relations, Cornell University, Master of
Health Service Administration and a Master of International Business, Florida International University. Advanced studies in Corporate Governance at the Harvard Business School.
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Board of Directors (continued)
Gene Salkind, MD
● Board certified in neurological surgery by the American Board of Neurological Surgery and completed various residencies, fellowships and postgraduate training at Abington Memorial hospital, The Graduate Hospital, Veteran’s Administration Hospital, Pennsylvania Hospital, Children’s Hospital of Philadelphia, and the Hospital of the University of Pennsylvania.
● MD from Temple University School of Medicine and his Bachelor of Arts from the University of Pennsylvania.
● Numerous faculty, hospital and administrative appointments at virtually every major hospital in the northeastern Philadelphia and surrounding areas.
● Prolific pharmaceutical investor including Intuitive Surgical, Pharmacyclics, which grew from less than $1 per share to subsequently being acquired by Abbvie for $250/share, and Centocor, acquired by Johnson & Johnson for $4.9 billion in stock.
● Sits on the board of DermTech, a private company based in San Diego that has become the global leader in non-invasive dermatological molecular diagnostics.
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Advisors
Michael Willner, Esq.
● Founder of Willner Properties Services, Inc., a PA based real estate development, leasing and management company specializing in both commercial and residential properties.
● Founder of Willner Capital, Inc., a FL based investment concern that has played an activist role with several publicly traded companies.
● Investor in biotech, technology and security companies, with recent focus in cannabis related pharmaceutical companies
● Served on the Board of Directors of publicly traded Meridian Bank, served as Vice Chairman of the Board of Directors of Intervoice, Inc.
● Held positions at Milbank, Tweed, Hadley & McCloy and Arthur Andersen & Company
● Juris Doctor degree from Emory University Law School and CPA
Michael Neely, MD
● Director of the University of Southern California Laboratory of Applied Pharmacokinetics, which has been at the forefront of nonparametric population pharmacokinetic modeling techniques and dose optimization for individual patients for over 35 years.
● Associate Professor of Pediatrics, Clinical Scholar at the University of Southern California (USC) and at Children’s Hospital Los Angeles.
● Research and clinical interests are in pediatric clinical pharmacometrics, including population pharmacokinetic and pharmacodynamic modeling, pharmacogenomics, simulation, and most importantly, use of models to optimize therapy for individual patients.
● Member of the United States Food and Drug Administration Anti- infective Drug Advisory Committee and board certified in pediatrics, pediatric infectious diseases and a Fellow of the American College of Clinical Pharmacology.
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Advisors (continued)
Teresa Virgallito
● Expert in physical and mechanical encapsulation, ingredient engineering, food law regulations and food safety, microbiology and chemical instrumentation.
● Previously EVP of Chemistry Holdings, Inc. ● She has developed drug delivery and formulation solutions
for Procter & Gamble, Kraft, Unilever, Cargill, the U.S. Army, and the U.S. Navy.
● Through her research and commercialization endeavors, she has gained a wealth of knowledge and expertise in regard to the following encapsulation methods: Co-acervation, In-situ Polymerization, Interfacial Polymerization, Fluid Bed Technology, Spray Chilling, Hot Melt Systems, Prilling, Pan Coating, Phase Separation, and Spray Drying.
● Member of the Controlled Release Society active on several CRS committees.
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CompanyDisclaimer
This Investor Presentation is supplied for informational purposes only and does
not constitute (1) an offer to sell, or the solicitation of an offer to buy, any securities of CURE Pharmaceutical, or (2) a promise or representation that any
such offer will be made to the recipient or any other party.
The offering is being made only to qualified investors. The offering shall be made
pursuant to documents reasonably acceptable to the Company and the Investors, which agreements shall contain, among other things, (i) short form, basic representations and warranties by the Company, and (ii) covenants of the Company reflecting the provisions set forth herein and appropriate conditions of closing.
Documents to be drafted by counsel to the company. Read those documents
before making an investment decision. The securities are being offered in reliance upon exemptions from registration under the Securities Act of 1993 and only in the states in which the offering of securities is registered or is exempt from registration and by broker-dealers authorized to do so.
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Credits Title page photograph: copyright © Paul Bradbury, iStock
References:
1. Zhong, Wenjun et al. Age and Sex Patterns of Drug Prescribing in a Defined American Population (2013) Mayo Clinic Proceedings, Volume 88, Issue 7, 697-707 Retrieved from: https://www.mayoclinicproceedings.org
2. Marcum, Z. et al, Medication Nonadherence: A Diagnosable and Treatable Medical Condition (2013 May 22) JAMA; 309(20): 2105–2106. doi: 10.1001/jama.2013.4638 Retrieved from: https://www.ncbi.nlm.nih.gov
3. Fields, J. et al. (2015). Pill Properties that Cause Dysphagia and Treatment Failure. Current Therapeutic Research, Clinical and Experimental, 77, 79–82. doi:10.1016/j.curtheres.2015.08.002. Retrieved from: https://www.ncbi.nlm.nih.gov
4. Industry Research, 2018-2023 Global Melatonin Consumption Market Report (2018, Aug 2) Retrieved from: https://www.industryresearch.co
5. Zion Market Research, Global Erectile Dysfunction Drugs Market Will Reach USD 7.10 Billion by 2024 (2018, Oct) Retrieved from: https://www.globenewswire.com
6. MarketsandMarkets Inc., Vitamin D Market by Analog (Vitamin D2, Vitamin D3), Form (Dry, Liquid), Application (Functional Food & Beverage, Pharma, Feed, and Personal Care), End User (Children, Adult, and Pregnant Women), Iu Strength and Region - Global Forecast to 2025, (2019, May) Retrieved from: https://www.marketsandmarkets.com
7. Grandview Research, Curcumin Market Size, Share & Trends Analysis Report By Application (Pharmaceutical, Food, Cosmetics), By Region (Asia Pacific, North America, CSA, Europe, MEA), And Segment Forecasts 2018 - 2025 (2018, Sep) Retrieved from: https://www.grandviewresearch.com
8. Technavio Research, Global CBD Oil Market Analysis - Size, Trends and Forecast 2018-2022), (2018, July) Retrieved from: https://www.businesswire.com
9. Market Study Report, Global Medical Cannabis Market Insights, Forecast to 2025, (2019, June) Retrieved from: https://www.marketstudyreport.com