Hacking AMR 2019 13-15 December 2019, Stockholm, Sweden

Participant package

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Contents

Welcome to Hacking AMR 2019! ............................................................................................. 3

The Challenge: Antimicrobial resistance .................................................................................. 4

How to prepare – Before and during the Hackathon .............................................................. 5

Tips for a successful hackathon ................................................................................................ 6

What to Expect: Weekend Agenda .......................................................................................... 7

Judging Criteria ......................................................................................................................... 8

Resources for participants ....................................................................................................... 9

Mentors’ Schedule ................................................................................................................. 10

Mentors .................................................................................................................................. 11

Judges ..................................................................................................................................... 14

Prizes and Awards .................................................................................................................. 16

Collaborating partners ........................................................................................................... 17

About JPIAMR ......................................................................................................................... 18

About Hacking Health............................................................................................................. 18

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Welcome to Hacking AMR 2019! You will be participating in a weekend-long hackathon that breaks down barriers to healthcare innovation. Hacking AMR 2019 will bring together healthcare professionals, programmers, designers, policy analysts, entrepreneurs, patients, and more. The goals of the event are:

1. To use the Digital World to challenge and disrupt conventional antimicrobial resistance (AMR) Research models;

2. To design new ways to get the most out of the AMR research innovations; 3. To find breakthrough solutions to the AMR challenge; 4. To raise awareness about important issues, and; 5. To bring people together under a common goal.

After the hackathon, we are hoping that teams will take their innovative digital work product/ mock-up/prototype and subsequently refine, improve, and scale it.

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The Challenge: Antimicrobial resistance Antimicrobial resistance is the ability of a microorganism to survive and grow in the presence of antimicrobial drugs. Resistance is generated through gene mutation or by the acquisition of genetic information through horizontal gene transfer. Antimicrobial resistance becomes a problem when antimicrobials used to treat infectious diseases are no longer effective. Antibacterials, commonly known as antibiotics, act on bacteria. Other antimicrobials include antifungals, antivirals and anti-parasitics. The presence of an antibiotic provides the resistant bacteria with a selective growth advantage in the infected host or environment. These resistant bacteria can then spread more widely within a population, or to other populations or environments. It is therefore critically important to further understand the emergence and spread of AMR to find ways to prevent and control infections. AMR is particularly problematic because the discovery and development of novel antibiotics has slowed while antibiotic use to treat bacterial infection has increased. In addition, the routine use of antibiotics in food animal production also significantly increases the probability of developing resistance. The global challenge to address AMR goes beyond the production of new antibiotics and therapies. Reducing demand for new antibiotics through public awareness, infection prevention and control, prudent and rational use of antibiotics in One Health, as well as effective diagnosis and surveillance of antibiotic-resistant infections and antibiotic use, are crucial when dealing with this problem globally. More information on AMR European Centre for Disease Prevention and Control (ECDC): Antimicrobial resistance WHO: Antimicrobial resistance

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How to prepare – Before and during the Hackathon Are you excited about hacking? We are too! Here are a few things to think about:

Before arriving at the hackathon • Do some initial research to clearly define and articulate your challenge statement • Post your idea on Sparkboard here: https://hacking-amr-2019.sparkboard.com • Prepare a 60-second elevator pitch of your idea to present on Friday night • Watch this video: Video 5 - What to expect at the hackathon • Bring the following items: adaptors, charger cables, reusable water bottle.

At the hackathon

• We will have mentors available to answer your questions. • Brainstorming and ideation should only take a few hours. • Spend the bulk of your hackathon time developing & building your prototype. • Leave some time on Sunday to go to the Pitch clinic for help on your Pitch. The

presentation is as important as the prototype! • Hack to win! Bring your best work forward to get a chance to win prizes and

additional in-kind services.

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Tips for a successful hackathon Hackathons can be a lot of fun! To have fun, come with the right attitude and make the most of it. Here are some tips to get you started: 1. Communication

• No judging! Let the ideas flow, so that people can build on each other and foster great ideas.

• Build on the ideas of others: Use “and” instead of “but”. • One voice at a time: Allow others to speak their mind and get your turn! • Focus on the topic and challenge at hand: Keep the discussion on target,

otherwise you can diverge beyond the scope of what you're trying to design for.

2. Ideation • Go for as many new ideas as possible in the brainstorming processBuild on the

ideas of others: Use “and” instead of “but”. • Be visual: Use pen & paper to draw, storyboard, and plan before you build.

Nothing gets an idea across faster than drawing it.

3. Prototyping • Keep in mind that you’re working towards a minimum viable product! • Work towards building something you can demo on Sunday; something that

captures your main ideas. • User feedback is your best friend!

4. Presentation

• Remember that you only have 4 minutes to communicate your solution followed by 3 minute question period from judges. Focus on getting the main points across.

• Aim to build a demo - something you can show by Sunday. Nothing is more powerful than showing something in action.

• Practice, practice, practice your demo for the pitch!

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What to Expect: Weekend Agenda Hackathons are fast-paced, intense, and super fun events. The upcoming event will start on Friday evening, and continue to Sunday. Note: the schedule below is subject to change. Friday December 13 17:00 Registration opens 17:30 Opening remarks 17:45 Guest speakers 19:00 Food 19:15 Sparkboard support & pitch clinic 20:00 One minute pitches of projects ideas posted on Sparkboard 20:30 Team formation and networking 22:00 Venue closes

Saturday December 14 08:00 Venue opens 08:30 Team Hacking AMR starts 12:00 Lunch 12:30 Judging criteria presentation 13:00 Continue Hacking AMR 18:00 Dinner 23:00 Venue closes

Sunday December 15 08:00 Venue opens 09:30 Final hacking & pitch presentation preperation 10:00 Pitch clinic 12:00 Hacking ends and lunch 13:00 Final pitching to judges – 4 minute pitches with 3 minutes for questions 14:00 Judges deliberate & Peoples’ Choice voting 14:30 Announcement of Hacking AMR 2019 winners 14:45 Closing remarks & photo 15:30 Venue closes

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Judging Criteria Part of the fun of a hackathon is the competitive element. Your teams is trying to win the hackathon and mentoring prizes. Hacking AMR 2019 is prioritising collaboration and impact towards the JPIAMR-Virtual Research Institute.

Your four-minute pitch will be evaluating using the DFVI framework. There are additional points for the quality of your pitch presentation.

1. Desirability • The solution considers the user's needs. • Uptake of the solution is likely. • Has the team thought about how they will test with their end-user groups? 2. Feasibility • Is implementation actually possible from a technical, process or change management

perspective? • Has real potential with likelihood for adoption and scale. • Level of insight the team has into how this solution can be deployed. 3. Viability • Quality of the design/user interface/user design (UI/UX). • Has the team thought about a business model that may work? • Is there a clear path to sustainability? 4. Impact • Who will the solution impact? • What is the degree of this impact? • Extent of the impact the solution can have on AMR.

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Resources for participants We know hackers can do a lot with a laptop and Wi-Fi connection… but we have your backs! Useful links Hacking AMR 2019 event webpage Hacking AMR 2019 video series Sparkboard Hacking rules Enlisting a hacking approach to antimicrobial resistance pre-event blog post JPIAMR-VRI webpage

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Mentors’ Schedule

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Mentors Naimul Abd Naimul coaches more than 500 entrepreneurs, social innovators, cooperative teams and startups per year from idea to launch and early-stage growth at Coompanion Stockholm. He organizes and speaks at dozens of startup events and forums, mentors startups at hackathons and pitching events, connects entrepreneurs with the right nodes in the ecosystem, and is also an impact entrepreneur with a growing early-stage portfolio. Naimul has worked extensively in corporate consulting, providing consumer insights and strategic marketing advisory services to more than 20 multinational companies. You can reach out to him here: https://www.linkedin.com/in/naimulabd Till Bachmann Till Bachmann is the Deputy Head of Infection Medicine at the Deanery of Biomedical Sciences at Edinburgh Medical School. He is also Director of Clinical Microbiology and Infectious Diseases MSc and Biomedical Sciences and PhD programmes at The University of Edinburgh and the Zhejiang University –University of Edinburgh Institute in China. Till has a PhD on biosensors from research at University of Stuttgart and The University of Tokyo and a German Habilitation in Analytical Biotechnology. He is an expert in point of care detection of infectious diseases and antimicrobial resistance, conducting research at the interface of biomarkers and rapid diagnostics.

Dr. Niv Bachnoff Dr. Bachnoff is the major designer and developer of Omnix Medicals' Antimicrobial Peptides technology. He is an expert microbiologist versed in all related method-logy, literature and innovations in this field. He has vast experience in peptide-based drug design and the development of native-peptides for therapeutic applications.

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Dr. Vidya Bhardwaj Vidya Bhardwaj is a veterinarian in charge of a busy Microbiology Diagnostic Veterinary Laboratory in Hong Kong. The laboratory’s main work is to test clinical samples from companion animals and production animals including fish, and check for the presence of pathogens and antimicrobial resistance. It runs a few surveillance projects on AMR in animals, animal products and farm environments. Dr. Bhardwaj graduated as a veterinarian in 1998 from The University of Sydney and has since then worked in various clinical veterinary roles in Australia and Hong Kong.

Dr. Eric Brown Dr. Brown is a Distinguished University Professor in the Department of Biochemistry and Biomedical Sciences and member of the M.G. DeGroote Institute for Infectious Disease Research at McMaster University. Dr. Brown is a former Chair of his department and was the founding Director of a leading edge educational program at the nexus of science and commerce, the Biomedical Discovery and Commercialization program. Currently, he is a member of the editorial board of ACS Infectious Diseases, a member of the Advisory Board of the EU’s Joint Programming Initiative on Antimicrobial Research and serves as a College Chair advising the Canadian Institutes of Health Research on peer review. Dr. Brown’s research aims to probe the complex biology that underlies bacterial survival strategies. The goal of these studies is to contribute to fresh directions for new antibacterial therapies. Dr. Sebastian Dümcke Dr. Sebastian Dümcke is the CEO of Clemedi AG, a Swiss startup company developing AMR diagnostics based on DNA sequencing and machine learning algorithms. Before has was a bioinformatic researcher in basic research as well as cancer diagnostics. His interests lie in predictive modeling of AMR as well as data driven approaches to surveillance and outbreak management.

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Dr. Diarmaid Hughes Dr. Hughes is a professor of medical bacteriology at Uppsala University. His expertise is in bacterial genetics and microbiology. He is the leader of the microbiology platform in the IMI ENABLE consortium working on the development of novel antibiotics targeting Gram-negative bacteria. He is also interested in the evolution of mechanisms of resistance to antibiotics, and in the relationship between antibiotic resistance and bacterial fitness.

Annegret Schneider Annegret has a background in health psychology and is currently researching health communication at the Robert Koch Institute in Germany. Prior experiences include providing behavioural science expertise concerning infection prevention and control interventions with a focus on antibiotic resistance to UK policy agencies. She has further worked on the evaluation of a large EU-funded e-Health intervention and investigated patients’ experiences. She has experience in using quantitative and qualitative methods and in clinical trials and implementation research.

Amanda Warner Amanda is a learning and game designer who is passionate about positive real-world impact. Her work includes interactive, digital learning on topics such as immunization and tuberculosis, as well as social impact games about misinformation. She has collaborated on projects with nonprofits including the World Health Organization, Bill & Melinda Gates Foundation, Humanitarian Leadership Academy, UNICEF, Transparency International Norway, and The Union. You can see examples of her work at www.amanda-warner.com

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Anna Zorzet Dr. Zorzet did her Masters in Molecular Biotechnology in 2002. She completed her Master’s project at the Food Administration on a Matlab classifier for allergenic proteins. She then did research training in Melbourne, Australia, at the Ludwig Institute for cancer research. After coming back to Sweden, she completed her PhD in medical microbiology with a focus on antibiotic resistance at Uppsala University in 2010. She then moved into the policy field when she joined ReAct, in January 2011 and took over as Head of the office in 2014. In addition to her research on compensatory mutations for antibiotic resistance, her publications include work on how to overcome scientific and structural bottlenecks in antibacterial discovery and development, access to sustainable antibiotics, diagnostics, how antibiotics affect the Sustainable Development Goals. Johan Bengtsson-Palme Johan Bengtsson-Palme does research in microbiology and microbial ecology, with a particular focus on antibiotic resistance in environmental bacterial communities. To investigate this, he uses bioinformatics and metagenomics, i.e. large-scale sequencing of total DNA from all bacteria in a sample.

Judges Linus Sandegren Ph.D., Associate professor, in medical bacteriology with a special interest in mobile genetic elements and antibiotic resistance evolution. Member of the management group of Uppsala Antibiotic Center. Central themes of his research are fundamental aspects of how resistant bacteria evolve and spread over time in patients, in hospital settings and in environments contaminated by antibiotics such as sewage.

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Maria Smith Maria Smith has experience working with sustainability issues in grocery retail, engineering industry and the service sector, among others. She is the General secretary of Axfoundation - an independent, non-profit organization working practically and concretely towards building a sustainable society. Axfoundation believes that entrepreneurship and broad collaborations with many actors in society are necessary for change and through practical solutions aim to inspire others and act for change. One important area is antibiotic resistance.

Marianne Sunde Dr. Sunde is a senior researcher in veterinary microbiology at the Norwegian Veterinary Institute. She has experience in research on antimicrobial resistance and has been a key person in bacteriological diagnostics. She is involved in monitoring of resistance in the veterinary sector in Norway. She has a strong national and international network in veterinary microbiology and she has been project leader for national and international research projects. Maria Thuvesson Maria Thuveson, Executive Director of the Swedish Research Council, is the deputy Director General and assists the Director General with heading the public authority. The Executive Director is in charge of the Swedish Research Council's heads of department. She is also the head of the Department of Administration and holds HR responsibility for the Ethics Review Appeals Board´s office staff. Jannik Vollmer Jannik Vollmer is an expert for systems pharmacology and digital health. He advocates model-informed drug discovery and development and the use of digital health solutions to support key decision making along the elaborate path from the laboratory to everyday use of medications. Using modelling and simulation, he supports pre-clinical and clinical development at any stage, including target validation, compound selection, animal-to-human translation, dose finding and phase I to III clinical trials. His main expertise is in the field of novel biotherapeutics and anti-infectives.

Prizes and Awards Hacking AMR 2019 will award a Grand Prize to the Winning Team. The Grand Prize will consist of 5-15 hours of post-event mentoring sessions over a 6-month period with skilled mentors, experts in their fields, to further assist with bringing forward the idea you developed during this event. Prize mentorship provided by LYO-X is providing Quantitative Systems Pharmacology (QSP) and mathematical PK/PD modelling services for the biotechnology and pharmaceutical industry. LYO-X’s main expertise is the pharmacology of biotherapeutics and novel therapeutic formats including antibodies, bi-specifics, antibody-drug conjugates (ADCs), fusion proteins, peptides, gene therapies and siRNAs. LYO-X is well recognized as one of the few providers worldwide in this niche domain and to date has been supporting over 100 companies globally in translating their highly innovative therapeutic molecules to patients. LYO-X supports compound design and selection, PK/PD studies, toxicology studies, early translation of PK and PD from animal to human including first in human dose estimation and clinical dose selection. We also support dose finding studies and phase III studies with population PK/PD modelling and clinical trial simulations. The disease areas in which we have an in-depth expertise are infectious diseases, immuno-oncology, ophthalmology, autoimmune and inflammatory diseases, metabolic diseases and rare diseases. Da Volterra is a clinical stage biotechnology company whose vision is to be a trusted and acknowledged leader in the microbiota and infectious diseases fields. Our mission is to discover, develop and bring to market safe and novel therapeutic options, to prevent and cure life-threatening diseases. HéliApps is a young innovative IT company developing advanced expert systems and datamining solutions supporting a wide range of activities in health, aeronautics and beyond.

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Collaborating partners

Produced in association with

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About JPIAMR The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) is a global collaborative platform that has engaged 27 nations to curb antibiotic resistance (AMR) with a One Health approach. The initiative coordinates national funding to support transnational research and activities within the six priority areas of the shared JPIAMR Strategic Research and Innovation Agenda – therapeutics, diagnostics, surveillance, transmission, environment and interventions. To date JPIAMR has supported research and network projects, with funding of approximately 79 million euro.

The JPIAMR is currently developing a platform to extend shared research capabilities on a global scale through the Virtual Research Institute (JPIAMR-VRI).

About Hacking Health JPIAMR has commissioned Hacking Health to organize a hackathon and facilitate your experience in helping us tackle AMR.

Hacking Health is an international non-for-profit organisation born in Canada that catalyses collaboration by empowering stakeholders to build innovative and meaningful solutions to healthcare challenges. The organisation has 40 vibrant chapters across the world on 5 continents.

Hacking Health’s goal is to promote greater innovation in healthcare through collaboration by putting physicians and healthcare professionals at the centre of the innovation process. Hacking Health aim to create spaces for collaborative, interdisciplinary experimentation and brings together physicians, health professionals, patients and technologists to work together to tackle tangible frontline problems with creative solutions.

Hacking Health organises innovation competitions such as hackathons and design challenges, as well as cafes, conferences, clinics and workshops. All these events bring the healthcare and technology ecosystems together to connect, brainstorm and build creative solutions. Since 2012, Hacking Health has organized 150 health focused hackathons and design challenges across the globe. Moreover, the events have brought together over 12,500 people and allowed teams to work on over 1,500 projects to find concrete solutions to problems in healthcare. Hacking Health is the only organization that can claim this.

Hacking Health partners with hospitals, universities, research institutes, associations, and other organisations on an ongoing basis to develop projects and foster a culture of constant and open innovation.

To learn more about Hacking Health, please visit: www.hacking-health.org

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