Question: Why do people prefer their coffee in certain ways? Sub question 1: what’s the purpose of taste? Sub question 2: How is taste organized in the periphery, Sub question 3 : How is the information generated in the periphery presented to the CNS? Gustation signalling pathways: who ever said you can’t account for tastes? Kyle Shanafelt Conclusions/significance : Gustatory taste pathways are hardwired in the brain’s sensory system. Specific tastants don’t determine the response, it’ s the category of cells that are activated by those tastants. Conclusion: These experiments show how taste is broadly hardwired into behavior and how the different taste categories are presented in a unique fashion to the CNS. We transmit specific tastants to our CNS for processing and keep those signals separate so as to assign these different signals the appropriate response. Drosophila response is determined by the category of cells actiavted Taste inputs into the mushroom bodies remain within taste modality subgrouping. Taste is organized into 5 distinct modalities Taste Organization in the Periphery References: "Black vs Regular Coffee, Which Is Better for Your Health." Frestyls. N.p., n.d. Web. <http://freestyls.com/black-coffee-vs-regular- coffee-which-is-better-for-your-health/>. Davis, Jim. Introduction. Garfield. Partridge Green: Ravette, 2001. N. pag. Amazon. Web. Duffy, Joseph B. "GAL4 System Indrosophila: A Fly Geneticist's Swiss Army Knife." Genesis 34.1-2 (2002): 1-15. Web. Dura, Jean-Maurice. "Brain Development and Function: Mushroom Body Genetics." N.p., n.d. Web. 02 June 2015. <http://www.igh. cnrs.fr/equip/jmdura/>. Hiroi, Makoto, Teiichi Tanimura, and Frédéric Marion-Poll. "Hedonic Taste in Drosophila Revealed by Olfactory Receptors Expressed in Taste Neurons." PLoS ONE 3.7 (2008): n. pag. Web. Kirkhart, C., and K. Scott. "Gustatory Learning and Processing in the Drosophila Mushroom Bodies." Journal of Neuroscience 35.15 (2015): 5950-958. Web. "Taste (Gustation)." The Physiology of Taste. N.p., n.d. Web. 02 June 2015. <http://www.cf.ac. uk/biosi/staffinfo/jacob/teaching/sensory/taste.html>. Drosophila Mushroom Bodies: The Learning Center Conclusions/significanc e: Taste is kept in the same modality as it moves up the CNS in fruit flies. “Sweet” or attractive signals stimulated by fructose and those stimulated by sucrose lead to very similar activation patterns in the fly mushroom bodies. Drosophila are then able to translate this information to inform responses Peripheral Presentation to the CNS Drosophila learn to not respond to negatively associated tastants. Olfaction distinguishes between many different stimulants Purpose of Taste (Gustation): Taste is all about making sure we eat high energy things and don’t eat poisonous things. Think binary: tastants are either attractive or repulsive

Gustation Signalling Pathways- June 2015

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Page 1: Gustation Signalling Pathways- June 2015

Gustation signalling pathways: who ever said you can’t account for tastes?

Kyle Shanafelt

Conclusions/significance: Gustatory taste pathways are hardwired in the brain’s sensory system. Specific tastants don’t determine the response, it’s the category of cells that are activated by those tastants.

Conclusion: These experiments show how taste is broadly hardwired into behavior and how the different taste categories are presented in a unique fashion to the CNS. We transmit specific tastants to our CNS for processing and keep those signals separate so as to assign these different signals the appropriate response. Drosophila response is determined

by the category of cells actiavted

Taste inputs into the mushroom bodies remain within taste modality subgrouping.

Taste is organized into 5 distinct modalities

Taste Organization in the Periphery

References: "Black vs Regular Coffee, Which Is Better for Your Health." Frestyls. N.p., n.d. Web. <http://freestyls.com/black-coffee-vs-regular-coffee-which-is-better-for-your-health/>.Davis, Jim. Introduction. Garfield. Partridge Green: Ravette, 2001. N. pag. Amazon. Web.Duffy, Joseph B. "GAL4 System Indrosophila: A Fly Geneticist's Swiss Army Knife." Genesis 34.1-2 (2002): 1-15. Web.Dura, Jean-Maurice. "Brain Development and Function: Mushroom Body Genetics." N.p., n.d. Web. 02 June 2015. <http://www.igh.cnrs.fr/equip/jmdura/>.Hiroi, Makoto, Teiichi Tanimura, and Frédéric Marion-Poll. "Hedonic Taste in Drosophila Revealed by Olfactory Receptors Expressed in Taste Neurons." PLoS ONE 3.7 (2008): n. pag. Web.Kirkhart, C., and K. Scott. "Gustatory Learning and Processing in the Drosophila Mushroom Bodies." Journal of Neuroscience 35.15 (2015): 5950-958. Web."Taste (Gustation)." The Physiology of Taste. N.p., n.d. Web. 02 June 2015. <http://www.cf.ac.uk/biosi/staffinfo/jacob/teaching/sensory/taste.html>.

Drosophila Mushroom Bodies: The Learning Center

Conclusions/significance: Taste is kept in the same modality as it moves up the CNS in fruit flies. “Sweet” or attractive signals stimulated by fructose and those stimulated by sucrose lead to very similar activation patterns in the fly mushroom bodies. Drosophila are then able to translate this information to inform responses

Peripheral Presentation to the CNS

Drosophila learn to not respond to negatively associated tastants.

Olfaction distinguishes between many different stimulants

Purpose of Taste (Gustation):Taste is all about making sure we eat high energy things and don’t eat poisonous things.

Think binary: tastants are either attractive or repulsive