Guilherme Garcia PhD · 2020. 7. 22. · 1 Guilherme Garcia PhD Assistant Professor of Biomedical Engineering Marquette University & The Medical College of Wisconsin 8701 Watertown

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Guilherme Garcia PhD

Assistant Professor of Biomedical Engineering Marquette University & The Medical College of Wisconsin

8701 Watertown Plank Rd Milwaukee, WI 53226

Work Phone: (414) 955-4466 Email: [email protected]

DATE OF DOCUMENT

July 21, 2020 ACADEMIC TRAINING

03/1996 - 07/1999 Bachelor of Science in Physics Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

08/1999 - 07/2001 Master of Science in Physics Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

08/2001 - 01/2005 Doctor of Philosophy in Physics Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

POST-DOCTORAL FELLOWSHIPS

03/2005 - 10/2008 The Hamner Institutes for Health Sciences, Computational Biology Division, Research Triangle Park, NC, USA Mentor: Julia Kimbell, PhD

11/2008 - 01/2011 Cystic Fibrosis Research Center and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA Mentors: Richard Boucher, MD and Timothy Elston, PhD

02/2011 - 02/2012 Department of Physics Universidade Federal de Minas Gerais, Brazil Mentor: Jafferson Silva, PhD

FACULTY APPOINTMENTS

03/2012 - 09/2012 Assistant Professor Universidade Federal de São João Del Rei Ouro Branco, MG, Brazil

10/2012 - present Assistant Professor (research track) (secondary appointment after 07/2016) Department of Otolaryngology and Communication Sciences Medical College of Wisconsin Milwaukee, WI, USA

07/2016 - present Assistant Professor (traditional tenure-track) Department of Biomedical Engineering Marquette University & The Medical College of Wisconsin Milwaukee, WI, USA

mailto:[email protected]

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HIGHLIGHTS, HONORS, AND AWARDS

10/2012 Best Poster Award X-meeting 2012, Signaling and Metabolic Networking, Ontologies, Systems Biology (Received by my M.S. student Tauanne Amarante)

05/2014 Medical College of Wisconsin Affiliated Hospital (MCWAH) Research Award (Received by my resident Corbin Sullivan M.D.)

10/2014 Best Poster Award (3rd highest score among 115 posters) 2014 Medical Student Research Day Poster Session Medical College of Wisconsin (Received by my medical student Gabriel Oland)

10/2014 Best Resident Basic Science Research Award 2014 Wisconsin Society of Otolaryngology meeting (Received by my resident Ruchin Patel M.D.)

10/2015 Best Poster Award (7th highest score among 106 posters) 2015 Medical Student Research Day Poster Session Medical College of Wisconsin (Received by my medical student Courtney Gaberino)

05/2016 Best Poster Award (2nd place among 95 posters) American Rhinologic Society (ARS) meeting at the Combined Otolaryngology Spring Meetings (COSM) 2016 (Received by my medical student Courtney Gaberino)

02/2017 Eby Award (Best manuscript of the year) (1st place among 5 residents) Department of Otolaryngology Research Day, Medical College of Wisconsin (Received by my resident Kevin Casey)

05/2017 Medical College of Wisconsin Affiliated Hospital (MCWAH) Research Award (Received by my resident Kevin Casey M.D.)

07/2018 Cover of The Laryngoscope - Figure from Lin et al. (2018)

12/2018 Outstanding Graduate School Educator for academic year 2017-2018 Medical College of Wisconsin

06/2019 Eby Award (Best manuscript of the year) (1st place among 4 residents) Department of Otolaryngology Research Day, Medical College of Wisconsin (Received by my resident David Campbell)

09/2019 Community of Innovators Award (1 out of 5 faculty to receive this award in 2019), Medical College of Wisconsin

GRANTS

GRANTS AS PRINCIPAL INVESTIGATOR

ACTIVE GRANTS

Title: Determining the phenotype of airway collapse in obstructive sleep apnea Source: Advancing a Healthier Wisconsin Endowment Project: 5520494 Role: Principal Investigator (20% effort)

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Dates: 01/01/2019 - 12/31/2020 Direct costs: $100,000/year PAST GRANTS

Title: Incorporating concepts of environment control at the international space station into a transport phenomena course

Source: NASA Wisconsin Space Grant Consortium Project: Higher Education Incentives Grant - HEI19_4.0 Role: Principal Investigator (5% effort) Dates: 03/01/2019 - 11/30/2019 Total costs: $7,500 Title: Role of pharyngeal compliance in the pathophysiology of obstructive sleep apnea Source: Clinical & Translational Science Institute (CTSI) of Southeast Wisconsin Role: Principal Investigator (75% effort) Dates: 04/01/2014 – 03/31/2016 Direct costs: $76,666/year POSTDOCTORAL GRANTS

Title: Airway surface liquid (ASL) volume regulation (in Portuguese) Source: CNPq (Brazilian Science Agency) Role: Principal Investigator (100% effort) Dates: 03/01/11 – 03/01/12 Total costs: $24,000 Title: Nasal airflow in humans (in Portuguese) Source: CNPq (Brazilian Science Agency) Role: Principal Investigator (100% effort) Dates: 03/01/05 – 09/01/06 Total costs: $38,000

GRANTS AS CO-INVESTIGATOR

ACTIVE GRANTS

Title: An Interactive, Patient-Specific Virtual Surgical Planning System for Upper Airway Obstruction Treatments

Source: NIH / NIBIB - SBIR Project: R44 EB023121 Role: Co-Investigator (10% effort) PI: Andinet Enquobahrie (Kitware Inc.) Dates: 09/23/2019 - 09/22/2020 Total costs: $849,999 Title: Modifications and Improvements to Hybrid CFD-PBPK Models for Predictions of Nasal

Corticosteroid Deposition, Absorption and Bioavailability Source: U.S. Food & Drug Administration (FDA)

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Project: BAA-PMQWP#220 Role: Co-Investigator PI: Jeffry Schroeter (Applied Research Associates, Inc.) Dates: 10/01/2019 - 09/30/2022

PAST GRANTS

Title: Mechanisms of Anesthetics Cardioprotection / Project III: Modeling of Mitochondria and Cell Function in Anesthetic Cardioprotection

Source: NIH / NIGMS - PPG Project: P01 GM066730 Role: Co-Investigator (10% effort) PI: Zeljko Bosnjak (PPG) / Ranjan Dash (Project III) (Medical College of Wisconsin) Dates: 03/01/2015 - 02/29/2020 Direct costs: $1,165,876/year Title: Improving Topical Drug Delivery for Treatment of Chronic Rhinosinusitis Source: NIH / NHLBI - R01 Project: R01 HL122154 Role: Co-Investigator (10% effort) PI: Julia Kimbell (UNC Chapel Hill) Dates: 04/01/2015 - 03/31/2019 Direct costs: $267,225/year Title: Creating Virtual Surgery Targets & Methods to Improve Outcomes of Nasal Surgery Source: NIH / NIBIB - R01 Project: R01 EB009557 Role: Co-Investigator (20% effort) PI: John Rhee (Medical College of Wisconsin) Dates: 09/15/2014 - 06/30/2018 Direct costs: $266,165/year Title: Computer modeling of surgical outcomes for nasal airway obstruction Source: NIH / NIBIB - R01 Project: R01 EB009557 Role: Co-Investigator PI: John Rhee (Medical College of Wisconsin) Dates: 10/01/2012 - 03/31/2014 Direct costs: $266,140/year Title: Novel radiographic measures of olfactory dysfunction in aging Source: Center on Aging at the Medical University of South Carolina Role: Co-Investigator (5% effort) PI: Rodney Schlosser (Medical University of South Carolina) Dates 6/1/2017 - 5/31/2018 Direct costs: $30,000 (MCW subcontract = $9,000)

Title: Rhinomanometry performed via computational fluid dynamics (in Portuguese)

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Source: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Project: 12/20823-9 Role: Co-Investigator PI: Richard Voegels (Universidade de São Paulo) Dates: 10/01/2013 – 03/31/2016

Title: Modeling the Pediatric Upper Airway using Anatomic Optical Coherence Tomography

and Computational Fluid Dynamics Source: NIH / NHLBI - R01 Project: R01 HL105215 Role: Co-Investigator (5% effort) PI: Brian Wong (UC Irvine) Dates 10/01/2012 - 09/30/2014 Direct costs: $596,973/year POSTDOCTORAL GRANTS

Title: Pulmonary epithelia in health and disease. Project IV: The role of airway surface liquid nucleotides/nucleosides in volume homeostasis

Source: NIH/NHLBI P01 Project: P01 HL034322 Role: Postdoctoral Fellow (100% effort) PI: Richard Boucher (UNC Chapel Hill) Dates: 11/01/08 – 02/10/11 Total costs: $496,411/year

Title: Mechanism of Species Dependent Environmental Lung Injury Source: NIH/NIEHS Project: P01 ES011617 Role: Postdoctoral Fellow PI: Edward Postlethwait (University of Alabama at Birmingham) / Kimbell (subcontract PI) Dates: 04/01/06 – 10/31/08 Total costs: $1,309,743/year

Title: Age Related Intrahuman Variability in Inhalation Dosimetry Source: U.S. Environmental Protection Agency Role: Postdoctoral Fellow PI: Julia Kimbell (The Hamner Institutes for Health Sciences) Dates: 09/18/06 – 12/31/07

Title: Follow-on development of specific modifications to multi-path particle deposition

model and software interface Source: NIOSH/CDC/EIDIV Project: P.O. # 212-2006-M-18273 Role: Postdoctoral Fellow PI: Julia Kimbell (The Hamner Institutes for Health Sciences) Dates: 08/14/06 – 11/30/07

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PUBLICATIONS

Peer-reviewed journals

1) Basu S., Holbrook L.T., Kudlaty K., Fasanmade O., Wu J., Burke A., Langworthy B., Farzal Z., Mamdani M., Bennett W.D., Fine J.P., Senior B.A., Zanation A.M., Ebert C.S., Kimple A.J., Thorp B.D., Frank-ito D.O., Garcia G.J.M., Kimbell J.S. (2020) Numerical evaluation of spray position for improved nasal drug delivery. Scientific Reports 10, 10568.

2) Campbell D.A., Moghaddam M.G., Rhee J.S., Garcia G.J.M. (2020) Narrowed posterior nasal airway limits efficacy of anterior septoplasty. Facial Plastic Surgery & Aesthetic Medicine, in press. DOI 10.1089/fpsam.2020.0081.

3) Moghaddam M.G.,* Garcia G.J.M.,* Frank-Ito D.O., Kimbell J.S., Rhee J.S. (2020) Virtual septoplasty: A method to predict surgical outcomes for patients with nasal airway obstruction. International Journal of Computer Assisted Radiology and Surgery 15, 725–735. * These authors contributed equally to this work.

4) Borojeni A.A.T.,* Garcia G.J.M.,* Moghaddam M.G., Frank-Ito D.O., Kimbell J.S., Laud P.W., Koenig L.J., Rhee J.S. (2020) Normative ranges of nasal airflow variables in healthy adults. International Journal of Computer Assisted Radiology and Surgery 15, 87-98. * These authors contributed equally to this work.

5) Newsome H., Lin E.L., Poetker D.M., Garcia G.J.M. (2019) The clinical importance of nasal air conditioning: a review of the literature. American Journal of Rhinology & Allergy 33, 763-769.

6) Le T.B., Moghaddam M.G., Woodson B.T., Garcia G.J.M. (2019) Airflow limitation in a collapsible model of the human pharynx: Physical mechanisms studied with fluid-structure interaction simulations and experiments. Physiological Reports 7 (10), e14099, 1-16.

7) Frank-Ito D.O., Kimbell J.S., Borojeni A.A.T., Garcia G.J.M., Rhee J.S. (2019) A hierarchical stepwise approach to evaluate nasal patency after virtual surgery for nasal airway obstruction. Clinical Biomechanics 61, 172-180.

8) Ganjaei K.G., Soler Z.M., Mappus E.D., Worley M.L., Rowan N.R., Garcia G.J.M., Dubno J.R., Eckert M.A., Matthews L.J., Schlosser R.J. (2019) Radiographic changes in the aging nasal cavity. Rhinology 57, 117-124.

9) Kimbell J.S., Basu S., Garcia G.J.M., Frank-Ito D.O., Lazarow F., Su E., Protsenko D., Chen Z., Rhee J.S., Wong B.J. (2019) Upper Airway Reconstruction Using Long-Range Optical Coherence Tomography: Effects of Airway Curvature on Airflow Resistance. Lasers in Surgery & Medicine 51, 150-160.

10) Cherobin G.B., Voegels R.L., Gebrim E.M., Garcia G.J.M. (2018) Sensitivity of nasal airflow variables computed via computational fluid dynamics to the computed tomography segmentation threshold. PLOS ONE 13, e0207178.

11) Ganjaei K., Soler Z.M., Mappus E., Taylor R., Worley M., Mulligan J., Mattos J.L., Rowan N., Garcia G.J.M., Dubno J., Eckert M., Schlosser R.J. (2018) Novel radiographic assessment of the cribriform plate. American Journal of Rhinology & Allergy 32, 175-180.

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12) Lin E.L., Bock J.M., Zdanski C., Kimbell J.S., Garcia G.J.M. (2018) Relationship between degree of

obstruction and airflow limitation in subglottic stenosis. Laryngoscope 128, 1551-1557.

13) Vanhille D.L.,* Garcia G.J.M.,* Asan O., Borojeni A.A.T., Frank-Ito D.O., Kimbell J.S., Pawar S.S., Rhee J.S. (2018) Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance. JAMA Facial Plastic Surgery 20, 63-69. * These authors contributed equally to this work.

14) Perkins E.L., Basu S., Garcia G.J.M., Buckmire R.A., Shah R.N., Kimbell J.S. (2018) Ideal particle sizes for

inhaled steroids targeting vocal granulomas: Preliminary study using computational fluid dynamics. Otolaryngology Head and Neck Surgery 158, 511-519.

15) Pawar S.S., Garcia G.J.M., Rhee J.S. (2017) Advances in technology for functional rhinoplasty: The next frontier. Facial Plastic Surgery Clinics of North America 25, 263-270.

16) Casey K.P., Borojeni A.A.T., Koenig L.J., Rhee J.S., Garcia G.J.M. (2017) Correlation between subjective nasal

patency and intranasal airflow distribution. Otolaryngology – Head and Neck Surgery 156, 741-750.

17) Prisco A.R., Aliseda A., Beckman J.A., Mokadam N.A., Mahr C., Garcia G.J.M. (2017) Impact of LVAD Implantation Site on Ventricular Blood Stagnation. ASAIO Journal 63, 392-400.

18) Bailey R.S., Casey K.P., Pawar S.S., Garcia G.J.M. (2017) Correlation of nasal mucosal temperature with

subjective nasal patency in healthy individuals. JAMA Facial Plastic Surgery 19, 46-52.

19) Gaberino C., Rhee J.S., Garcia G.J.M. (2017) Estimates of nasal airflow at the nasal cycle mid-point improve the correlation between objective and subjective measures of nasal patency. Respiratory Physiology & Neurobiology 238, 23-32.

20) Aliseda A., Chivukula V.K., McGah P., Prisco A.R., Beckman J.A., Garcia G.J.M., Mokadam N.A., Mahr C.

(2017) LVAD Outflow Graft Angle and Thrombosis Risk. ASAIO Journal 63, 14-23.

21) Borojeni A.A.T., Frank-Ito D.O., Kimbell J.S., Rhee J.S., Garcia G.J.M. (2017) Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy. International Journal of Numerical Methods in Biomedical Engineering 33, e2825.

22) Garcia G.J.M., Hariri B.M., Patel R.G., Rhee J.S. (2016) The relationship between nasal resistance to airflow

and the airspace minimal cross-sectional area. Journal of Biomechanics 49, 1670-1678.

23) Dayal A., Rhee J.S., Garcia G.J.M. (2016) Impact of Middle vs. Inferior Total Turbinectomy on Nasal Aerodynamics. Otolaryngology Head and Neck Surgery 155, 518-525.

24) Hariri B.M., Rhee J.S., Garcia G.J.M. (2015) Identifying patients who may benefit from inferior turbinate

reduction using computer simulations. Laryngoscope 125, 2635-2641.

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25) Garcia G.J.M., Schroeter J.D., Kimbell J.S. (2015) Olfactory deposition of inhaled nanoparticles in humans. Inhalation Toxicology 27, 394-403.

26) Patel R.G.,* Garcia G.J.M.,* Frank-Ito D.O., Kimbell J.S., Rhee J.S. (2015) Simulating the nasal cycle with

computational fluid dynamics. Otolaryngology – Head and Neck Surgery 152, 353-360. * These authors contributed equally to this work.

27) Amarante T.D., da Silva J.K.L., Garcia G.J.M. (2014) Effects of airway surface liquid height on the kinetics of extracellular nucleotides in airway epithelia. Journal of Theoretical Biology 363, 427-435.

28) Frank-Ito D.O., Kimbell J.S., Laud P.D., Garcia G.J.M., Rhee J.S. (2014) Predicting post-surgery nasal physiology with computational modeling: Current challenges and limitations. Otolaryngology – Head and Neck Surgery 151, 751-759.

29) Kota P., Buchner G., Chakraborty H., Dang YL., He H., Garcia G.J.M., Kubelka J., Gentzsch M., Stutts M.J.,

Dokholyan N.V. (2014) The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel. Journal of Biological Chemistry 289, 23029-23042.

30) Rhee J.S., Sullivan C.D., Frank-Ito D.O., Kimbell J.S., Garcia G.J.M. (2014) A systematic review of patient

reported nasal obstruction scores. JAMA Facial Plastic Surgery 16, 219-225.

31) Sullivan C.D.,* Garcia G.J.M.,* Frank D.O., Kimbell J.S., Rhee J.S. (2014) Perception of better nasal patency correlates with increased mucosal cooling after surgery for nasal obstruction. Otolaryngology – Head and Neck Surgery 150, 139-147. * These authors contributed equally to this work.

32) Kimbell J.S., Frank D.O., Laud P.D., Garcia G.J.M., Rhee J.S. (2013) Changes in nasal airflow and heat

transfer correlate with symptom improvement after surgery for nasal obstruction. Journal of Biomechanics 46, 2634-2643.

33) Herschlag G.J., Garcia G.J.M., Button B., Tarran R., Lindley B., Reinhardt B., Elston T.C., Forest G. (2013) A mechanochemical model for auto-regulation of lung airway surface layer volume. Journal of Theoretical Biology 325, 42-51.

34) Garcia G.J.M., Boucher R.C., Elston T.C. (2013) Biophysical model of ion transport across human respiratory

epithelia allows quantification of ion permeabilities. Biophysical Journal 104, 716-726.

35) Kimbell J.S., Garcia G.J.M., Frank D.O., Cannon D.E., Pawar S.S., Rhee J.S. (2012) Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages. American Journal of Rhinology & Allergy 26, e94-e98.

36) Rhee J.S., Pawar S.S., Garcia G.J.M., Kimbell J.S. (2011) Toward Personalized Nasal Surgery Using

Computational Fluid Dynamics: A Preliminary Report. Archives of Facial Plastic Surgery 13, 305-310.

37) Schroeter J.D., Garcia G.J.M., Kimbell J.S. (2011) Effects of Surface Smoothness on Inertial Particle Deposition in Human Nasal Models. Journal of Aerosol Science 42, 52-63.

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38) Garcia G.J.M., Rhee J.S., Senior B.A., Kimbell J.S. (2010) Septal deviation and nasal resistance: An investigation using virtual surgery and computational fluid dynamics. American Journal of Rhinology & Allergy 24, e46-e53.

39) Pawar S.S., Garcia G.J.M., Kimbell J.S., Rhee J.S. (2010) Objective measures in aesthetic and functional

nasal surgery: Perspectives on nasal form and function. Facial Plastic Surgery 26, 320-327.

40) Schroeter J.D., Garcia G.J.M., Kimbell J.S. (2010) A computational fluid dynamics approach to assess inter-human variability in hydrogen sulfide nasal dosimetry. Inhalation Toxicology 22, 277-286.

41) Garcia G.J.M., Kimbell J.S. (2009) Deposition of inhaled nanoparticles in the rat nasal passages: dose to

the olfactory region. Inhalation Toxicology 21, 1165-1175.

42) Garcia G.J.M., Schroeter J.D., Segal R.A., Stanek J., Foureman G.L., Kimbell J.S. (2009) Dosimetry of nasal uptake of soluble and reactive gases: a first study of inter-human variability. Inhalation Toxicology 21, 607-618.

43) Garcia G.J.M., Tewksbury E.W., Wong B.A., Kimbell J.S. (2009) Interindividual variability in nasal filtration

as a function of nasal cavity geometry. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22, 139-155.

44) Garcia G.J.M., Bailie N., Martins D.A., Kimbell J.S. (2007) Atrophic rhinitis: A CFD study of air conditioning

in the nasal cavity. Journal of Applied Physiology 103, 1082-1092.

45) Carey S.A., Minard K.R., Trease L.L., Wagner J.G., Garcia G.J.M., Ballinger C.A., Kimbell J.S., Plopper C.G., Corley R.A., Postlethwait E.M., Harkema J.R. (2007) Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques. Toxicologic Pathology 35, 27-40.

46) Garcia G.J.M., Silva J.K.L. (2006) Interspecific allometry of bone dimensions: A review of the theoretical

models. Physics of Life Reviews 3, 188-209.

47) Silva J.K.L., Garcia G.J.M., Barbosa L.A. (2006) Allometric scaling laws of metabolism. Physics of Life Reviews 3, 229-261.

48) Barbosa L.A., Garcia G.J.M., Silva J.K.L. (2006) The scaling of maximum and basal metabolic rates of

mammals and birds. Physica A 359, 547-554.

49) Dickman R., Garcia G.J.M. (2005) Absorbing-state phase transitions with extremal dynamics. Physical Review E 71, 066113.

50) Garcia G.J.M., Dickman R. (2004) Asymmetric dynamics and critical behavior in the Bak-Sneppen model.

Physica A 342, 516-528.

51) Garcia G.J.M., Dickman R. (2004) On the thresholds, probability densities, and critical exponents of Bak-Sneppen-like models. Physica A 342, 164-170.

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52) Garcia G.J.M., Silva J.K.L. (2004) On the scaling of mammalian long bones. Journal of Experimental Biology207, 1577-1584.

53) Garcia G.J.M., Dickman R. (2004) On singular probability densities generated by extremal dynamics.Physica A 332, 318-336.

54) Kokshenev V.B., Silva J.K.L., Garcia G.J.M. (2003) Long-bone allometry of terrestrial mammals and thegeometric-shape and elastic-force constraints of bone evolution. Journal of Theoretical Biology 224, 551-556.

Manuscripts currently under review

1) Cherobin G.B., Voegels R.L., Pinna F.R., Gebrim E.M.M.S., Bailey R.S., Garcia G.J.M. (2020)Rhinomanometry vs. computational fluid dynamics: A comparison of two techniques to quantify nasalresistance. Submitted to the American Journal of Rhinology & Allergy.

2) Little R.E., Schlosser R.J., Le T.B., Rhee J.S., Garcia G.J.M. (2020) Age-related changes in olfactory cleftanatomy and airflow using computational fluid dynamics. Submitted to the American Journal of Rhinology& Allergy.

Invited Editorials/ Commentaries

1) Garcia G.J.M. (2020) lapdMouse: A data archive for advancing computational models of inhaled aerosoldosimetry. Journal of Applied Physiology 128, 307-308.

2) Garcia G.J.M. and Woodson B.T. (2020) The collapsing anatomical structure is not always the primary siteof flow limitation in obstructive sleep apnea. Journal of Clinical Sleep Medicine 16, 345-346

Letters to the Editor

1) Garcia G.J.M., Patel R.G., Frank-Ito D.O., Kimbell J.S., Rhee J.S. (2015) Response to Dr Chung’s question onsimulating the nasal cycle with computational fluid dynamics. Otolaryngology – Head and Neck Surgery153, 308-309.

2) Garcia G.J.M., Frank-Ito D.O., Kimbell J.S. (2014) In reference to Regional peak mucosal cooling predictsthe perception of nasal patency. Laryngoscope 124, E210.

Book Chapter

1) Garcia G.J.M., Picher M., Zuo P., Okada S.F., Lazarowski E.R., Button B., Boucher R.C., Elston T.C. (2011)Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. InPurinergic regulation of respiratory diseases (M. Picher and R.C. Boucher, eds.), Chapter 3, SpringerPublishing, ISBN-13: 978-9400712164. Subcell Biochem. 55, 51-74.

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Technical Newsletter

1) Garcia G.J.M., Schroeter J.D., Kimbell J.S. (2006) Sniffing out airflow and transport processes in the nasalcavity. Fluent News Fall 2006, s3 – s5.

Complete papers published in conference proceedings

1) Le T.B., Garcia G.J.M. (2018) Simulating airway collapse in obstructive sleep apnea using fluid structureinteraction methodologies. Proceedings of the 2018 Design of Medical Devices Conference, Minneapolis,Minnesota, USA, April 9–12, 2018. Paper No. DMD2018-6818, pages 1-4. DOI:10.1115/DMD2018-6818

2) Garcia G.J.M., Kimbell J.S., Barnum B.T., Cragun M. (2008) Expanding engineering analysis tools tobiomedical applications: Using an example of nasal airflow in patients with septal deviations. NAFEMS2008.

3) Tewksbury E.W., Garcia G.J.M., Kimbell J.S., Wong B.A. (2008) Inter-human variability in nasal filtration ofinhaled particles among nasal replicas of four healthy individuals. Respiratory Drug Delivery 2008, 767-770.

4) Garcia G.J.M., Mitchell G., Bailie N., Thornhill D., Watterson J., Kimbell J.S. (2007) Visualization of nasalairflow patterns in a patient affected with atrophic rhinitis using particle image velocimetry. Journal ofPhysics: Conference Series 85, 012032.

5) Garcia G.J.M., da Silva J.K.L. (2003) Dimensões dos ossos longos dos mamíferos. X Congresso Brasileiro deBiomecânica, Ouro Preto, Brazil, June 3-6, 2003.

Publication Metrics

Date of access: July 21, 2020

1 – Scopus

h-index: 22

Total number of citations: 1,292

https://www.scopus.com/authid/detail.uri?authorId=7202754943

2 – ResearcherID

h-index: 21


http://www.researcherid.com/rid/J-9555-2013

3 – Google Scholar

h-index: 24


https://scholar.google.com/citations?hl=en&user=lIgNRwsAAAAJ

https://www.scopus.com/authid/detail.uri?authorId=7202754943

http://www.researcherid.com/rid/J-9555-2013

https://scholar.google.com/citations?hl=en&user=lIgNRwsAAAAJ

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TEACHING EXPERIENCE

Marquette University, Milwaukee, USA

Undergraduate courses

Transport Phenomena is a 3-credit course with 3 classes a week. Each class is 50-min long. The course had 3 exams and 6 graded homework assignments. Graduate students also completed a project.

The course evaluation below is the median score that students in the class entered for the question “How was this class as a whole?” in an anonymous, electronic survey that students fill out at the end of each semester. The scale is Excellent=6, Very Good=5, Good=4, Fair=3, Poor=2, and Very Poor=1.

2018/Spring – Transport Phenomena (BIEN 4400/5400). (Enrollment = 49 students.)

(Course evaluation by the students: 4.8 out of 6.0)

2019/Spring – Transport Phenomena (BIEN 4400/5400). (Enrollment = 52 students.)


2019/Fall – Transport Phenomena (BIEN 4400/5400). (Enrollment = 44 students.)


Graduate courses

This was a 3-credit course with 2 classes a week. Each class was 75-min long. The course had 3 exams, 1 project, and 1 oral presentation.

2017/Spring – Fluid Mechanics of Respiratory Airflow and Drug Delivery (BIEN 6391). (Enrollment = 7 students.)

Senior design

During their senior year, biomedical engineering students conduct a year-long project to design and fabricate a prototype. Projects are sponsored by industry or faculty. My role as the Faculty Advisor is to supervise the team’s progress through 1 to 2 meetings per month, point them to resources, provide training on effective oral presentations, and grade their final report and oral presentation at the end of each semester.

2016/Fall & 2017/Spring – Team B5 (5 students)

Project: Heart Picture Illustrator

Sponsor: Siemens Healthineers


Project: ECG Simulator

Sponsor: Mortara Instrument Inc.


Project: Laryngeal Nerve Monitoring in Infants to Prevent Vocal Cord Paralysis During Surgery

Sponsor: Dr. Thomas Robey, Department of Otolaryngology at MCW


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Project: Non-Invasive Core Body Temperature Sensor

Sponsor: Dr. Tucker Woodson, Department of Otolaryngology at MCW

Universidade Federal de São João Del Rei, Brazil

These undergraduate courses had 2 classes a week. Each class was 100-min long. Each course 4 exams.

2012/1 – Mechanics – Fundamentals of Physics. (Enrollment = 55 students.)

2012/1 – Linear Algebra and Analytic Geometry. (Enrollment = 2 classes of 55 students each.)

Universidade Federal de Minas Gerais, Brazil

These undergraduate courses had 2 classes a week. Each class was 100-min long. Each course had 4 exams.

2011/2 – Biophysics for pharmacy and biology students. (Enrollment = 50 students.)

2011/1 – Electromagnetism for engineering students. (Enrollment = 50 students.)

This laboratory course had 2 classes a week. Each class was 120-min long. Each team of 2 students wrote a report that was graded after each class.

2001/2 – Thermodynamics and Mechanics Laboratory. (Enrollment = 40 students.)

SERVICE

International Conference Organizing Committee

I was part of a 4-member committee that organized this international meeting. This 1-day conference had approximately 50 participants.

2019 World Congress for the Society for Computational Fluid Dynamics of the Nose & Airway (SCONA), Chicago, IL, USA, June 5, 2019.

Dissertation / Thesis Committees

Doctor in Philosophy (PhD) committees

1. Atefeh Razavi. Patient-specific modeling of altered coronary artery hemodynamics to predictmorbidity in patients with anomalous origin of a coronary artery. Department of BiomedicalEngineering, Marquette University and The Medical College of Wisconsin. Mentor: John LaDisa,PhD. April 2, 2020.

2. Milad Kiaee Darunkola. Simulation of Spray Deposition in Adults Nasal Airway. Department ofMechanical Engineering, University of Alberta. Mentor: Warren Finlay, PhD. September 12, 2018.

3. Giancarlo Cherobin. Rhinomanometry performed via computational fluid dynamics (in Portuguese).Department of Otolaryngology, Universidade de Sao Paulo. Mentors: Richard Voegels, MD andGuilherme Garcia, PhD. December 5, 2017.

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Master in Science (MSc) committees

1. John Venn. Immersive Visualization in Biomedical Computational Fluid Dynamics and DidacticTeaching and Learning. Department of Biomedical Engineering, Marquette University & TheMedical College of Wisconsin. Mentor: John LaDisa, PhD. April 6, 2018.

2. Kevin Garman. Collapsible Silicone Tubes: An in vitro model for tracheal traction. Department ofBiomedical Engineering, Marquette University & The Medical College of Wisconsin. Mentor:Guilherme Garcia. July 10, 2017.

3. Paul Eserkaln. Sensitivity Analysis of Geometry Changes in the Simulation of Basilar Aneurysms.Department of Mechanical Engineering, University of Wisconsin-Milwaukee. Mentor: Vitaliy Rayz,PhD. November 18, 2016.

Dissertation Project Proposal committees

1. Atefeh Razavi. Development and application of procedures to increase the realism of simulationsfor congenital and acquired coronary artery diseases. Department of Biomedical Engineering,Marquette University & The Medical College of Wisconsin. Mentor: John LaDisa, PhD. December13, 2018.

2. Nazanin Maani. A two-scale approach for CFD modeling of endovascular Chemofilter device.Department of Mechanical Engineering, University of Wisconsin-Milwaukee. Mentor: Vitaliy Rayz,PhD. May 3, 2016.

Local Committees

2013-Present Resident Research Committee, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin

This committee meets once a year to review 3 otolaryngology resident research projects.

2016-Present Research Committee, Department of Biomedical Engineering, Marquette University & the Medical College of Wisconsin

This committee meets once a month to foster research in the BME department.

2019-Present Faculty Career Development Committee, Medical College of Wisconsin

This committee meets once a month to develop opportunities for faculty career development, including reviewing applications to the Faculty Vitality Award.

Seminar Organizer

I organized 1 seminar/month (approximately 12 per year) in the following roles.

2011 Biophysics seminar series, Physics Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

2014 Biomedical Engineering Seminar Series at the Medical College of Wisconsin

Judge/reviewer at local poster sessions

10/2011 Reviewer, Poster contest, Undergraduate students, Physics department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

09/23/2013 Reviewer, Poster contest, Medical Student Summer Research Program 2013


07/30/2015 Judge, Oral presentations, Undergraduate Summer Program 2015

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12/2015 Honors in Research award (2 theses reviewed)



11/8/2017 Reviewer, Poster contest, Graduate School Research Poster Session 2017



Reviewer for the following peer-reviewed journals (records since 2013)

Review of revised manuscripts are not included below. This is a list of first submissions only.

2013 (n = 12 articles reviewed)

Journal of Applied Physiology (n=1), Laryngoscope (n=1), Acta Oto-Laryngologica (n=2), Aerosol Science and Technology (n=1), Allergy & Rhinology (n=1), Annals of Otology Rhinology and Laryngology (n=1), Asian Biomedicine (n=1), Auris, Nasus, Larynx (n=1), General Physiology & Biophysics (n=1), International Journal for Numerical Methods in Biomedical Engineering (n=1), JAMA Facial Plastic Surgery (n=1).


Journal of Biomechanics (n=1), Journal of the Royal Society Interface (n=1), Cleft Palate-Craniofacial Journal (n=1), JAMA Facial Plastic Surgery (n=1), PLOS ONE (n=2), Respiratory Physiology and Neurobiology (n=1), Transactions on Biomedical Engineering (n=1).


Journal of Applied Physiology (n=2), Journal of Biomechanics (n=1), Acta Oto-Laryngologica (n=1), Computers in Biology and Medicine (n=1).


Journal of Applied Physiology (n=1), Journal of Biomechanics (n=1), Laryngoscope (n=1), Biocybernetics and Biomedical Engineeering (n=1), Brazilian Journal of Medical and Biological Research (n=1), Computers in Biology and Medicine (n=1), JAMA Facial Plastic Surgery (n=1), Molecular Biology of the Cell (n=1), Respiratory Physiology & Neurobiology (n=1).


Biophysical Journal (n=1), Computational and Mathematical Methods in Medicine (n=1), International Journal for Pediatric Otolaryngology (n=1), JAMA Facial Plastic Surgery (n=1), Journal of Applied Physiology (n=1), Journal of Biomechanics (n=1), Laryngoscope (n=1), Particle and Fiber Toxicology (n=1), Pharmaceutical Research (n=1).


Journal of Applied Physiology (n=2), Journal of Biomechanics (n=2), Journal of the Royal Society Interface (n=1), SLEEP (n=1), Laryngoscope (n=2), Clinical Otolaryngology (n=2), Computers in Biology and Medicine (n=1), International Journal for Numerical Methods in Biomedical Engineering (n=2), Scientific Reports (n=1).


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Acta Oto-Laryngologica (n=1), Aerosol Science and Technology (n=1), Circulation: Heart Failure (n=1), International Forum of Allergy and Rhinology (n=2), International Journal of Computer Assisted Radiology and Surgery (n=2), Journal of Applied Physiology (n=2), Journal of Biomechanics (n=1), Journal of Clinical Sleep Medicine (n=1), Journal of the Royal Society Interface (n=1), Journal of Thermal Biology (n=1), Laryngoscope (n=3), Medical Devices Evidence and Research (n=1), Orthodontics and Craniofacial Research (n=1), Proceedings of the Wisconsin Space Conference (n=2), Scientific Reports (n=1).

2020 (n = 14 article reviewed)

Journal of Applied Physiology (n=2), Laryngoscope (n=4), International Journal of Computer Assisted Radiology

and Surgery (n=2), International Journal for Pediatric Otolaryngology (n=1), Journal of Aerosol Science (n=1),

Journal of Clinical Sleep Medicine (n=1), Lasers in Surgery and Medicine (n=1), Respiratory Physiology and

Neurobiology (n=2).

TRAINEES / STUDENTS MENTORED

High School Students

Students in the Students Understanding Principles of Research Education through Medicine, Engineering, and Science (SUPREMES) program at MCW work 6 to 8 hours a week for 18 weeks. At the end of the program, they present a poster and write a manuscript summarizing their research results.

Celena Wirth (01/2018 - 05/2018), SUPREMES program.

Anthony Segedi (01/2019 - 05/2019), SUPREMES program.

The following students were mentored outside an official program.

Sean Flanary (06/2015 - 07/2015). This student worked 40 hours/week for 4 weeks to create 3-dimensional models of the (1) nose and paranasal sinuses, and (2) the trachea, larynx and surrounding soft tissues and bones to be used as an educational tool.

Hye Sung Jung (08/2018 - 03/2019). This student worked mostly from home to develop a computer code. We held monthly meetings to collect data in the lab and analyze the data with his code. He presented a poster at the 2019 Badger State Science and Engineer Fair.

Undergraduate Students

Students in summer programs at The Medical College of Wisconsin work 40 hours a week for 10 weeks. At the end of the program, they present a seminar summarizing their research results.

Andrew Summers (05/2013 - 08/2013)

Andrew Summers (05/2014 - 08/2014)

Brianna Donaldson-Morton (05/2018 - 08/2018)

The following student was mentored outside an official program.

Benjamin Hariri (02/2014 - 06/2014). Research resulted in 2 publications in peer-reviewed journals. Benjamin had a degree in finances and was interested in applying to medical school. He worked 40/hours a week for 5 months. He was involved in several research projects in my lab that resulted in 2 manuscripts in peer-reviewed journals. He is now a medical student at George Washington University.

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Master in Science Students

Tauanne Dias Amarante (02/2011 - 01/2012), Universidade Federal de Minas Gerais, Thesis: Computational model for the regulation of extracellular nucleotides in the airway surface liquid lining the human respiratory tract. Research resulted in 1 publication in a peer-reviewed journal.

Kevin Garman (09/2015 – 09/2017), Marquette University, Thesis: Collapsible silicone tubes: An in vitro model for tracheal traction.

PhD Student

Giancarlo Cherobin, M.D. (08/2011 – 12/2017), Universidade de Sao Paulo, Brazil. Dissertation: Rhinomanometry performed via computational fluid dynamics. Research resulted in 1 publication in a peer-reviewed journal so far. (We have data for 1 more publication.)

Medical Student Summer Program (MSSRP)

Medical students in the MSSRP program work 40 hours a week for 8 to 11 weeks. At the end of the program, they present a poster summarizing their research results.

Ryan Bailey (05/2014 - 08/2014)

Gabriel Oland (05/2014 - 07/2014)

Courtney Gaberino (06/2015 - 08/2015)

Jaroslaw Janczy (06/2016 - 08/2016)

Emily Lin (06/2016 - 08/2016)

Medical Students

Medical students in the Physician-Scientist Pathway at MCW must complete a research project during their M1 to M3 years. At the end of the program, the student must write a manuscript summarizing their research results.

Anupriya Dayal (11/2013 - 06/2016). Research resulted in 1 publication in a peer-reviewed journal.

Gabriel Oland (11/2013 - 06/2015)

Ryan Bailey (11/2013 - 06/2016). Research resulted in 1 publication in a peer-reviewed journal.

Courtney Gaberino (11/2014 - 06/2017). Research resulted in 1 publication in a peer-reviewed journal.

Emily Lin (11/2015 - 06/2018). Research resulted in 2 publications in peer-reviewed journals.

Jaroslaw Janczy (09/2015 - 06/2018). Research rotation is expected to result in 1 publication in a peer-reviewed journal.

Jacob Thurston (08/2016 - 06/2018). Research rotation is expected to result in 1 publication in a peer-reviewed journal.

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The following medical students were mentored outside an official program.

Thomas Leschke (08/2013 - 06/2015).

Anthony Prisco, M.D./Ph.D student (05/2014 - 06/2016). Research resulted in 1 publication in a peer-reviewed journal

Residents

Otolaryngology residents at MCW perform a 4-month research rotation, which is divided into 3 months at 100% effort plus 2 months at 50% effort. The project is proposed at the end of their PGY1 year, while the research rotation occurs during their PGY3 year.

Corbin Sullivan (10/2012 - 03/2013). Research rotation resulted in 2 publications in peer-reviewed journals.

Ruchin Patel (11/2013 - 03/2014). Research rotation resulted in 2 publications in peer-reviewed journals.

Kevin Casey (11/2015 - 03/2016). Research rotation resulted in 2 publications in peer-reviewed journals.

Derek Vanhille (07/2016 - 11/2016). Research rotation resulted in 1 publication in a peer-reviewed journal.

David Campbell (08/2018 - 12/2018). Research rotation resulted in 1 publication in a peer-reviewed journal.

Hillary Newsome (12/2018 – 4/2019). Research rotation is expected to result in 2 publications in peer-reviewed journals (1 paper is published, 1 draft).

Postdoctoral Fellows

Azadeh Borojeni (04/2015 – 03/2017). Research resulted in 5 publications in peer reviewed journals.

Masoud Moghaddam (04/2017 – 06/2019). Research is expected to result in 6 publications in peer-reviewed journals (2 papers published, 2 currently under review, 2 drafts).

Trung Le (05/2017 – 08/2018). Research is expected to result in 3 publications in peer-reviewed journals (1 paper is published, 2 drafts).

Yongwoon Jung (06/2019 – 12/2019). Research is expected to result in 1 publication in a peer-reviewed journal.

Amin Zarandi (09/2019 – current)

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CONFERENCES Oral Presentations

1. Second World Congress for the Society for Computational Fluid Dynamics of the Nose and Airway (SCONA), Chicago, IL, USA, June 5, 2019, Diagnosis of nasal obstruction via CFD, Garcia G.J.M.

2. First World Congress for the Society for Computational Fluid Dynamics of the Nose and Airway (SCONA), London, UK, April 22, 2018, Correlating CFD with objective clinical testing and physical models, Garcia G.J.M.

3. First World Congress for the Society for Computational Fluid Dynamics of the Nose and Airway (SCONA), London, UK, April 22, 2018, Interpreting simulation results, Garcia G.J.M.

4. 36th American Association for Aerosol Research (AAAR) Annual Conference, Raleigh, NC, USA, October 16-20, 2017, Quantifying inter-individual variability in nasal filtration of nebulized micron-sized particles as a function of nasal anatomy using computational fluid dynamics, Borojeni A.A.T., Rhee J.S., Garcia G.J.M.

5. 2016 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, San Diego, CA, USA, October 18-21, 2016, Effects of mucosal decongestion on nasal aerodynamics, Garcia G.J.M., Cherobin G., Casey K.P., Borojeni A.A.T., Koenig L.J., Voegels R., Rhee J.S.

6. Modeling Laryngeal Biology, Madison, WI, USA, July 7, 2016. Computational Fluid Dynamics Analysis of Laryngeal Particle Deposition from Inhaled Corticosteroids, Garcia G.J.M., Leschke T.M., Blumin J.H., Bock J.M.

7. 26th Congress of the European Rhinologic Society, Stockholm, Sweden, July 3-7, 2016. The relationship between nasal resistance to airflow and the airspace minimal cross-sectional area, Garcia G.J.M., Hariri B.M., Patel R.G., Rhee J.S.

8. IEEE USA Annual Meeting 2015 & 36th Great Lakes Biomedical Conference, Milwaukee, WI, USA, May 14-17, 2015. Experimental validation of nasal airflow computer simulations using patient-specific models. Garcia G.J.M.

9. American Physical Society 67th Annual Meeting Division of Fluid Dynamics, San Francisco, CA, USA, Nov 23-25, 2014. Perception of Better Nasal Patency Correlates with Increased Mucosal Cooling after Surgery for Nasal Obstruction. Garcia G.J.M., Sullivan C.D., Frank-Ito D.O., Kimbell J.S., Rhee J.S.

10. XXXV National Meeting of Condensed Matter Physics (In Portuguese), Águas de Lindóia, SP, Brazil, May 14-18, 2012. Filtration of inhaled particles and toxic gases in the human nasal cavity. Garcia G.J.M., Schroeter J.D., Kimbell J.S.

11. Physics Meeting 2011 (In Portuguese), Foz do Iguaçu, PR, Brazil June 5-10, 2011. Septal deviation and nasal resistance: An investigation using virtual surgery and computational fluid dynamics. Garcia G.J.M., Rhee J.S., Senior B.A., Kimbell J.S.

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12. IV Rhinology 2008, São Paulo, SP, Brazil, May 22-24, 2008. Improving nasal surgery through bioengineering. Garcia G.J.M., Kimbell J.S.

13. 38th Brazilian Otolaryngology Conference (In Portuguese), Salvador, BA, Brazil, November 27 to December 1, 2006. Atrophic rhinitis: A computational study of air conditioning in the nasal cavity. Garcia G.J.M., Bailie N., Martins D.A., Kimbell J.S.

14. 37th Brazilian Otolaryngology Conference (In Portuguese), Fortaleza, CE, Brazil, November 16-20, 2004. Airflow in the human nose: What is known and future perspectives. Garcia G.J.M., Dickman R., Vieira M.N., Martins D.A.

15. LAWNP03 (VIII Latin American Workshop on Non-linear Physics), Salvador, BA, Brazil, September 28 to October 3, 2003. On the thresholds, probabilitiy densities and critical exponents of Bak-Sneppen-like models. Garcia G.J.M., Dickman R.

16. X Brazilian Biomechanics Conference (In Portuguese), Ouro Preto, MG, Brazil, June 3-6, 2003. A model for the scaling of mammalian long bones. Garcia G.J.M., da Silva J.K.L.

17. I Meeting of physics graduate students and post-docs (In Portuguese), UFMG, Belo Horizonte, MG,

Brazil, August 27-29, 2003. On the universality class of the Bak-Sneppen model. Garcia G.J.M., Dickman R.

18. I National meeting of engineering and mathematical sciences students (In Portuguese), UFSC, Florianópolis, SC, Brazil, April 18-20, 1998. Fractal Surfaces. Oliveira A.N., Maia D.F., Engellender G.A., Garcia G.J.M., Lima G.H.R.A., Lemos H.C.F., Neto J.C., Moreira J.M., Martins P.H.L., Paulinyi Z.

Poster Presentations

1. 2020 American Thoracic Society (ATS) International Conference, Philadelphia, PA, USA, May 15-20, 2020. A novel biomechanical model of upper airway collapse in obstructive sleep apnea: An improvement to the classical Starling resistor model. Garcia G.J.M., Woodson B.T. (Abstract accepted)

2. 2019 American Thoracic Society (ATS) International Conference, Dallas, TX, USA, May 17-22, 2019. Impact of oral appliances on the pharyngeal closing pressure in patients with obstructive sleep apnea. Garcia G.J.M., Campbell D., Bailey R.S., Welzig C.M., Woodson B.T.

3. 2019 American Thoracic Society (ATS) International Conference, Dallas, TX, USA, May 17-22, 2019. Fluid-structure interaction simulations and experiments of airflow limitation in models of obstructive sleep apnea. Garcia G.J.M., Moghaddam M.G., Le T.B.

4. 27th Annual North American Cystic Fibrosis Conference, Salt Lake City, UT, USA, October 17-19, 2013. Effects of airway surface liquid height on the kinetics of extracellular nucleotides. Garcia G.J.M., Amarante T.D , da Silva J.K.L.

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5. 1st Brazilian Workshop on Cellular Electrophysiology (In Portuguese), Belo Horizonte, MG, Brazil, April 26-28, 2012. Computational model for the regulation of extracellular nucleotides in the airway surface liquid lining the human respiratory tract. Amarante T.D., Garcia G.J.M., da Silva J.K.L.

6. 24th Annual North American Cystic Fibrosis Conference, Baltimore, MA, USA, October 21-23, 2010. A

model of water and ion transport in airway epithelia: CF vs. Normal cells. Garcia G.J.M., Boucher R.C., Elston T.C.

7. Respiratory Drug Delivery 2008, Scottsdale, AZ, USA, May 11-15, 2008. Inter-human variability in nasal filtration of inhaled particles among nasal replicas of four healthy individuals.Tewksbury E.W., Garcia G.J.M., Kimbell J.S., Wong B.A.

8. Society of Toxicology (SOT) 47th Annual Meeting, Seattle, WA, USA, March 16-20, 2008. Nanoparticle deposition in the rat nasal cavity: prediction of dose to the olfactory epithelium. Garcia G.J.M., Nazridoust K., Kimbell J.S.

9. 53rd Annual Meeting of the American Rhinologic Society, Washington, DC, USA, September 15, 2007. Can nasal symptoms be explained by abnormal airflow patterns in atrophic rhinitis? Garcia G.J.M., Mitchell G., Martins D.A., Bailie N., Bernard E., Watterson J., Kimbell J.S.

10. International Science Forum on Computational Toxicology, Research Triangle Park, NC, USA, May 21-23, 2007. (a) Ozone Uptake in the Nasal Passages of the Infant Rhesus Monkey: Predicting Lesion Location with Computational Fluid Dynamics. Garcia G.J.M., Carey S.A., Taylor A.B., Borhan A., Ultman J.S., Harkema J.R., Kimbell J.S. (b) Nasal Dosimetry in Childhood: Construction of Anatomically-Accurate Models. Kimbell J.S., Garcia G.J.M., Stanek J.J., Foureman G.L.

11. Society of Toxicology (SOT) 46th Annual Meeting, Charlotte, NC, USA, March 25-29, 2007. Deposition efficiency of inhaled particles from 30 nm to 10 µm in different individual human nasal replicas. Wong B.A., Tewksbury E.W., Garcia G.J.M., Kimbell J.S.

12. 38th Brazilian Otolaryngology Conference (In Portuguese), Salvador, BA, Brazil, November 27 to December 1, 2006. How efficiently does an atrophic nose filter the air? Garcia G.J.M., Tewksbury E.W., Wong B.A., Kimbell J.S.

13. American Thoracic Society 2006 International Conference, San Diego, CA, USA, May 19-24, 2006. (a) Investigation of atrophic rhinitis in humans using computational fluid dynamics models of the nasal passages. Garcia G.J.M., Martins D.A., Bailie N., Kimbell J.S. (b) Use of stereolithography to confirm computational fluid dynamics studies of nasal airflow patterns in atrophic rhinitis patient. Kimbell J.S., Kalisak D.L., Garcia G.J.M.

14. XXVII National Meeting of Condensed Matter Physics (In Portuguese), Poços de Caldas, MG, Brazil, May 4-8, 2004. The Bak-Sneppen model with absorbing states. Garcia G.J.M., Dickman R.

15. XXVI National Meeting of Condensed Matter Physics (In Portuguese), Caxambu, MG, Brazil, May 6-10, 2003. (a) Functional equations in modified Bak-Sneppen models. Garcia G.J.M., Dickman R. (b) Critical exponents for anisotropic Bak-Sneppen models. Garcia G.J.M., Dickman R. (c) A model for the scaling of mammalian long bones. Garcia G.J.M., da Silva J.K.L.

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16. III Week of graduate students (In Portuguese), UFMG, Belo Horizonte, MG, Brazil, February 21-23,

2002. Scaling laws in biology – The connection between bone allometry, muscle cross-sectional area and locomotion. Garcia G.J.M., da Silva J.K.L.

17. XXV National Meeting of Condensed Matter Physics (In Portuguese), Caxambu, MG, Brazil, May 7-11, 2002. Scaling in biology – Bone allometry. Garcia G.J.M., da Silva J.K.L.

18. VII Week of undergraduate research (In Portuguese), UFMG, Belo Horizonte, MG, Brazil, October 26-31, 1998. (a) Writing a book for school children on crystal growth, Garcia G.J.M., Balzuweit K. (b) Fractals: creation of teaching material. Oliveira A.N., Maia D.F., Engellender G.A., Garcia G.J.M., Lima G.H.R.A., Lemos H.C.F., Neto J.C., Moreira J.M., Martins P.H.L., Paulinyi Z.

Abstracts presented by co-authors (students, collaborators)

1. 2019 American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) Annual Meeting, San Diego, CA, USA, October 3-5, 2019. Quantifying Airflow Limitation Due to Dynamic Lateral Nasal Wall Collapse. Newsome H., Moghaddam M.G., Rhee J.S., Garcia G.J.M.

2. 2019 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, New Orleans, LA, USA, September 15-18, 2019. Physiologic Metrics of Pharyngeal Collapsibility Versus DISE. Woodson B.T., Garcia G.J.M.

3. 2019 World Congress of the Society for Computational Fluid Dynamics of the Nose & Airway (SCONA), Chicago, IL, USA, June 5, 2019. Exploring nasal spray positioning to improve targeted drug delivery. Basu S., Garcia G.J.M., Farzal Z., Frank-Ito D.O., Kimbell J.S.

4. 2019 World Congress of the Society for Computational Fluid Dynamics of the Nose & Airway (SCONA), Chicago, IL, USA, June 5, 2019. Virtual septoplasty using computational fluid dynamics. Moghaddam M.G., Garcia G.J.M., Frank-Ito D.O., Kimbell J.S., Rhee J.S.

5. 2019 World Congress of the Society for Computational Fluid Dynamics of the Nose & Airway (SCONA), Chicago, IL, USA, June 5, 2019. Quantifying Airflow Limitation Due to Dynamic Lateral Nasal Wall Collapse. Newsome H., Moghaddam M.G., Rhee J.S., Garcia G.J.M.

6. 2019 10th International Surgical Sleep Society Meeting, New York, NY, USA, May 10-11, 2019. Impact of oral appliances on the pharyngeal closing pressure in patients with obstructive sleep apnea. Garcia G.J.M., Campbell D., Bailey R.S., Welzig C.M., Woodson B.T.

7. 2019 22nd Annual Meeting of the Triological Society at the Combined Otolaryngology Spring Meetings (COSM), Austin, TX, USA, May 1-5, 2019. Bernoulli Obstruction Theory: A Possible Explanation for Septoplasty Failure Rates. Campbell D.A., Moghaddam M.Gh., Rhee J.S., Garcia G.J.M.

8. 2019 American Society of Pediatric Otolaryngology (ASPO) at the Combined Otolaryngology Spring Meetings (COSM), Austin, TX, USA, May 1-5, 2019. Upper airway resistance in healthy vs. cleft lip and palate children. Thurston J.S., Moghaddam M.Gh., Kimbell J.S., Zdanski C., McCormick M., Garcia G.J.M.

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9. 2018 Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, October 17-20, 2018. Fluid-

Structure Interaction Simulations and Experiments of Airflow Limitation in Models of Obstructive Sleep Apnea. Garcia G.J.M., Moghaddam M.G., Le T.B.

10. 2018 International Mechanical Engineering Congress and Exposition (IMECE), Pittsburgh, PA, USA, November 9-15, 2018. Virtual Septoplasty using Computational Fluid Dynamics. Moghaddam M.G., Kimbell J.S., Frank-Ito D.O., Rhee J.S. Garcia G.J.M.

11. 62nd Biophysical Society Annual Meeting, San Francisco, CA, USA, February 17-21, 2018. Modeling Mechanisms of Cardiac L-type Ca2+ Channel Function: Regulations by Voltage, Nano-Domain Ca2+, and Isoflurane. Manhas N., Camara A.K.S., Garcia G.J.M., Dash R.K.

12. 2018 Design of Medical Devices Conference, Minneapolis, MN, USA, April 9–12, 2018. Simulating airway collapse in obstructive sleep apnea using fluid structure interaction methodologies. Le T.B., Garcia G.J.M.

13. 2017 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, Chicago, IL, September 10-13, 2017, Normal ranges of nasal airflow variables in healthy adults, Borojeni A.A.T., Garcia G.J.M., Frank-Ito D.O., Kimbell J.S., Laud P.W., Koenig L.J., Rhee J.S.

14. 2017 American Thoracic Society (ATS) International Conference, Washington, DC, USA, May 19-24, 2017. Anatomical Factors Influencing the Collapsing Pressure in Obstructive Sleep Apnea. Janczy J., Woodson B.T., Garcia G.J.M.

15. 2017 American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) meeting at the Combined Otolaryngology Spring Meetings (COSM), San Diego, CA, USA, April 26-30, 2017. A pilot study evaluating surgeon experience with virtual surgery modeling for nasal airway obstruction. Vanhille D.L., Garcia G.J.M., Pawar S.S., Borojeni A.A.T., Frank-Ito D.O., Kimbell J.S., Rhee J.S.

16. 2017 American Broncho-Esophagological Association (ABEA) meeting at the Combined Otolaryngology Spring Meetings (COSM), San Diego, CA, USA, April 26-30, 2017. Computational fluid dynamics study of airflow limitation associated with subglottic stenosis. Lin E.L., Bock J.M., Zdanski C., Kimbell J.S., Garcia G.J.M.

17. 2016 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, San Diego, CA, USA, October 18-21, 2016. Collapsible silicone tubes: an in vitro model for tracheal traction. Garman K., Woodson B.T., Garcia G.J.M.

18. 2016 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, San Diego, CA, USA, October 18-21, 2016. Intranasal airflow distribution and perception of nasal patency. Casey K.P., Garcia G.J.M., Borojeni A.A.T., Koenig L.J., Rhee J.S.

19. The 2016 Fall Voice Conference, Scottsdale, AZ, USA, October 13-15, 2016. Use of computational fluid dynamics to predict glottic deposition of inhaled corticosteroids in the setting of vocal fold granulomas. Perkins E., Kimbell J.S., Garcia G.J.M., Buckmire R., Shah R.

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20. Summer Biomechanics, Bioengineering, and Biotransport Conference, National Harbor, MD, USA, June 29 to July 2, 2016. Apical inflow angulation and left ventricle size may impact LVAD thrombosis risk. Chivukula V.K., McGah P., Prisco A.R., Beckman J.A., Garcia G.J.M., Mahr C., Aliseda A.

21. 2016 American Rhinologic Society (ARS) meeting at the Combined Otolaryngology Spring Meetings (COSM), Chicago, IL, USA, May 19-20, 2016. Comparison of nasal airflow simulations in healthy nasal cavity models built from cone beam vs. conventional computed tomography. Borojeni A.A.T., Frank-Ito D.O., Kimbell J.S., Koenig L.J., Garcia G.J.M., Rhee J.S.

22. 2016 American Rhinologic Society (ARS) meeting at the Combined Otolaryngology Spring Meetings (COSM), Chicago, IL, USA, May 19-20, 2016. Nasal mucosa temperature in healthy individuals and its correlation to subjective nasal patency. Bailey R.S., Casey K., Pawar S.S., Garcia G.J.M.

23. 2016 American Rhinologic Society (ARS) meeting at the Combined Otolaryngology Spring Meetings (COSM), Chicago, IL, USA, May 19-20, 2016. Estimates of nasal airflow at the nasal cycle mid-point improve the correlation between objective and subjective measures of nasal patency, Gaberino C., Rhee J.S., Garcia G.J.M.

24. 60th Biophysical Society Annual Meeting, Los Angeles, CA, USA, February 27 to March 2, 2016. Modeling the Effects of Volatile Anesthetics on L-type Ca2+ Channels and Ca2+ Induced Ca2+ Release in Cardiac Myocytes. Manhas N., Garcia G.J.M., Pannala V., Kwok W.-M., Camara A.K.S., Dash R.K.

25. 2015 American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, Dallas, TX, USA, September 27-30, 2015. Impact of Middle vs. Inferior Turbinectomy on Nasal Aerodynamics, Dayal A., Rhee J.S., Garcia G.J.M.

26. 2015 Annual Meeting of the American Laryngological Association at the Combined Otolaryngology Spring Meetings (COSM), Boston, MA, April 22-23, 2015. Computational fluid dynamic analysis of laryngeal particle deposition from inhaled corticosteroids, Leschke T.M., Garcia G.J.M., Bock J.M..

27. 2015 American Society of Pediatric Otolaryngology Spring Meeting at the Combined Otolaryngology Spring Meetings (COSM), Boston, MA, April 24-26, 2015. Upper airway reconstruction using anatomic optical coherence tomography: Effects of airway bend on airflow resistance, Kimbell J.S., Garcia G.J.M., Frank-Ito D.O., Lazarow F.B., Protsenko D.E., Chen Z., Wong B.J..

28. American Academy of Otolaryngology Annual Meeting 2014, Orlando, FL, USA, September 21-24 2014. A method to quantify the confounding effect of the nasal cycle on nasal airway obstruction, Patel R., Garcia G.J.M., Frank-Ito D.O., Kimbell J.S., Rhee J.S..

29. 2014 American Rhinologic Society Spring Meeting at the Combined Otolaryngology Spring Meetings (COSM), Las Vegas, NV, May 14-18, 2014. Computational streamline rhinometry: A novel method to evaluate nasal anatomy, Garcia G.J.M., Patel R., Frank-Ito D.O., Kimbell J.S., Rhee J.S..

30. 2014 Meeting of the Society for Neuro Oncology, Miami, FL, November 11-13, 2014. Gamma Knife Radiosurgery for Acoustic Neuroma: Assessment of Quality and Outcomes, Straza M., Garcia G.J.M., Hariri B., Patel R., Albano K., Schultz C., Friedland D., Bovi J..

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31. American Academy of Otolaryngology Annual Meeting 2013, Vancouver, Canada, September 29 - October 2, 2013. Perception of nasal patency correlates with changes in mucosal cooling after surgery for nasal obstruction. Sullivan C.D., Garcia G.J.M., Frank D.O., Kimbell J.S., Rhee J.S..

32. X Meeting 2012, Campinas, SP, Brazil, October 14-17, 2012. Model for the regulation of extracellular nucleotides in airway surface liquid. Amarante T.D., da Silva J.K.L., Garcia G.J.M.

33. Society of Toxicology (SOT) 51st Annual Meeting, San Francisco, CA, USA, March 11-15, 2012. Correlation between computer-derived ozone flux and ozone-induced injury in the nasal airways of infant rhesus monkeys. Carey S.A, Garcia G.J.M., Postlethwait E.M., Harkema J.R., Kimbell J.S.

34. 2007 Society for Risk Analysis Annual Meeting, San Antonio, TX, USA, December 9-12, 2007. Age-Related Intra-Human Variability in Nasal Dosimetry. Kimbell J.S., Garcia G.J.M., Stanek J., Foureman G.L.

35. International Society for Aerosols in Medicine (ISAM), 16th International Conference, Tours, France, June 16-20, 2007. Analysis of particle deposition in the human nasal cavity with application to intranasal drug delivery. Schroeter J.D., Garcia G.J.M., Kimbell J.S.

36. American Thoracic Society 2007 International Conference, San Francisco, CA, USA, May 18-23, 2007. Use of magnetic resonance imaging, light microscopy, and three-dimensional reconstruction in epithelial mapping of the nasal airways of infant monkeys. Carey S.A., Garcia G.J.M., Minard K.R., Einstein D.R., Ballinger C.A., Wagner J.G., Plopper C.G., Corley R.A., Postlethwait E.M., Kimbell J.S., Harkema J.R.

37. Third International Conference on Optical and Laser Diagnostics (ICOLAD 2007), London, UK, May 22-25, 2007. Visualization of nasal airflow patterns in a patient affected with atrophic rhinitis using particle image velocimetry. Garcia G.J.M., Mitchell G., Bailie N., Bernard E., Watterson J., Kimbell J.S.

38. XXVIII National Meeting of Condensed Matter Physics (In Portuguese), Santos, SP, Brazil, May 10-14 , 2005. (a) Transitions to an absorbing state with extremal dynamics. Dickman R., Garcia G.J.M. (b) The scaling of the maximum metabolic rates of mammals and birds. Barbosa L.A., Garcia G.J.M., da Silva J.K.L.

INVITED TALKS

1. 2019 Design of Medical Devices Conference, Minneapolis, MN, USA, April 16-18, 2019. Seminar title: Penetration of nasal sprays beyond the nasal valve: Physical principles to maximize nasal drug delivery.

2. Conversations with Scientists, Advancing a Healthier Wisconsin, Milwaukee, WI, USA, April 23, 2019. Seminar title: The physics of obstructive sleep apnea.

3. Grand Rounds, Department of Otolaryngology/Head and Neck Surgery, University of North Carolina, Chapel Hill, NC, USA, November 7, 2018. Seminar title: Improving the diagnosis and treatment of upper airway diseases through biomedical engineering.

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4. Workshop - Mathematical and Computational Challenges in Cilia- and Flagella-Induced Fluid Dynamics, Ohio State University, Columbus, OH, USA, October 16, 2012. Seminar title: Fluid homeostasis and its influence on cilia motility.

5. Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, June 18, 2010. Seminar title: Electrophysiology of the respiratory epithelium: regulation of mucus hydration in cystic fibrosis patients.

6. Cystic Fibrosis Focus Group, University of Illinois at Urbana-Champaign, Urbana, IL, USA, June 18, 2009. Seminar title: Computational model of extracellular nucleotide regulation in airway epithelia.

7. Rhinology 2008, São Paulo, SP, Brazil, May 23, 2008. Seminar title: Improving nasal surgery through bioengineering.

8. 2007 ANSYS U.S. Regional Conference Series: California, San Diego, CA, USA, April 4, 2007. Seminar title: Applying CFD to understand nasal physiology: atrophic rhinitis, a seminal study.

9. Department of Otolaryngology/Head and Neck Surgery, University of North Carolina, Chapel Hill, NC, USA, September 7, 2006. Seminar title: Atrophic rhinitis: is there a relation between airflow and pathophysiology?

OTHER TRAINING Clinical Research Scholars Program 09/10/2013 - 06/23/2015 – The goal of this program is to enable each Clinical Research Scholar to successfully compete for research funding. Each meeting (2 per month) starts with an hour-long seminar on topics related to clinical research (e.g., grant writing), research tools available at our institution (e.g., biostatistics support, clinical databases), and career-development (e.g., time management). Each seminar is followed by an hour-long small group session, in which scholars review each other’s grants and manuscripts in a style similar to NIH study sections. Concept to Clinic: Commercializing Innovation (C3i) Program - Phase I 08/2017 - 12/2017 – The C3i Program provides training for early stage biomedical project teams on how to commercialize their innovations. The program is organized by the National Institute of Biomedical Imagining and Bioengineering (NIBIB) and BIOCOMX, and it is based on the Coulter Commercialization Process. The program is designed to provide medical device innovators with the specialized business frameworks and essential tools for successful translation of biomedical technologies from the lab (concept) to the market (clinic). The curriculum and customized mentoring provided by the C3i Program are intended to guide investigators as they assess the commercial viability and potential business opportunity for their innovation. Phase I consists of a 2-day conference (boot camp), a series of interviews with stakeholders (physicians, patients, industry collaborators, hospital staff), biweekly mentoring sessions with business advisors, and a final presentation on our market analysis. Together with John Rhee M.D., I completed this training to assess the commercial viability of launching a company to offer virtual surgery planning for patients with nasal airway obstruction.

Documents

Guilherme Garcia PhD · 2020. 7. 22. · 1 Guilherme Garcia PhD Assistant Professor of Biomedical Engineering Marquette University & The Medical College of Wisconsin 8701 Watertown