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Genetics
Reference: Biology Textbook,
Chapter 11: Introduction to Genetics
Gregor Mendel
In 1865, Gregor Mendel published studies of inheritance in pea plants.
During sexual reproduction, male and female gametes (reproductive cells; n) join to form a zygote (2n) in the process known as fertilization.
Heredity is…
1. Controlled by “factors.” (known as genes on chromosomes)
2. Passed from generation to generation.
3.Predicted Outcomes through Probability using Punnett Squares.
1902 – Chromosome Theory of Heredity
Genes (Mendels “factors”) are located on chromosomes.
The different forms (variations) of a gene are called Alleles.
This is the basis for the modern science of Genetics.
Genetic Principles Dominant and Recessive
Dominant = seen when present on the chromosome Recessive = only seen when dominant allele is not present on
the chromosome
Law of Segregation and Independent Assortment Randomness Placement of chromosomes within the process of meiosis
Genotype and Phenotype Genotype – using letters to represent the trait’s alleles
Ex: Flower Color - FF, Ff, ff Phenotype – using descriptive words (adjectives) to describe
the trait’s alleles. Ex: Flower Color – Purple or white
Homozygous and Heterozygous Homozygous = same allele variations (TT, tt) Heterozygous = difference allele variations (Tt)
Genes VS Alleles
Gene
Allele
Genes VS Alleles
Gene Plant Height Flower Color
AlleleTall Plant Purple Flowers
Short Plant White Flowers
R.C. Punnett
In 1905, R.C. Punnett introduced the Punnett square.
Punnett squares can be used to predict and compare the genetic variations that will result from a cross (pg. 268).
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y
y
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y
y
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy
y
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy
y
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy
y Yy
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy
y Yy
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy Yy
y Yy
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy Yy
y Yy
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
Parents (P)
Y Y
y Yy Yy
y Yy Yy
Using Punnett Squares
Yellow pea seed (Y) is DOMINANT to green (y).
Genotype: YY x yy
Phenotype: Yellowx green
All (100%) offspring in F1 Generation are Yellow hybrids.
Parents (P)
Y Y
y Yy Yy
y Yy Yy
Monohybrid Cross
Yy x Yy
Yellow x Yellow
F1 Generatio
nY y
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y
y
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y
y
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY
y
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY
y
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY
y Yy
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY
y Yy
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY Yy
y Yy
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY Yy
y Yy
Monohybrid Cross
Genotype: Yy x Yy
Phenotype: Yellow x Yellow
F1 Generatio
nY y
Y YY Yy
y Yy yy
Monohybrid CrossGenotype: Yy x Yy
Phenotype: Yellow x Yellow
Phenotypic Ratio:
75% (3/4) offspring are Yellow; Ratio is 3:4 (Yellow : total)
25% (1/4) offspring are green; Ratio is 1:4 (green : total)
F1 Generatio
nY y
Y YY Yy
y Yy yyGenotype Ratio:
25% (1/4) offspring are YY, Ratio is 1:4 (homozygous dominant : total)
50% (2/4) offspring are Yy, Ratio is 1:2 (heterozygous : total)
25% (1/4) offspring are yy, Ratio is 1:4 (homozygous recessive : total)
Dihybrid Cross
Round pea seed (R) is dominant to wrinkled pea seed (r).
FOIL: YyRr YR, Yr, yR, yr
(These are the possible genotypic combinations)
Dihybrid CrossRound pea seed (R) is dominant to
wrinkled pea seed (r). Possible
Combinations
YR Yr yR yr
YR
Yr
yR
yr
Dihybrid CrossRound pea seed (R) is dominant to
wrinkled pea seed (r). Possible
Combinations
YR Yr yR yr
YR YYRR YYRr YyRR YyRr
Yr YYRr YYrr YyRr Yyrr
yR YyRR YyRr yyRR yyRr
yr YyRr Yyrr yyRr yyrr
What is the probability that the plant will produce:
Yellow, Round Peas:
Yellow, Wrinkled Peas:
Green, Round Peas:
Green, Wrinkled Peas:
Possible
CombosYR Yr yR yr
YRYYRR
Yellow, Round
YYRrYellow, Round
YyRRYellow, Round
YyRrYellow, Round
YrYYRr
Yellow, Round
YyrrYellow,
wrinkled
YyRrYellow, Round
YyrrYellow,
wrinkled
yRYyRR
Yellow, Round
YyRrYellow, Round
yyRRgreen, Round
yyRrgreen, Round
yrYyRr
Yellow, Round
YyrrYellow,
wrinkled
yyRrgreen, Round
Yyrrgreen,
wrinkled
What is the probability that the plant will produce:
Yellow, Round Peas: 9/16
Yellow, Wrinkled Peas: 3/16
Green, Round Peas: 3/16
Green, Wrinkled Peas: 1/16
Possible
CombosYR Yr yR yr
YRYYRR
Yellow, Round
YYRrYellow, Round
YyRRYellow, Round
YyRrYellow, Round
YrYYRr
Yellow, Round
YyrrYellow,
wrinkled
YyRrYellow, Round
YyrrYellow,
wrinkled
yRYyRR
Yellow, Round
YyRrYellow, Round
yyRRgreen, Round
yyRrgreen, Round
yrYyRr
Yellow, Round
YyrrYellow,
wrinkled
yyRrgreen, Round
Yyrrgreen,
wrinkled
To find the probability that two different events will happen at the same time, multiply the
probabilities of each event happening
separately.
To find the probability that two different events will happen at the same time, multiply the
probabilities of each event happening separately.
Probability of offspring having YELLOW pea seeds:
¾
Probability of offspring having ROUND pea seeds:
¾
Probability of offspring having BOTH YELLOW AND ROUND PEAS:
¾ X ¾ = 9/16
Trihybrid Cross
Tall Stem (T) is dominant to short stem (t).
The probability of producing tall stems in a monohybrid cross is:
What is the probability that the offspring in a trihybrid cross will be Yellow, Round, and Tall?
Trihybrid Cross
Tall Stem (T) is dominant to short stem (t).
The probability of producing tall stems in a monohybrid cross is:
¾ What is the probability that the offspring in
a trihybrid cross will be Yellow, Round, and Tall?
¾ X ¾ X ¾ = 27/64