Granulomatous diseases

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Granulomatous diseases. Dr Shaesta Naseem 13-10-12. Gross and histopathology. 1- Tuberculosis of the lung. Ghon’s Complex. Organ: lung Dx : Caseous necrosis (tuberculosis). Tuberculous Granulomas. Caseation Necrosis. Epitheloid cells in Granuloma. - PowerPoint PPT Presentation

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Granulomatous diseases

Granulomatous diseasesDr Shaesta Naseem13-10-12Gross and histopathology1- Tuberculosis of the lung

Ghons Complex



Organ: lung Dx : Caseous necrosis (tuberculosis)7

Tuberculous Granulomas

Caseation Necrosis

Epitheloid cells in Granuloma

11Necrotizing (i.e., caseating) granulomas filled with acid fast bacilli. This is CLASSIC for TB.

MORE ACID-FAST BACILLI, AFB 12The acid fast stain for acid fast bacteria is also called the Ziel-Neilseon stain, or simply AFB stainMiliary tuberculosis of the lung : Section of the lung shows : The alveolar septae contain many tubercles which consist of epithelioid cells , few langhans giant cells and peripheral rim of lymphocytes with or without caseation2- Tuberculous lymphadenitis

Tuberculous lymphadenitis :Section of a lymph node with connective tissue capsule and lymphoid tissue shows: Many round and oval tubercles/ granulomas with or without central caseation that appears structureless, homogenous and pink in colour.

The granulomas consists of epithelioid cells, few langhans giant cells (large cell with multiple peripheral nuclei) and peripheral rim of lymphocytes. 183- Bilharziasis of the colon COLONIC BILHARZIASIS



22Bilharziasis of the rectum\urinary bladder:Section of fragments of rectal\urinary bladder mucosa shows:Many Bilharzial ova with yellow brown shells in mucosa and submucosa surrounded by fibrosis and chronic inflammatory cells consisting of lymphocytes, plasma cells and many eosinophils.

Few granulomas are seen around the ova.235- Cutaneous leishmaniasis

Histological view shows marked cellular infiltration and parasites (Leishman bodies) within macrophages Picture shows a macrophage containing Leishmania amastigotes with characteristic features (round nucleus, rod-shaped kinetoplast; arrows) .