Glossary Bmp 8

7/29/2019 Glossary Bmp 8

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GLOSSARY

The Bone morphogenetic proteins (BMPs) are members of the TGF-beta

superfamily of cytokines that are involved in development, differentiation, and

disease. The transforming growth factor-beta (TGF-beta) super-family consists of

a large number of growth and differentiation factors, such as TGF-betas, activins,

inhibins, growth and differentiation factors (GDFs), and bone morphogenetic

proteins (BMPs).

These TGF beta ligands act through specific serine/threonine type I and

Type II receptor kinases. These type I and II receptor kinases subsequently

activate Smad proteins, which then propagate the signals into the nucleus to

regulate target gene expression. Several BMP isotypes have been identified

(BMP1 through BMP16) have been recovered through molecular cloning.

Recombinant protein products from several of these clones (BMP2-BMP16) are

members of the TGF-beta super-family of regulatory ligands. There exist high

degree of amino acid sequence homology between BMP5, BMP6, and BMP7, that

constitute a subfamily within the BMPs. The signaling systems of BMP are highly

conserved from flies to mammals and have been shown to be important in the

development of multiple organs.


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There are 2 variants fond in the BMP8 family (BMP8A and BMP8B).

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded

by theBMP8A gene. BMP8A is a polypeptide member of theTGFsuperfamily

of proteins. It, like otherbone morphogenetic proteins (BMPs), is involved in the

development of bone and cartilage. BMP8A may be involved

in epithelial osteogenesis. It also plays a role in bone homeostasis. It is adisulfide-

linked homodimer.

Gambar 1. Anti-BMP-8A antibody

Gambar 2. Anti-BMP-8A antibody
http://en.wikipedia.org/wiki/Proteinhttp://en.wikipedia.org/wiki/Genehttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Bone_morphogenetic_proteinshttp://en.wikipedia.org/wiki/Epithelialhttp://en.wikipedia.org/wiki/Osteogenesishttp://en.wikipedia.org/wiki/Homeostasishttp://en.wikipedia.org/wiki/Disulfidehttp://en.wikipedia.org/wiki/Homodimerhttp://www.antibodies-online.com/media/61/images/anti-BMP-8A+antibody_original_BS3092-001.jpghttp://www.antibodies-online.com/media/61/images/anti-BMP-8A+antibody_original_BS3092-001.jpghttp://www.antibodies-online.com/media/61/images/anti-BMP-8A+antibody_original_BS3092-001.jpghttp://www.antibodies-online.com/media/61/images/anti-BMP-8A+antibody_original_BS3092-001.jpghttp://en.wikipedia.org/wiki/Homodimerhttp://en.wikipedia.org/wiki/Disulfidehttp://en.wikipedia.org/wiki/Homeostasishttp://en.wikipedia.org/wiki/Osteogenesishttp://en.wikipedia.org/wiki/Epithelialhttp://en.wikipedia.org/wiki/Bone_morphogenetic_proteinshttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Genehttp://en.wikipedia.org/wiki/Protein


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Bone morphogenetic protein 8B is a protein that in humans is encoded by

theBMP8B gene. The protein encoded by this gene is a member of the TGF-

superfamily. It has close sequence homology to BMP7 and BMP5 and is

believed to play a role in bone and cartilage development. It has been shown to be

expressed in the hippocampus ofmurine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted

signaling molecules that can induce ectopic bone growth. Many BMPs are part of

the transforming growth factor-beta (TGFB) superfamily. BMPs were originally

identified by an ability of demineralized bone extract to induce endochondral

osteogenesis in vivo in an extraskeletal site. Based on its expression early in

embryogenesis, the BMP encoded by this gene has a proposed role in early

development. In addition, the fact that this BMP is closely related to BMP5 and

BMP7 has led to speculation of possible bone inductive activity.

Gambar 3. BMP8B Antibody

BMP8 is also known as osteonegenic protein 2 (OP 2). Closely related

BMPs may use the same or different receptor complexes for signaling in a time-

and space-dependent manner during development and differentiation. The BMP8

signaling requires involvement of mother-against-dpp (MAD) related protein 1

(MADr1) signaling pathway as a down stream component during meiotic male

germ cell differentiation. The Bmp8 gene is expressed in developing skeletal
http://en.wikipedia.org/wiki/Proteinhttp://en.wikipedia.org/wiki/Genehttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Sequence_homologyhttp://en.wikipedia.org/wiki/BMP7http://en.wikipedia.org/wiki/BMP5http://en.wikipedia.org/wiki/Hippocampushttp://en.wikipedia.org/wiki/Murinehttp://en.wikipedia.org/wiki/Embryoshttp://en.wikipedia.org/wiki/Embryoshttp://en.wikipedia.org/wiki/Murinehttp://en.wikipedia.org/wiki/Hippocampushttp://en.wikipedia.org/wiki/BMP5http://en.wikipedia.org/wiki/BMP7http://en.wikipedia.org/wiki/Sequence_homologyhttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Transforming_growth_factor_betahttp://en.wikipedia.org/wiki/Genehttp://en.wikipedia.org/wiki/Protein


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tissue and maps near the Achondroplasia locus on mouse chromosome 4. BMP8

Induces cartilage and bone formation. May be the osteoinductive factor

responsible for the phenomenon of epithelial osteogenesis. It also plays a role in

calcium regulation and bone homeostasis.


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List of References

1. Chen D, Zhao M, Mundy GR.Bone morphogenetic proteins. School ofMedicine and Dentistry, Department of Orthopaedics, University ofRochester, Rochester, NY 14642, USA. 2004. Dec;22(4):233-41.

2. John M. Wozney, PhD. Overview of Bone Morphogenetic Proteins. 2002.Volume 27, Number 16S, pp S2S8. Lippincott Williams & Wilkins, Inc.

3. http://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdf

4.

http://www.antibodies-online.com/antibody/460782/anti-BMP-8A/

5. http://www.lsbio.com/Antibodies/BMP8B-Antibody-LS-B790/33538
http://www.ncbi.nlm.nih.gov/pubmed?term=Chen%20D%5BAuthor%5D&cauthor=true&cauthor_uid=15621726http://www.ncbi.nlm.nih.gov/pubmed?term=Zhao%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15621726http://www.ncbi.nlm.nih.gov/pubmed?term=Mundy%20GR%5BAuthor%5D&cauthor=true&cauthor_uid=15621726http://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://www.lsbio.com/Antibodies/BMP8B-Antibody-LS-B790/33538http://www.lsbio.com/Antibodies/BMP8B-Antibody-LS-B790/33538http://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://cyber.law.harvard.edu/cyberlaw2005/sites/cyberlaw2005/images/Bone_Morphogenic_Protein_review.pdfhttp://www.ncbi.nlm.nih.gov/pubmed?term=Mundy%20GR%5BAuthor%5D&cauthor=true&cauthor_uid=15621726http://www.ncbi.nlm.nih.gov/pubmed?term=Zhao%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15621726http://www.ncbi.nlm.nih.gov/pubmed?term=Chen%20D%5BAuthor%5D&cauthor=true&cauthor_uid=15621726

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Glossary Bmp 8