IMANI HOLISTIC MEDICAL CENTRE (SOFIA, BULGARIA) WAS PROUD TO BE ANNOUNCED AS A GLOBAL MED ACADEMY CENTRE OF EXCELLENCE AND

REGENERATIVE MEDICINE TRAINING CENTRE

The American Cosmetic Cellular Medicine Association aims to find the best materials and procedures in Cellular Medicine in order to create a healthy body and educate physicians and patients about those observations.

Imani Holistic Medical Centre has the licensed rights to do The Vampire® Beauty Treatments registered and trademarked by Dr. Charles Runels. The biologically natural way of regenerating the cells through an injection of platelet-rich-plasma into the treated area.

• VAMPIRE FACELIFT®

Rejuvenating the skin of the face, neck and décolleté as correcting the shape, using blood derived growth factors: Platelet-Rich Plasma (PRP) injections and hyaluronic acid filler (Juvederm/Restylane).

Link to the procedure: https://www.youtube.com/watch?time_continue=1&v=1AItcxMthwA

• VAMPIRE FACIAL®

Microneedling facial procedure for rejuvenating the skin of the face using blood-derived growth factors: Platelet-Rich Plasma (PRP) injections.

• VAMPIRE BREAST LIFT® Renewing the skin of the breast and correcting shape, using blood-derived growth factors: Platelet-Rich Plasma (PRP) injections and a hyaluronic acid filler(Juvederm/Restylane).

Procedures: Vampire Facial® & Vampire Breast Lift® 🌡🌡How it works: Facial rejuvenation procedure of regenerative healing process using blood-derived growth factors, taken from the patient’s blood. 🎯🎯Results: • Stimulates collagen production • Removes face and breast wrinkles • Lifting and shaping the breast • Skin becomes tighter • Youthful appearance • Restoration of facial and breast shape • Growing out new and younger tissue • Improvement in skin texture and tone • Makes your skin soft • Removes scar marks and spots • Removes sagging skin • Fights with the factors of ageing • Improvement in the blood flow 💯💯Safety: • Non-surgical intervention • Using the patient’s own platelet rich plasma • No medications • No side effects 🔜🔜Recovery: Immediate to all daily activities �Pain level: Minimal 💉💉Method: The treatment uses 60ml of your blood. The sample is then placed in the latest technology (The Magellan® Autologous Concentration System), which optimally concentrates the platelets from blood plasma and is then injected into specific areas of the face. 💭💭Anaesthesia: Local anaesthetic cream ⏰Duration: 30 minutes 🚫🚫Contraindications: Blood disease 🧐🧐Specialist in Regenerative Medicine Dr.Dzihan Abazovic

• ORGASM SHOT® The biological approach of regenerating tissues using the patient’s own platelet-derived growth factors. When injected into the vagina, they stimulate cells to increase blood flow and restore tissues, improving the natural moisture and increasing the vaginal orgasm.

• PRIAPUS SHOT® Thee biological approach of regenerating tissues using the patient’s own platelet-derived growth factors. The platelets, taken from the blood release growth factors that are injected into the penis using a small needle.

! Look at the interview below !

https://www.facebook.com/watch/?v=465364873881919

• Vampire Hair Growth

Using PRP therapy as a treatment for hair loss will stimulate the hair follicles as well as the scalp and can promote hair growth that should result in noticeably fuller, thicker hair.

Starting February 2019, we have a new addition to the GRG as financial consultant to assist in wealth management, mergers

& acquisitions

Frederic Carbonnier is an international finance executive based in Geneva (Switzerland). Frederic has been a very successful advisor to families and entrepreneurs as a senior executive with some of the finest international banks. From 2010 to 2017, he held senior responsibilities for US key clients as CEO of UBP Investment Advisors (the entity of the UBP group focusing on US clients) and as senior banker with Pictet and Lombard Odier. From 2006 to 2010, Frederic was a Director with the international multi-family office Stonehage Flemming, advising ultra-high net worth families with their investment strategy, international tax and governance. Previously, Frederic was Finance Director of a New-York-based company in digital distribution of music (1997-2000). Frederic started his career as a corporate finance specialist for about 10 years with UBS in Geneva, Zurich and in New York.

Frederic graduated with a Master of International Relations from the Graduate Institute of Geneva (Switzerland). He passed the US FINRA series 7 & 66 exams. He is fluent in 5 languages and has 3 children. Frederic plays piano and is an avid skier and tennis player.

GRG SALES FORECAST 2019:

SALES FORECAST - MILIONS EURO 2019 2020 2021 2022 MAGELLAN 1.14 1.59 2.73 3.74 PRP 2.1 3.36 5.04 7.2 LIGHTNING & INQU 1.19 2.14 4.76 5.8 TOTAL: 4.43 7.09 12.53 16.74

Q1 2019 FY 2019 FY 2020 FY 2021 FY 2022 REVENUES 558,837 4,427,500 7,094,500 12,530,000 16,740,000 EXPENSES 687,118 4,227,420.00 6,432,356 10,874,240 14,325,920

COGS 451,540.30 3,577,420 5,732,356 10,124,240 13,525,920 SG&A 235,578 650,000 700,000 750,000 800,000

EBITDA -128,281.30 200,080.00 662,144 1,655,760 2,414,080

Depreciation 1000 3,000 4,000 5,000 7500

EBIT -

129,281.30 197,080 658,144 1,650,760 2,406,580 Interest -1105 -5,000 -10,000 -10,000 -10,000

EBT -

130,386.30 192,080 648,144 1,640,760 2,396,580 Reported Tax 0 0 30,468 295,617.42 437,895

Net Profit -

130,386.30 192,080 617,676 1,345,142.58 1,958,685 Cumulated Net Profit

-402,362.30 -79,896 537,780 1,882,922.58 3,841,607

IRAN TOTAL FORECAST 2019: $1,185,000

Magellan® Autologous Platelet Separator 30 x $7,000

PRP Kits 7,500 x $130

Target indications:

Hair fall-PRP

Skin aging-PRP

Osteo Arthritis-Autologous MSC

Target population:

Total population: 81.6 M

Target pollution for skin aging and hair fall: 75,000 per year

Target pollution for OA: 49,000 per year

Currently, 4 active cell therapy manufacturing companies offering similar services for these indications using autologous cell culture-based method (hMSC and human dermal fibroblast) in Tehran and about 600 MOH registered beauty clinics are active that are focusing on hair and skin beauty in big cities of Iran including Tehran, Shiraz, Isfahan, Tabriz, Rasht, Mazandaran province, and Mashhad. Thus, we can consider these clinics that are offering advanced point of care services and potential customer for Magellan products. So, we believe that we can sell at least 30 devices after first year of registration ordering 7500 kits per year for OA, skin disorders and hair applications with 10% increase per year.

ITALY TOTAL FORECAST 2019: $ 385,000

Magellan® Autologous Platelet Separator 20 x $7,000

PRP Kits 1,000 x $130

BMAC Kits 200 x $575

UAE, Oman, Qatar, Bahrain, Kuwait TOTAL FORECAST 2019: $ 900,000

First order - $100,000

With 14 Years of success and expertise in the field of Medical Aesthetic Devices, Products, Dermal Fillers, and Cosmeceuticals Industry.

ARAMED | Arabian Medical Enterprises LLC was founded by Eng. Khaled Younes in 2003, establishing the first office in the UAE. In 2005, we successfully crossed borders for the first time, expanding our venture to the GCC Market. Today we are proudly covering the entire Middle East and North Africa Region, and celebrating 14 years of success and expertise, with a remarkable presence in the industry, and an outstanding position amongst competitors.

ARAMED sets the highest standards in the field of Medical Aesthetic Devices, Products, Dermal Fillers, and Cosmeceuticals. Driven by a unique team that consists of Doctors, Pharmacists, Engineers, Technicians, Specialists, and Support Staff, working together, utilizing a multitude of innovative approaches, after sales service, and marketing support to provide complete customer satisfaction.

SAUDI ARABIA TOTAL FORECAST 2019: $ 1,000,000

First order - $175,000

AME-KSA is Specialized in providing Total Solutions for the unique practice of Specialized Dermatologists,Plastic and Cosmetic Surgeons.

Global Regenerative Group Attended Advanced Workshop In Bologna (Feb 22nd- Feb 24th ) With Huge Success

In recent years Regenerative Medicine has endorsed and consolidated, the therapeutic importance of PRP in the repair and regeneration of damaged tissues in orthopedics, in maxillofacial surgery, in dentistry and odontostomatology, in ophthalmology, in the treatment of chronic skin ulcers, in plastic surgery and aesthetic medicine. The use of PRP (platelet-rich plasma) represents a new frontier but the regulations and protocols are very precise. Essential in clinical practice is the use of the correct fraction containing the platelet concentrate and, previously, the attention to the process that leads to the adequate concentration of the same platelets. INVITATION TO THE WORKSHOP PRP: Clinic, legislation, applications and responsibilities Saturday 23 February - 12:00 Sala Celeste 22nd SIES CONGRESS

Global Regenerative Group MEDICAL TRAININGS CONDUCTED IN FEBRUARY 2019:

February 4-8, Israel Trimaco visit Military doctors Aesthetic field launch February 8-10, Athens, Greece Rea Hospital presentation Regenerative Gynecology Lichen Sclerosus study (Dr. Mortakis and Dr. Chrysostomou) February 12-18, Dubai, UAE Academy meeting with Hair loss KOL/Trainer Dr. Shadi Zari http://drshadizari.com/?lang=en Novomed training Aramed sales team training Global Regenerative Care discussion February 18-22 Sofia, Bulgaria IMANI - Aesthetic training Global Regenerative Academy board meeting to finalize the Global Regenerative Congress 2019 in Sofia (September 6-8,2019) February 26-28, Kuwait Aramed Magellan TruPRP introduction

What’s Trending Now

Platelet-Rich Plasma Is Profitable, But How Well Does It Work?

By Chuck Dinerstein — February 12, 2019

Courtesy of Winrad1971

Ah, the mighty platelet. Once a neglected blood component, today it is the basis of an entirely new medical “specialty,” regenerative medicine, although market might be a better word choice.

The use of blood products in roles other than transfusion began almost a half-century ago when fibrinogen was used as a type of glue, to put tissue together. Platelets, neither a cell, like the red or white blood cell, nor a metabolite, like fibrinogen, is a cell fragment (no nucleus). It is deeply involved in tissue repair, helping to form clots to fix a leaky blood vessel and containing a number of growth factors that signal and stimulate cell proliferation and remodeling – enhancing healing. When an agent that may promote healing meets tissue that is, often, difficult to heal, well, this is either a match made in scientific or marketing heaven.

A $45 million market in 2009, Platelet Rich Plasma or PRP sales quadrupled by 2016 and growth is estimated to continue at about 12 to 13% annually. The indications for the use of platelets initially for orthopedic problems was extended to the pain for those same orthopedic issues, to wound healing in general and even hair restoration. Platelets can be used by themselves or in conjunction with other medications and procedures. For physicians looking for a procedure, PRP is about as good as it gets.

From a medical perspective, it is a natural product, coming from the patient themselves, so little worry about allergic reactions or harmful side effects. As to the pesky issue of whether it is a cure-all or snake-oil, that depends on what you read and what was studied. One meta-analysis of 109 published studies found that more than half were literature reviews and meta-analysis, in the words of the author, “there is more talk than real attempts to understand how this treatment could be useful in the clinical practice.”

Does PRP work?

The first problem in finding value in PRP is that like the blind men and the elephant; everyone has a different definition of what PRP means. Creating that rich plasma begins by taking about 2 ounces of your blood and spinning it in a centrifuge that separates components by their weight. The red blood cells are at the bottom of the tube, plasma with very few platelets is on the top, and in between, there is a “buffy coat,” where the platelet rich plasma is to be found. PRP can mean just pure platelets, or it may include white blood cells and/or fibrin, the product of fibrinogen. So overall there can be four different forms of PRP based on how long and fast the blood spins in the centrifuge. But once made, in less than an hour in the doctor’s office, they are “activated” causing them to release their signals and growth factors and injected into the problematic body part.

As a result, studies are frequently comparing apples to oranges or some other metaphorical fruit. From a marketing view, the act of concentrating the platelets and knowing how and where to inject them results in charges ranging from $500 to upwards to $2,000 [1] with insurance covering little of the cost. So, we are talking cash, check or credit card. Medicare does not include these treatments, and to be honest, Medicare covers nearly everything that shows efficacy.

The second concern in finding PRP’s value is where this aid to healing is applied. Bones, cartilage, and tendons have poor blood supplies compared to other tissue. As a result, all the cellular goodies necessary for healing transported through the blood have difficulty getting to these tissues, and healing is slowed. The same is true for what vascular surgeons would describe as “non-healing” wounds of the legs, where again the blood supply is compromised as is the healing. Another purported indication for PRP is in the treatment of pain associated with those orthopedic injuries, which do hurt and do not always respond to non-steroidal or steroidal anti-inflammatory drugs (Opioids, of course, are less frequently indicated and in today’s cultural climate banished)

Let the patient beware

An international orthopedic review suggests “PRP may provide some benefit in patients who have knee osteoarthritis and lateral epicondylitis” - often referred to as “tennis elbow.” For all the other orthopedic indications results were inconsistent. They ended by recommending that the evidence-based clinician be “weary,” although I am pretty sure that they meant wary, in applying PRP to their practice. The American Association of Orthopedic Surgeons felt that the use in knee osteoarthritis was “inconclusive,” and there had been “some success” in treating lateral epicondylitis. Neither a real recommendation. The Cochrane group found “the available evidence is insufficient to support the use” of PRP for orthopedic soft tissue injury, and as for wound healing “PRP

may improve the healing of foot ulcers associated with diabetes, but this conclusion is based on low-quality evidence…”

Does PRP help? The bottom line is that we can point to the articles of our choice, but we do not know. Despite its theoretical biologic plausibility, it has yet to demonstrate its practical value in large populations.

[1] Not all of those charges return to the physician. Every company in the regenerative medicine business of PRP retrieval and application sells its own brand name “harvesting kit” at prices from $175 to over $1,000.

Sources: Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Cell DOI: 10.1016/j.tibtech.2008.11.009

PRP: more words than facts Knee Surgery Sports Traumatology Arthroscopy DOI:10.1007/s00167-012-2136-x

An evidence-based evaluation on the use of platelet-rich plasma in orthopedics – a review of the literature SICOT-J DOI: 10.1051/sicotj/2017036

Platelet-rich therapies for musculoskeletal soft tissue injuries Cochrane Library

Autologous platelet-rich plasma for treating chronic wounds Cochrane Library