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CALIFORNIA TUMOR TISSUE REGISTRY

"GENITOURINARY PATHOLOGY"

Study Cases, Subscription A

February 2008

California Tumor Tissue Registry c/o: Department of Pathology nnd Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@ljnkljne.coltl Web page: www,cttr.org

Web site & Case of the Month : www.cttr.org

Target·audjence: Practicing pathologists and pathology residents.

Goal: To acquaint the participant with the histologic features of a variety of benign and

malignant neoplasms and rumor-like conditions.

Ob!ectives: The participant will be able to recognize morphologic features of a variety of ben:ign

and malignant neoplasms and rumor-like conditions and relate those processes to pertinent references in the medica! lilerature.

Ed ucational methods and media: Review of representative glass slides with associated his10ries. Feedback on consensus diagnoses rrom pm1icipating pathologists. Listing of selected references from the medical literarure.

Principal faculty: Weldon K. Bullock, MD Donald R. Chase, MD

CMECredit: Lorna Linda University School of Medicine designates th is continuing medical

education activity for a maximum of2 hours of Category I of the Physician 's Recognition Award of the American Medical Association.

CME credit is offered for the subscription year only.

Ac-creditation: Loma Linda Un iversity School.ofMedicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) 10 sponsor continuing medical education for physicians.

Contributor: Lester Thompson, M.D. Case No. 1 - February 2008 A Woodland Hills, CA

Tissue from: Prostate Accession 1#30597

Clinical Abstract: Complaining of urinary retention, this 59 year old man presented to his urologist. His PSA

levels were mi ldly elevated and CT scan showed an enlarged prostate. Digital exam showed an enlarged but smooth prostate. Biospies were initially benign. A suprapubic prostatectomy was performed at which time a presumed adenoma was enucleated from the surrounding prostatic shell.

Gross Pathology: The specimen weighed 89 grams and was 6 x 5 x 3/S em.

Contributo r: Lester Thompson, M.D. Case No. 2 - Febr uary 2008 A Woodland Hills, CA

Tissue from: Kidney Accession #30678

Clinical Abstract: A 54 year old woman with a long history of polycythemia presented with left nank pain and

hemalllria. Radiographic studies showed a 2 .5 em mass in the kidney parenchyma.

Gross Pathology: The resected specimen included a well-circumscribed pale gray, slightly sof1 mass with focal

cyst formation and areas of calcification.

Contributor: LLUMC Pathology Group (cz) Lorna Linda, CA

Tissue from: Right kidney

Clinical Abstract: A 3 year old boy was found to have a larger rena l mass.

Gross Pathology:

Case No.3 - February 2008 A

Accession #30704

The 770 gram, 16 x 12 x 6 em radical nephrectomy specimen was largely replaced by tumor, with flucuant cystic necrotic areas in the upper pole. In the lower pole was a mixture of renal parenchyma and tumor nodules up to 4 em in diameter.

Contributor: LLUMC Pathology Group (cz) Lorna Linda, CA

Tissue from: Kidney

Clinical Abstract:

Case No.4 - February 2008 A

Accesssioo #30499

A 5 year old boy was found to have both renal and brain masses. A radical nephrectomy was performed.

Gross Pathology: The 700 gram, 15 x 13 x 7 em nephrectomy specimen had a 12 x 9 x 7 em white-tan, soft,

friable tumor largely replacing the kidney.

Contributor : Catherine OdeJJ, M.D. Case No. 5 - February 2008 A Rivers ide, CA

Tissue from: Right kidney Accession #30676

Clinical Abstract: During work up for hypertension, this 53 year old man was found by ultrasound to have a right

renal mass. An MRI showed a solid mass with a cystic center.

Gross Pathology: The 770 gram radical nephrectomy specimen had an 8 x 5 x 4 em well -circumscribed red­

brown mass with a central scarred area present in the upper pole of the kidney.

Contributor: LLUMC Pathology Group (gs) Lorna Linda, CA

Tissue from: Left kidney

Clinical Abstract:

Case No. 6 - February 2008 A

Accession #30703

This 60 year old woman was found to have a left renal mass and retroperitoneal lymphadenopathy.

Gross Pathology: The I ,480 gram, 18 x 15 x 9 em nephrectomy specimen showed a kidney largely replaced by a

white to yellow-tan tumor.

Contributor: Lester D.R. Thompson, M.D. Case No. 7 - February 2008 A Woodland Hills, CA

Tissue from: Kidney Accession #30681

Clinical Abstract: This 67 year old mao presented with left flank pain and hematuria. Work up showed renal

mass.

Gross Pnthologv: The tumor was 4/5 em in greatest diameter.

Contributor: LLUMC Pathology Group (kt) Lomu Linda, CA

Tissue from: Bladder

Clinical Abstract:

Case No. 8 - February 2008 A

Accession #30563

A 71 year old man was found to have a mass in the bladder base with extension into the adjacent prostate.

Gross Pnthology: The 470 gram, 21 x 12 x 7 em cystoprostatectorny specimen showed a 7 ern diameter white-tan,

focally hemorrhagic tumor arising from the base ofthe bladder and encompassing the urethra and extending into the underlying prostate and into the peri vesicular fat.

Contributor: LLUMC Pathology Group (kt) Lorna Linda, CA

Tissue from: Ureter

Clinical Abstract:

Case No. 9 - February 2008 A

Accession 1130721

During work up for an abdominal aneurysm, this 7S year old woman was found to have right hydronephrosis and a right ureteral obstruction.

Gross Pathology: The 600 gram 15 x 6 x 1 em composite resection of kidney and ureter showed a white-tan

friable mass completely filling the ureteral lumen.

Contributor : Lester Thompson, M.D. Case No. 10 - Febr uary 2008 A Woodland Hills, CA

Tissue from: Adrenal gland Accession 1130680

Clinical Abstr act: A 9 1 year old man presented with hematuria and abdominal pain . A renal pelvis mass was

identified radiographically.

Gr oss Pathology: The 4.5 em mass in the renal pelvis extended into renal parenchyma. The accompanying

adrenal also contained a tumor.

CALIFORNIA TUMOR TISSUE REGISTRY

ITOURJNARY PATHOLOGY

M$utes ....: Subscription A

Febmazy, 2008

SUGGESTED READING (General Topics from Recent Literature):

Risk of Pancreatic Adenocarcinoma in Patients with Hereditary Pancreatitis. A National Exhaustive Series. Rebours V, Boutron-Ruault MC, et al. Am J Gastroenterol2008; 103:111-119.

A Comparison of Aspiration Cytology and Core Needle Biopsy According to Tum.or Size of Suspicious Breast Lesions. Barra A de A, Gobbi H, et al. Diagn Cytopatho/2008; 36:26-31.

Small Cell Carcinoma of tbc Prostate. A Morphologic and Immunohistochemical Study of 95 Cases. Wang W and EpsteinJI. Am J Surg Pathol2008; 32:65-71.

Utility of WT ·1, p63, MOC31, Mesothelin, and Cytokeratin (K903 and CKS/6). lmmunostains in Differentiating Adenocarcinoma, Squamous Cell Carcinoma, ana Malignant Mcsotbclio.roa in Effusions. Pu RT, Pang Y, and Michael CW. Diagn Cytcpatho/2008; 36:20-25.

Growth Factor Receptors Expression in Anaplastic Thyroid Carcinoma. Potential Markers for Therapeutic Stratification. Elliott DD, Sherman SI, ct al. Hum Patho/2008; 39:15-20.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Loma Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@linkline,com Web site & Case of tbe Month: www.cttr.org

FILE DIAGNOSES

CTIR Subscription A February 2008

Case 1:

Case 2:

Case 3:

Case 4:

Cose S:

Case 6:

Case 7:

Case 8:

Case9:

Prostatic stromal tumor of uncertain malignant potential T -77100, M-72450

Metanephric adenoma, kidney T-71000, M-91100

Wilms tumor, kidney T-71000, M-89603

Clear cell sarcoma, kidney T-71000,M-90443

Oncocytoma, kidney T-71000, M-82900

Poorly differentiated renal cell carcinoma with granular cell features, kidney T-71000, M-83123

Papillary renal cell carcinoma T-71000, M-83123

Small cell carcinoma, bladder and prostate T-77100,M-80413

Urotbelial carcinoma in-situ, kidney and ureter T -73000, M-81203

Case 10:

2

High-grade urothelial (transitional) carcinoma, kidney T-71000, M-81203

Case No. 1, Accession No. 30597 February 2008

Alameda (Alameda Counlv Me<lical Cepte£) • Stromal tumor of UllCertain maligDaol potential A£cadia (ABC laboratories) · Benign stromal tumor with smooth muscle differentiation fontana (Kaiser Permancnte) - Pecoma Hayward/fremont - Leiomyoma, prostate L;t Jolla (Scripps Clinic) - Prostatic stromal sarcoma l.a.DC Beach (Long Beach veterans Hospital) - Solitary fibrous tumor (J) Moumain View (EI Camino HosllilJIO - Stromal nodule Oakland • Spindle cell nodule Orange (Orange County Patholosy) • Benign fibrohistioctyic lesion Oxnard (St. John's Regional Medical Center) - Solitary fibrous tumor (2); Proliferative stromal lesion (1) Sag Diego CNaya! Me<lical Ccme(l - Post -operative spindle cell nodule San Qjeoo CRCRMQ • Spindle cell lesion r/o stromal sarcoma, fibrous histiocytoma, solitary fibrous tumor San Francisco (YCSF Fel!ow:t) - Pseudosarcoma San Francisco (San Francisco Geqeml Hospital) - Sclerosing adenosis Santa Barbaro • Leiomyosarcoma Santa Bnrbarn (Cottage Hospital) • Prostatic stromal tumor of uncertain malignant potential Santa Rooa (,Santa Rosa Memorial Hospilgl) • Leiomyoma (3) Sonoma - rotlammatory pseudotumor (inJlamroatory myofibroblastic tumor) Alnbnmn (13aptist Medical Centet) - Hemaogiopericytoma Alabama. MI. Olive · Prostatic stromal tumor of unknown malignant potential Colorado (McKee Medical Cemet) - langcrhan's ceU histiocytosis f!ori!la IJallahas<ee Pathology A«n«;al<:~ • Stromal nodule Gcor11iA . Decatur - Stromal neoplasm of uncertain malignant potential Dlioois, Burr Ridge - Prostatic stromal uncertain ma!lgnant potential !!!ioois (Heartland Regional Medical Center) - Prostatic stromal neoplasm of uncertain malignant potential Indiana (MacNeal Hospital) - Spindle cell tumor, meningioma vs. po:;top spindle cell nodule vs. hemangiopedcytoma lndiaon (St. Joseph Hospital) - Post operative spindle cell nodule (1); lnOammatory pseudotumor (1) Kansas (J::ytocheck l,abomtocy) - Inflammatory pscudotumor (2) Louisiana (Orleans Parish O!rogcr's Office) - loflamroatory pscudotumor (2) Massachusetts @erksbjre Medical Center) · Leiomyoma, cellular type Messaohusetts £Tufts-New En11land Medical Center) - Inflammatory pseudotumor Messeohusctls CUMASS Memorial Medical Center) - Spindle cell lesion favoring leiomyoma Mjchjgan (pathology ,Service.• of We..~ Michigan) - STUMP Mjnnesota (fairview Rid11e..• Hosnital) • Hyperplastic stromal nodule vs. solitary fibrous tumor Nebraska @•i&hton Universi!y Medical Center) • Peroma New Mexico (Albu!J!lcrque) - Stromal sarcoma New Mexico (Yoiversily of New Mcxicq) • Soliiary fibrous tumor New York (I!CMQ - Inflammatory myofibroblastic tumor New York (Lon II Island Jewish Mcdjcal Center) - Post-operation spindle cell tumor New York (Stony Brook Uoivcrsjty Medical Center) • Stromal nodule of hyperplasia Ohio (McCullough-Hyde Memorial Hospjta!) • Spindle cell nodule vs. pseudotumor Pennsylvania (Corunaugh Memorjal Hospital) - Leiomyoma Ps;pMylyania (Prexel Medical Cco(cr) • Leiomyoma PenMylyania (l..ehigh Valley Hospital) - Solitary fibrous tumor PcnMylyania (Magee Women's HJW!ilal) - Prostatic stromal sarcoma Pennsylvania (St. E!i2abeth Health Ccntc(l - Solitary fibrous tumor of prostate Tcgn"'i'U (]ast Tennessee Stale University) - Leiomyoma Texas, Crystal Beach - Carcinoma squamous spindly Texas. Houston · Spindle cell tumor, follicular dendritic cell vs. io.flammatory fibroblastic tumor Texas, L,ubbock - Leiomyoma Texas ISco!l & White Memorial Hosojtal) - Benign stromal tumor, favor Pecoma Texas Cfhc Methodist Hwpital) - Leiomyoma Washington (Seattle VA Me<lica! Ceo1e(l - Prostatic srromaltumor, uncertain malignant potential Wcs1 Vjrgjqia jpreenhricr Valley Medical Cegte(l • Lciomyomatous hyperplasia

3

Australia (Royal Hnhan Hospital) • Solitary fibrous tumor Brazjl. Sao Paulo • Leiomyoma vs. leiomyosarcoma Qtnada (pasaua Hospital) · Stromal sa.reoma canada (.Uniyersilv Hospital Shcrbrooke) • Myolibroblastoma Hong Kong <Hong Kong Baptist Hospital) • Leiomyoma Ireland (Kerry General Hosp.j(al) • ? post-op spindle cell nodule, 7 solitary fibrous tumor Ireland (.Uniyernily College Ho:ipjtal) • Solitary fibrous tumor-prostate Japan (Asa!;hl General HO§o.itaD • Inflammatory myofibroblastic tumor Japan (Kyoto Universitv Hospital) • Spindle cell tumor (solitary fibrous tumor?) Saudi Arabia (King Abdulazjz Medical City Group) • Leiomyoma United Kinwdom (lohn Radcliffe Hospital) • Solitnry fibrous tumor Oman (Sul!anqt of Oman) • Solitary fibrous tumor

Ca.<e 1 . Diamosis: Prostatic stromal tumor or uncertain malignant potential

T-77100, M-72450

case 1 • References: Klausner AP, Unger P, Fine EM, ct al. Recurrent Prostatic Stromal Proliferation or Uncertain Malignant Potential. A

Therapeutic Cballenge. J Uro/2002; 168:1493-1494. Hera"i M and Epstein n. Spcei3lizcd Stromal Tumors of the Prostate. A Oinicopathologic Study of 50 Cases. Am J

Surg Patlw/2006; 30(6):694-704. Wee HM, Ho SH, Tan PH, et al. Recurrent Prosuuic Stromal Tumour of Uncertain Malignant Potential (STUMP)

Presenting with Urinary Retention 6 Yearn After Tmnsurethral Resection of Prostate (TURP). Ann A cad Med Singapore 2005; 34(7):441-442.

Kakuta Y, Kobayashi Y, Tanaka M, et a!. A Case of Prostatic Stromal Tumor of Uncertain Malignant Potential. Hinyokika Kiyo 2005; 51(U):843-846.

Bostwick DO, Hos.>;ain D, Qian J, et al. PhyUodes Tumor of the Prostate. Long-Term Followup Study of23 Cases. J Uro/2004: 172(3):894-899.

Case No. 2, Accession No. 30678

Name<la CA!ame4a County Medical Center) - Metanephric adenoma Arcadia (ABC !.4horatories) • Metanephric adenoma Fontana (Kaiser Permanent() • Metanephric adenoma Hayward/Fremont - Metanephric adenoma La Jolla (Scripps Clinic) • Metanephric adenoma Long Bc3ch (Long Bc3ch Veterans Hospital) • Mclanephric adenoma (7) Mountain View CE! Camino Hw;phaD · Metanephric adenoma Oaldand • Metanephric adenoma Orange (Orauae County Patholoay) • Metanephric ndenoma Oxnard (St John's Regional Medical Center) • Mctanephricadcoomu (3) San Diego (Na¥nl Medical Centcc) · Metanephric adenoma San Diego (RCRMQ · Metanephric adenoma (r/o renal cell carcinomn, capsule) San francim (.UCSF Fellows) · Metanephric adenoma San Francim (San Francisco Gencrnl Hospital) - Metanephric adenoma Santa Barham • Metanephric adenoma Santa 13arbara (Cottage Hospital) • Metanephric adenoma Santa Rosa (Santa Rosa Memorial Hospital) · Metanephric adenoma (3) Sonoma - Metancphric"adenofibroma Alabama @aptj•1 Mcslical Center,) • Metanephric adenoma A]abama. Mt. Olive - Metanephric adenoma Colorado (McKee Medical Ccn!er,) • Metanephric adenoma Florida (J)illnh•s.we Pathology AsSOciate'!) • Metanephric adenoma Georgia • Dcguyr • Metanephric adenoma

4

February 2008

Illinois. Byrr Ridge - Metanephric adenoma Illinois (Jieart!apd Bc~onal Medical Center) - Metanephric adenoma Indiana CMacNeal Hospital) - Metanephric adenoma • Indiana CSt. Jm;c;ph HoSpital) - Renal cortical adenoma (1); Metanephric adenoma (1) Kansas CCVJocheck I.abomtorv) - Metanephric adenoma (2) Louisiana (Orleans Parish Coroner's Offics;.) - Metanephric adenoma Massachusetts (Ilcrkshire Medical Center) - Metanephric adenoma Massachusetts O'uft.<;-New England Medical Center) - Metanephric adenoma Massachusetts (JJMASS Memorial Medical Center) - Metanephric adenoma .MWJjgnn (l'athology Services of West Michigan) - Metanephric adenoma Minnesota (fairview Ridges Ho$pjtal) - Metanephric adenoma Nebraska (Creighton University Medical Center) - Metanephric adenoma New Mexico (Aibuaueroue) - Metanephric adenoma New Mexico (J.Jniversitv of New Mexjcq) - Metanephric adenoma New York (J!CMQ - Metanephric adenoma New York (Long Island Jewjsh Medical Center) - Metanephric adenoma New York (Stony Brook Univernity Medica! Cenler) - Metanephric adenoma Ohio (McCullough-Hyde Memorial Hospital) - Metanephric adenoma Pennsylvania (Conmaugh Memorjql HosPital) - Metanephric adenoma £gjw.sylyania (Prexel Medical Center) - Metanephric adenoma Pennsylyania (Lehigh Valley Hospital) - Metanephric adenoma Pennsy!yania (Magee Women's Hospital) - Metanephric adenoma Pennsylyania CSI. Elizabeth Health Center) - Metanephric adenomtt TennAA<£4 (Jlast Tennessee State Uniymity) - Metanephric adenoma Texa.<. Casta! Beach - Renal conical adenoma Ten.<. HouSion - Metanephric adenoma Texas. Lubbock - Nephrogenic adenoma Tcxa.~ (Scott & White Memorial Hosllitilf) - Metanephric adenomtt Texas (Ibc Me)hodist Hospital) - Metanephric adenoma ~@ton (Seattle VA Medical Center) - Low gmde epithelial neoplasm (metanephric adenoma) West VirQjnia (Greenbrier Valley Mcdjea! Center) - Papillary renal cell carcinoma Australia <Royal Hobart Hospital) - Metanephric adenoma Bmzi!. Sao Paulo - Metanephric adenoma Canada (Pasqua Hospital) - Metanephric adenoma Canada Qlnjycrsity Hospital Sberbmoks;.) - Metanephric adenoma Hong Kong (Hong Kong Baptist HOSJlital) - Metanephric adenoma Ireland (Kerry General Hospital) - Metanephric adenoma Ireland (llnjversity College Hospi!al) - Metanephric adenoma Jilpan (Asasbi General Hospital) - Metanephric adenoma ,htpan (Kyoto University Ha•'Jli13!) - Metanephric adenoma Saydi Arqbja (King Abdulaziz Mcdjcal City Groull) - Metanepbrlc adenoma United Kingdom (Johp Radclitfc Hoslli!!!) - Metanephric adenoma Oman (.Sultana! of Oman) - Metanephric adenoma

Ca!!e 2 - l)lagnosis: Metanephric adenoma, kidney

T-71000, M-91100

Car,e 2 .. References: Lerul E, Roskams T, Joniau S, et al. Metanephric Adenoma During Pregnancy. Clinical Presentation, J-listology, and

Cytogenetics. H11m Patho/2006; 37(9):1227-1232. Rakhcja D, Lian F, Tomlinson GEl, ct al. Renal Metanephric Adenoma with Previously Unreported Cy~ogcnctic

Abnormalities. Case Report and Review of the Literatll[e. Pedlatr Dev Patltol2005; 8(2):218-223. Iqbal J, Gupta S, llreucr FU, et al. Renal Metanephric Adenoma witb Previously Unreported Cytogenetic

Abnormalities. Case Report a.nd Review of tbc Literatll[e. Pediatr Dev Potlrol2005; 8(2):218-223. Iqbal J, Gupta S, Breuer FU, et al. Metanephric Adenoma Mimicking Papillary Carcinoma Arising in a Mixed

Epithelial and Stromal Tumor orthc Kidney. Cancer Genet Cytogt:IU!t2006; 170(1):83-85.

C1'!'R, l'<bMJy 2008 "Minutes" (Sub5criptloa A)

Paner GP, Turk TM, Oarldl, ct al. Passive Seeding in Metanephric Adenoma. A Review of Pseudomeln.static Lesion in Peri.ncpbric Lymph Nodes. Arch Palhol Lab Med 2005; 129(10):1317· 1321.

Atgani P. Metanephric Neoplasm. The Hyperdiffcrcntiated, Benign End of the Wdrns Tumor Speclrum? CUn Lab Med 2005; 25(2):379·392. .

Case No. 3, Accession No. 30704

Alameda (Alameda County Medical Center) • Nephroblastoma 6rcadia (ABC Laboratories) • Clear cell sarcoma Fontana (Kaiser Permnncnte) • WiJm's tumor Hayward/Fremont • Wilm's tumor La Jolla (S<:ripos Oioic) · Wilm'stumor lAng Beach (l.oog Beach Veterans Hosoital\ • Wilm 's rumor (1) Mountain Yiew (pi Camino Hospital) • Wilm's tumor Qakland - Wilm 's tumor Qrangc (Qrange County Patbolouy) • Wilm's tumor Qxnard (St. John's Regional Medicnl Center) • Nephroblastoma (3) San Die!W (Naya! Medical Center.) • Nepbroblastoma San Die!W (RCRMC) • Nephroblastoma San Francisco CUCSF Fellows) · Wilm's tumor, blastema-predominact San Francisco (Sap Francisco Genera( Hospital) • Wilm's tumor Santa Barha[ij • Nephroblastoma Santa Barbara (Couage Hospjtal) - Ncphroblastoma Santa Rosa (Sapta Rosa Memorial Ho.•(li!al) · Wi!m 'stumor (3) Sonoma - Ncphroblastoma Alabama ogptist Medical Center) • Wilm's tumor Alabama, Mt Oliy9 • Ncphroblastoma (Wtlm's tumor) Colorado (McKQQ Medical Ccpter) • Nephroblastoma Florida (Iallahnssce Pathology Assocjates) • Wilm 's tumor Georgia, Dccatuc • Wilm's tumor, blastema predominant !l!jpois, Burr Rid it · Cystic nephroma Dlinois (Heartland Regional Medical Center) - Nephroblastoma Indiana (MacNeal Hospital) • Wilm 's tumor, blastema type Indiana (St. Joseph Hosoital) • Ncphrobl~ioma (1); Wilm's rumor (1) Kansas (Cytochcck Laboratory) • Wilm's tumor, blastema! (1); Nephroblastoma (1) Louisiana (Orleans Padsh Coroner's Qffice) • WUm's tumor Massachusetts @crksbj[e Medical Q;ntcr) • Ncphroblastoma (Wilm 's), anaplastic type Mao;.sachusetts Q'uft.•-New England Medical Cente() • Neuroblasroma vs. WUm's Massru;busetts (lJMASS Memorial Medical Centc() • Wilm's tumor Michigan (Patholo~ Services of West Michigan) • Wilm's diffuse blastema! Minnesota (Fairyiew Ridges Hospital) - Nepbroblastoma Nebraska (CreighJOn University Medical Center) • Wilm's tumor (ncphroblastoma) New Mexico (Aibyqucroue) - Nephrob!astoma New Mcxjco CUpjyersity of New Mexico) · Wilm's tumor New York CECMC) • Nephroblastoma N!)W York (Long Island Jewish Medical Center) - WiJm's tumor New York (Stony Brook Uniyersitv Mc<lica! Center) - Wilm's tumor Ohio (McCullough-Hyde Memorial Hosp,ital) - Ncphroblastoma Pcnnsylvani;• (Conmaugh Memorial Hospital) · Wilm's tumor Pe!ll!Sylvania CDrcxel Medical Cen(ct) • Wilm's tumor, favorable prognosis type Pe!ll!Sylvania CLcbjgh Valley Hospi(al) · Nephroblastoma Peonsvlvania (ll1aRAA Women's Hospital) - Wilin's tumor Pennsylvania (St. Elizabeth Health Ceptet) - Neuroblastoma tennessee (.East Tennessee State Upiyersity) - Wilm's tumor Texas. Crystal Beach • Nephroblastoma

February 2008

6 CITR, Fcbn..,y 2008 "Minmos" (Sobocripcioo A)

Texas. Hou.,ton - Wilm's tumor Texas, !.ubboclc - Wilm's tumor Texas (Scott & White Memorial Ro.wital) - Nephroblastoma. Texas (The Methodist Hospital) - Nephroblas10ma Wn.<hington (Seattle VA Medical Center) - High grade blastemal/little epithelial neoplasm (Wilm's) West Virginia (Greenbrier valley Medical Center) • NcphrobJastoma Australia (Royal Hobart Hospital) - Nephroblustomu Brazil. Sao Paulo - WUm's tumor, 99% blstemul components Canada (Pasaua Hospital) • Ncphroblastoma Omada (Yniversjty Hospital Shemrooke) - Wilm's tumor Hono Kong (Hopg Kon~ Baptist Ho.wital) - Nephroblastoma Ireland (!{erry Gepcral Hospital) - Wtlm's tumor Ireland (Ynivernitv Co !lese Hospital) - Wilm's tumor Japan (Asashi General Hpspjtal) • Nephroblastoma Japan (Kyoto Upiyc,.ity Hosnilli) - Nephroblastoma, blastema! type Saydi Arabia (Kint; Ahdulaziz Medical Cjty Group\ • Wilm's tumor United Kipgdom (John Badcliffe Hospital) • Neplu'oblastoma Oman ISul!anat of Oman) • Wilm's tumor

C!st 3 • Diagnosis: Wilms tumor, kidney

T-71000, M-89603

Case; 3 ~ References:

Hohenstein P and Hastie ND. The Many Facels of the Wilms' Tumour Gene. Hum Mol Genet 2006; 15 Spec No.1: Rt96-201.

Hamilton TE, Green OM, Perlman EJ, et al. Bilateral Wilms' Tumor with Anaplasia. Lessons From the National Wilms' Tumor Study. J PediatrSurg2006; 41(10):1641-1644.

Suita S, Kinoshita Y, et a!. Oinieal Characteristics and Outcome of Wilms Tumors with a Favorable Histology in Japan. A Report From the Study Group for Pediatric Solid Malignant tumors in the Kyushu Area, Japan. J Pediatr Surg 2006; 41(9):150'1-1505.

Dome JS, Cotton CA, Perlman EJ, et a:I. Treatment of Anaplastic Histology Wilms' Tumor. Result~ From the Fitlh National Wilms' Tumor Study. J Clin Onco/2006; 24(15):2352-2358.

Metzger MLand Dome JS. OJrrent Therapy for Wilms' Tumor. Oncologi.st2005; 10(10):815-826.

Case No. 4, Accession No. 30499

Alame!la (Alameda Coy my Mcdjca! C'.entcr) • Clear cell sarcoma Ar<:;ldia (ABC Laboratories\ • PNET Foota0a (Kaiser Permancn!cl • PNET/Ewing Hayward/Fremont • Wilm 's tumor La Jolla (Scrip.ps Oinic) • Oear cell sarcoma LoDII Bcacb (Long Beach veterans Hospital) • Malignant small blue cell tumor (7) Mountain View (Ill Camjno Hospital) • Clear cell sarcoma of kidney Oakhmd · Wilm's tumor On!DQC (Ora01\e County Pathology) • Clear cell sarcoma Oxnard (St. John's Rcgipna! Medical Cente!) - Wilm's (2); Oear cell sarcoma (1) San Diego (Naval Medical Center) - Oear cell sarcoma Sap Picgo (RCRMQ - Nephroblastoma Sap frnncisco (YCSF Fcl!pw:;,) - Oear cell sarcoma of kidney Sap Francisco (San Franciw General Hospital) • Neuroblastoma SaPia Barbara - Nephroblastoma San1a Barbara (Cottage Hospital) - Small blue cell tumor, NOS

February 2008

San1a Rosa (Santa Rosa Memorial Hospital) • Sarcoma, probable clear cell type (1); Clear ceU sarcoma of kidney (2) Spnoma - Nephroblastoma

C'll'R. f,.bnwy 2008 "Millul..- (Suboaiption A) 7

Alabama (:Baptjst Medical Center) - Clear cell sarcoma Alabama. Mt. O!!ve - Neuroblastoma Colomdo (McKee Medical Center) - Clear cell sarcoma of ~idncy Florida Cfallabnssee Patholnn Alisociates) - Clear cell sarcoma Georgia Decatur ·Clear cell sarcomaofkidoey Illinois. Burr Ridge • Wilm 's rumor U!inois (lic.lnlapd Regional Mcs!ical Center) - Clear cell sarcoma, epithelioid pattern Indiana (MacNeal Hosni!ll!) - Clear cell sarcoma vs. WUm's tumor, blastema type Indiana (SI, Joseph Hosoital) • Extrskeletal Ewing's sarcoma (1); Wilm's tumor (1) Kansas (Cytocbe&k L.aboratory) • Rhabdoid tumor (2) Louisiana (Qrlcaas Parish Coroner's Office) - Wilm's tumor Massachusetts (Berkshire Medical Center) . Clear cell sarcoma Massachusetts Cfufts-New England Medical Center) - Neuroblastoma MassachuscUs (UMASS Memorial Me!lical Center) - Clear cell sarcoma of kidney Michigan Q'atholoay Services of West Michigan) - Wilm's tumor Minnesota (fajrvjcw Ridges Hosoita!) - Clear cell sarcoma of kidney Nebraska (C«<jgh[on University Medical Center) . - Clear cell sarcoma New Mexico (Aibuqucrq~ - Clear cell sarcoma New Mexico (University of New MexiCQ) - Clear cell sarcoma New York CECMQ - Clear cell sarcoma New York O.On~ Island Jewish Medical Center) - Clear cell sarcoma New York (Stony Brook Unjversitv Medical Center) - Clear cell sarcoma Ohjo (McCullough-Hyde Memorial Hosnilal) - Clear cell sarcoma Pcgnsylvanja (Conmauah Memorial Ho.<pital) - aear cell sarcoma Pennsylvania CPrcxe! Mcs!ica! Center) - Clear cell sarcoma of the kidney Pengsylvanja Cl.cbi~b Valley Hospital) - Qear cell sarcoma of kidney Pennsyly;mja (Magee Women's Hospital) - Qcar cell sarcoma Pcnnsylynoja CSt. B!izahctb Health Center) - Wilm 's tumor, blastema! predominant Tennessee (P..ast Tennessee State UniversiO:) - NeuJoblastoma Tcx(IS. Crys!nl Beach - Small cell carcinoma (neuroendocrine?) Texas, Hous!on - Clear cell sarcoma Texas. Lubbock - Neuroblastoma Texas (Scot! & Whjte Memorial Hospital) - Clear cell snrcoma Texas Cfbc Mctbodjst Hnspit;U) - Ewing sarcoma Washinaton (Seanle VA Medical Center) - High grade neoplasm, uterus West Yirajnja (Greenbrier Vallcv Medical Centc[) - Neuroblastoma Austr.!lia (Roval Hoban Hospital) - Clear cell sarcoma of kidney Brazil. Sao Paulo - Small blue round cell tumor, favor neuroblastoma Canada (PasQua Hospital) - Clear cell sarcoma Canada lJ.Inivc!l!ilv Hospital Sberbrooke) - Neuroblastoma Hong Kong (Hong Kong Baptist Hospital) - Clear cell sarcoma of kidney Ireland (Kcrrv General Hospital) - ? WJ!m's tumor Ireland (Unjycrsity <Allege Hospital) - Neuroblastoma, kidney Jaoon £A5ashi General Hospital) - Primitive neuroectodermal tumor Japan (Kvo[o Unjycrsjty Hospital) - Clear cell saroomn Saudi Arabja (Kina Abdulaziz Medical a ty Grou!l) - C!cnr'ccll sarcoma Uni)ed Kinsdom (John Radcliffe. Hospital) - Nephroblustoma Qman (Sy!Jannt of Oman) - Clear cell sarcoma

Case 4- J)Jagnosjs; Clear cell sarcoma, kidney

T-71000, M-90443

Case 4 • References: Ng A, Jenkinson H, Morland B, et al Oear CclJ Sarcoma. A Dilemma on Patbologicol Staging and Clinical Management. Proiatr

Ht!matol Onco/2005; 22(3):257-261.

8 CITR. February 20118 "Minutes" (Subscription A)

Rakheja 0, Weinberg AG, Tomlinson GB, eL al. TranSlocation (10; 17) (q22; p!3). A Recurring Translocation I aear Cell Sarcoma of Kidney. Cancer Genet cytogenet2004: 154(2):175-179.

Argani P and Ladanyi M. Recent Advances in Pediatric Renal Neoplasia. AdvANJJ PaJho/2003; 10(5):243-260. Raclhika S, Bakasbi A, Rajwanshi A, et al. Cytopathology ofUn¢0mmon Malignant Renal Neoplasms in the Pediatric Age Group.

Diagn Cytopatho/2005; 32(5):281-286. El Kababri M, Khattab M, E1 Kborassani M, ct al. Clear Cell Sarcoma of the Kidney. A Srudy of 13 O.ses. Arclo Pediotr 2004;

11(7):794-799.

Case No. S, Accession No. 30676 February 2008

Alameda (Alame!la Coynty Medical Center) - Oncocytoma Arcadia (ABC Lahora!Ories) - Oncocytoma (oncocytoma adenoma) Fonlana (Kaiser Pcrmanente) - Oncocytoma Hayward/Fremont • Oncocytoma !.a Jolla (Scripps Clinic;) • Oncocytoma Long Beach IJ.ong Beach Yeternns Ho:;pital) ~ Oncocytoma (7) Mountain Vjew (EI Camjpo Hospital) • Oncocytoma Oakland • Oncocytoma Omnge (.Orange County Palholo!O') - Oncocytoma Oxnard (St. John's Regjonal Medical Center) • Oncoctyoma (3) San Djcgo (Naval Medical Center) - Oncocytom" San Diego (RCRMQ) • Oncocytoma San FrancjSC<> (l.JCSF Fellows) • 0nCOC)10ma San Francisco (San Francisco General Hospital) • Oncocytoma Santa Barbara - Oncocytoma San1a Barbara (Conage Hospital) - Renal oncocytoma Snola Rosa (Santa Rosa Memorial Rosoital) - Oncocytoma (3) Sonoma - Oncocytoma Alabama (l3aptist Medical Center) - Renal oncocytoma Alabqma. Mt. Oljye - Oncocytoma Colorado (McKee Medical Center) - Renal cell carcinoma, chromophobe type Florida O'allahassec Pa(holoQy AssociateS) - Oncocytoma Georgia . Decatur - Oncocytoma D!joojs. Burr Rid!~' - Oncocytoma ll!jnojs Q!eartland Rcaional Medical Center) - Oncocytoma lndjana (MacNeal Hosnjtal) - Oncocytoma lodjana (St Jo,;cph Hosni!nl) • Renal oncocytoma (2) Kansas (Cytocheck Laboratory) • Oncocytoma (2) Loyjsjana (.Orleans Parish Coroner's Office) • Onocytoma M••••ohusens (l3erkshjre Medical Center) • Oncocytoma Massybusctts (J\!fts-Ncw Ensland Medical Centct) • Oncocytoma vs. chromophobe renal cell carcinoma Massashusctts (lJMASS Memorial Medical Cen1e!) • Oncocytoma Mjchjsap (Pathology Scrvjces of West Michigan) • Renal ceU carcinoma Mjnpesom (Fairview Ridges Hospital) - Oncocytoma Ncbmska (Creighton University Medical Centec) • Oncocytoma New Mexico (Aibuqucr~ • Oncocytoma New Mexico (.University of New Mexico) - Oncocytoma New York (ECMQ) - Oncocytoma New York (J.ong Island Jcwjsh Medical Ccntc!) - Oncocytoma New York (Stonv Brook Upjyersity Medical Ccmcr) • Oncocytoma Ohjo (McCullough-Hyde Memorial Hosphal) - Renal oncocytoma Pennsylvania (ConmauRh Memorial Hospital) • Oncocytoma Pennsylvania (Drexel Mcdjcnl Center) - Oncocytoma Pennsylvania (Lehigh Ynlley Hospital) - Oncocytoma Pennsylvania (Magee Women's Hosoital) - Oncocytoma Pennsylvania (Si. Eljzahelh Health Cenlec) • Renal oncocytoma

9

IGnnc.•scc (EaS! Tennessee State University) - Oncocytoma Texas. Crvstal Beach - Oncocytoma Thxas. HoySion - Oncocytoma Tci!llS. Lubbock - Oncocytoma Texas CScou & White Memorial Hospital) - OncocytortUI Texas ITbc Mc(hodist H~ital) - Oncocytoma Wa@ington CScanle VA Medical Ccntq) - Low grade epithelial neoplasm, oncocytoma Wcs! Vimjnja (Qrecnbrier Vallev Medical Center) - Oncocytoma Austra!jp (Royal Robart Ho~ital) - Oococ}1oma Brazj!. Sao Paylo - Oncocytoma Canada Q'asqua Ho~ital) - Oncocytoma Canada (Unjycrsitv Hospital Sherbrookc) - Oncocytoma Hona Kona (Hong Kong Baptist Hospital) • Renal oncocyloma Ireland (Kerry General Hospital) - Oncocytoma Ireland (JJnivcrsity College HosP.ital) • Oncocytoma, kidney Japan (AsW!hi Gcncrnl Hospital) - Oncocytoma Japgo (Kyoto Unjyersjty Hospital) - Oncocytoma . Saudi Arabja (King Abdulaziz Medical Citv Groull) - Oncocytoma United Kinadom (lohn Radcliffe H~ital) • Oncocytoma Oman (SultaMt of Oman) - Oncoc}1oma

Case 5 • pjagnosi<: Oncocytoma, kidney

T-71000, M-82900

Qs; 5 • References: Wunderlich li, liindennan.n W, AI Mustafa AM, et al. The Accuracy of250 Fine Needle Biopsies of Rcoa11'umol'$. J Uro/2005;

174(6):2422. cavc:olin·l Immunohistochemical Analysis in Differentiating Chromophobe Renal Cell carcinoma from Renal Oncocytoma. AmJ

Clin Pot/w/2006; 125(3):392-398. AI·Salocm T, Calms P, Dulaimi EA, e1 al. The Genetics of Reno I Onooeytosis. A Possible Model For NeopiU$tiC Progression.

Cm«cr Ga,wt Cyrogef11Jt2004; 152(1):23·28.

Case No. 6, Accession No. 30703

Alameda (Al;•mcd;l County Medical Center) - Renal cell carcinoma, high-grade Arcadia (ABC yboratories) - Oncocytic C3Icinoma Ponlana (Kaiser Pennanegt~ - Transitional cell carcinoma Hayward/Fremont - Renal cell carcinoma, Fuhrman, grnde IV La Jolla (Scripps Oinic) • Grade IV renal cell carcinoma, favor chromophobe type

February 2008

Long Beach (Long Beach Veterans Hospital) - Poorly differentiated maligrulnf neoplasm favor high grnde trnnsitional cell carcinoma (2)

Mountain View Cfl Camino Hospital) - Renal cell carcinoma, grade 3, granular cell type Oakland • Renal cell carcinoma(? Adeoosquamous) OranAA (Orange County Pathology) - High grade carcinoma Oxnard (St. John's Regional Medical Center) - Renal cell carcinoma, granular type (2; Oncocytoma (1) San pjego (Naval Medical Center) • Urothelial carcinoma San Diego (BCRMG) - Renal cell carcinoma, chromophobe type Sup Francisco (UCSP Fellows) • Urothclial carcinoma San Francisco (San Frnneisco General Hospital) - Chromophobe renal cell carcinoma Santa Barbara - Renal cell carcinoma Santa Bnr!mm (.Cottage Hospital) • Transitional cell carcinoma, high grnde San}a Rosa (Sama Rosa Memorial Hospital) - Transitional cell carcinoma (1); Renal cell carcinoma with

comcdonccrosis (2) Soooma - Ocar cell carcinoma, grade IV

10 CITR, February 2008 "~linulcs" (Subscriplion A)

Alabama (Baptist Medical Center) - Renal cell carcinoma, chromphohe Alabama. MI. Olive • Urothelial carcinoma, high grade Colorado (McKee Medical Center) - Carcinoma with neuror:ndocrine features, possible adrenal origin Florida (Tallahassee Pathology Associate§) • High grade urothelial carcinoma Georgia Dceatur - Renal cell carcinoma, not otherwise specified (with rhabdoid cells) !llinois, Burr Ridge - Renal cell carcinoma with clear cell features Dlinois (Heartland Regional Medical Ceptec) • Poorly differentiated carcinoma, favor urothelial carcinoma Indiana (MacNeal Hosoital) - Collecling duct carcinoma vs. high-grade urothelial carcinoma ln!liana (St. Joseph Hosoital) - Renal cell carcinom'l, granular cell variant (1); High grade renal cell carcinoma, rule

out melanoma (1) Kansas (Cytocheck Laboratoo(l - Metastatic carcinoma (1 ); Renal cell carcinoma, grade IV (1) Louisiana (Orleans Parish Coroner's Office) • Chromophobe cell carcinoma Ma.'l.<achusetts (llerkshire Medical Center) • High grade carcinoma, favor chromophobe Ma.<;,<achusetts (Tufts-New England Medical Center) • Collecting duct carcinoma Ma.<;,~achusetts (YMASS Memorial Medical Center) • Unclassified high grade renal cell carcinoma Michigan (pathology Seooccs of West Michigan) - Renal cell carcinoma Minnesota (fairyiew Ridges Hospital) • Renal cell carcinoma, clear cell type Nebraska (Creighton University Medical Center) - Collecting duel renal cell carcinoma New Mexico (Albuquerque) • Papillary renal cell.carcinoma, type 2 New Mexico (.University of New Mexico) - High-grade renal cell carcinoma, NOS New York (!l.CMG) • Clear cell carcinoma with sarcomatoid features New York (Lon~ Island Jewish Medical Center) - High grade renal cell carcinoma, NOS New York (Stony Brook University Medical Center) • Malignant neoplasm, NOS Ohio (McCullqugh-Hyde Memorial Hospital) - Chromophobe renal cell carcinoma Pennsylvania (.Conmaugh Memorial Hospitai) - Renal cell carcinoma, clear cell type, Fuhrman, grade N Pennsylvania Q)rcxel Medical Center) - Renal cell carcinoma with rhabdoid differentiation Pennsylvania (Lehigh Valley Hospital) - Collecting duct carcinoma Pennsylvania (Magee Women's Hospital) • Renal cell carcinoma, clear cell, eosinoplillic variant Pennsylvania (St. Elizabeth Health Centec) • Renal cell carcinoma, high grade Tcnnes.~ee (Bast Tennessee State Uniyersjty) • Undifferentiated carcinoma Tcxa.<, Crystal Beach - Renal cell carcinoma, chromophobe cell Texas Houston - Carcinoma, possible transitional cell carcinoma cannot rule out chromophobe Tcxa.~. Lubbock - Chromophobe carcinoma Tcxa.~ (Scott & White Memorial Hospital) • Renal cell carcinoma, clear cell type Texas (The Methodist Hospital) - Clear cell renal cell carcinoma (nuclear, grade IV) Washington (Seattle VA Medical Cente[) • Renal cell carcinoma, high grade cytology West Virginia (Greenbrier VaJI~;y Medical Center) · Renal cell carcinoma Australia (Royal Hobart Hospilal) • High grade urothelial carcinoma Brazil_ Sao Paulo • Clear cell carcinoma vs. epithelioid angiomyolipoma Canada (Pasqua Ho§l!ita!) • Clear cell carcinoma Canada (University Hospital Shcrbrooke) - Clear cell carcinoma Hong Kong (lions Kong Baptist Hospital) - Poorly differentiated carcinoma (collecting duel carcinoma) Ireland (Kerrv Gegeral Hospital) • Renal cell carcinoma, ? collecting duct type Ireland (Yniyersjty C'..olle~c Hospital) - .Oncocytoma variant renal cell carcinoma Japan (Asashi General Hospital) - Renal cell carcinoma, clear cell type Japan (Kyoto University Hospital) - High grade renal cell carcinoma (Ghromopbobe? or unclassified) Saudi Arabia (King Abdulaziz Medical Citv Groufll · High grade carcinoma, probably urolhclial carcinoma United Kingdom (John Radcliffe Hospital,) - High grade carcinoma, possibly transitional cell) Omap (Sultan at of Oman) · Renal cell carcinoma unclassified; DDx: Transitional ce.IJ carcinoma

Case 6- Diagnosis: Poorly differentiated renal ceU carcinoma with granu.lar cell features, kidney

T-71000,M-83123

Ca<e 6 • References: Garcia E and LiM. Caveolin·l Immunohistochemical Analysis in Differentiating Chromophobe Renal CeU Carcinoma from Renal

Oncocytoma. Am J Clin Palhol 2006; 125(3):392-398.

cri'R, february 2008 "Minu1es• (SUbocrlplion A) u

llob T, Chikai K, Ota S, eta!. Chromophobe Renal Cell Carcinoma with Osteosarcoma-like Differentiation. Am J Surg Parllol 2002; 26(10): 1358-1362.

Lohse CM and Cheville JC. A Reivew of Prognostic Pathologic Features and Algorithms for Patients Treated Surgically For Renal Cell Carcinoma. Clln Lab Med 2005; 25(2):433-464. •

Baroeas DA, Robnn SM, Kao I, eta!. Diagllosis of Renal Tumolll on Needle Biopsy Specimens By Histological nnd Molecular Analysis. J Uro/2006; 176(5):1957-1962.

Perez-Moo tiel D, Wakely PE. Res 0, et al. High-Grade Urothellal Carcinoma of the Renal Pelvis. Clinkopatbologjc Study of 108 Cases With Emphl5is on Unusual Morphologic VarinniS. Mod Parho/2006; 19(4):494-503.

Case No. 7, Accession No. 30681

Alameda (Alameda County Medical Center) - Renal cell carcinoma, papillary Arcadia (ABC L.abomtodes) - Clear cell adenoma, rule out early carcinoma Fontana (Kniscr Pcrmancnt<l) - Papillary renal cell carcinoma Hayward/fremont - Papillary renal cell carcinoma La Jolla (Scrjnps Qjnjc) - Renal cell carcinoma, papillary type Long Beach (Lon a Jkacb veterans Hosoital) - Renal papillary cell carcinoma (7) Mountain Vjew (El Camjno HospitaD - Papillary renal cell carcinoma Oakland - Carcinoid Oranoe COnlQge County Pathology) - Renal cell papillary carcinoma Oxnard CSt. John's Reaiopal Medical Center) - Renal cell carcinoma, granular cell type (3) San Pic•o CNml Mcs!ical Center:) - Papillary renal cell carcinoma San pjeoo CRCRMC) Papillary renal cell carcinoma San Francisco (UCSF Fellows) - Papillary renal cell carcinoma Sao Frapcisco (SM Franci= Genera] Hospital) - Collecting duct renal cell carcinoma Santa Barbara - Metanephric adenoma Santa Barbara (Qmage Hospital) - Papillary renal cell carcinoma

February 2008

Santa Rosa (Sapta Rosa Memorial Ho:;pjtal) - Papillary carcinoma of kidney (1); Papillary renal cell carcinoma, type I (1); Papillary renal cell carcinoma (1)

Sonoma - Papillary renal cell carcinoma, grade I Alabama (»aptiSI Medical Center) - Renal cell carcinoma, pupillary Alabama, MJ. OHye - Pap.illary renal cell carcinoma Colorado (McKee Medical Center) - Papillary renal cell carcinoma Florida (l'aUabassee Pathology A<sociates) - Low grade urothelial carcinoma Geor!Pa , Decatur - Papillary renal cell carcinoma illinois. Burr Rid&e - Renal ceU carcinoma, papillary lllioois (Heanlaru! Reaional Medical Center) - Papillary renal cell carcinoma Indiana (MacNeal HOSf!ita!) - Papillary renal cell carcinoma lndiMa (St. Jo:;<;ph Ho$12iW) - Papillary renal cell carcinoma (1); Renal cell carcinoma, grade Jl (1) Kansas (Cyloeheck Laboratory) - Papillary renal cell carcinoma (2) Louisiana (Qdeans Parish Coroner's Office) - Tubulopapillary adenoma Massachuseus (Bcrkshjrc Medjcal Center) - Papillary renal cell carcinoma, type I Massachuseus (J'ufts-Ncw England Medical CentcJ:) - Papillary renal cell carcinoma Massachuset)s (UMASS Memorial Medical Center) - Papillary renal ceU carcinoma Michigan (Patholocy Scrvjces of West Michigan) - Rcnul cell cJireinoma, papillary Minnesota (.Fajrvjcw Ridccs Hospital) - Reoal eel) carcinoma. pupillary Nebrdsku (Crcigluon University Mcdjcal Cenler) - Papillary renal cell carcinoma, type r New Mexico (Albuquerque) • Papillary renal cell carcinoma, type T New Mcxjco (\JnivCL~ily nf New Mexico) - Papillary renal cell carcinoma, type I New York (ECMC) - Papillary renal cell carcinoma New York (Long Island Jewish Mec!jcal Center) - Papillary carcinoma, type I New York ($1ony Brook University Mec!ical Center) - Papillary renal cell carcinoma, type I Ohio (McCullouch-Hyde Memorial Hospital) - Papillary renal cell carcinoma Pcppsylvania (Conmaugh Memorial Hospjlal) - Renal ceU carcinoma, papillary type, type I

·remwrlyanja (Drexel Medical Center) - Papillary carcinoma Pegpsv!yaoja (Lehigh Vallev Hospital) - Papillary renal cell carcinoma

12 CITR. Febtual)l2008 "Minutt$" (Subscription A)

Pennsylvania (Magee W9men's Hos~ital) • Papiliary renal cell carcinoma, type I Pennsylvania (St. Elizal>etb Health Center) • Papillary renal cell carcinoma, (bastophilic type) Tennessee (East Tennessee State UniversitY) • Papillary type renal cell carcinoma Texas, Crystal Beach - ~coal eel) carcinoma, papillary Texas, Houston • Papillary renal cell carcinoma Texas. Lubbock - Papillary renal cell carcinoma Texas (Scott & White Memorial ffospital~ • Papillary renal cell carcinoma Texas O'he Methodist Hospital) • Papillary renal cell carcinoma, type I WashjngjQQ (Scattle:V A Medical Center) • Papillary renal cell carcinoma West V!r~nia (Greenbrier Valley Medical Center) - Papillary adenoma Australia (Royal Hobart Hospital) - Papillary renal cell carcinoma, type 2 Brazil Sao Paulo • Papillary carcinoma, type 1 Qmada (Pasqua Hospital) • Papillary carcinoma Qmada (University Hospital Shcrbrooke) · Papillary carcinoma, type I Hon~ Ron~ Qiong Kong Baptist Hospital) · Papillary renal cell carcinoma .Ireland (Kerry General Hospital) · Papillary renal cell carcinoma Ireland (Yniversity College Hospital) · PapiUary renal cell carcinoma Ja an Asashi General Hos ital • Papillary renal cell carcinoma, type I Ja an K oto Universit Ho ita! · PapiUary renal ceO. carcinoma, type I Saudi Arabia (King Abdulaziz Medical City Group) • Papillary renal cell carcinoma United Kingdom (John Radcliffe HosP.ill!J.). - Papillary renal cell carcinoma, type 1 Oman (Sultan at of Oman) - Papillary renal cell carcinoma

Case 7 • Diagnosis: Papillary renal cell carciooma

T-71000, M-83123

Cruie 7 - Reference~; Lim JC and Wojcik EM. Fine-Needle Aspiratlon Cytology of Papillary Renal Cell Carcinoma. Tho Association with Concomitant

SecOndary Malignancies. Diagn Cytopalho/2006; 34(12):797-800. Yamana)<.a K, Miyake ll, Hara ~ et al. Papillary Renal Cell Carcinoma. A Clinioopathological Study of35 Cases. lnt J Uro/2006;

13(8): 1049-1052. Hoglund M, Gisselssoo D, Soller M, et al. Dissecting Karyotypic Pauemsin Renal Cell Carcinoma. An Analysis of the

Accumulated Cytogenetic Daf1l. Cancer Genet Cytogenet2004; 153(1):1-9. Reuter VE. The Pathology of Renal Epithelial Neoplasms. Se.mi11 Onco/2006; 33(5): 534-543.

Case No. 8, Accession No. 30563 February 2008

Alameda (Alameda O>unty Medical Center) · SmaU cell carcinoma Arcadia (ABC Laboratories) · Small cell anaplastic carcinoma, possible ncuroendocrio.c differentiation Fontana (Kajser Pennanente) · Small ceU neuroendocrine carcinoma Hayward/Fremont • Small cell carcinoma La Jolla (SQriPJ.'" Clinic) · Poorly differentiated smaU cell carcinoma Loni Beach (Long Beach Veterans Hospital) · SmaU ceU carcinoma(!) Mountain View (EI Gamino Hospital) - Small ·ceU neuroendocrine carcinoma Oaklanil - Small cell carcinoma Orange (Orange County Pathology) · Small cell poorly differentiated carcinoma Oxnard <St. John's Regional Medjcal Cemer.) • Small cell carcinoma (3) San Diego (Naval Medical Cente() - Small cell carcinoma San Diego (RCRMG) - Small ceU carcinoma, bladder San Francisco (YCSF Fellows) - SmaU cell carcinoma San Francisco (San Francisco General Hospital) • Small cell undifferentiated carcinoma Santa Batbara - Small ceU carciooma Santa Barbara (ConageHosll.itill) • Neuroendocrine carcinoma, giade Ill, small cell Santa Rosa (Santa Rosa Mcmprjal Hpspjtal) • Neuroendocrine carcinQma vs. large cell lymphoma (1); Small ceU

anaplastic carcinoma (2)

CJ.1.'R., Fcbroary 2008 "Minutes" (Subscription A) l3

Sonoma - Poorly differentiated small cell carcinoma of bladder Alabama (Baotist Medical Center) - Small cell carcinoma Alabama. Mt. Olive - Small cell carcinoma Colorado (McKee Medical C'&ntet) - Small cell carcinoma Florida Q'allabasge Pathology Assor.iatcs) - Small cell carcinoma Georgia . Oec;arur - Small cell carcinoma Illinois. Burr Rjdge - Small cell carcinoma Illinois ()i!!!!nlapd Regional Medical Center) - Small cell anaplastic carcinoma Indiana (MacN!!!!l Hospital) - Small cell carcinoma Indiana (SJ. Joseph Hosoital) • Small cell carcinoma (undifferentiated carcinoma) (1); Neuroendocrine carcinoma vs.

lymphoma {I) Kansas (Cytochcck Laboratory) - Poorly differentiated small cell carcinoma (2) Louisiana (Qrlc!!ns Parish Coroner's Office) - Small cell carcinoma Massachuseus (Berl<sltire Medical Center) - Small cell carcinoma Massachuscus (]\tfts-New England Medical Cente!) - 1-ligb grade transitional cell carcinoma Massachuseus (UMASS .Memorial Mgljcal Center) - Small cell carcinoma of bladder Michigan O'a)holo~~:y Services of West Michigan) - Small cell carcinoma Minnesota (Fairview Ridges Hospital) - Small cell carcinoma Nebraska. (.Creighton Upiversity Medical Center) - Small cell carcinoma of bladder New Mcxjco (Albuquerque) - Small cell carcinoma New Mexjco (University of New MexiCQ) - Small cell carcinoma of the bladder New York CECMC) - Poorly differentiated small cell carcinoma New York Q.ong L•land Jewish Medical Centec) - Small cell carcinoma New York CStony Brook Ugiyersity Medical Center) - Small cell urothe!iaJ carcinoma Ohio (McCullough-Hyde Memorial Hospital) • Small cell carcinoma Pcnnsy!yaoja (Q)omauih Memorial Hospital) • Small cell carcinoma Pcnnsyl yaoja £Drexel Medical Center) - Small cell carcinoma Pennsylyanja Q.chigh Valley Hospital) - Small cell carcinoma Pennsy!ynnja (Magee Women's Hospital) - Small cell carcinoma Pennsylyanju (St. Elizabeth Health Center) - Smull cell carcinoma Tennessee (BaSI Tennessee State University) - Small cell carcinoma Texas. Crystul Beach • Ctrcinoma bladder small cell (neuroendocrine?) Texas. Houstoa - Small cell carcinoma Texas. Lubbock - Small cell carcinoma Texas (Sco\1 & White Memorial Hospital) - Small cell carcinoma Texas Q'be Methodist Hospital) - Small cell c-.ucinoma Washinaton £Seanle VA Medical Center) - Malignant neoplasm, high grade (stem cell), cytology West Virajnja CGn:cnbrier VaUcv Medical Center) - Poorly differentiated small cell carcinoma Ausua!ia (,Roval Hoban HC!Stlital) - Small cell carcinoma Brazil. Sao Paylo - High grade urothe!iaJ carcinoma with differentiation to neuroendocrine small cell carcinoma Canada (l'asqya Hospital) - SmaU cell carcinoma Canada OJnivcrsilv Hospital She!brooke) - Small cell carcinoma Hong Kong (Hons Konc Baptist Hrn;pitaU - Small cell carcinoma frcland CKerrv General Hospital) - Small ceU carcinoma of bladder Ireland (University College Hospital) • High grade neuroendocrine ltlmor ll!pap (1\sqshj General Hospital) - Small cell carcinoma Japap CKyo\O Uniycrsily Hospital) - Neuroendocrine carcinoma Saudi Arabja (Kin~ 6bdulaziz Medical Gty GrouQ) - Small cell carcinoma Unilcd !Gpgdom (John Radcliffe Hospital) - Small cell carcinoma(? metastasis) Oman (Sul!apa! of Oman) • High grade invasive urothelial carcinoma; DDx:Small cell carcinoma

Case 8 . Pjugnosis; Small cell carcinoma, bladder and prostate

T-77100, M-80413

Osr 8 . Refereng;.t: Cburdl ON and Dahl A Clinical Review. Small Cell Carcinoma of the Bladder. CancuTreJJJ Rev2006; 32(8):S88-S93.

14 CJTR. FebruaJ)' 2008 "Mlllulco" (Subscriplion A)

Montie lB. Small Cell Carcinoma of the Urinary Bladder. A Clinicopathologic Analysis of 64 PatieoiS. J Uro/2005; 173(6):1920· 1921.

Oleng Land Jooes lD. Molecular Genetic Evidence for a Common Clonal Origin of Urinary Bladder Small Cell Carcinoma and Coelristiog Urothclial Carcinoma. AmJ Ptl1ho/200S; 166(5):15!3-1539.

Helpap B. Morphology and Therapeutic Strategies for Neuroendocrine Tumors of the Genitourinary Tract. Cancu 2002; 22(1):88-104.

Case No. 9, Accession No. 30721 February 2008

Alameda (Alameda County Medical Center) - Papillary urothc!lul carcinoma, low grade Arcadia (ABC laboratories) - Moderately differentiated papillary urothelial carc.inoma Eon !ana (l<aiser Pennanente) - TraiiSilional cell carcinoma Hayward/Fremont . Transitional cell carc.inoma, low grade l.a Jolla <Scripps Clinic) - Papillary urotbclial carcinoma, low grade Lon; Beach (!.ong Beach Ye.ternns Ho.1pital) - Papillary urothelial carcinoma (7) Mountain Yiew (El Dmino Hosl!iJaO • Low-grade papillary urothclial carcinoma Oakland - Inverted papilloma (vs. low grade carcinoma) Orange (Orange County Patholo~y) - Transitional cell carcinoma Oxnard (St. John's Regional Medical Center) - Transitional cell carcinoma (1 ); Papillary transitional neoplasm of low

malignant potential (2) San Piego (Naval Medical Center) - low grade papillary urothclial carcinoma San Piego (RCRMC) - Transitional cell carcinoma, low grade San francisco (YCSF Fellows) • Papilloma San Fmgs;j§f!) (San Fmncisco Geneml Hospital) • Low grade papiUary urothelial carcinoma Santa Barbam • .low grade papillary urothelial carc.inoma Santa Barbam (Cotta&e Hospital) - Papillary urothclial carcinoma, low-grade Santa Rosa (Santa Rosa Memorial Hospital) - Tmnsitiona! cell carcinoma, grade 1/TU (1); Non-invasive papillary

urothclial carcinoma, low-grade (2) ~1 - Papillary urothelial carcinoma, low-grade Alabnma (13aptist Medical Center) • Papillary urothe!ial carcinoma, low-grade Alabama, MI. Olive • Low-grade papillary urothelial carcinoma, non-invasive Coloradq Qv!cKee Medical Center.) - Low-grade papillary urothelial carcinoma F!odda (Iallahassee Pathology Associate§) - low-grade urothelial carcinoma Gmraia , Pccatur • Papillary urothclial carciooma, high-grade !l!inois, Burr Ridge · Papillary transitional cell carcinoma Dlinois (Heartland Regional Medical O:n1cr) - Low-grade urothelial carcinoma Indiana (MacNeal Hospital) · Urothelial carcinoma, grade Ito 11 Indiana (St. Joseph Hospi!al) · Papillary urothelial carcinoma, tl"Jnsitional cell carcinoma, low-grade Kansas (Cytocheck laboratory) - Transitional cell carcinoma (I); Low-grade urothelial carcinomn (1) IAuisiana (Orleans Pa.rish Coroner's OffiC!l) - Papillary transitional cell carcinoma, grade I Massachusetts (13erkshire Medical Ccnte(l - UCothelial carcinoma, low grade Massachusetts Cfyfls-New En~ land Mec!jcal Cent«) - Transitional cell carcinoma Ma:;.~chusetts (UMASS Mcmorjal Medical Center) - Urothclial carcinoma, low-grade Michi!!1!n (pathology Service!! of West Michigan) - Transitional cell carcinoma 1/ITI Minnesma (fairview Rjdgcs Hosnitol) - Papillary urothclial carc.inoma, low-grade Ncbra.•ka CCreightop Univc.,;ity Medical Cented - Urothclial carc.inoma, low-grade New Mexico (Aibuqueroue) - Papillary urotbclial carc.inoma, low-grade New Mexico (.University of New Mea;jeo) - Non-invasive low-grade papillary carc.inoma New York (ECMC) • Urothelial cell carcinoma New York (I.ong Island Jewish Medicnl Center) • Urothelial carcinoma, low-grade New Ymk (Stony Brook University Medjcal Center.) • Papillary urothcllal carcinoma, low-grade, non-invasive Ohio (McCullough-Hyde Memorial Hosl!iJaO - Low-grade urothclial carcinoma Pcnnsylyapia (Conmaugh Memorial Hospital) • Non-invasive papillary urothelial carcinoma, low-grade Pcnosylyapja (Prexel Medical Ceptcr) - Transitional cell carcinoma, low-gmdc Peposylvapia (Lehigh Valley Hospilal) • Papillary transitional cell carcinoma of low grade Pcnn'YIY110ia (Magee Women's HO$iUiiO - low-grade papillary urotbclial carcinoma

Cfl'R, FcbNaty 2008 "Minutes" (Sabscriprioa A) IS

Pennsylvania (St. .Elizabeth Health Center) - Low-gmdc papillary urothelial carcinoma Tennessee (East Tennessee State University\ - Low-grade papillary urothelial carcinoma Texas. Crystal Beach - Urothelial papillary tmnsitiooal ceU carci,noma Texas. Houston - 1'apillary tumor of uncertain malignant potential Texas. Lubbock - Low-grade papillary carcinoma ~ (Scott & White Memorial Hosoital) - Low-grade non-invasive papillary urothelial carcinoma Texas (Ihe Methodist Hospital) - Papillary urothelial carcinoma, low-grade Washington (SeattleVA Medical Center) - Papillary urothclial neoplasia, low-grade cytology, invasive growth not

evident · West Virginia (Qreegbrier valley Medical Center) - Uothelial carcinoma, papiJiary Australia (Royal Hobart Hospjta!) - Low-grade ur6thelial carcinoma BraziL Sao faylo - Low-grade papillary urothelial carcinoma (3); PUN.LMP (2) r..anada O'asqpa HQ~Jlltal), - Urotbelial carcinoma, low-grade Canada (!Jniyersjty Ho;;pital Sherbrooke) - Papillary neoplasia, low-malignant potential Hnn~ Knn& (Hong K<lng .!!aptist Ho§oila!), - Papillary urothelial tumor of low malignant potential Ireland (Kerry Gcncml Hospital) - Transitional cell carcinoma of bladder Ireland (!Jnivci'Sity Oillc~c Howital) - Papillary urothelial carcinoma Japan (A.<a.•hi General Ho!!Pilal) - Urothelial carcinoma with inverted growth pattern Japan (Kyoto University Hospital) - Urothelial carcinoma, non-invasive, papillary, low-grade Saudi Arabia (Kin& Ahdulaziz Me<jjcal Qly Group) - Papillary urothelial carcinoma, low-grade United Kingdom (John Radcliffe Hospital) - Non-invasive papillary transitional cell carcinoma, grade II Oman (Sultana! of Oman) - Papillary urotholial neoplasm of low malignant potential

ea.~ 9 . Diagnos·is: Urotbc.lial carcinoma in-situ, kidney and ureter

T-73000, M-81203

Case 9 -References: van der Meijden AP, Sylvester R, Oosterlinck W, et al. EAU Guidelines on the Diagnosis and Treatmeut ofUrotbelial Carcinoma

In-Situ. Eur Uro/2005; 48(3):363-371. Broussard JN, Tan PH, Epstein JT, et al, Atypia in lnverted Urothelial Papillomas. Pathology and Prognostic SigniJicaoce. Hum

Patlro/2004; 35(12):1499-1504. Santos L, Amaro T, Costa C, et al. Ki-67 Index Enhances tbe ProgJ>ostic Accuracy of tbc Urotbcliat Superficial .Bladder Carcu~oma

Risk. Group Classificatioa. lntJ Cancer2003; 105(2):267-272. -Swierczynski SL and Epstein 11. Prognostic Significance of Atypical Papillary Urothellal Hypeiplasia. Hum Parlw/2002;

33(5):512-S 17, Montironi R, Lopez-Beltran A, Mazzuccbelli R, et al. Classification and Gradiog of tile Non-Jovasive Urotbelial Neoplasms. Recent

Advances and Controversies. J Clin Patho/2003; 56(2):91-95.

Case No. 10, Accession No. 30680

Alameda (Alameda Oiunty Medical Center) - Urothelial carcinoma, high,grade, invasive Arcadia (ABC Laboratories) - .Poorly differentiated urothclial carcinoma Fontana (Kaiser Permanente\ - Transitional cell carcinoma Hayward/Fremont - Transitional cell carcinoma, bigh-gradc !.a Jolla (Scripps Qinic) - OiUecting duct carcinoma Long Beach (Long Beach veterans Hospital) - High grade transitional cdl carcinoma (7) MQuntain view (El C3mino Hospital) - High grade invasive urothclial carcinoma Oakland - Adenosquamous carcinoma Orange (Qrange County Pathology) - Poorly differentiated carcinoma (transitional cell)

February 2008

Qxuard (St. John's Regional Medical Center) - Transitional cell carcinoma (l ); Higb,-grade papillary transitional cell carcinoma (2)

San Diego (Naval Me<jjca! Cegtec) - Urothelial carcinoma San Diego (RCRMQ • Transitional cell carcinoma, bigh-grade San Francisco (UCSF Fellows) - Urothelial carcinoma San Francisco (San Francisco General.Hospital) - Adrenal cortical carcinoma

16 crrR, february 2008 '']\oiinul~ (Subsctiplion A)

Santa Bar!!a!ll • Higb·grade urotbclial carcinoma Santa Barbara (.Cottage Hospital) · Urothe!ial carcinoma, high-grade Santa Rosa (Santa Rosa Memorial t h <pital) • Transitional cell carcinoma, grade mtlll (1); High-grade invasive

urothclial carcinoma (1); Invasive urothelial carcinoma (i) Sonoma • Urothclial carcinoma, high-gf3de Alabama (Baptist Medical Center) • Urothelial carcinoma, high-grade Alabama. Mt. Olive • Urotbelial carcinoma, ltigh-grade Colorado (McKee Medical Center) • Invasive high -grade urotbelial carcinoma Florida Q'allaha.'iSee Pathology A<sociatcs) · Higb-grade urothe!ial carcinoma Georgia . !)ecatur · High·llf3de invasive urothelial carcinoma Illinois. Bya Ridge · TraiiSitional cell carcinoma, high-gf3de Illinois (Heartland Reaiooal Medical Center) • High-grade invasive urolholial carcinoma Indiana (MacNeal Hospital) • High-grade urothelial carcinoma Indiana (SI-Joseph Hospital) • Invasive urotbclial carcinoma, transitional cell carcinoma, high-gf3dc (!);Collecting

duct =inoma (1) Kansas (CVtocbeck L1horatoa) • Undifferentiated carcinoma, ?squamous (l); Poorly differentiated can:inoma,?

urothelial (1) . Louisiana (Orleans Parish Coroner's Offie<;) • High-grade transitional cell carcinoma Mas.<achygus (Berlg;hire Medical Ccpte!) • Collecting duct carcinoma Mas;;achugtts O'ufls-New England Medical Cen1er) - Transitional cell carcinoma Mao;.,achugtts (liM ASS Memorial Mt<lical Cen1er) - Transitional cell carcinoma, high-grade Michigan (l'athology Seryices of West Michigan) • Transitional cell carcinoma, mtill Minnesota (fairview Ridges Hospital) • Urotbelial carcinoma, high-grade Nebraska (Creighton Uniye~Sity Mt<lical Center) • Urotbclial carcinoma, high-gf3de New Mexjco (Aibuqueroue) · Urothclial can:inoma, high-grade New Mexico (JJnive.sl!y of New MexjcQ) - High-grade urothclial carcinoma New York (E!CMC,) - Adrenal cortical carcinoma New Yo!k (Long Island Jewjsb Mt<lical Centec) • Urothelial carcinoma, high-grade New York (Stonv Brook Unjve(l!ity Medical CeQJer) • Transitional cell carcinoma vs. collocting duct carcinoma Ohio (McO.llough-Hydc Memorial Hospital) · Metastatic urothelial carcinoma Pennsylvania (Conmaugb Memorial Hospital) - Metastatic urothclial carcinoma, high-grade Pennsylvania (Prexel Medical Cenle!) · Transitional cell carcinoma, high-grade Pepgsylvania (Lehigh Valley Ho.<oilal) • Transitional cell carcinoma, high-grade Pennsylvania (Magee Women's Hospila!) · High grade urothclial carcinoma Pennsylyi!Dja (St. Elizabeth Health Cen1er) - Squamous cell carcinoma Tenpe.'h<cc ()'sst Tennessee State Uniyersity) - Renal cell carcinoma Texas. Crystal Beach - Carcinoma urotbelial high·8f3de transitional squamous differentiation Texas. Houston · Transitional ceU carcinoma Texa.<. Lubbock • Metastatic high-grade urolhelial carcinoma Texas (Scott & White Memorial Hosllilill) • High-gradel nvasive urotbelial carcinoma Texas Cfhc Methodist Hospital) · Infiltrating urothclial carcinoma Washington (Seattle VA Medical Cenltr) • High-grade carci.noma, could be urothelial metastatic to adrenal West Virgjnia (.Greenbrier Vallev Mt<ljcal Center,) • Poorly differentiated squamous cell carcinoma Australia (Royal Hobart Hospital) · High-grade urothelial carcinoma Brazil, Sao Paulo • High-grade urothclial carcinoma with lymphatic dissemination Canada !Pasqua Hospital) • Urotbelial carcinoma, high-grade Canada (JJnivcrsity flosoila! Sberhrooke) · Papillary urotbelial carcinoma, high-gf3de Hong Kona (Hong Kona BaR!ist Hospjta!) - Invasive urothelial carcinoma, high-grade Ireland (Kerrv General Hospital) • Carcinoma, ?renal or adrenal Ireland LUuiyersitv Olllcae Hospital.) • High-grade metastatic urotbcUal carcinoma Japan (Asashi General HOAAital) • Urotbelial carcinoma, high-grade Japan (Kyo!o Universitv Hospital) • Urothelial carcinoma, infiltrating Saudi Arnbi!! (King Abdu!azjz Medical City Groyp) • Urotbelial carcinoma, high-grade United Kinadom (John Radcliffe Ho.~Jlilill,) · Transitional cell carcinoma, grade ill Oman (Sultan at of OmaQ) • Carcinoma of collecting ducts of Bellini 's vs. transitional cell carcinoma

c~ 10 . Djagnns'JS:

ClTR, February 2008 "Minutes" (Subscription A) 17

High grade urothelial (transitional) carcinoma, kidney T-71000, M-81203

Case 1 Q - Refcrepccs: Olgac S, M.azumdar M, Dalbagni G, et al. Urothelial Carci.noma of the Renal Pelvis. A Clinicopathologic Study of 130 cases . . 4mJ

Surg Palho/2004; 28(12):1545-1552. Perez-Monticl D, Hcs 0 , Michal M, et al. Micropapill:uy Urothelial Garcinoma of tbe Upper Urinary TracL Clinicopathologic Study

of Five Gases. Am J Surg l'adu>l2006; 126(1):86-92. Parwant AV, Heruwi M, Volmar K, et al .. Urothelial Carcinoma with Rhabdoid Features. Report of 6 Gases. Hum Patho/2006;

37(2):168-172. Holmang Sand Jobanssoo SL. Urolhelial Gareinoma oftbe Upper UrineyTract: Comparison Between the WHO/ISUP 1998

Consensus Classification and WHO 1999 Classificatiori System. Uro/2005; 66(2):274-278.

18 CIT(\, February 2008 "Minutes" (Subscription A)