g2-proj-portfolio_en.pdf

Micro & NanosystemsProject Portfolio

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6th Framework ProgrammeInformation Society Directorate-GeneralDirectorate G Information Society Technologies: Components and SystemsUnit G2 Micro and Nanosystems

Head of UnitAugusto de Albuquerque

Scientific staffFrancisco Ibanez (deputy Head of Unit)Marc BoukercheMarcel HugenAndreas LymberisGordana PopovicThomas ReibeJorge SantosThomas SommerGriet Van CaenegemIsabel Vergara Ogando

Former scientific staff members involved in FP6 activitiesDirk Beernaert (Head of Unit)Alejandro Snchez GruesoLeonello Dori

Administrative and support staffHanne CarnolJoelle DelmeirenSaro Derderian Carine HeyvaertTorben Runge JohansenMairead KenehanAnne MorganSofie VerhoeftRoseline Verhoeven

Former administrative and support staffSonja Lenotte

A great deal of additional information on the European Union is available on the Internet.It can be accessed through the Europa server (http://www.europa.eu).

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Micro & NanosystemsProject Portfolio

S i x t h R e S e a R c h a N d d e v e l o p M e N tF R a M e w o R k p R o g R a M M e 2 0 0 2 2 0 0 6

Foreword

The Information Society and Media Directorate General aims to support the development and use of Information and Communication Technologies (ICTs) for the benefit of all citizens as a way to carry forward the Commissions general policy objectives, in particular the Lisbon strategy and goals. One of the targeted actions to fulfil the proposed objective is to support innovation and competitiveness in Europe through excellence in ICT research and development.

During the implementation of the IST priority of the 6th Framework Programme (2002-2006), we have contributed to promote European excellence in developing the components and systems of next generation Information and Communication Technologies. In particular one of our main objectives is to strengthen Europes leadership and industrial competitiveness in the area of integrated micro/nanosystems and interfaces as a key ingredient of Ambient Intelligence Systems and Assistive Environments.

This report provides information on the portfolio of projects funded under the 6th Framework Programme in the area of Micro and Nanosystems. The projects have successfully covered a complementary set of activities, ranging from technologies and systems development (e.g. MEMS, RF microsystems, plastic and organic micro-nanosystems), to product innovation and new manufacturing processes. The use of micro- nanosystems to support applications, such as health and biomedicine, food chain management, displays and robotics, have also been largely covered by the portfolio of projects.

A total of 79 projects have been funded, representing a budget of about 500 million, of which the European Commission contributes more than 300 million. The projects have brought together researchers and industries from both end users and suppliers from some 500 different organisations representing all member states, associated countries and other countries outside the EU, building a large research community contributing to the European Research Area.

The 7th Framework Programme (2007 2013) largely draws on the work carried out and the results obtained under 6th Framework Programme. Research on higher performance and reliable micro and nanosystems is a key technology challenge of the FP7 ICT work program which will be implemented with the objective to ensure industrial leadership of Europe in the next ten years.

Rosalie ZobelDirectorComponents and Systems

...support the development and use of Information and Communication Technologies (ICTs) for the benefit of all citizens...

Table of

contentsForeword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5

1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86th Framework Programme for Research andTechnological Development (2002-2006) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Micro and Nano systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Organic and Large Area Electronics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Display Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

7th Framework Programme for Research andTechnological Development (2007-2013) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Micro and Nano systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Organic and Large Area Electronics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

Display Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

2. Project Portfolio and Rationale . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12Statistics on all proposals received and retained in the different calls for proposal in which the Unit has been involved . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Statistics on the whole portfolio of projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Statistics on projects by thematic cluster . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18

3. List of Projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

Nano Bio ICT (NBIC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24

Sensor based Systems and Storage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .53

Organic/Large area electronics and Displays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69

Micro/Nanosystems for AmI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

Manufacturing/Process Integration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89

Smart fabrics/Interactive textiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101

Support and Coordination Actions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .105

Micro and Nano systemsThe European Commission started to pay attention to the area of Micro and Nanosystems already during the 4th Framework Programme ESPRIT (1994-1998). In those years the R&D focused on Micro-Electro-Mechan-ical Systems (MEMS), and nowadays the area has grown into Micro and Nanosystems (MNS) and Micro and Na-notechnologies (MNT) which are already able to offer a broad band of solutions. The transition started during the 5th Framework Programme (1998-2002) in which the IST Programme emphasized the industrial applications of these devices and MEMS and MOEMS (Micro-Opto-

Electro-Mechanical Systems) shifted towards the notion of Microsystems. In the 6th Framework Programme the attention has kept in the industrial applications of the systems emphasizing the novel applications and phe-nomena expected from the emerging Nanotechnologies, but not forgetting that most industrial applications are still to be expected in the micro dimension.

The evolution of the research on Microsystems during the last years can be summarized with the following quotes:

From small structures and MEMS devices towards Micro and Nano Systems and Smart Systems Inte-gration.

From single silicon devices towards a multitude of materials and integrated systems.

From single disciplines to a very multidisciplinary activity.

1introduction

1 This period (2002-2006) corresponds to the project launch. The actual run-

ning of FP6 projects will be up to 2010.2 Microsystems and Micro-Nano Technology A decade of European

progress and future outlook. D. Beernaert, F.J. Ibaez, and G. Van Caenegem. MST news, 6/05, 34-37 (2005).

This report shows a summary of the activities of the Micro and Nanosystems Unit during the 6th EU Framework Programme for Research and Technological Development (2002-2006)1. The Unit is one active part of the IST Programme of the General Direction for the Information Society and Media inside the European Commission.

6th Framework Programme for Research and Technological Development (2002-2006)

The mission of the Micro and Nanosystems Unit is to strengthen Europes leadership and industrial competitive-ness by making the European Research Area progress in integrated micro/nanosystems and interfaces as key in-gredients of Ambient Intelligence Systems and Assistive Environments and by moving RTD towards innovation. In order to achieve this, the activities of the Unit are based on three pillars:

Technologies and systems development with the objective of pushing further miniaturisation, integration, va-riety, interfaces and exploring the convergence of bio-nano-ICT competencies;Manufacturing and product innovation aiming at increasing performance, functionality and manufacturability; Use of Micro and Nano systems and technologies to support applications.

From single technology devices driven development towards application driven integration of technolo-gies.

FrOM SMALL StrUctUrES AND MEMS DEvicES tOwArDS MicrO AND NANO SyStEMS AND SMArt SyStEMS iNtEgrAtiON. The research area originally started with MEMS, and it focused later on Micro and Nano systems giving more emphasis to the industrial applications of the devices. The area has progressed towards the achievement of even more miniaturised systems with increased performance and functionality, going from micro and nanosystems us-ing single sensing capabilities to multi-sensing miniatur-ised systems. Currently the research is focused to achieve new functionalities and to include these small systems into different objects to make them smarter.

FrOM SiNgLE SiLicON DEvicES tOwArDS A MULti-tUDE OF MAtEriALS AND iNtEgrAtED SyStEMS.Originally the research on Microsystems was mainly fo-cused on silicon technology. The first devices investigated were, among others, inertial sensor based microsystems, pressure sensors, accelerometers, inkjet printing devices and gyroscopes using surface micromachining or other add-on processes on silicon. Today, several generations of these devices are being industrially exploited. Nowadays, still a lot of research is based on silicon tech-nology. However at the beginning of the 6FP the use of other materials in micro and nanosystems, especially or-ganic materials for low cost flexible and even printable applications, has reached a remarkable interest. Examples of applications using polymer technology are bio-medi-cal sensors, e-paper, smart tags, and smart textiles.

FrOM SiNgLE DiScipLiNES tO A vEry MULtiDiScipLiNAry Activity.A particular feature of micro and nanosystems is their interdisciplinarity. Systems combining sensing, process-ing and actuating are increasingly complex, involving a variety of disciplines and principles from physics, chem-istry, engineering, biology and so on. The systems may also integrate mechanical, electrical and biological func-tions in order to get new features like uninterrupted ac-cess to information, security and ease of use.

FrOM SiNgLE tEchNOLOgy DEvicES DrivEN DEvELOpMENt tOwArDS AppLicAtiON DrivEN iNtEgrAtiON OF tEchNOLOgiES.The integration of different technologies is another char-acteristic of the area. Once the capabilities and feasibility of MEMS devices were demonstrated, the research has been oriented to the development of more industrial ori-ented technologies and to speed up the industrialisation phase of products in order to better capitalise the innova-tion offered by these devices. Severe international com-petition requires rapid product change and shorter time to market. Therefore, a large variety of technologies have to be developed and integrated in order to bring a family of processes into an application driven industrialisation.

Organic and LargeArea ElectronicsSince the early 80sa new class of potentially disruptive electronic technologies based on R&D on organic ma-terials is now emerging and could reach a market size equivalent to that of silicon in 20 years from now. EU companies own key IPR relating to materials and proc-esses. The drivers for this new technology are the devices that can be cost effective even for large area (unlike silicon). Further the whole technology can be made on flexible plastic foils. Today all basic functionalities have been demonstrated, e.g. logic gate integration, efficient light emission, photo-voltaic energy conversion, sensors. Work is being done on thin film polymer batteries. The technology is compatible with printing, currently a strong (traditional) EU industry. This has been demon-strated for most of the necessary process steps individu-ally; however a full system entirely printed does not yet exist. EU companies own key IPR relating to materials and processes. Low investment in-line manufacturing seems feasible unlike for silicon or LCD displays. It offers a unique opportunity for custom device manufacturing close to the system builders, and therefore in the EU for the EU market. This is essential to EU business because EU industries are the best to conceive new designs, and large area devices like flexible displays or lighting are the most visible part taking advantage of it. It should there-fore promote local manufacturing and jobs. Key technology breakthroughs happened in the last year so that the first niche applications will come out within 2 years: e-paper, e-tags, smart packages, smart labels and tags. The concept is potentially expandable to sys-tems in foils, integrating other components like silicon ICs and Micro-Nano systems into flexible substrates. It could stimulate the convergence of traditional intercon-nects with flexible substrates and large area active organ-ic electronics. In FP6 the EC has invested over 100 Mio Euro within the organic and larger area electronics. Only a small por-tion of the projects are supported by the unit Micro and Nanosystems.

Display SystemsQuality of life depends on how well we perceive visual in-formation because vision is our main sensory channel to interact with the surrounding world. The same holds for interfacing with the Information Society through displays and visualisation engines. They can already adapt the in-formation to the needs of the user, changing character font and zooming according to his/her perception needs. In the future high performance 2D displays and intelligent sig-nage will be integrated in our surrounding, adapting our environment to our needs and to our mood. E-books will prevent young children from carrying heavy text books.

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Zero power foldable e-paper technology will be used for large image delivery on small portable devices, and for letters and reports of time-limited interest, saving energy and forestry reserves. Plastic displays are light, flexible and safer than glass in portable devices and cars. Simple plastic electronics and signs printed on packaging will allow full traceability of the goods and visual warning. High resolu-tion e-glasses will provide a lightweight everywhere avail-able high quality visual interface to information and the virtual world, also allowing augmented reality applications like navigation information super-imposed over the natu-ral view of our surrounding.

The use of the 3rd dimension to realise visual representa-tions much closer to reality will be the next media revolu-tion, now about to happen thanks to the convergence of the necessary enabling technologies. Surgeon will review 3D scanners data with 3D displays for simulation before surgery, or for assistance during operation. Professionals will share and interact with realistic 3D models of the ob-jects that they are designing as a team. Immersive 3D movies with near holographic presence will happen next when compatible technologies for real-world image ac-quisition and display will be demonstrated together and standardised.

7th Framework Programme for Research and Technological Development (2007-2013)

Micro and Nano systemsFP7 will keep paying attention to the area of Micro and Nanosystems and smart systems integration. This is still an emerging area with applications in many industrial sectors and it is one of the most important drivers of the Information and Communication Technologies (ICT). It covers all steps needed to form systems out of compo-nents, systems that are able to take information from the environment through sensors, to process it electronically, to communicate it and to close the loop by taking an ap-propriate action.

The main driving lines of the research in this area under the 7FP will be:

Next-generation smart systems3: Major break-throughs in intelligent sensor and actuator systems re-garding complexity, miniaturisation, networking, and autonomy. Micro/nanoscale smart systems with high-er performance at lower cost and lower power con-sumption for specific applications. Energy-manage-ment, scavenging and storing techniques. Design and packaging technologies for new sensors, actuators and macrosystems, their combination and integration. In-novative devices and integrated systems with very high density mass storage capacity building on progress in solid-state semiconductors, micro/nanodevices, me-chanics, optics, electronics and magnetism.

Micro/nano/biotechnologies convergence: Con-verging micro/nano, bio and information technol-ogies for the development and production of in-

tegrated systems for specific applications, such as environmental monitoring, agriculture and food quality management, safety, security, biomedical and lifestyle applications. Innovative bioMEMS, biosensors, lab-on-chip microsystems and autono-mous implants and bio-robots. Research will also address packaging, multilevel interfacing, manu-facturing, as well as ethical and societal issues.

Integration of smart materials: Integration of mi-cro-nano technologies and smart systems into new and traditional materials, e.g. textiles, glass, paper, etc. Major outcomes are the adoption of advanced polymeric, biocompatible, bioconnective, flexible or very durable materials and the integration of such materials with e.g. conductive fibres and materials at the fibre core, microelectronics components, user interfaces, power sources, software, all-in-one fabric, for personal (wearable) or other applications. Issues such as user-friendliness, quality, cost and comfort should be considered.

From smart systems to viable products: Advanced microsystems manufacturing technologies for the whole value chain (design, materials, processes, mi-cro-/nano-scale devices, packaging testing and reli-ability) with a focus on cost-effective sensor/actua-tor and system integration technologies, supported by alternative fabrication and testing processes for short time-to-markets. Pre-industrial validation of new manufacturing concepts suitable for large-scale production will also be addressed.

Smart systems for communication technologies and data management: Integration of smart mi-cro/nanosystems into the network domain with emphasis on the communication hardware required and the management of information emerging from smart devices. This includes solutions for adaptable

3 Smart Systems are able to sense, diagnose, describe and qualify a situation

and to mutually address and identify each other. They are predictive, enable the system to interface, interact and communicate with the environment and with other smart systems.

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RF and HF technologies. Data management, stor-age and processing contributing to the functionality of smart systems will also be addressed.

Support actions will ensure broad access to mi-cro/nanosystems manufacturing technologies, in particular by SMEs, identify training and education needs of the area proposing appropriate measures and establish specific measures aiming at coordina-tion and dissemination of smart systems integration R&D at European level.

Organic and Largearea technologiesResearch activities aim at integrating organic semicon-ductors and light emitting components in a cost effective method into new systems. Especially the focus is on new or cost effective manufacturing technologies with a road-map to all wet printable processes including adaptation of existing semiconductor materials, device characterisa-tion, design rules, clean & flexible substrates and more effective encapsulations, Interconnects and functional foils lamination, lab-on-chip, energy scavenging, power control and storage, processing, sensing, visualisation and interfaces. The heterogeneous integration of organic electronics within standard microsystems will be also addressed by this objective.Attention should be paid to the overall manufacturing aspects including cost, capital investment and environ-mental impact. Support measures will include access to advanced man-ufacturing and design competences, training and edu-

cation for organic and large area electronics, joint user assessment of prototype equipment from European sup-pliers and will develop synergies between the electronics and the printing sectors on circuit design, manufacturing equipment and standardisation.The funding will be mainly allocated to Streps, but mini-mum 2 IPs, 1 NoE and 4-5 CSA should be funded.

Display SystemsNew technologies for high performance visualisation sys-tems taking perceptual and usability issues into account. Research will address innovative enabling components like microdisplays/imaging valves, intelligent light sources, image processing and sensor feedback, for extended col-our gamut, high contrast and resolution, and new means of user interaction. Further outcome will be for portable display systems (e.g. zero-power and ruggedized displays, flexible/transparent devices, energy efficient micro-pro-jectors, and lightweight high-performance wearables) and new design opportunities. 3D content capture, information processing and display to multiple users with unrestrained viewing is an important emerging topic for both profes-sional and consumer applications.

Activities in immersive visualisation systems and ergo-nomic multi-viewer 3D imaging will:

Contribute to strengthen Europes scientific and business position in these areas and lead to break-through and innovative solutions for professional and consumer markets.

Enable the use of the third physical dimension for professional applications, movies, games and TV.

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The Micro and Nanosystems unit has been involved in the following FP6 Calls: iSt cALL 1 (DEcEMbEr 2002):

Objective: To improve the cost-efficiency, perform-ance and functionality of micro and nano-systems and to increase the level of integration and minia-turisation allowing for improved interfacing with their surrounding and with networked services and systems. This should foster their integration into a wide range of intelligent products and applications.Focus on: to stimulate applied multi-disciplinary research in the area of networked microsystems and the underlying micro and nano-technologies for miniaturisation and integration of microsystems into networked intelligent products as well as to im-prove their interfacing with their surrounding.Coverage after evaluation: The objectives were well covered. A particular important issue is that all IP and NoE have or intend to build links with national projects, also links with EUREKA initiatives ME-DEA (on RF), EURIMUS (on Microsystems) and PIDEA (packaging). This allows to better link Eu-ropean initiatives with initiatives at national level building thus realising ERA in this area.

iSt cALL 2 (JUNE 2003)Objective: To develop, demonstrate and prepare for industrialisation emerging display technologies re-lated to organic materials, lightweight near-to-the-

eye information terminals and large size displays for the consumer like wall paper TV displays in order to improve their performance, cost efficiency, their integration in any system and their interfacing with the user.Focus on: Mastering stable and light efficient or-ganic display technologies, and advancing organic electronics; developing display solutions for small form factor high information content communica-tors and achieving their integration and demonstra-tion in complete systems; overcoming todays 3D multi-viewer dynamic visualisation complexity and limitations. Coverage after evaluation: The proposals selected covered all topics of the call in varying width and depth with emphasis on organic display technolo-gies including their manufacturing processes. This was considered a significant extra contribution on top of ongoing and planned activities. The topic of 3D displays was partially covered. A coordination action involving most of the European community in display technologies was also selected.

iSt cALL 3 (JUNE 2004)Objective: This call was only open for Coordination Actions and Specific Support Actions in collabora-tion with other Units and Directions.Focus on: To stimulate, encourage and facilitate the participation of organisations from the New Mem-ber States (NMS) and the Associated Candidate Countries (ACC) in the activities of IST; to prepare

2project portfolio and RationaleThis section shows statistic data describing the portfolio of projects of the Micro and Nanosystems Unit funded under the FP6 Programme. As a summary a total of 79 projects have been funded representing a budget of about 500 millions from which the European Commission contributes with about 300 millions. The projects have brought together researchers, industries and end users from some 500 different organisations coming from 35 countries, building a large research com-munity and contributing therefore to the European Research Area.

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for future international co-operation in IST; and to progress towards the achievement of the objectives of a European Research Area in a given IST fieldCoverage after evaluation: All topics were covered by the selected proposals. From the selected propos-als only one CA and one SSA are being followed by Micro and Nanosystems Unit.

iSt NMp SEcOND JOiNt cALL (JUNE 2004)Objective: RTD proposals on selected topics with integration on IST and NMP priorty areas.Focus on: Bio-sensors for Diagnosis and HealthcareCoverage after evaluation: The selected propos-als addressed well the call text and combined IST and NMP aspects on biosensor research, system integration and application development in a really integrated manner. Some proposals address compa-rable application objectives, using however compet-ing technological approaches or solutions and vice versa. In case of comparable (even if not identical) technological solutions, these are targeting different applications e.g. biosensors to be used for the diag-nosis of different types of cancer or the use of lab-on-a-chip for different point of care applications.

iSt cALL 4 (DEcEMbEr 2004)Objective: To push the limits of integrated micro/nano systems through research on a family of mixed technologies (combining for instance micro-nano-technology, ICT and biotechnology) and integration technologies for very high density or for integrat-ing micro/nano devices in various materials and into large surfaces. Validation and demonstration of maturing silicon-based and polymer-based tech-nologies, manufacturing and design issues are also targeted.Focus on: Heterogeneous technologies and devices for mixed-technology micro/nano systems (eg mi-crofluidic/ICT/micro-nano, bio/ICT/micro-nano, chemical/ICT/micro-nano combined); technology for very high density hybrid integration (towards e-grains, e-dust); integrating micro/nano devices in various materials and in or on large surfaces; Manu-facturing and design of mixed technology-based micro/nano system; Validation and demonstration of networked micro/nano systems and their use to address problems and opportunities in a holis-tic manner combining device, system, information management and application competencies; road-maps, specific coordination and support activities to prepare for a research agenda and to build the research community in order to define major trends and to address the ICT-bio-micro-nano-technology combined field, Coverage after evaluation: The ranked proposals showed a good coverage of most of the workpro-gramme with the exception of the topic on valida-tion and demonstration of networked micro/nano-systems, in which only a few proposals were received

and none of sufficient quality to be retained. As a consequence, this topic was also open in call 5.

iSt cALL 5 (MAy 2005)Objective: To validate integrated micro/nano sys-tems technology for new products and services in key application fields such as miniaturised au-tonomous robotic systems, mass storage systems and visualisation systems. Micro/nano-based inte-grated medical systems are also targeted to explore the many opportunities offered by combining bio-, nano- and information-related technologies.Focus on: Integrated systems and tools for point-of-care diagnosis, monitoring, and drug delivery; autonomous and miniaturised (micro-) robotic systems; innovative mass storage systems; novel 3D visualisation systems; very large area displays and highly-integrated display solutions; validation and demonstration of micro/nano systems-enabled tools and subsystems; roadmaps, specific coordina-tion and support activities to prepare for a research agenda and to build the research community in or-der to define major trends and to address the ICT-bio-micro-nano-technology combined field.Coverage after evaluation: All major areas of the work programme were covered however the distri-bution between the areas was uneven, with a higher contribution of biomedical proposals.

iSt cALL 6 (DEcEMbEr 2005)Objective: The aim is to extend the time during which elderly people can live independently in their preferred environment with the support of ICTs. It therefore targets the needs of the individual elderly person, their families and caretakers, rather than the health care institutions. This includes for ex-ample assistance to carry out daily activities, health and activity monitoring and enhancing safety and security. It also covers means to improve access to social, medical and emergency services, and to fa-cilitate social contacts as well as access to context-based infotainment and entertainment. This call was organised as a joint effort of different Units in DG INFSO. Focus on: Research will aim at highly innovative ICT-based solutions that are cost effective, reliable and user friendly for assisted living taking into ac-count design-for-all principles where applicable. It will lead to integrated environments bringing to-gether progress in various ICT building blocks and responding to key user requirements.Coverage after evaluation: The two main foci of the call, namely the integration of advanced ICTs into working prototypes for assisted living and the development of AAL systems reference architec-ture, were well addressed by the retained portfolio of proposals. From the selected proposals only one IP and one STREP are being followed by Micro and Nanosystems Unit.

1

Statistics on all proposals received and retained in the different calls for proposal in which the Unit has been involved

The table below gives information on proposals received and retained projects for each call in which the Micro and Nanosystems Unit has been involved.

Date

IST-Call 1 IST-Call 2 IST-Call 3 NMP-ISTJoint call IST-Call 4 IST-Call 5 IST-Call 6 TOTAL

Dec2005

May2005

Dec2004

June2004

June2004

June2003

Dec2002

Proposals submitted

Retained proposals

EC Contribution of retained proposals (M)

30110.31066.583.116.991.6825.298.0

792 (13)718238 (25)62 (43)5719

251422184741112701776

4Total proposals submitted for IST Call 1, 2, 4 and 5.

5IST Call 3: From the 43 proposals retained, 2 are followed by the Micro and Nanosystems Unit.

6NMP-IST Joint call: From the 25 proposals retained, 8 are followed by the Micro and Nanosystems Unit.

7IST Call 6: From the 13 proposals retained, 2 are followed by the Micro and Nanosystems Unit.

8IST Call 3: EC contribution of the 2 proposals followed by the Micro and Nanosystems Unit.

9NMP-IST Joint call: EC contribution of the 8 proposals followed by the Micro and Nanosystems Unit.

10IST Call 6: EC contribution of the 2 proposals followed by the Micro and Nanosystems Unit.

The following tables provide information on the type of instrument, only for the calls for proposals in which only the Unit of Micro and Nanosystems was involved.(CA: Coordination Action; IP: Integrated Project; NoE: Network of Excellence; SSA: Specific Support Action; STRP: Specific Targeted Research Project)

IST-Call 1 TOTAL

Proposals submitted

Retained proposals


76

19

CA IP NoE SSA

3

STRP

35

6

14.1

1

0.8

14

4

20.8

22

6

61.2

2

2

1.03 98.0

IST-Call 2 TOTAL

Proposals submitted

Retained proposals


17

7

CA IP NoE SSA

1

STRP

12

5

9.9

0

0

0

0

0

2

1

14.3

2

1

1.0 25.2

1

TOTALCA IP NoE SSA STRP

IST-Call 4 TOTAL

Proposals submitted

Retained proposals


74

23

CA IP NoE SSA

2

STRP

54

14

35.3

1

0.3

0

0

0

15

7

47.0

3

1

0.5 83.1

IST-Call 5 TOTAL

Proposals submitted

Retained proposals


84

18

CA IP NoE SSA

6

STRP

56

9

22.3

3

1.1

0

0

0

19

6

43.1

3

0

0 66.5

Statistics on the whole portfolio of projects

The following table gives information for the complete portfolio of projects:

Total number of Projects 5 21 4 6 7943

Total Project Costs (M)

3.4

Average Duration (months)

Average number of participants 7.4 16.1 20.5 6.2 10.57.7

24 42.6 45 31 36.835.5

173.3 20.8 2.9 301100.6Total Project EC contribution (M)

3.4 312.3 22.8 2.9 507.2165.8

Total number of participants 37 339 82 37 828333

Distribution of total number of

projects by type of project

STRP54%

NoE5%CA

6%

SSA8%

IP27%

Distribution of total EC

contribution by type of project

IP58%

STRP33%

NoE7%

SSA1%

CA1%

1

4

2

0

6

8

10

12

14

16

Germ

any

Unite

d Kin

gdom

Fran

ce

Belg

ium

Italy

Neth

erlan

ds

Spain

Gree

ce

Switz

erlan

d

Finlan

d

Israe

l

Hung

ary

Irelan

d

Norw

ay

Swed

en

Rom

ania

Coordinating organisations by country

Germ

any

Fran

ceUn

ited K

ingd

om Italy

Belg

ium

Neth

erlan

dsSw

itzer

land

Spain

Finlan

dSw

eden

Gree

ceIre

land

Austr

iaIsr

ael

Denm

ark

Norw

ayHu

ngar

yPo

land

Slova

kiaCz

ech

Repu

blic

Rom

ania

Portu

gal

Liech

tens

tein

Russ

ian Fe

dera

tion

Lithu

ania

Turk

eyKo

rea

Latv

iaM

alta

Chin

aAu

strali

aBu

lgar

iaSlo

veni

aEs

toni

a

70

60

50

40

30

20

10

0

Distribution of total EC contribution by country.

EC contribution per country (Millions of Euro)

HE26%

IND35%

OTH8%

RES31%

Distribution of total EC contribution

by type of activity

RES: Research organisations.

HE: Organisations only or mainly established for

higher education or training.

IND: Industrial organisations private or public.

OTH: Organisations not fitting in one of the

above categories

1

SME participation

IP

NoE

STP

CA

IST-Call 3

SSA

Total Instrument

Rec. Funding (K)

-

SME Participation

N. Participants Rec. Funding (K) N. Participants

-

-

850

732

-

-

-

12

18

-

-

-

262

78

-

-

-

31%

11%

-

-

-

1

3

-

-

-

8%

17%

IP

NoE

STP

CA

IST-Call 4

SSA

Total Instrument

Rec. Funding (K)

46 994

SME Participation


-

35 350

493

235

99

-

106

8

4

6 149

-

6 897

103

126

13%

-

20%

21%

54%

23

-

28

2

1

23%

-

26%

25%

25%

IP

NoE

STP

CA

IST-Call 2

SSA

Total Instrument

Rec. Funding (K)

14 320

SME Participation


-

9 680

1 000

-

22

-

43

4

-

1 621

-

3 240

79

-

11%

-

33%

8%

-

3

-

12

1

-

14%

-

28%

3%

-

IP

NoE

STP

CA

IST-Call 1

SSA

Total Instrument

Rec. Funding (K)

61 200

SME Participation


22 340

14 500

1 030

820

154

89

45

16

1

14 522

773

4 753

516

820

24%

3%

33%

50%

100%

40

4

16

8

1

26%

4%

36%

50%

100%

IP

NoE

STP

CA

IST-NMP 2Joint Call

SSA

Total Instrument

Rec. Funding (K)

-

SME Participation


-

16 896

-

-

-

-

61

-

-

-

-

3 691

-

-

-

-

22%

-

-

-

-

15

-

-

-

-

25%

-

-

1

IP

NoE

STP

CA

79

IST-Call 5

SSA

Total Instrument

Rec. Funding (K)

43 200

SME Participation


-

22 480

-

1 090

79

-

67

-

13

10 681

-

2 675

-

195

25%

-

12%

-

18%

28

-

11

-

2

35%

-

16%

-

15%

IP

NoE

STP

CA

79

IST-Call 6

SSA

Total Instrument

Rec. Funding (K)

8 250

SME Participation


-

2 000

-

-

13

-

8

-

-

2 433

-

228

-

-

29%

-

11%

-

-

4

-

1

-

-

31%

-

12%

-

-

IP

NoE

STP

CA

TOTAL

SSA

Total Instrument

Rec. Funding (K)

173

SME Participation


22

100

3

3

367

89

330

40

36

35

1

21

1

1.4

20%

4%

21%

28%

48%

98

4

83

12

7

27%

4%

25%

30%

22%

TOTAL 301 841 59.4 20% 204 24%

Statistics on projects by thematic cluster

The projects have been classified in seven groups accor-ding to the activities of the Micro and Nano systems unit. The groups are as follow:

Micro Nano Bio Convergence systems Sensor Based Systems and StorageOrganic/Large Area Electronics and Display Sys-temsMicro and Nano systems for Ambient Intelligence (AmI)Manufacturing and Process integrationSmart fabrics and interactive textilesSupport and coordination actions

MicrO NANO biO cONvErgENcE SyStEMSThis group is made by projects dealing with the conver-gence of nano, bio, and information technologies with

a wide range of applications from health care to food quality monitoring. The main areas covered by the pro-jects are: Biosensors systems for screening and diagnosis, medical implants including implantable biosensors, drug delivery and systems for imaging and delivery. This is the biggest group of projects in terms of number of projects and budget, representing one third of the total budget.

SENSOr bASED SyStEMS AND StOrAgEThis group includes a number of projects in which sensing is an important part of their activities, excluding those projects dealing with biosensing which were already in-cluded in the previous group. The main topics covered by this group of projects are: small 3D cubes, MEMS based oscillators, MEMS for RF and millimetre wave commu-nications, fully autonomous helicopter, position sensor based on magnetoresistive nano-contacts, olfaction sen-

1

sors, sensors for automatic handling of nano-objects, and vibration energy scavenging. Projects on mass storage are also included in this group. These projects deal with innovative mass storage systems building upon progress in micro-nano-devices, mecha-nics, optics, electronics, and magnetic know how.

OrgANic/LArgE ArEA ELEctrONicS ANDDiSpLAy SyStEMSThis group includes projects dealing with electronic tech-nologies based on R&D on organic materials which can be cost effective even for large areas. Projects on Display systems which often make use of emerging technolo-gies related to organic materials are also included in this group. The objectives of this group of projects are mainly: the applications of polymer electronics and the develop-ment of the underlying technologies; research on novel materials, devices, handling and production methods for flexible displays; Roll-to-roll manufacturing technology for flexible OLED devices and arbitrary size and shape displays; Contact printing of electronics and opto-elec-tronics; and Smart High-Integration Flex technologies. Projects in the display subgroup focus on the industriali-zation emerging displays technologies related to organic materials, lightweight microdisplays, large size displays, and 3D displays.

MicrO AND NANO SyStEMS FOr AMbiENt iNtELLigENcE (AMi)The projects included in this group have a general view on the use of micro and nano systems for ambient intel-ligence. All projects put emphasis on user-friendliness, efficient and distributed services support, user empower-ment, and support for human interactions. This vision as-sumes a shift away from PCs to a variety of devices which are unobtrusively embedded in our environment and which are accessed via intelligent interfaces. Examples of the topics covered by these projects are microsystems platform for context-aware mobile services and appli-

cations, and networked multisensor system for elderly people covering health care, safety and security in home environments.

MANUFActUriNg AND prOcESS iNtEgrAtiONThis group of projects deals with microsystems manu-facturing technologies for the whole value chain, from design to packaging testing and reliability. Examples of topics are packaging, lithography technologies, high den-sity integration, and batch integration. There are also a number of service actions projects supporting academic research, feasibility research, pro-totyping, training and education in the manufacturing sector.

SMArt FAbricS AND iNtErActivE tExtiLES Projects inside this group form, together with three others, the cluster of EC co-financed projects on smart fabrics and interactive textiles (SFIT cluster of projects - http://www.csem.ch/sfit/ ). The topics covered by these projects are the integration of advanced fibres and materials at the fibre core, microelectronics components, user interfaces (e.g. sensors, displays, speakers), power sources and embedded software. SFIT & Flexible Wearable Systems should fulfil user needs and expectations in terms of user-friendliness/functionality, cost, fabric resistance, comfort, robustness and reliable and accurate performance. The cluster will be expanded with FP7 projects and seeks collaboration with other Commission services and pro-jects active in related SFIT fields.

SUppOrt AND cOOrDiNAtiON ActiONSThis group includes all Specific Support Actions and Coordination Actions type of projects. Examples of the topics covered by this group of projects are European network pursuing the integration of New Member States and Accession Countries in ERA or roadmaps in various areas such as displays, RF micro-nano-systems or micro- nano-biotechnologies applications.

The following tables provided a breakdown by thematic clusters.

Nano Bio ICT (NBIC)

Organic/Large area electronics and Displays

Micro- Nanosyst. for AmI

Number of funded projects

Manufacturing / Proce. Integ.

5

5

21

0

4

0

6

6

CA IP

0 0

0

0

0

0

0

SSA

2

18

9

7

1

6

2

STRP

0

1

1

0

NoE

6

3

4

3

3

2

0

0

0

0

0

0

43

0

Smart fabrics, Interactive textiles

Support and Coordination

TOTAL

TOTAL

Sensor based Systems and Storage

24

14

11

5

10

4

11

79

20

Distribution of budget by thematic cluster

Nano Bio ICT (NBIC)



Micro/Nanosystems for AmI

Manufacturing/processes integration

Smart fabrics/Interactive textiles

Support and Coordination Actions

35%

18%18%

11%

10%6% 2%

Nano Bio ICT (NBIC)


Micro- Nanosyst. for AmI

Distribution of budget per area

Manufacturing / Proce. Integ.

301

6

101

55

54

35

31

19

EC contribution (Millions )

Smart fabrics, Interactive textiles

Support and Coordination

TOTAL


21

3list of projectsNano Bio ICT (NBIC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24

Sensor based Systems and Storage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .53

Organic/Large area electronics and Displays. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69

Micro/Nanosystems for AmI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

Manufacturing/Process Integration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89

Smart fabrics/Interactive textiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101

Support and Coordination Actions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .105

22

Project acronym Type of instrument

BIOGNOSIS

COCHISE

DVT-IMP

GOODFOOD

HEALTHY AIMS

IMANE

INDIGO

INTELLIDRUG

LOCCANDIA

MASCOT

MICRO2DNA

MOT-TEST

NANOSPAD

NEMOSLAB

NEUROPROBES

OPTOLABCARD

P.CEZANNE

S.I.G.H.T.

SABIO

SEMOFS

SENSATION

SMART-BIOMEMS

TOXICHIP

VECTOR

STREP

STREP

STREP

IP

IP

STREP

STREP

STREP

STREP

STREP

STREP

STREP

STREP

STREP

IP

STREP

IP

STREP

STREP

STREP

IP

STREP

STREP

IP

Sensor basedSystems and Storage



CONTACT

FLEXIDIS

POLYAPPLY

ROLLED

SHIFT

FORK

HOLOVISION

IMPROVE

MUTED

NANOPAGE

OSIRIS

STREP

IP

IP

STREP

IP

STREP

STREP

STREP

STREP

STREP

IP


3DTUNE

AMICOM

e-CUBES

GOSPEL

MUFLY

MUNDIS

NANOHAND

NANORF

NANOTIMER

VIBES

DYNAMAX

STREP

NoE

IP

NoE

STREP

STREP

IP

STREP

STREP

STREP

STREP


EMMA

PARMA

PROTEM

STREP

STREP

IP

Micro/Nanosystemsfor AmI


MIMOSA

MINAMI

NETCARITY

PLASMO-NANO

SENSACTION-ALL

IP

IP

IP

NoE

STREP

Nano Bio ICT (NBIC)

Manufacturing/Process Integration


DAVID

DELILA

HIDING DIES

STREP

STREP

STREP

23

Support and coordination


ADRIA

ARCORC

ARRRO

BRIDGE

ENCAST

ENCASIT

ERA PILOT MINA TSI

MINOS - EURONET

NANOWAYS

NEXUSPLUS

WIND

CA

SSA

SSA

CA

CA

CA

CA

SSA

SSA

SSA

SSA


INOS

INTEGRAMPLUS

MICROBUILDER

PATENT-DFMM

PROMENADE

Q2M

RF-PLATFORM

STREP

IP

IP

NoE

STREP

STREP

IP


BIOTEX

CONTEXT

PROETEX

STELLA

STREP

STREP

IP

IP

Smart fabrics/Interactive textiles

2

viSiON & AiMThe main objective of this project is to develop a unique integrated DNA and protein detection system of an easy-of-use and cost-effective nature for medical diagnostics. The system targets at a fast as well as reliable DNA and protein testing. Aiming for point of care and doctors of-fice applications, e.g. early cancer recognition, this new testing system will improve public health. Moreover the project will enable a broad range of future applications in genomic risk analysis, individualized therapy and antibody detection for identification of diseases, resist-ances and allergies. Today bio-molecular detection is a promising technology for medical diagnosis with a high socioeconomic impact. However, due to its complexity and costs, todays systems are restricted for the use at specialized laboratories, making testing expensive and time-consuming. This project aims to overcome these problems by providing a detection system based on di-rect electrical read-out, which can improve robustness

and substantially decrease costs. This multianalyte de-tection system includes novel integrated sensor dispos-ables consisting of the sensor array, the on-chip CMOS read-out circuit, the biochemical sensor interfaces as well as suitable assays. By detection of mass changes at their surface, sensors work label-free according to key-lock principles. Recent progress in DNA and pro-tein cancer marker testing will form the basis for the development of assays for the new system. An easy-to-use read-out setup will be developed, meeting require-ments of robustness and usability. A clinical validation of the system in early diagnosis of cancer is envisaged to demonstrate the enormous impact of this key technol-ogy for public health. The project will facilitate the entry of sensor array systems into the enormous in-vitro test market. It lays the foundation for strong scientific and economic collaboration between European companies and institutes which will last long beyond the conclu-sion of the project.

BIOGNOSISIntegrated Biosensor System for Label-Free In-Vitro DNAand Protein Diagnostics in Health-Care Applications

Project Number 016467

Contact

Wolfgang Rossner

SIEMENS AKTIENGESELLSCHAFT

Corporate Technology MM2

Otto-Hahn-Ring 6

81730 MUENCHEN

GERMANY

e-mail: [email protected]

Web site

http://www.biognosis-info.de

Timeline

Start: 1 August 2005

End: 1 July 2008

Budget

Overall Cost: 6.120.000

EC Funding: 3.800.000

Project Partners

SIEMENS AKTIENGESELLSCHAFT

Corporate Technology MM2 D

BIOSENSOR APPLICATIONS SWEDEN AB S

VTT Technical Research Centre of Finland FIN

CRANFIELD UNIVERSITY UK

Medizinische Universitt Innsbruck A

UPPSALA UNIVERSITET S

PERLOS OYJ - FIN

Nano Bio ict

STR

EP

2

viSiON & AiMCOCHISE is the first step of an activity aimed at the development of enabling micro-technologies to moni-tor physiological cellular interactions at the ingle cell level with a high throughput. It will be applied first to the immunological monitoring of anti-tumor vaccina-tions, singling out the rare effector cells (in the order of 10-3) that are actually active against tumor cells. The sensor that we are developing consists of an orderly matrix of about 4,000 living cells deposited in micro-wells created in a biocompatible substrate that also serves as a high-density circuit board. The microwells are monitored by an external microscope and have an embedded addressable impedance sensor. The key point is that each microwell can force contact between indi-vidual cells, and detect consequences of these contacts. The project integrates on the same platform several

technologies such as electronic sensing, microfluidic interfaces for cell dispensing, control of osmotic bal-ance of nutrients, management of evaporation, surface nano-modifications for management of fluid flows (e.g. hydrophilic and/or hydrophobic surface tend to drive or repel droplets) and avoidance or induction of surface cell adhesion. At the system level, cell delivery will lev-erage recent results that allow to delivery single cells in an effective way. An important side of the research is the definition of new therapeutic and diagnostic protocols for the immunotherapy of cancer. As a first step, we will apply our technology to the analysis of anti-tumor lytic effector cells, for a precise quantification of how many lytic events happen in the array, their locations and tim-ings. A major advantage is that the cells are kept alive and can be retrieved individually for further analysis, such as gene expression profiling.

COCHISECell-On-CHIp bioSEnsor for detection of cell-to-cell interactions


Contact

ROBERTO GUERRIERI

ALMA MATER STUDIORUM - UNIVERSITY OF BOLOGNA

VIA ZAMBONI 33

40126 BOLOGNA

ITALY


Timeline

Start: 1 June 2006

End: 31 May 2009

Budget



Project Partners

ALMA MATER STUDIORUM - UNIVERSITY OF BOLOGNA I

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN

FORSCHUNG E.V. D

MICRONIT MICROFLUIDICS BV NL

UNIVERSITY OF FERRARA I

Universite Catholique de Louvain B

AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. S.p.A. I

COMMISSARIAT A LENERGIE ATOMIQUE F

Mindseeds Laboratories S.r.l. - I

STR

EP

2

viSiON & AiMDeep Vein Thrombosis (DVT) and Pulmonary Embo-lism (PE) are major causes of unexpected mortality in hospitals throughout Europe. D-dimer is a recognised biomarker for the diagnosis of a thrombus and is rou-tinely examined in hospital laboratories using a tradi-tional ELISA technique. The clinical need for a fast pre-dictive test for D-dimer has prompted the development of test kits, some of which are deployed at the point-of-care as a means of guiding clinicians. Current D-dimer point-of-care diagnostic kits do not provide accurate, quantitative analysis creating uncertainty amongst cli-nicians who are unable to exclude DVT/PE as a result, and consequently unnecessarily refer many patients for high-cost Doppler ultrasound imaging, creating pres-sure on healthcare services across Europe. The consor-tium, industrially driven by a leading healthcare supplies provider, incorporating skilled SMEs in electro-analysis instrumentation and bio-engineering and including aca-

demic bases in clinical pharmacology, microelectronics, analytical electrochemistry and micro-fabrication aims to integrate four key technologies areas: Bio-engineered antibodies for high specificity immunoassay diagnostics Nano/micro engineered impedimetric analysis electrodes incorporating bio-compatible conducting polymer sub-strates for enhanced detection capabilities Development and packaging of a disposable, sterile, microfluidic mani-fold enabling diagnostics at the point-of-care Developing e-Health diagnostic software toolkit for high positive and negative predictivity D-dimer tests DVT-IMP will inno-vation bio-nano/micro-informatic technologies that will enable the development of a point-of-care device with advanced diagnostic capabilities, including the output of quantitative D-dimer levels, thus increasing confidence and certainty for clinicians, enabling them to confirm or exclude the risk of DVT/PE using the high negative and positive predictive capabilities of the DVT-IMP proto-type.

DVT-IMPDeep Vein Thrombosis - Impedimetric Microanalysis System


Contact

Zulfiqur Ali

University of Teesside

School of Science & Technology, Borough Road

TS1 3BA Middlesbrough

UNITED KINGDOM


Timeline

Start: 1 September 2006

End: 31 August 2009

Budget



Project Partners

University of Teesside - UK

Universit Claude Bernard de Lyon 1 F

Comenius University Bratislava SK

Helena Biosciences Europe UK

Parc Cientific de Barcelona E

Fraunhofer Gesellschaft zur Frderung der angewandten

Forschung e.V. D

Budapest University of Technology and Economics HU

Universit Paris-Sud F

Haptogen Ltd UK

Cenamps UK

STR

EP

2

viSiON The GoodFood project is a Integrated Project presented within the IST thematic area of EC VIFP and aims at de-veloping the new generation of analytical methods based on Micro and Nanotechnology (MST and M&NT) solu-tions for the safety and quality assurance along the food chain in the agrofood industry. Current and future con-cerns related to agrofood safety and quality will increas-ingly require a multidisciplinary and universal approach based on the massive use of simple detection systems able to be used near to the foodstuff. The technology used nowadays to assess food safety and quality relies on lab solutions that are bulky, costly, punctual and time consuming. On the contrary, GoodFood approach will comply, through the development of innovative M&NT solutions, with the needs of ubiquity, low cost and low power, fast response, simple use and fully interconnec-tion to the decisional bodies. A multidisciplinary in-tegration of know-how and technology is required for addressing the broad requirements of the agrofood field. An Integrated Project is proposed to keep such a global view. The Project aims at the vertical integration of Mi-cro and Nano Technologies from the land to the mar-ket. The main demands identified by the agrofood sector will be the applications that will drive the technological developments within GoodFood. The need for increas-ing the control of products at different critical steps of the food chain (control of raw materials, improvement of food processing, monitoring of storage and logistics, and control of safety and quality of final products) will be addressed by GoodFood with a vertical and horizon-

tal integration of food, bio, and electronics experience for developing a set of systems with clear breakthrough solutions to specific safety and quality and traceability requirements. The proposed solutions will be also inte-grated under an Ambient Intelligence approach, which will allow fully interconnection and communication of multisensing systems. The technological developments within GoodFood are driven by the main demands iden-tified by the agrofood sector, and they are focused into a number of relevant food targets. The M&NT inspired solutions developed therein are foreseen as the stepping-stones of the long term GoodFood vision: bringing the lab to the food stuff from the land to the market.

AiMOverall GoodFood objectives are: (a) to demonstrate to the agrofood sector actors (final consumers included) the advantages driven to the complete food chain control by the use of Micro and Nanotechnology inspired systems, (b) to develop and integrate such systems with improved performances compared to the state of the art, and (c) to introduce the Ambient Intelligence (AmI) paradigm in the agrofood chain by developing a vineyard pilot site and by applying the results to the activities of all qual-ity and safety technical solutions of the project. Within this framework, GoodFood aims at developing the new generation of analytical methods based on Micro and Nanotechnology (MST and M&NT) solutions for the safety and quality assurance along the food chain in the agrofood industry. Current and future concerns related to agrofood safety and quality will increasingly require

GOODFOODFood Safety and Quality Monitoring with Microsystems


Contact

Carles Cane

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

C/ SERRANO 117

28006 MADRID

SPAIN


Web site

http://www.goodfood-project.org

Timeline

Start: 1 January 2004

End: 30 June 2007

Budget



Project Partners

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS E

ISTITUTO TRENTINO DI CULTURA I

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN

FORSCHUNG E.V. D

UNIVERSITAT POLITECNICA DE CATALUNYA E

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH

UNIVERSIDAD DE VALLADOLID E

LINKOEPINGS UNIVERSITET S

FUNDACION TEKNIKER E

EADS DEUTSCHLAND GMBH D

CONSIGLIO NAZIONALE DELLE RICERCHE I

COMMISSARIAT A LENERGIE ATOMIQUE - F

CSEM CENTRE SUISSE DELECTRONIQUE ET DE MICROTECHNIQUE SA

- RECHERCHE ET

DEVELOPPEMENT CH

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO

SANTANNA I

CRANFIELD UNIVERSITY UK

IP

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a multidisciplinary and universal approach based on the massive use of simple detection systems able to be used near to the foodstuff. The technology used nowadays to assess food safety and quality relies in lab solutions that are bulky, costly, punctual and time consuming. On the contrary, GoodFood approach will comply with the needs of ubiquity, fast response, low cost, simple use and fully interconnection to the decisional bodies. Long term GoodFood vision is to bring the lab to the foodstuff from the land to the market.

StrUctUrEGoodFood aims at increasing awareness at different lev-els:

To the citizens: To show that Ambient Intelligence (AmI) and ubiquitous sensing can help on increas-ing food safety and quality.

To the Agrofood Community: To demonstrate ad-vantages of the MST, AmI and wireless solutions for new and/or current analytical tools and test methodologies, as well as their impact on improved farming.To the Microsystems industrial community: To show that Agrofood is a good niche market for MST solutions.

To the SME and foundries: To develop demonstrators and market plans that show viability and lower the risks of future market access - To the MST scientific community: To give a path for take-ups, start-ups. A multidisciplinary integration of know-how and technology is required for addressing the broad requirements of the agrofood field. A suitable scenario was identified by the agrofood com-munity for keeping such a global view.

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viSiON This Framework 6 project is developing key microsystem technologies and communication methods that bring in-telligence directly to the human, in the form of medical im-plants and ambulatory measurement systems. Information from these devices will be transmitted out into the wider environment for remote interpretation and diagnosis. Medical applications have been chosen that will have a di-rect positive impact on the health of EU citizens and also contribute significantly to economic growth and intellec-tual capability. In particular, this multi-disciplinary project will integrate and extend the existing State of the Art in microsystems, biomaterials, wireless communications, power sources and body area networks (BANs).

AiMThe overall objective is to produce intelligent medical de-vices that have communication capability and exploit the full range of advanced technologies in design, materials, processes and manufacturing.

The medical products being developed include: Cochlear implant Retina implant and glaucoma sensor Functional electrical stimulation for upper limbs (FES) Sphincter sensor for oesophageal and urological appli-cations Implantable pressure sensor to monitor intracranial pressure Inertial Measurement Unit (IMU) for human body mo-tion and to trigger the FES

In order to achieve this a number of key technologies are being developed including: A body area network enabling communication from implants or on the body devices to a base unit which may be up to 3m away Micro-electrodes Micro assembly techniques, particularly for 3D struc-tures Implantable power sources Biomaterials, suitable for interfacing devices in and on the body

StrUctUrEThe 4 year, 24 partner, project started on December 1st 2003 and already there have been key deliverables in the form of device specifications, communication architectures and some early hardware demonstrators. Many of these have been presented at various meetings and in journals across the EU, stimulating considerable interest from the wider EU community. The Healthy Aims Team includes the following:

Research Groups in micro and nano technology Biomaterials experts RF Communications experts Power sources experts Design teams Medical Device manufacturers Surgeons and clinical teams, including ethics

These all came from the NEXUS Medical Devices USC and includes 6 SMEs from across the EU.

HEALTHY AIMSNano scale materials and sensors and microsystems for medical implants improving health and quality of life


Contact

Diana Hodgins

EUROPEAN TECHNOLOGY FOR BUSINESS LIMITED

Codicote Innovation Centre

St. Albans Rd, Codicote, Herts SG4 8WH

UNITED KINGDOM


Web site

http://www.healthyaims.org/

Timeline

Start: 1 December 2003

End: 30 November 2007

Budget



Project Partners

EUROPEAN TECHNOLOGY FOR BUSINESS LIMITED UK

ASSUTA MEDICAL CENTERS LTD. IL

CAMPUS MICRO TECHNOLOGIES GMBH D

COCHLEAR EUROPE LIMITED UK

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH

UNIVERSITAT ROVIRA I VIRGILI E

FINETECH MEDICAL LIMITED UK

HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE

FORSCHUNG E.V. D

IIP - TECHNOLOGIES GMBH D

INSTYTUT TECHNOLOGII ELEKTRONOWEJ PL

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW B

MEDIPLUS LIMITED UK

MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIES MBH D

THE NEXUS ASSOCIATION F

NORTH BRISTOL NATIONAL HEALTH SERVICE TRUST UK

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viSiONMixed integrated circuit technology and biotechnology represent a rapidly expanding field. The resulting com-bination of sensing, actuating, interfacing and intelligent processing provides implantable devices the perspective to efficiently compensate for failing organs. Bi-directional telemetry-controlled implanted micro-systems will repre-sent a real breakthrough in healthcare and more specifical-ly in functional electrical stimulation (FES). The afferent branch of a control loop is essential for matching respons-es to ongoing activity as well as automatically avoiding stimulation damage. Such systems will in addition collect information directly leading to further development of communications means with the nervous system. The IM-ANE research project aims at gathering the heterogeneous technologies that should concur at meeting these require-ments at a highly competitive level.

AiMA new silicone rubber metallization process and elec-trode surface treatment will be developed with the ex-

pected result of a miniature nerve electrode holding a high density of well characterised contacts for interfac-ing biological tissues. An experimental study of the cor-relation between neural status and damage should yield the data required to implement safety rules in the control loop of implanted devices. This feature will contribute to eliminate the decoupling capacitors usually placed at the stimulator output where they impede miniaturisation by their volume and by the wasted voltage drop they intro-duce. An active neural recording chain will be integrated in the final electrode to give a direct access to the neural activity. An improved encapsulation technique will be applied to the embedded electronics and completed by a new electrode assembly method.

ExpEctED rESULtSA single application, namely the treatment of epilepsy by vagus nerve stimulation, is included in the project as a practical lead. However, the main developments foreseen are generic and therefore expected to be applicable in a broad range of FES medical devices.

IMANEImplantable Multicontact Active Nerve Electrode


Contact

Jean Delbeke

Universit catholique de Louvain

Avenue Hippocrate, 54 PB-54.46

B-1200 Brussels

BELGIUM


Timeline


End: 31 December 2008

Budget



Project Partners

Universit catholique de Louvain - B

Ghent University B

University College London UK

University of Bath UK

Centre National de la Recherche Scientifique F

Applied Microengineering Limited UK

NEUROTECH B

MATRA ELECTRONIQUE - F

STR

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viSiON & AiMBiochip technology allows assessing the expression of thousands of genes in parallel, opening the way to indi-vidualised healthcare. The INDIGO project will replace the current bulky and expensive technology used to hy-bridise and read fluorescent biochips by a lab-on-chip ap-proach, with integrated signal processing and networking capacities. The project reconsiders the complete biochip user chain, and optimises each component in relation to others. At the core of INDIGO is an innovative, miniature and highly sensitive, yet disposable fluorescence-based biosensor. It replaces the usual glass slide supporting the biological reaction by a sandwich of chemical and opti-cal layers monolithically grafted on a Solid-State Image Sensor. Intermediate layers play an essential optical role for guiding and filtering light. The upper side of the sen-sor is devoted to biology, the inner side to imaging by direct, efficient light collection by the pixels. Improving

signal level will enhance the sensitivity and robustness of the biological measurements. Such a lensless imaging de-vice produces images with new characteristics, and needs development of new data processing software. The image produced by the sensor will be read in a laptop-connected readout head, and then filtered, segmented and measured; the results will be normalised, written in a standard for-mat, ready to be recorded into a database or transmitted through networks. With its user-friendly interface, the system will undergo clinical validation in biology labs, on samples from patients with different cancers and cardio-vascular diseases. The INDIGO project is well suited to the joint IST and NMP call on bio-sensors for Diagnosis and Healthcare. On the NMP side, smart and hybrid materials with extreme characteristics, able to be industrially coated as thin layers will be developed. On the IST side, new data treatment chain will give standardised biological data us-able by the medical community at large.

INDIGOIntegrated highly sensitive fluorescence-based biosensor for diagnosis applications Environments


Contact

Gilles BOUCHARLAT

ATMEL-Grenoble SAS

Avenue de Rochepleine BP 123

38521 SAINT EGREVE

FRANCE


Web site

www.indigo-project.net

Timeline

Start: 1 August 2005

End: 31 July 2008

Budget



Project Partners

ATMEL-Grenoble SAS F

GENEWAVE F

Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei

Materiali I

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES

ET PROCESSUS INDUSTRIELS F

Fundacin Centro Nacional de Investigaciones Cardiovasculares Carlos

III E

FUNDACIN VALENCIANA DE INVESTIGACIONES BIOMDICAS - E

STR

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Contact

Andy Wolff

ASSUTA MEDICAL CENTERS LTD. Hospital Dentistry

62 JABOTINSKY ST.

62748 TEL AVIV - ISRAEL


Web site

http://www.intellidrug.org

Timeline



Budget



Project Partners

ASSUTA MEDICAL CENTERS LTD. IL

FRAUNHOFER GESELLSCHAFT ZUR FERDERUNG DER ANGEWANDTEN

FORSCHUNG E.V. D

RELSOFT SYSTEMS LTD. IL

HAHN-SCHICKARD-GESELLSCHAFT FER ANGEWANDTE

FORSCHUNG E.V. D

VALTRONIC SA CH

POLITECHNIKA WARSZAWSKA PL

UNIVERSIT DEGLI STUDI DI PALERMO I

BIO-DAR LTD IL

MEDICAL TECHNOLOGY PROMEDT CONSULTING GMBH D

ASM - CENTRUM BADAN I ANALIZ RYNKU SP. Z.O.O. PL

HOSPITAL CLNICO SAN CARLOS DE MADRID INSALUD E

CHARIT - UNIVERSITTSMEDIZIN BERLIN D

UNIVERSIT DEGLI STUDI DI NAPOLI FEDERICO II I

ISRAEL ANTI DRUG AUTHORITY IL

TELEFNICA INVESTIGACIN Y DESARROLLO E

STR

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viSiON & AiMIntelliDrug is aimed at developing an intelligent mi-cro- and nano- system to provide an alternative ap-proach for the treatment of addiction and chronic dis-eases. Drug addiction and chronic diseases are among the most severe human problems. Drug addiction itself is a major motive of crime and social instability. The continuous and end-less efforts required from treating personnel and the afflicted persons further compromise the quality of life and give rise to se-vere compliance problems with therapy. In addition, limited effectiveness and adverse side effects are the result of the currently used medication adminis-tration methods. The pro-posed project IntelliDrug is aimed at obviating these problems.The proposed innovation will be reached by develop-ing an intraoral micro-system, which contains a medi-cation replacement reservoir and releases the medica-tion in a controlled, intelligent manner according to the patient needs, in periods lasting days, weeks or months. The device will be reloaded in a simple non-invasive way. The micro-system comprises a medica-

tion release mechanism, a built-in intelligence, micro-sensors and micro-actuators, and a remote control.The objectives of the IST Work Programme will be achieved, as this project explores the application po-tential of micro-nano technology and investigates the integration technologies required to establish the nano

to macro interface and to have nano interact with the ambient. IntelliDrug deals with research and de-velopment of key technol-ogies, such as biosensors and secure communica-tion, low volume control-led drug handling, and the component integration into wearable systems, to manage health status. The resulting micro-system will help afflicted persons to put an end to their per-sonal misery, to run a life

as close as possible to normal and even to turn into a productive member of our society. It also will con-tribute to strengthen European research, cooperation and industry.

prELiMiNAry rESULtSThe project is in prototype phase. The system was tested in vivo on pigs in a controlled study. Naltrex-

INTELLIDRUGIntelligent intraoral medicine delivery micro-system to treat addiction and chronic diseases

Image courtesy of project INTELLIDRUG.

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one, a drug used to treat addiction, was delivered by the system to the buccal (cheek) mucosa during 10 minutes or was injected conventionally into the vein (i. v.) and its blood levels assessed during 6 hours. Administration of i. v. naltrexone induced a sharp increase in blood levels after 5 minutes, and then a steep decrease. In contrast, buccal delivery resulted in a gradual increase in blood naltrexone levels, reaching its peak after 90 minutes,

and followed by a slow decrease. After 6 hours the blood level of naltrexone delivered to the buccal mucosa was significantly higher compared to i. v. administration. To be effective in the treatment of drug addicts, blood levels of naltrexone should be kept constantly above 2ng/ml, a goal that can be reached by the IntelliDrug system simply by adjusting the release rate (dosage and timing) through a command delivered to its software.

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Contact

Blanca Jordan

ATOS ORIGIN sae

ALBARRACIN 25

28037 MADRID

SPAIN


Timeline

Start: 1 June 2006

End: 31 May 2009

Budget



Project Partners

ATOS ORIGIN sae - E

Commissariat lEnergie Atomique F

BioVisioN AG D

FOUNDATION FOR RESEARCH AND TECHNOLOGY-HELLAS GR

Gastrointestinal Molecular Cell Biology (GMZ) Department of Medicine B

Westfaelische Wilhelms-Universitaet D

Swiss Institute of Bioinformatics CH

Geneva Bioinformatics (GeneBio) SA CH

viSiON & AiMThe human plasma proteome holds the promise of a revolution in disease diagnosis and therapy. One major breakthrough should come from the detection of mul-tiprotein disease markers including isoforms. We pro-pose to integrate a full proteomics analysis chain, from blood sample to the diagnosis information, combining bio-, nano, and information-related technologies. It in-cludes an innovative patented lab-on-chip developed at CEA. The clinical application is early pancreatic cancer diagnosis. The project is based on a panel of 3 identi-fied proteins, a protein isolation protocol, an optimised chromatographic-electrospray lab-on-chip, an Integrated Clinico-Proteomics Environment including a Proteomic Information Management System, a Clinical Information System, and modules for preprocessing, reconstruction, visualisation, protein identification, data mining and knowledge discovery. The clinical validation is applied to a cohort of 92 patients. Our targeted performance is

to get at least the sensitivity of an orthogonal ELISA ap-proach, to operate the analysis chain in less than 12 hours, and to demonstrate the interest of multiprotein marker. The main research outcomes will be an optimised chro-matographic-electrospray lab-on-chip, a software en-vironment supporting the integrated device, a proof-of-concept of their application to protein profiling for cancer diagnosis and an exploitation plan. The roadmap of this 36 months project is defined according to three main milestones: 1) at month 12, a first protein profile us-ing a first version of the lab-on-chip on artificial samples is available, 2) at month 24, all the final versions of the sub-systems are ready for integration and validation, 3) at month 33, the validation on clinical samples is com-pleted. The consortium partnership involves partners over 5 countries, combining basic and applied research (CEA, FORTH, SIB, WWU), 1 large company (ATOS) and 2 SMEs (BVN, GB), including clinicians and end-us-ers (WWU, BVN).

LOCCANDIALab-On-Chip based protein profiling for CANcer DIAgnosis

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Contact

Wim Laureyn

Interuniversitair Micro-Elektronica

Centrum vzw

Kapeldreef 75

3001 Leuven

BELGIUM


Timeline



Budget



Project Partners

Interuniversitair Micro-Elektronica Centrum vzw B

Universitat Rovira i Virgili E

CanAg Diagnostics AB SE

Institut fr Mikrotechnik Mainz GmbH D

AdnaGen AG D

Rikshospitalet-Radiumhospitalet- HF NO

MRC-Holland BV NL

viSiON & AiMThe overall objective of MASCOT is to exploit break-throughs at the confluences of micro-, nano- and bio-technologies to create a low-cost minimally-invasive in-telligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of rare cells from complex mixtures and using an array of nano-biosensors, integrated with micro-scale amplification, for the consecutive RNA/DNA analysis of the isolated rare cells. Advances in molecular biology and biosensor tech-nology and the integration of nano-structured functional components in macro- and microsystems will facilitate the isolation of rare cells on the basis of novel markers, cell size, tailored surface chemistry and labelling with magnetic beads. The advantages of the exploited biosen-

sors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effec-tiveness. Addressing the health care requirement of the future of an individualised theranostic approach, the spe-cific applications that will be demonstrated in MASCOT will be the isolation and RNA/DNA characterisation of both breast and lung cancer cells (more specifically, circulating tumour cells or CTCs), from respectively pe-ripheral blood or bone marrow and sputum. The radical innovation proposed in MASCOT will result in a con-crete prime deliverable of a technology platform of wide application and unquestionable socio-economic benefit, increasing European competitiveness whilst contributing considerably to the quality of life of the population and control of health care cost.

MASCOTIntegrated Microsystem for the Magnetic Isolation and Analysis of Single Circulating Tumour Cells for Oncology Diagnostics and Therapy Follow-up

STR

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Biosensor arraysfor DNA detection

Microsystemfor RNA extraction

& amplifications

Microsystemfor imuno-magnetic cell

isolation & detection

DNAdetection

RNA extration& amplification

Cell isolation& detection

Novel mRNA markersfor CTC characterisation

Novel CTC suface markersfor immuno-separation

INTEGRATION

Documents

g2-proj-portfolio_en.pdf