Funnel plot with pseudo 95% confidence limits · 2017. 2. 28. · Overall (I-squared = 0.0%, p = 0.603) Engeland_2004 Lindblad_2005 Studyauthor_year MacInnis_2006 Lindblad_2005 Samanic_2006

NOTE: Weights are from random effects analysis

Overall (I-squared = 0.0%, p = 0.603)

Engeland_2004

Lindblad_2005

Studyauthor_year

MacInnis_2006

Lindblad_2005

Samanic_2006

Engeland_2004

Oh_2005

Reeves_2007

1.54 (1.41, 1.67)

1.48 (1.16, 1.88)

1.46 (0.98, 2.18)

ES (95% CI)

1.63 (1.08, 2.47)

1.45 (1.09, 1.93)

1.60 (1.17, 2.18)

1.67 (1.45, 1.93)

1.14 (0.84, 1.54)

1.54 (1.26, 1.89)

100.00

12.68

4.57

Weight

4.32

9.06

7.63

35.72

8.05

17.98

%

1.54 (1.41, 1.67)

1.48 (1.16, 1.88)

1.46 (0.98, 2.18)

ES (95% CI)

1.63 (1.08, 2.47)

1.45 (1.09, 1.93)

1.60 (1.17, 2.18)

1.67 (1.45, 1.93)

1.14 (0.84, 1.54)

1.54 (1.26, 1.89)

100.00

12.68

4.57

Weight

4.32

9.06

7.63

35.72

8.05

17.98

%

1.406 1 2.47

0.0

5.1

.15

.2s.e

. of lo

g(S

tudy R

R)

0 .2 .4 .6 .8log(Study RR)

Funnel plot with pseudo 95% confidence limits

BMI per 5kg/m2: Oeophageal adenocarcinoma inc, overall



Studyauthor_year

Engeland_2004

Samanic_2006

Oh_2005

Lindblad_2005

MacInnis_2006

1.52 (1.33, 1.74)

ES (95% CI)

1.67 (1.45, 1.93)

1.60 (1.17, 2.18)

1.14 (0.84, 1.54)

1.45 (1.09, 1.93)

1.63 (1.08, 2.47)

100.00

Weight

41.94

15.26

15.92

17.48

9.41

%

1.52 (1.33, 1.74)

ES (95% CI)

1.67 (1.45, 1.93)

1.60 (1.17, 2.18)

1.14 (0.84, 1.54)

1.45 (1.09, 1.93)

1.63 (1.08, 2.47)

100.00

Weight

41.94

15.26

15.92

17.48

9.41

%

1.406 1 2.47

0.0

5.1

.15

.2s.e

. of lo

g(S

tudy R

R)

0 .2 .4 .6 .8log(Study RR)


BMI per 5kg/m2: Oesophageal adenocarcinoma inc, men



Lindblad_2005

Engeland_2004

Studyauthor_year

Reeves_2007

1.51 (1.30, 1.74)

1.46 (0.98, 2.18)

1.48 (1.16, 1.88)

ES (95% CI)

1.54 (1.26, 1.89)

100.00

12.98

35.99

Weight

%

51.04

1.51 (1.30, 1.74)

1.46 (0.98, 2.18)

1.48 (1.16, 1.88)

ES (95% CI)

1.54 (1.26, 1.89)

100.00

12.98

35.99

Weight

%

51.04

1.458 1 2.18

0.0

5.1

.15

.2s.e

. of lo

g(S

tudy R

R)

0 .2 .4 .6 .8log(Study RR)


BMI per 5kg/m2: Oesophageal adenocarcinoma inc, women



Engeland_2004

Reeves_2007

Oh_2005

Samanic_2006

Studyauthor_year

Engeland_2004

0.63 (0.53, 0.75)

0.61 (0.54, 0.69)

0.51 (0.42, 0.61)

0.47 (0.27, 0.82)

0.69 (0.56, 0.85)

ES (95% CI)

0.77 (0.70, 0.85)

100.00

24.65

21.52

7.34

20.27

Weight

26.22

%

0.63 (0.53, 0.75)

0.61 (0.54, 0.69)

0.51 (0.42, 0.61)

0.47 (0.27, 0.82)

0.69 (0.56, 0.85)

ES (95% CI)

0.77 (0.70, 0.85)

100.00

24.65

21.52

7.34

20.27

Weight

26.22

%

1.27 1 3.71

0.1

.2.3

s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5log(Study RR)


BMI per 5kg/m2: Oesophageal squamous cell carcinoma inc, overall



Studyauthor_year

Samanic_2006

Oh_2005

Engeland_2004

0.71 (0.61, 0.84)

ES (95% CI)

0.69 (0.56, 0.85)

0.47 (0.27, 0.82)

0.77 (0.70, 0.85)

100.00

Weight

%

33.71

7.86

58.43

0.71 (0.61, 0.84)

ES (95% CI)

0.69 (0.56, 0.85)

0.47 (0.27, 0.82)

0.77 (0.70, 0.85)

100.00

Weight

%

33.71

7.86

58.43

1.27 1 3.71

0.1

.2.3

s.e

. of lo

g(S

tudy R

R)

-.8 -.6 -.4 -.2 0 .2log(Study RR)


BMI per 5kg/m2: Oesophageal squamous cell carcinoma inc, men



Reeves_2007

Engeland_2004

Studyauthor_year

0.57 (0.48, 0.67)

0.51 (0.42, 0.61)

0.61 (0.54, 0.69)

ES (95% CI)

100.00

42.70

%

57.30

Weight

0.57 (0.48, 0.67)

0.51 (0.42, 0.61)

0.61 (0.54, 0.69)

ES (95% CI)

100.00

42.70

%

57.30

Weight

1.423 1 2.36

0.0

2.0

4.0

6.0

8.1

s.e

. of lo

g(S

tudy R

R)

-.7 -.6 -.5 -.4 -.3log(Study RR)


BMI per 5kg/m2: Oesophageal squamous cell carcinoma inc, women



Reeves_2007

Rapp_2005

Rapp_2005

Kuriyama_2005

Lukanova_2006

Lindblad_2005

Kuriyama_2005

Studyauthor_year

MacInnis_2006

Samanic_2006

Lukanova_2006

Oh_2005

Tulinius_1997

Lindblad_2005

0.99 (0.92, 1.06)

0.95 (0.86, 1.05)

0.93 (0.74, 1.17)

1.06 (0.88, 1.27)

1.26 (0.94, 1.68)

1.18 (0.75, 1.86)

1.39 (0.87, 2.23)

1.05 (0.83, 1.32)

ES (95% CI)

0.95 (0.70, 1.29)

1.10 (0.91, 1.33)

0.70 (0.36, 1.37)

0.95 (0.90, 1.00)

0.71 (0.57, 0.89)

1.18 (0.82, 1.70)

100.00

17.74

7.13

9.69

4.92

2.25

2.08

7.09

Weight

4.52

9.28

1.09

%

23.71

7.16

3.34

0.99 (0.92, 1.06)

0.95 (0.86, 1.05)

0.93 (0.74, 1.17)

1.06 (0.88, 1.27)

1.26 (0.94, 1.68)

1.18 (0.75, 1.86)

1.39 (0.87, 2.23)

1.05 (0.83, 1.32)

ES (95% CI)

0.95 (0.70, 1.29)

1.10 (0.91, 1.33)

0.70 (0.36, 1.37)

0.95 (0.90, 1.00)

0.71 (0.57, 0.89)

1.18 (0.82, 1.70)

100.00

17.74

7.13

9.69

4.92

2.25

2.08

7.09

Weight

4.52

9.28

1.09

%

23.71

7.16

3.34

1.359 1 2.79

0.1

.2.3

.4s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Gastric cancer inc, overall



Studyauthor_year

Rapp_2005

Lukanova_2006

Lindblad_2005

Tulinius_1997

Samanic_2006

Oh_2005

MacInnis_2006

Kuriyama_2005

0.97 (0.88, 1.06)

ES (95% CI)

0.93 (0.74, 1.17)

1.18 (0.75, 1.86)

1.18 (0.82, 1.70)

0.71 (0.57, 0.89)

1.10 (0.91, 1.33)

0.95 (0.90, 1.00)

0.95 (0.70, 1.29)

1.05 (0.83, 1.32)

100.00

Weight

11.62

3.86

5.66

11.67

14.82

33.22

%

7.57

11.58

0.97 (0.88, 1.06)

ES (95% CI)

0.93 (0.74, 1.17)

1.18 (0.75, 1.86)

1.18 (0.82, 1.70)

0.71 (0.57, 0.89)

1.10 (0.91, 1.33)

0.95 (0.90, 1.00)

0.95 (0.70, 1.29)

1.05 (0.83, 1.32)

100.00

Weight

11.62

3.86

5.66

11.67

14.82

33.22

%

7.57

11.58

1.538 1 1.86

0.0

5.1

.15

.2.2

5s.e

. of lo

g(S

tudy R

R)

-.6 -.4 -.2 0 .2 .4log(Study RR)


BMI per 5kg/m2: Gastric cancer inc, men



Studyauthor_year

Lindblad_2005

Lukanova_2006

Reeves_2007

Kuriyama_2005

Rapp_2005

1.04 (0.91, 1.21)

ES (95% CI)

1.39 (0.87, 2.23)

0.70 (0.36, 1.37)

0.95 (0.86, 1.05)

1.26 (0.94, 1.68)

1.06 (0.88, 1.27)

100.00

Weight

7.76

4.21

42.76

%

16.71

28.56

1.04 (0.91, 1.21)

ES (95% CI)

1.39 (0.87, 2.23)

0.70 (0.36, 1.37)

0.95 (0.86, 1.05)

1.26 (0.94, 1.68)

1.06 (0.88, 1.27)

100.00

Weight

7.76

4.21

42.76

%

16.71

28.56

1.359 1 2.79

0.1

.2.3

.4s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Gastric cancer inc, women



Murphy_2000

Kuriyama_2005

Tamakoshi_2004

Kuriyama_2005

Rapp_2005

Ford_1999

Shimizu_2003

Chyou_1994

Larsson_2006

Pischon_2006

Colangelo_2002

MacInnis_2006

Samanic_2006

Singh_1998

Shimizu_2003

Studyauthor_year

Terry_2001

Otani_2005

Engeland_2005

Lukanova_2005

Thune_1996

Wei_2004_women

Oh_2005

Colangelo_2002

Bowers_2006

Lukanova_2005

Otani_2005

Murphy_2000

Engeland_2005

Lee_1992

Moore_2004

Batty_2005

Eichholzer_2005

Lin_2004

Thune_1996

Wei_2004_men

Moore_2004

Ford_1999

MacInnis_2004

Tamakoshi_2004

Rapp_2005

Terry_2002

Singh_1998

Bostick_1994

Pischon_2006

1.22 (1.17, 1.28)

1.11 (1.03, 1.19)

1.28 (0.79, 2.08)

2.00 (1.30, 3.08)

1.42 (0.97, 2.07)

1.04 (0.90, 1.20)

1.46 (1.00, 2.13)

1.65 (1.14, 2.39)

1.19 (0.95, 1.49)

1.20 (1.02, 1.42)

1.10 (1.00, 1.21)

0.99 (0.78, 1.26)

1.04 (0.90, 1.20)

1.36 (1.26, 1.47)

1.04 (0.72, 1.50)

1.21 (0.74, 1.98)

ES (95% CI)

1.12 (1.02, 1.23)

1.36 (1.13, 1.64)

1.03 (1.01, 1.05)

1.17 (0.78, 1.76)

0.96 (0.75, 1.23)

1.10 (1.03, 1.18)

1.22 (1.09, 1.37)

1.27 (1.01, 1.60)

1.43 (1.00, 2.04)

1.40 (0.96, 2.04)

0.98 (0.77, 1.24)

1.40 (1.28, 1.53)

1.27 (1.23, 1.31)

1.47 (1.19, 1.81)

1.75 (1.16, 2.65)

1.41 (1.10, 1.81)

1.54 (0.73, 3.24)

1.40 (1.16, 1.68)

1.12 (1.01, 1.24)

1.38 (1.20, 1.59)

1.35 (1.07, 1.71)

1.76 (1.19, 2.61)

1.29 (1.04, 1.60)

0.71 (0.41, 1.23)

1.30 (1.09, 1.55)

1.03 (0.89, 1.19)

1.46 (0.84, 2.54)

1.25 (1.07, 1.46)

1.28 (1.11, 1.47)

100.00

3.80

0.81

0.97

1.19

3.04

1.19

1.21

2.19

2.80

3.53

2.06

3.04

3.76

1.25

0.79

Weight

3.61

2.54

4.12

1.06

2.00

3.84

3.37

2.15

1.28

1.20

2.08

3.64

4.08

2.34

1.03

1.96

0.38

2.60

3.50

3.08

2.09

1.12

2.28

0.65

2.72

3.03

0.65

2.91

3.08

%

1.22 (1.17, 1.28)

1.11 (1.03, 1.19)

1.28 (0.79, 2.08)

2.00 (1.30, 3.08)

1.42 (0.97, 2.07)

1.04 (0.90, 1.20)

1.46 (1.00, 2.13)

1.65 (1.14, 2.39)

1.19 (0.95, 1.49)

1.20 (1.02, 1.42)

1.10 (1.00, 1.21)

0.99 (0.78, 1.26)

1.04 (0.90, 1.20)

1.36 (1.26, 1.47)

1.04 (0.72, 1.50)

1.21 (0.74, 1.98)

ES (95% CI)

1.12 (1.02, 1.23)

1.36 (1.13, 1.64)

1.03 (1.01, 1.05)

1.17 (0.78, 1.76)

0.96 (0.75, 1.23)

1.10 (1.03, 1.18)

1.22 (1.09, 1.37)

1.27 (1.01, 1.60)

1.43 (1.00, 2.04)

1.40 (0.96, 2.04)

0.98 (0.77, 1.24)

1.40 (1.28, 1.53)

1.27 (1.23, 1.31)

1.47 (1.19, 1.81)

1.75 (1.16, 2.65)

1.41 (1.10, 1.81)

1.54 (0.73, 3.24)

1.40 (1.16, 1.68)

1.12 (1.01, 1.24)

1.38 (1.20, 1.59)

1.35 (1.07, 1.71)

1.76 (1.19, 2.61)

1.29 (1.04, 1.60)

0.71 (0.41, 1.23)

1.30 (1.09, 1.55)

1.03 (0.89, 1.19)

1.46 (0.84, 2.54)

1.25 (1.07, 1.46)

1.28 (1.11, 1.47)

100.00

3.80

0.81

0.97

1.19

3.04

1.19

1.21

2.19

2.80

3.53

2.06

3.04

3.76

1.25

0.79

Weight

3.61

2.54

4.12

1.06

2.00

3.84

3.37

2.15

1.28

1.20

2.08

3.64

4.08

2.34

1.03

1.96

0.38

2.60

3.50

3.08

2.09

1.12

2.28

0.65

2.72

3.03

0.65

2.91

3.08

%

1.308 1 3.24

0.1

.2.3

.4s.e

. o

f lo

g(S

tud

y R

R)

-.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Colon cancer inc, overall



Moore_2004

MacInnis_2006

Giovannucci_1995

Pischon_2006

Larsson_2006

Moore_2004

Pischon_2006

MacInnis_2004

Studyauthor_year

1.25 (1.15, 1.35)

1.52 (1.23, 1.87)

1.14 (1.02, 1.28)

1.46 (1.19, 1.80)

1.21 (0.81, 1.80)

1.15 (1.01, 1.31)

1.28 (1.06, 1.54)

1.14 (1.04, 1.24)

1.37 (1.18, 1.60)

ES (95% CI)

100.00

9.28

17.43

9.43

3.38

15.64

10.84

20.50

13.49

Weight

%

1.25 (1.15, 1.35)

1.52 (1.23, 1.87)

1.14 (1.02, 1.28)

1.46 (1.19, 1.80)

1.21 (0.81, 1.80)

1.15 (1.01, 1.31)

1.28 (1.06, 1.54)

1.14 (1.04, 1.24)

1.37 (1.18, 1.60)

ES (95% CI)

100.00

9.28

17.43

9.43

3.38

15.64

10.84

20.50

13.49

Weight

%

1.534 1 1.87

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


WC per 10 cm: Colon cancer inc, overall



Studyauthor_year

Thygesen_2008

Laake_2010

Aleksandrova_2013

Laake_2010

Bassett_2010

Bassett_2010

Aleksandrova_2013

1.07 (1.03, 1.10)

ES (95% CI)

1.10 (1.03, 1.17)

1.08 (0.92, 1.27)

1.04 (0.95, 1.14)

1.06 (0.90, 1.24)

1.00 (0.93, 1.07)

1.11 (1.03, 1.19)

1.07 (0.98, 1.16)

100.00

Weight

25.18

3.75

12.30

3.98

20.80

19.61

14.38

%

1.07 (1.03, 1.10)

ES (95% CI)

1.10 (1.03, 1.17)

1.08 (0.92, 1.27)

1.04 (0.95, 1.14)

1.06 (0.90, 1.24)

1.00 (0.93, 1.07)

1.11 (1.03, 1.19)

1.07 (0.98, 1.16)

100.00

Weight

25.18

3.75

12.30

3.98

20.80

19.61

14.38

%

1.785 1 1.27

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

-.1 0 .1 .2 .3log(Study RR)


WG per 5kg: Colon cancer inc, overall



Martinez_1997

MacInnis_2004

Giovannucci_1995

Larsson_2006

Bostick_1994

Studyauthor_year

Pischon_2006

MacInnis_2006

Pischon_2006

1.29 (1.17, 1.43)

1.29 (0.97, 1.72)

1.78 (1.39, 2.27)

1.66 (1.08, 2.56)

1.30 (1.06, 1.60)

1.04 (0.88, 1.22)

ES (95% CI)

1.24 (1.05, 1.46)

1.31 (1.08, 1.58)

1.24 (1.10, 1.39)

100.00

8.58

10.49

4.62

12.62

15.51

Weight

15.41

%

13.62

19.15

1.29 (1.17, 1.43)

1.29 (0.97, 1.72)

1.78 (1.39, 2.27)

1.66 (1.08, 2.56)

1.30 (1.06, 1.60)

1.04 (0.88, 1.22)

ES (95% CI)

1.24 (1.05, 1.46)

1.31 (1.08, 1.58)

1.24 (1.10, 1.39)

100.00

8.58

10.49

4.62

12.62

15.51

Weight

15.41

%

13.62

19.15

1.391 1 2.56

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


WHR per 0.1 units: Colon cancer inc, overall



Ford_1999

Wei_2004_men

Colangelo_2002

Otani_2005

Singh_1998

Batty_2005

Eichholzer_2005

Rapp_2005

Engeland_2005

Bowers_2006

Murphy_2000

Larsson_2006

Lukanova_2005

Tamakoshi_2004

Oh_2005

Kuriyama_2005

Pischon_2006

Moore_2004

MacInnis_2004

Shimizu_2003

Samanic_2006

Lee_1992

Chyou_1994

Studyauthor_year

Thune_1996

1.30 (1.25, 1.35)

1.76 (1.19, 2.61)

1.38 (1.20, 1.59)

1.27 (1.01, 1.60)

1.36 (1.13, 1.64)

1.46 (0.84, 2.54)

1.41 (1.10, 1.81)

1.54 (0.73, 3.24)

1.30 (1.09, 1.55)

1.27 (1.23, 1.31)

1.43 (1.00, 2.04)

1.40 (1.28, 1.53)

1.20 (1.02, 1.42)

1.17 (0.78, 1.76)

0.71 (0.41, 1.23)

1.22 (1.09, 1.37)

1.28 (0.79, 2.08)

1.28 (1.11, 1.47)

1.75 (1.16, 2.65)

1.29 (1.04, 1.60)

1.65 (1.14, 2.39)

1.36 (1.26, 1.47)

1.47 (1.19, 1.81)

1.19 (0.95, 1.49)

ES (95% CI)

1.12 (1.01, 1.24)

100.00

0.88

5.49

2.39

3.38

0.45

2.03

0.25

3.94

20.59

1.06

10.20

4.24

0.82

0.45

7.44

0.59

5.50

0.79

2.69

%

0.97

11.94

2.82

2.49

Weight

8.60

1.30 (1.25, 1.35)

1.76 (1.19, 2.61)

1.38 (1.20, 1.59)

1.27 (1.01, 1.60)

1.36 (1.13, 1.64)

1.46 (0.84, 2.54)

1.41 (1.10, 1.81)

1.54 (0.73, 3.24)

1.30 (1.09, 1.55)

1.27 (1.23, 1.31)

1.43 (1.00, 2.04)

1.40 (1.28, 1.53)

1.20 (1.02, 1.42)

1.17 (0.78, 1.76)

0.71 (0.41, 1.23)

1.22 (1.09, 1.37)

1.28 (0.79, 2.08)

1.28 (1.11, 1.47)

1.75 (1.16, 2.65)

1.29 (1.04, 1.60)

1.65 (1.14, 2.39)

1.36 (1.26, 1.47)

1.47 (1.19, 1.81)

1.19 (0.95, 1.49)

ES (95% CI)

1.12 (1.01, 1.24)

100.00

0.88

5.49

2.39

3.38

0.45

2.03

0.25

3.94

20.59

1.06

10.20

4.24

0.82

0.45

7.44

0.59

5.50

0.79

2.69

%

0.97

11.94

2.82

2.49

Weight

8.60

1.308 1 3.24

0.1

.2.3

.4s.e

. o

f lo

g(S

tud

y R

R)



BMI per 5kg/m2: Colon cancer inc, men



Pischon_2006

Giovannucci_1995

Studyauthor_year

MacInnis_2004

Larsson_2006

Moore_2004

1.33 (1.18, 1.50)

1.21 (0.81, 1.80)

1.46 (1.19, 1.80)

ES (95% CI)

1.37 (1.18, 1.60)

1.15 (1.01, 1.31)

1.52 (1.23, 1.87)

100.00

%

7.22

18.87

Weight

25.91

29.41

18.60

1.33 (1.18, 1.50)

1.21 (0.81, 1.80)

1.46 (1.19, 1.80)

ES (95% CI)

1.37 (1.18, 1.60)

1.15 (1.01, 1.31)

1.52 (1.23, 1.87)

100.00

%

7.22

18.87

Weight

25.91

29.41

18.60

1.534 1 1.87

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


WC per 10 cm: Colon cancer inc, men



Larsson_2006

Giovannucci_1995

Pischon_2006

MacInnis_2004

Studyauthor_year

1.43 (1.19, 1.71)

1.30 (1.06, 1.60)

1.66 (1.08, 2.56)

1.24 (1.05, 1.46)

1.78 (1.39, 2.27)

ES (95% CI)

100.00

28.91

12.52

33.50

25.06

Weight

%

1.43 (1.19, 1.71)

1.30 (1.06, 1.60)

1.66 (1.08, 2.56)

1.24 (1.05, 1.46)

1.78 (1.39, 2.27)

ES (95% CI)

100.00

28.91

12.52

33.50

25.06

Weight

%

1.391 1 2.56

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6 .8log(Study RR)


WHR per 0.1 units: Colon cancer inc, men



Laake_2010

Studyauthor_year

Bassett_2010

Aleksandrova_2013

Thygesen_2008

1.09 (1.05, 1.14)

1.08 (0.92, 1.27)

ES (95% CI)

1.11 (1.03, 1.19)

1.04 (0.95, 1.14)

1.10 (1.03, 1.17)

100.00

6.16

%

Weight

32.24

20.22

41.38

1.09 (1.05, 1.14)

1.08 (0.92, 1.27)

ES (95% CI)

1.11 (1.03, 1.19)

1.04 (0.95, 1.14)

1.10 (1.03, 1.17)

100.00

6.16

%

Weight

32.24

20.22

41.38

1.785 1 1.27

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

-.1 0 .1 .2 .3log(Study RR)


WG per 5kg: Colon cancer inc, men



Ford_1999

Tamakoshi_2004

Singh_1998

Shimizu_2003

Studyauthor_year

Engeland_2005

Lukanova_2005

Murphy_2000

Wei_2004_women

Moore_2004

Rapp_2005

Terry_2002

Otani_2005

Kuriyama_2005

Colangelo_2002

MacInnis_2006

Bostick_1994

Thune_1996

Pischon_2006

Lin_2004

Terry_2001

1.12 (1.06, 1.17)

1.46 (1.00, 2.13)

2.00 (1.30, 3.08)

1.04 (0.72, 1.50)

1.21 (0.74, 1.98)

ES (95% CI)

1.03 (1.01, 1.05)

1.40 (0.96, 2.04)

1.11 (1.03, 1.19)

1.10 (1.03, 1.18)

1.35 (1.07, 1.71)

1.04 (0.90, 1.20)

1.03 (0.89, 1.19)

0.98 (0.77, 1.24)

1.42 (0.97, 2.07)

0.99 (0.78, 1.26)

1.04 (0.90, 1.20)

1.25 (1.07, 1.46)

0.96 (0.75, 1.23)

1.10 (1.00, 1.21)

1.40 (1.16, 1.68)

1.12 (1.02, 1.23)

100.00

1.46

1.14

1.54

0.89

Weight

13.11

1.47

10.28

10.56

3.16

6.09

%

6.02

3.12

1.45

3.09

6.09

5.58

2.94

8.51

4.52

8.98

1.12 (1.06, 1.17)

1.46 (1.00, 2.13)

2.00 (1.30, 3.08)

1.04 (0.72, 1.50)

1.21 (0.74, 1.98)

ES (95% CI)

1.03 (1.01, 1.05)

1.40 (0.96, 2.04)

1.11 (1.03, 1.19)

1.10 (1.03, 1.18)

1.35 (1.07, 1.71)

1.04 (0.90, 1.20)

1.03 (0.89, 1.19)

0.98 (0.77, 1.24)

1.42 (0.97, 2.07)

0.99 (0.78, 1.26)

1.04 (0.90, 1.20)

1.25 (1.07, 1.46)

0.96 (0.75, 1.23)

1.10 (1.00, 1.21)

1.40 (1.16, 1.68)

1.12 (1.02, 1.23)

100.00

1.46

1.14

1.54

0.89

Weight

13.11

1.47

10.28

10.56

3.16

6.09

%

6.02

3.12

1.45

3.09

6.09

5.58

2.94

8.51

4.52

8.98

1.325 1 3.08

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


BMI per 5kg/m2: Colon cancer inc, women



Moore_2004

MacInnis_2006

Studyauthor_year

Pischon_2006

1.16 (1.08, 1.23)

1.28 (1.06, 1.54)

1.14 (1.02, 1.28)

ES (95% CI)

1.14 (1.04, 1.24)

100.00

12.22

%

32.56

Weight

55.22

1.16 (1.08, 1.23)

1.28 (1.06, 1.54)

1.14 (1.02, 1.28)

ES (95% CI)

1.14 (1.04, 1.24)

100.00

12.22

%

32.56

Weight

55.22

1.649 1 1.54

0.0

2.0

4.0

6.0

8.1

s.e

. o

f lo

g(S

tud

y R

R)

0 .1 .2 .3 .4log(Study RR)


WC per 10 cm: Colon cancer inc, women



Bostick_1994

Studyauthor_year

Pischon_2006

MacInnis_2006

Martinez_1997

1.20 (1.08, 1.33)

1.04 (0.88, 1.22)

ES (95% CI)

1.24 (1.10, 1.39)

1.31 (1.08, 1.58)

1.29 (0.97, 1.72)

100.00

%

26.96

Weight

40.00

21.76

11.28

1.20 (1.08, 1.33)

1.04 (0.88, 1.22)

ES (95% CI)

1.24 (1.10, 1.39)

1.31 (1.08, 1.58)

1.29 (0.97, 1.72)

100.00

%

26.96

Weight

40.00

21.76

11.28

1.582 1 1.72

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


WHR per 0.1 units: Colon cancer inc, women



Laake_2010

Bassett_2010

Aleksandrova_2013

Studyauthor_year

1.03 (0.98, 1.09)

1.06 (0.90, 1.24)

1.00 (0.93, 1.07)

1.07 (0.98, 1.16)

ES (95% CI)

100.00

10.17

%

53.11

36.73

Weight

1.03 (0.98, 1.09)

1.06 (0.90, 1.24)

1.00 (0.93, 1.07)

1.07 (0.98, 1.16)

ES (95% CI)

100.00

10.17

%

53.11

36.73

Weight

1.804 1 1.24

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

-.2 -.1 0 .1 .2log(Study RR)


WG per 5kg: Colon cancer inc, women



Renehan_2012

Han_2014

Laake_2010

Rapp_2008

Renehan_2012

Hughes_2011

Renehan_2012

Laake_2010

Han_2014

Hughes_2011

Aleksandrova_2013

Renehan_2012

Thygesen_2008

Bassett_2010

Rapp_2008

Bassett_2010

Rapp_2008

Studyauthor_year

1.20 (1.10, 1.31)

1.06 (0.91, 1.24)

1.81 (0.14, 23.23)

1.15 (0.86, 1.53)

1.29 (0.68, 2.45)

1.26 (0.94, 1.68)

1.26 (0.92, 1.73)

1.31 (1.18, 1.45)

1.10 (0.83, 1.46)

4.50 (0.79, 25.59)

0.90 (0.69, 1.17)

1.38 (1.14, 1.67)

1.16 (0.97, 1.39)

1.86 (1.21, 2.86)

2.08 (1.21, 3.57)

1.14 (0.82, 1.59)

1.01 (0.60, 1.69)

0.89 (0.58, 1.37)

ES (95% CI)

100.00

12.32

0.12

6.34

1.72

6.28

5.58

15.65

6.41

0.25

7.12

10.43

10.86

3.45

2.33

%

5.13

2.54

3.46

Weight

1.20 (1.10, 1.31)

1.06 (0.91, 1.24)

1.81 (0.14, 23.23)

1.15 (0.86, 1.53)

1.29 (0.68, 2.45)

1.26 (0.94, 1.68)

1.26 (0.92, 1.73)

1.31 (1.18, 1.45)

1.10 (0.83, 1.46)

4.50 (0.79, 25.59)

0.90 (0.69, 1.17)

1.38 (1.14, 1.67)

1.16 (0.97, 1.39)

1.86 (1.21, 2.86)

2.08 (1.21, 3.57)

1.14 (0.82, 1.59)

1.01 (0.60, 1.69)

0.89 (0.58, 1.37)

ES (95% CI)

100.00

12.32

0.12

6.34

1.72

6.28

5.58

15.65

6.41

0.25

7.12

10.43

10.86

3.45

2.33

%

5.13

2.54

3.46

Weight

1.0391 1 25.6

0.5

11

.5s.e

. o

f lo

g(S

tud

y R

R)

-2 -1 0 1 2 3log(Study RR)


WG per 1kg/year: Colorectal cancer inc



Thune_1996

Samanic_2006

Bowers_2006

Terry_2002

Lukanova_2006

MacInnis_2006

Adams_2007

Thune_1996

Adams_2007

Gaard_1997

Studyauthor_year

Pischon_2006

MacInnis_2006

Otani_2005

Engeland_2005

Gaard_1997

Rapp_2005

Engeland_2005

Wei_2004_w

Oh_2005

Larsson_2006

Chyou_1996

Lin_2004

Otani_2005

Kuriyama_2005

Rapp_2005

Lukanova_2006

Pischon_2006

Shimizu_2003

Shimizu_2003

Wei_2004_m

Kuriyama_2005

1.07 (1.03, 1.10)

0.98 (0.71, 1.35)

1.12 (1.04, 1.21)

1.08 (0.93, 1.26)

1.09 (0.88, 1.36)

1.31 (0.91, 1.88)

0.98 (0.79, 1.21)

1.04 (0.94, 1.15)

1.00 (0.78, 1.28)

1.08 (0.96, 1.22)

0.76 (0.52, 1.12)

ES (95% CI)

1.04 (0.89, 1.22)

1.09 (0.86, 1.38)

1.13 (0.79, 1.61)

1.01 (0.98, 1.04)

1.29 (0.83, 2.00)

0.90 (0.74, 1.09)

1.08 (1.05, 1.12)

1.22 (1.02, 1.46)

1.16 (1.04, 1.30)

1.25 (0.99, 1.58)

0.75 (0.55, 1.02)

1.20 (0.87, 1.65)

1.15 (0.80, 1.66)

1.12 (0.67, 1.87)

1.24 (1.00, 1.54)

1.19 (0.71, 1.98)

1.06 (0.89, 1.27)

0.87 (0.51, 1.48)

0.85 (0.39, 1.85)

0.96 (0.71, 1.29)

1.49 (0.98, 2.26)

100.00

0.98

9.78

3.76

2.02

0.77

2.09

7.35

1.64

5.44

0.69

Weight

3.53

1.73

0.80

17.74

0.53

2.48

17.28

2.84

%

5.96

1.77

1.05

0.98

0.76

0.39

2.05

0.40

2.88

0.37

0.17

1.15

0.59

1.07 (1.03, 1.10)

0.98 (0.71, 1.35)

1.12 (1.04, 1.21)

1.08 (0.93, 1.26)

1.09 (0.88, 1.36)

1.31 (0.91, 1.88)

0.98 (0.79, 1.21)

1.04 (0.94, 1.15)

1.00 (0.78, 1.28)

1.08 (0.96, 1.22)

0.76 (0.52, 1.12)

ES (95% CI)

1.04 (0.89, 1.22)

1.09 (0.86, 1.38)

1.13 (0.79, 1.61)

1.01 (0.98, 1.04)

1.29 (0.83, 2.00)

0.90 (0.74, 1.09)

1.08 (1.05, 1.12)

1.22 (1.02, 1.46)

1.16 (1.04, 1.30)

1.25 (0.99, 1.58)

0.75 (0.55, 1.02)

1.20 (0.87, 1.65)

1.15 (0.80, 1.66)

1.12 (0.67, 1.87)

1.24 (1.00, 1.54)

1.19 (0.71, 1.98)

1.06 (0.89, 1.27)

0.87 (0.51, 1.48)

0.85 (0.39, 1.85)

0.96 (0.71, 1.29)

1.49 (0.98, 2.26)

100.00

0.98

9.78

3.76

2.02

0.77

2.09

7.35

1.64

5.44

0.69

Weight

3.53

1.73

0.80

17.74

0.53

2.48

17.28

2.84

%

5.96

1.77

1.05

0.98

0.76

0.39

2.05

0.40

2.88

0.37

0.17

1.15

0.59

1.391 1 2.56

0.1

.2.3

.4s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Rectal cancer inc, overall



Kuriyama_2005

Adams_2007

Wei_2004_m

Rapp_2005

Oh_2005

Pischon_2006

Samanic_2006

Lukanova_2006

MacInnis_2006

Larsson_2006

Studyauthor_year

Shimizu_2003

Engeland_2005

Gaard_1997

Thune_1996

Chyou_1996

Otani_2005

Bowers_2006

1.09 (1.06, 1.13)

1.49 (0.98, 2.26)

1.04 (0.94, 1.15)

0.96 (0.71, 1.29)

1.24 (1.00, 1.54)

1.16 (1.04, 1.30)

1.06 (0.89, 1.27)

1.12 (1.04, 1.21)

1.31 (0.91, 1.88)

1.09 (0.86, 1.38)

1.25 (0.99, 1.58)

ES (95% CI)

0.87 (0.51, 1.48)

1.08 (1.05, 1.12)

1.29 (0.83, 2.00)

1.00 (0.78, 1.28)

0.75 (0.55, 1.02)

1.15 (0.80, 1.66)

1.08 (0.93, 1.26)

100.00

0.59

9.86

1.17

%

2.15

7.46

3.14

15.00

0.77

1.80

1.84

Weight

0.37

47.53

0.53

1.70

1.07

0.77

4.25

1.09 (1.06, 1.13)

1.49 (0.98, 2.26)

1.04 (0.94, 1.15)

0.96 (0.71, 1.29)

1.24 (1.00, 1.54)

1.16 (1.04, 1.30)

1.06 (0.89, 1.27)

1.12 (1.04, 1.21)

1.31 (0.91, 1.88)

1.09 (0.86, 1.38)

1.25 (0.99, 1.58)

ES (95% CI)

0.87 (0.51, 1.48)

1.08 (1.05, 1.12)

1.29 (0.83, 2.00)

1.00 (0.78, 1.28)

0.75 (0.55, 1.02)

1.15 (0.80, 1.66)

1.08 (0.93, 1.26)

100.00

0.59

9.86

1.17

%

2.15

7.46

3.14

15.00

0.77

1.80

1.84

Weight

0.37

47.53

0.53

1.70

1.07

0.77

4.25

1.443 1 2.26

0.1

.2.3

s.e

. of lo

g(S

tudy R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


BMI per 5kg/m2: Rectal cancer inc, men



Rapp_2005

Studyauthor_year

MacInnis_2006

Lin_2004

Pischon_2006

Gaard_1997

Otani_2005

Adams_2007

Thune_1996

Kuriyama_2005

Lukanova_2006

Wei_2004_w

Terry_2002

Engeland_2005

Shimizu_2003

1.02 (0.99, 1.05)

0.90 (0.74, 1.09)

ES (95% CI)

0.98 (0.79, 1.21)

1.20 (0.87, 1.65)

1.04 (0.89, 1.22)

0.76 (0.52, 1.12)

1.13 (0.79, 1.61)

1.08 (0.96, 1.22)

0.98 (0.71, 1.35)

1.12 (0.67, 1.87)

1.19 (0.71, 1.98)

1.22 (1.02, 1.46)

1.09 (0.88, 1.36)

1.01 (0.98, 1.04)

0.85 (0.39, 1.85)

100.00

1.92

%

Weight

1.59

0.70

2.90

0.49

0.57

5.02

0.70

0.27

0.28

2.24

1.52

81.67

0.12

1.02 (0.99, 1.05)

0.90 (0.74, 1.09)

ES (95% CI)

0.98 (0.79, 1.21)

1.20 (0.87, 1.65)

1.04 (0.89, 1.22)

0.76 (0.52, 1.12)

1.13 (0.79, 1.61)

1.08 (0.96, 1.22)

0.98 (0.71, 1.35)

1.12 (0.67, 1.87)

1.19 (0.71, 1.98)

1.22 (1.02, 1.46)

1.09 (0.88, 1.36)

1.01 (0.98, 1.04)

0.85 (0.39, 1.85)

100.00

1.92

%

Weight

1.59

0.70

2.90

0.49

0.57

5.02

0.70

0.27

0.28

2.24

1.52

81.67

0.12

1.391 1 2.56

0.1

.2.3

.4s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Rectal cancer inc, women



Arano_2011

Oh_2005

N'Kontchou_2006

Chen_2008

Rapp_2005

Studyauthor_year

Batty_2005

Inoue_2009

Ohki_2008

Joshi_2008

Jee_2008

Veldt_2008

Ioannou_2007

N'Kontchou_2010

Batty_2009

Samanic_2006

Hart_2010

Kuriyama_2005

Borena_2011

Calle_2003

1.37 (1.23, 1.53)

1.23 (0.91, 1.66)

1.11 (1.02, 1.21)

2.17 (1.75, 2.69)

1.25 (0.99, 1.58)

1.40 (0.91, 2.15)

ES (95% CI)

1.28 (0.71, 2.31)

2.23 (1.14, 4.36)

1.76 (1.32, 2.35)

0.99 (0.87, 1.12)

1.12 (1.05, 1.19)

0.73 (0.37, 1.44)

2.36 (1.55, 3.60)

1.61 (1.23, 2.11)

1.18 (0.92, 1.52)

1.84 (1.46, 2.32)

1.48 (1.01, 2.17)

0.99 (0.65, 1.51)

1.47 (0.61, 3.53)

1.36 (1.24, 1.50)

100.00

5.42

8.51

6.69

6.43

3.80

Weight

2.52

2.09

5.56

8.03

8.72

2.05

3.87

5.86

6.13

6.43

4.29

3.85

1.35

8.40

%

1.37 (1.23, 1.53)

1.23 (0.91, 1.66)

1.11 (1.02, 1.21)

2.17 (1.75, 2.69)

1.25 (0.99, 1.58)

1.40 (0.91, 2.15)

ES (95% CI)

1.28 (0.71, 2.31)

2.23 (1.14, 4.36)

1.76 (1.32, 2.35)

0.99 (0.87, 1.12)

1.12 (1.05, 1.19)

0.73 (0.37, 1.44)

2.36 (1.55, 3.60)

1.61 (1.23, 2.11)

1.18 (0.92, 1.52)

1.84 (1.46, 2.32)

1.48 (1.01, 2.17)

0.99 (0.65, 1.51)

1.47 (0.61, 3.53)

1.36 (1.24, 1.50)

100.00

5.42

8.51

6.69

6.43

3.80

Weight

2.52

2.09

5.56

8.03

8.72

2.05

3.87

5.86

6.13

6.43

4.29

3.85

1.35

8.40

%

1.23 1 4.36

0.1

.2.3

.4.5

s.e

. o

f lo

g(S

tud

y R

R)



BMI per 5kg/m2: Liver cancer inc



Engeland_2005

Engeland_2005

Schlesinger_1013

Studyauthor_year

Ishiguro_2008

Kuriyama_2005

Jee_2008

Samanic_2006

Ishiguro_2008

Kuriyama_2005

Jee_2008

1.56 (1.34, 1.81)

1.88 (1.60, 2.21)

1.38 (1.01, 1.89)

1.26 (0.87, 1.83)

ES (95% CI)

1.19 (0.69, 2.05)

4.45 (1.39, 14.24)

1.65 (1.11, 2.45)

1.40 (0.73, 2.69)

1.62 (0.93, 2.83)

0.46 (0.05, 4.08)

1.44 (0.98, 2.12)

100.00

29.57

15.43

12.19

%

Weight

6.71

1.65

11.20

4.84

6.39

0.48

11.54

1.56 (1.34, 1.81)

1.88 (1.60, 2.21)

1.38 (1.01, 1.89)

1.26 (0.87, 1.83)

ES (95% CI)

1.19 (0.69, 2.05)

4.45 (1.39, 14.24)

1.65 (1.11, 2.45)

1.40 (0.73, 2.69)

1.62 (0.93, 2.83)

0.46 (0.05, 4.08)

1.44 (0.98, 2.12)

100.00

29.57

15.43

12.19

%

Weight

6.71

1.65

11.20

4.84

6.39

0.48

11.54

1.0519 1 19.3

0.5

1s.e

. o

f lo

g(S

tud

y R

R)

-2 -1 0 1 2 3log(Study RR)


BMI per 5kg/m2: Biliary tract cancer inc overall



Studyauthor_year

Stolzenberg-salomon_2008

Patel_2005

Johansen_2009

Kuriyama_2005

Verhage_2007

Meinhold_2009

Isaksson_2002

Luo_2007

Michaud_2001_HPFS

Sinner_2005

Samanic_2006

Rapp_2005

Nothlings_2007

Berrington de Gonzales_2006

Jee_2008

Luo_2008

Shibata_1994

Michaud_2001_NHS

Stevens_2009

Larsson_2005_SMC

Andreotti_2010

Larsson_2005_COSM

1.10 (1.06, 1.14)

ES (95% CI)

1.05 (0.98, 1.13)

1.37 (1.17, 1.61)

1.22 (0.99, 1.50)

1.06 (0.66, 1.71)

1.23 (1.05, 1.45)

1.03 (0.89, 1.20)

1.04 (0.78, 1.39)

0.96 (0.68, 1.35)

1.28 (0.98, 1.67)

1.05 (0.91, 1.22)

1.02 (0.90, 1.15)

1.19 (0.99, 1.43)

0.95 (0.85, 1.07)

1.09 (0.95, 1.25)

1.15 (1.08, 1.23)

1.04 (0.90, 1.21)

1.21 (0.73, 2.00)

1.16 (0.98, 1.37)

1.09 (1.03, 1.16)

1.22 (0.89, 1.67)

1.12 (0.86, 1.46)

1.34 (0.94, 1.91)

100.00

Weight

12.01

4.24

2.79

0.56

4.16

4.71

1.46

%

1.08

1.77

4.78

6.34

3.35

6.93

5.62

13.00

4.78

0.52

3.92

13.94

1.27

1.73

1.03

1.10 (1.06, 1.14)

ES (95% CI)

1.05 (0.98, 1.13)

1.37 (1.17, 1.61)

1.22 (0.99, 1.50)

1.06 (0.66, 1.71)

1.23 (1.05, 1.45)

1.03 (0.89, 1.20)

1.04 (0.78, 1.39)

0.96 (0.68, 1.35)

1.28 (0.98, 1.67)

1.05 (0.91, 1.22)

1.02 (0.90, 1.15)

1.19 (0.99, 1.43)

0.95 (0.85, 1.07)

1.09 (0.95, 1.25)

1.15 (1.08, 1.23)

1.04 (0.90, 1.21)

1.21 (0.73, 2.00)

1.16 (0.98, 1.37)

1.09 (1.03, 1.16)

1.22 (0.89, 1.67)

1.12 (0.86, 1.46)

1.34 (0.94, 1.91)

100.00

Weight

12.01

4.24

2.79

0.56

4.16

4.71

1.46

%

1.08

1.77

4.78

6.34

3.35

6.93

5.62

13.00

4.78

0.52

3.92

13.94

1.27

1.73

1.03

1.501 1 2

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


BMI per 5kg/m2: Pancreatic cancer inc



Larsson_2005_COSM

Studyauthor_year


Larsson_2005_SMC

Luo_2008


1.11 (1.05, 1.18)

1.32 (1.00, 1.74)

ES (95% CI)

1.13 (1.01, 1.26)

1.15 (0.86, 1.54)

1.08 (0.98, 1.19)

1.11 (1.00, 1.24)

100.00

4.22

Weight

26.46

3.81

37.53

27.97

%

1.11 (1.05, 1.18)

1.32 (1.00, 1.74)

ES (95% CI)

1.13 (1.01, 1.26)

1.15 (0.86, 1.54)

1.08 (0.98, 1.19)

1.11 (1.00, 1.24)

100.00

4.22

Weight

26.46

3.81

37.53

27.97

%

1.574 1 1.74

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4log(Study RR)


WC per 10 cm: Pancreatic cancer inc



Studyauthor_year

Patel_2005

Isaksson_2002

1.05 (0.87, 1.26)

ES (95% CI)

0.97 (0.84, 1.12)

1.18 (0.94, 1.49)

100.00

Weight

%

60.97

39.03

1.05 (0.87, 1.26)

ES (95% CI)

0.97 (0.84, 1.12)

1.18 (0.94, 1.49)

100.00

Weight

%

60.97

39.03

1.673 1 1.49

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.2 -.1 0 .1 .2 .3log(Study RR)


WG per 5kg: Pancreatic cancer inc




Luo_2008

Studyauthor_year

Sinner_2005


1.20 (1.09, 1.31)

1.24 (1.04, 1.48)

1.32 (1.12, 1.56)

ES (95% CI)

1.07 (0.90, 1.27)

1.16 (0.97, 1.39)

100.00

24.19

27.17

Weight

25.30

23.33

%

1.20 (1.09, 1.31)

1.24 (1.04, 1.48)

1.32 (1.12, 1.56)

ES (95% CI)

1.07 (0.90, 1.27)

1.16 (0.97, 1.39)

100.00

24.19

27.17

Weight

25.30

23.33

%

1.642 1 1.56

0.0

2.0

4.0

6.0

8.1

s.e

. o

f lo

g(S

tud

y R

R)

0 .1 .2 .3 .4log(Study RR)


WHR per 0.1 units: Pancreatic cancer inc



Batty_2009

Arnold_2009

Lin_2007

Gapstur_2000

Stevens_2009

Studyauthor_year

Lee_2003

Nakamura_2011

1.16 (0.99, 1.36)

1.05 (0.79, 1.40)

1.53 (1.21, 1.93)

0.79 (0.30, 2.09)

1.78 (1.03, 3.08)

1.06 (1.01, 1.11)

ES (95% CI)

1.06 (0.79, 1.42)

0.90 (0.50, 1.61)

100.00

16.11

19.70

2.55

6.89

32.63

Weight

15.91

6.20

%

1.16 (0.99, 1.36)

1.05 (0.79, 1.40)

1.53 (1.21, 1.93)

0.79 (0.30, 2.09)

1.78 (1.03, 3.08)

1.06 (1.01, 1.11)

ES (95% CI)

1.06 (0.79, 1.42)

0.90 (0.50, 1.61)

100.00

16.11

19.70

2.55

6.89

32.63

Weight

15.91

6.20

%

1.299 1 3.34

0.1

.2.3

.4.5

s.e

. o

f lo

g(S

tud

y R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Pancreatic cancer mortality



Kark_1995

Olson_2002

Samanic_2006

Oh_2005

Studyauthor_year

Chyou_1994

Rapp_2005

Tulinius_1997

Reeves_2007

Knekt_1996

Tulinius_1997

Kuriyama_2005

Kuriyama_2005

Rapp_2005

Knekt_1991

Lindgren_2003

0.77 (0.72, 0.83)

0.73 (0.53, 1.00)

0.71 (0.61, 0.83)

0.84 (0.80, 0.89)

0.83 (0.76, 0.90)

ES (95% CI)

0.84 (0.66, 1.06)

0.97 (0.73, 1.29)

0.51 (0.42, 0.62)

0.86 (0.82, 0.90)

0.69 (0.48, 0.99)

0.59 (0.49, 0.72)

0.73 (0.49, 1.09)

0.96 (0.59, 1.55)

0.90 (0.80, 1.01)

0.74 (0.58, 0.95)

0.71 (0.59, 0.85)

100.00

3.72

8.18

12.34

11.22

%

Weight

5.36

4.16

6.38

12.57

3.05

6.61

2.50

1.88

9.84

5.10

7.07

0.77 (0.72, 0.83)

0.73 (0.53, 1.00)

0.71 (0.61, 0.83)

0.84 (0.80, 0.89)

0.83 (0.76, 0.90)

ES (95% CI)

0.84 (0.66, 1.06)

0.97 (0.73, 1.29)

0.51 (0.42, 0.62)

0.86 (0.82, 0.90)

0.69 (0.48, 0.99)

0.59 (0.49, 0.72)

0.73 (0.49, 1.09)

0.96 (0.59, 1.55)

0.90 (0.80, 1.01)

0.74 (0.58, 0.95)

0.71 (0.59, 0.85)

100.00

3.72

8.18

12.34

11.22

%

Weight

5.36

4.16

6.38

12.57

3.05

6.61

2.50

1.88

9.84

5.10

7.07

1.416 1 2.4

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.6 -.4 -.2 0 .2log(Study RR)


BMI per 5kg/m2: Lung cancer inc, overall



Oh_2005

Knekt_1996

Samanic_2006

Lindgren_2003

Chyou_1994

Kuriyama_2005

Studyauthor_year

Tulinius_1997

Kark_1995

Knekt_1991

Rapp_2005

0.79 (0.73, 0.85)

0.83 (0.76, 0.90)

0.69 (0.48, 0.99)

0.84 (0.80, 0.89)

0.71 (0.59, 0.85)

0.84 (0.66, 1.06)

0.73 (0.49, 1.09)

ES (95% CI)

0.59 (0.49, 0.72)

0.73 (0.53, 1.00)

0.74 (0.58, 0.95)

0.90 (0.80, 1.01)

100.00

18.88

3.65

21.98

9.87

6.98

2.94

Weight

9.05

4.56

6.58

15.50

%

0.79 (0.73, 0.85)

0.83 (0.76, 0.90)

0.69 (0.48, 0.99)

0.84 (0.80, 0.89)

0.71 (0.59, 0.85)

0.84 (0.66, 1.06)

0.73 (0.49, 1.09)

ES (95% CI)

0.59 (0.49, 0.72)

0.73 (0.53, 1.00)

0.74 (0.58, 0.95)

0.90 (0.80, 1.01)

100.00

18.88

3.65

21.98

9.87

6.98

2.94

Weight

9.05

4.56

6.58

15.50

%

1.483 1 2.07

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.6 -.4 -.2 0 .2log(Study RR)


BMI per 5kg/m2: Lung cancer inc, men



Tulinius_1997

Rapp_2005

Reeves_2007

Kuriyama_2005

Studyauthor_year

Olson_2002

0.76 (0.61, 0.94)

0.51 (0.42, 0.62)

0.97 (0.73, 1.29)

0.86 (0.82, 0.90)

0.96 (0.59, 1.55)

ES (95% CI)

0.71 (0.61, 0.83)

100.00

21.38

17.88

26.11

11.38

Weight

23.26

%

0.76 (0.61, 0.94)

0.51 (0.42, 0.62)

0.97 (0.73, 1.29)

0.86 (0.82, 0.90)

0.96 (0.59, 1.55)

ES (95% CI)

0.71 (0.61, 0.83)

100.00

21.38

17.88

26.11

11.38

Weight

23.26

%

1.416 1 2.4

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.6 -.4 -.2 0 .2 .4log(Study RR)


BMI per 5kg/m2: Lung cancer inc, women



Studyauthor_year

Olson_2002

Reeves_2007

Kark_1995

Samanic_2006

0.77 (0.69, 0.86)

ES (95% CI)

0.76 (0.64, 0.91)

0.85 (0.80, 0.91)

0.51 (0.39, 0.67)

0.82 (0.77, 0.87)

100.00

Weight

19.84

%

33.89

12.00

34.27

0.77 (0.69, 0.86)

ES (95% CI)

0.76 (0.64, 0.91)

0.85 (0.80, 0.91)

0.51 (0.39, 0.67)

0.82 (0.77, 0.87)

100.00

Weight

19.84

%

33.89

12.00

34.27

1.389 1 2.57

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.6 -.4 -.2 0 .2log(Study RR)


BMI per 5kg/m2: Lung cancer inc, smokers



Olson_2002

Studyauthor_year

Samanic_2006

Reeves_2007

Kark_1995

0.89 (0.72, 1.09)

0.67 (0.50, 0.89)

ES (95% CI)

1.11 (0.86, 1.44)

0.91 (0.77, 1.07)

0.87 (0.46, 1.63)

100.00

25.39

Weight

27.91

37.71

8.99

%

0.89 (0.72, 1.09)

0.67 (0.50, 0.89)

ES (95% CI)

1.11 (0.86, 1.44)

0.91 (0.77, 1.07)

0.87 (0.46, 1.63)

100.00

25.39

Weight

27.91

37.71

8.99

%

1.464 1 2.16

0.1

.2.3

s.e

. o

f lo

g(S

tud

y R

R)

-1 -.5 0 .5log(Study RR)


BMI per 5kg/m2: Lung cancer inc, non-smokers



Samanic_2006

Reeves_2007

Rapp_2005

Rapp_2005

Freedman_2003

Oh_2005

Studyauthor_year

Thune_1993

Lukanova_2006

Lukanova_2006

Thune_1993

Freedman_2003

1.07 (0.97, 1.17)

1.21 (1.10, 1.33)

0.97 (0.93, 1.02)

0.90 (0.69, 1.17)

1.03 (0.81, 1.31)

0.97 (0.58, 1.62)

1.95 (1.17, 3.25)

ES (95% CI)

0.93 (0.87, 0.99)

1.35 (0.86, 2.12)

1.40 (0.85, 2.30)

1.16 (1.07, 1.25)

0.97 (0.79, 1.20)

100.00

15.06

16.87

7.23

%

7.91

2.74

2.76

Weight

16.24

3.39

2.89

15.72

9.19

1.07 (0.97, 1.17)

1.21 (1.10, 1.33)

0.97 (0.93, 1.02)

0.90 (0.69, 1.17)

1.03 (0.81, 1.31)

0.97 (0.58, 1.62)

1.95 (1.17, 3.25)

ES (95% CI)

0.93 (0.87, 0.99)

1.35 (0.86, 2.12)

1.40 (0.85, 2.30)

1.16 (1.07, 1.25)

0.97 (0.79, 1.20)

100.00

15.06

16.87

7.23

%

7.91

2.74

2.76

Weight

16.24

3.39

2.89

15.72

9.19

1.308 1 3.25

0.0

5.1

.15

.2.2

5s.e

. of lo

g(S

tudy R

R)



BMI per 5kg/m2: Melanoma inc, overall



Studyauthor_year

Freedman_2003

Oh_2005

Lukanova_2006

Rapp_2005

Thune_1993

Samanic_2006

1.17 (1.05, 1.30)

ES (95% CI)

0.97 (0.58, 1.62)

1.95 (1.17, 3.25)

1.40 (0.85, 2.30)

0.90 (0.69, 1.17)

1.16 (1.07, 1.25)

1.21 (1.10, 1.33)

100.00

Weight

4.03

4.06

4.26

12.39

39.08

%

36.18

1.17 (1.05, 1.30)

ES (95% CI)

0.97 (0.58, 1.62)

1.95 (1.17, 3.25)

1.40 (0.85, 2.30)

0.90 (0.69, 1.17)

1.16 (1.07, 1.25)

1.21 (1.10, 1.33)

100.00

Weight

4.03

4.06

4.26

12.39

39.08

%

36.18

1.308 1 3.25

0.0

5.1

.15

.2.2

5s.e

. of lo

g(S

tudy R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


BMI per 5kg/m2: Melanoma inc, men



Rapp_2005

Lukanova_2006

Thune_1993

Reeves_2007

Studyauthor_year

Freedman_2003

0.96 (0.93, 1.00)

1.03 (0.81, 1.31)

1.35 (0.86, 2.12)

0.93 (0.87, 0.99)

0.97 (0.93, 1.02)

ES (95% CI)

0.97 (0.79, 1.20)

100.00

2.29

0.67

32.67

61.32

Weight

3.06

%

0.96 (0.93, 1.00)

1.03 (0.81, 1.31)

1.35 (0.86, 2.12)

0.93 (0.87, 0.99)

0.97 (0.93, 1.02)

ES (95% CI)

0.97 (0.79, 1.20)

100.00

2.29

0.67

32.67

61.32

Weight

3.06

%

1.472 1 2.12

0.0

5.1

.15

.2.2

5s.e

. of lo

g(S

tudy R

R)

-.6 -.4 -.2 0 .2 .4log(Study RR)


BMI per 5kg/m2: Melanoma inc, women



Lukanova_2006

Yong_1996

Sonnenschein_1999

Manjer_2001

Vatten_1992

De Stavola_1993

Weiderpass_2004

Iwasaki_2007

Galanis_1998

Wu_2006

Lahmann_2004

Palmer_2007

Michels_2006

Studyauthor_year

Li_2006

Silvera_2006

Reeves_2007

Kaaks_1998

Huang_1997

Tehard_2006

Kuriyama_2005

0.92 (0.88, 0.96)

0.65 (0.44, 0.96)

0.94 (0.78, 1.14)

0.89 (0.67, 1.18)

1.03 (0.76, 1.39)

0.82 (0.72, 0.94)

1.03 (0.73, 1.45)

0.81 (0.67, 0.97)

1.20 (0.97, 1.49)

1.24 (0.89, 1.72)

1.33 (0.90, 1.96)

0.90 (0.81, 0.99)

0.91 (0.84, 0.99)

0.91 (0.86, 0.97)

ES (95% CI)

1.03 (0.80, 1.32)

1.04 (0.90, 1.20)

0.93 (0.86, 1.00)

0.97 (0.75, 1.25)

0.84 (0.77, 0.92)

0.78 (0.56, 1.08)

0.86 (0.42, 1.77)

100.00

1.30

4.33

2.26

%

2.01

6.99

1.60

4.50

3.58

1.72

1.27

9.53

11.11

13.34

Weight

2.83

6.60

11.77

2.69

10.45

1.73

0.39

0.92 (0.88, 0.96)

0.65 (0.44, 0.96)

0.94 (0.78, 1.14)

0.89 (0.67, 1.18)

1.03 (0.76, 1.39)

0.82 (0.72, 0.94)

1.03 (0.73, 1.45)

0.81 (0.67, 0.97)

1.20 (0.97, 1.49)

1.24 (0.89, 1.72)

1.33 (0.90, 1.96)

0.90 (0.81, 0.99)

0.91 (0.84, 0.99)

0.91 (0.86, 0.97)

ES (95% CI)

1.03 (0.80, 1.32)

1.04 (0.90, 1.20)

0.93 (0.86, 1.00)

0.97 (0.75, 1.25)

0.84 (0.77, 0.92)

0.78 (0.56, 1.08)

0.86 (0.42, 1.77)

100.00

1.30

4.33

2.26

%

2.01

6.99

1.60

4.50

3.58

1.72

1.27

9.53

11.11

13.34

Weight

2.83

6.60

11.77

2.69

10.45

1.73

0.39

1.418 1 2.39

0.1

.2.3

.4s.e

. of lo

g(S

tudy R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Breast cancer inc, premenopausal



Lahmann_2005

Palmer_2007

Michels_2012

Studyauthor_year

0.99 (0.95, 1.03)

0.99 (0.89, 1.10)

1.02 (0.97, 1.08)

0.96 (0.92, 1.00)

ES (95% CI)

100.00

%

14.50

36.92

48.57

Weight

0.99 (0.95, 1.03)

0.99 (0.89, 1.10)

1.02 (0.97, 1.08)

0.96 (0.92, 1.00)

ES (95% CI)

100.00

%

14.50

36.92

48.57

Weight

1.895 1 1.12

0.0

1.0

2.0

3.0

4.0

5s.e

. of lo

g(S

tudy R

R)

-.1 -.05 0 .05 .1log(Study RR)


WG per 5kg: Breast cancer inc, premenopausal



Tehard_2006

Studyauthor_year

Lahman_2004

Palmer_2007

1.02 (0.97, 1.07)

0.96 (0.81, 1.13)

ES (95% CI)

1.01 (0.93, 1.10)

1.03 (0.97, 1.10)

100.00

8.37

Weight

32.94

58.69

%

1.02 (0.97, 1.07)

0.96 (0.81, 1.13)

ES (95% CI)

1.01 (0.93, 1.10)

1.03 (0.97, 1.10)

100.00

8.37

Weight

32.94

58.69

%

1.813 1 1.23

0.0

2.0

4.0

6.0

8s.e

. of lo

g(S

tudy R

R)

-.2 -.1 0 .1 .2log(Study RR)


WHR per 0.1 units: Breast cancer inc, premenopausal



Mellemkjaer_2006

Tehard_2006

Lahmann_2003

Palmer_2007

Manjer_2001

Krebs_2006

Kuriyama_2005

Studyauthor_year

Wu_2006

Kaaks_1998

Suzuki_2006

Lukanova_2006

Sellers_2002

Huang_1997

Li_2006

MacInnis_2004

Barrett-connor_1993

De Stavola_1993

Sonnenschein_1999

Galanis_1998

Chang_2006

Yong_1996

Lundqvist_2007

Morimoto_2002

Silvera_2006

Reeves_2007

Lahmann_2004

Iwasaki_2007

Mills_1989

Feigelson_2004

1.13 (1.09, 1.17)

1.02 (0.93, 1.12)

1.13 (0.97, 1.31)

1.22 (1.02, 1.46)

0.95 (0.86, 1.04)

0.93 (0.75, 1.15)

1.15 (0.99, 1.34)

1.65 (1.12, 2.43)

ES (95% CI)

1.16 (0.66, 2.05)

1.03 (0.79, 1.34)

1.12 (1.04, 1.21)

1.02 (0.89, 1.16)

1.30 (1.21, 1.39)

1.05 (0.97, 1.13)

1.55 (1.20, 2.00)

1.14 (1.02, 1.27)

1.37 (0.75, 2.49)

0.97 (0.70, 1.34)

1.51 (1.19, 1.92)

1.23 (1.03, 1.47)

1.09 (1.00, 1.19)

1.09 (1.00, 1.18)

1.16 (1.05, 1.28)

1.12 (0.84, 1.49)

1.13 (0.98, 1.30)

1.18 (1.15, 1.22)

1.05 (0.86, 1.28)

1.17 (0.96, 1.43)

1.31 (1.04, 1.65)

1.08 (0.97, 1.20)

100.00

5.25

3.47

2.81

5.17

2.22

3.44

0.86

Weight

0.41

1.65

5.87

3.95

%

6.10

5.82

1.70

4.67

0.38

1.18

1.88

2.78

5.46

5.64

5.03

1.42

3.81

7.34

2.46

2.45

1.99

4.78

1.13 (1.09, 1.17)

1.02 (0.93, 1.12)

1.13 (0.97, 1.31)

1.22 (1.02, 1.46)

0.95 (0.86, 1.04)

0.93 (0.75, 1.15)

1.15 (0.99, 1.34)

1.65 (1.12, 2.43)

ES (95% CI)

1.16 (0.66, 2.05)

1.03 (0.79, 1.34)

1.12 (1.04, 1.21)

1.02 (0.89, 1.16)

1.30 (1.21, 1.39)

1.05 (0.97, 1.13)

1.55 (1.20, 2.00)

1.14 (1.02, 1.27)

1.37 (0.75, 2.49)

0.97 (0.70, 1.34)

1.51 (1.19, 1.92)

1.23 (1.03, 1.47)

1.09 (1.00, 1.19)

1.09 (1.00, 1.18)

1.16 (1.05, 1.28)

1.12 (0.84, 1.49)

1.13 (0.98, 1.30)

1.18 (1.15, 1.22)

1.05 (0.86, 1.28)

1.17 (0.96, 1.43)

1.31 (1.04, 1.65)

1.08 (0.97, 1.20)

100.00

5.25

3.47

2.81

5.17

2.22

3.44

0.86

Weight

0.41

1.65

5.87

3.95

%

6.10

5.82

1.70

4.67

0.38

1.18

1.88

2.78

5.46

5.64

5.03

1.42

3.81

7.34

2.46

2.45

1.99

4.78

1.401 1 2.49

0.1

.2.3

s.e

. of lo

g(S

tudy R

R)



BMI per 5kg/m2: Breast cancer inc, postmenopausal



Kawai_2010

Palmer_2007

Alsaker_2013

Eliassen_2006

Feigelson_2004

Studyauthor_year

Ahn_2007

Lahmann_2005

1.11 (1.09, 1.13)

1.26 (1.00, 1.59)

1.04 (0.95, 1.14)

1.10 (1.03, 1.18)

1.14 (1.11, 1.18)

1.11 (1.07, 1.15)

ES (95% CI)

1.09 (1.05, 1.13)

1.09 (1.03, 1.16)

100.00

0.78

4.40

8.27

29.63

23.60

Weight

22.98

10.34

%

1.11 (1.09, 1.13)

1.26 (1.00, 1.59)

1.04 (0.95, 1.14)

1.10 (1.03, 1.18)

1.14 (1.11, 1.18)

1.11 (1.07, 1.15)

ES (95% CI)

1.09 (1.05, 1.13)

1.09 (1.03, 1.16)

100.00

0.78

4.40

8.27

29.63

23.60

Weight

22.98

10.34

%

1.629 1 1.59

0.0

5.1

.15

s.e

. of lo

g(S

tudy R

R)

-.1 0 .1 .2 .3log(Study RR)


WG per 5kg: Breast cancer inc, postmenopausal, HRT -



Ahn_2007

Lahmann_2005

Studyauthor_year

Eliassen_2006

Feigelson_2004

1.01 (0.99, 1.02)

1.02 (0.99, 1.06)

0.99 (0.92, 1.06)

ES (95% CI)

1.01 (0.99, 1.04)

0.98 (0.94, 1.02)

100.00

26.20

6.09

Weight

49.38

18.33

%

1.01 (0.99, 1.02)

1.02 (0.99, 1.06)

0.99 (0.92, 1.06)

ES (95% CI)

1.01 (0.99, 1.04)

0.98 (0.94, 1.02)

100.00

26.20

6.09

Weight

49.38

18.33

%

1.922 1 1.08

0.0

1.0

2.0

3.0

4s.e

. of lo

g(S

tudy R

R)

-.1 -.05 0 .05 .1log(Study RR)


WG per 5kg: Breast cancer inc, postmenopausal, HRT +



Studyauthor_year

Gapstur_1993

Chang_2007

Jonsson_2003

Schouten_2004

Canchola_2010

Han_2014

Yang_2012

Dougan_2015

Park_2010

1.45 (1.28, 1.64)

ES (95% CI)

1.33 (1.02, 1.73)

1.23 (1.12, 1.36)

1.32 (0.85, 2.05)

1.40 (1.11, 1.77)

1.24 (1.08, 1.43)

1.69 (1.40, 2.04)

1.95 (1.67, 2.27)

1.42 (1.22, 1.65)

1.56 (1.24, 1.96)

100.00

Weight

9.14

14.61

5.16

10.05

%

13.27

11.71

12.83

12.91

10.33

1.45 (1.28, 1.64)

ES (95% CI)

1.33 (1.02, 1.73)

1.23 (1.12, 1.36)

1.32 (0.85, 2.05)

1.40 (1.11, 1.77)

1.24 (1.08, 1.43)

1.69 (1.40, 2.04)

1.95 (1.67, 2.27)

1.42 (1.22, 1.65)

1.56 (1.24, 1.96)

100.00

Weight

9.14

14.61

5.16

10.05

%

13.27

11.71

12.83

12.91

10.33

1.44 1 2.27

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6 .8log(Study RR)


BMI iya, per 5kgm2: Endometrial cancer inc



Wu_2014

Reeves_2007

Reeves_2011

de Waard_1996

Studyauthor_year

Lacey_2005

McCullough_2008

Folsom_2003

Song_2008

Silvera_2005

Tornberg_1994

Lundqvist_2007

Park_2010

Weiderpass_2014

Epstein_2009

Rapp_2005

Lukanova_2006

Tulinius_1997

Chang_2007

Kuriyama_2005

Dougan_2015

Lindemann_2009

Conroy_2009

Bjorge_2007

Schouten_2004

Canchola_2010

Friedenreich_2007

Alford_2015

Bhaskaran_2014

1.54 (1.47, 1.61)

1.03 (0.55, 1.92)

1.70 (1.62, 1.78)

1.25 (1.15, 1.36)

1.70 (1.22, 2.36)

ES (95% CI)

1.20 (1.04, 1.39)

1.69 (1.47, 1.94)

1.77 (1.59, 1.97)

1.84 (1.38, 2.45)

1.75 (1.56, 1.96)

1.70 (1.42, 2.04)

1.79 (1.61, 1.99)

1.58 (1.42, 1.75)

1.42 (1.22, 1.66)

1.78 (1.44, 2.21)

1.38 (1.23, 1.55)

1.80 (1.33, 2.43)

1.31 (1.07, 1.61)

1.55 (1.44, 1.67)

1.63 (0.94, 2.82)

1.40 (1.32, 1.48)

1.67 (1.34, 2.09)

1.45 (1.27, 1.66)

1.65 (1.60, 1.71)

1.84 (1.47, 2.30)

1.30 (1.19, 1.42)

1.34 (1.22, 1.47)

1.53 (1.16, 2.02)

1.62 (1.56, 1.69)

100.00

0.49

5.54

4.85

1.47

Weight

3.70

3.83

4.46

1.77

4.31

3.06

4.53

4.51

3.54

2.58

4.28

1.66

2.71

5.05

0.62

5.39

2.45

3.92

5.71

2.48

4.83

%

4.74

1.87

5.64

1.54 (1.47, 1.61)

1.03 (0.55, 1.92)

1.70 (1.62, 1.78)

1.25 (1.15, 1.36)

1.70 (1.22, 2.36)

ES (95% CI)

1.20 (1.04, 1.39)

1.69 (1.47, 1.94)

1.77 (1.59, 1.97)

1.84 (1.38, 2.45)

1.75 (1.56, 1.96)

1.70 (1.42, 2.04)

1.79 (1.61, 1.99)

1.58 (1.42, 1.75)

1.42 (1.22, 1.66)

1.78 (1.44, 2.21)

1.38 (1.23, 1.55)

1.80 (1.33, 2.43)

1.31 (1.07, 1.61)

1.55 (1.44, 1.67)

1.63 (0.94, 2.82)

1.40 (1.32, 1.48)

1.67 (1.34, 2.09)

1.45 (1.27, 1.66)

1.65 (1.60, 1.71)

1.84 (1.47, 2.30)

1.30 (1.19, 1.42)

1.34 (1.22, 1.47)

1.53 (1.16, 2.02)

1.62 (1.56, 1.69)

100.00

0.49

5.54

4.85

1.47

Weight

3.70

3.83

4.46

1.77

4.31

3.06

4.53

4.51

3.54

2.58

4.28

1.66

2.71

5.05

0.62

5.39

2.45

3.92

5.71

2.48

4.83

%

4.74

1.87

5.64

1.354 1 2.82

0.1

.2.3

s.e

. o

f lo

g(S

tud

y R

R)



BMI per 5kg/m2: Endometrial cancer inc



Friedenreich_2007

Conroy_2009

Studyauthor_year

1.29 (1.19, 1.41)

1.32 (1.20, 1.45)

1.19 (0.98, 1.45)

ES (95% CI)

100.00

81.08

%

18.92

Weight

1.29 (1.19, 1.41)

1.32 (1.20, 1.45)

1.19 (0.98, 1.45)

ES (95% CI)

100.00

81.08

%

18.92

Weight

1.689 1 1.45

0.0

2.0

4.0

6.0

8.1

s.e

. o

f lo

g(S

tud

y R

R)

.1 .2 .3 .4 .5log(Study RR)


HC per 10cm: Endometrial cancer inc



Park_2010

Chang_2007

Jonsson_2003

Han_2014

Canchola_2010

Friedenreich_2007

Studyauthor_year

Dougan_2015

1.16 (1.12, 1.20)

1.24 (1.16, 1.33)

1.20 (1.14, 1.27)

1.15 (0.99, 1.33)

1.13 (1.04, 1.23)

1.09 (1.03, 1.15)

1.13 (1.07, 1.20)

ES (95% CI)

1.17 (1.12, 1.22)

100.00

13.57

17.32

4.37

10.63

17.00

16.22

Weight

20.89

%

1.16 (1.12, 1.20)

1.24 (1.16, 1.33)

1.20 (1.14, 1.27)

1.15 (0.99, 1.33)

1.13 (1.04, 1.23)

1.09 (1.03, 1.15)

1.13 (1.07, 1.20)

ES (95% CI)

1.17 (1.12, 1.22)

100.00

13.57

17.32

4.37

10.63

17.00

16.22

Weight

20.89

%

1.75 1 1.33

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

0 .1 .2 .3log(Study RR)


WG per 5kg: Endometrial cancer inc



Conroy_2009

Friedenreich_2007

Folsom_2000

Canchola_2010

Studyauthor_year

1.27 (1.17, 1.39)

1.14 (0.98, 1.32)

1.28 (1.19, 1.37)

1.44 (1.32, 1.58)

1.21 (1.10, 1.33)

ES (95% CI)

100.00

17.97

29.76

26.49

%

25.78

Weight

1.27 (1.17, 1.39)

1.14 (0.98, 1.32)

1.28 (1.19, 1.37)

1.44 (1.32, 1.58)

1.21 (1.10, 1.33)

ES (95% CI)

100.00

17.97

29.76

26.49

%

25.78

Weight

1.634 1 1.58

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

.1 .2 .3 .4log(Study RR)


WC per 10 cm: Endometrial cancer inc



Park_2010

Terry_1999

Tulinius_1997

Friedenreich_2007

Schouten_2004

Studyauthor_year

de Waard_1996

Weiderpass_2014

1.17 (1.13, 1.22)

1.20 (1.15, 1.25)

1.21 (1.10, 1.33)

1.12 (1.04, 1.20)

1.11 (1.08, 1.15)

1.25 (1.16, 1.35)

ES (95% CI)

1.19 (1.10, 1.28)

1.15 (0.97, 1.36)

100.00

20.60

10.58

%

14.28

22.74

13.51

Weight

13.52

4.76

1.17 (1.13, 1.22)

1.20 (1.15, 1.25)

1.21 (1.10, 1.33)

1.12 (1.04, 1.20)

1.11 (1.08, 1.15)

1.25 (1.16, 1.35)

ES (95% CI)

1.19 (1.10, 1.28)

1.15 (0.97, 1.36)

100.00

20.60

10.58

%

14.28

22.74

13.51

Weight

13.52

4.76

1.737 1 1.36

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)



Weight per 5kg: Endometrial cancer inc



Canchola_2010

Studyauthor_year

Friedenreich_2007

Folsom_2003

Conroy_2009

Reeves_2011

1.21 (1.13, 1.29)

1.14 (0.98, 1.32)

ES (95% CI)

1.17 (1.03, 1.32)

1.33 (1.18, 1.50)

1.12 (0.81, 1.55)

1.18 (1.04, 1.34)

100.00

18.48

%

Weight

26.64

26.96

3.82

24.09

1.21 (1.13, 1.29)

1.14 (0.98, 1.32)

ES (95% CI)

1.17 (1.03, 1.32)

1.33 (1.18, 1.50)

1.12 (0.81, 1.55)

1.18 (1.04, 1.34)

100.00

18.48

%

Weight

26.64

26.96

3.82

24.09

1.643 1 1.55

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


WHR per 0.1 units: Endometrial cancer inc



Studyauthor_year

Khan_2006

Reeves_2007

Calle_2003

1.46 (1.29, 1.65)

ES (95% CI)

0.64 (0.19, 2.17)

1.57 (1.33, 1.85)

1.42 (1.28, 1.57)

100.00

%

Weight

1.02

37.43

61.55

1.46 (1.29, 1.65)

ES (95% CI)

0.64 (0.19, 2.17)

1.57 (1.33, 1.85)

1.42 (1.28, 1.57)

100.00

%

Weight

1.02

37.43

61.55

1.189 1 5.29

0.2

.4.6

s.e

. o

f lo

g(S

tud

y R

R)

-1 -.5 0 .5 1 1.5log(Study RR)


BMI per 5kg/m2: Endometrial cancer mortality



Bjorge_2006

Reeves_2007

Lindemann_2008

Furberg&Thune_2003

Studyauthor_year

Friedenreich_2007

Lundqvist_2007

1.49 (1.39, 1.61)

1.53 (1.48, 1.58)

1.33 (1.10, 1.61)

1.69 (1.28, 2.23)

1.69 (1.23, 2.33)

ES (95% CI)

1.22 (0.96, 1.55)

1.54 (1.22, 1.94)

100.00

60.13

12.04

6.25

%

4.83

Weight

8.14

8.61

1.49 (1.39, 1.61)

1.53 (1.48, 1.58)

1.33 (1.10, 1.61)

1.69 (1.28, 2.23)

1.69 (1.23, 2.33)

ES (95% CI)

1.22 (0.96, 1.55)

1.54 (1.22, 1.94)

100.00

60.13

12.04

6.25

%

4.83

Weight

8.14

8.61

1.43 1 2.33

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

0 .2 .4 .6 .8log(Study RR)


BMI per 5kg/m2: Endometrial cancer inc, premenopausal



Friedenreich_2007

Reeves_2007

Lundqvist_2007

Furberg&Thune_2003

Lindemann_2008

Bjorge_2006

Studyauthor_year

1.60 (1.40, 1.83)

1.40 (1.25, 1.57)

2.00 (1.86, 2.16)

1.68 (1.37, 2.07)

1.45 (1.01, 2.09)

1.54 (1.32, 1.79)

1.51 (1.45, 1.58)

ES (95% CI)

100.00

18.62

20.26

14.45

8.52

17.01

21.13

Weight

%

1.60 (1.40, 1.83)

1.40 (1.25, 1.57)

2.00 (1.86, 2.16)

1.68 (1.37, 2.07)

1.45 (1.01, 2.09)

1.54 (1.32, 1.79)

1.51 (1.45, 1.58)

ES (95% CI)

100.00

18.62

20.26

14.45

8.52

17.01

21.13

Weight

%

1.464 1 2.16

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

0 .2 .4 .6 .8log(Study RR)


BMI per 5kg/m2: Endometrial cancer inc, postmenopausal



Chang_2007

McCullough_2008

Studyauthor_year

Friedenreich_2007

1.90 (1.56, 2.30)

2.26 (1.87, 2.73)

1.93 (1.64, 2.28)

ES (95% CI)

1.61 (1.41, 1.84)

100.00

%

30.84

33.20

Weight

35.96

1.90 (1.56, 2.30)

2.26 (1.87, 2.73)

1.93 (1.64, 2.28)

ES (95% CI)

1.61 (1.41, 1.84)

100.00

%

30.84

33.20

Weight

35.96

1.366 1 2.73

0.0

2.0

4.0

6.0

8.1

s.e

. o

f lo

g(S

tud

y R

R)

.4 .5 .6 .7 .8log(Study RR)


BMI per 5kg/m2: Endometrial cancer inc, postmenopausal HRT -



Studyauthor_year

Friedenreich_2007

Chang_2007_comb

McCullough_2008

Beral_2005_cycl

Chang_2007_estr

Beral_2005_cont

1.18 (1.07, 1.31)

ES (95% CI)

1.10 (0.88, 1.38)

1.26 (0.82, 1.93)

1.29 (0.82, 2.02)

1.25 (1.06, 1.48)

1.19 (0.93, 1.53)

1.02 (0.73, 1.42)

100.00

%

Weight

21.79

6.02

5.49

38.95

17.79

9.96

1.18 (1.07, 1.31)

ES (95% CI)

1.10 (0.88, 1.38)

1.26 (0.82, 1.93)

1.29 (0.82, 2.02)

1.25 (1.06, 1.48)

1.19 (0.93, 1.53)

1.02 (0.73, 1.42)

100.00

%

Weight

21.79

6.02

5.49

38.95

17.79

9.96

1.495 1 2.02

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.2 0 .2 .4 .6log(Study RR)


BMI per 5kg/m2: Endometrial cancer inc, postmenopausal HRT +



Canchola_2010

Chang_2007

Studyauthor_year

1.38 (1.28, 1.49)

1.46 (1.26, 1.70)

1.36 (1.25, 1.48)

ES (95% CI)

100.00

25.59

74.41

Weight

%

1.38 (1.28, 1.49)

1.46 (1.26, 1.70)

1.36 (1.25, 1.48)

ES (95% CI)

100.00

25.59

74.41

Weight

%

1.59 1 1.7

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

.2 .3 .4 .5log(Study RR)


WG per 5kg: Endometrial cancer inc, postmenopausal, HRT -



Studyauthor_year

Canchola_2010

Chang_2007

1.09 (1.02, 1.17)

ES (95% CI)

1.09 (0.97, 1.22)

1.09 (1.00, 1.18)

100.00

%

Weight

34.25

65.75

1.09 (1.02, 1.17)

ES (95% CI)

1.09 (0.97, 1.22)

1.09 (1.00, 1.18)

100.00

%

Weight

34.25

65.75

1.818 1 1.22

0.0

2.0

4.0

6s.e

. o

f lo

g(S

tud

y R

R)

-.05 0 .05 .1 .15 .2log(Study RR)


WG per 5kg: Endometrial cancer inc, postmenopausal, HRT +



McCullough_2008

Studyauthor_year

Bjorge_2006

Lindemann_2009

1.75 (1.51, 2.03)

2.02 (1.73, 2.35)

ES (95% CI)

1.58 (1.54, 1.63)

1.74 (1.50, 2.01)

100.00

28.97

Weight

41.27

%

29.77

1.75 (1.51, 2.03)

2.02 (1.73, 2.35)

ES (95% CI)

1.58 (1.54, 1.63)

1.74 (1.50, 2.01)

100.00

28.97

Weight

41.27

%

29.77

1.425 1 2.35

0.0

2.0

4.0

6.0

8s.e

. o

f lo

g(S

tud

y R

R)

.3 .4 .5 .6 .7log(Study RR)


BMI per 5kg/m2: Endometrial cancer inc, Type I



Lindemann_2009

Studyauthor_year

Bjorge_2006

McCullough_2008

1.51 (1.29, 1.78)

1.65 (1.46, 1.86)

ES (95% CI)

1.35 (1.25, 1.46)

1.65 (1.24, 2.19)

100.00

%

37.67

Weight

42.96

19.37

1.51 (1.29, 1.78)

1.65 (1.46, 1.86)

ES (95% CI)

1.35 (1.25, 1.46)

1.65 (1.24, 2.19)

100.00

%

37.67

Weight

42.96

19.37

1.456 1 2.19

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)



BMI per 5kg/m2: Endometrial cancer inc, Type II



Anderson_2004

Studyauthor_year

Baer_2008_1

Engeland_2003

Baer_2008_2

Leitzmann_2009

Schouten_2003

1.12 (1.05, 1.19)

1.10 (0.94, 1.29)

ES (95% CI)

1.06 (0.91, 1.23)

1.16 (1.04, 1.29)

1.34 (0.99, 1.81)

1.12 (0.99, 1.27)

0.85 (0.56, 1.30)

100.00

15.26

%

Weight

17.67

34.57

4.41

25.86

2.22

1.12 (1.05, 1.19)

1.10 (0.94, 1.29)

ES (95% CI)

1.06 (0.91, 1.23)

1.16 (1.04, 1.29)

1.34 (0.99, 1.81)

1.12 (0.99, 1.27)

0.85 (0.56, 1.30)

100.00

15.26

%

Weight

17.67

34.57

4.41

25.86

2.22

1.552 1 1.81

0.0

5.1

.15

.2s.e

. o

f lo

g(S

tud

y R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


BMI iya, per 5kgm2: Ovarian cancer inc



Kuriyama_2005

Studyauthor_year

Rapp_2005

Kotsopoulos_2010_1

Chionh_2010

Anderson_2004

Wu_2014

Ma_2013

Engeland_2003

Bhaskaran_2014

Lacey_2006

Kiani_2006

Lahmann_2009

Schouten_2003

Weiderpass_2012

Reeves_2007

Song_2008

Canchola_2010

Tornberg_1994

Khan_2013

Kotsopoulos_2010_2

Leitzmann_2009

Rodriguez_2002

Andreotti_2010

Lundqvist_2007

1.08 (1.04, 1.12)

0.87 (0.39, 1.94)

ES (95% CI)

1.08 (0.89, 1.32)

1.02 (0.93, 1.11)

1.22 (1.00, 1.48)

1.08 (0.93, 1.26)

1.74 (0.89, 3.41)

1.45 (1.12, 1.87)

0.97 (0.93, 1.01)

1.09 (1.04, 1.14)

1.05 (0.92, 1.19)

1.24 (0.78, 1.97)

1.13 (1.04, 1.22)

1.15 (0.92, 1.43)

1.00 (0.70, 1.42)

1.07 (1.01, 1.13)

1.22 (0.96, 1.55)

0.98 (0.56, 1.70)

0.93 (0.81, 1.07)

1.42 (0.69, 2.93)

1.17 (0.98, 1.39)

1.07 (0.96, 1.20)

1.10 (1.03, 1.17)

0.90 (0.66, 1.23)

1.20 (0.98, 1.46)

100.00

0.21

Weight

2.81

7.59

2.84

4.14

0.30

1.82

11.43

11.06

%

5.22

0.62

8.19

2.35

1.04

10.21

2.01

0.44

4.45

0.26

3.38

6.06

9.57

1.25

2.76

1.08 (1.04, 1.12)

0.87 (0.39, 1.94)

ES (95% CI)

1.08 (0.89, 1.32)

1.02 (0.93, 1.11)

1.22 (1.00, 1.48)

1.08 (0.93, 1.26)

1.74 (0.89, 3.41)

1.45 (1.12, 1.87)

0.97 (0.93, 1.01)

1.09 (1.04, 1.14)

1.05 (0.92, 1.19)

1.24 (0.78, 1.97)

1.13 (1.04, 1.22)

1.15 (0.92, 1.43)

1.00 (0.70, 1.42)

1.07 (1.01, 1.13)

1.22 (0.96, 1.55)

0.98 (0.56, 1.70)

0.93 (0.81, 1.07)

1.42 (0.69, 2.93)

1.17 (0.98, 1.39)

1.07 (0.96, 1.20)

1.10 (1.03, 1.17)

0.90 (0.66, 1.23)

1.20 (0.98, 1.46)

100.00

0.21

Weight

2.81

7.59

2.84

4.14

0.30

1.82

11.43

11.06

%

5.22

0.62

8.19

2.35

1.04

10.21

2.01

0.44

4.45

0.26

3.38

6.06

9.57

1.25

2.76

1.294 1 3.41

0.1

.2.3

.4s.e

. o

f lo

g(S

tud

y R

R)

-1 -.5 0 .5 1log(Study RR)


BMI per 5kg/m2: Ovarian cancer inc



Studyauthor_year

Ma_2013

Kotsopoulos_2010_2

Lahmann_2009

Kotsopoulos_2010_1

1.04 (0.82, 1.31)

ES (95% CI)

1.18 (0.79, 1.76)

1.29 (0.82, 2.03)

1.12 (1.03, 1.22)

0.76 (0.61, 0.95)

100.00

%

Weight

18.44

15.97

36.94

28.64

1.04 (0.82, 1.31)

ES (95% CI)

1.18 (0.79, 1.76)

1.29 (0.82, 2.03)

1.12 (1.03, 1.22)

0.76 (0.61, 0.95)

100.00

%

Weight

18.44

15.97

36.94

28.64

1.491 1 2.03

0.0

5.1

.15

.2.2

5s.e

. o

f lo

g(S

tud

y R

R)

-.4 -.2 0 .2 .4 .6log(Study RR)


HC per 10cm: Ovarian cancer inc



Studyauthor_year

Chionh_2010

Folsom_2000

Ma_2013

Kotsopoulos_2010_2

Kotsopoulos_2010_1

Lahmann_2009

1.06 (1.00, 1.12)

ES (95% CI)

1.03 (0.87, 1.22)

1.11 (0.97, 1.27)

1.24 (0.99, 1.56)

1.18 (0.86, 1.62)

0.97 (0.83, 1.13)

1.04 (0.96, 1.13)

100.00

Weight

10.64

18.64

6.17

3.18

13.40

47.98

%

1.06 (1.00, 1.12)

ES (95% CI)

1.03 (0.87, 1.22)

1.11 (0.97, 1.27)

1.24 (0.99, 1.56)

1.18 (0.86, 1.62)

0.97 (0.83, 1.13)

1.04 (0.96, 1.13)

100.00

Weight

10.64

18.64

6.17

3.18

13.40

47.98

%

1.617 1 1.62

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.4 -.2 0 .2 .4log(Study RR)


WC per 10 cm: Ovarian cancer inc



Fairfield_2002

Jonsson_2003

Studyauthor_year

Lahmann_2009

Canchola_2010

Ma_2013

Schouten_2003

1.02 (0.96, 1.09)

0.91 (0.84, 0.98)

0.95 (0.75, 1.20)

ES (95% CI)

1.02 (0.97, 1.07)

1.03 (0.95, 1.12)

1.21 (1.05, 1.40)

1.07 (0.97, 1.18)

100.00

20.36

6.20

%

Weight

24.34

19.60

12.09

17.41

1.02 (0.96, 1.09)

0.91 (0.84, 0.98)

0.95 (0.75, 1.20)

ES (95% CI)

1.02 (0.97, 1.07)

1.03 (0.95, 1.12)

1.21 (1.05, 1.40)

1.07 (0.97, 1.18)

100.00

20.36

6.20

%

Weight

24.34

19.60

12.09

17.41

1.716 1 1.4

0.0

5.1

.15

s.e

. o

f lo

g(S

tud

y R

R)

-.2 -.1 0 .1 .2 .3log(Study RR)


WG per 5kg: Ovarian cancer inc



Schouten_2003

Studyauthor_year

Lahmann_2009

Lacey_2006

Ma_2013

1.03 (1.01, 1.05)

1.08 (0.99, 1.17)

ES (95% CI)

1.05 (1.02, 1.09)

Documents

Funnel plot with pseudo 95% confidence limits · 2017. 2. 28. · Overall (I-squared = 0.0%, p = 0.603) Engeland_2004 Lindblad_2005 Studyauthor_year MacInnis_2006 Lindblad_2005 Samanic_2006