Upload
others
View
2
Download
0
Embed Size (px)
Citation preview
Food Matters Live
Understanding the benefits of Matcha Green Tea for ageing and age related disease.
Professor Michael Lisanti
Katherine Swift – Founder of OMGTea
The OMGTea Story
At OMGTea we celebrate the full, chaotic and sometimes challenging lives that people lead.
We believe they’re extraordinary lives.
So our purpose is to bring them extraordinary
products to match.
So what exactly is matcha?
1. Tea Plant
2. Shaded
3. Steamed & Freeze dried
4. Ground
5. History
Problems we could tackle • + 50,000 women diagnosed with breast cancer in UK each year.
• In the UK, 64% of adults are classed as being overweight or obese.
64%
Obese
UK ADULT
POPULATION
The Science
• Professor
• Michael P. Lisanti
• MD-PhD, FRSA
• Chair of Translational Medicine
• University of Salford
• Greater Manchester, UK
• H-index >140
• >540 Publications
• >75,000 citations
The Science
Four Main Ageing Associated Diseases
• Heart Disease
• Diabetes
• Dementia
• Cancer
Overall Goal: Increase Healthspan
by Reducing Ageing Associated Diseases
The Clinical Problem
Tumor Recurrence, Metastasis
and
Drug Resistance
https://en.wikipedia.org/wiki/Cancer_stem_cell
Nature Reviews Clinical Oncology (April 2015)
0
0.2
0.4
0.6
0.8
1
1.2
CTRL 1μM 2μM 10μM 25μM 50μM 100μM 250μM
Tu
mo
ur-
Sp
he
re N
um
be
r (F
old
Ch
an
ge
)
MCF7 Cells - Breast
0
0.2
0.4
0.6
0.8
1
1.2
CTRL 1μM 2μM 10μM 25μM 50μM 100μM 250μM
Tu
mo
ur-
Sp
eh
ere
Nu
mb
er
(Fo
ld C
ha
ng
e)
T47D Cells - Breast
Doxycycline
Is there anything available as a
Dietary Supplement
or Nutraceutical,
that can mimic the beneficial effects
of Doxycycline ?
Proteomics Analysis
The Potential
Down-regulation (fold change) Green tea
Down-regulation (fold change) Doxycycline
PRKDC
PRKDC DNA-dependent protein kinase catalytic
subunit
24.43 14.71
GPD2
Glycerol-3-phosphate dehydrogenase, mitochondrial
2.10 5.29
ECI1
Enoyl-CoA delta isomerase 1, mitochondrial
1,698.11 2.95
HSPD1
60 kDa heat shock protein, mitochondrial
7.79 2.24
UQCRC2
Cytochrome b-c1 complex subunit 2, mitochondrial
65.99 1.91
SDHA
Succinate dehydrogenase complex subunit A
14.98 1.88
FASN Fatty acid synthase Infinity 1.83
ATP5F1
ATP synthase, H+ transporting, mitochondrial F0
complex, subunit b
3.52 1.57
Matcha Green Tea Shares
Mitochondrial Targets with Doxycycline
Matcha Green Tea Slows Down Mitochondrial Respiration
Matcha Green Tea Inhibits the Propagation of Cancer Stem Cells (CSCs)
Doxycycline also Increases Life Span
in C. elegans (worms),
a Model Organism for Ageing
The Potential
1. Matcha green tea drinks do not result in adverse physiological responses and could substantially enhance fat oxidation.
• Drinking matcha increases fat burning, which may boost weight loss for those undertaking regular exercise.
• Drinking matcha also had no adverse physiological effects such as raised heart rate or blood pressure.
“To be able to come out with these findings on fat oxidation and performance is just wonderful. I expect an increased interest to discover additional potential of matcha intake in the world of diet and exercise.”
Mark Willems, Professor in Exercise Physiology at the University of Chichester