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The Many Faces (Causes) of Insomnia

Most of you know by now that The FDA hasdetermined that phenibut does not meet thedefinition of a dietary ingredient, andtherefore, cannot be sold as or included in adietary supplement. In response, BioticsResearch has discontinued taking and shippingorders for all products containing phenibut.The products impacted by this arePheniTropic™, PheniTropic™ PM andPheniTropic™ Ultra PM.

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Just to be clear Biotics has never receivedan adverse event notification for anyproduct containing phenibut. Phenibutworks because it is a GABA derivative.GABA, gamma-aminobutyric acid, is thenumber one inhibitory neurotransmitter.

1. Excess glutamate2. Receptor sites that are compromised3. Lack of precursors to make serotonin,

melatonin and GABA4. Lack of trace minerals needed to buffer an

acidic chemistry5. Electromagnetic Fields EMFs

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6. Stress and anxiety which translates intoexcess cortisol

7. Over-oxidation of the brain

8. Excess copper

9. Dysglycemia

10. Inability to make sufficient cortisol

11. Environmental (i.e. temperature, mold)

• Try different approaches but remember whenyou go to any traditionally trained physician theymake recommendations and then readjust. It’scalled a clinical trial. Sleep is a complicatedissue. Scientists devote their whole careers tofinding clues and applying solutions.

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Phenibut is a form of GABA, the major inhibitoryneurotransmitter. Conversely Glutamate is the majorexcitatory NT. Think of them on a teeter totter; as onegets out of balance, for example goes up, the othergoes the opposite direction. So it’s important to reducedietary sources of Glutamate.

Glutamate increases as excitotoxins increase inones’ diet. Excitotoxins are food additives thatincrease glutamate and as a result reduce GABA.One example of an excitotoxins is MSG which isfound in many processed foods and fast foodrestaurants.

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Other excitotoxins include, hydrolyzed protein, sodiumcaseinate, calcium caseinate, disodium caseinate, autolyzedyeast, yeast extract, glutamic acid, carrageenan or vegetablegum, guar gum, bouillon, kombu extract, maltodextrin, manyseasonings and spices, soy extract, soy protein or soyprotein concentrate, or soy protein isolate, and soy sauce,textured protein, etc.

One of the biggest ways to increase GABA is to avoidexcitotoxins.

NutriClear Plus program

Patients are given foods to eat that are free ofexcitotoxins. This systematic program is easy,tastes great and trains patients to eradicate foodsthat are overstimulating.

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NutriClear Plus programXenoestrogens, plastics, pesticides, herbicides like Roundup,household chemicals block receptor sites so even ifhormones and NT are available they may not be able to dockon those sites adequately.

One of my core beliefs about health is we have to learn toclean the body and feed the body. The cleaner one’s diet theless nutrient support they will need.

• There may be more than one option for eachcategory.

• Based on geography and individual need.• For example we know milk thistle,

phosphatidylcholine and beets are all good examplesof agents that support liver function.

• You will see several options to reduce cortisol.

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• After the NutriClear Plus program or

• During the NutriClear Plus program or at a minimum

• While on the NutriClear Plus diet, one of my first choicesis:

• Neuro-5-HTP Forte 2 capsules

• Melatonin-B6/Mg 1 tablet• 30 minutes before bed.

• Neuro-5-HTP Forte – was designed to make sure thecofactors needed to convert 5-HTP to Serotonin and thenultimately to melatonin. If one is deficient in serotonin,even if sufficient levels of GABA are present, GABA maynot be able to perform its inhibiting effects adequately.

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• Melatonin-B6/Mg provides: 3 mg of melatonin, 10 mg ofP-5-P , 50 mg of magnesium glycinate

• Essential precursors needed to support the conversion ofserotonin to melatonin naturally.

• Melatonin (the yin) hormone helps us relax and repair;cortisol (the yang) keeps us alert, awake, on edge.

• Increase Melatonin and cortisol will naturally decrease

• Melatonin-B6/Mg

• Excess cortisol depletes melatonin.

• Cortisol reduces sex hormones.

• Melatonin controls the timing and release of hormones.Melatonin is also a major antioxidant, has antiviral,antibacterial qualities.

• The half-life is approximately 1 hour. TM #390

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• GABA is synthesized from the excitatory neurotransmitterglutamate by the enzyme glutamic acid decarboxylase(GAD). What's interesting is that GAD is only present inneurons that use GABA as a neurotransmitter. GAD cantransform the excitatory glutamate into the inhibitoryneuro-transmitter GABA but it needs B6 and Mg ascofactors. Each tablet of Melatonin-B6/Mg has 10 mg ofB6 in the activated P-5-P form.

• Neuro-5-HTP Forte (2) capsules

• Melatonin B6/Mg- (1)• 30 minutes before bed.

• If in 4 days patient is still not sleeping add a second doseduring dinner.

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• Melatonin-B6/Mg- contains 3 mg of melatonin in scoredtablet. Some people said they feel groggy with melatonin.The tablet is scored so they can take as little as 0.75mg.

• Doses as high as 20-40 mg are suggested as an immunemodulator.

• Li-Zyme Forte is a major intracellular alkalizing mineral, reducesstress in multiple ways.

• Enhancing brain function.

• Correcting pH allows enzymes and neurotransmitters to work attheir peak performance.

• Immune studies have shown that lithium will often preventreplication of viruses like herpes.

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• Lithium is known to alter sodium-potassium ratios and has beenlinked to decreasing blood pressure in patients who aregenetically pre-disposed to hypertension.

• Lithium is known to help reduce adreno-receptor cell stimulationby norephinephrine and cortisol.

• This combined with its effect on melatonin and circadian rhythmindicates lithium can be an effective adjunctive therapy withstress and sleep disorders related to stress.

• Lithium cont.

• Increase nitric oxide indicating it should be considered withunresolved male erection problems, circulatory problems andosteoporosis.

• Lithium as Li-Zyme Forte contains 150 mcg of elemental Lithiumin a polyphenol vegetable tableting base.

• Take 1-2 tid and take the final dose before bed.

• TM #520, # 361 gives a simple functional test to see if Lithiummay be valuable.

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• Magnesium is the most common mineral deficiency over 50% ofadult population is deficient by RDA standards.

• Necessary for over 300 enzymes systems in the body.

• Energy production….. It takes energy to relax.

• Magnesium displaces another GABA disrupter…lead.

• Mg-Orotate 500 or Mg-Zyme Caps are two source of magnesiumoffered by Biotics. Mg-Orotate 500 has less elementalmagnesium 31 mg per capsule. However it has been shown toincrease intracellular Mg. TM #243

• Great Sleep Alkalinizing combination:

• Li-Zyme Forte- 3 tablets (450 mcg

• Acti-Mag Plus -1 scoop in water or juice

OR

• Mg-Zyme - 4 capsules (400 mg).

• Biotics has many additional ways to alkalize the body such as PotassiumHP (with Magnesium) or NitroGreens but I like lithium and magnesium atnight to quiet the mind.

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• 57% of Americans do not get enough magnesium in their diet.

• Responsible for over 300 enzymes in the body.

• Important for energy production.

• Antianxiety properties: 3 out of 4 Americans report stressrelated symptoms

•

• Asthma • Blood Clots• Bowel disease • Cystitis• Depression • Diabetes• Fatigue & Irritability • Heart disease• Hypertension • Hypoglycemia• Insomnia • Kidney stones• Migraines • Muscle cramps• Nerve problems • PMS• Osteoporosis • Raynaud’s syndrome

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• Acti-Mag Plus:1 scoop

• 400 mg of magnesium Glycerophosphate

• 425 mg of organic beetroot juice

• 200 mg of bamboo shoot extract

• 200 mg Taurine

• B Vitamins in their phosphorylated form

• 200 mcg of Folate as 5-MTHFR

• Turn off Cell phones at night.

• Turn off Routers at night.

• Trace Minerals but especially Lithium as in Li-Zyme Forte hasalso been shown to combat EMFs which also disrupt sleep.

• Biotics tableting base is loaded with trace minerals, SOD andCatalase.

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• Diagnosed with elevated cortisol especially at night usuallysaliva, or 24 hour urine.

• Low serum Potassium

• Can’t seem to fall asleep- mind races

• Sympathetic dominance

• Check caffeine consumption etc.

• At some point the body becomes exhausted and then a depletionof cortisol ensures.

• De-Stress is a modified milk decapeptide shown to:• Reduce an overproduction of cortisol.

• Excess cortisol in turn reduces GABA.

• One animal study showed De-Stress worked as well or better thanvalium to reduce anxiety.

• Another study showed after 15 days, subjects taking De-Stressreported better sleeping and better perception of how their liveswere progressing.

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• De-Stress:• The normal dose for sleep is 2 at night.

• Severe Stress - I suggest 2 tid until they can experience a reductionin their stress states.

• In other words cut the dose as the stress cycle is broken whilemaintaining 2 at bedtime. TM# 358

• Ashwagandha is an adaptogenic herb for stressmanagement. I call it yin-energy because it increasesenergy but does it by modulating the parasympatheticnervous system.

• Benefits:• Reduce stress and anxiety by reducing cortisol

• Anti-oxidant, anticancer, antianxiety, antidepressant, cardio-protective.

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• Ashwagandha Benefits cont:• Thyroid modulating, immune-modulating, antibacterial, antifungal,

anti-inflammatory, neuroprotective, cognitive enhancing.

• Studies have shown it increases testosterone in exercising males.With all these benefits you don’t mind using it as a sleep aid,

• Ashwagandha as Bio-Ashwagandha contains 300mg per capsule.

• Use 300 mg as a tea 30 minutes before bed. See TM #452

PhosphatidylSerine

• Readily crosses the blood brain barrier.• Repairs cell membranes.• Some studies have shown Phosphatidylserine supports brain health

and the slowdown of age-related cognitive decline, combatsdepression, improves Parkinson’s disease symptoms, boosts athleticperformance, and treats ADHD Symptoms.

• Doses range from 300-800 mg per day.• Each capsule of Biotics PhosphatidylSerine contains 100 mg of PS.

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ADHS: Adrenal Hyper Secretor

Designed by Dr. Gary Lasneski. This product contains vitamins, minerals andherbs (product contains no glandular material), known to support normaladrenal function. Preliminary studies using the salivary adrenal stress test(ASI) indicate that ADHS is often effective as a supplement to increase DHEAwhile helping to normalize an increased or decreased cortisol level. ConsiderADHS with adrenal cortical hyperfunction (increased cortisol), hypertensiondue to adrenal hyperfunction, dysinsulinism (Syndrome-X/MetabolicSyndrome) and other cases where cortical hyperfunction is known orsuspected. Suggest 2-3 tablets, twice a day with breakfast and lunch.

Valarian Hops and Passionflower are three botanical agents thatsupport sleep. Some doctors have shared with me that this is theirfirst choice when patients complain of sleep disturbances.

Biotics has a product called V.H.P., each capsule contains:

200 mg of valerian root extract, 100mg of Hops and 100 mg ofPassionflower.

This combination of Gabanergic botanicals to reduce tension andstress can be used in capsules or as a tea.

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• Taurine readily crosses the blood brain barrier.

• Second most important inhibitory neurotransmitter in thebrain (GABA).

• Lowers glutamate levels.

• Inhibits microglial activation.

• Acts as an antioxidant.

• Inhibits inflammatory prostaglandins.

• Inhibits excess nitric oxide.

• Reduces brain swelling.

• Protects the blood brain barrier.

• Increases brain antioxidant enzymes like glutathione.

• Taurine is present in Neuro-5-HTP Forte but is also available separatelyin capsules as Taurine 500 mg per capsules and as a powder as Bio-CardioSirt BP. TM #450

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• Zinc

• Supports Neurotransmitter function

• Counters or displaces high copper which is excitatory

• Zinc as Zn-Zyme contains 15 mg per tablet

• Zn-Zyme Forte contains 25 mg per tablet

• Inositol as in Balanced-B8.

• Part of a secondary messenger system that passes signals fromoutside of the cell, through the membrane and transfersinformation inside the cell to the nucleus or targeted organelles.

• It appears to be most effective for people who are undermethylators.

• Both high and low blood sugar trigger excess glutamate andthus impair one’s ability to utilize GABA.

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• To enhance sleep for a 160 lb person, 650-2000 mg.

• Difficulty falling asleep take 30-60 minutes before sleep.

• Waking up in the middle of the night should take inositolimmediately before sleep.

• Balanced-B8 contains Inositol in a 40:1 Myo-inositol(MI) and D-chiro-inositol (DCI) blend. 1.5 tsp gives 5grams

• 5 grams can used throughout the day to support blood sugarregulation without drowsiness. TM # 453

• Clinical Pearl - Waking up in the middle of the night.

• As blood sugar drops cortisol is necessary to return blood sugarto optimal levels. Often that extra spike in cortisol will keepsomeone awake.

• In addition to inositol eating high quality fat and using Bio-Glycozyme Forte. Taking 3 before bed has been extremelyeffective.

• Bio-Glycozyme Forte helps the glycogen to glucose conversion.

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• Dr. Gary Lasneski found that some people are so depleted in cortisolthat they are in a constant state of inflammation. Most people tossand turn in their sleep or lay in weird positions.

• For the person who is deficient in cortisol this creates irritation andmild pain but it’s not enough to wake them but it is enough to keepthem in a mild sleep state.

• Never get into a deep restorative sleep.• Low cortisol can hinder the conversion of serotonin to melatonin and

cause sleep difficulty.

• Dr. Lasneski found that giving them cortisol support in the formof ADB5-Plus (3) at bedtime they received enough of a cortisolboost to get a great night sleep.

• This type of clinical trial should be done on a night when a goodnight sleep is not essential because there is a chance theadditional stimulation my cause wakefulness.

• Not your first option but one that you’ll want to be aware of foryour chronic fatigue, exhausted and burnt out patients.

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ADB5-Plus supports Adrenal HYPO Cortical Function (especially burnout)

• Normal dose : 2 tablets in the a.m. and 2 at noon.

Two tablets contain 75 mg of vitamin C, 5 mg of B-1, B-6 and B-2

(phosphorylated forms), 25 mg of B3, 200 mcg of folic acid, 6 mcg of vitamin B-12, 75 mgB 5, 500 mcg of iron, 35 mg of Mg malate, 2.5 mg of zinc, 1 mg of Mn.

635 mg proprietary blend: malic acid, porcine adrenal concentrate, citrus bioflavonoids,choline, SOD and catalase, N-acetyl-cysteine, ovine pituitary /hypothalamus,

bovine parotid, tyrosine (mushroom source), Rhodiola and copper

ADB5-Plus (3) at bedtime TM #465

I know I have given you a lot of options and things tothink about.

But if you systematically consider each of these, therewill be very few people that you will not bless with agood night sleep.

Thanks for watching I’ll see you next Tuesday.