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Final SessionSEARCH MULTIPLE

RESOURCES Knowledge Assessment

Merck Manual of Diagnosis and TherapyMedline (PubMed) Cochrane Library Clinical Evidence Science–Technology–Medicine + Cited Reference Search + Journal Impact Factor

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Searching – Finding - Appraising

Enuresis (Bedwetting) in school children:

Treatment options

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CLINICAL QUESTION FOR TODAY

Case 11-year old boy with enuresis (bedwetting) Urinary tract infections excluded; Frustrated with his health problem Possible treatment options:

1. Drug therapy (desmopressin)2. Enuresis alarm3. Combination of desmopressin + alarm?

Adapated from:BMJLearning http://http://learning.bmj.com

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BACKGROUND INFORMATIONDefinition of enuresis

(bedwetting) Merck Manual of Diagnosis and Therapy

http://www.merckmanual.com

Search: enuresis +desmopressin +alarms

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Enuresis – what it is aboutPrimary nocturnal enuresis Failure to have developed bedtime bladder control Usually caused by slow maturation of the nerves that

supply the bladder The child fails to awaken appropriately when the bladder

fills and needs emptying. affects 30% of children at age 4, 10% at age 6, 3% at age 12, and 1% at age 18.

It is more common in boys, Seems to be familial, Sometimes associated with sleep disorders.

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FOREGROUND QUESTIONTerminology enuresis; enuretic; bedwet; bedwetting drug(s); desmopressin; alarm(s)

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PubMed Search Strategy Suggestions

Step 1enure* OR bedwet* Limits: Title

Step 2desmopressin* OR drug* OR alarm* Limits: Title

Step 3Combine searches #1 AND #2

Step 4 Limits: Ages: Child 6-12

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PubMed Search Results (1)

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PubMed Search Results (2)All: 224

Reviews: 25 8 Cochrane Reviews of randomized

controlled trials

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Combination treatmentDrugs + alarms

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Professional Databases with Critically Appraised Topics

Clinical Evidencehttp://www.clinicalevidence.com (fee) Systematic reviews

Question(s) Option(s)

Grades of evidence Beneficial Likely beneficial Trade off between benefit and harm Unknown effectiveness Unlikely beneficial Etc.

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Clinical EvidenceInterventions: Questions

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CRITICAL APPRAISAL„Bibliometric Criteria“

Multidisciplinary database WEB OF KNOWLEDGE

Which journal was it written in? „Impact Factor“ = journal quality

Additional resources Journal Citation Reports (part of WoS)

Who wrote the article? Was the article cited by other articles?

Web of Science (part of WoK) Science Citation Index (tool)

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WEB OF SCIENCEMultidisciplinary

DatabasePalacky University Authorized Access at:

http://isiknowledge.com

Search Cited Reference Search Journal Citation Reports

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Which journal was it published in ?Journal Impact Factor

http://isiknowledge.comAdditional Resources – Journal Citation Reports

Cited author(s): Naitoh Y et al. Article title: Combination therapy with alarm and drugs for

monosymptomatic nocturnal enuresis not superior to alarm monotherapy..

Cited work: Urology Publication Year: 2005 Volume/Issue: 660/3 Pagination: 632-635.

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Search for a specific journal ….. Urology

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Urology Impact Factor2005 = 2.139

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UrologyImpact Factor CalculationCalculation Number of articles published in: 2004 = 584  +  2003 = 599 Sum: 1183 Number of cites in 2005 to articles published in:

2004 = 897 + 2003 = 1634

Sum: 2531 Cites to articles 2531 Number of articles 1183   = 2.139 Impact

factor

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Was article cited by other articles? Science Citation Index (SCI)http://isiknowledge.comCITED REFERENCE SEARCH

Cited author(s): Naitoh Y et al. Article title: Combination therapy with alarm and

drugs for monosymptomatic nocturnal enuresis not superior to alarm monotherapy..

Cited work: Urology Publication Year: 2005 Volume/Issue: 660/3 Pagination: 632-635.

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MORE ABOUT BIBLIOMETRICS Introduced in 1960s…„application of mathematical and

statistical methods to books and other media of communication“

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INSTITUTE FOR SCIENTIFIC INFORMATION & ITS FOUNDER

Eugene Garfield. Ph.D.

www.garfield.library.upenn.edu

1951 career in scientificcommunication and

information science

1960 founded ISI

2001- President, The Scientist.

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SCIENCE CITATION INDEX (SCI) has become the most generally accepted

source of bibliometrics. Citations became a widely used measure of

the impact of scientific publications as

signposts left behind after information has been utilized.

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CRITICAL APPRAISALIn generalTechnique, skill Increasing effectiveness of your

reading Excluding poorly designed studies Helping decide

which articles could influence your daily work

which are unsuitable.