Bioresponse Regulation

1. Wang et al. Macrophage Response Driven by Extracellular ATP. Biol Pharm Bull. 44, 599-604 (2021). 2. Omori et al. Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. Cell Rep.34, 108734 (2021). 3. Kawamura et al. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Ann Rheum Dis.

78, 1430-1437 (2019).4. Takahama et al. Autophagy limits activation of the inflammasomes. Immunol Rev. 281, 62-73 (2018).5. Takahama et al. The RAB2B - GARIL5 complex promotes cytosolic DNA - induced innate immune responses. Cell Rep. 20, 2944-2954 (2017).6. Kozaki et al. Mitochondrial damage elicits a TCDD - inducible poly (ADP-ribose) polymerase - mediated antiviral response. Proc Natl Acad Sci

USA. 114, 2681-2686 (2017).7. Misawa et al. Organelle Contact Sites: From Molecular Mechanismto Disease. Mitochondria - endoplasmic reticulum contact sites mediate innate

immune responses. Adv Exp Med Biol. 997, 187-197 (2017).8. Sasai et al. Essential role for GABARAP autophagy proteins in interferon - inducible GTPase - mediated host defense. Nat Immunol. 18, 899-910 (2017).9. Imagawa et al. Vital staining for cell death identifies Atg9a - dependent necrosis in developmental bone formation in mouse. Nat Commun. 7,

13391 (2016).10. Saitoh & Akira. Regulation of inflammasomes by autophagy. J Allergy Clin Immunol. 138, 28-36 (2016).11. Int Immunol. 27, 425-434 (2015).

Outstanding Merit Award 2015 受賞論文12. Misawa et al. Microtubule - driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 14, 454-460

(2013).13. Saitoh et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 456, 264-268 (2008).

教　授 齊藤　達哉 Professor Tatsuya SAITOH 06-6879-8170 saitohtatsuya@phs.osaka-u.ac.jp講　師 武村　直紀 Lecture Naoki TAKEMURA 06-6105-5793 takemura-na@phs.osaka-u.ac.jp助　教 田浦　　学 Assistant professor Manabu TAURA 06-6105-5793 taura@phs.osaka-u.ac.jp

教　授　齊藤　達哉

１）ウイルス、細菌、がん細胞などの排除に関わる免疫応答の解明２）アレルギー疾患、自己免疫疾患、生活習慣病などの発症に関わる誤った免疫応答の解明

３）免疫応答の制御を基盤とする治療薬の開発４）本分野のホームページも参照くださいhttp://saitohtatsuya.wixsite.com/saitohlab

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