Ca2+ channel

Neurotransmitters

PiccoloBassoon

Actin

Actin

Synapticvesicle

Early endosome

ClathrinCa2+

Rab3

APC

PRA1

RIM

Eph

rinA

Eph

A

Eph

rinB

Eph

B

LAR

Net

rinG

NGL

Neu

rexi

nN

euro

ligin

LRR

TM

nCad

herin

SNAP25 SNAP25

Syntaxin SyntaxinSySMUNC18

MUNC13

SyntaxinS

NMUSynaptobrevin

Syn

deca

n

SSyntaxinSynaptobrevin

nCad

herin

CN

RC

N R

Syn

Cam

Syn

Cam

CASK

VelisMINT

PRA1

mGluR

ACh R

Kainate R

nnel

AMPA RNMDA R

Axonalguidance

Actinreorganization

Spinogenesis Synapse development,function, and plasticity

Neuronalsurvival

Receptortrafficking

Synapticsignaling

mGluR

PSD95

PSD95

PSD95

Fz RWNT

Homer

Homer

Cortacin

ProSAP/Shank

GSK3 β

Spectrin

AXIN

β CatAPC

Gi/o

Ca2+

Ca2+ channel

GDP

GTP

GTP

GDPGTP

GDP

Ca2+

UbUb

Ub

Ub

Ca2+

Ca2+

Ephexin1

Src

Vav2

Syntenin

TiamKalirin7

Src

CaM

Calcineurin

CaM

Src

2+

AKAP79/150

PKAAAA Calcineurin

AKAP79/150Src

PKAU

AAA Calcineurin

PP1

PRho

GRho

PRac

GRac

Kalirin7 CaMKII

DPRas

GRas

RASGRFNFAT

NFκB

CaMKKCaMKIBetaPIX

RAF

MEK

ERK

p190RhoGAP

GK

AP

/S

APA

P

A

MaGUK

Arc

b

SynG

ap Arc

Ub

CS

P α

SVOP

Rab5

/3A/

3B/3

C

SO

PSVO

SV2 (2A,2B,2C)

A/3B

SynapsinS

SynaptotagminSynptogyrin

SynaptobrevinSynptophysint

SCA

MPVti1a β

Copyright © 2012 Abcam, All Rights Reserved.

Excitatory synapse

Discover more at abcam.com/biochemicalsProduced in collaboration with Paul L. Greer, Ph.D., Harvard Medical School

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Excitatory synapse related products from Abcam Biochemicals

Discover more at abcam.com/biochemicals

Product Biological description Purity Product code

Muscarinic Acetylcholine Chloride Endogenous neurotransmitter active at acetylcholine receptors - ab1204694-DAMP Muscarinic receptor antagonist >98% ab120144Pirenzepine dihydrochloride Selective M1 receptor antagonist >99% ab120153

Nicotinic (±)-Anatoxin A fumarate Potent nicotinic agonist >98% ab120013α-Bungarotoxin Subtype-selective α7 nAChR antagonist >99% ab120542Methyllycaconitine citrate α7-nicotinic receptor antagonist >98% ab120072PNU 282987 Selective α7 nAChR agonist >99% ab120558(+)-Tubocurarine ACh receptor antagonist >99% ab120073Vecuronium bromide Competitive nicotinic acetylcholine receptor (nAChR) antagonist - ab120536

Glutamate: broad spectrum/non-selective DL-AP4 Broad spectrum glutamate antagonist >99% ab120001L-Glutamate Excitatory neurotransmitter >99% ab120049Ibotenic acid Excitotoxic agonist >98% ab120041Kynurenic acid sodium salt Endogenous ionotropic / nicotinic antagonist; water soluble >99% ab120256

Glutamate: mGlu AMN082 dihydrochloride mGlu7 agonist >99% ab120011L-AP4 Selective group III mGlu agonist >99% ab120002(R,S)-CHPG Selective mGlu5 agonist >98% ab120039Cinnabarinic acid Endogenous mGlu4 selective agonist >98% ab120506(S)-3,5-DHPG Selective group I mGlu agonist >99% ab120007LY 341495 Potent, selective group II antagonist. Group III antagonist at higher concentrations >98% ab120199LY 367385 mGlu1a antagonist >99% ab120067(S)-MCPG Group I / II mGlu antagonist >98% ab120059mGlu Agonists Kit A collection of 7 agonists and modulators for a range of mGlu receptor subtypes - ab120321

Glutamate: mGlu (continued)mGlu Antagonists Kit A collection of 6 antagonists for mGlu receptor subtypes - ab120322MMPIP mGlu7 allosteric antagonist >98% ab120245MPEP hydrochloride Potent, selective mGlu5 antagonist >99% ab120008YM 202074 mGlu1 antagonist >98% ab120293

Glutamate: NMDA D-AP5 NMDA glutamate site antagonist >99% ab1200037-Chlorokynurenic acid sodium salt NMDA receptor glycine site antagonist; water soluble >99% ab120255(R)-CPPene Potent competitive NMDA antagonist >98% ab1202325,7-Dichlorokynurenic acid sodium salt NMDA receptor glycine site antagonist; water soluble >99% ab120254(+)-MK 801 maleate Non-competitive NMDA antagonist >99% ab120027NMDA Excitotoxic amino acid >98% ab120052UBP141 GluN2D (formerly NR2D) antagonist, with some subunit selectivity >98% ab120193

Glutamate: AMPA&Kainate (S)-AMPA AMPA agonist >98% ab120005CNQX disodium salt AMPA / kainate antagonist (water soluble) >99% ab120044GYKI 53655 hydrochloride Non-competitive AMPA / kainate receptor antagonist >99% ab120490Ionotropic Agonists Kit A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. - ab120323Kainic acid Prototypic kainate receptor agonist >99% ab120100NBQX disodium salt AMPA / kainate antagonist (water soluble) >98% ab120046

Calcium channel ω-Agatoxin IVA Ca2+ channel blocker (P and Q type) >95% ab120210ω-Conotoxin GVIA Ca2+ channel blocker (N type) >96% ab120215SNX 482 R-Type Ca2+ (Cav2.3) channel blocker >96% ab120259Verapamil hydrochloride L-type Ca2+ channel blocker >99% ab120140

Pitstop 2™ clathrin inhibitor - World exclusive! (ab120687)

Novel, selective, cell membrane permeable clathrininhibitor. Competitively inhibits clathrin terminaldomain to selectively inhibit clathrin mediatedendocytosis (IC50 = 12 μM for inhibition ofamphiphysin association of clathrin terminal domain).Interferes with receptor mediated endocytosis, entryof HIV and synaptic vesicle recycling.

Featured products

Product Biological description Purity Product code

RuBi-Glutamate: A novel light-sensitive,caged ligand (ab120408)

• Activated by visible wavelengths of light• No need for harmful UV light or expensive quartz optics• Fast uncaging speeds - single photochemical step

Releases glutamate after one- or two- photon excitation.Can be used at low concentrations. Enablesphotoactivation of neuronal dendrites and circuits.Other caged compounds include RuBi-GABA (ab120409),RuBi-nicotine (ab120450) and RuBi-AP (ab120410)

Fluorescent false neurotransmitter - highlyefficient optical tracer of dopamine (ab120331)

Fluorecsent false neurotransmitter (FFN) acts as asubstrate for the synaptic vesicle monoamine transporter.

• Resolution seen at individual synaptic level• Concentration required does not interfere with

normal synaptic function• Compatible with GFP-based tags and other

optical probes