Ethical issues

related to animal use in

biomedical research

Diarsvitri W1, Triakoso N2, Ashrin MN1, Trisyani N1

1 Research Ethics Committee, Hang Tuah University, Surabaya. 2 Research Ethics Committee, Faculty of Veterinary Medicine,

Airlangga University, Surabaya, Indonesia.

13th FERCAP, 18-19 November 2013, Bali, Indonesia

BACKGROUND

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CANNOT

CONSENT

KILLED

LIMITED

FREEDOM

ETHICAL ISSUES

DISTRESS &

PAINFUL

INTERVENTIO

N

NO BENEFIT

FROM

PARTICIPA-

TION

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Festing & Wilkinson, 2007

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Animal welfare is very important

Resource-limited setting:

A long-term goal: complete

replacement of using animals

Mandatory goal: reduce the

number of animals used and

advancing refinement.

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Refinement

to alleviate or minimize the pain,

distress and other adverse

effects suffered by the animals

involved or enhance animal

well-being.

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OBJECTIVE

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As of January 2013, Hang Tuah University has required its students to apply the research ethics.

The objectives of this study to evaluate issues related to the use of

animals in the undergraduates’ biomedical research proposals

how the Research Ethics Committee advances the refinement of animal use in their researches.

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METHODS

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All undergraduate biomedical

research proposals involving

experimental animals in the

period of January to June 2013

(32 proposals) were evaluated

descriptively

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Ethical review

Contribution to knowledge

Objectives: realistic, original, timely?

Design: Choice & number of animals used

Experimental design refinement

Competence of staff

Appropriate facilities

Communication of results Diarsvitri et al.

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RESULTS

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Experimental animal used in all

32 proposals: Rattus norvegicus

Wistar strain.

10 proposals (31,3%): calculation

of sample size has been

corrected to conform with the

reduce principle.

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30 proposals (93,8%) were:

derived from 14 herbal medicine &

marine product researches: S.

polycysticum, M. charantia, M.

oleifera, red yeast rice, A. antiquata

shell powder.

used to treat chronic degenerative

diseases (dyslipidemia), increase

antioxidant and wound healing.

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2 proposals (6,2%) were:

derived from one hyperbaric

research.

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19 proposals (59,4%): needed a

change of

experimental design (pretest

posttest to posttest only control

group design)

better care of the animals

approriate pain management

better euthanasia procedure.

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CONCLUSION

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Consideration of practical and ethical aspects of laboratory animal use should be included in undergraduate biomedical courses.

A need to improve appreciation and commitment to advancement of refinement principle.

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REFERENCES

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Festing, S., Wilkinson, R. 2007. The ethics of animal research. Talking point on the use of animals in scientific research. EMBO Reports 8(6): 526-30.

Gilbert, S., Kaebnick, G.E., Murray, T.H (eds). 2012. Animal research ethics. Evolving views and practices. A Hasting Center Special Report.

McGill University Animal Care Committee. 2009. The laboratory mouse. Handling and restraint.

Olsson, IAS., Robinson, P., Sandoe, P. 2010. Ethics of animal research. In: Hau, J., Schapiro, SJ (eds). 2010. Handbook of laboratory animal science. Vol. 1. 3rd ed. Essentials principles and practices.

Pitts, M., Bayne, K. (eds). 2002. Institutional animal care and use committee guidebook. 2nd ed. Office of Laboratory Animal Welfare. National Institutes of Health.

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THANK YOU

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