Eosinophilic Esophagitis – Advancing Science for Everyday ... · Eosinophilic Esophagitis – Advancing Science for Everyday Challenges in Clinical Practice November 20-21, 2020

Preliminary Program

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Application for CME credits submitted

Organized by:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49-761-1514-125Telefax: +49-761-1514-359E-Mail: symposia@falk-foundation-symposia.orgwww.falk-foundation-symposia.org

Symposium 222

Eosinophilic Esophagitis –Advancing Science for Everyday Challenges in Clinical Practice

November 20-21, 2020Swissôtel ZurichZurich, Switzerland

Organized by:


Telephone: +49-761-1514-125 Telefax: +49-761-1514-359 E-Mail: [email protected] www.falk-foundation-symposia.org

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22375_Falk_Zurich_Symp_222_PremProg_UG.indd 122375_Falk_Zurich_Symp_222_PremProg_UG.indd 1 06.02.20 10:2506.02.20 10:25

1

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 4

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

List of Speakers, Moderators and Scientific Organizers . . . . . . . . . . . . . . . . . . . . . . . 11

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

CME credits for the Symposium 222 have been applied for at the European Union of Medical Specialists (UEMS) . The number of credits awarded will be printed in the final program .

22375_Falk_Zurich_Symp_222_PremProg_Inhalt.indd 122375_Falk_Zurich_Symp_222_PremProg_Inhalt.indd 1 06.02.20 10:2506.02.20 10:25

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Preface

Dear colleagues,

The organizing committee is delighted to invite you all to the Symposium “Eosinophilic Esophagitis – Advancing Science for Everyday Challenges in Clinical Practice”, that will be held in Zurich, a beautiful city at the lakeside and in direct proximity to the Swiss Alps . It was back in 1989 that in the middle of the Swiss countryside - less than a 30 minutes train ride from Zurich - one of the first patients diagnosed with a novel esophageal disease, that had yet awaited proper medical description, presented with food impaction for several hours and caught the immediate attention of one of our colleagues from the organizing committee .

The rest of this story is part of the medical history of diseases of the esophagus: Almost coincidently Steven Attwood and Alex Straumann in 1993 and 1994 provided their first description of the disease, each with a handful of patients suffering from an “idiopathic”, “distinct clinicopathologic syndrome” characterized by “esophageal eosinophilia” and “dysphagia”, which despite “typical clinical aspects” but rather “discrete endoscopic findings” was “frequently overlooked” .

Now having surpassed its late twenties, Eosinophilic Esophagitis (EoE) is still a young disease . Despite this young age, a cornucopia of scientific and clinical milestones have been achieved with an impressively active global research collaboration . We are excited and honored to host over two dozen world-renowned experts in the field of EoE . Our symposium has two main purposes: First to present the current scientific advances in our understanding of EoE’s pathogenesis, and second to provide translational bridges from bench to bedside, where physicians are confronted with EoE and overlapping conditions . On behalf of the entire organizing committee and all speakers, it is with great pleasure that we invite you to participate in this Symposium and we very much look forward to welcoming you in Zurich in November 2020 .

Luc Biedermann Glenn T . Furuta Thomas Greuter David Katzka Alex StraumannZurich Aurora Zurich Rochester Zurich


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Symposium 222



Start of Registration:Thursday, November 19, 202016 .00 - 21 .00 hat the congress office

Setting Up of Poster Session:Thursday, November 19, 202016 .00 - 21 .00 h

Congress Venue:Swissôtel ZurichSchulstr . 448050 ZurichSwitzerland

Symposium 222 is organizedby Falk Foundation e.V.

Scientific Organization:Dr . Luc BiedermannDepartment of Gastroenterology and HepatologyUniversity Hospital ZurichRämistr . 1008091 ZurichSwitzerlandTelephone: + 41-44-255-1111luc .biedermann@usz .ch

G .T . Furuta, Aurora (USA)T . Greuter, Zurich (Switzerland)D .A . Katzka, Rochester (USA)A . Straumann, Zurich (Switzerland)

Official Language:English

Call for Posters:A poster session will take place . For details see page 10

Publication Date of the Final Program: November 2020

The final program will be available on the homepage www .falk-foundation-symposia .org one week before the start of the symposium .


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Friday, November 20, 2020 “Science & Diagnostics”

9.00 Welcome Scientific committee

Session I Clinical Presentation

Chair: L . Biedermann, Zurich; D . Katzka, Rochester

9.10 My first EoE patient - What has changed in the S . Attwood, last 30 years? Durham

A . Straumann, Zurich

9.30 The epidemiology of EoE: Who and where are E .T . Jensen, the patients? Winston-Salem

9.50 Children and EoE: How are pediatric patients M . Chehade, different from adults? New York

10.10 Phenotypes in EoE: What diagnostic pitfalls should T . Greuter, you be aware of? Zurich

10.30 Esophageal Food Impaction (EFI) - How do you manage N . Gonsalves, EoE related food impactions? Chicago

P . Schreiner, Zurich

10.50 Coffee break with poster session

Session II Pathogenesis

Chair: I . Hirano, Chicago; H .-U . Simon, Bern

11.20 EoE: Is it an allergy and why would that matter? J .M . Spergel, Philadelphia

11.40 The role of eosinophils: Mission accomplished? S .J . Ackerman, Chicago

12.00 EoE beyond eosinophils: Is there an inflammatory H .-U . Simon, dysphagia syndrome? Bern

12.20 Fibrosis and EoE - Do all patients develop clinically S . Aceves, meaningful fibrosis? San Diego

12.40 Lunch break with poster session


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Session III Endoscopy

Chair: F . Moawad, La Jolla; A . Schoepfer, Lausanne

14.00 Why should we rely on more than symptoms to E . Safroneeva, assess disease activity? Bern

14.20 EoE Histology Scores: What and why? M . Collins, Cincinnati

14.40 EREFS & Co . – Why do we need standardized scores in A . Schoepfer, our daily clinical practice? Lausanne

15.00 Novel diagnostic tools: Ready for prime time? D . Katzka, Rochester

15.20 State-of-the-Art Lecture I . Hirano, The role of endoscopy in 2020 Chicago



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Workshops Venue: Panorama Floor Registration: Free to attend, limited spaces!

16.00 – 16.40 Workshop 1 A . Weber, Zurich and Histology experts M . Collins, Cincinnati 16.50 – 17.30

16.00 – 16.40 Workshop 2 J . Spalinger, Luzern and Kids club S . Gupta, Peoria 16.50 – 17.30

16.00 – 16.40 Workshop 3 E . Savarino, Padova and Difficult cases to diagnose P . Juillerat, Bern 16.50 – 17.30

16.00 – 16.40 Workshop 4 A . Schoepfer, Lausanne and Hands-on workshop dilatation F . Moawad, La Jolla 16.50 – 17.30

16.00 – 16.40 Workshop 5 P . Schreiner, Zurich and Pregnancy and EoE M . Chehade, New York 16.50 - 17.30

17.30 Networking with light refreshments Venue: Convention Floor


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Saturday, November 21, 2020 “Therapeutics”

Session IV Breakfast Sessions – Meet the professor

Registration: Free to attend, limited spaces! Breakfast included.

7.45 – 8.30 Endoscopy in EoE: Tips and tricks I . Hirano, Chicago

C . Schlag, Munich

7.45 – 8.30 What you always wanted to know, S . Miehlke, but never dared to ask Hamburg

P . Hruz, Basel

7.45 – 8.30 My EoE kid is growing up – S . Gupta, Pediatric to adult transition Peoria

C . A . Liacouras, Exton

Session V Drugs & Dilation

Chair: A .J . Bredenoord, Amsterdam; E .S . Dellon, Chapel Hill

9.00 PPI - How? How much? How long? J . Molina-Infante, Cáceres

9.20 Steroids - How? How much? How long? L . Biedermann, Zurich

9.40 Endoscopic techniques for dilation: Balloon or Bougie? F . Moawad, La Jolla

10.00 Diet - Where do we stand? N . Gonsalves, Chicago

10.20 Long-term Management of EoE: T . Greuter, Is lifelong treatment needed for every patient? Zurich



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Session VI Scientific Session

Chair: D . Katzka, Rochester; A . Straumann, Zurich

11.00 Oral poster presentation 1 N .N .



11.30 From bench to bedside – summary of selected abstracts D . Katzka, and possible implications Rochester

11.50 Esophageal hypersensitivity and reflux: A . Lund-Krarup, Overlap with EoE – and a potential driver thereof Hjørring

12.10 State-of-the-Art Lecture Practical implications for the patient surrounding G . Furuta, treatments and pathophysiology Aurora

12.30 Lunch break with poster session


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Session VII Future perspectives (Diagnosis & Treatment)

Chair: L . Biedermann, Zurich; G . Furuta, Aurora; T . Greuter, Zurich; D . Katzka, Rochester

14.00 Novel steroid formulations: S . Miehlke, What’s here and what’s on the horizon? Hamburg

14.20 Endoflip/Esoflip A .J . Bredenoord, Amsterdam

14.40 Evolving concepts in diet A .J . Lucendo, Tomelloso

15.00 Emerging biologics E .S . Dellon, Chapel Hill

15.20 How to manage EoE in 2043? A . Straumann, Zurich

15.40 Closing remarks and Farewell Scientific committee


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Poster SessionPosters will be exhibited on November 20-21, 2020 . The authors will be in attendance during coffee and lunch breaks on both days . The set-up of the poster session starts on Thursday, November 19, 2020 at 16 .00 h . The authors are asked to mount their poster on Thursday .

Call for PostersPlease submit your poster abstract before September 1, 2020 . Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted .

Abstracts must be submitted via our Internet Abstract Submission System (https://poster .falkfoundation .com) where further information regarding the submission format and the submission process is available .

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program . The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting .

The authors will receive notification about acceptance and further instructions in October 2020.

Contact address for further information on the poster session:

Falk Foundation e .V .Congress DepartmentLeinenweberstr . 579108 Freiburg GermanyTelephone: +49-761-1514-125Telefax: +49-761-1514-359

Web address for submitting poster abstracts: https://poster .falkfoundation .com

For the first author of an accepted poster, expenses for accommodation (November 19-22, 2020) and fees for the scientific program will be covered during Symposium 222 . Travel expenses will not be covered .

Poster AwardsThree prizes will be awarded for the best poster presentations . For the presentation of poster awards, award winners will be asked to give a short presentation (2–5 minutes) of their poster. Award winners will be presented with a certificate and prize money of €1,500, €1,000 and €500 . Travel expenses will additionally be covered for the first author of an awarded poster .


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List of Speakers, Moderators and Scientific Organizers

Seema Aceves, M.D., Ph.D.Professor, Pediatrics and MedicineDirector EGID ClinicDivision of Allergy ImmunologyRady Children’s Hospital San DiegoUniversity of California, San Diego 3020 Children‘s WaySan Diego, CA 92123USAsaceves@health .ucsd .edu

Steven J. Ackerman, Ph.D.Department of Biochemistry and Molecular GeneticsMBRB2074, M/C669University of Illinois at Chicago900 S . AshlandChicago, IL 60607USAsackerma@uic .edu

Prof. Dr. Stephen AttwoodDepartment of Health Services ResearchQueen’s campusDurham UniversitySouth RoadDurham, DH1 3LEGreat Britainseaattwood@gmail .com

Dr. Luc BiedermannDepartment of Gastroenterologyand HepatologyUniversity Hospital ZurichRämistr . 1008091 ZurichSwitzerlandluc .biedermann@usz .ch

Dr. Arjan J. BredenoordDepartment of Gastroenterologyand HepatologyAcademic Medical CentrePO Box 227001100 DE AmsterdamThe Netherlandsa .j .bredenoord@amsterdamumc .nl

Mirna Chehade, M.D., MPHAssociate Professor of Pediatrics and MedicineMount Sinai Center for Eosinophilic DisordersIcahn School of Medicine at Mount SinaiOne Gustave L . Levy Place, Box 1198New York, NY 10029USAmirna .chehade@mssm .edu

Margaret H. Collins, M.D.Division of Pathology ML 1035Cincinnati Children‘s Hospital Medical Center3333 Burnet AvenueCincinnati, OH 45229USAmargaret .collins@cchmc .org

Evan S. Dellon, M.D.Professor of MedicineDivision of Gastroenterology and HepatologyUniversity of North Carolina at Chapel HillBioinformatics Building CB# 7050130 Mason Farm RoadChapel Hill, NC 27599USAevan_dellon@med .unc .edu

Glenn T. Furuta, M.D.Professor of Pediatrics, Gastroenterology,Hepatology & Nutrition, B290The Children‘s Hospital13123 East 16th AvenueAurora, CO 80045USAglenn .furuta@childrenscolorado .org


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Nirmala Gonsalves, M.D.Professor of MedicineDivision of Gastroenterology & HepatologyNorthwestern University - The Feinberg School of Medicine676 N . St . Claire, Suite 1400Chicago, IL 60611USAn-gonsalves@northwestern .edu

Thomas Greuter, M.D.Department of Gastroenterologyand HepatologyUniversity Hospital ZurichRämistr . 1008091 ZurichSwitzerlandthomas .greuter@usz .ch

Sandeep Gupta, M.D.Pediatric Subspecialty ClinicOSF Children’s Hospital of Illinois420 NE Glen Oak AvenueSuite 20161603 Peoria, IllinoisUSAskgupta@uic .edu

Ikuo Hirano, M.D.Professor of MedicineNorthwestern University676 North St . Clair StreetChicago, IL 60611USAi-hirano@northwestern .edu

Prof. Dr. Dr. Petr HruzDepartment of Gastroenterology and HepatologyUniversity Hospital BaselPetersgraben 44031 BaselSwitzerlandpetr .hruz@usb .ch

Elizabeth T. Jensen, MPH Ph.D.Department of Epidemiology and PreventionDivision of Public Health Sciences Division of Gastroenterology (joint)Department of MedicineWake Forest School of MedicineMedical Center Boulevard Winston-Salem, NC 27157USAejensen@wakehealth .edu

PD Dr. Pascal JuilleratUniversitätsklinik für Viszerale Chirurgie und MedizinBauchzentrum BernInselspitalFreiburgstrasse3010 BernSwitzerlandpascal .juillerat@insel .ch

David Katzka, M.D.Division of Gastroenterologyand HepatologyMayo Clinic200 First Street SWRochester, MN 55905USAkatzka .david@mayo .edu

Anne Lund Krarup, M.D., Ph.D.Associate ProfessorDepartment of Gastroenterology, 205AThe North Denmark Regional HospitalBispensgade 379800 HjørringDenmarkapslk@rn .dk

Chris A. Liacouras, M.D.Professor of Pediatric GastroenterologyThe Division of Gastroenterology, Hepatology and NutritionThe Children‘s Hospital of PhiladelphiaExton Specialty CenterUniversity of Pennsylvania481 John young WayExton, PA 19341USAliacouras@email .chop .edu


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Dr. Alfredo J. LucendoHospital General de TomellosoDepartment of GastroenterologyVereda de Socuéllamos, n/n13700 TomellosoSpainajlucendo@hotmail .com

Prof. Dr. Stephan MiehlkeCenter for Digestive DiseasesInternal Medicine Center Eppendorfand Center for Esophageal DisordersUniversity Hospital EppendorfEppendorfer Landstr . 4220249 HamburgGermanyprof .miehlke@mdz-hamburg .de

Fouad Moawad, M.D.Division of Gastroenterology Scripps ClinicAnderson Medical Pavilion9898 Genesee AveLa Jolla, CA 92037USAfmoawad@hotmail .com

Dr. Javier Molina-InfanteDepartment of GastroenterologyHospital Universitario de CaceresAvda Universidad 7510004 CaceresSpainxavi_molina@hotmail .com

Dr. Ekaterina SafroneevaInstitute of Social and Preventive MedicineUniversity of BernMittelstrasse 433012 BernSwitzerlandekaterina .safroneeva@ispm .unibe .ch

Prof. Dr. Edoardo SavarinoDepartment of Surgery, Oncologyand Gastroenterology (DISCOG)University of PaduaVia Giustiniani 235121 PadovaItalyedoardo .savarino@unipd .it

Dr. Christoph SchlagInnere Medizin IIKlinikum rechts der IsarIsmaninger Str . 2281675 MunichGermanychristoph .schlag@mri .tum .de

Prof. Dr. Alain SchoepferDepartment of GastroenterologyCHUVUniversity of LausanneRue du Bugnon 441011 LausanneSwitzerlandalain .schoepfer@chuv .ch

Dr. Philipp SchreinerDepartment of Gastroenterologyand HepatologyUniversity Hospital ZurichRämistr . 1008091 ZurichSwitzerlandphilipp .schreiner@usz .ch

Prof. Hans-Uwe Simon, M.D, Ph.D.Institute of PharmacologyUniversity of BernInselspital, INO-FFriedbühlstr . 493010 BernSwitzerlandhans-uwe .simon@pki .unibe .ch

Dr. Johannes SpalingerPediatric gastroenterology and nutritionChildren’s Hospital LuzernSpitalstr .6000 LuzernSwitzerlandjohannes .spalinger@luks .ch


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Jonathan M. Spergel M.D., Ph.D.Allergy SectionThe Children‘s Hospital of PhiladelphiaPerelman School of Medicine at the Univ . of PennsylvaniaWood 3325D3401 Civic Center BlvdPhiladelphia, PA 19104USAspergel@email .chop .edu

Prof. Dr. Alex StraumannHead of Swiss EoE Clinics and Research NetworkDepartment of Gastroenterology and HepatologyUniversity Hospital ZurichRämistr . 1008006 ZurichSwitzerlandalex .straumann@hin .ch

Achim Weber, M.D.Professor of PathologyDepartment of Pathology and Molecular PathologyInstitute of Molecular Cancer Research (IMCR)University (UZH) & University Hospital (USZ) ZurichSchmelzbergstrasse 128091 ZurichSwitzerlandachim .weber@usz .ch


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General InformationPrior to the opening of the Symposium in Zurich

Falk Foundation e .V . Telephone: +49-761-1514-125Congress Department Telefax: +49-761-1514-359Leinenweberstr . 5 Email: symposia@falk-foundation-symposia .org79108 FreiburgGermany

Congress Office and RegistrationDuring Symposium 222

Congress Office Telephone: +49-175-7795-327

Opening Hours:Thursday, November 19, 2020 16 .00 – 21 .00 hFriday, November 20, 2020 8 .00 – 17 .30 hSaturday, November 21, 2020 7 .15 – 16 .00 h

Workshop Venue:Swissôtel ZurichSchulstrasse 448050 ZurichSwitzerland

Congress FeesScientific Program of Symposium 222 EUR 300Students (copy of student ID required) EUR 150

* * *OR* **

Day Ticket EUR 180Students (copy of student ID required) EUR 90

The congress fees include:- Pre-Opening and Welcome on Thursday, November 19, 2020- Refreshments during coffee breaks- Breakfast during Breakfast Session on Saturday, November 21, 2020- Lunch on Friday, November 20 and on Saturday, November 21, 2020- Snacks during networking on Friday, November 20, 2020- A copy of the abstract volume- A copy of the final program


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RegistrationCongress registrations must reach the Falk Foundation e .V . by August 15, 2020, at the latest. You can register either online: www .falkfoundation .de or by sending the registration card .

After receipt of the registration, each participant will be provided with a confirmation of his registration/invoice . On presentation of this confirmation at the congress office in Zurich, participants will receive the congress folder containing name badge, admission tickets and the abstract volume .

In the event of registration cancellations, a handling fee of EUR 20 will be deducted from the refund . All participants will receive a written confirmation of attendance at the end of the meeting .

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible .

Accompanying persons are not permitted during the conference at any time .

Arrival By planeThe distance between Zurich Airport and the hotel is around 6 kilometers and a car ride will take approximately 15 minutes . There are several trains to Swissôtel from the airport: S2, S16 or IR train . Cost for single ticket, zone 10/11: 4,20 CHF .

The hotel is situated directly opposite the station Oerlikon . Further information can be found under: https://www .zurich-airport .com

Taking a taxi from the airport will cost approx . 30-40 CHF and will take about 15 minutes .

By public transportFrom Zurich main station to Oerlikon station you can take train S2, S5, S6, S8, S14, S16 or IR (about 7 minutes) .

Cost for single ticket, zone 10: 2,60 CHF . The hotel is situated directly opposite Oerlikon station .

Taking a taxi from the main station will cost approx . 30-40 CHF and will take about 15 minutes .

By carFor participants travelling by car, there is an underground car park with 450 parking lots & 2 e-parking lots (24 hours: 36 CHF | 48 hours: 60 CHF | 72 hours: 78 CHF) .


Preliminary Program

VP2

22E

1-1/

2020

/3.0

00

Stü

Application for CME credits submitted

Organized by:


Congress DepartmentTelephone: +49-761-1514-125Telefax: +49-761-1514-359E-Mail: symposia@falk-foundation-symposia.orgwww.falk-foundation-symposia.org

Symposium 222



Organized by:


Telephone: +49-761-1514-125 Telefax: +49-761-1514-359 E-Mail: [email protected] www.falk-foundation-symposia.org

Falk

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Eosinophilic Esophagitis – Advancing Science for Everyday ... · Eosinophilic Esophagitis – Advancing Science for Everyday Challenges in Clinical Practice November 20-21, 2020