Edema and its Reduction: A Therapeutic Electromagnetic Link?clinsoft.org/drmayrovitz/PRESENTATIONS-ALL/Edema...Royal Raymond Rife Rife/Bare Plasma Tube Output 5 KHz. Harold Saxon Burr

Edema and its Reduction:

A Therapeutic

Electromagnetic Link?

September 7, 2007

Dr. Harvey N. Mayrovitz

Professor of Physiology

© 2007 Dr. HN Mayrovitz, All rights reserved

What is Edema?

What is Edema? Excess Interstitial Fluid

“Pitting” Edema

Lymphedema High Protein Content© 2007 Dr. HN Mayrovitz, All rights reserved

‘Swelling’

What are Underlying Causes of Edema?

More Fluid is Filtered than can be Removed!

Pressure – Protein – Permeability - Pumping


More Fluid is Filtered than can be Removed!

Blood Capillary

Lymphatic Capillary

+ Permeability

+ Pressure

- Protein

Interstitial

changes

Lymphatic DysfunctionBlockage

Arterioles Venules

hya

luro

na

te

co

lla

ge

n

Protein

Plasma

Fluid

-Pumping

Pressure – Protein – Permeability - Pumping


What is Electromagnetism?

How might it fit in?

Resulting in an

i(t) = induced current

Changing Magnetic

field B produced by

changing loop current

Loop

Current

iL(t)

Causes an Electric

Field E to be induced

Body Part

or Tissue

l

AJ(t) = E(t) x GTISSUEAmps/m2 Siemens/m

Electromagnetic Fields (EMF) and

Induction: Basic Considerations

E = V/l = (A/l )dB/dt

For a circular area

E = V/l = (R/2)dB/dtR ~ meters

B ~ Tesla

t ~ seconds

E ~ volts/meter


How Might Electromagnetism Fit In?

Short answer

Almost all aspects of all bodily functions

have an electrical component

Thus there are ample potential

targets for applied EMF


Induced Current

Induced E Field

Resonance Phenomena

Information Coupling

Examples of Electric Features

Macroscopic ionic currents are

present in normal tissue

Grimes et al. Phys Med Biol 1985;30:1101-1112

External Fields Might Interact with these Macroscopic Currents

Earth field ~ 0.5 Gauss = 0.5 x 10-4 Tesla

Human Skin is like a Battery

Barker et al. AJP 1982;242:R358-R366

Directly Measured Currents

Small slit

In skin

Field-Induced Currents Might Interact with these DC Currents

Human Skin Surface Voltages

Foulds and Barker Br J Dermatology 1983;109:515-522

Trans-skin voltages (n=17)

Field-Induced Voltages Might

Interact with these DC Voltages

EMF Application ModalitiesElectrodes (Contact) & Electrode-less (Non-Contact)

Low voltage Monophasic mA Pulsed Current

Low voltage Biphasic mA Pulsed Current

Microamp continuous direct current (mADC)

High voltage pulsed current (HVPC)

Contact Electro-Stimulation

+

Patent 96,044 1869

Non-Contact

Electromagnetic Induction

B

I

J(t) = E(t) x GTISSUEAmps/m2 Siemens/m

Transcranial

Magnetic

Stimulation

(TMS)

Edema Reduction Evidence?

Pennington GM et al. Military Medicine 1993;158:101-104

Edema

Diapulse

Device

Coil

Current

B-Field

Reduction

Reduction

Treatment of 50 Ankle Sprains Within 72 hours of injury

30 min – medial, 30 min – lateral 10 min – epigastric

Volumes measured before and after

Barclay V et al. Physiotherapy 1983;69:186-188

230 Hand or Thumb Injuries

Seen within 36 hours of injury

During each visit (every other day)

Received two ½ hour treatments

Diapulse Device

30 matched-pairs based on

Age – sex – degree of trauma

EdemaAmount

of

Swelling

EMF

Tx

0.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

0.64 0.50 0.42 0.41 0.35

0 1 2 3 4

Treatments* p< 0.01 vs. initial edema volume

Ed

em

a V

olu

me

(L

)*

* **

Edema Volume

• High protein content edema secondary to

node removal and/or radiation therapy

• Occurs in 20-40% of postmastectomy women

from months to years after surgery

• Usually progressive if untreated - Fibrosis

Lymphedema


Experimental Burn Injury

Deming J Burn Care Rehab 2005;26:207-227

% M

axim

um

Ed

ema

Time (Hours)

Typical Time Course

For a Burn Injury

3-Days Post Burn

Untreated

With -40mA

Full Thickness

Scald Wounds

Boiling water for 10s

Edema Inhibition in Burn Injury

Chu: J Trauma,

Volume 40(5).

May 1996.738-742

3-Days Post Burn

Chu: J Trauma, 1999;47:(2) 294-299

SN Dressing Only

SN Dressing with 40 mA DC

Protein Leak Less

Visible Evans Blue

(Bound to albumin)

Cross-Section of Underside of SNDermis

Pannicular M.

Two

Days

Post

Burn

Quantitative Protein Leak

Chu: J Trauma, 1999;47:(2) 294-299

With DC current

Without DC current

So – What’s Going On?

Short Answer – Not Sure!!


Some Things to Ponder

Georges Lakhovsky ~ 1924

Multiwave Oscillator (MWO)

Augment Natural Defenses or

Bring Defenses Back to Normal

Via External Reinforcement

Normal cells have

a natural (healthy)

vibrational equilibrium

frequency

Microbes/ Viruses

also have intrinsic

oscillatory

frequencies

External

ReinforcementLakhovsky’s Concept

Overwhelm

Normal Cells


Augment Natural Defenses or

Bring Defenses Back to Normal

Via External Reinforcement

Microbes/ Viruses

can be Destroyed

or Devitalized by

exposure to

appropriate

frequencies

Pathogenic Actions

on Normal Cells

Royal Raymond Rife ~ 1934

Destroy or Devitalize

the Bad Guys via

External Wide Band

EMF Excitation


Normal cells have

a natural (healthy)

vibrational equilibrium

frequency

Radio Energy Excited Gas

Plasma Tube as an Antenna

8-12 inches

Recent: 30 ft

27.125 MHz

Each of the multitude

of frequencies has an

associated impedance

and phase angle.

5 KHz

Bad

Guy


Demodulation

Resonance

Entrainment

Altered

Physiological

FunctionComplex

Modulated

Multi-frequency

Multi-Phase

Waves

Overriding General Precept


Key/Keyhole

interaction model

Jacques

Benveniste

But suppose

this were true

As your fertile minds begin processing the

vast amount of new information you will get

keep in mind this unsolved problem

Challenge

Ponder© 2007 Dr. HN Mayrovitz, All rights reserved

Just maybe you will discover the basis for a

potential causal – mechanistic link!

Postulate Pursue Pin-it-Down Party!


Some Added Stuff

How Might Electromagnetism Fit In?

Short answer

Almost all aspects of all bodily functions

have an electrical component

Interacting Voltages and Ionic Currents• Central and Peripheral Nervous Systems

• Cellular Membranes

• Surface Charges

• Streaming Potentials

Thus there are ample potential

targets for applied EMF


Induced Current

Induced E Field

Resonance Phenomena

Information Coupling

Untreated and Wet

Silver Nylon Dressing

Chu: J Trauma, 1996;40(5)738-742

Edema Inhibition in Burn Injury

DC current at levels

-4, -40 and +40 mA

(0.1 – 1.0 mA/cm2)

From patent # 4557273

Peaking of Skin Potential

Around Ovulation

26 year old subject over one month

1934

Patent

Lakhovsky’s Multiwave Oscillator (MWO)

Journal of the Franklin Institute 237(2):103-130 (1944)

“Under the universal microscope disease

organisms such as those of

tuberculosis, cancer, sarcoma,

streptococcus, typhoid, staphylococcus,

leprosy, hoof and mouth disease, and others

may be observed to succumb when exposed

to certain lethal frequencies, co-ordinated with

the particular frequencies peculiar to each

individual organism, and directed upon them

by rays covering a wide range of waves.”

Rife’s Universal Microscope

Resolution: 31,000 diameters

Magnification: 60,000 diameters

Rife Machine 1947

Phanotron

Tube

Modulation Frequency

16Hz – 200kHz

Modulation

Band

Modulation

Amplitude

Wein-bridge self-exciting oscillator

Resting carrier frequency and

pattern depends on tube and gas

Typical harmonics: 2.1,4.6,9.1 MHz

Modulated Wave

Royal Raymond Rife

Rife/Bare Plasma Tube Output

5 KHz

Harold Saxon Burr Fritz-Albert POPP

2-30 Hz

ActiPatch-BioElectronics Corporation

The clinical effectiveness of the product has been well

established. Testing performed at the Bioelectromagnetics

Research Laboratory at the State University of New York has

shown that ActiPatch

Therapy provides an adequate dosage of electromagnetic

energy for the treatment of soft tissue, and that its power at the

skin level is equivalent to that of traditional high-power

devices. The power level is six to nine orders of magnitude

higher than that which is required to show a biological effect. It

also demonstrated that the cumulative effect of continuous

delivery provides greater therapeutic benefit than sporadic

treatments. More information on the testing and clinical

effectiveness of our product can be found at the following web

site:

Histamine Dilation

in Hamster Cheek Pouch

Karnes et al., Arch Phys Med Rehab 1995;76:381-386

Trauma Related Edema – Prior work showed edema reduced

by High Voltage Pulsed Current (HVPC) – MECHANISM?

Photo

Courtesy of

Bill Jackson

Mechanisms? ----- Arteriole Vasoconstriction????

Karnes et al., Arch Phys Med Rehab 1995;76:381-386

HVPC = High Voltage Pulse Current

-HVPC produced edema

suppression in their

earlier work

“Anodal”

Stimulation

NO EXPLANATION

Other work

suggests

both + and –

HVPC

suppress

early (5 min)

edema in a

similar model

Taylor et al.

Phys Ther.

1997;77:1729-1740

+HVPC did not!

Dolan et al. J Athl Train. 2003; 38(3): 225–230.

CWI=cool water immersion 12.8oC

CHVPC=current

Individual

Treatments

All Treatments

No TreatmentTraumatic

Edema

Cool Water

vs.

HVPC

All Treatments

No Treatment

Ibuprofen

CHVPC

Both

Dolan et al. J Athl Train. 2005; 40(2): 111-115

Traumatic

Edema

Ibuprofen

vs.

HVPC

Coil

Current

B-Field

From patent # 4557273

29 year old subject over one month

Data from patent 3924609

Anterior Forearm

Laser-Doppler

Probes

102 Gauss

90 Gauss

50 ms/div

1 Hz 27.1 MHz

Electromagnetic Applications

Coil

Current

B-Field

Small Large

Earth Field ~ 0.5 Gauss

Simple “Electromagnet” High Power Therapeutic

Documents

Edema and its Reduction: A Therapeutic Electromagnetic Link?clinsoft.org/drmayrovitz/PRESENTATIONS-ALL/Edema...Royal Raymond Rife Rife/Bare Plasma Tube Output 5 KHz. Harold Saxon Burr