Dr Motlalepula G. MatsabisaDr Motlalepula G. Matsabisa

Indigenous Knowledge Systems [Health] Indigenous Knowledge Systems [Health]

Medical Research Council – South AfricaMedical Research Council – South Africa

Portfolio Committee on HealthPortfolio Committee on Health

April 11April 11thth 2004 2004

Our Mission and Vision

To promote and advance indigenous knowledge systems through research and development by making it a valued health model in the global environment and to redress health traditions, which until now have neglected health research priorities and issues.

To be a centre of excellence in traditional medicines research regionally and to be competitive globally

Objectives Objectives

Coordination and development of health research in indigenous knowledge

Institutional and community networks

Development of an enabling clinical trial environmentDevelopment of an enabling clinical trial environment

Innovations and commercialization in traditional health systems. Innovations and commercialization in traditional health systems.

Policies governing intellectual property and benefit-sharing Policies governing intellectual property and benefit-sharing

Research programmes that are appropriate & relevant Research programmes that are appropriate & relevant

Support academic researchSupport academic research

FundingFunding

CEO Interim: Prof AD Mbewu

Research Directorate

IKS Lead ProgrammeDirector Dr MG Matsabisa

IKS Knowledge Management

IKS Research and Development

IKS Utilization SBU

IKS Laboratory IKS Resource Centre IKS Production Facility & Quality Control Laboratory

DELFT: MRC’s Core IKS Facilities

Drug Discovery

Clinical Trials

Toxicity

New Research Methodologies

DatabasesNational Reference CentreHealth PromotionPolicyAdvocacyHealer Liaison

Poverty Eradication Programmes

Pilot Farms

Horticulture

Production GMP

MALARIA

HYPERTENSION

TUBERCULOSIS

IKS RESEARCH GUIDELINES

Research Policy

TRAMED III

NHKN

Database

DELFT CENTRE

Special Projects

CLIN

ICA

L TRIA

LS PLATFO

RM

IP POLICY

IK TRUST

•Medicinal Garden Project•Training Programme

POVERTY ALLIVIATION

TOXICOLOGY

CANCER

DIABETES

TRADITIONAL HEALERS

MONONGRAPHS

School outreach program

FARM

TRADITIONAL HEALTH CLAIMS

TDr Program

NATIONAL REFERENCE CENTRE for ATM

MCC - ATMC

IKS Research and Development IKS Knowledge Management IKS Utilization (SBU)

PAIN

ACCESS & BENEFIT-SHARING

Current Projects

HIV AND AIDS

MalariaMalaria

Preclinical studiesPreclinical studies

Clinical studiesClinical studies

O

O

O

O

O

OH

H

HH

H

HOH

H

H

HO

OO

O

O

O

H

H

H

H

H

H

H

H

O 2

14 5

67

8

910

1112

13

15

14

1'

2'4'

6'

8'9'

11'

12'

13'

15'

14'

C30H28O7

C30H28O6

Resistance Modulators

Cancer

Antibiotics

Malaria

HIV and AIDS

AnticancerAnticancer

MAS1 aqueous

0

20

40

60

80

100

0.025 0.25 2.5 25 250

micrograms/ml

% I

nh

ibit

ion

HT29

HeLa

MCF7

MAS2 aqueous

0

20

40

60

80

100

0.025 0.25 2.5 25 250

micrograms/ml

% In

hibi

tion HT29

HeLa

MCF7

MAS3 aqueous

0

20

40

60

80

100

0.025 0.25 2.5 25 250

micrograms/ml

% In

hibi

tion HT29

HeLa

MCF7

MAS3 methanol

0

20

40

60

80

100

0.025 0.25 2.5 25 250

micrograms/ml

% In

hibi

tion HT29

HeLa

MCF7

Antidiabetic Antidiabetic

Toxicity assay on Chang liver cells

0.2

0.4

0.6

0.8

0 50 100 150

[Extract] (ug/ml)

A540n

m

Glucose utilisation in Chang liver cells

0

20

40

60

80

100

120

140

160

180

Control Insulin Extract Metformin

% o

f co

ntr

ol

Acute

Chronic

Toxicity assay on C2C12 muscle cells

0.2

0.4

0.6

0.8

0 50 100 150

[Extract] (ug/ml)

A540n

m

Glucose utilisation in C2C12 muscle cells

0

20

40

60

80

100

120

140

160

180

Control Insulin Extract Metformin

% o

f co

ntr

ol

Acute

Chronic

HIV and AIDSHIV and AIDS

Assessment of Traditional Assessment of Traditional Claims for curesClaims for cures

Safety, Efficacy studiesSafety, Efficacy studies

Value additionValue addition

Clinical TrialsClinical Trials

EthicsEthicsEthics:Ethics: Informed consent for screeningInformed consent for screening Informed consent for HIV testingInformed consent for HIV testing Informed consent for participation in the studyInformed consent for participation in the study Information leaflet for the screeningInformation leaflet for the screening Information leaflet for participation in the studyInformation leaflet for participation in the study Counseling:Counseling:

Integrated approach: To whole familyIntegrated approach: To whole family

Pre-screening HIV counselingPre-screening HIV counseling

1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to 1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to appropriate & accredited centres for support) appropriate & accredited centres for support)

Ethical approval: Ethical approval: (scientific and ethical merits)(scientific and ethical merits)

Protocols are peer-reviewedProtocols are peer-reviewed Submitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluationSubmitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluation

ToxicologyToxicology

90-day sub chronic study on a non-human 90-day sub chronic study on a non-human primate modelprimate model

Clinical Human TrialsClinical Human Trials

Both Phase I and II/III Both Phase I and II/III Are double blind, randomized, placebo controlled Are double blind, randomized, placebo controlled

dose elevation parallel group studiesdose elevation parallel group studies

Case StudiesCase Studies

199

-79

23

-100

-50

0

50

100

150

200

% In

crease

/Decr

ease

1 2 3

n = 62

8696

86

0

20

40

60

80

100

% Inh

ibitio

n

In vitro HIV Protease Inhibition

Extract Extract A SO A SO 86% 86%Extract Extract B PTB PT 96% 96%Extract Extract C Cm & gC Cm & g 86% 86%

HIV and AIDSHIV and AIDS

TrainingTraining

School OutreachSchool Outreach

Community PartnershipCommunity Partnership

Medicinal Herb GardenMedicinal Herb Garden

MRC Delft Community Project

• Provide enabling environment for healers and scientists to interact

• Formal structure for healers to interact, develop policy and develop communication products

• Provide healers access to scientific infrastructure (Information, Library, Internet access, database, medicinal plant cultivation, drug discovery, Resource Centre)

• Provide a forum for structured health education and promotion (Herb garden)

• Develop skills in growing, processing, packaging and marketing of herbal products

School out-reach Program and TDr Training Program

[photos not included]

IKS UtilizationIKS Utilization

Strategic Business UnitStrategic Business Unit

Socio-economic DevelopmentSocio-economic Development

Poverty EliminationPoverty Elimination

ManufacturingManufacturing

Poverty EliminationPoverty Elimination

Organizational StructureOrganizational Structure

DST

MRC

Municipality

Community Commercial Partner

Land Infrastructure

Nursery Commercial farming

Markets

Skills transfer

Agriculture

Skills transfer

Health Education

Entrepreneurial skills development

Business development

Skills transfer

MethodologyMethodology

THE VALUE ADDED CHAINTHE VALUE ADDED CHAIN

Creation (Patents, Innovations) Creation (Patents, Innovations)

KnowledgeKnowledge

Point of entry Existing IndustriesPoint of entry Existing Industries ServicesServices

__________________________________________________________________________________________________

IndustriesIndustries

Point of entry Emerging Industries Point of entry Emerging Industries

AgricultureAgriculture

Theoretical modelTheoretical model

MARKETMARKET

Commercial viability(2)

Commercial viability(2)

Technical viability(3)

Technical viability(3)

Entrepreneurial viability(4)

Entrepreneurial viability(4)

INDUSTRY(5)

• Partnerships

INDUSTRY(5)

• Partnerships

INSTITITONALSUPPORT (1)•MRC•Municipalities•Private sector

INSTITITONALSUPPORT (1)•MRC•Municipalities•Private sector

Kimberley

Municipality: TsolwanaPlace: Hofmeyer/ Tarkastad

Municipality: SenquPlace: Sterkspruit

Anticipated ImpactAnticipated Impact

Job creation

Sustainable use of medicinal plants

Application of scientific research developed by the IKS Lead Programme

Capacity building for institutions (municipalities)

Training and promotion of the culture of entrepreneurship

The promotion of registered business ventures fully owned by emerging entrepreneurs

Horizontal and vertical integration of the area surrounding the projects.

IKS TechnologiesIKS Technologies

Systems – Mechanisms of Systems – Mechanisms of ActionAction

Analytical analysisAnalytical analysis

Quality ControlQuality Control

ManufacturingManufacturing

ProteomicsProteomics

GenomicsGenomics

MetabolimicsMetabolimics

Cytochrome P540Cytochrome P540 1a21a2 2a2a 2c19 2c19 2d62d6 2c82c8 2c92c9 2e12e1 3a43a4

How to Contact UsHow to Contact Us

Indigenous Knowledge Systems Indigenous Knowledge Systems [Health] Lead Programme[Health] Lead Programme

Dr MG MatsabisaDr MG Matsabisa – Director – Director

Tel. +27 21 938 0475Tel. +27 21 938 0475Fax. +27 21 938 0410Fax. +27 21 938 0410

E-mail. E-mail. Motlalepula.matsabisa@mrc.ac.zaMotlalepula.matsabisa@mrc.ac.za

Website:Website: www.mrc.ac.za www.mrc.ac.za

“Going back to our roots for innovative health solutions”