Doktorat D Draganovic

7/23/2019 Doktorat D Draganovic

1/21

T

149. (

: 73/10, 104/11, 84/12 108/13), 54.

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2/21

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, 2 6 7 .

(mild) (severe) .

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.(mild) RR

140 mmHg, 160 mmHg, RR 90

mmHg, 110 mmHg .

(PIH-)

, ,

.

.

, , ,

,

, , pH .


3/21

(severe) ,

.

160 mmHg, RR 110

mmHg, 2g/24h, 3 + .

, 500 ml/ 24h,

CNS (, , , , , , .), ,

, .

, , ,

III VIII, . HELLP ,

30% ,

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(PIH-),

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4/21

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5/21

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200 .

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1. (TBARS-) .

2. TBARS-

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6/21

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7/21

Metyl Dopa 500 mg 2-2,5 g,

. , , Nifedipin 10 mg 60 mg

. , , .

RR 4 h, ,

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140/90 mmHg 6 h, .

, ,

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, 7 GENERAL

ELECTRICES GE LOGIQ Book XP, 3,5 MHz.

200 ,

:

- , 18-35 35

.

-

- 28-31+6 , 32-33+6 , 34-

36+6 , 37 -40 (), .

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, ().

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scor 1 5 , , 0, 1-3, 4-7, Apgar scor

8-10.

:

1. (FL),

2. Manning-u. ( 0-

2 cm)

( 3-8 cm)

( 8 c)

3. Grannum-u ( I, II, III )

4. Koffinas- ( )

5. (BP) Manning-u, (

8-10 , 4-8, 0-4 ),

:


8/21

(NST) 30

Manning-u

6. :

(RI), .umbilicalis (AU)

(RI), . cerebri mediu (ACM) C/U , cerebro-umbilicalni

(AEDF) AU (REDF) AU

CTG , 30 . 199 , 1

. CTG 7 , CTG .

CTG 0 2 , 3 4

5 . CTG (COROMETRICS-170

SERIES I BISTOS-BT-350-FETAL MONITOR)

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, (TBARS),

,

.

(Tiobarbituric Acid Reactive

Substances)

, .

.

. 3000 rpm 10 ,

-20 C . TBARS-

(MDA), (Oxi

Select TBARS Analisa Kit (MDA ), 532 nm.

:

1. .

2. 100 l MDA .

3. 100 l SDS ( MDA

), . 5

.

4. 250 l TBA .

5. 95 C, 45-60 .

6. .

7. 3000 10 . .


9/21

8. : 200 l MDA

532 nm.

(TBARS), 2008, Oxi Select TBARS Analisa Kit.

, TBARS,

.

. 20 mol,

20 40 mol TBARS-

40 mol.

, ,

Esbahu

300-500mg/24 h, 0,

+, ++ +++ .

200

. 100 100

(PIH).

, .

, 2 h.

(g),

(cm). 10%

, 24 h .

. ,

,

. 8 m,

.

40 .

:

:

(g), : 300 g,

300-500 g, 500 g.

(cm), : 14 cm,

14-18 cm, 18 cm. (cm), : 2,5 cm,


10/21

2,5 cm.

,

. MS Excel .

SPSS (Originally: Statistical Package for the Socila Sciences, later modified to readStatistical Product and Service Solutions).

Kolmogorov-Smirnov- , Shapiro-Wilk- .

,

Mann-Whitney- U-. Mann-Whitney- U-

, .

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2 x 2

(5) 20 Fisher- . ,

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4.

62 , 26 . ,

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11/21

, ,

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200 , 200 .

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PIH , PIH, RR 160/110 mmHg

PIH, RR 160/110 mmHg.

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. PIH

33+6 .

.

, ( UZV) (CTG).

UZV

(FL).

PIH , , ,


12/21

,

.

(RI), (AU) (ACM). , C/U

,

. , ( RI)

, (RI) .

. PIH- (RI)

(AU). RI (ACM)

,

RI ACM, C/U . (C/U),

.

C/U . .

( AEDF) AU 8

PIH- 100 , ,

AU.

PIH, .

(REDF) AU

,

.

AU

.

UZV- Manning, Phellan AFI

, . -

, Manning-u 21 , 4 ,

o,

UZV

(PIH-). (BP) Manning-u

(BP) , ,

, UZV .

Koffinasa

(PIH-a) , .


13/21

,

. .

,

. UZV

Grannum-u, , III Grannum-u 34-

. III , 82 ,

, , , UZV

,

34- .

CTG ,

,

CTG 26 99 ,

100

CTG ,

,

(PIH).

()

.

2000 g

, (IUGR)

, .

1. 5. , Apgar scor,

Apgar scora 1. 0-7

, ) , 8-10 (

) , .

Apgar scora 1..

,

(PIH)

.

. ,

56%

21%.

PIH

(PIH) ,

, .

(RR) ,


14/21

(RR) 120

mmHg, 70 mmHg. (RR) 160 mmHg, (RR) 110 mmHg.

(RR) PIH 220 mmHg, (RR) 160mmHg.

61% PIH 39% PIH,

TBARS- .

, ,

(TBARS-), .

, (g), (cm)

(cm) .

,

PIH ,

.

, .

, (PIH-) : ,

, , ,

.

PIH- ,

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(TBARS-om).

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. .

, .

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,

,

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.


15/21

.

,

, .

,

. , ,

.

, (PIH)

. .

,

. 100 ,

PIH 3 , 100

, =0.246,

PIH

.

(PIH)

, 12%

, 11%.

: HELLP- ,

, ,

, , , ,

. PIH-

,

.

, 100

, 18 14 , 4 2

. 8, 4, HELLP- 2 2,

.

.

.

PIH-,

(PIH-)

, ,

(RR).

, PIH 17 14 , 4 PIH


16/21

2 . PIH 1 ,

.

.

5 , . ,

=0,059, .

, , .

, , 1 2%

, PIH ,

.

, ,

(PIH-),

, .

,

TBARS-

,

.

TBARS-

. PIH

TBARS- .

TBARS- 61,7 l,

25,8 l. TBARS-

21,7 l, 9,10 l.

TBARS- 13,2 l,

36,7 l.

(PIH).

,

,

TBARS- , TBARS-

.

TBARS- 20 l

99% , TBARS-

1% . TBARS-

, TBARS- 20 l 40 l

66% , TBARS-

40 l 34% PIH.

, TBARS-,

. , 100%

TBARS- .


17/21

, 100%

TBARS-, 20 l, TBARS- 1% .

.

(PIH) 41% , TBARS-

30,30 l, (PIH) 59%, TBARS- 41,12 l.

TBARS- PIH PIH. (PIH)

TBARS-. TBARS- 40 l.

TBARS-

(RR),

.

TBARS- (RR), ,

TBARS-

PIH. ,

TBARS-

, PIH. 34

PIH TBARS-

40 l, 32 PIH, 2

PIH, .

PIH TBARS-

20 l 40 l.

TBARS-.

TBARS-

.

, (PIH)

,

.

TBARS-

,

UZV

, , -CTG , ,

. TBARS-

TBARS-

.

, ,

.

:


18/21

1. (PIH) .

2. 99% TBARS-

, 1% TBARS- , ,

.

3. TBARS- (RR), PIH

PIH.

4.

,

,

.

5. ,

.umbilicalis (RVDF) ,

.

6.

34 .

.

7.

, 56%,

.

8. ,

.

, PIH 18

(RR), PIH 17 , PIH .

9. , , :

, , ,

,

.

10. TBARS- UZV

.

, UZV- , UZV-

BP UZV- (C/U) 1,

TBARS- .


19/21

TBARS-

PIH. TBARS- PIH UZV

,

.

11. UZV- (C/U) ,

, Sperman- ,

TBARS- C/U TBARS-

.

12. UZV- TBARS-

, , 8

UZV TBARS-

.

13. UZV- Grannumu-III

,

TBARS-

.

14.

,

CTG TBARS-,

.

CTG ,

TBARS- .

15.

TBARS- .

TBARS

PIH ,

.

16. TBARS-

.

TBARS-

PIH PIH .

TBARS- ,

TBARS- HELLP ,

.

17.


20/21

,

TBARS- PIH PIH

.

18. , ,

,

TBARS- PIH PIH

.

19. ,

, ,

TBARS- .

20.

,

TBARS- .

21.

TBARS- .

22.

, . PIH

300g TBARS-

.

23. TBARS,

,

(PIH).

24. TBARS- ,

,

(PIH). TBARS-

, .

25. ,

TBARS-, TBARS- ,

, (PIH-

). . ,


21/21

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Doktorat D Draganovic