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DNA nanotechnology: Geometric sorting

boards

Speaker： Zong-Han LiInstructor: Kun-Mao Chao

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David W. Grainger Nature Nanotechnology 4, 543 - 544 (2009)

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DNA Origami Surface patterning with DNA tiles DNA tiny chips Geometrical self-assembly

Outline

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A: single-stranded DNA and staple strands.

B: Design of a self-assembled DNA origami structure and geometry of the incorporated double-stranded DNAs.

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DNA Origami

Endo, M. and Sugiyama, H. 2011. Recent Progress in DNA Origami Technology. Current Protocols in Nucleic Acid Chemistry. 45:12.8.1–12.8.19.

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a:Nanoscale DNA tiles

b:DNA tiles decorated with different functional reagents are used to create a variety of functional devices from a mixed solution of tiles.

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Surface patterning with DNA tiles.

David W. GraingerNature Nanotechnology 4, 543 - 544 (2009)doi:10.1038/nnano.2009.249

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DNA tiny chips

Tiny, triangular DNA structures self-assemble on silicon.Credit: IBM

R. J. Kershner et al Nature Nanotechnology 4, 557 - 561 (2009) 

DNA Origami for Faster, Smaller Computer Chips

IBM suggests that it could take up to 10 years to test and refine the process for manufacturing.

6nm

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Geometrical self-assembly

DNA nanotechnology: Geometrical self-assemblyAndrew J. TurberfieldNature Chemistry 3, 580–581 (2011) doi:10.1038/nchem.1097

Attractive interactions between DNA origami tiles are coded in their complementary shaped edges, recapitulating the binding of complementary sequences of bases to form a DNA double helix.

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