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Excess glucose from the blood is stored in the liver
This glucose is then gradually released during the day for energy as needed
When the blood glucose level tends to fall, the liver releases more glucose
This helps to prevent low blood glucose, for example when we sleep
The liver will release glucose when the blood glucose is low
Maximum amount of normally
available from liver
When alcohol is consumed, the liver’s counterregulation ability is reduced
Reduced amount of available from liver in the presence of
alcohol
Let’s use an example
• Arnold goes to a party, and has 2 light, low-
calorie beers
• He goes home and sleeps
• While he sleeps, his body requires glucose
• His liver cannot make enough glucose,
• and he goes into a “hypo”
After the beers, the liver’s counterregulation ability has reduced
Reduced amount of available
from liver
If Arnold had consumed 4 before going to sleep, his waking blood glucose would be normal
Normal blood glucose of 5 mmol/L