Department of PharmacologyDepartment of PharmacologyOverview 2008-2009Overview 2008-2009

Heidi E. Hamm, Ph.D.Heidi E. Hamm, Ph.D.Earl W. Sutherland, Jr. Professor of Earl W. Sutherland, Jr. Professor of

PharmacologyPharmacologyChair, Department of PharmacologyChair, Department of Pharmacology

• Synaptic transmission and neuroscienceSynaptic transmission and neuroscienceRandy Blakely, Ron Emeson, Jeff Conn, Elaine Sanders-Bush, Heidi Hamm, Eugenia

Gurevich, Christine Konradi, Qi Zhang, Ana Carneiro, others

• Signal transductionSignal transduction Jeff Conn, Heidi Hamm, Alex Brown, John Exton, Lee Limbird, Seva Gurevich, Brian Wadzinski, Joey Barnett, Bih-Hwa Shieh, Elaine Sanders-Bush, Rich Breyer, others

• Biosynthesis and metabolism of metabolites of arachidonic acid Biosynthesis and metabolism of metabolites of arachidonic acid John Oates, Jack Roberts, Alan Brash, Alex Brown, Claus Schneider, Sean Davies, others

• Electrical and genetic basis of cardiovascular diseasesElectrical and genetic basis of cardiovascular diseasesDan Roden, Jeff Balser, Nancy Brown, Al George, Bjorn Knollman, others

• Drug DiscoveryDrug DiscoveryJeff Conn, Craig Lindsley, Dave Weaver, Carrie Jones, Scott Daniels, others

• Structural BiologyStructural Biology Tina Iverson, Ben Spiller, Seva Gurevich, Heidi Hamm, Jens Meiler

Departmental InterestsDepartmental Interests

Pharmacology Faculty RecruitmentPharmacology Faculty Recruitment

PHARMACOLOGY

NeuroscienceBlakelyDeFeliceEmesonGurevichShiehStanwoodKonradiCarneiroZhang

Drug Discovery

ConnLindsleyJonesDaniels

Weaver

Clinical PharmacologyRobertsBrashRodenBrown, NOatesSchneiderKnollmanDavies

Structural Biology

GurevichHammIverson Spiller

Systems Biology

ChungBrownHammForster

Receptors & Signal

TransductionHammSanders-BushConnGurevichBrown, A.BarnettWadzinski

Current search: Signal Transduction

Departmental AdministrationDepartmental AdministrationHEIDI E. HAMM, PH.D.

CHAIRPHARMACOLOGY

CONNIE STENQUISTDepartmental Administrator

E. Elaine BrownManager

Chase JeffordsEducational

Coordinator II

CHAIR’S OFFICE

CENTER FOR MOLECULAR NEUROSCIENCE

Randy Blakely, DirectorMary Michael, AO

DIVISION OF CLINICAL PHARMACOLOGYNancy Brown, Director

Amy Shelton, AO

Paige RobinsonAdministrative

Officer

Angela McDonaldAdministrative

Assistant III

GRANTS OFFICE

GRADUATE STUDIES OFFICE

Joey Barnett, Director

Karen GiegInterdisciplinary

Program Coordinator

Yvonne SmithAdministrative Assistant

IIIPurchasing

Lori IretonAdministrative Assistant I

Reception

Joey NeilAdministrative Assistant I

Students

ADMINISTRATIVEOFFICE

Sharon SumrellBusiness Manager

Gordon BorckLAN Manager

COMPUTEROFFICE

Edward ZhangComputer Tech I

Thomas ShafferLAN Manager

VANDERBILT PROGRAM IN DRUG DISCOVERYP. Jeff Conn, Director

Kristen RiggsAdministrative Officer

Donna IngramAdministrative Manager

Karin BargstenAdministrative Assistant

I

Tom EkmanProject Consultant

Don HucksProtocol Analyst

Julie EngersProject Consultant

Lauren MagnificoAdministrative Assistant

I

Silvio O. Conte Center for Neuroscience Research

Randy Blakely, Director

Anita PreiningerManager,

Research Operations

Recruitment since 2007Recruitment since 2007

• 20082008 DaviesDavies

• 20092009 CarneiroCarneiro ZhangZhang

• 20102010 JonesJones DanielsDaniels

• 2010 2010 Signal Transduction SearchSignal Transduction Search

Our New Faculty RecruitsOur New Faculty Recruits

• Christine Konradi Christine Konradi is a new Faculty is a new Faculty Member in Pharmacology – she Member in Pharmacology – she joined us from the Psychiatry joined us from the Psychiatry DepartmentDepartment

• She trained in the Univ. of Vienna, She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Medicine and Dentistry of New Jersey, and the Mass General Jersey, and the Mass General Hospital, Harvard Med. School.Hospital, Harvard Med. School.

• Christine works on the role of psychostimulants in gene regulation in psychiatric disorders

• She has funding from NIMH, NINDS and NIDAfunding from NIMH, NINDS and NIDA

Our New Our New FacultyFaculty Recruits Recruits

• Sean DaviesSean Davies studies the lipid studies the lipid products of oxidative stress, the products of oxidative stress, the isoketalsisoketals

• He is a joint recruit with Clinical He is a joint recruit with Clinical PharmacologyPharmacology

• He recently received the He recently received the 2007 NIH 2007 NIH Director’s New Innovator AwardDirector’s New Innovator Award to to develop better long-term treatment develop better long-term treatment strategies for chronic diseases using strategies for chronic diseases using probiotic bacteria engineered to produce probiotic bacteria engineered to produce therapeutic compounds. therapeutic compounds.

Our New Our New FacultyFaculty Recruits Recruits

• Ana CarneiroAna Carneiro studies the interactions studies the interactions of integrins with transporters with of integrins with transporters with the goal of understanding the the goal of understanding the biological function of these biological function of these interactions; her studies have interactions; her studies have important implications for important implications for depression/cardiovascular disease depression/cardiovascular disease co-morbidityco-morbidity

• She was the recipient of a NARSAD Young InvestigatorShe was the recipient of a NARSAD Young Investigator Award and Award and a NIDA research supplement to promote diversity in health-related research

Our New Our New FacultyFaculty Recruits Recruits

• Qi Zhang Qi Zhang will join Pharmacology in will join Pharmacology in May to study the regulation of “kiss-May to study the regulation of “kiss-and-run” fusion in synaptic regulationand-run” fusion in synaptic regulation

• He was recruited from Dick Tsien’s He was recruited from Dick Tsien’s laboratory in Molecular & Cellular laboratory in Molecular & Cellular Physiology at Stanford University Physiology at Stanford University

• Qi has received an NIH “Pathway to Qi has received an NIH “Pathway to Independence” K99/R00 AwardIndependence” K99/R00 Award

Our New Our New FacultyFaculty Recruits Recruits

• Scott Daniels Scott Daniels is an expert on drug is an expert on drug metabolism and pharmacokinetics metabolism and pharmacokinetics who did postdoctoral work with who did postdoctoral work with Larry Marnett at Vanderbilt and then Larry Marnett at Vanderbilt and then worked with DuPont Pharma, worked with DuPont Pharma, Millennium and Pfizer in DMPKMillennium and Pfizer in DMPK

• Scott was recently recruited to be the Head of DMPK Scott was recently recruited to be the Head of DMPK for the Vanderbilt Program in Drug Discovery and for the Vanderbilt Program in Drug Discovery and tenure-track Assistant Professor of Pharmacologytenure-track Assistant Professor of Pharmacology

Our New Our New FacultyFaculty Recruits Recruits• Carrie Jones Carrie Jones is a systems-level is a systems-level

pharmacologist who brings expertise in pharmacologist who brings expertise in in in vivo vivo behavioral neuropharmacology to the behavioral neuropharmacology to the Department. She is Head of the Department. She is Head of the In In VivoVivo/Behavior Group in the Drug Discovery /Behavior Group in the Drug Discovery teamteam

• She trained at Indiana University and Lilly and was part of the She trained at Indiana University and Lilly and was part of the preclinical and clinical team who brought fluoxitine preclinical and clinical team who brought fluoxitine (Cymbalta) to market. (Cymbalta) to market.

• She currently has an R01 through NIMH awarded in 2009She currently has an R01 through NIMH awarded in 2009

PromotionsPromotions• To Associate ProfessorTo Associate Professor

Chang Chung – promoted to Assoc. Prof. w/o tenureChang Chung – promoted to Assoc. Prof. w/o tenure

Eugenia Gurevich – in process of promotion to Assoc. Prof.Eugenia Gurevich – in process of promotion to Assoc. Prof.

•To Full ProfessorTo Full ProfessorRon EmesonRon Emeson

Seva GurevichSeva Gurevich

Joey BarnettJoey Barnett

Alex BrownAlex Brown

Craig LindsleyCraig Lindsley

How are we doing?How are we doing?

• ReputationReputation

• CitationsCitations

• NIH fundingNIH funding

• National Responsibilities & HonorsNational Responsibilities & Honors

• Local leadership rolesLocal leadership roles

Our faculty are distinguished leaders Our faculty are distinguished leaders nationally and internationallynationally and internationally

• Chair, Graduate Education Committee, ASPET: Chair, Graduate Education Committee, ASPET: Joey BarnettJoey Barnett

• ASBMB Publications Committee: ASBMB Publications Committee: Alex Brown Alex Brown

• Chair, Neuropharmacology Division, ASPET: Chair, Neuropharmacology Division, ASPET: Jeff Conn Jeff Conn

• Peer Review Advisory Committee, NIH: Peer Review Advisory Committee, NIH: Heidi HammHeidi Hamm

• Chair, Chemistry Coordination Committee, MLPCN: Chair, Chemistry Coordination Committee, MLPCN: Craig Craig LindsleyLindsley

• Editor-in-Chief, ACS Chemical Neuroscience: Craig Lindsley

• Editor-in-Chief, Molecular Pharmacology: Jeff Conn

• Associate Editor, Associate Editor, Free Radical Biology & Medicine Free Radical Biology & Medicine and Associate and Associate Editor, Editor, Prostaglandins & Other Lipid MediatorsProstaglandins & Other Lipid Mediators:: Jack Roberts

• HHMI Review Board,HHMI Review Board, Heidi HammHeidi Hamm

Our faculty are distinguished Our faculty are distinguished leaders nationally and leaders nationally and

internationallyinternationally NIMH National Advisory Mental Health Council: Jeff ConnNIMH National Advisory Mental Health Council: Jeff Conn Scientific Advisory Board, Center of Advanced European Studies

and Research: Heidi Hamm Board of Scientific Counselors, NIMH : Board of Scientific Counselors, NIMH : Randy BlakelyRandy Blakely Board of Scientific Counselors, NIDDK: Board of Scientific Counselors, NIDDK: Jeff Conn Jeff Conn NIMH Council Workgroup on Research Training, NIMH Council Workgroup on Research Training, Randy BlakelyRandy Blakely Chair, American Heart Association Greater Southeast Chair, American Heart Association Greater Southeast

Affiliate Research Committee: Affiliate Research Committee: Joey BarnettJoey Barnett

Study Section MembersStudy Section Members

• Full MembersFull MembersJoey BarnettJoey BarnettRandy BlakelyRandy BlakelyAlex BrownAlex BrownChang ChungChang ChungSeva GurevichSeva GurevichRon EmesonRon EmesonCraig LindsleyCraig LindsleyChristine Christine

KonradiKonradi

• Ad-hoc MembersAd-hoc MembersTony ForsterTony ForsterEugenia GurevichEugenia GurevichJack RobertsJack RobertsGregg StanwoodGregg Stanwood

Our faculty have received Our faculty have received national awardsnational awards

• Randy BlakelyRandy Blakely:: 20082008 Axelrod Award, ASPET Axelrod Award, ASPET 20082008 ASPET-Astellas Award in ASPET-Astellas Award in

Translational Pharmacology Translational Pharmacology

• Jeff ConnJeff Conn: : 2008 2008 PhRMA Foundation Award for PhRMA Foundation Award for Excellence in Pharmacol and ToxicolExcellence in Pharmacol and Toxicol

• Craig LindsleyCraig Lindsley:: 2010 2010 ASPET-Astellas Award in ASPET-Astellas Award in Translational Pharmacology Translational Pharmacology

• Dan Roden: 2008 Rawls Palmer Award for Progress in Medicine, Am Soc for Clin Pharm Ther

Our faculty are campus Our faculty are campus leadersleaders• Randy Blakely Randy Blakely - Director, Center for Molecular - Director, Center for Molecular

Neuroscience; Director, Conte CenterNeuroscience; Director, Conte Center

• Jeff Conn Jeff Conn - Director, Vanderbilt Program in Drug Discovery - Director, Vanderbilt Program in Drug Discovery

• Craig Lindsley Craig Lindsley – Director of Medicinal Chemistry and – Director of Medicinal Chemistry and Director of the Vanderbilt Specialized Chemistry Center for Director of the Vanderbilt Specialized Chemistry Center for Accelerated Probe DevelopmentAccelerated Probe Development

• Dan Roden Dan Roden - Director, Oates Institute of Therapeutic - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized MedicineDiscovery, Asst. Vice-Chancellor for Personalized Medicine

• Nancy Brown Nancy Brown - Chief, Clinical Pharmacology, Associate - Chief, Clinical Pharmacology, Associate Dean for Clinical and Translational Scientist DevelopmentDean for Clinical and Translational Scientist Development

Our faculty have received Our faculty have received Vanderbilt awardsVanderbilt awards

• Randy Blakely Randy Blakely received the received the F. Peter F. Peter Guengerich AwardGuengerich Award for Postdoctoral for Postdoctoral MentoringMentoring, Vanderbilt University, Vanderbilt University

• Jeff Conn Jeff Conn named the named the Lee E. Limbird Endowed Lee E. Limbird Endowed Professor of PharmacologyProfessor of Pharmacology, 2008, 2008

• Nancy BrownNancy Brown - 2008 - 2008 Elaine Sanders-Bush Elaine Sanders-Bush Faculty Award for MentoringFaculty Award for Mentoring

Extramural fundingExtramural funding

$786/sf$786/sf

Our funding has increased dramatically without an Our funding has increased dramatically without an increase in departmental budget from the SOMincrease in departmental budget from the SOM

Growth in Department of Growth in Department of PharmacologyPharmacology

Publications (Primary Faculty) Publications (Primary Faculty)

2008-2009 2008-2009 publications in publications in excellent journalsexcellent journals

• Nature Neurosci. Nature Neurosci. 11

• PNAS PNAS 66

• ScienceScience11

• PLOS MedPLOS Med 11

• StructureStructure11

• JBC JBC 1717

• Biochemistry Biochemistry 1010

• ACS Chem Biol ACS Chem Biol 1 1

• Biophys. J. Biophys. J. 7 7

• Mol Pharm Mol Pharm 2424

• JPET JPET 4 4

• J Neuroscience J Neuroscience 1414

• J Med Chem J Med Chem 1010

• J Clin InvestJ Clin Invest 2 2

Impact of Publications – Impact of Publications – PharmacologyPharmacology

1993-19971993-19971. Vanderbilt1. Vanderbilt2.2. U of WashingtonU of Washington3.3. HarvardHarvard4.4. UNCUNC5.5. Johns HopkinsJohns Hopkins6.6. UC San FranciscoUC San Francisco7.7. U of ArizonaU of Arizona8.8. U of MichiganU of Michigan9.9. U of MinnesotaU of Minnesota10.10. U of KansasU of Kansas

1997-20011997-20011. Vanderbilt1. Vanderbilt2.2. DukeDuke3.3. UC San DiegoUC San Diego4.4. U of PennsylvaniaU of Pennsylvania5.5. UC San FranciscoUC San Francisco6.6. Johns HopkinsJohns Hopkins7.7. U of ColoradoU of Colorado8.8. U of WashingtonU of Washington9.9. U of MichiganU of Michigan10.10. U of CincinnatiU of Cincinnati

ISI’s University Science Indicators

Vanderbilt ranks # 5 in The Most-Cited Institutions in Pharmacology & Toxicology, 1996-2006

This month’s New Hot PaperThis month’s New Hot Paper

# of Citations/faculty# of Citations/faculty

H Index H Index

Top CitationsTop Citations

•Randy Blakely Randy Blakely 10,14710,147

•Alan Brash Alan Brash 90399039

•Jeff Conn Jeff Conn 98719871

•Heidi Hamm Heidi Hamm 94989498

•Jack Roberts Jack Roberts 22,00222,002

Craig Lindsley: What a Craig Lindsley: What a trajectory! trajectory!

Elaine Sanders-Bush Elaine Sanders-Bush Symposium endowedSymposium endowed

Elaine has served as a leader, mentor and role model for her many trainees, her colleagues, and the larger neuroscience community.

Elaine has contributed to the success of everyone around her; scores of graduate students and postdoctoral acknowledge Elaine as critical for their success.

Her role as the Founding Director of the Vanderbilt Brain Institute made possible an academic home for the first non-departmental PhD training program, in neuroscience, at Vanderbilt, along both integrative and molecular tracks.

We celebrated her 48-year career at Vanderbilt at an Inaugural Symposium last month.

We are currently raising an Elaine Sanders-Bush Fund in her honor.

Web site redesignedWeb site redesigned

Our ChallengesOur Challenges

• Managing fast growthManaging fast growth – puts stress on faculty, – puts stress on faculty, administration, spaceadministration, space• Pharmacology is running out of spacePharmacology is running out of space• Departmental Allocation has not changed to meet needs of a Departmental Allocation has not changed to meet needs of a

larger faculty, more personnellarger faculty, more personnel

• Funding in a flat NIH environmentFunding in a flat NIH environment – faculty need to be – faculty need to be ever more adventuresome about finding funding; bridge ever more adventuresome about finding funding; bridge funding is SO appreciated!funding is SO appreciated!

• Economic crisisEconomic crisis affects us all, individually, the affects us all, individually, the department, the institution.department, the institution.

Strategic PlanningStrategic Planning

Departmental Strategic Planning Session in Dec 2008Departmental Strategic Planning Session in Dec 2008 Training Training student morale: student morale:

Students took over organization of the Annual Retreat, Journal Club Students took over organization of the Annual Retreat, Journal Club Partnership with clinicians: clinical certificate programPartnership with clinicians: clinical certificate program

ScienceScience loss of DMPK, signaling loss of DMPK, signaling drove recruitment of faculty in these areasdrove recruitment of faculty in these areas

AdministrationAdministration too much bureaucracy too much bureaucracy Fully implemented electronic financial records, ordering, Fully implemented electronic financial records, ordering,

compliance, effort reporting, animal care approvalcompliance, effort reporting, animal care approval HR two new tracks: Staff Scientist, Senior Staff ScientistHR two new tracks: Staff Scientist, Senior Staff Scientist

Graduate ProgramGraduate ProgramStrategic Planning Strategic Planning

RetreatRetreat Dec. 2009: First ever Strategic Planning Session for Pharmacology Curriculum; both faculty and students participated

Imagine what kind of training a scientist would need to be prepared for science in 2020

One theme: translational approaches from molecule to in vivo

Curriculum redesign

Planning opportunities for moving up some of our pharmacology coursework to the second semester of the first year